S1PR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)7.02401116
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.02401116
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.55516871
4alanine transport (GO:0032328)6.17418192
5positive regulation of gamma-delta T cell activation (GO:0046645)6.16170706
6antigen processing and presentation of endogenous antigen (GO:0019883)5.84361565
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.60765181
8thymic T cell selection (GO:0045061)5.14840300
9negative regulation of astrocyte differentiation (GO:0048712)5.12606911
10positive T cell selection (GO:0043368)5.03660493
11positive regulation of cellular amide metabolic process (GO:0034250)5.02589802
12regulation of B cell receptor signaling pathway (GO:0050855)4.97332073
13L-serine transport (GO:0015825)4.95987310
14positive thymic T cell selection (GO:0045059)4.93410356
15regulation of gamma-delta T cell differentiation (GO:0045586)4.92669274
16low-density lipoprotein particle remodeling (GO:0034374)4.90781461
17cellular response to interleukin-15 (GO:0071350)4.90109921
18T cell selection (GO:0045058)4.86949271
19negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.82417945
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.81968062
21C4-dicarboxylate transport (GO:0015740)4.76538803
22response to interleukin-15 (GO:0070672)4.76087052
23regulation of gamma-delta T cell activation (GO:0046643)4.72247221
24cellular response to cholesterol (GO:0071397)4.67058373
25leukocyte aggregation (GO:0070486)4.51060386
26tolerance induction (GO:0002507)4.50418618
27serine transport (GO:0032329)4.50171575
28regulation of T cell tolerance induction (GO:0002664)4.41079075
29* T cell migration (GO:0072678)4.35164723
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.25920567
31sodium ion export (GO:0071436)4.25130044
32cellular potassium ion homeostasis (GO:0030007)4.19107873
33L-amino acid import (GO:0043092)4.18706297
34amino acid import (GO:0043090)4.10632215
35activated T cell proliferation (GO:0050798)4.07963727
36positive regulation of triglyceride biosynthetic process (GO:0010867)4.05671542
37regulation of beta-amyloid formation (GO:1902003)4.04268039
38cellular response to sterol (GO:0036315)3.96418426
39alpha-linolenic acid metabolic process (GO:0036109)3.90827530
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.88680006
41positive regulation of tolerance induction (GO:0002645)3.77197109
42interferon-gamma production (GO:0032609)3.76199757
43glial cell proliferation (GO:0014009)3.75406041
44regulation of isotype switching to IgG isotypes (GO:0048302)3.73568262
45reverse cholesterol transport (GO:0043691)3.73113679
46regulation of tolerance induction (GO:0002643)3.71100915
47regulation of regulatory T cell differentiation (GO:0045589)3.67758922
48negative regulation of T cell mediated immunity (GO:0002710)3.67323199
49regulation of alpha-beta T cell proliferation (GO:0046640)3.64263394
50regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.58049329
51regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.57888454
52regulation of natural killer cell mediated immunity (GO:0002715)3.57888454
53negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.54747432
54chondroitin sulfate catabolic process (GO:0030207)3.54625016
55regulation of B cell differentiation (GO:0045577)3.54177928
56cell communication by electrical coupling (GO:0010644)3.53018522
57neurotransmitter-gated ion channel clustering (GO:0072578)3.51085452
58potassium ion import (GO:0010107)3.49909669
59regulation of interleukin-2 biosynthetic process (GO:0045076)3.48373269
60T cell receptor signaling pathway (GO:0050852)3.47331861
61regulation of astrocyte differentiation (GO:0048710)3.46596144
62negative regulation of leukocyte mediated immunity (GO:0002704)3.45515084
63regulation of T cell mediated cytotoxicity (GO:0001914)3.45164273
64positive regulation of B cell differentiation (GO:0045579)3.39682793
65cellular response to type I interferon (GO:0071357)3.35536175
66type I interferon signaling pathway (GO:0060337)3.35536175
67negative regulation of response to reactive oxygen species (GO:1901032)3.34035730
68positive regulation of T cell mediated cytotoxicity (GO:0001916)3.31338911
69response to type I interferon (GO:0034340)3.31169378
70cholesterol catabolic process (GO:0006707)3.25145154
71sterol catabolic process (GO:0016127)3.25145154
72cGMP-mediated signaling (GO:0019934)3.24452330
73gamma-aminobutyric acid transport (GO:0015812)3.23691509
74antigen receptor-mediated signaling pathway (GO:0050851)3.23577379
75regulation of triglyceride biosynthetic process (GO:0010866)3.23135452
76signal complex assembly (GO:0007172)3.22191546
77positive regulation of alpha-beta T cell proliferation (GO:0046641)3.19545895
78regulation of amyloid precursor protein catabolic process (GO:1902991)3.19328623
79regulation of phospholipid biosynthetic process (GO:0071071)3.18938137
80dicarboxylic acid biosynthetic process (GO:0043650)3.18849703
81regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.18132821
82linoleic acid metabolic process (GO:0043651)3.17483247
83B cell receptor signaling pathway (GO:0050853)3.17029540
84detection of other organism (GO:0098543)3.16589335
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15009321
86cellular sodium ion homeostasis (GO:0006883)3.13473707
87regulation of cholesterol biosynthetic process (GO:0045540)3.13080642
88regulation of cholesterol esterification (GO:0010872)3.12278690
89detection of bacterium (GO:0016045)3.07990714
90regulation of leukocyte mediated cytotoxicity (GO:0001910)3.07111442
91positive regulation of granulocyte differentiation (GO:0030854)3.06766938
92positive regulation of interleukin-4 production (GO:0032753)3.06321073
93dermatan sulfate metabolic process (GO:0030205)3.05076945
94positive regulation of humoral immune response (GO:0002922)3.04193475
95response to cholesterol (GO:0070723)3.03075129
96regulation of hydrogen peroxide-induced cell death (GO:1903205)3.00890870
97modulation by symbiont of host defense response (GO:0052031)3.00712462
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00712462
99modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00712462
100positive regulation by organism of defense response of other organism involved in symbiotic interact3.00712462
101modulation by symbiont of host immune response (GO:0052553)3.00712462
102positive regulation by symbiont of host defense response (GO:0052509)3.00712462
103plasma lipoprotein particle assembly (GO:0034377)2.99037694
104positive regulation of interleukin-2 production (GO:0032743)2.98156249
105positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.96929098
106mast cell activation (GO:0045576)2.96588104
107antigen processing and presentation via MHC class Ib (GO:0002475)2.96517490
108dermatan sulfate biosynthetic process (GO:0030208)2.96362635
109positive regulation of natural killer cell mediated immunity (GO:0002717)2.93765854
110response to auditory stimulus (GO:0010996)2.91765128
111plasma lipoprotein particle remodeling (GO:0034369)2.91569458
112protein-lipid complex remodeling (GO:0034368)2.91569458
113macromolecular complex remodeling (GO:0034367)2.91569458
114locomotory exploration behavior (GO:0035641)2.91276441
115plasma lipoprotein particle organization (GO:0071827)2.90019982
116cellular modified amino acid catabolic process (GO:0042219)2.88071149
117cellular extravasation (GO:0045123)2.87942191
118negative regulation of phagocytosis (GO:0050765)2.86193928
119regulation of alpha-beta T cell activation (GO:0046634)2.84380219
120regulation of cell killing (GO:0031341)2.84335416
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.83479683
122negative regulation of innate immune response (GO:0045824)2.81998172
123regulation of dendritic cell antigen processing and presentation (GO:0002604)2.81530202
124positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81159092
125positive regulation of triglyceride metabolic process (GO:0090208)2.80738721
126adenine nucleotide transport (GO:0051503)2.80283707
127negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.78540899
128negative regulation of glial cell differentiation (GO:0045686)2.78053699
129response to sterol (GO:0036314)2.75323415
130myeloid dendritic cell differentiation (GO:0043011)2.75252389
131T cell homeostasis (GO:0043029)2.75030088
132regulation of cellular amide metabolic process (GO:0034248)2.74999808
133positive regulation of cell killing (GO:0031343)2.73828829
134* lymphocyte migration (GO:0072676)2.73652182
135doxorubicin metabolic process (GO:0044598)2.73052326
136daunorubicin metabolic process (GO:0044597)2.73052326
137polyketide metabolic process (GO:0030638)2.73052326
138positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72951765
139negative regulation of interleukin-12 production (GO:0032695)2.72714747
140endothelium development (GO:0003158)2.72493886
141protein-lipid complex subunit organization (GO:0071825)2.71442537
142regulation of interleukin-4 production (GO:0032673)2.70744357
143T cell costimulation (GO:0031295)2.70289426
144atrial cardiac muscle cell action potential (GO:0086014)2.68449930
145dendritic cell chemotaxis (GO:0002407)2.68426160
146high-density lipoprotein particle remodeling (GO:0034375)2.68397190
147negative regulation of sodium ion transport (GO:0010766)2.67625924
148phospholipid efflux (GO:0033700)2.67023928
149proline transport (GO:0015824)2.66812952
150lymphocyte costimulation (GO:0031294)2.66468052
151protein-lipid complex assembly (GO:0065005)2.66041236
152interferon-gamma-mediated signaling pathway (GO:0060333)2.65646020
153NIK/NF-kappaB signaling (GO:0038061)2.65461404
154negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64384992
155regulation of defense response to virus by virus (GO:0050690)2.63471658
156response to muramyl dipeptide (GO:0032495)2.63431449
157myeloid dendritic cell activation (GO:0001773)2.62927015
158very-low-density lipoprotein particle assembly (GO:0034379)2.62548248
159ethanol oxidation (GO:0006069)2.61914271
160positive regulation of alpha-beta T cell activation (GO:0046635)2.61771812
161macrophage activation involved in immune response (GO:0002281)2.61723911
162regulation of granulocyte differentiation (GO:0030852)2.60151103
163T cell differentiation (GO:0030217)2.59606598
164negative T cell selection (GO:0043383)2.58547792
165regulation of extracellular matrix disassembly (GO:0010715)2.58490135
166dendritic cell migration (GO:0036336)2.57658530
167purine nucleotide transport (GO:0015865)2.57554648
168fatty acid homeostasis (GO:0055089)2.57345585
169positive regulation of isotype switching (GO:0045830)2.57261269
170glycogen catabolic process (GO:0005980)2.56318850
171acidic amino acid transport (GO:0015800)2.56069485
172immunoglobulin mediated immune response (GO:0016064)2.55604377
173negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.55124093
174ovulation cycle (GO:0042698)2.53618366
175leukocyte cell-cell adhesion (GO:0007159)2.53406845
176antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.51237368
177antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.51237368
178negative regulation of tissue remodeling (GO:0034104)2.50273167
179negative regulation of smoothened signaling pathway (GO:0045879)2.47746372
180negative thymic T cell selection (GO:0045060)2.47036104
181phagocytosis, recognition (GO:0006910)2.45794886
182regulation of extracellular matrix organization (GO:1903053)2.45780754
183regulation of apoptotic cell clearance (GO:2000425)2.44368942
184negative regulation of protein oligomerization (GO:0032460)2.43148410
185glutamate metabolic process (GO:0006536)2.42985971
186regulation of cholesterol metabolic process (GO:0090181)2.42221283
187regulation of cholesterol homeostasis (GO:2000188)2.40859975
188positive regulation of glycogen biosynthetic process (GO:0045725)2.40540946
189lens fiber cell development (GO:0070307)2.38251957
190glucan catabolic process (GO:0009251)2.36560479
191positive regulation of potassium ion transmembrane transport (GO:1901381)2.34881777
192regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.34433345
193positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.34141450
194potassium ion homeostasis (GO:0055075)2.33873617
195axon ensheathment in central nervous system (GO:0032291)2.32748781
196central nervous system myelination (GO:0022010)2.32748781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.53876601
2STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.30326532
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.04448256
4* MYB_26560356_Chip-Seq_TH2_Human2.82389247
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.79864570
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.76902284
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75805509
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.66115465
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64253803
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53128421
11AR_21572438_ChIP-Seq_LNCaP_Human2.48512914
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46871065
13* MAF_26560356_Chip-Seq_TH1_Human2.38623577
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35240581
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27310928
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.20098885
17UTX_26944678_Chip-Seq_JUKART_Human2.20072290
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.19605949
19* MYB_26560356_Chip-Seq_TH1_Human2.17325030
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.12947417
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10991668
22* RUNX_20019798_ChIP-Seq_JUKART_Human2.08105482
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06225555
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01248135
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96426686
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95717848
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95464049
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94821699
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94621817
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.92728670
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84689306
32* LXR_22158963_ChIP-Seq_LIVER_Mouse1.81359971
33DROSHA_22980978_ChIP-Seq_HELA_Human1.78180096
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77796608
35* MAF_26560356_Chip-Seq_TH2_Human1.76809712
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74742131
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74172795
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74172795
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.70506421
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68952202
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68562051
42SPI1_23127762_ChIP-Seq_K562_Human1.66674751
43RXR_22108803_ChIP-Seq_LS180_Human1.63471218
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62812810
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57303187
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55492934
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53636565
48CLOCK_20551151_ChIP-Seq_293T_Human1.53527060
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52934596
50KDM2B_26808549_Chip-Seq_DND41_Human1.51557450
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51546653
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51256008
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.51201938
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50787412
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.50506051
56* TCF7_22412390_ChIP-Seq_EML_Mouse1.49560485
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.49314897
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.48832369
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.46311094
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45923055
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.43947982
62VDR_24763502_ChIP-Seq_THP-1_Human1.42502756
63EZH2_22144423_ChIP-Seq_EOC_Human1.41228426
64* GATA3_26560356_Chip-Seq_TH2_Human1.41222226
65* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40520630
66BCAT_22108803_ChIP-Seq_LS180_Human1.39713189
67SPI1_23547873_ChIP-Seq_NB4_Human1.38176681
68* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35319723
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29884525
70MYC_22102868_ChIP-Seq_BL_Human1.29079376
71* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27980250
72* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27601476
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27176086
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27017508
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25611946
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25493515
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24196254
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23564203
79VDR_21846776_ChIP-Seq_THP-1_Human1.21322337
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20522895
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.20287606
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19635174
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19537431
84* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19430767
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19046164
86* ELK3_25401928_ChIP-Seq_HUVEC_Human1.17941471
87* GATA1_19941827_ChIP-Seq_MEL_Mouse1.16346041
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14758167
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12191809
90* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10839546
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09334105
92GATA1_19941826_ChIP-Seq_K562_Human1.09265163
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08639738
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08408333
95* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07549056
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06547844
97* REST_21632747_ChIP-Seq_MESCs_Mouse1.06372988
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06203411
99RARB_27405468_Chip-Seq_BRAIN_Mouse1.05794643
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05009185
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04799036
102TP53_16413492_ChIP-PET_HCT116_Human1.04310913
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.03346151
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02475365
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01664840
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01307378
107* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00812312
108CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00186338
109PU_27001747_Chip-Seq_BMDM_Mouse0.98917372
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.97301521
111RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97137133
112EZH2_27304074_Chip-Seq_ESCs_Mouse0.96986461
113TBX20_22328084_ChIP-Seq_HEART_Mouse0.96668383
114TBX20_22080862_ChIP-Seq_HEART_Mouse0.96668383
115WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96177764
116TP53_18474530_ChIP-ChIP_U2OS_Human0.95967371
117* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95071047
118* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94882658
119LXR_22292898_ChIP-Seq_THP-1_Human0.94402013
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.93902317
121TCF4_18268006_ChIP-ChIP_LS174T_Human0.93161521
122AR_25329375_ChIP-Seq_VCAP_Human0.93057376
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92777302
124VDR_24787735_ChIP-Seq_THP-1_Human0.92591411
125IRF8_22096565_ChIP-ChIP_GC-B_Human0.91687736
126FOXA2_19822575_ChIP-Seq_HepG2_Human0.90541161
127ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89677348
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88595557
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87993567
130* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86781832
131GBX2_23144817_ChIP-Seq_PC3_Human0.86204094
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85583732
133AR_19668381_ChIP-Seq_PC3_Human0.85315599
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.84978954
135EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83573726
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83500832
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83500832
138GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83305032
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82990589
140CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82659286
141* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82526390
142TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82361688
143* KDM2B_26808549_Chip-Seq_K562_Human0.82234893
144PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81905411
145FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80655303
146* KDM2B_26808549_Chip-Seq_JURKAT_Human0.80586749
147WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80444308
148SCL_19346495_ChIP-Seq_HPC-7_Human0.80309336
149REST_18959480_ChIP-ChIP_MESCs_Mouse0.80097336
150EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78876863
151* GATA2_19941826_ChIP-Seq_K562_Human0.78385621
152GATA3_27048872_Chip-Seq_THYMUS_Human0.78180500
153TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77896026
154CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76880616
155* FOXO3_23340844_ChIP-Seq_DLD1_Human0.75789168
156EP300_21415370_ChIP-Seq_HL-1_Mouse0.75511814
157SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75091986
158PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74932446
159SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.70442549
160* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.69747394
161KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.69378026
162EGR1_19374776_ChIP-ChIP_THP-1_Human0.67741410
163SMRT_27268052_Chip-Seq_Bcells_Human0.67521387
164PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67418250
165KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.67013967
166KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.67013967
167KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.67013967
168GATA1_19941827_ChIP-Seq_MEL86_Mouse0.66798052
169VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.66352494
170PU.1_20513432_ChIP-Seq_Bcells_Mouse0.65746613
171* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.65165912
172SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64957328
173GATA3_26560356_Chip-Seq_TH1_Human0.63289818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.58769010
2MP0003690_abnormal_glial_cell3.91582880
3MP0009840_abnormal_foam_cell3.48251691
4MP0003436_decreased_susceptibility_to3.37737549
5MP0003329_amyloid_beta_deposits3.37300899
6MP0003279_aneurysm3.24267875
7MP0001835_abnormal_antigen_presentation3.23303101
8MP0005000_abnormal_immune_tolerance2.85453830
9MP0009384_cardiac_valve_regurgitation2.56098244
10MP0002723_abnormal_immune_serum2.51599658
11* MP0002420_abnormal_adaptive_immunity2.51588912
12MP0009785_altered_susceptibility_to2.51525489
13MP0005025_abnormal_response_to2.51304708
14MP0001853_heart_inflammation2.50953928
15MP0000604_amyloidosis2.47013399
16* MP0001819_abnormal_immune_cell2.46435273
17MP0003075_altered_response_to2.40096659
18MP0002452_abnormal_antigen_presenting2.35473465
19MP0005646_abnormal_pituitary_gland2.27982329
20MP0005167_abnormal_blood-brain_barrier2.21421414
21MP0006082_CNS_inflammation2.20268703
22MP0009333_abnormal_splenocyte_physiolog2.20061419
23MP0004858_abnormal_nervous_system2.15392723
24MP0002405_respiratory_system_inflammati2.13804350
25MP0004859_abnormal_synaptic_plasticity2.04114719
26MP0003300_gastrointestinal_ulcer2.00476534
27MP0009780_abnormal_chondrocyte_physiolo2.00087745
28* MP0002398_abnormal_bone_marrow1.97253034
29MP0003828_pulmonary_edema1.96840159
30* MP0000716_abnormal_immune_system1.94444661
31MP0002933_joint_inflammation1.89810957
32MP0004510_myositis1.89610849
33MP0010155_abnormal_intestine_physiology1.89185901
34MP0000703_abnormal_thymus_morphology1.87133208
35MP0010329_abnormal_lipoprotein_level1.86106279
36MP0001486_abnormal_startle_reflex1.85979093
37MP0001502_abnormal_circadian_rhythm1.82696777
38MP0005360_urolithiasis1.79417863
39MP0004885_abnormal_endolymph1.78988307
40MP0002148_abnormal_hypersensitivity_rea1.78739899
41MP0002166_altered_tumor_susceptibility1.77776234
42MP0001851_eye_inflammation1.76110359
43MP0005332_abnormal_amino_acid1.73563969
44MP0001533_abnormal_skeleton_physiology1.72953176
45MP0003633_abnormal_nervous_system1.71972422
46MP0004130_abnormal_muscle_cell1.70089388
47MP0002139_abnormal_hepatobiliary_system1.69066544
48MP0002909_abnormal_adrenal_gland1.62507457
49MP0003866_abnormal_defecation1.60957529
50MP0008569_lethality_at_weaning1.60812331
51MP0000689_abnormal_spleen_morphology1.60725172
52MP0004947_skin_inflammation1.60461631
53MP0002722_abnormal_immune_system1.60409545
54MP0010368_abnormal_lymphatic_system1.60334872
55MP0000685_abnormal_immune_system1.56552227
56MP0002638_abnormal_pupillary_reflex1.52456329
57MP0001879_abnormal_lymphatic_vessel1.52434543
58MP0004215_abnormal_myocardial_fiber1.49792930
59MP0001845_abnormal_inflammatory_respons1.48686719
60MP0005166_decreased_susceptibility_to1.47421683
61MP0005165_increased_susceptibility_to1.44624227
62* MP0002429_abnormal_blood_cell1.44410011
63MP0005365_abnormal_bile_salt1.43869393
64MP0003763_abnormal_thymus_physiology1.42397156
65MP0003635_abnormal_synaptic_transmissio1.38419997
66MP0002009_preneoplasia1.38082959
67MP0003634_abnormal_glial_cell1.33982624
68MP0005670_abnormal_white_adipose1.32805666
69MP0006054_spinal_hemorrhage1.32578524
70MP0005464_abnormal_platelet_physiology1.31568630
71MP0005377_hearing/vestibular/ear_phenot1.27761839
72MP0003878_abnormal_ear_physiology1.27761839
73MP0003631_nervous_system_phenotype1.25417248
74MP0009764_decreased_sensitivity_to1.22494376
75MP0005595_abnormal_vascular_smooth1.19973719
76MP0000343_altered_response_to1.16774113
77MP0003011_delayed_dark_adaptation1.16267295
78MP0001440_abnormal_grooming_behavior1.15949620
79MP0003191_abnormal_cellular_cholesterol1.14335654
80MP0001873_stomach_inflammation1.12015336
81MP0008260_abnormal_autophagy1.11996205
82MP0002064_seizures1.11803399
83MP0005310_abnormal_salivary_gland1.10162968
84MP0002090_abnormal_vision1.09047475
85MP0002572_abnormal_emotion/affect_behav1.08507383
86MP0009745_abnormal_behavioral_response1.08283932
87MP0005387_immune_system_phenotype1.07787239
88MP0001790_abnormal_immune_system1.07787239
89MP0003448_altered_tumor_morphology1.07428987
90MP0003137_abnormal_impulse_conducting1.07228147
91MP0005584_abnormal_enzyme/coenzyme_acti1.05027430
92MP0003183_abnormal_peptide_metabolism1.04302466
93MP0005647_abnormal_sex_gland1.03324818
94MP0002006_tumorigenesis1.03064574
95MP0004484_altered_response_of1.02557555
96MP0008469_abnormal_protein_level1.02290000
97MP0004381_abnormal_hair_follicle1.01718106
98MP0000858_altered_metastatic_potential1.01360773
99MP0002118_abnormal_lipid_homeostasis0.99923977
100MP0001958_emphysema0.99863737
101MP0002971_abnormal_brown_adipose0.99794980
102MP0004883_abnormal_blood_vessel0.98656524
103MP0002972_abnormal_cardiac_muscle0.96253874
104* MP0003091_abnormal_cell_migration0.96206153
105MP0002063_abnormal_learning/memory/cond0.96135940
106MP0000566_synostosis0.96030996
107MP0003632_abnormal_nervous_system0.93124189
108MP0005058_abnormal_lysosome_morphology0.93043499
109MP0001984_abnormal_olfaction0.92571743
110MP0001348_abnormal_lacrimal_gland0.92351871
111MP0002822_catalepsy0.91129932
112MP0003724_increased_susceptibility_to0.91054581
113MP0008875_abnormal_xenobiotic_pharmacok0.90168182
114MP0003303_peritoneal_inflammation0.89473855
115MP0009046_muscle_twitch0.88493857
116MP0000249_abnormal_blood_vessel0.86572318
117MP0005171_absent_coat_pigmentation0.85844502
118MP0002138_abnormal_hepatobiliary_system0.85812197
119MP0001501_abnormal_sleep_pattern0.84769731
120* MP0000767_abnormal_smooth_muscle0.84184903
121MP0000609_abnormal_liver_physiology0.83602496
122MP0005423_abnormal_somatic_nervous0.83451946
123MP0005671_abnormal_response_to0.83127993
124MP0002332_abnormal_exercise_endurance0.83070257
125MP0005164_abnormal_response_to0.80810926
126MP0000465_gastrointestinal_hemorrhage0.80021396
127MP0009763_increased_sensitivity_to0.79236495
128MP0003646_muscle_fatigue0.75931850
129MP0009278_abnormal_bone_marrow0.75855578
130MP0005666_abnormal_adipose_tissue0.75479288
131MP0002133_abnormal_respiratory_system0.75318113
132MP0005388_respiratory_system_phenotype0.75318113
133MP0004036_abnormal_muscle_relaxation0.75081186
134MP0001663_abnormal_digestive_system0.74042167
135MP0002998_abnormal_bone_remodeling0.73535820
136MP0005390_skeleton_phenotype0.73147307
137MP0002419_abnormal_innate_immunity0.72507688
138MP0005451_abnormal_body_composition0.72343460
139MP0002295_abnormal_pulmonary_circulatio0.71899847
140MP0002557_abnormal_social/conspecific_i0.71606206
141MP0009115_abnormal_fat_cell0.69883056
142MP0000920_abnormal_myelination0.69826105
143MP0001800_abnormal_humoral_immune0.69367950
144MP0000751_myopathy0.69155572
145* MP0002127_abnormal_cardiovascular_syste0.68912382
146MP0003045_fibrosis0.68819000
147MP0002733_abnormal_thermal_nociception0.68213864
148MP0003638_abnormal_response/metabolism_0.68061737
149MP0002089_abnormal_postnatal_growth/wei0.67766862
150MP0006138_congestive_heart_failure0.67715064
151* MP0005385_cardiovascular_system_phenoty0.66713994
152* MP0001544_abnormal_cardiovascular_syste0.66713994
153MP0002928_abnormal_bile_duct0.65881069
154MP0002277_abnormal_respiratory_mucosa0.64189233
155MP0008004_abnormal_stomach_pH0.63849856
156MP0003795_abnormal_bone_structure0.52642536
157MP0004084_abnormal_cardiac_muscle0.50191386
158* MP0008874_decreased_physiological_sensi0.49477671

Predicted human phenotypes

RankGene SetZ-score
1Megalencephaly (HP:0001355)6.68454912
2Aplasia involving bones of the extremities (HP:0009825)5.74614572
3Aplasia involving bones of the upper limbs (HP:0009823)5.74614572
4Aplasia of the phalanges of the hand (HP:0009802)5.74614572
5Eczematoid dermatitis (HP:0000976)5.71102918
6Neurofibrillary tangles (HP:0002185)5.40357543
7Abnormality of T cell number (HP:0011839)5.24281819
8Elevated erythrocyte sedimentation rate (HP:0003565)5.20049761
9Myositis (HP:0100614)4.96795337
10Stomatitis (HP:0010280)4.84204209
11Abnormality of binocular vision (HP:0011514)4.51768245
12Diplopia (HP:0000651)4.51768245
13Hemiplegia (HP:0002301)4.22964620
14Orchitis (HP:0100796)4.20034889
15Optic neuritis (HP:0100653)4.19288643
16Retrobulbar optic neuritis (HP:0100654)4.19288643
17Abnormality of secondary sexual hair (HP:0009888)4.12418103
18Abnormality of the axillary hair (HP:0100134)4.12418103
19Back pain (HP:0003418)4.04773083
20Cerebral inclusion bodies (HP:0100314)4.01005123
21Recurrent bacterial skin infections (HP:0005406)3.92169474
22Recurrent abscess formation (HP:0002722)3.84226263
23Abnormality of T cells (HP:0002843)3.78656653
24Recurrent bronchitis (HP:0002837)3.73663841
25Hyperlipoproteinemia (HP:0010980)3.70183548
26Recurrent fungal infections (HP:0002841)3.65393280
27Clumsiness (HP:0002312)3.62173587
28Abnormality of macrophages (HP:0004311)3.60073091
29Hypoplastic left heart (HP:0004383)3.56322013
30Pustule (HP:0200039)3.53368058
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.52121287
32Severe combined immunodeficiency (HP:0004430)3.51526515
33Pseudobulbar signs (HP:0002200)3.42809097
34Hypoalphalipoproteinemia (HP:0003233)3.41517057
35Hemiparesis (HP:0001269)3.40731056
36Xanthomatosis (HP:0000991)3.40417748
37Hyperglycinuria (HP:0003108)3.39469828
38Panhypogammaglobulinemia (HP:0003139)3.35665634
39Encephalitis (HP:0002383)3.30694921
40Polycythemia (HP:0001901)3.29825436
41Meningitis (HP:0001287)3.26481186
42IgG deficiency (HP:0004315)3.23657411
43Increased IgM level (HP:0003496)3.22193379
44Lymphopenia (HP:0001888)3.18958405
45Recurrent gram-negative bacterial infections (HP:0005420)3.16272695
46Autoimmune hemolytic anemia (HP:0001890)3.14579332
47Adactyly (HP:0009776)3.14372762
48Keratoconjunctivitis sicca (HP:0001097)3.11581909
49Abnormality of the nasal mucosa (HP:0000433)3.10683065
50Eosinophilia (HP:0001880)3.08829621
51Vasculitis (HP:0002633)3.07978788
52Abnormality of glycine metabolism (HP:0010895)3.06090387
53Abnormality of serine family amino acid metabolism (HP:0010894)3.06090387
54Leukocytosis (HP:0001974)3.05983524
55Recurrent viral infections (HP:0004429)3.05411332
56Abnormality of eosinophils (HP:0001879)3.05403666
57Mediastinal lymphadenopathy (HP:0100721)3.05048177
58Humeroradial synostosis (HP:0003041)2.99644903
59Synostosis involving the elbow (HP:0003938)2.99644903
60Short hallux (HP:0010109)2.97436440
61Granulocytopenia (HP:0001913)2.95745131
62Increased IgE level (HP:0003212)2.95356005
63Mesangial abnormality (HP:0001966)2.91754836
64Pulmonary infiltrates (HP:0002113)2.90619659
65Keratoconjunctivitis (HP:0001096)2.89919628
66Gastrointestinal infarctions (HP:0005244)2.88534366
67Abnormality of cells of the lymphoid lineage (HP:0012140)2.88371311
68Status epilepticus (HP:0002133)2.87356395
69Tetraparesis (HP:0002273)2.83587076
70Recurrent cutaneous fungal infections (HP:0011370)2.81887351
71Chronic mucocutaneous candidiasis (HP:0002728)2.81887351
72Inflammation of the large intestine (HP:0002037)2.76905970
73Agammaglobulinemia (HP:0004432)2.75052499
74Hemoptysis (HP:0002105)2.73918741
75Recurrent skin infections (HP:0001581)2.73323530
76Aplasia/Hypoplasia of the hallux (HP:0008362)2.73040609
77Ketoacidosis (HP:0001993)2.71981763
78Chest pain (HP:0100749)2.69913520
79Pulmonary embolism (HP:0002204)2.68048419
80Amyloidosis (HP:0011034)2.67925354
81IgM deficiency (HP:0002850)2.66951787
82Colitis (HP:0002583)2.62390120
83Sensorimotor neuropathy (HP:0007141)2.60982149
84Combined immunodeficiency (HP:0005387)2.60392229
85Gastrointestinal inflammation (HP:0004386)2.60214234
86Atrioventricular block (HP:0001678)2.58596330
87Papilledema (HP:0001085)2.54016100
88Hypoplastic heart (HP:0001961)2.53687313
89Cellulitis (HP:0100658)2.53475132
90Prolonged bleeding time (HP:0003010)2.48495272
91Hypergammaglobulinemia (HP:0010702)2.43220998
92Papilloma (HP:0012740)2.40941002
93Verrucae (HP:0200043)2.40941002
94Slow saccadic eye movements (HP:0000514)2.40475335
95Obstructive lung disease (HP:0006536)2.39887246
96Chronic obstructive pulmonary disease (HP:0006510)2.39887246
97Joint swelling (HP:0001386)2.36232538
98Long nose (HP:0003189)2.36201256
99Nasal polyposis (HP:0100582)2.34493111
100Microcytic anemia (HP:0001935)2.34251939
101Exercise-induced myalgia (HP:0003738)2.33028672
102Myocardial infarction (HP:0001658)2.32884948
103Absent hair (HP:0002298)2.32771891
104Abnormality of T cell physiology (HP:0011840)2.32757268
105Onycholysis (HP:0001806)2.28245559
106Chronic diarrhea (HP:0002028)2.27615276
107Epistaxis (HP:0000421)2.24387113
108Ketosis (HP:0001946)2.23283486
109Hyperammonemia (HP:0001987)2.21925449
110Autoimmune thrombocytopenia (HP:0001973)2.20426552
111Gingivitis (HP:0000230)2.17762495
112Esophageal varix (HP:0002040)2.16581782
113Abnormality of the middle phalanges of the toes (HP:0010183)2.13751602
114Deep venous thrombosis (HP:0002625)2.12700687
115Interstitial pulmonary disease (HP:0006530)2.11886020
116Muscle fiber splitting (HP:0003555)2.10652394
117Abnormality of the pleura (HP:0002103)2.10332257
118Hypolipoproteinemia (HP:0010981)2.09976013
119Late onset (HP:0003584)2.09939773
120Stroke (HP:0001297)2.08668628
121Supranuclear gaze palsy (HP:0000605)2.07737096
122Thyroiditis (HP:0100646)2.07217094
123Sepsis (HP:0100806)2.06597761
124Polygenic inheritance (HP:0010982)2.04483158
125Hypoplasia of the thymus (HP:0000778)2.04400021
126Stomach cancer (HP:0012126)2.03885310
127Hyperglycinemia (HP:0002154)2.03832245
128Hydroxyprolinuria (HP:0003080)2.02345222
129Abnormality of proline metabolism (HP:0010907)2.02345222
130Paraparesis (HP:0002385)2.02105819
131Gastrointestinal stroma tumor (HP:0100723)2.01475636
132Hematochezia (HP:0002573)2.00811025
133Heart block (HP:0012722)1.99736909
134Spontaneous hematomas (HP:0007420)1.99535059
135Large for gestational age (HP:0001520)1.99158785
136Confusion (HP:0001289)1.98288066
137Arterial thrombosis (HP:0004420)1.97660307
138Vertigo (HP:0002321)1.96824010
139Difficulty running (HP:0009046)1.94741989
140Broad metatarsal (HP:0001783)1.94435744
141Chronic sinusitis (HP:0011109)1.93729652
142Abnormality of B cell number (HP:0010975)1.92316985
143Mixed hearing impairment (HP:0000410)1.91393772
144Asymmetric septal hypertrophy (HP:0001670)1.90551551
145Conjunctival telangiectasia (HP:0000524)1.89732967
146Absent toe (HP:0010760)1.89295715
147Split foot (HP:0001839)1.89233170
148Episodic fever (HP:0001954)1.88295919
149Facial shape deformation (HP:0011334)1.87065120
150Potter facies (HP:0002009)1.87065120
151Bronchitis (HP:0012387)1.86526991
152Emphysema (HP:0002097)1.84177920
153Dementia (HP:0000726)1.84057875
154Increased CSF protein (HP:0002922)1.83485503
155Hypoproteinemia (HP:0003075)1.83430567
156B lymphocytopenia (HP:0010976)1.82382415
157Mitral stenosis (HP:0001718)1.82273716
158Multifactorial inheritance (HP:0001426)1.81881267
159Visceral angiomatosis (HP:0100761)1.81866634
160Acne (HP:0001061)1.81585913
161Arterial tortuosity (HP:0005116)1.81440478
162Urticaria (HP:0001025)1.80488825
163Hypoglycemic coma (HP:0001325)1.80324472
164Progressive neurologic deterioration (HP:0002344)1.78032679
165Abnormality of the dental pulp (HP:0006479)1.76778002
166Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.76306696
167Abnormal atrioventricular conduction (HP:0005150)1.76025358
168Rigidity (HP:0002063)1.74875020
169Hypoglycemic seizures (HP:0002173)1.74673383
170Hemangiomatosis (HP:0007461)1.74646657
171Chronic otitis media (HP:0000389)1.70999310
172Epileptic encephalopathy (HP:0200134)1.70482165
173Hypertriglyceridemia (HP:0002155)1.69083498
174Narrow nasal bridge (HP:0000446)1.68526410
175Ectopia lentis (HP:0001083)1.67319038
176Delayed CNS myelination (HP:0002188)1.67224747
177Postural instability (HP:0002172)1.65167807
178Blepharitis (HP:0000498)1.64506632
179Broad alveolar ridges (HP:0000187)1.64490880
180Dry hair (HP:0011359)1.63779793
181Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.63369240
182Hypercholesterolemia (HP:0003124)1.62842034
183Fibular aplasia (HP:0002990)1.62042479
184Abnormality of nail color (HP:0100643)1.61773659
185Focal motor seizures (HP:0011153)1.61494009
186T lymphocytopenia (HP:0005403)1.61240145
187Vascular tortuosity (HP:0004948)1.60276182
188Craniofacial hyperostosis (HP:0004493)1.59839875
189Bronchomalacia (HP:0002780)1.59389170
190Athetosis (HP:0002305)1.58117646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.70504681
2EPHA44.67495862
3PHKG13.27605280
4PHKG23.27605280
5TRIB33.16254046
6SIK12.84516805
7TIE12.62264049
8NTRK22.42163943
9RIPK42.36074697
10TNIK2.21388453
11GRK62.09915671
12MAPK121.99863835
13MAP4K11.92948752
14CAMKK21.88347383
15PRKD31.85744288
16TAOK31.85494916
17MUSK1.81552180
18MAP3K131.76974438
19KDR1.70384475
20SYK1.62696303
21ERN11.60758567
22FGFR31.59825851
23FGFR41.53618680
24TGFBR21.49792032
25RIPK11.48375550
26BLK1.48082830
27TXK1.44080509
28JAK31.42178611
29PRKCH1.37222718
30SGK21.35931203
31JAK11.33219558
32IRAK31.32222441
33IRAK41.31697239
34SGK31.31578021
35TESK21.28967251
36EPHA31.28590709
37MAPK71.27437417
38NLK1.24474605
39ITK1.21569506
40FGFR21.21320168
41STK101.17817493
42SIK31.16264406
43MAP2K31.15436441
44MAP3K71.11053639
45TYK21.09223729
46PRKD21.03730024
47PASK1.03592578
48DMPK1.02805483
49PRKCQ1.01812920
50LRRK21.00838586
51SGK4940.94435054
52SGK2230.94435054
53MAP3K140.93008381
54MAP3K110.93004855
55TYRO30.91383147
56MOS0.91165237
57MAP3K100.88122924
58FES0.85158101
59SIK20.83519458
60BMPR20.83395709
61CSK0.80346858
62MAP3K30.79842648
63IKBKE0.79144198
64MAP3K10.77577719
65NEK90.76349625
66HCK0.76007044
67IRAK10.75659409
68MARK30.74395405
69PTK60.73932639
70IGF1R0.73678804
71PRPF4B0.72316892
72MAPK150.71754618
73IKBKB0.71635798
74EPHB10.70588662
75STK380.68871889
76JAK20.66954076
77PIM10.66820533
78PDK10.66246739
79CSF1R0.65628550
80TAOK20.65384265
81NTRK30.65293013
82FGR0.63696917
83BCKDK0.62935073
84PRKD10.62741849
85PINK10.62197983
86TTN0.61887996
87PDGFRA0.61277213
88PRKAA20.60955197
89INSRR0.60529795
90KSR20.60036206
91FGFR10.59837640
92MST40.59695863
93HIPK20.59184313
94YES10.58948480
95PKN20.58406288
96PDPK10.54889560
97PIK3CG0.54769300
98GRK70.54614223
99TNK20.54029458
100PAK60.53251917
101CAMK40.53127040
102CAMKK10.51990749
103PDGFRB0.51754785
104CDK50.51534173
105CAMK1D0.51015673
106LCK0.51012951
107CAMK1G0.50215320
108ADRBK10.48503873
109TBK10.48376335
110ZAP700.48144661
111TAOK10.47739622
112MAPK40.47639416
113UHMK10.47211440
114MARK20.46607394
115ROCK10.44349620
116FYN0.43143135
117PTK2B0.43002799
118MINK10.42611556
119SRC0.42428259
120MAPK110.42009010
121KIT0.41646333
122DYRK1B0.40732267
123CDC42BPA0.40666371
124ROCK20.39636100
125GRK10.39309197
126CDK40.38479281
127SGK10.37059212
128PDK30.36961216
129PDK40.36961216
130TEC0.36781950
131LYN0.36458431
132PRKACG0.36176282
133PRKCE0.35768980
134INSR0.35564231
135PRKCG0.35272616
136MELK0.34909069
137BTK0.34821676
138EPHB20.34399433
139GRK50.33757191
140PAK30.33714397
141DYRK1A0.33292522
142EGFR0.33059761

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009106.34929183
2Fatty acid biosynthesis_Homo sapiens_hsa000614.33541016
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.97504455
4Fatty acid degradation_Homo sapiens_hsa000712.77858489
5Fatty acid metabolism_Homo sapiens_hsa012122.72924598
6Graft-versus-host disease_Homo sapiens_hsa053322.58692128
7Allograft rejection_Homo sapiens_hsa053302.51717590
8Autoimmune thyroid disease_Homo sapiens_hsa053202.40215095
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39507768
10Antigen processing and presentation_Homo sapiens_hsa046122.05595675
11PPAR signaling pathway_Homo sapiens_hsa033201.99239165
12Measles_Homo sapiens_hsa051621.98918556
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.93347754
14Hematopoietic cell lineage_Homo sapiens_hsa046401.83576983
15Viral myocarditis_Homo sapiens_hsa054161.83513431
16Leishmaniasis_Homo sapiens_hsa051401.81201912
17Type I diabetes mellitus_Homo sapiens_hsa049401.58788920
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58668068
19Propanoate metabolism_Homo sapiens_hsa006401.56993978
20Bile secretion_Homo sapiens_hsa049761.55909178
21Arginine biosynthesis_Homo sapiens_hsa002201.53715210
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.50756056
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.49290506
24TNF signaling pathway_Homo sapiens_hsa046681.48701615
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45627343
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36125366
27Acute myeloid leukemia_Homo sapiens_hsa052211.31771750
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31483689
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.29155092
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28999876
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27501778
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27383328
33Toxoplasmosis_Homo sapiens_hsa051451.25176482
34Complement and coagulation cascades_Homo sapiens_hsa046101.20758488
35Salivary secretion_Homo sapiens_hsa049701.17611178
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.16988282
37Tuberculosis_Homo sapiens_hsa051521.16422377
38Caffeine metabolism_Homo sapiens_hsa002321.15447176
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10851694
40Hepatitis B_Homo sapiens_hsa051611.07566927
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07560975
42Glutamatergic synapse_Homo sapiens_hsa047241.06891200
43Influenza A_Homo sapiens_hsa051641.05076531
44Peroxisome_Homo sapiens_hsa041461.05031816
45Gastric acid secretion_Homo sapiens_hsa049711.04989385
46VEGF signaling pathway_Homo sapiens_hsa043701.04040609
47Platelet activation_Homo sapiens_hsa046111.03541232
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02247304
49Herpes simplex infection_Homo sapiens_hsa051681.01775285
50Dorso-ventral axis formation_Homo sapiens_hsa043201.01459461
51GABAergic synapse_Homo sapiens_hsa047270.98768212
52Primary immunodeficiency_Homo sapiens_hsa053400.97000793
53Renal cell carcinoma_Homo sapiens_hsa052110.94445024
54Glycerolipid metabolism_Homo sapiens_hsa005610.93170438
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90844647
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88940534
57Pertussis_Homo sapiens_hsa051330.88865488
58Pancreatic cancer_Homo sapiens_hsa052120.88340876
59Insulin secretion_Homo sapiens_hsa049110.87376706
60Shigellosis_Homo sapiens_hsa051310.86008875
61Circadian rhythm_Homo sapiens_hsa047100.85872054
62HTLV-I infection_Homo sapiens_hsa051660.85695900
63Nicotine addiction_Homo sapiens_hsa050330.85679713
64Non-small cell lung cancer_Homo sapiens_hsa052230.84889447
65Tryptophan metabolism_Homo sapiens_hsa003800.84511262
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83619932
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.80550475
68Apoptosis_Homo sapiens_hsa042100.80428766
69Colorectal cancer_Homo sapiens_hsa052100.79801612
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78646235
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78620558
72ABC transporters_Homo sapiens_hsa020100.78485920
73Rheumatoid arthritis_Homo sapiens_hsa053230.77781144
74Morphine addiction_Homo sapiens_hsa050320.77432604
75African trypanosomiasis_Homo sapiens_hsa051430.77410558
76Notch signaling pathway_Homo sapiens_hsa043300.77357517
77Asthma_Homo sapiens_hsa053100.76622250
78Steroid biosynthesis_Homo sapiens_hsa001000.75743431
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75507192
80Malaria_Homo sapiens_hsa051440.74806726
81Prion diseases_Homo sapiens_hsa050200.74736666
82Hepatitis C_Homo sapiens_hsa051600.74665976
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.74555584
84Butanoate metabolism_Homo sapiens_hsa006500.73925160
85MAPK signaling pathway_Homo sapiens_hsa040100.72582364
86Endocytosis_Homo sapiens_hsa041440.72530186
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71708625
88Prolactin signaling pathway_Homo sapiens_hsa049170.71707752
89Legionellosis_Homo sapiens_hsa051340.70370637
90Circadian entrainment_Homo sapiens_hsa047130.70018354
91Fatty acid elongation_Homo sapiens_hsa000620.70004480
92* FoxO signaling pathway_Homo sapiens_hsa040680.70004368
93Chronic myeloid leukemia_Homo sapiens_hsa052200.68939657
94Insulin resistance_Homo sapiens_hsa049310.68080513
95Calcium signaling pathway_Homo sapiens_hsa040200.67562169
96Ras signaling pathway_Homo sapiens_hsa040140.67114350
97Cocaine addiction_Homo sapiens_hsa050300.66567525
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66105236
99Choline metabolism in cancer_Homo sapiens_hsa052310.65738752
100Endometrial cancer_Homo sapiens_hsa052130.65488717
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64597675
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63993234
103cAMP signaling pathway_Homo sapiens_hsa040240.63049774
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.62218127
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.60267883
106Staphylococcus aureus infection_Homo sapiens_hsa051500.60123123
107Phagosome_Homo sapiens_hsa041450.59516498
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58623545
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58493936
110HIF-1 signaling pathway_Homo sapiens_hsa040660.58445379
111Renin secretion_Homo sapiens_hsa049240.57751937
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57289553
113Regulation of autophagy_Homo sapiens_hsa041400.57176335
114Rap1 signaling pathway_Homo sapiens_hsa040150.56981750
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56228737
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56194242
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56169999
118B cell receptor signaling pathway_Homo sapiens_hsa046620.56000984
119Salmonella infection_Homo sapiens_hsa051320.55302357
120Glucagon signaling pathway_Homo sapiens_hsa049220.54494289
121Olfactory transduction_Homo sapiens_hsa047400.52779444
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52733182
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52433176
124Pancreatic secretion_Homo sapiens_hsa049720.52402246
125Sulfur metabolism_Homo sapiens_hsa009200.52352248
126Inositol phosphate metabolism_Homo sapiens_hsa005620.52150006
127* Sphingolipid signaling pathway_Homo sapiens_hsa040710.52097764
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51925844
129T cell receptor signaling pathway_Homo sapiens_hsa046600.51417700
130Dilated cardiomyopathy_Homo sapiens_hsa054140.51139630
131Long-term potentiation_Homo sapiens_hsa047200.51074181
132Epstein-Barr virus infection_Homo sapiens_hsa051690.50468870
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50101103
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49907930
135Biosynthesis of amino acids_Homo sapiens_hsa012300.49347372
136beta-Alanine metabolism_Homo sapiens_hsa004100.49022432
137Viral carcinogenesis_Homo sapiens_hsa052030.48667713
138Carbon metabolism_Homo sapiens_hsa012000.48406161
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47956124
140Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47432123
141Starch and sucrose metabolism_Homo sapiens_hsa005000.47337237
142GnRH signaling pathway_Homo sapiens_hsa049120.46806865
143Estrogen signaling pathway_Homo sapiens_hsa049150.45860157
144Focal adhesion_Homo sapiens_hsa045100.45603315
145Oxytocin signaling pathway_Homo sapiens_hsa049210.45463209
146Vitamin digestion and absorption_Homo sapiens_hsa049770.45187170
147Arginine and proline metabolism_Homo sapiens_hsa003300.44821202
148Osteoclast differentiation_Homo sapiens_hsa043800.43270024
149ErbB signaling pathway_Homo sapiens_hsa040120.42611514
150Mineral absorption_Homo sapiens_hsa049780.42125711
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41257241
152Melanogenesis_Homo sapiens_hsa049160.40384058
153Sulfur relay system_Homo sapiens_hsa041220.40075375
154Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40069446
155Thyroid hormone synthesis_Homo sapiens_hsa049180.40037131
156Pyruvate metabolism_Homo sapiens_hsa006200.39491621
157mTOR signaling pathway_Homo sapiens_hsa041500.38770036
158Glioma_Homo sapiens_hsa052140.38718483
159Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37956154
160Fructose and mannose metabolism_Homo sapiens_hsa000510.36217633
161Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35785974
162Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35651432
163Lysosome_Homo sapiens_hsa041420.33471851
164Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33313056
165Lysine degradation_Homo sapiens_hsa003100.32214214
166Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31487230
167Cholinergic synapse_Homo sapiens_hsa047250.30540537
168Chemokine signaling pathway_Homo sapiens_hsa040620.30539299
169Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30277997
170Pentose phosphate pathway_Homo sapiens_hsa000300.29393990
171Glycosaminoglycan degradation_Homo sapiens_hsa005310.28844983

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