S1PR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.55563911
2protein complex biogenesis (GO:0070271)5.33989476
3mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.92644183
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.92644183
5NADH dehydrogenase complex assembly (GO:0010257)4.92644183
6mitochondrial respiratory chain complex assembly (GO:0033108)4.90812034
7water-soluble vitamin biosynthetic process (GO:0042364)4.63799411
8platelet dense granule organization (GO:0060155)4.24587758
9DNA deamination (GO:0045006)4.08601407
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.03502104
11indolalkylamine metabolic process (GO:0006586)3.84566530
12cytochrome complex assembly (GO:0017004)3.74937085
13negative regulation of telomere maintenance (GO:0032205)3.70578424
14protein neddylation (GO:0045116)3.65960771
15negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.47671325
16kynurenine metabolic process (GO:0070189)3.45785200
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.33643317
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.33643317
19modulation by symbiont of host immune response (GO:0052553)3.33643317
20positive regulation by symbiont of host defense response (GO:0052509)3.33643317
21modulation by symbiont of host defense response (GO:0052031)3.33643317
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.33643317
23regulation of mesoderm development (GO:2000380)3.33117857
24chaperone-mediated protein transport (GO:0072321)3.32582394
25positive regulation of gastrulation (GO:2000543)3.25468197
26protein-cofactor linkage (GO:0018065)3.25202935
27primary amino compound metabolic process (GO:1901160)3.22437566
28tryptophan catabolic process (GO:0006569)3.22248502
29indole-containing compound catabolic process (GO:0042436)3.22248502
30indolalkylamine catabolic process (GO:0046218)3.22248502
31serotonin metabolic process (GO:0042428)3.20493648
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18962959
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.18962959
34protein polyglutamylation (GO:0018095)3.18506650
35positive regulation of SMAD protein import into nucleus (GO:0060391)3.14689305
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09659101
37DNA unwinding involved in DNA replication (GO:0006268)3.08550049
38wound healing, spreading of epidermal cells (GO:0035313)3.08236221
39negative regulation of transcription regulatory region DNA binding (GO:2000678)3.06414994
40cytidine catabolic process (GO:0006216)3.06023629
41cytidine deamination (GO:0009972)3.06023629
42cytidine metabolic process (GO:0046087)3.06023629
43ribosomal small subunit assembly (GO:0000028)3.05431303
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.03569839
45sulfation (GO:0051923)3.03252349
46mannosylation (GO:0097502)3.02345569
47ATP synthesis coupled proton transport (GO:0015986)3.02235637
48energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02235637
49monoubiquitinated protein deubiquitination (GO:0035520)3.01756414
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00602317
51regulation of SMAD protein import into nucleus (GO:0060390)2.99872182
52positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.98065322
53formation of translation preinitiation complex (GO:0001731)2.98040599
54positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.96434067
55regulation of interferon-beta biosynthetic process (GO:0045357)2.95900606
56response to pheromone (GO:0019236)2.95670551
57indole-containing compound metabolic process (GO:0042430)2.90344161
58retinal ganglion cell axon guidance (GO:0031290)2.90240426
59positive regulation of interferon-alpha production (GO:0032727)2.90226284
60isotype switching (GO:0045190)2.87453200
61somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.87453200
62somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.87453200
63pseudouridine synthesis (GO:0001522)2.87442349
64regulation of protein heterodimerization activity (GO:0043497)2.87031896
65negative regulation of systemic arterial blood pressure (GO:0003085)2.87031021
66respiratory chain complex IV assembly (GO:0008535)2.86715648
67negative regulation of response to food (GO:0032096)2.86019673
68negative regulation of appetite (GO:0032099)2.86019673
69intracellular protein transmembrane import (GO:0044743)2.85082769
70cell proliferation in forebrain (GO:0021846)2.84132294
71L-fucose catabolic process (GO:0042355)2.81985705
72fucose catabolic process (GO:0019317)2.81985705
73L-fucose metabolic process (GO:0042354)2.81985705
74DNA strand elongation involved in DNA replication (GO:0006271)2.80140064
75positive regulation of defense response to virus by host (GO:0002230)2.79464877
76Arp2/3 complex-mediated actin nucleation (GO:0034314)2.78562486
77T cell apoptotic process (GO:0070231)2.77943887
78cellular biogenic amine catabolic process (GO:0042402)2.77378503
79amine catabolic process (GO:0009310)2.77378503
80parturition (GO:0007567)2.77309101
81regulation of interferon-alpha production (GO:0032647)2.76797788
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75614622
83gamma-aminobutyric acid transport (GO:0015812)2.75395125
84membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.72893542
85multicellular organism reproduction (GO:0032504)2.72133180
86negative regulation of gene silencing (GO:0060969)2.72019026
87response to laminar fluid shear stress (GO:0034616)2.70974891
88pinocytosis (GO:0006907)2.70580309
89folic acid-containing compound biosynthetic process (GO:0009396)2.69818123
90antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.69497892
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69497892
92natural killer cell mediated cytotoxicity (GO:0042267)2.68832034
93natural killer cell mediated immunity (GO:0002228)2.68832034
94base-excision repair, AP site formation (GO:0006285)2.68724373
95cell adhesion mediated by integrin (GO:0033627)2.68525414
96tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67739294
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67739294
98antigen processing and presentation of endogenous antigen (GO:0019883)2.67718950
99epithelial cilium movement (GO:0003351)2.66923138
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66785316
101immunoglobulin mediated immune response (GO:0016064)2.66666959
102negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.66349856
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66265383
104glyoxylate metabolic process (GO:0046487)2.66210503
105endoderm formation (GO:0001706)2.65529153
106apoptotic cell clearance (GO:0043277)2.65095182
107viral transcription (GO:0019083)2.64650616
108nonmotile primary cilium assembly (GO:0035058)2.62366119
109negative regulation of phagocytosis (GO:0050765)2.61896709
110DNA strand elongation (GO:0022616)2.61543401
111telomere maintenance via semi-conservative replication (GO:0032201)2.60013538
112mitotic nuclear envelope disassembly (GO:0007077)2.59650497
113kidney morphogenesis (GO:0060993)2.59442124
114translational termination (GO:0006415)2.58584875
115negative regulation of mast cell activation (GO:0033004)2.57859203
116sequestering of actin monomers (GO:0042989)2.57497997
117protein localization to kinetochore (GO:0034501)2.56773581
118endodermal cell differentiation (GO:0035987)2.55899813
119positive regulation of fatty acid transport (GO:2000193)2.55358164
120somite development (GO:0061053)2.54148904
121regulation of cilium movement (GO:0003352)2.53348234
122synaptic transmission, cholinergic (GO:0007271)2.53086483
123IMP biosynthetic process (GO:0006188)2.52763103
124transmission of nerve impulse (GO:0019226)2.51765480
125protein K48-linked deubiquitination (GO:0071108)2.51674281
126regulation of gene silencing by RNA (GO:0060966)2.50750429
127regulation of posttranscriptional gene silencing (GO:0060147)2.50750429
128regulation of gene silencing by miRNA (GO:0060964)2.50750429
129wound healing, spreading of cells (GO:0044319)2.50106983
130somatic diversification of immunoglobulins (GO:0016445)2.49867799
131membrane repolarization during action potential (GO:0086011)2.49581475
132myeloid cell homeostasis (GO:0002262)2.48866064
133magnesium ion transport (GO:0015693)2.48413368
134B cell mediated immunity (GO:0019724)2.48351982
135DNA replication initiation (GO:0006270)2.48102935
136nuclear pore organization (GO:0006999)2.47827772
137regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.47061951
138replication fork processing (GO:0031297)2.45852751
139vitamin biosynthetic process (GO:0009110)2.43982449
140RNA destabilization (GO:0050779)2.43537978
141pyrimidine nucleobase catabolic process (GO:0006208)2.43331873
142ribosome assembly (GO:0042255)2.43159221
143cellular response to interferon-alpha (GO:0035457)2.42897210
144nuclear pore complex assembly (GO:0051292)2.42610139
145response to interferon-alpha (GO:0035455)2.42137697
146negative regulation of DNA-templated transcription, elongation (GO:0032785)2.41975601
147detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.41620459
148response to fluid shear stress (GO:0034405)2.40885597
149tooth mineralization (GO:0034505)2.40847058
150lymphocyte apoptotic process (GO:0070227)2.40220443
151basement membrane organization (GO:0071711)2.40157685
152morphogenesis of an endothelium (GO:0003159)2.39846111
153endothelial tube morphogenesis (GO:0061154)2.39846111
154protein heterotrimerization (GO:0070208)2.39437765
155translational elongation (GO:0006414)2.37964413
156electron transport chain (GO:0022900)2.37364841
157positive regulation of protein import into nucleus, translocation (GO:0033160)2.36778633
158membrane disassembly (GO:0030397)2.36679444
159nuclear envelope disassembly (GO:0051081)2.36679444
160transcription elongation from RNA polymerase III promoter (GO:0006385)2.36544322
161termination of RNA polymerase III transcription (GO:0006386)2.36544322
162heterochromatin organization (GO:0070828)2.34916342
163cellular biogenic amine biosynthetic process (GO:0042401)2.34821525
164tryptophan metabolic process (GO:0006568)2.34751143
165maturation of SSU-rRNA (GO:0030490)2.34659821
166positive regulation of T cell apoptotic process (GO:0070234)2.33752451
167regulation of spindle organization (GO:0090224)2.32864047
168respiratory electron transport chain (GO:0022904)2.32524663
169pyrimidine ribonucleoside catabolic process (GO:0046133)2.31770402
170detection of light stimulus involved in sensory perception (GO:0050962)2.31717605
171detection of light stimulus involved in visual perception (GO:0050908)2.31717605
172negative regulation of DNA-dependent DNA replication (GO:2000104)2.31596595
173regulation of mitotic spindle organization (GO:0060236)2.31431761
174nephron tubule morphogenesis (GO:0072078)2.31007890
175translational initiation (GO:0006413)2.28590450
176neuron projection extension involved in neuron projection guidance (GO:1902284)2.28040203
177axon extension involved in axon guidance (GO:0048846)2.28040203
178cellular response to fluid shear stress (GO:0071498)2.26673023
179glucocorticoid receptor signaling pathway (GO:0042921)2.26083059
180positive regulation of lymphocyte apoptotic process (GO:0070230)2.25255803
181positive regulation of endothelial cell apoptotic process (GO:2000353)2.25056742
182telomere maintenance via recombination (GO:0000722)2.23870575
183DNA replication-dependent nucleosome organization (GO:0034723)2.22879191
184DNA replication-dependent nucleosome assembly (GO:0006335)2.22879191
185positive regulation of interferon-beta production (GO:0032728)2.21292013
186regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.19770491
187regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.19544564
188leukocyte apoptotic process (GO:0071887)2.18972497
189IMP metabolic process (GO:0046040)2.18582932
190response to peptidoglycan (GO:0032494)2.18509475
191skin morphogenesis (GO:0043589)2.16421165
192regulation of integrin activation (GO:0033623)2.16068092
193collagen fibril organization (GO:0030199)2.14420602
194hyaluronan catabolic process (GO:0030214)2.13845702
195chondrocyte proliferation (GO:0035988)2.12722463
196metanephric mesenchyme development (GO:0072075)2.11941739
197regulation of B cell receptor signaling pathway (GO:0050855)2.11030324
198nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.10945381
199mitotic recombination (GO:0006312)2.10600392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.44486048
2EZH2_22144423_ChIP-Seq_EOC_Human4.33755459
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.80912598
4ZNF274_21170338_ChIP-Seq_K562_Hela3.53602193
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.28452145
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.22926673
7VDR_22108803_ChIP-Seq_LS180_Human3.13672707
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.88863889
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.71536060
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.56031965
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48642683
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48156019
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.47952015
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44421329
15IRF1_19129219_ChIP-ChIP_H3396_Human2.41601868
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.40590945
17* MYC_22102868_ChIP-Seq_BL_Human2.21244071
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17966091
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.17729044
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.10976611
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08948357
22GBX2_23144817_ChIP-Seq_PC3_Human2.08228834
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07870760
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04219682
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94893543
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.91522562
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90987774
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.87203859
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86735711
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83914715
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83378335
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81858480
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.81728170
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80350184
35VDR_21846776_ChIP-Seq_THP-1_Human1.77923918
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75767356
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74907004
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.74821607
39EWS_26573619_Chip-Seq_HEK293_Human1.74215366
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73124350
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71930720
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71580730
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71330192
44TAF15_26573619_Chip-Seq_HEK293_Human1.70765893
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70010870
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67257580
47P300_19829295_ChIP-Seq_ESCs_Human1.66946905
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66204304
49FUS_26573619_Chip-Seq_HEK293_Human1.65480443
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60049557
51MYC_18940864_ChIP-ChIP_HL60_Human1.58871527
52* IRF8_27001747_Chip-Seq_BMDM_Mouse1.55607704
53AR_21909140_ChIP-Seq_LNCAP_Human1.55466755
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54904019
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53404000
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51934563
57RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51555844
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49857971
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48703754
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47800253
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.47742144
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47655497
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47505561
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45387510
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44721860
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43997232
67XRN2_22483619_ChIP-Seq_HELA_Human1.43047928
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.42393944
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42299126
70* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41347912
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40745687
72TFEB_21752829_ChIP-Seq_HELA_Human1.40417966
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40296846
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40214973
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38581122
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37720690
77REST_21632747_ChIP-Seq_MESCs_Mouse1.36754220
78SPI1_23547873_ChIP-Seq_NB4_Human1.36616315
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36589809
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36589809
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35690929
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.34604015
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34533899
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34483814
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34323011
86RNF2_27304074_Chip-Seq_NSC_Mouse1.33835994
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32628071
88BCAT_22108803_ChIP-Seq_LS180_Human1.32547741
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32443870
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32034283
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31853361
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31029843
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30917670
94MAF_26560356_Chip-Seq_TH1_Human1.30734085
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29682250
96CBP_20019798_ChIP-Seq_JUKART_Human1.28368834
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28368834
98CLOCK_20551151_ChIP-Seq_293T_Human1.27663481
99VDR_24763502_ChIP-Seq_THP-1_Human1.27411298
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27130455
101SOX2_19829295_ChIP-Seq_ESCs_Human1.26880068
102NANOG_19829295_ChIP-Seq_ESCs_Human1.26880068
103FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26675382
104E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25784885
105SRF_21415370_ChIP-Seq_HL-1_Mouse1.24884920
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24672026
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24583924
108TCF7_22412390_ChIP-Seq_EML_Mouse1.24557389
109KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24506064
110KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24506064
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24506064
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23755316
113TP53_22573176_ChIP-Seq_HFKS_Human1.23586275
114GATA3_21878914_ChIP-Seq_MCF-7_Human1.23220333
115FOXA1_25329375_ChIP-Seq_VCAP_Human1.20708185
116FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20708185
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20671157
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20461959
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.20094116
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20050136
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19515079
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19210109
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19103217
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18812678
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18409894
126AR_25329375_ChIP-Seq_VCAP_Human1.18024849
127* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17927914
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16948688
129DCP1A_22483619_ChIP-Seq_HELA_Human1.16940968
130JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16634484
131JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16464384
132NCOR_22424771_ChIP-Seq_293T_Human1.16385961
133IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16361114
134UTX_26944678_Chip-Seq_JUKART_Human1.16080458
135TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16068527
136EST1_17652178_ChIP-ChIP_JURKAT_Human1.15316836
137ATF3_27146783_Chip-Seq_COLON_Human1.15214361
138ETS1_20019798_ChIP-Seq_JURKAT_Human1.14745543
139RUNX1_22412390_ChIP-Seq_EML_Mouse1.14599894
140TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13272103
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12559294
142ER_23166858_ChIP-Seq_MCF-7_Human1.12088007
143SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11750583
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11485896
145SMAD3_21741376_ChIP-Seq_EPCs_Human1.11030249
146TP63_19390658_ChIP-ChIP_HaCaT_Human1.08697650
147KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08575073
148KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08517142
149MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08404046
150AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08391400
151SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08193459
152ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07890020
153HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07306526
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07173104
155NFE2_27457419_Chip-Seq_LIVER_Mouse1.06623756
156GABP_17652178_ChIP-ChIP_JURKAT_Human1.06568693
157CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06170569
158KDM2B_26808549_Chip-Seq_DND41_Human1.05831822
159BP1_19119308_ChIP-ChIP_Hs578T_Human1.04638882
160CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03773509
161VDR_23849224_ChIP-Seq_CD4+_Human1.03500277
162TAF2_19829295_ChIP-Seq_ESCs_Human1.02941597
163SMAD4_21799915_ChIP-Seq_A2780_Human1.02933085
164NANOG_20526341_ChIP-Seq_ESCs_Human1.02596694
165ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02514850
166STAT3_23295773_ChIP-Seq_U87_Human1.02428124
167EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02041032
168SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01932426
169STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01757572
170IGF1R_20145208_ChIP-Seq_DFB_Human1.01666809
171POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01452409
172FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00903345
173EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00884387
174* HOXB7_26014856_ChIP-Seq_BT474_Human1.00498441
175NCOR1_26117541_ChIP-Seq_K562_Human1.00387625
176* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00164543
177RACK7_27058665_Chip-Seq_MCF-7_Human1.00149910
178MYC_19829295_ChIP-Seq_ESCs_Human1.00000104
179MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99867100
180GABP_19822575_ChIP-Seq_HepG2_Human0.99440779
181SMAD4_21741376_ChIP-Seq_EPCs_Human0.98962599
182PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98893638
183TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98299444
184MYB_26560356_Chip-Seq_TH2_Human0.97888607
185TCF4_22108803_ChIP-Seq_LS180_Human0.97771452
186PIAS1_25552417_ChIP-Seq_VCAP_Human0.97416485
187* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96939818
188EZH2_27294783_Chip-Seq_NPCs_Mouse0.95145020
189MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94981294
190JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94913839
191E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94838752
192NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94597479

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.52925785
2MP0003646_muscle_fatigue4.12687721
3MP0008438_abnormal_cutaneous_collagen4.10882535
4MP0003705_abnormal_hypodermis_morpholog3.40474044
5MP0003136_yellow_coat_color2.69543590
6MP0002736_abnormal_nociception_after2.58925738
7MP0003195_calcinosis2.54188771
8MP0001968_abnormal_touch/_nociception2.43193215
9MP0000569_abnormal_digit_pigmentation2.42017180
10MP0002938_white_spotting2.35669233
11MP0003303_peritoneal_inflammation2.35441365
12MP0003011_delayed_dark_adaptation2.32134666
13MP0006292_abnormal_olfactory_placode2.25240790
14MP0005275_abnormal_skin_tensile2.22565984
15MP0003566_abnormal_cell_adhesion2.21355532
16MP0001485_abnormal_pinna_reflex2.20451863
17MP0010352_gastrointestinal_tract_polyps2.18769389
18MP0009278_abnormal_bone_marrow2.18573910
19MP0003279_aneurysm2.09736314
20MP0002653_abnormal_ependyma_morphology2.09657930
21MP0005023_abnormal_wound_healing2.06504706
22MP0006072_abnormal_retinal_apoptosis2.06133135
23MP0004133_heterotaxia2.05991475
24MP0001958_emphysema2.00702779
25MP0005257_abnormal_intraocular_pressure1.99571712
26MP0002102_abnormal_ear_morphology1.92212271
27MP0005503_abnormal_tendon_morphology1.87314954
28MP0002735_abnormal_chemical_nociception1.87174853
29MP0010030_abnormal_orbit_morphology1.84838653
30MP0005551_abnormal_eye_electrophysiolog1.82595950
31MP0005174_abnormal_tail_pigmentation1.81396254
32MP0003693_abnormal_embryo_hatching1.81021450
33MP0009840_abnormal_foam_cell1.80490857
34MP0003122_maternal_imprinting1.76320187
35MP0003436_decreased_susceptibility_to1.75190801
36MP0010307_abnormal_tumor_latency1.74684890
37MP0002277_abnormal_respiratory_mucosa1.74062390
38MP0001835_abnormal_antigen_presentation1.70017056
39MP0004885_abnormal_endolymph1.66043144
40MP0009745_abnormal_behavioral_response1.63714120
41MP0009046_muscle_twitch1.62534056
42MP0008877_abnormal_DNA_methylation1.60744951
43MP0005058_abnormal_lysosome_morphology1.59389879
44MP0000372_irregular_coat_pigmentation1.58956355
45MP0001905_abnormal_dopamine_level1.58844801
46MP0005076_abnormal_cell_differentiation1.56034293
47MP0004142_abnormal_muscle_tone1.54974924
48MP0000685_abnormal_immune_system1.54738786
49MP0004957_abnormal_blastocyst_morpholog1.51877627
50MP0003077_abnormal_cell_cycle1.51675313
51MP0008775_abnormal_heart_ventricle1.51304584
52MP0000049_abnormal_middle_ear1.51243046
53MP0000858_altered_metastatic_potential1.50669501
54MP0005397_hematopoietic_system_phenotyp1.50423363
55MP0001545_abnormal_hematopoietic_system1.50423363
56MP0003448_altered_tumor_morphology1.49890486
57MP0005253_abnormal_eye_physiology1.48653451
58MP0004808_abnormal_hematopoietic_stem1.47442992
59MP0006082_CNS_inflammation1.44898651
60MP0003111_abnormal_nucleus_morphology1.44252186
61MP0010094_abnormal_chromosome_stability1.42346803
62MP0003300_gastrointestinal_ulcer1.41720507
63MP0003890_abnormal_embryonic-extraembry1.41427136
64MP0005671_abnormal_response_to1.40330190
65MP0001440_abnormal_grooming_behavior1.39893335
66MP0006054_spinal_hemorrhage1.38586851
67MP0010386_abnormal_urinary_bladder1.38206019
68MP0000733_abnormal_muscle_development1.37455657
69MP0005646_abnormal_pituitary_gland1.36071652
70MP0008007_abnormal_cellular_replicative1.35167098
71MP0003123_paternal_imprinting1.34657022
72MP0002163_abnormal_gland_morphology1.34612744
73MP0008875_abnormal_xenobiotic_pharmacok1.34417281
74MP0002452_abnormal_antigen_presenting1.34020401
75MP0005645_abnormal_hypothalamus_physiol1.33307892
76MP0001790_abnormal_immune_system1.33232004
77MP0005387_immune_system_phenotype1.33232004
78MP0008872_abnormal_physiological_respon1.31375415
79MP0001986_abnormal_taste_sensitivity1.30325777
80MP0001533_abnormal_skeleton_physiology1.29141156
81MP0003283_abnormal_digestive_organ1.28440269
82MP0002419_abnormal_innate_immunity1.26476552
83MP0001529_abnormal_vocalization1.26096337
84MP0001800_abnormal_humoral_immune1.25747162
85MP0009764_decreased_sensitivity_to1.25173922
86MP0002933_joint_inflammation1.24833561
87MP0002876_abnormal_thyroid_physiology1.24002509
88MP0008995_early_reproductive_senescence1.23748590
89* MP0002272_abnormal_nervous_system1.23440130
90MP0002396_abnormal_hematopoietic_system1.23007377
91MP0004510_myositis1.20950080
92MP0000343_altered_response_to1.19298713
93MP0003091_abnormal_cell_migration1.18403833
94MP0009333_abnormal_splenocyte_physiolog1.18394720
95MP0001970_abnormal_pain_threshold1.18280349
96MP0002095_abnormal_skin_pigmentation1.18136387
97MP0002405_respiratory_system_inflammati1.17596956
98MP0000350_abnormal_cell_proliferation1.17236056
99MP0008789_abnormal_olfactory_epithelium1.17030228
100MP0002928_abnormal_bile_duct1.16968129
101* MP0000026_abnormal_inner_ear1.16194217
102MP0005084_abnormal_gallbladder_morpholo1.16159857
103MP0000631_abnormal_neuroendocrine_gland1.15501764
104MP0004272_abnormal_basement_membrane1.15457526
105MP0005410_abnormal_fertilization1.14849432
106MP0003880_abnormal_central_pattern1.14541734
107MP0002733_abnormal_thermal_nociception1.14211135
108MP0002572_abnormal_emotion/affect_behav1.13923431
109* MP0002557_abnormal_social/conspecific_i1.11716160
110MP0002638_abnormal_pupillary_reflex1.11689472
111MP0000490_abnormal_crypts_of1.11651718
112MP0005000_abnormal_immune_tolerance1.11591935
113MP0000230_abnormal_systemic_arterial1.11125010
114MP0003121_genomic_imprinting1.10895608
115MP0009379_abnormal_foot_pigmentation1.10233883
116MP0003191_abnormal_cellular_cholesterol1.08554492
117MP0009785_altered_susceptibility_to1.07884345
118MP0005025_abnormal_response_to1.07015737
119MP0000767_abnormal_smooth_muscle1.06021014
120MP0000689_abnormal_spleen_morphology1.05014845
121MP0005390_skeleton_phenotype1.05005606
122MP0009053_abnormal_anal_canal1.03796749
123MP0002723_abnormal_immune_serum1.03465475
124MP0005389_reproductive_system_phenotype1.03359719
125MP0002138_abnormal_hepatobiliary_system1.03129738
126MP0003938_abnormal_ear_development1.02729838
127MP0001324_abnormal_eye_pigmentation1.02584706
128MP0004947_skin_inflammation1.02117710
129MP0005195_abnormal_posterior_eye1.01391416
130MP0004197_abnormal_fetal_growth/weight/1.01383320
131MP0000538_abnormal_urinary_bladder1.01250304
132MP0001730_embryonic_growth_arrest1.01214108
133MP0001819_abnormal_immune_cell0.99027038
134MP0005508_abnormal_skeleton_morphology0.98983571
135MP0002420_abnormal_adaptive_immunity0.98935297
136MP0002086_abnormal_extraembryonic_tissu0.98380603
137MP0008932_abnormal_embryonic_tissue0.98236135
138MP0002398_abnormal_bone_marrow0.98196535
139MP0002148_abnormal_hypersensitivity_rea0.97627866
140MP0001915_intracranial_hemorrhage0.97299240
141MP0003172_abnormal_lysosome_physiology0.95234187
142MP0005379_endocrine/exocrine_gland_phen0.95208221
143MP0002751_abnormal_autonomic_nervous0.94647535
144MP0001984_abnormal_olfaction0.94546611
145MP0002160_abnormal_reproductive_system0.94330243
146MP0002019_abnormal_tumor_incidence0.94205545
147MP0006276_abnormal_autonomic_nervous0.94160835
148MP0002722_abnormal_immune_system0.93974508
149MP0005386_behavior/neurological_phenoty0.93900864
150MP0004924_abnormal_behavior0.93900864
151MP0001243_abnormal_dermal_layer0.92142064
152MP0001293_anophthalmia0.92001633
153MP0004130_abnormal_muscle_cell0.89415349
154* MP0002064_seizures0.89078176
155* MP0001963_abnormal_hearing_physiology0.88006023
156MP0000716_abnormal_immune_system0.87781646
157MP0003137_abnormal_impulse_conducting0.87762056
158MP0010368_abnormal_lymphatic_system0.87554732
159* MP0002067_abnormal_sensory_capabilities0.87339168
160MP0000465_gastrointestinal_hemorrhage0.86445083
161MP0002429_abnormal_blood_cell0.86215297
162MP0000778_abnormal_nervous_system0.86166591
163MP0002088_abnormal_embryonic_growth/wei0.85473257
164MP0002998_abnormal_bone_remodeling0.84716689
165MP0000750_abnormal_muscle_regeneration0.84670092
166MP0003984_embryonic_growth_retardation0.84354302
167MP0001175_abnormal_lung_morphology0.84180489
168MP0001672_abnormal_embryogenesis/_devel0.83798300
169MP0005380_embryogenesis_phenotype0.83798300
170MP0002060_abnormal_skin_morphology0.83712071
171MP0003567_abnormal_fetal_cardiomyocyte0.83176567
172MP0001853_heart_inflammation0.82383771
173MP0001845_abnormal_inflammatory_respons0.81888054
174MP0003115_abnormal_respiratory_system0.81691147
175MP0001697_abnormal_embryo_size0.81615039
176MP0004215_abnormal_myocardial_fiber0.80606331
177MP0005332_abnormal_amino_acid0.80478891
178* MP0002080_prenatal_lethality0.80144303
179* MP0001486_abnormal_startle_reflex0.79916723
180MP0003937_abnormal_limbs/digits/tail_de0.79715216
181* MP0002752_abnormal_somatic_nervous0.79491017
182MP0001501_abnormal_sleep_pattern0.79295113
183MP0005464_abnormal_platelet_physiology0.77401352
184MP0000015_abnormal_ear_pigmentation0.76725403
185MP0009384_cardiac_valve_regurgitation0.76371053
186MP0000428_abnormal_craniofacial_morphol0.76197818
187MP0002090_abnormal_vision0.75597101
188MP0002877_abnormal_melanocyte_morpholog0.74498701
189* MP0004742_abnormal_vestibular_system0.74320083
190MP0004145_abnormal_muscle_electrophysio0.74148264
191MP0003795_abnormal_bone_structure0.73863395
192MP0003878_abnormal_ear_physiology0.73745884
193MP0005377_hearing/vestibular/ear_phenot0.73745884
194MP0005670_abnormal_white_adipose0.73583308
195MP0001919_abnormal_reproductive_system0.72245105

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.55894713
2Premature rupture of membranes (HP:0001788)4.90614714
3Cutaneous melanoma (HP:0012056)4.50767012
4Pancreatic cysts (HP:0001737)3.82535680
5Molar tooth sign on MRI (HP:0002419)3.80374204
6Abnormality of midbrain morphology (HP:0002418)3.80374204
7Ankle contracture (HP:0006466)3.56626561
8True hermaphroditism (HP:0010459)3.51789203
9Pancreatic fibrosis (HP:0100732)3.43830741
10Congenital, generalized hypertrichosis (HP:0004540)3.39084474
11Nephronophthisis (HP:0000090)3.37555735
12Cerebral aneurysm (HP:0004944)3.33730820
13Shallow orbits (HP:0000586)3.25510808
14Type II lissencephaly (HP:0007260)3.22327407
15Selective tooth agenesis (HP:0001592)3.16205292
16Congenital stationary night blindness (HP:0007642)3.10796504
17Peritonitis (HP:0002586)3.10494009
18Cervical subluxation (HP:0003308)3.06288483
19Vertebral compression fractures (HP:0002953)3.06276015
20Aortic dissection (HP:0002647)3.05087099
21Aortic aneurysm (HP:0004942)2.97874583
22Abolished electroretinogram (ERG) (HP:0000550)2.97845664
23Increased cerebral lipofuscin (HP:0011813)2.89551018
24Methylmalonic aciduria (HP:0012120)2.89069309
25Hyperglycinemia (HP:0002154)2.82878533
26Abnormality of the renal medulla (HP:0100957)2.80531740
27Decreased electroretinogram (ERG) amplitude (HP:0000654)2.79940955
28Acute necrotizing encephalopathy (HP:0006965)2.79719120
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.78311014
30Osteolytic defects of the hand bones (HP:0009699)2.78311014
31Methylmalonic acidemia (HP:0002912)2.74305486
32Soft skin (HP:0000977)2.70408645
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.69365365
34Meningioma (HP:0002858)2.67561213
35Concave nail (HP:0001598)2.65448183
36Eczematoid dermatitis (HP:0000976)2.63394951
37Mitochondrial inheritance (HP:0001427)2.62871103
38Short tibia (HP:0005736)2.62760585
39Genu recurvatum (HP:0002816)2.62110959
40Dilatation of the ascending aorta (HP:0005111)2.60742829
413-Methylglutaconic aciduria (HP:0003535)2.57890424
42Decreased circulating renin level (HP:0003351)2.53618331
43Blue sclerae (HP:0000592)2.48854967
44Acute encephalopathy (HP:0006846)2.48441729
45Progressive macrocephaly (HP:0004481)2.48012313
46Pendular nystagmus (HP:0012043)2.47392991
47Biconcave vertebral bodies (HP:0004586)2.47002534
48Clumsiness (HP:0002312)2.46588825
49Vacuolated lymphocytes (HP:0001922)2.44606233
50Chronic hepatic failure (HP:0100626)2.43592545
51Aplasia/hypoplasia of the uterus (HP:0008684)2.43056364
52Cellulitis (HP:0100658)2.43044168
53Bladder diverticulum (HP:0000015)2.42406219
54Interstitial pulmonary disease (HP:0006530)2.39117074
55Inability to walk (HP:0002540)2.38770570
56Increased CSF lactate (HP:0002490)2.37821767
57Increased density of long bones (HP:0006392)2.36688783
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.35286776
59Tubular atrophy (HP:0000092)2.33781336
60Short femoral neck (HP:0100864)2.30105073
61Recurrent abscess formation (HP:0002722)2.29491577
62Atrophic scars (HP:0001075)2.28704793
63Abnormal mitochondria in muscle tissue (HP:0008316)2.28523166
64Abnormal number of erythroid precursors (HP:0012131)2.28268237
65Congenital sensorineural hearing impairment (HP:0008527)2.28068339
66Optic disc pallor (HP:0000543)2.26789953
67Sclerocornea (HP:0000647)2.26681704
68Hypoplasia of the uterus (HP:0000013)2.26270238
69Medial flaring of the eyebrow (HP:0010747)2.25993910
70Anencephaly (HP:0002323)2.25949762
71Ulnar bowing (HP:0003031)2.23873212
72Keratoconus (HP:0000563)2.23186824
73Increased corneal curvature (HP:0100692)2.23186824
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22274593
75Abnormality of alanine metabolism (HP:0010916)2.22274593
76Hyperalaninemia (HP:0003348)2.22274593
77Abnormality of the renal cortex (HP:0011035)2.22258446
78Cystic liver disease (HP:0006706)2.20282252
79Mitral valve prolapse (HP:0001634)2.19577348
80Abnormality of the peritoneum (HP:0002585)2.19198263
81Agnosia (HP:0010524)2.17809624
82Abnormality of the acetabulum (HP:0003170)2.16087319
83Spinal rigidity (HP:0003306)2.15464154
84Abnormality of the phalanges of the 2nd finger (HP:0009541)2.15127186
85Abnormality of the renal collecting system (HP:0004742)2.14139359
86Hypoplasia of the pons (HP:0012110)2.11787489
87Myocardial infarction (HP:0001658)2.08756952
88High pitched voice (HP:0001620)2.08549578
89Thrombocytosis (HP:0001894)2.08359569
90Abnormal drinking behavior (HP:0030082)2.07313592
91Polydipsia (HP:0001959)2.07313592
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.07046760
93Wormian bones (HP:0002645)2.06944437
94Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06407213
95Short 4th metacarpal (HP:0010044)2.06407213
96Increased connective tissue (HP:0009025)2.06276636
97IgG deficiency (HP:0004315)2.05908237
98Hematochezia (HP:0002573)2.05352754
99Abnormality of the pons (HP:0007361)2.03398880
100Hepatocellular necrosis (HP:0001404)2.03288784
101Absent thumb (HP:0009777)2.03163280
102Patellar aplasia (HP:0006443)2.02596911
103Emphysema (HP:0002097)2.00584073
104Cerebral palsy (HP:0100021)2.00007854
105Metabolic alkalosis (HP:0200114)1.99894069
106Adactyly (HP:0009776)1.99752182
107Abnormality of the vertebral endplates (HP:0005106)1.97912731
108Aplasia/Hypoplasia of the patella (HP:0006498)1.97838828
109Irregular vertebral endplates (HP:0003301)1.97786547
110Abnormality of the distal phalanges of the toes (HP:0010182)1.97426942
111Slender long bone (HP:0003100)1.97310496
112Abnormality of cells of the erythroid lineage (HP:0012130)1.96697803
113Wrist flexion contracture (HP:0001239)1.95963848
114Attenuation of retinal blood vessels (HP:0007843)1.95439538
115Elevated erythrocyte sedimentation rate (HP:0003565)1.94146581
116Increased hepatocellular lipid droplets (HP:0006565)1.92153228
117Cerebellar dysplasia (HP:0007033)1.92144811
118Optic nerve hypoplasia (HP:0000609)1.91791650
119Poor head control (HP:0002421)1.91659888
120Systemic lupus erythematosus (HP:0002725)1.91627821
121Abnormality of the vasculature of the conjunctiva (HP:0008054)1.91065099
122Camptodactyly of toe (HP:0001836)1.90618872
123Progressive cerebellar ataxia (HP:0002073)1.90465917
124Lipid accumulation in hepatocytes (HP:0006561)1.90406765
125Septo-optic dysplasia (HP:0100842)1.90167212
126Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.89503847
127Generalized amyotrophy (HP:0003700)1.88677032
128Congenital hepatic fibrosis (HP:0002612)1.87976714
129Breech presentation (HP:0001623)1.87318768
130Agitation (HP:0000713)1.87012044
131Reticulocytopenia (HP:0001896)1.87007091
132Mucopolysacchariduria (HP:0008155)1.86421555
133Urinary glycosaminoglycan excretion (HP:0003541)1.86421555
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86237330
135Abnormality of macrophages (HP:0004311)1.86026346
136Progressive inability to walk (HP:0002505)1.85712080
137Furrowed tongue (HP:0000221)1.85000603
138Small hand (HP:0200055)1.84411788
139Hepatic necrosis (HP:0002605)1.84110471
140Abnormal respiratory epithelium morphology (HP:0012253)1.83431355
141Abnormal respiratory motile cilium morphology (HP:0005938)1.83431355
142Hypoplasia of the ulna (HP:0003022)1.83282756
143Fragile skin (HP:0001030)1.83261595
144Trismus (HP:0000211)1.83119704
145Retinal dysplasia (HP:0007973)1.83020533
146Short palpebral fissure (HP:0012745)1.81816019
147Recurrent bacterial skin infections (HP:0005406)1.81715088
148Autoimmune thrombocytopenia (HP:0001973)1.81434411
149Broad metatarsal (HP:0001783)1.81350798
150Decreased central vision (HP:0007663)1.81341898
151Lissencephaly (HP:0001339)1.81092406
152Abnormal rod and cone electroretinograms (HP:0008323)1.80217012
153Bowel diverticulosis (HP:0005222)1.80006370
154Spinal cord lesions (HP:0100561)1.79104481
155Syringomyelia (HP:0003396)1.79104481
156Mediastinal lymphadenopathy (HP:0100721)1.78275503
157Renal Fanconi syndrome (HP:0001994)1.77670008
158Persistence of primary teeth (HP:0006335)1.76888097
159Mesomelia (HP:0003027)1.76072457
160Polyuria (HP:0000103)1.76030954
161Aneurysm (HP:0002617)1.75488430
162Mesangial abnormality (HP:0001966)1.75385371
163Male pseudohermaphroditism (HP:0000037)1.75342952
164Slender build (HP:0001533)1.75097278
165Bilateral microphthalmos (HP:0007633)1.74611722
166Dysostosis multiplex (HP:0000943)1.74125401
167Large for gestational age (HP:0001520)1.72688941
168Dynein arm defect of respiratory motile cilia (HP:0012255)1.71929934
169Absent/shortened dynein arms (HP:0200106)1.71929934
170Chorioretinal atrophy (HP:0000533)1.68820203
171Conjunctival telangiectasia (HP:0000524)1.68753842
172Bicuspid aortic valve (HP:0001647)1.68599993
173Recurrent lower respiratory tract infections (HP:0002783)1.67616274
174Elbow flexion contracture (HP:0002987)1.67067741
175Abnormal delivery (HP:0001787)1.65235318
176Spondylolisthesis (HP:0003302)1.65211500
177Osteomyelitis (HP:0002754)1.64798494
178Long eyelashes (HP:0000527)1.64120164
179Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.63667206
180Deviation of the hallux (HP:0010051)1.62774174
181Disinhibition (HP:0000734)1.62003463
182Blepharitis (HP:0000498)1.61633531
183Radial bowing (HP:0002986)1.60912436
184Abnormality of mucopolysaccharide metabolism (HP:0011020)1.60727124
185Abnormality of polysaccharide metabolism (HP:0011012)1.60727124
186Abnormality of glycosaminoglycan metabolism (HP:0004371)1.60727124
187Hallux valgus (HP:0001822)1.60182419
188Mitral regurgitation (HP:0001653)1.60034671
189Joint stiffness (HP:0001387)1.59816219
190Flexion contracture of toe (HP:0005830)1.59128308
191Joint contractures involving the joints of the feet (HP:0100492)1.59128308
192Recurrent gram-negative bacterial infections (HP:0005420)1.57316367
193Abnormality of the calcaneus (HP:0008364)1.55109510
194Bowing of the arm (HP:0006488)1.54797407
195Bowed forearm bones (HP:0003956)1.54797407
196Renal duplication (HP:0000075)1.54115737
197Vascular tortuosity (HP:0004948)1.52329412
198Axonal loss (HP:0003447)1.52258838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.97581910
2ADRBK23.81293114
3TAOK33.68291689
4TRIB33.21983446
5ACVR1B3.12022509
6PKN23.05483814
7ERN12.99761366
8NME22.65600151
9ZAK2.47410745
10WNK32.45547706
11BMPR1B2.34683650
12GRK12.32931647
13KIT2.26198506
14RPS6KA42.24125395
15TTN2.18080022
16BUB12.10695688
17MAP4K22.03014354
18NUAK12.02082596
19TBK11.94928108
20BLK1.88481660
21LRRK21.88218975
22WNK41.82340654
23STK101.78688507
24MAP4K11.69413074
25WEE11.68380556
26PAK41.67507785
27PIM21.63966972
28NEK21.62951123
29DYRK21.58725726
30EPHA21.55652305
31MAP2K31.54826663
32INSRR1.54663874
33DDR21.54423673
34TESK21.53334383
35MAP3K101.53081862
36VRK21.52920318
37TXK1.51982769
38TYK21.47960125
39BMX1.45475060
40PTK61.45302390
41CASK1.43825185
42MAPK151.42192727
43CDC71.40566332
44EPHA31.40514751
45RPS6KB21.39672004
46BCKDK1.37399691
47TGFBR21.36769334
48BRD41.36448904
49PINK11.35644094
50MAP3K81.35130968
51MAPK131.34268190
52STK31.34241083
53SCYL21.32718790
54GRK71.32157797
55MKNK21.31945342
56VRK11.29660026
57ADRBK11.26998499
58TESK11.26270458
59TNIK1.24620242
60MAP3K31.24533283
61PDGFRA1.20757324
62CDK121.17508177
63PAK21.16088195
64STK161.15003277
65FGFR21.13579052
66PRKCG1.10133206
67DYRK31.07751730
68CAMKK21.07146831
69FLT31.06798603
70ZAP701.05064342
71CSF1R1.04646455
72TAF11.03759535
73CDK41.02717978
74TTK1.01620342
75DAPK21.01119876
76EIF2AK11.00621941
77LATS21.00336951
78TRIM280.99823677
79JAK30.99430849
80FGFR40.97982741
81NEK90.97617202
82TIE10.96990182
83EEF2K0.96565503
84STK390.95486835
85CDK60.95153866
86ALK0.94817512
87CDK70.94721061
88PIM10.93840678
89KDR0.92680388
90TGFBR10.91253016
91PAK30.90943278
92IKBKB0.90223654
93OXSR10.89502949
94MAP3K110.88009325
95RIPK10.86790006
96PNCK0.86125919
97MATK0.86033443
98CAMK1D0.85753911
99SIK20.81383653
100CSK0.80732280
101PLK10.78065623
102EPHB10.77786303
103STK40.76473891
104MAP3K40.75785165
105AURKB0.75122282
106MARK10.74943599
107BTK0.74349136
108TLK10.73887786
109MKNK10.72165102
110PRKCE0.72098921
111PAK10.71531512
112PLK30.70763033
113PRKCH0.70613289
114MTOR0.68133883
115MAP2K70.67919306
116ATR0.67228218
117PRKCQ0.65769579
118CSNK1G20.65481115
119PLK20.65099115
120BRSK20.63737807
121PKN10.63692696
122MOS0.62131971
123HCK0.61694348
124ILK0.60139343
125CHUK0.60076734
126JAK10.59407932
127TSSK60.57460313
128NEK10.57371798
129CSNK1G30.57098184
130CSNK1G10.56875288
131MARK30.56236958
132PRKCI0.54109576
133MAPKAPK50.53364930
134RPS6KA60.53330430
135IRAK40.53147188
136PRKACA0.51766904
137CSNK1A10.50286899
138EIF2AK30.49894444
139SIK10.49663845
140IKBKE0.49236877
141PRKD20.48115513
142LYN0.47245842
143SGK20.47020503
144PASK0.46832091
145TAOK20.46411087
146MAPKAPK20.46389323
147RET0.45916723
148PIK3CA0.45241676
149LATS10.45030867
150NTRK20.44223638
151SGK2230.44159806
152SGK4940.44159806
153EPHB20.43805773
154GRK50.43511908
155RPS6KA50.43192510
156CAMK10.42805554
157NME10.42527891
158IRAK30.41943911
159TYRO30.41756812
160BCR0.41524647
161CSNK1A1L0.40552686
162PRKCZ0.39982126
163SYK0.39545299
164CAMK2A0.39084031
165PLK40.39002928
166EGFR0.37844420
167PDK20.37821753
168MAPK40.37539432
169FGFR30.37413929
170ABL20.37070835
171GSK3A0.36786541
172MUSK0.36496412
173CHEK20.35930318
174MAP2K20.34183818
175NTRK30.33764554
176MAP3K140.33305600
177PTK2B0.32891593

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.44074929
2DNA replication_Homo sapiens_hsa030303.00161705
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.67083395
4Parkinsons disease_Homo sapiens_hsa050122.64873992
5Mismatch repair_Homo sapiens_hsa034302.43058942
6Protein export_Homo sapiens_hsa030602.28275330
7Phototransduction_Homo sapiens_hsa047442.25109367
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.18577313
9Sulfur metabolism_Homo sapiens_hsa009202.04521911
10Base excision repair_Homo sapiens_hsa034102.01495452
11Tryptophan metabolism_Homo sapiens_hsa003801.96907220
12One carbon pool by folate_Homo sapiens_hsa006701.94815542
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.93902365
14Linoleic acid metabolism_Homo sapiens_hsa005911.86376211
15Ribosome_Homo sapiens_hsa030101.82871266
16Huntingtons disease_Homo sapiens_hsa050161.80475355
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79177718
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78624909
19Alzheimers disease_Homo sapiens_hsa050101.77000551
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72824568
21Cell cycle_Homo sapiens_hsa041101.70890415
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70683165
23Leishmaniasis_Homo sapiens_hsa051401.69704072
24p53 signaling pathway_Homo sapiens_hsa041151.69070062
25Selenocompound metabolism_Homo sapiens_hsa004501.66762636
26Antigen processing and presentation_Homo sapiens_hsa046121.65504023
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.61061706
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59625305
29* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58907056
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56323411
31RNA transport_Homo sapiens_hsa030131.55812656
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55612136
33Cardiac muscle contraction_Homo sapiens_hsa042601.55551401
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48879668
35Staphylococcus aureus infection_Homo sapiens_hsa051501.48618979
36Malaria_Homo sapiens_hsa051441.48379843
37Apoptosis_Homo sapiens_hsa042101.47215765
38Nitrogen metabolism_Homo sapiens_hsa009101.46285378
39Nicotine addiction_Homo sapiens_hsa050331.45418144
40Lysosome_Homo sapiens_hsa041421.44159341
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44015051
42Proteasome_Homo sapiens_hsa030501.43881893
43Legionellosis_Homo sapiens_hsa051341.41397756
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40426514
45Shigellosis_Homo sapiens_hsa051311.40424594
46Small cell lung cancer_Homo sapiens_hsa052221.39447506
47Spliceosome_Homo sapiens_hsa030401.38603418
48Fanconi anemia pathway_Homo sapiens_hsa034601.37269338
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.35511706
50Nucleotide excision repair_Homo sapiens_hsa034201.32995289
51Butanoate metabolism_Homo sapiens_hsa006501.32689832
52Ether lipid metabolism_Homo sapiens_hsa005651.32295046
53Osteoclast differentiation_Homo sapiens_hsa043801.29512504
54Herpes simplex infection_Homo sapiens_hsa051681.29411442
55Basal transcription factors_Homo sapiens_hsa030221.28140765
56Collecting duct acid secretion_Homo sapiens_hsa049661.27455375
57Chronic myeloid leukemia_Homo sapiens_hsa052201.24613508
58B cell receptor signaling pathway_Homo sapiens_hsa046621.24405715
59Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24161488
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23863328
61Pertussis_Homo sapiens_hsa051331.23462882
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22350731
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22291386
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22071502
65Caffeine metabolism_Homo sapiens_hsa002321.22062313
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21790595
67Proteoglycans in cancer_Homo sapiens_hsa052051.20466914
68Rheumatoid arthritis_Homo sapiens_hsa053231.20168749
69Toxoplasmosis_Homo sapiens_hsa051451.20127458
70MicroRNAs in cancer_Homo sapiens_hsa052061.19498727
71Hepatitis B_Homo sapiens_hsa051611.18287653
72Primary bile acid biosynthesis_Homo sapiens_hsa001201.18260861
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16383813
74RNA degradation_Homo sapiens_hsa030181.14395493
75ECM-receptor interaction_Homo sapiens_hsa045121.14041687
76Homologous recombination_Homo sapiens_hsa034401.12151266
77HTLV-I infection_Homo sapiens_hsa051661.11762275
78Peroxisome_Homo sapiens_hsa041461.11301851
79Measles_Homo sapiens_hsa051621.11287809
80Tuberculosis_Homo sapiens_hsa051521.10345658
81Bladder cancer_Homo sapiens_hsa052191.10234505
82Viral myocarditis_Homo sapiens_hsa054161.09395382
83Viral carcinogenesis_Homo sapiens_hsa052031.09166194
84Intestinal immune network for IgA production_Homo sapiens_hsa046721.08467341
85Allograft rejection_Homo sapiens_hsa053301.07522251
86Graft-versus-host disease_Homo sapiens_hsa053321.07231867
87Focal adhesion_Homo sapiens_hsa045101.06512554
88Epstein-Barr virus infection_Homo sapiens_hsa051691.04641808
89Vitamin digestion and absorption_Homo sapiens_hsa049771.03889595
90Other glycan degradation_Homo sapiens_hsa005111.03799812
91TNF signaling pathway_Homo sapiens_hsa046681.03461372
92Pancreatic cancer_Homo sapiens_hsa052121.02843616
93Pyrimidine metabolism_Homo sapiens_hsa002401.00750671
94Morphine addiction_Homo sapiens_hsa050321.00293181
95Leukocyte transendothelial migration_Homo sapiens_hsa046701.00017982
96Influenza A_Homo sapiens_hsa051640.99625018
97Adherens junction_Homo sapiens_hsa045200.99043350
98Acute myeloid leukemia_Homo sapiens_hsa052210.98172992
99Primary immunodeficiency_Homo sapiens_hsa053400.96094659
100Autoimmune thyroid disease_Homo sapiens_hsa053200.94118030
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93402053
102Salmonella infection_Homo sapiens_hsa051320.91986948
103Serotonergic synapse_Homo sapiens_hsa047260.91973638
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91198974
105Taste transduction_Homo sapiens_hsa047420.90034453
106Phagosome_Homo sapiens_hsa041450.89687786
107Amoebiasis_Homo sapiens_hsa051460.89427098
108Retinol metabolism_Homo sapiens_hsa008300.89209376
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88817020
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87594680
111Arachidonic acid metabolism_Homo sapiens_hsa005900.83916067
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82893996
113Colorectal cancer_Homo sapiens_hsa052100.82784390
114Melanoma_Homo sapiens_hsa052180.80607668
115TGF-beta signaling pathway_Homo sapiens_hsa043500.80157777
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79959188
117HIF-1 signaling pathway_Homo sapiens_hsa040660.78619125
118Type I diabetes mellitus_Homo sapiens_hsa049400.78089470
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77525078
120Chemical carcinogenesis_Homo sapiens_hsa052040.77444328
121RNA polymerase_Homo sapiens_hsa030200.77037494
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76741919
123Purine metabolism_Homo sapiens_hsa002300.76101744
124Notch signaling pathway_Homo sapiens_hsa043300.75920714
125Hippo signaling pathway_Homo sapiens_hsa043900.74893561
126Hematopoietic cell lineage_Homo sapiens_hsa046400.73766274
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72258088
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.71827488
129Olfactory transduction_Homo sapiens_hsa047400.71797750
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70908477
131Asthma_Homo sapiens_hsa053100.70385287
132Pathways in cancer_Homo sapiens_hsa052000.69909904
133Systemic lupus erythematosus_Homo sapiens_hsa053220.67047993
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.66861666
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66236256
136GABAergic synapse_Homo sapiens_hsa047270.64987194
137Propanoate metabolism_Homo sapiens_hsa006400.64578147
138N-Glycan biosynthesis_Homo sapiens_hsa005100.64317871
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63957354
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63697150
141Sulfur relay system_Homo sapiens_hsa041220.63203349
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62268763
143Glutamatergic synapse_Homo sapiens_hsa047240.62197146
144Basal cell carcinoma_Homo sapiens_hsa052170.61990856
145Mineral absorption_Homo sapiens_hsa049780.61397578
146Steroid biosynthesis_Homo sapiens_hsa001000.60242587
147Thyroid cancer_Homo sapiens_hsa052160.59163147
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58692184
149Fat digestion and absorption_Homo sapiens_hsa049750.58285944
150Metabolic pathways_Homo sapiens_hsa011000.58281634
151Pentose phosphate pathway_Homo sapiens_hsa000300.57507776
152Hepatitis C_Homo sapiens_hsa051600.57258284
153Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57128826
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56883791
155Glycerolipid metabolism_Homo sapiens_hsa005610.55834269
156Insulin secretion_Homo sapiens_hsa049110.54368533
157Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54352514
158Prostate cancer_Homo sapiens_hsa052150.54102002
159Non-homologous end-joining_Homo sapiens_hsa034500.53333900
160Prion diseases_Homo sapiens_hsa050200.51824571
161Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51550356
162Glutathione metabolism_Homo sapiens_hsa004800.51327200
163Platelet activation_Homo sapiens_hsa046110.50881381
164Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50154068
165Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49472229
166Central carbon metabolism in cancer_Homo sapiens_hsa052300.49235665
167Circadian entrainment_Homo sapiens_hsa047130.49183582
168Hedgehog signaling pathway_Homo sapiens_hsa043400.48704281
169ABC transporters_Homo sapiens_hsa020100.47798438
170Calcium signaling pathway_Homo sapiens_hsa040200.46575639
171Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45666276
172Cocaine addiction_Homo sapiens_hsa050300.45610270
173beta-Alanine metabolism_Homo sapiens_hsa004100.45055146
174Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44681998
175Steroid hormone biosynthesis_Homo sapiens_hsa001400.41950802
176Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40554316
177Cysteine and methionine metabolism_Homo sapiens_hsa002700.37283651
178Fatty acid biosynthesis_Homo sapiens_hsa000610.35918248
179Ovarian steroidogenesis_Homo sapiens_hsa049130.34057390

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