S100PBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that was originally identified by its interaction with S100 calcium-binding protein P. Expression of this protein has been reported to be associated with pancreatic ductal adenocarcinoma. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)5.82258297
2nuclear pore complex assembly (GO:0051292)5.41499348
3pre-miRNA processing (GO:0031054)5.27270337
4nuclear pore organization (GO:0006999)5.12937750
5mitotic sister chromatid cohesion (GO:0007064)4.44166740
6negative regulation of DNA-dependent DNA replication (GO:2000104)4.37897432
7reciprocal meiotic recombination (GO:0007131)4.13841892
8reciprocal DNA recombination (GO:0035825)4.13841892
9attachment of spindle microtubules to kinetochore (GO:0008608)4.06144234
10male meiosis I (GO:0007141)4.06078163
11DNA double-strand break processing (GO:0000729)4.03757362
12neural tube formation (GO:0001841)4.00806022
13chromosome organization involved in meiosis (GO:0070192)3.96275196
14pore complex assembly (GO:0046931)3.92596001
15centriole replication (GO:0007099)3.92364841
16negative regulation of histone methylation (GO:0031061)3.88927127
17somatic diversification of immune receptors via somatic mutation (GO:0002566)3.82828390
18somatic hypermutation of immunoglobulin genes (GO:0016446)3.82828390
19meiotic chromosome segregation (GO:0045132)3.79844654
20regulation of RNA export from nucleus (GO:0046831)3.74794747
21resolution of meiotic recombination intermediates (GO:0000712)3.73574187
22chromatin remodeling at centromere (GO:0031055)3.73526449
23male meiosis (GO:0007140)3.73206993
24histone H4-K12 acetylation (GO:0043983)3.60453771
25double-strand break repair via homologous recombination (GO:0000724)3.52752953
26CENP-A containing nucleosome assembly (GO:0034080)3.51978684
27recombinational repair (GO:0000725)3.50933235
28DNA methylation involved in gamete generation (GO:0043046)3.50413403
29heterochromatin organization (GO:0070828)3.47040120
30regulation of histone H3-K9 methylation (GO:0051570)3.44010640
31regulation of nuclear cell cycle DNA replication (GO:0033262)3.43894259
32negative regulation of DNA repair (GO:0045738)3.42883268
33L-fucose catabolic process (GO:0042355)3.42344910
34fucose catabolic process (GO:0019317)3.42344910
35L-fucose metabolic process (GO:0042354)3.42344910
36gene silencing by RNA (GO:0031047)3.38653920
37histone exchange (GO:0043486)3.38452323
38replication fork processing (GO:0031297)3.36217762
39cytoplasmic mRNA processing body assembly (GO:0033962)3.35508711
40histone mRNA catabolic process (GO:0071044)3.34142430
41sister chromatid segregation (GO:0000819)3.30558332
42DNA replication checkpoint (GO:0000076)3.30478732
43regulation of centriole replication (GO:0046599)3.28967162
44histone H4-K5 acetylation (GO:0043981)3.28240453
45histone H4-K8 acetylation (GO:0043982)3.28240453
46DNA synthesis involved in DNA repair (GO:0000731)3.27333437
47meiotic nuclear division (GO:0007126)3.26982487
48protein K11-linked deubiquitination (GO:0035871)3.26779066
49meiotic cell cycle process (GO:1903046)3.24784973
50protein prenylation (GO:0018342)3.24662388
51prenylation (GO:0097354)3.24662388
52histone H2A monoubiquitination (GO:0035518)3.24049741
53microtubule anchoring (GO:0034453)3.23294264
54histone H2A acetylation (GO:0043968)3.22705319
55NLS-bearing protein import into nucleus (GO:0006607)3.21209831
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.19987282
57meiosis I (GO:0007127)3.18380334
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.17884811
59histone H3-K9 methylation (GO:0051567)3.17122632
60regulation of DNA endoreduplication (GO:0032875)3.14905680
61histone H4-K16 acetylation (GO:0043984)3.13864198
62regulation of nucleobase-containing compound transport (GO:0032239)3.12447152
63regulation of mitotic spindle checkpoint (GO:1903504)3.12189802
64regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12189802
65DNA replication-dependent nucleosome organization (GO:0034723)3.11415859
66DNA replication-dependent nucleosome assembly (GO:0006335)3.11415859
67regulation of sister chromatid cohesion (GO:0007063)3.05593245
68mitotic nuclear envelope disassembly (GO:0007077)3.05004325
69negative regulation of translation, ncRNA-mediated (GO:0040033)3.04022939
70regulation of translation, ncRNA-mediated (GO:0045974)3.04022939
71negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.04022939
72dosage compensation (GO:0007549)3.03192485
73protein K6-linked ubiquitination (GO:0085020)3.02230708
74histone H3-K9 demethylation (GO:0033169)3.01731969
75membrane disassembly (GO:0030397)3.01245921
76nuclear envelope disassembly (GO:0051081)3.01245921
77paraxial mesoderm development (GO:0048339)2.99883928
78microtubule depolymerization (GO:0007019)2.99792495
79peptidyl-lysine dimethylation (GO:0018027)2.98693900
80interkinetic nuclear migration (GO:0022027)2.98343759
81positive regulation of developmental pigmentation (GO:0048087)2.90047706
82stress granule assembly (GO:0034063)2.89922063
83histone H3-K4 trimethylation (GO:0080182)2.88448605
84maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88009978
85protein localization to kinetochore (GO:0034501)2.87927244
86regulation of gene silencing by RNA (GO:0060966)2.87307003
87regulation of posttranscriptional gene silencing (GO:0060147)2.87307003
88regulation of gene silencing by miRNA (GO:0060964)2.87307003
89gene silencing (GO:0016458)2.86890950
90regulation of protein polyubiquitination (GO:1902914)2.86464934
91histone H3-K4 methylation (GO:0051568)2.85819205
92sister chromatid cohesion (GO:0007062)2.85231897
93postreplication repair (GO:0006301)2.82975015
94DNA-dependent DNA replication (GO:0006261)2.82670413
95histone H3-K9 modification (GO:0061647)2.82043535
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81646999
97glucocorticoid receptor signaling pathway (GO:0042921)2.81169332
98mitotic sister chromatid segregation (GO:0000070)2.80365847
99mitotic chromosome condensation (GO:0007076)2.79687700
100centriole assembly (GO:0098534)2.78657249
101double-strand break repair (GO:0006302)2.76125770
102mitotic recombination (GO:0006312)2.76123430
103DNA geometric change (GO:0032392)2.75024674
104DNA duplex unwinding (GO:0032508)2.74285099
105peptidyl-lysine trimethylation (GO:0018023)2.74003549
106histone lysine methylation (GO:0034968)2.73953982
107positive regulation of mitotic sister chromatid separation (GO:1901970)2.73918021
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.73918021
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.73918021
110regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.73724959
111DNA catabolic process, exonucleolytic (GO:0000738)2.73580083
112regulation of meiosis I (GO:0060631)2.72136854
113DNA strand elongation involved in DNA replication (GO:0006271)2.72006094
114centrosome organization (GO:0051297)2.71041699
115synaptonemal complex assembly (GO:0007130)2.70132707
116DNA replication-independent nucleosome organization (GO:0034724)2.70000405
117DNA replication-independent nucleosome assembly (GO:0006336)2.70000405
118epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69852816
119regulation of centrosome duplication (GO:0010824)2.69714702
120DNA recombination (GO:0006310)2.69609292
121mismatch repair (GO:0006298)2.68567309
122monoubiquitinated protein deubiquitination (GO:0035520)2.67858316
123regulation of telomere maintenance via telomerase (GO:0032210)2.66233985
124microtubule organizing center organization (GO:0031023)2.65370980
125chromatin assembly (GO:0031497)2.65361393
126mRNA stabilization (GO:0048255)2.64794622
127RNA stabilization (GO:0043489)2.64794622
128mRNA splice site selection (GO:0006376)2.63851419
129regulation of DNA damage checkpoint (GO:2000001)2.63508606
130microtubule polymerization or depolymerization (GO:0031109)2.62628889
131negative regulation of histone modification (GO:0031057)2.62592506
132regulation of centrosome cycle (GO:0046605)2.62539182
133regulation of helicase activity (GO:0051095)2.62112278
134translesion synthesis (GO:0019985)2.61997058
135histone methylation (GO:0016571)2.61408268
136histone mRNA metabolic process (GO:0008334)2.60666587
137telomere maintenance via semi-conservative replication (GO:0032201)2.59870164
138telomere maintenance via recombination (GO:0000722)2.59542571
139nucleotide-excision repair, DNA gap filling (GO:0006297)2.59255524
140histone H4 acetylation (GO:0043967)2.59091113
141regulation of spindle organization (GO:0090224)2.58272701
142spliceosomal tri-snRNP complex assembly (GO:0000244)2.57358810
143negative regulation of meiosis (GO:0045835)2.55781968
144negative regulation of chromatin modification (GO:1903309)2.55369832
145DNA strand elongation (GO:0022616)2.55230967
146negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54952318
147DNA demethylation (GO:0080111)2.54251196
148kinetochore organization (GO:0051383)2.53920542
149intra-S DNA damage checkpoint (GO:0031573)2.53319947
150somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.52659598
151somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.52659598
152isotype switching (GO:0045190)2.52659598
153histone H3-K36 demethylation (GO:0070544)2.52438338
154DNA methylation or demethylation (GO:0044728)2.52184809
155piRNA metabolic process (GO:0034587)2.52021945
156negative regulation of DNA recombination (GO:0045910)2.51851692
157regulation of mitotic spindle organization (GO:0060236)2.50464358
158mRNA transport (GO:0051028)2.50104481
159DNA unwinding involved in DNA replication (GO:0006268)2.49975005
160protein localization to chromosome, centromeric region (GO:0071459)2.46729865
161regulation of histone methylation (GO:0031060)2.46240349
162regulation of translational termination (GO:0006449)2.45790631
163negative regulation of organelle assembly (GO:1902116)2.41631901
164protein localization to chromosome (GO:0034502)2.40593914
165regulation of NFAT protein import into nucleus (GO:0051532)2.40187604
166hippo signaling (GO:0035329)2.39757891
167nucleosome disassembly (GO:0006337)2.39663830
168protein-DNA complex disassembly (GO:0032986)2.39663830
169positive regulation of chromosome segregation (GO:0051984)2.39536370
170positive regulation of SMAD protein import into nucleus (GO:0060391)2.39039816
171histone lysine demethylation (GO:0070076)2.38100496
172synaptonemal complex organization (GO:0070193)2.37892946
173establishment of mitotic spindle localization (GO:0040001)2.37558415
174chromatin silencing (GO:0006342)2.36772020
175DNA methylation (GO:0006306)2.35811446
176DNA alkylation (GO:0006305)2.35811446
177peptidyl-arginine methylation (GO:0018216)2.34653665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.53316243
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.07956191
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.93718143
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.71844730
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.55584999
6ZNF274_21170338_ChIP-Seq_K562_Hela3.39240166
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.24551252
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07754322
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.92103642
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75352240
11GBX2_23144817_ChIP-Seq_PC3_Human2.67162258
12IGF1R_20145208_ChIP-Seq_DFB_Human2.66569345
13VDR_22108803_ChIP-Seq_LS180_Human2.60346031
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43634913
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.42381478
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37711699
17MYC_22102868_ChIP-Seq_BL_Human2.37488976
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33949082
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.33884091
20EZH2_22144423_ChIP-Seq_EOC_Human2.31898826
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.31074402
22TAF15_26573619_Chip-Seq_HEK293_Human2.29935011
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.19245320
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07765661
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99545883
26P300_19829295_ChIP-Seq_ESCs_Human1.98759038
27DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.97363844
28ZFP281_27345836_Chip-Seq_ESCs_Mouse1.95119420
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.92593512
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90243194
31IRF1_19129219_ChIP-ChIP_H3396_Human1.89446753
32* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.89406341
33PKCTHETA_26484144_Chip-Seq_BREAST_Human1.89204878
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.88856657
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.87685308
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84811923
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84811923
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84811923
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82509756
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82216413
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75638318
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.75296838
43ELK1_19687146_ChIP-ChIP_HELA_Human1.73748844
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73319511
45ER_23166858_ChIP-Seq_MCF-7_Human1.72447297
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71720311
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69649812
48* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.69474087
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67627701
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66666061
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63739768
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63471963
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.62783683
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56122439
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50907519
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50185746
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49788695
58* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47036456
59MYC_18940864_ChIP-ChIP_HL60_Human1.46507230
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46151770
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45005524
62SMAD4_21799915_ChIP-Seq_A2780_Human1.44752809
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.44136996
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42218508
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41520911
66* VDR_23849224_ChIP-Seq_CD4+_Human1.39381458
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.38959454
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38919181
69BCAT_22108803_ChIP-Seq_LS180_Human1.37958952
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37793441
71* TCF7_22412390_ChIP-Seq_EML_Mouse1.35738594
72CIITA_25753668_ChIP-Seq_RAJI_Human1.35712438
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.33877765
74CBP_20019798_ChIP-Seq_JUKART_Human1.32175399
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32175399
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32079375
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30728229
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29529556
79TBX3_20139965_ChIP-Seq_ESCs_Mouse1.29143326
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28734607
81CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28700690
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28226240
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28118700
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28118700
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28029738
86* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26914285
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26715233
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26631550
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.26562613
90TP53_22573176_ChIP-Seq_HFKS_Human1.23051596
91* KDM2B_26808549_Chip-Seq_DND41_Human1.22816444
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.22581845
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22213926
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.21691876
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.21208772
96AR_25329375_ChIP-Seq_VCAP_Human1.20975168
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20860651
98MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19565786
99* FOXP3_21729870_ChIP-Seq_TREG_Human1.19407883
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19081860
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.18143816
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18000755
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17516275
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17414077
105STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17269440
106POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.17252718
107POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16869163
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16400890
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16214959
110* RUNX2_22187159_ChIP-Seq_PCA_Human1.15676010
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.15650870
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14465067
113AR_21909140_ChIP-Seq_LNCAP_Human1.13618441
114TCF4_22108803_ChIP-Seq_LS180_Human1.13129434
115TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13096856
116NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12588842
117SOX2_19829295_ChIP-Seq_ESCs_Human1.11300853
118NANOG_19829295_ChIP-Seq_ESCs_Human1.11300853
119ISL1_27105846_Chip-Seq_CPCs_Mouse1.10058865
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10019215
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09841165
122AR_21572438_ChIP-Seq_LNCaP_Human1.09128487
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.08261406
124* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07235868
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06396769
126RNF2_27304074_Chip-Seq_NSC_Mouse1.06290032
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05834989
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05828161
129NANOG_21062744_ChIP-ChIP_HESCs_Human1.05457863
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05280549
131EWS_26573619_Chip-Seq_HEK293_Human1.05182592
132SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05178317
133SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04480197
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04371448
135CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04316189
136YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04189315
137* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02536958
138KDM2B_26808549_Chip-Seq_JURKAT_Human1.01073319
139PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00840650
140NANOG_16518401_ChIP-PET_MESCs_Mouse1.00465139
141CRX_20693478_ChIP-Seq_RETINA_Mouse1.00358360
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.98300782
143SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98127312
144P53_22387025_ChIP-Seq_ESCs_Mouse0.98066453
145* STAT3_23295773_ChIP-Seq_U87_Human0.96971777
146TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96731473
147CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95959057
148E2F1_18555785_Chip-Seq_ESCs_Mouse0.95565823
149FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95256926
150FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93969401
151FOXA1_25329375_ChIP-Seq_VCAP_Human0.93969401
152HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93681768
153PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91584084
154AR_19668381_ChIP-Seq_PC3_Human0.90843837
155DROSHA_22980978_ChIP-Seq_HELA_Human0.88258329
156KDM2B_26808549_Chip-Seq_K562_Human0.87446183
157GATA1_26923725_Chip-Seq_HPCs_Mouse0.86449507
158FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86203597
159POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84443669
160STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84366537
161FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81272692
162BRD4_25478319_ChIP-Seq_HGPS_Human0.80175919
163CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80073631
164FUS_26573619_Chip-Seq_HEK293_Human0.79366608
165VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79223749
166PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78792110
167CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78240764
168SMAD_19615063_ChIP-ChIP_OVARY_Human0.77958283
169TCF4_23295773_ChIP-Seq_U87_Human0.77043179
170TP53_16413492_ChIP-PET_HCT116_Human0.76785646
171* CHD1_26751641_Chip-Seq_LNCaP_Human0.74585343
172RING1B_27294783_Chip-Seq_NPCs_Mouse0.72563818
173* KDM5A_27292631_Chip-Seq_BREAST_Human0.71217977
174EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.71026708
175SOX2_18692474_ChIP-Seq_MESCs_Mouse0.69674195
176* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.69298237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.01139362
2MP0008877_abnormal_DNA_methylation3.25696267
3MP0003123_paternal_imprinting3.21155461
4MP0003121_genomic_imprinting3.03049259
5MP0008057_abnormal_DNA_replication3.00020945
6MP0003111_abnormal_nucleus_morphology2.86553357
7MP0003787_abnormal_imprinting2.74889659
8MP0010094_abnormal_chromosome_stability2.73729405
9MP0002102_abnormal_ear_morphology2.56396277
10MP0003122_maternal_imprinting2.50208411
11MP0005076_abnormal_cell_differentiation2.42709836
12MP0003077_abnormal_cell_cycle2.12764336
13MP0010307_abnormal_tumor_latency1.93981160
14MP0006072_abnormal_retinal_apoptosis1.91251514
15MP0004859_abnormal_synaptic_plasticity1.87443675
16MP0003890_abnormal_embryonic-extraembry1.85539373
17MP0004957_abnormal_blastocyst_morpholog1.78715938
18MP0002084_abnormal_developmental_patter1.78274236
19MP0005551_abnormal_eye_electrophysiolog1.77908460
20MP0003718_maternal_effect1.77227716
21MP0004197_abnormal_fetal_growth/weight/1.76613088
22MP0010352_gastrointestinal_tract_polyps1.76426576
23MP0001293_anophthalmia1.72804753
24MP0002938_white_spotting1.72691988
25MP0003693_abnormal_embryo_hatching1.67991132
26MP0005253_abnormal_eye_physiology1.66471997
27MP0003195_calcinosis1.64919196
28MP0005380_embryogenesis_phenotype1.62909055
29MP0001672_abnormal_embryogenesis/_devel1.62909055
30MP0000372_irregular_coat_pigmentation1.61613949
31MP0002085_abnormal_embryonic_tissue1.59329016
32MP0003646_muscle_fatigue1.58686634
33MP0002086_abnormal_extraembryonic_tissu1.58243435
34MP0000350_abnormal_cell_proliferation1.56912535
35MP0005075_abnormal_melanosome_morpholog1.55053959
36MP0001849_ear_inflammation1.53727067
37MP0005623_abnormal_meninges_morphology1.49319765
38MP0001730_embryonic_growth_arrest1.49174462
39MP0009703_decreased_birth_body1.47522956
40MP0008058_abnormal_DNA_repair1.46959131
41MP0003984_embryonic_growth_retardation1.46158949
42MP0002088_abnormal_embryonic_growth/wei1.45799700
43MP0004808_abnormal_hematopoietic_stem1.44492560
44MP0008789_abnormal_olfactory_epithelium1.40847646
45MP0010030_abnormal_orbit_morphology1.39220811
46MP0001697_abnormal_embryo_size1.38418621
47MP0001986_abnormal_taste_sensitivity1.38258408
48MP0005187_abnormal_penis_morphology1.37050419
49MP0000427_abnormal_hair_cycle1.36799251
50MP0000428_abnormal_craniofacial_morphol1.35938057
51MP0003935_abnormal_craniofacial_develop1.34936317
52MP0002210_abnormal_sex_determination1.32709705
53MP0008007_abnormal_cellular_replicative1.32207025
54MP0003283_abnormal_digestive_organ1.31759643
55MP0005248_abnormal_Harderian_gland1.31108620
56MP0003786_premature_aging1.30801508
57MP0002638_abnormal_pupillary_reflex1.30386724
58MP0003705_abnormal_hypodermis_morpholog1.28989344
59MP0008995_early_reproductive_senescence1.28951239
60MP0002653_abnormal_ependyma_morphology1.27802423
61MP0002009_preneoplasia1.26894571
62MP0004147_increased_porphyrin_level1.24834739
63MP0008961_abnormal_basal_metabolism1.23581607
64MP0004233_abnormal_muscle_weight1.23184384
65MP0010234_abnormal_vibrissa_follicle1.22873294
66MP0003861_abnormal_nervous_system1.20312401
67MP0003937_abnormal_limbs/digits/tail_de1.20268614
68MP0002822_catalepsy1.19943970
69MP0003115_abnormal_respiratory_system1.19397305
70MP0003119_abnormal_digestive_system1.19104735
71MP0005499_abnormal_olfactory_system1.18367638
72MP0005394_taste/olfaction_phenotype1.18367638
73MP0006292_abnormal_olfactory_placode1.18023789
74MP0002751_abnormal_autonomic_nervous1.17941384
75MP0009672_abnormal_birth_weight1.17884141
76MP0000534_abnormal_ureter_morphology1.17544526
77MP0004885_abnormal_endolymph1.15061879
78MP0001145_abnormal_male_reproductive1.14387189
79MP0001929_abnormal_gametogenesis1.14122951
80MP0003567_abnormal_fetal_cardiomyocyte1.13258984
81MP0000537_abnormal_urethra_morphology1.13206315
82MP0000015_abnormal_ear_pigmentation1.12138893
83MP0002080_prenatal_lethality1.11531222
84MP0001324_abnormal_eye_pigmentation1.09817227
85MP0002736_abnormal_nociception_after1.09437163
86MP0004142_abnormal_muscle_tone1.08808588
87MP0002095_abnormal_skin_pigmentation1.07526904
88MP0005645_abnormal_hypothalamus_physiol1.07001284
89MP0002396_abnormal_hematopoietic_system1.05198839
90MP0002160_abnormal_reproductive_system1.04124025
91MP0000383_abnormal_hair_follicle1.03158909
92MP0001119_abnormal_female_reproductive1.03138064
93MP0005389_reproductive_system_phenotype1.02199565
94MP0000432_abnormal_head_morphology1.02171513
95MP0006276_abnormal_autonomic_nervous1.01971766
96MP0003942_abnormal_urinary_system1.01762931
97MP0002092_abnormal_eye_morphology1.01568249
98MP0003755_abnormal_palate_morphology1.01210669
99MP0003136_yellow_coat_color1.01161283
100MP0003943_abnormal_hepatobiliary_system1.00929989
101MP0001968_abnormal_touch/_nociception1.00586414
102MP0002697_abnormal_eye_size1.00524349
103MP0000733_abnormal_muscle_development0.99559857
104MP0000653_abnormal_sex_gland0.98867751
105MP0005391_vision/eye_phenotype0.98709020
106MP0009053_abnormal_anal_canal0.98570499
107MP0003698_abnormal_male_reproductive0.98164987
108MP0002925_abnormal_cardiovascular_devel0.97756891
109MP0004133_heterotaxia0.94014055
110MP0002234_abnormal_pharynx_morphology0.93393586
111MP0009278_abnormal_bone_marrow0.93300686
112MP0002075_abnormal_coat/hair_pigmentati0.93283525
113MP0006035_abnormal_mitochondrial_morpho0.92547706
114MP0004264_abnormal_extraembryonic_tissu0.87825580
115MP0001915_intracranial_hemorrhage0.87105686
116MP0005174_abnormal_tail_pigmentation0.86974217
117MP0005646_abnormal_pituitary_gland0.86894564
118MP0009697_abnormal_copulation0.86536776
119MP0001485_abnormal_pinna_reflex0.85959074
120MP0000778_abnormal_nervous_system0.85548084
121MP0001286_abnormal_eye_development0.84758685
122MP0002928_abnormal_bile_duct0.84679355
123MP0001529_abnormal_vocalization0.84258556
124MP0003385_abnormal_body_wall0.83730567
125MP0003635_abnormal_synaptic_transmissio0.83461802
126MP0002837_dystrophic_cardiac_calcinosis0.83023240
127MP0002116_abnormal_craniofacial_bone0.82794298
128MP0000371_diluted_coat_color0.82523974
129MP0002233_abnormal_nose_morphology0.81368603
130MP0009046_muscle_twitch0.81274473
131MP0005395_other_phenotype0.81230341
132MP0003880_abnormal_central_pattern0.80782594
133MP0000516_abnormal_urinary_system0.80768128
134MP0005367_renal/urinary_system_phenotyp0.80768128
135MP0008932_abnormal_embryonic_tissue0.79845037
136MP0010678_abnormal_skin_adnexa0.79481852
137MP0005195_abnormal_posterior_eye0.79341513
138MP0000631_abnormal_neuroendocrine_gland0.78812971
139MP0000703_abnormal_thymus_morphology0.78601782
140MP0002163_abnormal_gland_morphology0.77120962
141MP0008872_abnormal_physiological_respon0.77028911
142MP0002081_perinatal_lethality0.76093853
143MP0002063_abnormal_learning/memory/cond0.75822394
144MP0008770_decreased_survivor_rate0.75619863
145MP0002152_abnormal_brain_morphology0.75324528
146MP0002249_abnormal_larynx_morphology0.75066710
147MP0003091_abnormal_cell_migration0.74948390
148MP0002932_abnormal_joint_morphology0.73768175
149MP0001984_abnormal_olfaction0.73681881
150MP0005647_abnormal_sex_gland0.72842519
151MP0002114_abnormal_axial_skeleton0.72529551
152MP0001501_abnormal_sleep_pattern0.70895271
153MP0001764_abnormal_homeostasis0.70784621
154MP0002752_abnormal_somatic_nervous0.70697878
155MP0001177_atelectasis0.69973788
156MP0002184_abnormal_innervation0.69894241
157MP0002111_abnormal_tail_morphology0.69395642
158MP0001188_hyperpigmentation0.68696803
159MP0001486_abnormal_startle_reflex0.66110114

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.41124175
2Aplasia/Hypoplasia of the uvula (HP:0010293)3.35662060
3Ependymoma (HP:0002888)3.25458405
4Volvulus (HP:0002580)3.14755278
5Abnormality of midbrain morphology (HP:0002418)3.12474451
6Molar tooth sign on MRI (HP:0002419)3.12474451
7Pancreatic fibrosis (HP:0100732)3.03663695
8Nephronophthisis (HP:0000090)2.99098246
9True hermaphroditism (HP:0010459)2.96873681
10Short 4th metacarpal (HP:0010044)2.94865179
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.94865179
12Abnormality of the ileum (HP:0001549)2.92695032
13Abnormality of the astrocytes (HP:0100707)2.91667672
14Astrocytoma (HP:0009592)2.91667672
15Clubbing of toes (HP:0100760)2.72656385
16Medulloblastoma (HP:0002885)2.69930870
17Abnormality of the renal cortex (HP:0011035)2.69772611
18Abnormality of the lower motor neuron (HP:0002366)2.62116893
19Increased nuchal translucency (HP:0010880)2.60477972
20Abnormality of the renal medulla (HP:0100957)2.58231956
21Birth length less than 3rd percentile (HP:0003561)2.57381447
22Chronic hepatic failure (HP:0100626)2.57341350
23Glioma (HP:0009733)2.56537336
24Small intestinal stenosis (HP:0012848)2.54574225
25Duodenal stenosis (HP:0100867)2.54574225
26Heterotopia (HP:0002282)2.51609651
27Sloping forehead (HP:0000340)2.50059130
28Abnormality of the fingertips (HP:0001211)2.49265547
29Hyperventilation (HP:0002883)2.47713898
30Congenital stationary night blindness (HP:0007642)2.41813438
31Abnormality of the preputium (HP:0100587)2.41791901
32Medial flaring of the eyebrow (HP:0010747)2.41335086
33Supernumerary ribs (HP:0005815)2.39944065
34Renal cortical cysts (HP:0000803)2.39475827
35Abnormality of the duodenum (HP:0002246)2.38147911
36Obsessive-compulsive behavior (HP:0000722)2.36924737
37Macroorchidism (HP:0000053)2.36346437
38Attenuation of retinal blood vessels (HP:0007843)2.36307384
39Neoplasm of the oral cavity (HP:0100649)2.35869259
40Abnormality of the labia minora (HP:0012880)2.35191623
41Renal duplication (HP:0000075)2.34302991
42Neoplasm of striated muscle (HP:0009728)2.31820414
43Duplicated collecting system (HP:0000081)2.29701614
44Abnormality of the renal collecting system (HP:0004742)2.29168060
45Vertebral arch anomaly (HP:0008438)2.27473368
46Genetic anticipation (HP:0003743)2.26574783
47Abnormal lung lobation (HP:0002101)2.25256347
48Hyperacusis (HP:0010780)2.24117607
49Progressive inability to walk (HP:0002505)2.23634623
50Long eyelashes (HP:0000527)2.21403071
51Abnormality of the 4th metacarpal (HP:0010012)2.20246476
52Pointed chin (HP:0000307)2.19811794
53Renovascular hypertension (HP:0100817)2.18608335
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.18132975
55Oligodactyly (hands) (HP:0001180)2.16942945
56Intestinal atresia (HP:0011100)2.15788363
57Gonadotropin excess (HP:0000837)2.15084383
58Methylmalonic acidemia (HP:0002912)2.14263307
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.13988458
60Trigonocephaly (HP:0000243)2.12965511
61Narrow palate (HP:0000189)2.11823406
62Abolished electroretinogram (ERG) (HP:0000550)2.11057882
63Small hand (HP:0200055)2.10461461
64Absent frontal sinuses (HP:0002688)2.10215492
65Broad thumb (HP:0011304)2.10199891
66Genital tract atresia (HP:0001827)2.10118536
67Nephrogenic diabetes insipidus (HP:0009806)2.09848389
68Astigmatism (HP:0000483)2.09293445
69Protruding tongue (HP:0010808)2.08757685
70Broad palm (HP:0001169)2.08280362
71Rhabdomyosarcoma (HP:0002859)2.08215814
72Postaxial foot polydactyly (HP:0001830)2.07488242
73Truncal obesity (HP:0001956)2.07332789
74Abnormal biliary tract physiology (HP:0012439)2.05673598
75Bile duct proliferation (HP:0001408)2.05673598
76Abnormality of DNA repair (HP:0003254)2.03964702
77Chromsome breakage (HP:0040012)2.03020383
78Elfin facies (HP:0004428)2.02643327
79Congenital primary aphakia (HP:0007707)2.02464859
80Supernumerary bones of the axial skeleton (HP:0009144)2.01587279
81Vaginal atresia (HP:0000148)2.00858579
82Basal cell carcinoma (HP:0002671)2.00631021
83Proximal placement of thumb (HP:0009623)1.98573328
84Patellar aplasia (HP:0006443)1.98522066
85Triphalangeal thumb (HP:0001199)1.97937651
86Pseudobulbar signs (HP:0002200)1.96971597
87Gait imbalance (HP:0002141)1.96598636
88Deviation of the thumb (HP:0009603)1.95916888
89Preaxial hand polydactyly (HP:0001177)1.95012106
90Ectopic kidney (HP:0000086)1.94072679
91Cystic liver disease (HP:0006706)1.93708585
92Dandy-Walker malformation (HP:0001305)1.93066376
93Lissencephaly (HP:0001339)1.91967341
94Embryonal renal neoplasm (HP:0011794)1.91632281
95Gaze-evoked nystagmus (HP:0000640)1.91280984
96Prominent nose (HP:0000448)1.91245196
97Inability to walk (HP:0002540)1.90963410
98Abnormal number of incisors (HP:0011064)1.90550364
99Facial hemangioma (HP:0000329)1.88499383
100Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88010973
101Papillary thyroid carcinoma (HP:0002895)1.87189839
102Anencephaly (HP:0002323)1.86272766
103Absent radius (HP:0003974)1.85690887
104Neoplasm of the heart (HP:0100544)1.85670045
105Sandal gap (HP:0001852)1.85659967
106Oligohydramnios (HP:0001562)1.85084616
107Colon cancer (HP:0003003)1.84663426
108Tubular atrophy (HP:0000092)1.84572633
109Enlarged penis (HP:0000040)1.83865309
110Selective tooth agenesis (HP:0001592)1.83310996
111Poor coordination (HP:0002370)1.82372680
112Myelodysplasia (HP:0002863)1.82370666
113Abnormality of chromosome segregation (HP:0002916)1.82293278
114Neoplasm of the adrenal cortex (HP:0100641)1.80523109
115Impulsivity (HP:0100710)1.80380331
116Abnormality of the diencephalon (HP:0010662)1.80329711
117Aplasia/Hypoplasia of the patella (HP:0006498)1.80310432
118Tubulointerstitial nephritis (HP:0001970)1.79506369
119Broad phalanges of the hand (HP:0009768)1.79337223
120Stomach cancer (HP:0012126)1.78005911
121Aplasia involving forearm bones (HP:0009822)1.77922781
122Absent forearm bone (HP:0003953)1.77922781
123Abnormality of the pons (HP:0007361)1.77825938
124Homocystinuria (HP:0002156)1.76840345
125Abnormality of homocysteine metabolism (HP:0010919)1.76840345
126Shallow orbits (HP:0000586)1.76622400
127Aplasia/Hypoplasia of the sternum (HP:0006714)1.75050520
128Fair hair (HP:0002286)1.74629211
129Sclerocornea (HP:0000647)1.73537722
130Gastrointestinal carcinoma (HP:0002672)1.73023780
131Malignant gastrointestinal tract tumors (HP:0006749)1.73023780
132Broad finger (HP:0001500)1.71572805
133Congenital hepatic fibrosis (HP:0002612)1.70224603
134Hypoplasia of the pons (HP:0012110)1.70107588
135Acute lymphatic leukemia (HP:0006721)1.69525959
136Abnormality of the carotid arteries (HP:0005344)1.69430347
137Skull defect (HP:0001362)1.68686376
138Missing ribs (HP:0000921)1.68495752
139Multicystic kidney dysplasia (HP:0000003)1.68451592
140Lip pit (HP:0100267)1.68231053
141Deep philtrum (HP:0002002)1.68202563
142Subacute progressive viral hepatitis (HP:0006572)1.67993171
143Bowel diverticulosis (HP:0005222)1.67458264
144Overriding aorta (HP:0002623)1.67381379
145Supernumerary spleens (HP:0009799)1.67356583
146Bilateral microphthalmos (HP:0007633)1.66354091
147Smooth philtrum (HP:0000319)1.64977048
148Urethral obstruction (HP:0000796)1.64716622
149Highly arched eyebrow (HP:0002553)1.64369689
150Anal stenosis (HP:0002025)1.63899268
151Hypoplastic iliac wings (HP:0002866)1.63388238
152Skin tags (HP:0010609)1.62866968
153Methylmalonic aciduria (HP:0012120)1.62799814
154Short foot (HP:0001773)1.62608647
155Widely spaced teeth (HP:0000687)1.62297084
156Ankyloglossia (HP:0010296)1.62151737
157Drooling (HP:0002307)1.61823441
158Bony spicule pigmentary retinopathy (HP:0007737)1.60748331
159Sacral dimple (HP:0000960)1.60468323
160Hypoplasia of the maxilla (HP:0000327)1.59671223
161Spinal muscular atrophy (HP:0007269)1.59647512
162Broad phalanx (HP:0006009)1.58928485
163Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.58155279
164Hypopigmentation of the fundus (HP:0007894)1.58150815
165Flat cornea (HP:0007720)1.58037790
166Dislocated radial head (HP:0003083)1.57568137
167Rib fusion (HP:0000902)1.56809817
168Midline defect of the nose (HP:0004122)1.55163327
169Abnormality of the radial head (HP:0003995)1.54502492
170Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.54324223
171Nephroblastoma (Wilms tumor) (HP:0002667)1.53866223
172Oligodactyly (HP:0012165)1.53147470
173Meckel diverticulum (HP:0002245)1.52494841
174Abnormality of the nasal septum (HP:0000419)1.51951920
175Attention deficit hyperactivity disorder (HP:0007018)1.51869036
176Cutis marmorata (HP:0000965)1.51709838
177Broad long bones (HP:0005622)1.51334639
178Shawl scrotum (HP:0000049)1.50631999
179Abnormality of oral frenula (HP:0000190)1.50510858
180Blepharophimosis (HP:0000581)1.50493225
181Acute myeloid leukemia (HP:0004808)1.49990802
182Abnormality of chromosome stability (HP:0003220)1.49940897
183Low anterior hairline (HP:0000294)1.49196290
184Cafe-au-lait spot (HP:0000957)1.48282381
185Cerebral aneurysm (HP:0004944)1.48230497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.57871205
2FRK4.75203062
3LATS13.16155071
4ZAK2.84439329
5CDC72.82394509
6BRD42.76076497
7BMPR1B2.61728995
8ACVR1B2.61011337
9MAP4K22.50568657
10PRKD32.40046160
11PLK42.29206101
12NEK22.16469662
13NTRK32.11968045
14TAOK31.96435539
15SIK21.87848140
16ALK1.85353643
17TAF11.84408011
18EPHA41.79390291
19MAPK131.75544485
20BUB11.75282777
21AKT31.69342539
22MAP3K101.65498844
23VRK11.64372112
24EEF2K1.57783894
25CDK61.56148404
26STK31.56059431
27ATR1.55829022
28BRSK21.52061002
29STK38L1.51860784
30INSRR1.50071184
31CAMK1G1.48528801
32CDK191.46958890
33MKNK21.43025693
34CAMK1D1.42672646
35EIF2AK31.42628612
36ADRBK21.40159270
37TTK1.39616940
38TNIK1.38750864
39CDK41.38139444
40PASK1.35093139
41PNCK1.34255070
42CHEK11.33195088
43TYRO31.32599840
44SGK31.31462072
45MTOR1.30659437
46GRK11.29484394
47PDGFRA1.28222812
48MKNK11.27491670
49CASK1.24793011
50SIK31.23877294
51ICK1.21832531
52PKN21.21280369
53OXSR11.17870965
54SGK21.16970204
55MAP3K41.16013417
56ATM1.14224444
57WEE11.14146088
58SRPK11.12715344
59SCYL21.10079119
60STK381.09719981
61PLK31.07380530
62TRIM281.06957065
63LATS21.06781968
64CDK21.06618491
65FGFR11.06322765
66CHEK21.06252957
67MAP3K91.01306745
68KSR11.00221065
69WNK10.99374920
70CDK70.95857871
71TSSK60.95188074
72PLK10.94940824
73SIK10.90944185
74CCNB10.90893957
75RIPK10.90355354
76TGFBR10.89898377
77NTRK20.89524819
78NEK10.88144714
79YES10.87840597
80CDK10.83584420
81VRK20.83451917
82MAPK100.80957206
83CDK90.79760865
84CAMKK10.78956686
85NLK0.78467466
86TLK10.75679726
87BCR0.75427503
88PDGFRB0.75203150
89CSNK1G10.74950913
90MELK0.73826109
91FGFR20.73796469
92CDC42BPA0.73759694
93CSNK1E0.73677325
94PINK10.73489248
95CSNK1D0.72881315
96MAPK140.72804675
97STK390.71707005
98FLT30.70183629
99TXK0.69861611
100PTK60.69763413
101TEC0.69297558
102CSNK1G20.68149734
103GSK3B0.67991002
104DDR20.67322127
105PRKDC0.66506748
106KIT0.66177791
107DYRK20.65910029
108NUAK10.65904340
109SGK10.65560521
110CDK30.64917570
111FGFR30.64420221
112TAOK10.64345260
113RPS6KB20.63465895
114PRKCH0.61482827
115CSNK1A1L0.58519671
116MAPK80.53770836
117MARK30.53526089
118WNK40.53517126
119EIF2AK20.52980741
120RPS6KB10.52969783
121ERBB20.52215908
122MAPKAPK50.51632142
123IRAK10.51614054
124PRKCE0.51233870
125ERBB30.50400253
126CAMKK20.50021275
127AKT10.49114369
128MAPK10.48621034
129RPS6KA30.47955517
130CSNK1G30.47826116
131AURKB0.46819655
132PLK20.46106227
133PAK60.45630245
134WNK30.45258681
135MINK10.44646527
136DYRK1A0.43889285
137MST40.42937934
138EPHA20.42515212
139BRSK10.42241207
140AKT20.42234536
141STK40.41612767
142MARK20.41256328
143MAP3K70.41225206
144STK110.41099407
145PRKCQ0.40729213
146ADRBK10.37808121
147MARK10.37637943
148CHUK0.37534689
149PBK0.37265668
150BMX0.37135479
151PTK2B0.37055950
152MAP3K130.36144671
153SYK0.35997251
154DYRK30.35243094
155MAP2K70.34445791
156CDK80.32127478
157RPS6KA50.31620479
158PRKCG0.31396346
159PAK30.31341937

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030222.84463064
2Selenocompound metabolism_Homo sapiens_hsa004502.37275179
3Phototransduction_Homo sapiens_hsa047442.05387880
4mRNA surveillance pathway_Homo sapiens_hsa030152.00242428
5RNA polymerase_Homo sapiens_hsa030201.90542512
6Propanoate metabolism_Homo sapiens_hsa006401.90407009
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84920986
8RNA transport_Homo sapiens_hsa030131.75904172
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71212712
10Cell cycle_Homo sapiens_hsa041101.66623045
11Dorso-ventral axis formation_Homo sapiens_hsa043201.66617932
12Protein export_Homo sapiens_hsa030601.65457836
13Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.65260664
14Butanoate metabolism_Homo sapiens_hsa006501.61229750
15Fanconi anemia pathway_Homo sapiens_hsa034601.60972784
16Lysine degradation_Homo sapiens_hsa003101.58389498
17mTOR signaling pathway_Homo sapiens_hsa041501.55062793
18Basal cell carcinoma_Homo sapiens_hsa052171.47544087
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47350589
20Oocyte meiosis_Homo sapiens_hsa041141.46016788
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44385826
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43565028
23Long-term potentiation_Homo sapiens_hsa047201.37380927
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37091250
25Thyroid hormone signaling pathway_Homo sapiens_hsa049191.36535065
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34684263
27Mismatch repair_Homo sapiens_hsa034301.33174744
28MicroRNAs in cancer_Homo sapiens_hsa052061.32867869
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30762973
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28018749
31Taste transduction_Homo sapiens_hsa047421.27552499
32Adherens junction_Homo sapiens_hsa045201.27154236
33Spliceosome_Homo sapiens_hsa030401.24633959
34Hippo signaling pathway_Homo sapiens_hsa043901.24067980
35Colorectal cancer_Homo sapiens_hsa052101.22596003
36Amphetamine addiction_Homo sapiens_hsa050311.20324581
37Chronic myeloid leukemia_Homo sapiens_hsa052201.20168602
38Endometrial cancer_Homo sapiens_hsa052131.16535456
39Wnt signaling pathway_Homo sapiens_hsa043101.14442901
40Purine metabolism_Homo sapiens_hsa002301.13417479
41Type II diabetes mellitus_Homo sapiens_hsa049301.12820107
42Glioma_Homo sapiens_hsa052141.12702326
43Olfactory transduction_Homo sapiens_hsa047401.12667434
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10365455
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10132394
46One carbon pool by folate_Homo sapiens_hsa006701.09895487
47Pyrimidine metabolism_Homo sapiens_hsa002401.09373226
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08450458
49Hedgehog signaling pathway_Homo sapiens_hsa043401.05937617
50Proteoglycans in cancer_Homo sapiens_hsa052051.05379504
51Nicotine addiction_Homo sapiens_hsa050331.05103366
52Non-small cell lung cancer_Homo sapiens_hsa052231.03731324
53HTLV-I infection_Homo sapiens_hsa051661.02757768
54Ether lipid metabolism_Homo sapiens_hsa005651.02291729
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02111556
56Estrogen signaling pathway_Homo sapiens_hsa049151.01261169
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99920376
58Linoleic acid metabolism_Homo sapiens_hsa005910.99620935
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.99339425
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98845996
61Morphine addiction_Homo sapiens_hsa050320.98594972
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97695462
63Notch signaling pathway_Homo sapiens_hsa043300.97519840
64Non-homologous end-joining_Homo sapiens_hsa034500.97132432
65DNA replication_Homo sapiens_hsa030300.97003662
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.96508476
67ErbB signaling pathway_Homo sapiens_hsa040120.95150080
68Circadian entrainment_Homo sapiens_hsa047130.94615950
69Prostate cancer_Homo sapiens_hsa052150.92924410
70Dopaminergic synapse_Homo sapiens_hsa047280.92056335
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90758145
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90450008
73Base excision repair_Homo sapiens_hsa034100.89820959
74Small cell lung cancer_Homo sapiens_hsa052220.89564410
75Melanogenesis_Homo sapiens_hsa049160.89468395
76Cocaine addiction_Homo sapiens_hsa050300.88778207
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87931745
78T cell receptor signaling pathway_Homo sapiens_hsa046600.87355146
79p53 signaling pathway_Homo sapiens_hsa041150.87024819
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86891934
81Regulation of autophagy_Homo sapiens_hsa041400.86702147
82Nitrogen metabolism_Homo sapiens_hsa009100.86618401
83Thyroid cancer_Homo sapiens_hsa052160.83887032
84FoxO signaling pathway_Homo sapiens_hsa040680.82685932
85Choline metabolism in cancer_Homo sapiens_hsa052310.80509516
86TGF-beta signaling pathway_Homo sapiens_hsa043500.80085691
87RNA degradation_Homo sapiens_hsa030180.80003162
88GnRH signaling pathway_Homo sapiens_hsa049120.78121842
89Viral carcinogenesis_Homo sapiens_hsa052030.78004494
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77506285
91Homologous recombination_Homo sapiens_hsa034400.77038990
92Inositol phosphate metabolism_Homo sapiens_hsa005620.76812726
93cAMP signaling pathway_Homo sapiens_hsa040240.76760072
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76401256
95Insulin secretion_Homo sapiens_hsa049110.75334067
96Pathways in cancer_Homo sapiens_hsa052000.74290865
97ABC transporters_Homo sapiens_hsa020100.74248374
98Glucagon signaling pathway_Homo sapiens_hsa049220.73866015
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73647084
100Oxytocin signaling pathway_Homo sapiens_hsa049210.73483198
101Glutamatergic synapse_Homo sapiens_hsa047240.72482112
102Alcoholism_Homo sapiens_hsa050340.70795645
103Cholinergic synapse_Homo sapiens_hsa047250.69932722
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.69880377
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69523349
106MAPK signaling pathway_Homo sapiens_hsa040100.69410795
107Rap1 signaling pathway_Homo sapiens_hsa040150.69035863
108Gap junction_Homo sapiens_hsa045400.68252480
109Nucleotide excision repair_Homo sapiens_hsa034200.68102611
110GABAergic synapse_Homo sapiens_hsa047270.67930150
111Renin secretion_Homo sapiens_hsa049240.67671973
112Axon guidance_Homo sapiens_hsa043600.67591780
113Primary immunodeficiency_Homo sapiens_hsa053400.67400975
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.66885793
115Tryptophan metabolism_Homo sapiens_hsa003800.64761912
116Insulin signaling pathway_Homo sapiens_hsa049100.64646061
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.64077603
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63919824
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63797260
120Serotonergic synapse_Homo sapiens_hsa047260.63550611
121Long-term depression_Homo sapiens_hsa047300.63523414
122Focal adhesion_Homo sapiens_hsa045100.63269841
123Herpes simplex infection_Homo sapiens_hsa051680.62797700
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62555224
125Caffeine metabolism_Homo sapiens_hsa002320.62205925
126Antigen processing and presentation_Homo sapiens_hsa046120.61904696
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61334124
128Circadian rhythm_Homo sapiens_hsa047100.60961672
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60845742
130Acute myeloid leukemia_Homo sapiens_hsa052210.60314295
131Renal cell carcinoma_Homo sapiens_hsa052110.59222521
132Salivary secretion_Homo sapiens_hsa049700.59085124
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.57784680
134Proteasome_Homo sapiens_hsa030500.56123760
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48860409
136Peroxisome_Homo sapiens_hsa041460.48186728
137Systemic lupus erythematosus_Homo sapiens_hsa053220.43439155
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.42290717
139Melanoma_Homo sapiens_hsa052180.41196102
140Steroid biosynthesis_Homo sapiens_hsa001000.38318098
141Fatty acid metabolism_Homo sapiens_hsa012120.37068659
142Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34265599
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31894845
144Retinol metabolism_Homo sapiens_hsa008300.31549622
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.30329375
146Calcium signaling pathway_Homo sapiens_hsa040200.29521834
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.28620910
148Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27970796
149Metabolic pathways_Homo sapiens_hsa011000.26927638
150Glycerolipid metabolism_Homo sapiens_hsa005610.26371771
151Type I diabetes mellitus_Homo sapiens_hsa049400.24850590
152Huntingtons disease_Homo sapiens_hsa050160.24256301
153Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23698499
154SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22283697
155N-Glycan biosynthesis_Homo sapiens_hsa005100.20754296
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20638832
157Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19560397

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