S100G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein may increase Ca2+ absorption by buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in duodenal basolateral membrane vesicles. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)7.08694494
2urate metabolic process (GO:0046415)6.65328335
3phosphate ion transport (GO:0006817)6.56118629
4vitamin transmembrane transport (GO:0035461)6.44688985
5drug transport (GO:0015893)6.11964810
6phosphate ion transmembrane transport (GO:0035435)6.08734840
7surfactant homeostasis (GO:0043129)5.75092003
8aminoglycoside antibiotic metabolic process (GO:0030647)5.60336651
9artery development (GO:0060840)5.16004354
10lysine catabolic process (GO:0006554)5.08500216
11lysine metabolic process (GO:0006553)5.08500216
12organic cation transport (GO:0015695)4.89177634
13drug catabolic process (GO:0042737)4.85392983
14excretion (GO:0007588)4.72403260
15vitamin D metabolic process (GO:0042359)4.55467602
16sulfur compound transport (GO:0072348)4.54304622
17bile acid and bile salt transport (GO:0015721)4.50689479
18chemical homeostasis within a tissue (GO:0048875)4.42075600
19homocysteine metabolic process (GO:0050667)4.41802678
20renal absorption (GO:0070293)4.36474208
21response to mercury ion (GO:0046689)4.36112444
22vitamin transport (GO:0051180)4.33268907
23pyrimidine-containing compound transmembrane transport (GO:0072531)4.32413734
24cysteine metabolic process (GO:0006534)4.19825075
25peptidyl-tyrosine autophosphorylation (GO:0038083)4.17933804
26nonribosomal peptide biosynthetic process (GO:0019184)4.16612241
27quaternary ammonium group transport (GO:0015697)4.15006629
28sulfate transmembrane transport (GO:1902358)4.09416182
29actin filament depolymerization (GO:0030042)4.02411406
30intestinal absorption (GO:0050892)3.97059423
31modified amino acid transport (GO:0072337)3.92385218
32glyoxylate metabolic process (GO:0046487)3.92156551
33glutathione biosynthetic process (GO:0006750)3.90800976
34exogenous drug catabolic process (GO:0042738)3.90332426
35calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.82170276
36flavonoid metabolic process (GO:0009812)3.81758700
37oligosaccharide catabolic process (GO:0009313)3.80835904
38phosphate ion homeostasis (GO:0055062)3.78333683
39trivalent inorganic anion homeostasis (GO:0072506)3.78333683
40bundle of His cell to Purkinje myocyte communication (GO:0086069)3.69056651
41cellular response to vitamin D (GO:0071305)3.60071000
42tryptophan catabolic process (GO:0006569)3.57047033
43indole-containing compound catabolic process (GO:0042436)3.57047033
44indolalkylamine catabolic process (GO:0046218)3.57047033
45short-chain fatty acid metabolic process (GO:0046459)3.55637834
46lipoprotein transport (GO:0042953)3.49731895
47regulation of histone phosphorylation (GO:0033127)3.46462059
48determination of adult lifespan (GO:0008340)3.42082272
49positive regulation of glycoprotein biosynthetic process (GO:0010560)3.37549432
50glutathione metabolic process (GO:0006749)3.36672851
51positive regulation of glycoprotein metabolic process (GO:1903020)3.36080231
52glutathione derivative metabolic process (GO:1901685)3.34956759
53glutathione derivative biosynthetic process (GO:1901687)3.34956759
54sulfate transport (GO:0008272)3.33789928
55tricarboxylic acid metabolic process (GO:0072350)3.31148526
56aromatic amino acid family catabolic process (GO:0009074)3.31008786
57carnitine transport (GO:0015879)3.28483293
58amino-acid betaine transport (GO:0015838)3.28483293
59tryptophan metabolic process (GO:0006568)3.28311976
60sulfur amino acid catabolic process (GO:0000098)3.26239011
61aspartate family amino acid catabolic process (GO:0009068)3.24867330
62metanephric tubule development (GO:0072170)3.24321045
63metanephric nephron tubule development (GO:0072234)3.24321045
64kynurenine metabolic process (GO:0070189)3.23699991
65hypotonic response (GO:0006971)3.21004742
66regulation of bile acid biosynthetic process (GO:0070857)3.16629664
67bicarbonate transport (GO:0015701)3.15318521
68peptide catabolic process (GO:0043171)3.15203643
69morphogenesis of an epithelial fold (GO:0060571)3.13234728
70fatty acid oxidation (GO:0019395)3.10719381
71fatty acid beta-oxidation (GO:0006635)3.08562321
72fructose metabolic process (GO:0006000)3.07400655
73regulation of early endosome to late endosome transport (GO:2000641)3.05030536
74transepithelial transport (GO:0070633)3.05013054
75lipid oxidation (GO:0034440)3.04068221
76regulation of cholesterol metabolic process (GO:0090181)3.03565443
77neurotransmitter biosynthetic process (GO:0042136)3.02577044
78metanephric nephron epithelium development (GO:0072243)3.01232995
79drug metabolic process (GO:0017144)2.99325368
80amino-acid betaine metabolic process (GO:0006577)2.98484578
81DNA damage induced protein phosphorylation (GO:0006975)2.97022496
82peptide biosynthetic process (GO:0043043)2.96861618
83glycoside metabolic process (GO:0016137)2.96149715
84quinone biosynthetic process (GO:1901663)2.94884937
85ubiquinone biosynthetic process (GO:0006744)2.94884937
863-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.94675292
87purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.94675292
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.90088147
89L-phenylalanine metabolic process (GO:0006558)2.90088147
90angiotensin maturation (GO:0002003)2.89263463
91cellular response to vitamin (GO:0071295)2.88108464
92response to hydroperoxide (GO:0033194)2.86624179
93toxin transport (GO:1901998)2.83621788
94carnitine metabolic process (GO:0009437)2.82361733
95neural tube formation (GO:0001841)2.82107944
96metanephric epithelium development (GO:0072207)2.81768046
97membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.81493803
98azole transport (GO:0045117)2.79643244
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.79515743
100L-phenylalanine catabolic process (GO:0006559)2.79515743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.43145523
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.83200088
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.54531503
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.22845572
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.06541780
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.03779088
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.72571154
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66629661
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.66389541
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.54290165
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.50196028
12CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.46204379
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.45676010
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.41960227
15SOX2_20726797_ChIP-Seq_SW620_Human2.34942904
16CLOCK_20551151_ChIP-Seq_293T_Human2.31115522
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23934145
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.20768010
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.06458551
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05874218
21GATA4_25053715_ChIP-Seq_YYC3_Human1.93306932
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.91853797
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.88925181
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86828303
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77223639
26NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.76852124
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76629189
28GATA6_25053715_ChIP-Seq_YYC3_Human1.76049877
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.69987239
30AR_21909140_ChIP-Seq_LNCAP_Human1.59563487
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57604380
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56287973
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.56097468
34RACK7_27058665_Chip-Seq_MCF-7_Human1.48176008
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44642600
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42993021
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37092894
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35877344
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34779251
40GATA1_22025678_ChIP-Seq_K562_Human1.34322464
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30647156
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30040703
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28647539
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25025950
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24703122
46* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22755610
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21259587
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19056128
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18488621
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14874605
51LXR_22292898_ChIP-Seq_THP-1_Human1.14596691
52CREB1_26743006_Chip-Seq_LNCaP_Human1.13502999
53BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12656918
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.12583580
55HNF4A_19822575_ChIP-Seq_HepG2_Human1.12176668
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.11617713
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09255977
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09133537
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08930944
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08778708
61GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.06945262
62MYC_19915707_ChIP-ChIP_AK7_Human1.04109550
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.03543875
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.03349875
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00744626
66EGR1_19032775_ChIP-ChIP_M12_Human1.00217745
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00074983
68GATA3_24758297_ChIP-Seq_MCF-7_Human0.98588676
69NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98385360
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98385360
71KLF5_25053715_ChIP-Seq_YYC3_Human0.97642943
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97607673
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97403801
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96935475
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96379720
76ATF3_27146783_Chip-Seq_COLON_Human0.96161788
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95706710
78FOXA2_19822575_ChIP-Seq_HepG2_Human0.94937099
79STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94498096
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93102837
81* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92919788
82TAF2_19829295_ChIP-Seq_ESCs_Human0.92595532
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90906035
84CDX2_22108803_ChIP-Seq_LS180_Human0.90596887
85RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89388435
86CTCF_27219007_Chip-Seq_Bcells_Human0.87793038
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87706299
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86574400
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86042844
90SMAD3_21741376_ChIP-Seq_HESCs_Human0.85257805
91SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84722251
92EZH2_18974828_ChIP-Seq_MESCs_Mouse0.84214271
93RNF2_18974828_ChIP-Seq_MESCs_Mouse0.84214271
94JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83882781
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.80166353
96STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.79688599
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78342844
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78325954
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77944326
100* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77677333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.72427778
2MP0003878_abnormal_ear_physiology5.54655415
3MP0005377_hearing/vestibular/ear_phenot5.54655415
4MP0002822_catalepsy4.73387440
5MP0004019_abnormal_vitamin_homeostasis4.14877947
6MP0004043_abnormal_pH_regulation3.97013691
7MP0002139_abnormal_hepatobiliary_system3.77040456
8MP0005257_abnormal_intraocular_pressure3.69860730
9MP0010234_abnormal_vibrissa_follicle3.31642636
10MP0008875_abnormal_xenobiotic_pharmacok3.31103158
11MP0005058_abnormal_lysosome_morphology3.06937070
12MP0001765_abnormal_ion_homeostasis2.80218702
13MP0009643_abnormal_urine_homeostasis2.78918638
14MP0002138_abnormal_hepatobiliary_system2.57611451
15MP0001666_abnormal_nutrient_absorption2.54189369
16MP0005085_abnormal_gallbladder_physiolo2.50537471
17MP0005167_abnormal_blood-brain_barrier2.48412251
18MP0003191_abnormal_cellular_cholesterol2.42277909
19MP0005332_abnormal_amino_acid2.35046182
20MP0005636_abnormal_mineral_homeostasis2.23676206
21MP0003283_abnormal_digestive_organ2.20586459
22MP0003252_abnormal_bile_duct2.18789089
23MP0001756_abnormal_urination2.10731393
24MP0005670_abnormal_white_adipose1.98280809
25MP0002136_abnormal_kidney_physiology1.88831584
26MP0004264_abnormal_extraembryonic_tissu1.85107414
27MP0001958_emphysema1.82611425
28MP0003195_calcinosis1.74528794
29MP0004782_abnormal_surfactant_physiolog1.62871040
30MP0003300_gastrointestinal_ulcer1.59535746
31MP0003941_abnormal_skin_development1.46285232
32MP0005365_abnormal_bile_salt1.43601451
33MP0001873_stomach_inflammation1.43195522
34MP0004885_abnormal_endolymph1.41783003
35MP0002796_impaired_skin_barrier1.41293621
36MP0000538_abnormal_urinary_bladder1.32385935
37MP0003724_increased_susceptibility_to1.32228541
38MP0000462_abnormal_digestive_system1.14459106
39MP0003315_abnormal_perineum_morphology1.14106993
40MP0010329_abnormal_lipoprotein_level1.13630738
41MP0000013_abnormal_adipose_tissue1.13154604
42MP0001663_abnormal_digestive_system1.10279086
43MP0004185_abnormal_adipocyte_glucose1.07318054
44MP0005381_digestive/alimentary_phenotyp1.06338032
45MP0003806_abnormal_nucleotide_metabolis1.05824118
46MP0001177_atelectasis1.03838753
47MP0003385_abnormal_body_wall1.00578165
48MP0001664_abnormal_digestion0.99192990
49MP0002118_abnormal_lipid_homeostasis0.98290572
50MP0005584_abnormal_enzyme/coenzyme_acti0.98121606
51MP0005084_abnormal_gallbladder_morpholo0.97075211
52MP0008961_abnormal_basal_metabolism0.96965030
53MP0003950_abnormal_plasma_membrane0.95713852
54MP0001661_extended_life_span0.95531588
55MP0005451_abnormal_body_composition0.90872858
56MP0004147_increased_porphyrin_level0.88040940
57MP0002254_reproductive_system_inflammat0.85301766
58MP0003866_abnormal_defecation0.82574723
59MP0000230_abnormal_systemic_arterial0.82354435
60MP0002098_abnormal_vibrissa_morphology0.81560526
61MP0005501_abnormal_skin_physiology0.81169774
62MP0008872_abnormal_physiological_respon0.80779088
63MP0005319_abnormal_enzyme/_coenzyme0.78832142
64MP0005666_abnormal_adipose_tissue0.78770476
65MP0004272_abnormal_basement_membrane0.73532837
66MP0000477_abnormal_intestine_morphology0.72260289
67MP0008873_increased_physiological_sensi0.66636892
68MP0006054_spinal_hemorrhage0.63191366
69MP0002135_abnormal_kidney_morphology0.62995708
70MP0003186_abnormal_redox_activity0.60860100
71MP0006036_abnormal_mitochondrial_physio0.60423632
72MP0003879_abnormal_hair_cell0.60077208
73MP0002896_abnormal_bone_mineralization0.59960721
74MP0002876_abnormal_thyroid_physiology0.59354554
75MP0008004_abnormal_stomach_pH0.59217197
76MP0003638_abnormal_response/metabolism_0.58835174
77MP0000678_abnormal_parathyroid_gland0.58051957
78MP0009780_abnormal_chondrocyte_physiolo0.56138519
79MP0009642_abnormal_blood_homeostasis0.55371116
80MP0000537_abnormal_urethra_morphology0.55046906
81MP0009384_cardiac_valve_regurgitation0.54722483
82MP0000609_abnormal_liver_physiology0.53400765
83MP0010678_abnormal_skin_adnexa0.52173673
84MP0010386_abnormal_urinary_bladder0.50968195
85MP0005165_increased_susceptibility_to0.48415047
86MP0009840_abnormal_foam_cell0.48218690
87MP0002295_abnormal_pulmonary_circulatio0.46824202
88MP0005388_respiratory_system_phenotype0.46710341
89MP0002133_abnormal_respiratory_system0.46710341
90MP0005166_decreased_susceptibility_to0.46341178
91MP0005408_hypopigmentation0.45814877
92MP0002928_abnormal_bile_duct0.45598678
93MP0005076_abnormal_cell_differentiation0.45435587
94MP0002168_other_aberrant_phenotype0.44981515
95MP0004484_altered_response_of0.43788351
96MP0000534_abnormal_ureter_morphology0.41882135
97MP0004947_skin_inflammation0.38701688
98MP0010155_abnormal_intestine_physiology0.38030510
99MP0008469_abnormal_protein_level0.36527171
100MP0006035_abnormal_mitochondrial_morpho0.35588145

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.25970447
2Metabolic alkalosis (HP:0200114)6.74366889
3Increased circulating renin level (HP:0000848)6.32718222
4Hypokalemic alkalosis (HP:0001949)6.22579634
5Abnormality of chloride homeostasis (HP:0011422)6.21165780
6Gout (HP:0001997)5.74760524
7Hypomagnesemia (HP:0002917)5.54533123
8Hyperuricemia (HP:0002149)5.39466654
9Increased purine levels (HP:0004368)5.39466654
10Malnutrition (HP:0004395)5.27601244
11Polyuria (HP:0000103)5.00502531
12Abnormality of magnesium homeostasis (HP:0004921)4.91384955
13Proximal tubulopathy (HP:0000114)4.88263017
14Abnormality of renin-angiotensin system (HP:0000847)4.80083428
15Abnormal urine output (HP:0012590)4.78946186
16Abnormality of renal excretion (HP:0011036)4.64777680
17Hyperaldosteronism (HP:0000859)4.58877017
18Abnormality of purine metabolism (HP:0004352)4.51527231
19Alkalosis (HP:0001948)4.46420680
20Renal salt wasting (HP:0000127)4.34337746
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.28714828
22Tetany (HP:0001281)4.17885554
23Generalized aminoaciduria (HP:0002909)4.10475003
24Abnormal drinking behavior (HP:0030082)3.86842597
25Polydipsia (HP:0001959)3.86842597
26Hypokalemia (HP:0002900)3.51261971
27Abnormality of urine glucose concentration (HP:0011016)3.33681451
28Glycosuria (HP:0003076)3.33681451
29Dehydration (HP:0001944)3.31959039
30Vacuolated lymphocytes (HP:0001922)3.29443062
31Prostate neoplasm (HP:0100787)3.26722339
32Hyperglycinuria (HP:0003108)3.26630102
33Oligomenorrhea (HP:0000876)3.21851224
34Hypercalciuria (HP:0002150)3.12818831
35Abnormality of nucleobase metabolism (HP:0010932)3.08624027
36Delayed epiphyseal ossification (HP:0002663)2.93198993
37Widely patent fontanelles and sutures (HP:0004492)2.89030098
38Abnormality of potassium homeostasis (HP:0011042)2.85217241
39Hydroxyprolinuria (HP:0003080)2.79714311
40Abnormality of proline metabolism (HP:0010907)2.79714311
41Abnormality of fatty-acid metabolism (HP:0004359)2.72059675
42Thin bony cortex (HP:0002753)2.66240646
43Right ventricular cardiomyopathy (HP:0011663)2.65917006
44Hyponatremia (HP:0002902)2.50948235
45Abnormality of glycine metabolism (HP:0010895)2.50476185
46Abnormality of serine family amino acid metabolism (HP:0010894)2.50476185
47Abnormality of sodium homeostasis (HP:0010931)2.45307276
48Renal tubular acidosis (HP:0001947)2.42148287
49Xanthomatosis (HP:0000991)2.41980976
50Hyperphosphaturia (HP:0003109)2.40778702
51Flat acetabular roof (HP:0003180)2.40744269
52Nephrolithiasis (HP:0000787)2.40531313
53Glomerulosclerosis (HP:0000096)2.37244513
54Hypoglycemic coma (HP:0001325)2.36648817
55Tubulointerstitial fibrosis (HP:0005576)2.36184452
56Confusion (HP:0001289)2.36176844
57Abnormality of the costochondral junction (HP:0000919)2.34474280
58Ileus (HP:0002595)2.33947648
59Metaphyseal cupping (HP:0003021)2.29038489
60Abnormality of small intestinal villus morphology (HP:0011472)2.28680576
61Villous atrophy (HP:0011473)2.28680576
62Ketoacidosis (HP:0001993)2.25975383
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25402655
64Tubular atrophy (HP:0000092)2.25175746
65Rickets (HP:0002748)2.25041198
66Abnormal urine phosphate concentration (HP:0012599)2.22510161
67Adrenal overactivity (HP:0002717)2.22111721
68Hypophosphatemia (HP:0002148)2.16505584
69Dicarboxylic aciduria (HP:0003215)2.13274328
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13274328
71Cupped ribs (HP:0000887)2.13226406
72Abnormal enzyme/coenzyme activity (HP:0012379)2.08970248
73Intrahepatic cholestasis (HP:0001406)2.07493404
74Abnormality of carpal bone ossification (HP:0006257)2.06237433
75Abnormality of alkaline phosphatase activity (HP:0004379)2.05144916
76Focal segmental glomerulosclerosis (HP:0000097)2.04542115
77Nausea (HP:0002018)2.04412996
78Pustule (HP:0200039)2.04171599
79Sensorimotor neuropathy (HP:0007141)2.01062905
80Abdominal distention (HP:0003270)1.95769656
81Autoimmune thrombocytopenia (HP:0001973)1.95293839
82Decreased circulating renin level (HP:0003351)1.89954434
83Metaphyseal irregularity (HP:0003025)1.87642615
84Abnormality of monocarboxylic acid metabolism (HP:0010996)1.86628823
85Neonatal short-limb short stature (HP:0008921)1.86594168
86Hypotension (HP:0002615)1.86337793
87Interstitial pulmonary disease (HP:0006530)1.86152836
88Vascular calcification (HP:0004934)1.84904375
89Ketosis (HP:0001946)1.84365512
90Bicornuate uterus (HP:0000813)1.82444041
91Dysostosis multiplex (HP:0000943)1.80123586
92Abnormal tarsal ossification (HP:0008369)1.79904988
93Nephrocalcinosis (HP:0000121)1.79052879
94Hyperammonemia (HP:0001987)1.79048433
95Chondrocalcinosis (HP:0000934)1.76830656
96Vomiting (HP:0002013)1.76507661
97Enlarged epiphyses (HP:0010580)1.74111725
98Visceral angiomatosis (HP:0100761)1.73711658
99Hypoalphalipoproteinemia (HP:0003233)1.72725633
100Abnormal cartilage morphology (HP:0002763)1.70298864

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA5.85966909
2WNK44.79630055
3MAP3K24.34442201
4MET3.90990083
5KSR23.80981091
6OXSR13.58107645
7WNK32.98918573
8STK392.62940347
9MAP2K22.23232274
10MST1R10.1242296
11NME11.98206022
12MST41.53673314
13MAP2K11.51336716
14LMTK21.47963083
15FRK1.40491507
16WNK11.39603710
17MAP3K11.17856952
18TBK10.96030120
19TGFBR10.87975367
20CDK90.86255510
21ACVR1B0.83924550
22EPHB10.80738796
23GRK60.79281163
24MAP3K80.78845872
25RET0.77007062
26PDK20.70245234
27EPHB20.69578100
28PRKG20.67162174
29MYLK0.63362360
30BCKDK0.61898406
31PTK20.60035085
32TIE10.59779913
33EEF2K0.59685702
34PAK40.57013036
35STK38L0.56712591
36BMPR1B0.56498321
37TESK10.54750526
38NEK10.54209326
39LRRK20.53892995
40CAMK2D0.52985960
41FGFR40.49299677
42PDK30.49009001
43PDK40.49009001
44IKBKE0.47312781
45FER0.46325968
46TGFBR20.45860745
47TAOK30.45848399
48PTK60.44863724
49KDR0.44602511
50PDPK10.41924893
51FGFR20.38929918
52SGK2230.35856603
53SGK4940.35856603
54MAP3K120.33005292
55PTK2B0.31807128
56JAK20.30858114
57MAP3K30.30466865
58IGF1R0.28358826
59STK100.25928343
60EPHA30.25873626
61DMPK0.25070195
62IRAK20.24246243
63ERN10.24135722
64MAP3K140.24108179
65IRAK10.23815436
66RIPK10.22093959
67PDK10.21506347
68MAPKAPK30.19334653
69GSK3A0.19274272
70MAPK110.18473606
71EPHA20.18370870
72NUAK10.17252223
73SCYL20.17016356
74STK380.16685989
75MELK0.13403806
76CSK0.12484330
77PAK30.12457491
78PRKCA0.11811713
79ROCK10.11696752
80SRC0.11529409
81DDR20.10939078
82DYRK1B0.10628273
83LIMK10.09984798
84PRKCI0.06652810
85PRKAA20.06559829
86ITK0.06505734
87ADRBK10.05980194
88MAP3K70.05293997
89SGK10.05230089
90MAP3K110.04117447
91ERBB20.03913486
92PIK3CG0.03907676
93MATK0.03895979
94FYN0.03750807
95NTRK10.03271964
96PRKACG0.02935180
97TRIB30.01823724
98RPS6KB20.01587200
99PRKAA10.01138900
100SGK30.00701129

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.87169294
2* Mineral absorption_Homo sapiens_hsa049783.85138854
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.00215254
4Bile secretion_Homo sapiens_hsa049762.87219069
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.77212940
6Vitamin digestion and absorption_Homo sapiens_hsa049772.60806542
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.33417405
8Butanoate metabolism_Homo sapiens_hsa006502.32811320
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25627300
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17601524
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.17424656
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12789287
13Tryptophan metabolism_Homo sapiens_hsa003802.04640403
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.03642506
15Fatty acid degradation_Homo sapiens_hsa000711.95516312
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88865240
17Propanoate metabolism_Homo sapiens_hsa006401.80171652
18Renin-angiotensin system_Homo sapiens_hsa046141.65300242
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63507649
20Histidine metabolism_Homo sapiens_hsa003401.62170276
21Glutathione metabolism_Homo sapiens_hsa004801.60054381
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59119489
23Protein digestion and absorption_Homo sapiens_hsa049741.58918819
24Pyruvate metabolism_Homo sapiens_hsa006201.56274290
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51718002
26Fat digestion and absorption_Homo sapiens_hsa049751.51156261
27Glycerolipid metabolism_Homo sapiens_hsa005611.49564721
28Other glycan degradation_Homo sapiens_hsa005111.41687055
29PPAR signaling pathway_Homo sapiens_hsa033201.41558913
30Peroxisome_Homo sapiens_hsa041461.37715360
31Folate biosynthesis_Homo sapiens_hsa007901.37472818
32Nitrogen metabolism_Homo sapiens_hsa009101.36510725
33beta-Alanine metabolism_Homo sapiens_hsa004101.36505928
34Collecting duct acid secretion_Homo sapiens_hsa049661.36134315
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29961366
36Starch and sucrose metabolism_Homo sapiens_hsa005001.26017780
37Carbon metabolism_Homo sapiens_hsa012001.24104236
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22146873
39Thyroid cancer_Homo sapiens_hsa052161.20376447
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19172971
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17965272
42Fatty acid metabolism_Homo sapiens_hsa012121.12079848
43Fructose and mannose metabolism_Homo sapiens_hsa000511.10995403
44Arginine and proline metabolism_Homo sapiens_hsa003301.03941694
45Sulfur relay system_Homo sapiens_hsa041221.02579450
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02267106
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99614962
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99015530
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.97436080
50Bladder cancer_Homo sapiens_hsa052190.95137830
51Arginine biosynthesis_Homo sapiens_hsa002200.89464888
52ABC transporters_Homo sapiens_hsa020100.89288629
53Galactose metabolism_Homo sapiens_hsa000520.87784056
54Salivary secretion_Homo sapiens_hsa049700.87303139
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86545465
56Pentose phosphate pathway_Homo sapiens_hsa000300.84647687
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84457851
58Chemical carcinogenesis_Homo sapiens_hsa052040.81635173
59Steroid biosynthesis_Homo sapiens_hsa001000.76991292
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70170087
61Thyroid hormone synthesis_Homo sapiens_hsa049180.68823685
62Tight junction_Homo sapiens_hsa045300.68556267
63Phenylalanine metabolism_Homo sapiens_hsa003600.64391567
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64094324
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63860794
66Oxidative phosphorylation_Homo sapiens_hsa001900.63451559
67Hepatitis C_Homo sapiens_hsa051600.61463255
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.57256124
69Biosynthesis of amino acids_Homo sapiens_hsa012300.56414747
70Sphingolipid metabolism_Homo sapiens_hsa006000.51044122
71Selenocompound metabolism_Homo sapiens_hsa004500.49976512
72Gastric acid secretion_Homo sapiens_hsa049710.47599797
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.45997965
74Lysosome_Homo sapiens_hsa041420.45611098
75Vibrio cholerae infection_Homo sapiens_hsa051100.39437747
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.39003526
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.37514004
78Retinol metabolism_Homo sapiens_hsa008300.37336239
79Lysine degradation_Homo sapiens_hsa003100.36802036
80Choline metabolism in cancer_Homo sapiens_hsa052310.33751804
81Metabolic pathways_Homo sapiens_hsa011000.33452117
82Pancreatic secretion_Homo sapiens_hsa049720.32290512
83Dorso-ventral axis formation_Homo sapiens_hsa043200.32232221
84Fatty acid elongation_Homo sapiens_hsa000620.31465937
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31092014
86Arachidonic acid metabolism_Homo sapiens_hsa005900.30856645
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30846385
88Caffeine metabolism_Homo sapiens_hsa002320.30838657
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30301223
90Alzheimers disease_Homo sapiens_hsa050100.29181431
91Adherens junction_Homo sapiens_hsa045200.26772614
92Parkinsons disease_Homo sapiens_hsa050120.24896950
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20716875
94Pertussis_Homo sapiens_hsa051330.19752604
95Type II diabetes mellitus_Homo sapiens_hsa049300.18881221
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.17845943
97Prion diseases_Homo sapiens_hsa050200.17349242
98Cardiac muscle contraction_Homo sapiens_hsa042600.17019019
99ECM-receptor interaction_Homo sapiens_hsa045120.15989532
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15198516

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