S100P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)6.38095088
2diterpenoid biosynthetic process (GO:0016102)5.55258090
3primary alcohol catabolic process (GO:0034310)5.07329814
4citrulline biosynthetic process (GO:0019240)4.89536067
5desmosome organization (GO:0002934)4.78853792
6cilium or flagellum-dependent cell motility (GO:0001539)4.66353181
7motile cilium assembly (GO:0044458)4.37989195
8negative regulation of humoral immune response (GO:0002921)4.19899590
9pyrimidine-containing compound transmembrane transport (GO:0072531)4.10172188
10hypotonic response (GO:0006971)3.98998482
11progesterone metabolic process (GO:0042448)3.92936969
12positive regulation of Cdc42 GTPase activity (GO:0043089)3.76587757
13vitamin transmembrane transport (GO:0035461)3.72019293
14one-carbon compound transport (GO:0019755)3.71444105
15neutrophil activation involved in immune response (GO:0002283)3.70970369
16terpenoid biosynthetic process (GO:0016114)3.70575964
17negative regulation of immunoglobulin mediated immune response (GO:0002890)3.69784881
18negative regulation of B cell mediated immunity (GO:0002713)3.69784881
19cilium movement (GO:0003341)3.61486442
20detection of other organism (GO:0098543)3.59216735
21citrulline metabolic process (GO:0000052)3.57966714
22negative regulation of glycoprotein biosynthetic process (GO:0010561)3.54669157
23multicellular organismal water homeostasis (GO:0050891)3.52969750
24detection of bacterium (GO:0016045)3.50304737
25glucose 6-phosphate metabolic process (GO:0051156)3.46093499
26response to peptidoglycan (GO:0032494)3.44679274
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43688294
28leukocyte migration involved in inflammatory response (GO:0002523)3.41150973
29flavonoid metabolic process (GO:0009812)3.39164893
30intestinal epithelial cell development (GO:0060576)3.37843185
31ethanol metabolic process (GO:0006067)3.31776502
32C21-steroid hormone metabolic process (GO:0008207)3.29091815
33tolerance induction (GO:0002507)3.18262320
34negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.15422906
35negative regulation of protein activation cascade (GO:2000258)3.15421151
36retinoic acid metabolic process (GO:0042573)3.11594589
37O-glycan processing (GO:0016266)3.06641449
38negative regulation of complement activation (GO:0045916)3.05355530
39calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.03937802
40positive regulation of tolerance induction (GO:0002645)3.03810781
41water homeostasis (GO:0030104)3.02541915
42regulation of water loss via skin (GO:0033561)3.01690090
43innate immune response in mucosa (GO:0002227)2.99264808
44neutrophil activation (GO:0042119)2.98196630
45lung epithelium development (GO:0060428)2.96218158
46response to xenobiotic stimulus (GO:0009410)2.92568158
47epithelial cilium movement (GO:0003351)2.92060458
48polyketide metabolic process (GO:0030638)2.90261365
49doxorubicin metabolic process (GO:0044598)2.90261365
50daunorubicin metabolic process (GO:0044597)2.90261365
51production of molecular mediator involved in inflammatory response (GO:0002532)2.89322018
52maintenance of gastrointestinal epithelium (GO:0030277)2.88445327
53GDP-mannose metabolic process (GO:0019673)2.88233938
54lipoxygenase pathway (GO:0019372)2.87426003
55detection of external biotic stimulus (GO:0098581)2.86972828
56negative regulation of glycoprotein metabolic process (GO:1903019)2.86706697
57positive regulation by organism of defense response of other organism involved in symbiotic interact2.85021410
58modulation by symbiont of host immune response (GO:0052553)2.85021410
59positive regulation by symbiont of host defense response (GO:0052509)2.85021410
60modulation by symbiont of host defense response (GO:0052031)2.85021410
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.85021410
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.85021410
63respiratory burst (GO:0045730)2.83428892
64positive regulation of extracellular matrix organization (GO:1903055)2.81931591
65negative regulation of lymphocyte mediated immunity (GO:0002707)2.81510928
66Golgi transport vesicle coating (GO:0048200)2.81113713
67COPI coating of Golgi vesicle (GO:0048205)2.81113713
68regulation of tolerance induction (GO:0002643)2.79614471
69antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79363309
70hepatocyte apoptotic process (GO:0097284)2.78973264
71regulation of interleukin-5 production (GO:0032674)2.75534776
72iron ion import (GO:0097286)2.74364561
73regulation of complement activation (GO:0030449)2.73947742
74establishment of skin barrier (GO:0061436)2.73010650
75bundle of His cell to Purkinje myocyte communication (GO:0086069)2.70290313
76regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.68815391
77regulation of protein activation cascade (GO:2000257)2.68378675
78regulation of viral release from host cell (GO:1902186)2.67048609
79mucosal immune response (GO:0002385)2.66726422
80positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.66389024
81ethanol oxidation (GO:0006069)2.66194276
82granulocyte activation (GO:0036230)2.63756813
83organ or tissue specific immune response (GO:0002251)2.63728338
84regulation of necrotic cell death (GO:0010939)2.63386239
85negative regulation of toll-like receptor signaling pathway (GO:0034122)2.62663459
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61613173
87aminoglycoside antibiotic metabolic process (GO:0030647)2.61504791
88retinol metabolic process (GO:0042572)2.60076702
89regulation of superoxide anion generation (GO:0032928)2.59757064
90hydrogen peroxide biosynthetic process (GO:0050665)2.59288518
91renal absorption (GO:0070293)2.56752292
92antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.55813314
93regulation of myeloid leukocyte mediated immunity (GO:0002886)2.54197717
94retinal metabolic process (GO:0042574)2.54123508
95antimicrobial humoral response (GO:0019730)2.51596144
96antigen processing and presentation of endogenous antigen (GO:0019883)2.51059931
97pentose-phosphate shunt (GO:0006098)2.50840126
98regulation of leukocyte degranulation (GO:0043300)2.50777955
99regulation of metalloenzyme activity (GO:0048552)2.50763353
100disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.49670100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.37300261
2ZNF263_19887448_ChIP-Seq_K562_Human3.11993851
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.01154440
4* ESR2_21235772_ChIP-Seq_MCF-7_Human2.94295717
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.42592942
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41828823
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.32980923
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.30614016
9* RACK7_27058665_Chip-Seq_MCF-7_Human2.29804631
10* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.20084959
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.19435015
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16075916
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14426605
14KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.08969749
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06937991
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.03311728
17* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.03243985
18CDX2_20551321_ChIP-Seq_CACO-2_Human2.02094448
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94238732
20RXR_22158963_ChIP-Seq_LIVER_Mouse1.94181913
21* SOX2_20726797_ChIP-Seq_SW620_Human1.91282658
22* LXR_22292898_ChIP-Seq_THP-1_Human1.90093407
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.89415228
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.88428242
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.87505080
26* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.83269711
27VDR_21846776_ChIP-Seq_THP-1_Human1.81729305
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75865704
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75035286
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.72202986
31ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.68176211
32GATA6_25053715_ChIP-Seq_YYC3_Human1.67361583
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66797866
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64574795
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61574565
36VDR_24763502_ChIP-Seq_THP-1_Human1.59811968
37GATA4_25053715_ChIP-Seq_YYC3_Human1.57666436
38* FOXO3_23340844_ChIP-Seq_DLD1_Human1.57315240
39ATF3_27146783_Chip-Seq_COLON_Human1.55611718
40TCF7_22412390_ChIP-Seq_EML_Mouse1.50600167
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.48190063
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48188337
43KLF5_25053715_ChIP-Seq_YYC3_Human1.44837232
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44160301
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43663156
46* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42907593
47* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42907593
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38489312
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.38093242
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.34623455
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32780813
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32472046
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31517074
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31045219
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30272897
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27897441
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.27869531
58SMC4_20622854_ChIP-Seq_HELA_Human1.27696333
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23826539
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23158915
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22739981
62CLOCK_20551151_ChIP-Seq_293T_Human1.22631801
63SPI1_23127762_ChIP-Seq_K562_Human1.21790663
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19715334
65* GATA3_24758297_ChIP-Seq_MCF-7_Human1.19649860
66GATA1_19941826_ChIP-Seq_K562_Human1.18767590
67* MAF_26560356_Chip-Seq_TH1_Human1.17431149
68* SPI1_23547873_ChIP-Seq_NB4_Human1.16533362
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16477346
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15801914
71TP63_22573176_ChIP-Seq_HFKS_Human1.15303971
72* BCOR_27268052_Chip-Seq_Bcells_Human1.14228884
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13202505
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.12805699
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12555968
76* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12346798
77* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12318131
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12280629
79* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10843013
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10386523
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.09846001
82* CREB1_26743006_Chip-Seq_LNCaP_Human1.08596947
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.07666184
84P68_20966046_ChIP-Seq_HELA_Human1.07226961
85NCOR1_26117541_ChIP-Seq_K562_Human1.05946022
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04901629
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04807792
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04609269
89BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02916267
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99528876
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98924624
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98714290
93* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98559713
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98242341
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96480864
96SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96454812
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96222109
98SA1_27219007_Chip-Seq_ERYTHROID_Human0.95078926
99KDM2B_26808549_Chip-Seq_DND41_Human0.95039596
100ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94804595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.41993505
2MP0008875_abnormal_xenobiotic_pharmacok3.42210363
3MP0004264_abnormal_extraembryonic_tissu3.00815979
4MP0008004_abnormal_stomach_pH2.80109041
5MP0005083_abnormal_biliary_tract2.72280858
6MP0003724_increased_susceptibility_to2.67301041
7MP0002132_abnormal_respiratory_system2.65117444
8MP0002796_impaired_skin_barrier2.51508253
9MP0003436_decreased_susceptibility_to2.34837693
10MP0000566_synostosis2.33515767
11MP0003191_abnormal_cellular_cholesterol2.30661596
12MP0003303_peritoneal_inflammation2.28390982
13MP0003453_abnormal_keratinocyte_physiol2.26152599
14MP0010155_abnormal_intestine_physiology2.15574869
15MP0005451_abnormal_body_composition1.98466302
16MP0000465_gastrointestinal_hemorrhage1.95106769
17MP0004947_skin_inflammation1.85359957
18MP0009785_altered_susceptibility_to1.82400677
19MP0003806_abnormal_nucleotide_metabolis1.81622238
20MP0005025_abnormal_response_to1.78708858
21MP0002419_abnormal_innate_immunity1.75831484
22MP0008260_abnormal_autophagy1.74770753
23MP0000858_altered_metastatic_potential1.73441139
24MP0004782_abnormal_surfactant_physiolog1.72992247
25MP0004019_abnormal_vitamin_homeostasis1.67436606
26MP0005501_abnormal_skin_physiology1.64743376
27MP0003656_abnormal_erythrocyte_physiolo1.63056372
28MP0005085_abnormal_gallbladder_physiolo1.62404249
29MP0003705_abnormal_hypodermis_morpholog1.62166732
30MP0005076_abnormal_cell_differentiation1.62015109
31MP0002098_abnormal_vibrissa_morphology1.59871471
32MP0005464_abnormal_platelet_physiology1.59868591
33MP0003566_abnormal_cell_adhesion1.57846823
34MP0003828_pulmonary_edema1.57299952
35MP0005365_abnormal_bile_salt1.53724787
36MP0003866_abnormal_defecation1.52454412
37MP0005058_abnormal_lysosome_morphology1.48977389
38MP0001216_abnormal_epidermal_layer1.46142446
39MP0005164_abnormal_response_to1.45727742
40MP0005165_increased_susceptibility_to1.42523639
41MP0000490_abnormal_crypts_of1.39876045
42MP0010678_abnormal_skin_adnexa1.35375230
43MP0010352_gastrointestinal_tract_polyps1.34822731
44MP0004185_abnormal_adipocyte_glucose1.34728463
45MP0001765_abnormal_ion_homeostasis1.28015016
46MP0002277_abnormal_respiratory_mucosa1.27021115
47MP0002148_abnormal_hypersensitivity_rea1.24499054
48MP0009333_abnormal_splenocyte_physiolog1.24429926
49MP0001851_eye_inflammation1.23307456
50MP0002405_respiratory_system_inflammati1.22611369
51MP0006082_CNS_inflammation1.21285704
52MP0003075_altered_response_to1.20642903
53MP0001533_abnormal_skeleton_physiology1.20033325
54MP0003183_abnormal_peptide_metabolism1.18705662
55MP0001845_abnormal_inflammatory_respons1.18668099
56MP0005023_abnormal_wound_healing1.17075249
57MP0005387_immune_system_phenotype1.15379629
58MP0001790_abnormal_immune_system1.15379629
59MP0001873_stomach_inflammation1.07474393
60MP0009643_abnormal_urine_homeostasis1.07215703
61MP0000685_abnormal_immune_system1.06709892
62MP0000467_abnormal_esophagus_morphology1.06087709
63MP0000516_abnormal_urinary_system1.05877705
64MP0005367_renal/urinary_system_phenotyp1.05877705
65MP0001664_abnormal_digestion1.05384953
66MP0004043_abnormal_pH_regulation1.05159320
67MP0002452_abnormal_antigen_presenting1.04484118
68MP0002420_abnormal_adaptive_immunity1.04191124
69MP0001819_abnormal_immune_cell1.04080897
70MP0001666_abnormal_nutrient_absorption1.03364084
71MP0004883_abnormal_blood_vessel1.03260512
72MP0002060_abnormal_skin_morphology1.03243785
73MP0005319_abnormal_enzyme/_coenzyme1.03155436
74MP0001835_abnormal_antigen_presentation1.03022385
75MP0001800_abnormal_humoral_immune1.01973376
76MP0005408_hypopigmentation1.01434377
77MP0008469_abnormal_protein_level1.00472061
78MP0000678_abnormal_parathyroid_gland0.98658241
79MP0002166_altered_tumor_susceptibility0.97536351
80MP0000470_abnormal_stomach_morphology0.97516466
81MP0002723_abnormal_immune_serum0.97177559
82MP0001849_ear_inflammation0.97083822
83MP0005636_abnormal_mineral_homeostasis0.96982549
84MP0005166_decreased_susceptibility_to0.96008024
85MP0005000_abnormal_immune_tolerance0.95550064
86MP0002136_abnormal_kidney_physiology0.92152851
87MP0004381_abnormal_hair_follicle0.91367305
88MP0000609_abnormal_liver_physiology0.90808056
89MP0000477_abnormal_intestine_morphology0.90549512
90MP0005409_darkened_coat_color0.90016007
91MP0001663_abnormal_digestive_system0.89085627
92MP0009780_abnormal_chondrocyte_physiolo0.87403567
93MP0003172_abnormal_lysosome_physiology0.85430260
94MP0003878_abnormal_ear_physiology0.85307092
95MP0005377_hearing/vestibular/ear_phenot0.85307092
96MP0009931_abnormal_skin_appearance0.85111866
97MP0005666_abnormal_adipose_tissue0.81411875
98MP0002139_abnormal_hepatobiliary_system0.81366657
99MP0000377_abnormal_hair_follicle0.80699406
100MP0005310_abnormal_salivary_gland0.79275636

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.04853121
2Chronic bronchitis (HP:0004469)6.24592818
3Abnormal respiratory epithelium morphology (HP:0012253)5.95300976
4Abnormal respiratory motile cilium morphology (HP:0005938)5.95300976
5Abnormal respiratory motile cilium physiology (HP:0012261)5.92922878
6Absent/shortened dynein arms (HP:0200106)5.68776339
7Dynein arm defect of respiratory motile cilia (HP:0012255)5.68776339
8Rhinitis (HP:0012384)5.65677672
9Abnormal ciliary motility (HP:0012262)5.50725246
10Nasal polyposis (HP:0100582)4.79793989
11Bronchiectasis (HP:0002110)4.63012034
12Hyperactive renin-angiotensin system (HP:0000841)4.62588586
13Eczematoid dermatitis (HP:0000976)4.31116047
14Abnormality of the nasal mucosa (HP:0000433)3.93849657
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.71279373
16Recurrent bacterial skin infections (HP:0005406)3.22489000
17Bronchitis (HP:0012387)3.19977370
18Recurrent abscess formation (HP:0002722)3.19108360
19Conjugated hyperbilirubinemia (HP:0002908)3.07422066
20Recurrent gram-negative bacterial infections (HP:0005420)2.97014573
21Flat acetabular roof (HP:0003180)2.90707105
22Hemorrhage of the eye (HP:0011885)2.87217764
23Recurrent otitis media (HP:0000403)2.87173511
24Lip pit (HP:0100267)2.83278138
25Recurrent sinusitis (HP:0011108)2.81651585
26Abnormality of macrophages (HP:0004311)2.80229897
27Right ventricular cardiomyopathy (HP:0011663)2.73053463
28Myositis (HP:0100614)2.65860243
29Renal salt wasting (HP:0000127)2.64185885
30Polygenic inheritance (HP:0010982)2.59430870
31Deep venous thrombosis (HP:0002625)2.55133200
32Male infertility (HP:0003251)2.44582830
33Chronic sinusitis (HP:0011109)2.37841679
34Orchitis (HP:0100796)2.34795659
35Vascular calcification (HP:0004934)2.34428310
36Amyloidosis (HP:0011034)2.29232566
37Infertility (HP:0000789)2.27932278
38Pili torti (HP:0003777)2.23679709
39Decreased circulating renin level (HP:0003351)2.23121933
40Urticaria (HP:0001025)2.18098373
41Hyperkalemia (HP:0002153)2.13915334
42Gingival bleeding (HP:0000225)2.12951535
43Increased IgE level (HP:0003212)2.12368696
44Elevated erythrocyte sedimentation rate (HP:0003565)2.11966128
45Atelectasis (HP:0100750)2.10579991
46Chronic otitis media (HP:0000389)2.08821889
47Malnutrition (HP:0004395)2.08244163
48Micronodular cirrhosis (HP:0001413)2.08127551
49Gingivitis (HP:0000230)2.06007336
50Hyponatremia (HP:0002902)2.05737743
51Abnormality of renin-angiotensin system (HP:0000847)1.99476122
52Hyperaldosteronism (HP:0000859)1.98929718
53Increased serum ferritin (HP:0003281)1.98393895
54Pustule (HP:0200039)1.96830077
55Abnormality of the distal phalanges of the toes (HP:0010182)1.95162921
56Purpura (HP:0000979)1.94035715
57Abnormality of carpal bone ossification (HP:0006257)1.93489064
58Obstructive lung disease (HP:0006536)1.93282802
59Chronic obstructive pulmonary disease (HP:0006510)1.93282802
60Cardiovascular calcification (HP:0011915)1.91558539
61Abnormal hair laboratory examination (HP:0003328)1.90516145
62Hypotension (HP:0002615)1.90509994
63Glomerulosclerosis (HP:0000096)1.90492397
64Ventricular fibrillation (HP:0001663)1.89786246
65Widely patent fontanelles and sutures (HP:0004492)1.88072566
66Abnormality of chloride homeostasis (HP:0011422)1.87420835
67Retrobulbar optic neuritis (HP:0100654)1.82529071
68Optic neuritis (HP:0100653)1.82529071
69Plantar hyperkeratosis (HP:0007556)1.82413360
70Abnormal tarsal ossification (HP:0008369)1.81305538
71Abnormality of the salivary glands (HP:0010286)1.80998944
72Focal segmental glomerulosclerosis (HP:0000097)1.80069662
73Glomerulonephritis (HP:0000099)1.80028483
74Abnormality of nail color (HP:0100643)1.77884593
75Gastrointestinal infarctions (HP:0005244)1.76469762
76Abnormality of the common coagulation pathway (HP:0010990)1.75343968
77Subacute progressive viral hepatitis (HP:0006572)1.71582391
78Hypochromic anemia (HP:0001931)1.71570756
79Congenital ichthyosiform erythroderma (HP:0007431)1.71387136
80Hypochromic microcytic anemia (HP:0004840)1.71271992
81Palmoplantar hyperkeratosis (HP:0000972)1.70099219
82Amelogenesis imperfecta (HP:0000705)1.69018499
83Seborrheic dermatitis (HP:0001051)1.67899183
84Abnormality of iron homeostasis (HP:0011031)1.67491435
85Recurrent skin infections (HP:0001581)1.65094162
86Distal lower limb muscle weakness (HP:0009053)1.63442364
87Abnormal blistering of the skin (HP:0008066)1.60012689
88Abnormality of the dental root (HP:0006486)1.59952198
89Taurodontia (HP:0000679)1.59952198
90Abnormality of permanent molar morphology (HP:0011071)1.59952198
91Abnormal vertebral ossification (HP:0100569)1.59948044
92Popliteal pterygium (HP:0009756)1.57564820
93Episodic fever (HP:0001954)1.57493471
94Cheilitis (HP:0100825)1.57226117
95Interstitial pulmonary disease (HP:0006530)1.57113604
96Onycholysis (HP:0001806)1.55944936
97Toxemia of pregnancy (HP:0100603)1.55584117
98Abnormality of the gastric mucosa (HP:0004295)1.55444247
99Alkalosis (HP:0001948)1.54723995
100Thick nail (HP:0001805)1.54322431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.91459814
2MST1R5.59761258
3ERN13.14447213
4RIPK42.52165597
5TRIB32.52119616
6MAPK152.49162609
7MST42.34585864
8SMG12.21698042
9MAP3K32.15602791
10MAP3K122.03372082
11MET1.96298302
12MAP3K21.75116830
13STK241.72232954
14IRAK41.71056305
15MAP2K31.68264338
16CSK1.65639614
17EPHB11.63324967
18IRAK31.61570556
19GRK61.58292064
20SIK11.57413388
21PAK41.57115877
22TAOK11.45248672
23PTK61.40438052
24LMTK21.37506753
25RIPK11.35090173
26ZAP701.34253005
27PRPF4B1.21867716
28TBK11.18112562
29MATK1.14750816
30LRRK21.14444156
31BLK1.12799076
32RPS6KB21.10320901
33PKN21.09173429
34TYK21.03923568
35ICK1.02945565
36NME21.02504327
37FGR1.01955239
38YES10.95445082
39NME10.93987409
40MARK20.93839172
41PDPK10.93540191
42CDK120.91645662
43MAP3K130.91580850
44MAPKAPK30.90876576
45SIK30.90525986
46FGFR30.89045047
47MAP3K10.87736381
48MAP4K10.82802475
49FGFR40.82238741
50MAP3K60.79609740
51EIF2AK10.77930843
52KSR20.75828692
53IRAK10.74896634
54PRKG20.74179545
55MAP3K110.73861415
56MAP3K140.73203494
57STK390.69479425
58TNK20.67368441
59BMPR20.64925451
60MAP3K70.62605569
61MAP2K60.62336282
62NEK60.61116435
63IRAK20.60891008
64STK380.59542879
65PTK20.58978270
66DYRK1B0.57540222
67TAOK20.56205991
68BMX0.55157518
69AKT30.53537138
70FER0.52967229
71PRKCI0.52410781
72STK100.51975150
73TESK10.51910444
74PIK3CG0.50115297
75HCK0.50027936
76PDK10.48932246
77TESK20.48519028
78MAP2K20.48518209
79FES0.40999310
80ILK0.40859129
81WNK40.40379004
82JAK20.39878547
83BTK0.39620511
84PIK3CA0.39333826
85PRKCD0.39098467
86HIPK20.38198140
87MAP3K50.36335113
88ERBB20.35781906
89PRKAA20.35706454
90CDC42BPA0.34957861
91LYN0.34731563
92RET0.34249075
93PRKD20.33964554
94MAP2K10.33567130
95CDK60.33070981
96MAPKAPK20.32179052
97PDGFRB0.32105236
98EPHA30.31183897
99ARAF0.28974224
100JAK30.28892327

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.40020691
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.82979221
3Phenylalanine metabolism_Homo sapiens_hsa003602.68568448
4Chemical carcinogenesis_Homo sapiens_hsa052042.33155035
5Histidine metabolism_Homo sapiens_hsa003402.28517781
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05800492
7Steroid hormone biosynthesis_Homo sapiens_hsa001401.97354750
8Other glycan degradation_Homo sapiens_hsa005111.82514344
9Fructose and mannose metabolism_Homo sapiens_hsa000511.78765916
10Glutathione metabolism_Homo sapiens_hsa004801.74898226
11Tyrosine metabolism_Homo sapiens_hsa003501.71730594
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70478282
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.68766876
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68663226
15Starch and sucrose metabolism_Homo sapiens_hsa005001.68474475
16Arginine biosynthesis_Homo sapiens_hsa002201.65981802
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.63017371
18Galactose metabolism_Homo sapiens_hsa000521.56892174
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.56874495
20Retinol metabolism_Homo sapiens_hsa008301.56197773
21Hepatitis C_Homo sapiens_hsa051601.48260495
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44324886
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43424017
24Complement and coagulation cascades_Homo sapiens_hsa046101.42765415
25Staphylococcus aureus infection_Homo sapiens_hsa051501.40254722
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.40088962
27Osteoclast differentiation_Homo sapiens_hsa043801.32182601
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27224408
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26215814
30Arachidonic acid metabolism_Homo sapiens_hsa005901.16496796
31Leishmaniasis_Homo sapiens_hsa051401.15313576
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11764248
33Acute myeloid leukemia_Homo sapiens_hsa052211.11070128
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.07642181
35Pancreatic cancer_Homo sapiens_hsa052120.99002413
36Tuberculosis_Homo sapiens_hsa051520.95669105
37Chronic myeloid leukemia_Homo sapiens_hsa052200.95614882
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93984255
39Legionellosis_Homo sapiens_hsa051340.91624510
40Influenza A_Homo sapiens_hsa051640.91438015
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90565796
42Endocytosis_Homo sapiens_hsa041440.90429460
43Bladder cancer_Homo sapiens_hsa052190.88115623
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86804686
45Lysosome_Homo sapiens_hsa041420.85459376
46Sphingolipid metabolism_Homo sapiens_hsa006000.85333691
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84719624
48Insulin resistance_Homo sapiens_hsa049310.84277664
49Vibrio cholerae infection_Homo sapiens_hsa051100.82703824
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82649729
51Sulfur metabolism_Homo sapiens_hsa009200.82061695
52Pentose phosphate pathway_Homo sapiens_hsa000300.80561853
53Amoebiasis_Homo sapiens_hsa051460.80373039
54B cell receptor signaling pathway_Homo sapiens_hsa046620.80345754
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.79996651
56Non-small cell lung cancer_Homo sapiens_hsa052230.79783279
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77833814
58Malaria_Homo sapiens_hsa051440.77319732
59Notch signaling pathway_Homo sapiens_hsa043300.75664231
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75010997
61VEGF signaling pathway_Homo sapiens_hsa043700.74391268
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72752822
63Thyroid cancer_Homo sapiens_hsa052160.72509643
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.71406500
65Fatty acid biosynthesis_Homo sapiens_hsa000610.68957154
66TNF signaling pathway_Homo sapiens_hsa046680.67951365
67Salmonella infection_Homo sapiens_hsa051320.66724676
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66260293
69Apoptosis_Homo sapiens_hsa042100.66012764
70Renal cell carcinoma_Homo sapiens_hsa052110.65727066
71Measles_Homo sapiens_hsa051620.63018025
72Endometrial cancer_Homo sapiens_hsa052130.62881847
73PPAR signaling pathway_Homo sapiens_hsa033200.62684722
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.62609682
75beta-Alanine metabolism_Homo sapiens_hsa004100.62167886
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61902388
77Toxoplasmosis_Homo sapiens_hsa051450.61567024
78Choline metabolism in cancer_Homo sapiens_hsa052310.61259321
79Fatty acid degradation_Homo sapiens_hsa000710.61070996
80HIF-1 signaling pathway_Homo sapiens_hsa040660.60438430
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.59044026
82Shigellosis_Homo sapiens_hsa051310.58924073
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58602931
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56231276
85Inositol phosphate metabolism_Homo sapiens_hsa005620.55851532
86Adherens junction_Homo sapiens_hsa045200.55147513
87Insulin signaling pathway_Homo sapiens_hsa049100.54862931
88Tight junction_Homo sapiens_hsa045300.54113350
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54065278
90Phagosome_Homo sapiens_hsa041450.53014101
91Collecting duct acid secretion_Homo sapiens_hsa049660.51248552
92Chemokine signaling pathway_Homo sapiens_hsa040620.51116372
93African trypanosomiasis_Homo sapiens_hsa051430.50644803
94ABC transporters_Homo sapiens_hsa020100.50092218
95Ovarian steroidogenesis_Homo sapiens_hsa049130.47429689
96Vitamin digestion and absorption_Homo sapiens_hsa049770.45962091
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.45514248
98Hematopoietic cell lineage_Homo sapiens_hsa046400.44905733
99Pertussis_Homo sapiens_hsa051330.43492287
100Bile secretion_Homo sapiens_hsa049760.40922231

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