S1PR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.52558727
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.12234082
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.12234082
4antigen processing and presentation of endogenous antigen (GO:0019883)5.47831129
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.31477501
6positive regulation by symbiont of host defense response (GO:0052509)5.21554517
7modulation by symbiont of host defense response (GO:0052031)5.21554517
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.21554517
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.21554517
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.21554517
11modulation by symbiont of host immune response (GO:0052553)5.21554517
12ribosomal small subunit assembly (GO:0000028)5.09711153
13neutrophil activation involved in immune response (GO:0002283)5.04562253
14detection of bacterium (GO:0016045)5.01575419
15regulation of gamma-delta T cell differentiation (GO:0045586)4.99619957
16detection of other organism (GO:0098543)4.98214381
17regulation of gamma-delta T cell activation (GO:0046643)4.71384374
18negative T cell selection (GO:0043383)4.57965435
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.52427832
20negative thymic T cell selection (GO:0045060)4.48730954
21regulation of B cell receptor signaling pathway (GO:0050855)4.41634136
22negative regulation of lymphocyte mediated immunity (GO:0002707)4.38202133
23positive thymic T cell selection (GO:0045059)4.35045459
24response to interleukin-15 (GO:0070672)4.34947128
25viral transcription (GO:0019083)4.32224027
26T cell migration (GO:0072678)4.29690257
27leukocyte aggregation (GO:0070486)4.28110922
28macrophage activation involved in immune response (GO:0002281)4.27434989
29respiratory burst (GO:0045730)4.18634680
30translational termination (GO:0006415)4.09470284
31cellular response to interleukin-15 (GO:0071350)4.08536158
32B cell receptor signaling pathway (GO:0050853)4.02382945
33interferon-gamma production (GO:0032609)4.02116952
34response to peptidoglycan (GO:0032494)3.99541653
35regulation of B cell differentiation (GO:0045577)3.98732237
36detection of external biotic stimulus (GO:0098581)3.93353834
37neutrophil activation (GO:0042119)3.92873079
38negative regulation of leukocyte mediated immunity (GO:0002704)3.88005385
39positive regulation of B cell differentiation (GO:0045579)3.87482393
40thymic T cell selection (GO:0045061)3.86193813
41cellular extravasation (GO:0045123)3.84707534
42negative regulation of interleukin-12 production (GO:0032695)3.82537241
43antigen processing and presentation via MHC class Ib (GO:0002475)3.81175055
44regulation of interferon-beta biosynthetic process (GO:0045357)3.79597511
45negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.79591729
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.77045300
47leukocyte migration involved in inflammatory response (GO:0002523)3.76473358
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.75835980
49negative regulation of cell killing (GO:0031342)3.75835980
50positive T cell selection (GO:0043368)3.75806276
51DNA deamination (GO:0045006)3.71589004
52negative regulation of T cell mediated immunity (GO:0002710)3.70270943
53T cell selection (GO:0045058)3.69046152
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.65485757
55response to host immune response (GO:0052572)3.65485757
56T cell homeostasis (GO:0043029)3.63077407
57translational elongation (GO:0006414)3.62504344
58regulation of isotype switching to IgG isotypes (GO:0048302)3.62488275
59regulation of mast cell degranulation (GO:0043304)3.61372885
60regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.58667709
61ribosomal small subunit biogenesis (GO:0042274)3.58179423
62regulation of T cell receptor signaling pathway (GO:0050856)3.57355659
63myeloid cell activation involved in immune response (GO:0002275)3.56991496
64mast cell activation (GO:0045576)3.56758518
65antigen receptor-mediated signaling pathway (GO:0050851)3.54623304
66regulation of T cell tolerance induction (GO:0002664)3.54491690
67granulocyte activation (GO:0036230)3.52688169
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.52286432
69T cell receptor signaling pathway (GO:0050852)3.48498190
70Arp2/3 complex-mediated actin nucleation (GO:0034314)3.48101681
71cotranslational protein targeting to membrane (GO:0006613)3.41691362
72protein targeting to ER (GO:0045047)3.41095768
73detection of biotic stimulus (GO:0009595)3.40345110
74response to host (GO:0075136)3.38260825
75response to host defenses (GO:0052200)3.38260825
76response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.38260825
77B cell mediated immunity (GO:0019724)3.35146396
78regulation of tolerance induction (GO:0002643)3.34088262
79regulation of mast cell activation involved in immune response (GO:0033006)3.33384983
80leukocyte degranulation (GO:0043299)3.32946962
81positive regulation of T cell mediated cytotoxicity (GO:0001916)3.32036148
82regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.31015090
83regulation of natural killer cell mediated immunity (GO:0002715)3.31015090
84regulation of dendritic cell antigen processing and presentation (GO:0002604)3.30351895
85regulation of T cell mediated cytotoxicity (GO:0001914)3.29554580
86T cell costimulation (GO:0031295)3.28278111
87positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.28154595
88positive regulation of granulocyte differentiation (GO:0030854)3.27542430
89microglial cell activation (GO:0001774)3.27364164
90lymphocyte costimulation (GO:0031294)3.27262776
91regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27022579
92nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26102531
93negative regulation of phagocytosis (GO:0050765)3.24519406
94establishment of protein localization to endoplasmic reticulum (GO:0072599)3.23225009
95protein localization to endoplasmic reticulum (GO:0070972)3.23075956
96positive regulation of isotype switching (GO:0045830)3.20902607
97viral life cycle (GO:0019058)3.19793618
98interferon-gamma-mediated signaling pathway (GO:0060333)3.18861796
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.18828943
100tolerance induction (GO:0002507)3.18213198
101activated T cell proliferation (GO:0050798)3.17573459
102neutrophil mediated immunity (GO:0002446)3.15793102
103regulation of interleukin-12 biosynthetic process (GO:0045075)3.15561663
104maturation of SSU-rRNA (GO:0030490)3.15416805
105negative regulation of T-helper cell differentiation (GO:0045623)3.15043911
106negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.15043911
107positive regulation of mast cell activation (GO:0033005)3.14463453
108positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.12816526
109mast cell degranulation (GO:0043303)3.12143731
110mast cell activation involved in immune response (GO:0002279)3.12143731
111response to muramyl dipeptide (GO:0032495)3.11329821
112lymphocyte homeostasis (GO:0002260)3.11074696
113regulation of leukocyte degranulation (GO:0043300)3.10776908
114regulation of antigen processing and presentation (GO:0002577)3.10408156
115positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09260703
116regulation of mast cell activation (GO:0033003)3.08941082
117negative regulation of erythrocyte differentiation (GO:0045647)3.08898150
118detection of molecule of bacterial origin (GO:0032490)3.08488773
119cellular protein complex disassembly (GO:0043624)3.07664092
120regulation of alpha-beta T cell proliferation (GO:0046640)3.07173837
121negative regulation of innate immune response (GO:0045824)3.04847706
122production of molecular mediator involved in inflammatory response (GO:0002532)3.04418218
123megakaryocyte development (GO:0035855)3.03940700
124macrophage activation (GO:0042116)3.01272229
125response to type I interferon (GO:0034340)3.00251850
126response to protozoan (GO:0001562)2.98791761
127positive regulation of antigen processing and presentation (GO:0002579)2.96824322
128natural killer cell activation (GO:0030101)2.96674688
129cellular response to type I interferon (GO:0071357)2.96643193
130type I interferon signaling pathway (GO:0060337)2.96643193
131regulation of regulatory T cell differentiation (GO:0045589)2.95617604
132definitive hemopoiesis (GO:0060216)2.92234626
133NIK/NF-kappaB signaling (GO:0038061)2.92076865
134lymph node development (GO:0048535)2.90129123
135leukocyte homeostasis (GO:0001776)2.88948719
136defense response to protozoan (GO:0042832)2.88921297
137regulation of type I interferon-mediated signaling pathway (GO:0060338)2.87419254
138mature B cell differentiation (GO:0002335)2.86054052
139regulation of isotype switching (GO:0045191)2.85928217
140translational initiation (GO:0006413)2.85235084
141positive regulation of DNA recombination (GO:0045911)2.83932648
142negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.83098008
143regulation of B cell mediated immunity (GO:0002712)2.82729351
144regulation of response to interferon-gamma (GO:0060330)2.81161391
145positive regulation of alpha-beta T cell proliferation (GO:0046641)2.80779389
146positive regulation of interleukin-2 production (GO:0032743)2.79900592
147regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.79149996
148protein complex disassembly (GO:0043241)2.77815244
149cellular response to zinc ion (GO:0071294)2.76677796
150regulation of immunoglobulin mediated immune response (GO:0002889)2.76242209
151positive regulation of B cell mediated immunity (GO:0002714)2.75749028
152positive regulation of immunoglobulin mediated immune response (GO:0002891)2.75749028
153natural killer cell differentiation (GO:0001779)2.73642069
154myeloid dendritic cell activation (GO:0001773)2.73130839
155sequestering of actin monomers (GO:0042989)2.72835570
156immunoglobulin mediated immune response (GO:0016064)2.72638057
157leukocyte cell-cell adhesion (GO:0007159)2.72353182
158mature B cell differentiation involved in immune response (GO:0002313)2.72339461
159T cell differentiation (GO:0030217)2.70608075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.75751876
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.93805104
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88789853
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.87803173
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.43275553
6MYC_22102868_ChIP-Seq_BL_Human3.38096928
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31084463
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.99668943
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.92398774
10SCL_19346495_ChIP-Seq_HPC-7_Human2.88171057
11* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.71949628
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65367923
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61304338
14VDR_21846776_ChIP-Seq_THP-1_Human2.60813193
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.57949044
16MYB_26560356_Chip-Seq_TH2_Human2.53880331
17* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.43401517
18* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.40468831
19MAF_26560356_Chip-Seq_TH1_Human2.39918795
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.36552038
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36510667
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.34867939
23* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.33325517
24RUNX_20019798_ChIP-Seq_JUKART_Human2.27952366
25* MYB_26560356_Chip-Seq_TH1_Human2.25210822
26* SPI1_23547873_ChIP-Seq_NB4_Human2.25122723
27UTX_26944678_Chip-Seq_JUKART_Human2.22630068
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20514840
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07050107
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.02615154
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02044674
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.00219907
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.99215891
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.93630387
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.90870247
36CIITA_25753668_ChIP-Seq_RAJI_Human1.86844050
37VDR_24763502_ChIP-Seq_THP-1_Human1.84832854
38* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.82011258
39VDR_23849224_ChIP-Seq_CD4+_Human1.80253521
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79027449
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77577331
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77198393
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74919370
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73807898
45MAF_26560356_Chip-Seq_TH2_Human1.72891810
46FOXP3_21729870_ChIP-Seq_TREG_Human1.70752796
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.69981528
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68449124
49* TCF7_22412390_ChIP-Seq_EML_Mouse1.66528207
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.65960487
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.63434960
52* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.56156804
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55737765
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55009963
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54500760
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53785182
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.48713857
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47599013
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.45466693
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43993996
61BCL6_27268052_Chip-Seq_Bcells_Human1.42825394
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42566307
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41195624
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41139409
65LXR_22292898_ChIP-Seq_THP-1_Human1.39204158
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38487452
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38023735
68* GATA3_27048872_Chip-Seq_THYMUS_Human1.35003573
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34165899
70GATA1_22025678_ChIP-Seq_K562_Human1.34086103
71* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33964493
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.32866913
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30883425
74XRN2_22483619_ChIP-Seq_HELA_Human1.30817433
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29666544
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29608072
77SPI1_23127762_ChIP-Seq_K562_Human1.29377594
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29038462
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25797488
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25712746
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24723381
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24261169
83GATA1_19941826_ChIP-Seq_K562_Human1.23786101
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23597885
85BCOR_27268052_Chip-Seq_Bcells_Human1.23146134
86VDR_24787735_ChIP-Seq_THP-1_Human1.22504105
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21730482
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21538983
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20117656
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18988173
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.17864292
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17797924
93FOXM1_23109430_ChIP-Seq_U2OS_Human1.17778113
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.17370122
95MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15898712
96* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14664812
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12413967
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11021771
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11016455
100KDM2B_26808549_Chip-Seq_DND41_Human1.09472628
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07499831
102GABP_19822575_ChIP-Seq_HepG2_Human1.07378697
103* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07056574
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.06480704
105ELK1_19687146_ChIP-ChIP_HELA_Human1.05185471
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04967939
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03614665
108* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03369172
109SPI1_20517297_ChIP-Seq_HL60_Human1.02794425
110ELK3_25401928_ChIP-Seq_HUVEC_Human1.02658203
111* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02222795
112PU_27001747_Chip-Seq_BMDM_Mouse1.01790537
113* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00351781
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99641337
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99553044
116GATA3_26560356_Chip-Seq_TH2_Human0.98614450
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97867354
118P68_20966046_ChIP-Seq_HELA_Human0.97798440
119NCOR1_26117541_ChIP-Seq_K562_Human0.97726209
120SRF_21415370_ChIP-Seq_HL-1_Mouse0.97493298
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95305787
122* SA1_27219007_Chip-Seq_ERYTHROID_Human0.95203326
123NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94938993
124SMAD_19615063_ChIP-ChIP_OVARY_Human0.93948027
125DCP1A_22483619_ChIP-Seq_HELA_Human0.93931884
126E2F1_21310950_ChIP-Seq_MCF-7_Human0.92758287
127KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92437199
128* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91692958
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90890199
130P300_27268052_Chip-Seq_Bcells_Human0.90815273
131TTF2_22483619_ChIP-Seq_HELA_Human0.89050520
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87269844
133CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86397124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.14040313
2MP0005671_abnormal_response_to3.85498823
3MP0001835_abnormal_antigen_presentation3.84986976
4MP0000685_abnormal_immune_system3.54794587
5MP0002396_abnormal_hematopoietic_system3.38722646
6MP0001800_abnormal_humoral_immune3.30418995
7MP0009785_altered_susceptibility_to3.01651567
8MP0001790_abnormal_immune_system2.97379401
9MP0005387_immune_system_phenotype2.97379401
10MP0002398_abnormal_bone_marrow2.92133356
11MP0002420_abnormal_adaptive_immunity2.86126191
12MP0001819_abnormal_immune_cell2.81662142
13MP0005000_abnormal_immune_tolerance2.79468747
14MP0002452_abnormal_antigen_presenting2.78662826
15MP0002723_abnormal_immune_serum2.77748622
16MP0005025_abnormal_response_to2.61222889
17MP0000716_abnormal_immune_system2.50561936
18MP0009333_abnormal_splenocyte_physiolog2.49563021
19MP0003436_decreased_susceptibility_to2.41409676
20MP0000689_abnormal_spleen_morphology2.39139148
21MP0002166_altered_tumor_susceptibility2.35738208
22MP0002722_abnormal_immune_system2.35334094
23MP0004808_abnormal_hematopoietic_stem2.26060565
24MP0003724_increased_susceptibility_to2.25817543
25MP0005464_abnormal_platelet_physiology2.24773901
26MP0000703_abnormal_thymus_morphology2.21330489
27MP0002405_respiratory_system_inflammati2.17706780
28MP0002429_abnormal_blood_cell2.17299744
29MP0002419_abnormal_innate_immunity2.11775428
30MP0001873_stomach_inflammation2.11305064
31MP0010155_abnormal_intestine_physiology2.09151929
32MP0002148_abnormal_hypersensitivity_rea2.02626950
33MP0005397_hematopoietic_system_phenotyp1.99092422
34MP0001545_abnormal_hematopoietic_system1.99092422
35MP0003866_abnormal_defecation1.92568887
36MP0002006_tumorigenesis1.89681838
37MP0001853_heart_inflammation1.77485197
38MP0000490_abnormal_crypts_of1.74555808
39MP0003303_peritoneal_inflammation1.72291651
40MP0001845_abnormal_inflammatory_respons1.70260662
41MP0000465_gastrointestinal_hemorrhage1.68404051
42MP0005075_abnormal_melanosome_morpholog1.67597656
43MP0005174_abnormal_tail_pigmentation1.66503667
44MP0006082_CNS_inflammation1.66132832
45MP0002933_joint_inflammation1.57702334
46MP0008260_abnormal_autophagy1.56262855
47MP0003183_abnormal_peptide_metabolism1.55097498
48MP0002132_abnormal_respiratory_system1.54434919
49MP0004947_skin_inflammation1.47632559
50MP0003693_abnormal_embryo_hatching1.39151554
51MP0003300_gastrointestinal_ulcer1.39134988
52MP0000858_altered_metastatic_potential1.38781606
53MP0009278_abnormal_bone_marrow1.32260415
54MP0002277_abnormal_respiratory_mucosa1.31653167
55MP0008057_abnormal_DNA_replication1.30044551
56MP0002019_abnormal_tumor_incidence1.29674598
57MP0005451_abnormal_body_composition1.28754145
58MP0003077_abnormal_cell_cycle1.25301253
59MP0008469_abnormal_protein_level1.22263389
60MP0005310_abnormal_salivary_gland1.20728760
61MP0010094_abnormal_chromosome_stability1.20489880
62MP0002095_abnormal_skin_pigmentation1.19935457
63MP0008058_abnormal_DNA_repair1.11015973
64MP0000015_abnormal_ear_pigmentation1.07563819
65MP0008007_abnormal_cellular_replicative1.06697336
66MP0004883_abnormal_blood_vessel1.06557344
67MP0006054_spinal_hemorrhage1.05172130
68MP0003806_abnormal_nucleotide_metabolis1.03949429
69MP0001533_abnormal_skeleton_physiology1.00153264
70MP0003111_abnormal_nucleus_morphology0.97843234
71MP0004510_myositis0.97724467
72MP0003075_altered_response_to0.94538509
73MP0004957_abnormal_blastocyst_morpholog0.94031567
74MP0005166_decreased_susceptibility_to0.93520851
75MP0003448_altered_tumor_morphology0.90256875
76MP0003690_abnormal_glial_cell0.88332737
77MP0003656_abnormal_erythrocyte_physiolo0.85958895
78MP0003172_abnormal_lysosome_physiology0.81440249
79MP0000313_abnormal_cell_death0.80560143
80MP0005390_skeleton_phenotype0.77700875
81MP0001986_abnormal_taste_sensitivity0.77317716
82MP0009764_decreased_sensitivity_to0.76107204
83MP0005164_abnormal_response_to0.75557342
84MP0005058_abnormal_lysosome_morphology0.73471921
85MP0003943_abnormal_hepatobiliary_system0.70199055
86MP0009763_increased_sensitivity_to0.70101097
87MP0008004_abnormal_stomach_pH0.68305097
88MP0001663_abnormal_digestive_system0.66120798
89MP0010352_gastrointestinal_tract_polyps0.65640260
90MP0000477_abnormal_intestine_morphology0.64968123
91MP0001851_eye_inflammation0.63758385
92MP0002928_abnormal_bile_duct0.62961435
93MP0009765_abnormal_xenobiotic_induced0.60780561
94MP0008874_decreased_physiological_sensi0.60139058
95MP0004381_abnormal_hair_follicle0.59354017
96MP0005381_digestive/alimentary_phenotyp0.57177053
97MP0003045_fibrosis0.55546949
98MP0004130_abnormal_muscle_cell0.55237483
99MP0000343_altered_response_to0.54636182
100MP0002138_abnormal_hepatobiliary_system0.54569397
101MP0003786_premature_aging0.53804522
102MP0005083_abnormal_biliary_tract0.53752336
103MP0002009_preneoplasia0.53029771
104MP0000350_abnormal_cell_proliferation0.52447118
105MP0002998_abnormal_bone_remodeling0.51331878
106MP0003191_abnormal_cellular_cholesterol0.50427225
107MP0008873_increased_physiological_sensi0.50363024
108MP0005319_abnormal_enzyme/_coenzyme0.50048907
109MP0005023_abnormal_wound_healing0.49963195
110MP0000604_amyloidosis0.49579457
111MP0005084_abnormal_gallbladder_morpholo0.48914232
112MP0003828_pulmonary_edema0.47184915
113MP0003795_abnormal_bone_structure0.44757027
114MP0003279_aneurysm0.44450402
115MP0009379_abnormal_foot_pigmentation0.44100460
116MP0002693_abnormal_pancreas_physiology0.43786573
117MP0002136_abnormal_kidney_physiology0.42712673
118MP0000249_abnormal_blood_vessel0.41646903
119MP0000598_abnormal_liver_morphology0.41529751
120MP0000371_diluted_coat_color0.41365732
121MP0000609_abnormal_liver_physiology0.39661126
122MP0004147_increased_porphyrin_level0.39380248
123MP0002083_premature_death0.38949034
124MP0005376_homeostasis/metabolism_phenot0.38601861
125MP0000470_abnormal_stomach_morphology0.37408532

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)5.56198252
2Recurrent bronchitis (HP:0002837)5.11313882
3Recurrent gram-negative bacterial infections (HP:0005420)4.92704722
4Elevated erythrocyte sedimentation rate (HP:0003565)4.73054295
5Chronic otitis media (HP:0000389)4.66336612
6Panhypogammaglobulinemia (HP:0003139)4.43208603
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.41461571
8T lymphocytopenia (HP:0005403)4.36731004
9Agammaglobulinemia (HP:0004432)4.23680834
10Abnormality of T cells (HP:0002843)4.22850173
11Abnormality of T cell number (HP:0011839)4.18253944
12Recurrent viral infections (HP:0004429)4.11005140
13Gastrointestinal infarctions (HP:0005244)3.98712513
14Myositis (HP:0100614)3.98491108
15Recurrent fungal infections (HP:0002841)3.98481710
16B lymphocytopenia (HP:0010976)3.90325711
17Abnormality of B cell number (HP:0010975)3.90325711
18Recurrent abscess formation (HP:0002722)3.87784097
19Abnormality of T cell physiology (HP:0011840)3.87661851
20Nasal polyposis (HP:0100582)3.87147557
21Thrombocytosis (HP:0001894)3.82055048
22Abnormality of the nasal mucosa (HP:0000433)3.73157694
23Hypochromic microcytic anemia (HP:0004840)3.72966723
24Hypochromic anemia (HP:0001931)3.71210941
25Meningitis (HP:0001287)3.70149524
26IgG deficiency (HP:0004315)3.65330210
27Prolonged bleeding time (HP:0003010)3.64822186
28Urticaria (HP:0001025)3.59150209
29Eczematoid dermatitis (HP:0000976)3.51909848
30Chronic mucocutaneous candidiasis (HP:0002728)3.50084224
31Recurrent cutaneous fungal infections (HP:0011370)3.50084224
32Abnormality of cells of the erythroid lineage (HP:0012130)3.50081790
33Lymphopenia (HP:0001888)3.49770294
34Abnormal number of erythroid precursors (HP:0012131)3.48983789
35Cellulitis (HP:0100658)3.38351343
36Abnormality of cells of the lymphoid lineage (HP:0012140)3.38306779
37Pustule (HP:0200039)3.37183334
38Inflammation of the large intestine (HP:0002037)3.36362311
39Gastrointestinal inflammation (HP:0004386)3.36242783
40Gingivitis (HP:0000230)3.34094961
41Petechiae (HP:0000967)3.30565141
42Recurrent sinusitis (HP:0011108)3.29744323
43Severe combined immunodeficiency (HP:0004430)3.27071826
44Keratoconjunctivitis sicca (HP:0001097)3.24030712
45Reticulocytopenia (HP:0001896)3.18158238
46Recurrent bacterial skin infections (HP:0005406)3.17224962
47Spontaneous hematomas (HP:0007420)3.15312330
48Combined immunodeficiency (HP:0005387)3.13336940
49Keratoconjunctivitis (HP:0001096)3.10657255
50Aplastic anemia (HP:0001915)2.98340236
51Chronic sinusitis (HP:0011109)2.97038481
52Episodic fever (HP:0001954)2.95890807
53Pulmonary infiltrates (HP:0002113)2.95424054
54Gastrointestinal stroma tumor (HP:0100723)2.93276047
55Stomatitis (HP:0010280)2.91479708
56Bronchitis (HP:0012387)2.90663224
57Epistaxis (HP:0000421)2.89834254
58Verrucae (HP:0200043)2.89702990
59Papilloma (HP:0012740)2.89702990
60Mediastinal lymphadenopathy (HP:0100721)2.88723338
61Recurrent skin infections (HP:0001581)2.84827123
62Thyroiditis (HP:0100646)2.83964673
63Vasculitis (HP:0002633)2.82671201
64Lymphoma (HP:0002665)2.79535545
65Encephalitis (HP:0002383)2.75052923
66Colitis (HP:0002583)2.74030395
67Chronic obstructive pulmonary disease (HP:0006510)2.73277582
68Obstructive lung disease (HP:0006536)2.73277582
69Abnormality of the fingertips (HP:0001211)2.65183074
70Granulocytopenia (HP:0001913)2.54359173
71Abnormality of eosinophils (HP:0001879)2.53770990
72Pulmonary embolism (HP:0002204)2.50915925
73Autoimmune thrombocytopenia (HP:0001973)2.50368696
74Anorexia (HP:0002039)2.49701332
75Basal cell carcinoma (HP:0002671)2.47203289
76Leukocytosis (HP:0001974)2.44034384
77Eosinophilia (HP:0001880)2.41947126
78Hypoplasia of the thymus (HP:0000778)2.41860474
79Abnormality of macrophages (HP:0004311)2.39388936
80Chronic diarrhea (HP:0002028)2.38952098
81Abnormality of the pleura (HP:0002103)2.38687777
82Pallor (HP:0000980)2.38131692
83IgA deficiency (HP:0002720)2.36074592
84Autoimmune hemolytic anemia (HP:0001890)2.35544618
85Increased IgE level (HP:0003212)2.33766371
86Hepatosplenomegaly (HP:0001433)2.33690401
87Arterial thrombosis (HP:0004420)2.32024851
88Neutropenia (HP:0001875)2.30041020
89Poikiloderma (HP:0001029)2.29999905
90Microcytic anemia (HP:0001935)2.26611490
91Hemoptysis (HP:0002105)2.25884780
92Optic neuritis (HP:0100653)2.23882567
93Retrobulbar optic neuritis (HP:0100654)2.23882567
94Increased serum ferritin (HP:0003281)2.21991427
95Orchitis (HP:0100796)2.19318530
96Acute hepatic failure (HP:0006554)2.17236800
97Recurrent otitis media (HP:0000403)2.15625960
98Emphysema (HP:0002097)2.14202929
99Hypergammaglobulinemia (HP:0010702)2.13958093
100Abnormality of iron homeostasis (HP:0011031)2.12979604
101Gangrene (HP:0100758)2.12082290
102Purpura (HP:0000979)2.11466588
103Type I transferrin isoform profile (HP:0003642)2.10089733
104Abnormal platelet function (HP:0011869)2.09092393
105Impaired platelet aggregation (HP:0003540)2.09092393
106Recurrent pneumonia (HP:0006532)2.05541699
107Gingival bleeding (HP:0000225)2.04155546
108Chest pain (HP:0100749)2.03635598
109Osteomyelitis (HP:0002754)2.03535197
110Abnormality of the peritoneum (HP:0002585)2.03474950
111Interstitial pulmonary disease (HP:0006530)2.02659772
112Abnormal platelet volume (HP:0011876)2.02614968
113Recurrent lower respiratory tract infections (HP:0002783)2.02326992
114Restrictive lung disease (HP:0002091)2.01391698
115Muscle fiber atrophy (HP:0100295)2.00472879
116Abnormality of the heme biosynthetic pathway (HP:0010472)1.99925597
117Increased IgM level (HP:0003496)1.99454658
118Skin rash (HP:0000988)1.98762345
119Glomerulopathy (HP:0100820)1.98623386
120Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98404502
121Skin ulcer (HP:0200042)1.97834849
122Peritonitis (HP:0002586)1.96733508
123Hypertensive crisis (HP:0100735)1.96655691
124Joint swelling (HP:0001386)1.95936362
125Sepsis (HP:0100806)1.94655719
126Reduced antithrombin III activity (HP:0001976)1.93516575
127Abnormality of the pericardium (HP:0001697)1.91777693
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91531210
129Viral hepatitis (HP:0006562)1.90179605
130Slow saccadic eye movements (HP:0000514)1.87088868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.41949780
2TXK3.42321020
3EEF2K2.68091785
4ZAP702.65834593
5BLK2.54073882
6JAK32.53818424
7GRK62.42252350
8BTK2.31188227
9MAP3K102.29214404
10TEC2.22618718
11NME22.19497768
12PRPF4B2.19075008
13STK102.01749967
14TYK22.01129841
15KIT2.01018057
16ITK1.99198304
17IKBKE1.91574969
18KDR1.86833927
19TBK11.80567824
20IRAK41.80492771
21SYK1.79692451
22TGFBR21.74912435
23EPHB11.70848321
24TAOK11.70533780
25NLK1.62553264
26TGFBR11.62415614
27MAP3K31.58634503
28LRRK21.53500202
29LCK1.52115592
30CSF1R1.51646339
31FLT31.40985225
32MAP3K141.34941177
33TNK21.28662121
34IKBKB1.28535225
35FGR1.27762621
36STK161.25013896
37MAP2K31.22184388
38RPS6KA41.22134073
39JAK11.21384963
40CLK11.20055210
41ACVR1B1.19743821
42FGFR41.18983060
43FES1.18091346
44MAP3K11.17169737
45PIM11.12727849
46LYN1.12364703
47HCK1.10801278
48CSK1.07909982
49BMPR21.06706734
50SMG11.04412073
51MAP3K131.01157844
52RPS6KB21.00865714
53NEK20.95390172
54ERN10.93885581
55TAOK20.91632418
56TESK20.88843377
57IRAK30.88548240
58MARK20.88382706
59MARK30.88222037
60PKN20.86994273
61PASK0.82644809
62TNIK0.82052264
63WEE10.81927743
64DYRK30.81907631
65MAP2K60.79358371
66YES10.77140770
67SIK20.76129127
68FYN0.75788228
69FGFR30.75685713
70TLK10.75291252
71PIM20.73783279
72KSR20.72705516
73TRIB30.72390644
74MAP3K120.70596045
75CDK40.70122197
76PTK60.69211057
77SIK30.68068170
78CDC70.65430467
79EIF2AK30.65373522
80CDK190.64594306
81SCYL20.63998446
82ADRBK20.63106906
83MST40.62836671
84TAOK30.62247691
85MAP3K70.62066235
86PDPK10.61220153
87CAMKK10.60672373
88EIF2AK10.60649849
89BRSK20.60457479
90HIPK20.58465937
91STK40.58302025
92PRKCQ0.58149526
93JAK20.57587343
94STK110.57116421
95MAPK110.55991504
96ATR0.54835198
97PRKCH0.53772437
98VRK10.53306559
99DYRK1B0.52236211
100STK380.52126022
101RIPK40.51757407
102MAPK70.49179541
103PTK2B0.48542060
104IRAK10.47193995
105IRAK20.47063054
106MAPK40.46974584
107PRKD20.46812443
108CHUK0.46719676
109MAP3K60.46408324
110CDK70.46156880
111SIK10.45879687
112RPS6KA60.44722360
113RET0.44244671
114MAP3K50.43848997
115MAPKAPK20.43674571
116MAPKAPK30.43530399
117TRPM70.40159072
118PIK3CG0.39197070
119RAF10.38718866
120MAP3K110.36423001
121MAPK120.36087387
122STK240.35967766
123CDC42BPA0.34911708
124PRKG20.33659085
125CAMKK20.33122771
126SRPK10.32601088
127RPS6KC10.31620656
128RPS6KL10.31620656
129MAP3K80.30943332
130MATK0.29215735
131PRKCD0.29170628
132PDK10.28852847
133MAP2K40.28583467
134PRKD10.27916727
135BRSK10.26786258
136MAP2K20.25100921

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.94537389
2Ribosome_Homo sapiens_hsa030103.29886314
3DNA replication_Homo sapiens_hsa030302.83139591
4B cell receptor signaling pathway_Homo sapiens_hsa046622.44493061
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.40992021
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.40132753
7T cell receptor signaling pathway_Homo sapiens_hsa046602.38506342
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.34187609
9Measles_Homo sapiens_hsa051622.33211187
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.23317083
11Antigen processing and presentation_Homo sapiens_hsa046122.16940270
12Hematopoietic cell lineage_Homo sapiens_hsa046402.16112246
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12129975
14Mismatch repair_Homo sapiens_hsa034302.11705054
15Base excision repair_Homo sapiens_hsa034102.06074745
16Leishmaniasis_Homo sapiens_hsa051402.05914994
17Herpes simplex infection_Homo sapiens_hsa051681.77862704
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72895931
19Osteoclast differentiation_Homo sapiens_hsa043801.65701408
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.54868845
21Allograft rejection_Homo sapiens_hsa053301.54810407
22Graft-versus-host disease_Homo sapiens_hsa053321.51885573
23Homologous recombination_Homo sapiens_hsa034401.51751484
24Spliceosome_Homo sapiens_hsa030401.47829779
25Acute myeloid leukemia_Homo sapiens_hsa052211.38710806
26Non-homologous end-joining_Homo sapiens_hsa034501.35326228
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31472017
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30280192
29Shigellosis_Homo sapiens_hsa051311.30074259
30Nucleotide excision repair_Homo sapiens_hsa034201.29598968
31African trypanosomiasis_Homo sapiens_hsa051431.24329621
32Phagosome_Homo sapiens_hsa041451.22288090
33Pyrimidine metabolism_Homo sapiens_hsa002401.21546659
34Hepatitis B_Homo sapiens_hsa051611.15019500
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12497642
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12188239
37Influenza A_Homo sapiens_hsa051641.10557089
38Rheumatoid arthritis_Homo sapiens_hsa053231.08660397
39Epstein-Barr virus infection_Homo sapiens_hsa051691.08246381
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07434554
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.06638063
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06301836
43Chemokine signaling pathway_Homo sapiens_hsa040621.05754987
44RNA polymerase_Homo sapiens_hsa030201.05583338
45Apoptosis_Homo sapiens_hsa042101.04947708
46Platelet activation_Homo sapiens_hsa046111.04694085
47RNA degradation_Homo sapiens_hsa030181.02633302
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02010299
49Toxoplasmosis_Homo sapiens_hsa051451.00226724
50Legionellosis_Homo sapiens_hsa051341.00108287
51Proteasome_Homo sapiens_hsa030500.99698884
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96851506
53Viral myocarditis_Homo sapiens_hsa054160.94461427
54Fanconi anemia pathway_Homo sapiens_hsa034600.90757584
55Asthma_Homo sapiens_hsa053100.90708352
56Autoimmune thyroid disease_Homo sapiens_hsa053200.90429432
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89179390
58HTLV-I infection_Homo sapiens_hsa051660.88543563
59p53 signaling pathway_Homo sapiens_hsa041150.87528902
60Viral carcinogenesis_Homo sapiens_hsa052030.86824486
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84070050
62Tuberculosis_Homo sapiens_hsa051520.83878693
63TNF signaling pathway_Homo sapiens_hsa046680.83594356
64Cell cycle_Homo sapiens_hsa041100.81590425
65Pancreatic cancer_Homo sapiens_hsa052120.81223657
66Chronic myeloid leukemia_Homo sapiens_hsa052200.80317566
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78571863
68Pertussis_Homo sapiens_hsa051330.76716131
69Endocytosis_Homo sapiens_hsa041440.74858417
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70458021
71Sulfur relay system_Homo sapiens_hsa041220.70454111
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69925216
73Malaria_Homo sapiens_hsa051440.69220959
74Salmonella infection_Homo sapiens_hsa051320.67763281
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67583174
76RNA transport_Homo sapiens_hsa030130.67089413
77Hepatitis C_Homo sapiens_hsa051600.65228218
78Colorectal cancer_Homo sapiens_hsa052100.64651005
79Other glycan degradation_Homo sapiens_hsa005110.63938925
80Non-small cell lung cancer_Homo sapiens_hsa052230.63933886
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63682213
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63359906
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62819206
84N-Glycan biosynthesis_Homo sapiens_hsa005100.61735718
85Basal transcription factors_Homo sapiens_hsa030220.61432832
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.59697952
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58861027
88Pentose phosphate pathway_Homo sapiens_hsa000300.58531196
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.55520610
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54130021
91Renal cell carcinoma_Homo sapiens_hsa052110.53650820
92Choline metabolism in cancer_Homo sapiens_hsa052310.53338181
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53240794
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53214775
95Purine metabolism_Homo sapiens_hsa002300.53151571
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52804504
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52180515
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.51665527
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.51308425
100* Sphingolipid signaling pathway_Homo sapiens_hsa040710.50206856
101Protein export_Homo sapiens_hsa030600.49453142
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49153559
103Prolactin signaling pathway_Homo sapiens_hsa049170.49111064
104One carbon pool by folate_Homo sapiens_hsa006700.48777532
105Regulation of autophagy_Homo sapiens_hsa041400.48607355
106Staphylococcus aureus infection_Homo sapiens_hsa051500.48479547
107Systemic lupus erythematosus_Homo sapiens_hsa053220.46867041
108VEGF signaling pathway_Homo sapiens_hsa043700.46022124
109Inositol phosphate metabolism_Homo sapiens_hsa005620.45701770
110Notch signaling pathway_Homo sapiens_hsa043300.45280476
111Endometrial cancer_Homo sapiens_hsa052130.44488175
112* FoxO signaling pathway_Homo sapiens_hsa040680.44426434
113mTOR signaling pathway_Homo sapiens_hsa041500.43321087
114Small cell lung cancer_Homo sapiens_hsa052220.41241746
115Lysosome_Homo sapiens_hsa041420.39799731
116MAPK signaling pathway_Homo sapiens_hsa040100.39714496
117Thyroid cancer_Homo sapiens_hsa052160.39257495
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36208679
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35168656
120Caffeine metabolism_Homo sapiens_hsa002320.34582804
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34198810
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33818430
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.33283315
124mRNA surveillance pathway_Homo sapiens_hsa030150.33006871
125Insulin resistance_Homo sapiens_hsa049310.32805772
126Rap1 signaling pathway_Homo sapiens_hsa040150.31227585
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30968234
128HIF-1 signaling pathway_Homo sapiens_hsa040660.30366028
129Type I diabetes mellitus_Homo sapiens_hsa049400.27589987
130Amoebiasis_Homo sapiens_hsa051460.26078812
131Type II diabetes mellitus_Homo sapiens_hsa049300.24767105
132GnRH signaling pathway_Homo sapiens_hsa049120.24452604
133Dorso-ventral axis formation_Homo sapiens_hsa043200.22416534

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