S1PR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.62797574
2negative regulation of cell killing (GO:0031342)8.11838457
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.11838457
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.43934236
5ensheathment of neurons (GO:0007272)7.01173024
6axon ensheathment (GO:0008366)7.01173024
7myelination (GO:0042552)7.00709026
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.94310593
9long-chain fatty acid biosynthetic process (GO:0042759)6.52264650
10antigen processing and presentation of endogenous antigen (GO:0019883)6.51320463
11regulation of B cell receptor signaling pathway (GO:0050855)6.51035953
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.47116057
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.27804629
14leukocyte aggregation (GO:0070486)5.94769836
15positive regulation of gamma-delta T cell activation (GO:0046645)5.89846263
16activated T cell proliferation (GO:0050798)5.69457718
17cellular response to interleukin-15 (GO:0071350)5.27943580
18negative regulation of neurotransmitter secretion (GO:0046929)5.24459157
19cholesterol biosynthetic process (GO:0006695)5.20627385
20response to interleukin-15 (GO:0070672)5.15630976
21myelin maintenance (GO:0043217)5.13111458
22macrophage activation involved in immune response (GO:0002281)5.00424253
23neutrophil activation involved in immune response (GO:0002283)4.99232347
24positive regulation by symbiont of host defense response (GO:0052509)4.95074990
25modulation by symbiont of host defense response (GO:0052031)4.95074990
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.95074990
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.95074990
28positive regulation by organism of defense response of other organism involved in symbiotic interact4.95074990
29modulation by symbiont of host immune response (GO:0052553)4.95074990
30negative regulation of lymphocyte mediated immunity (GO:0002707)4.84297404
31amyloid precursor protein metabolic process (GO:0042982)4.84042057
32negative regulation of neurotransmitter transport (GO:0051589)4.83725313
33detection of bacterium (GO:0016045)4.80774315
34detection of other organism (GO:0098543)4.79522741
35sterol biosynthetic process (GO:0016126)4.58733991
36long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.50729124
37creatine metabolic process (GO:0006600)4.50467245
38L-amino acid import (GO:0043092)4.46590386
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.46249227
40regulation of natural killer cell mediated immunity (GO:0002715)4.46249227
41negative thymic T cell selection (GO:0045060)4.39808851
42negative T cell selection (GO:0043383)4.38573113
43response to methylmercury (GO:0051597)4.37467007
44establishment of mitochondrion localization (GO:0051654)4.37309403
45regulation of collateral sprouting (GO:0048670)4.32842419
46negative regulation of leukocyte mediated immunity (GO:0002704)4.30368389
47glycerophospholipid catabolic process (GO:0046475)4.29662805
48oligodendrocyte differentiation (GO:0048709)4.25949355
49regulation of gamma-delta T cell activation (GO:0046643)4.25762914
50positive thymic T cell selection (GO:0045059)4.25730053
51long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.18121960
52negative regulation of phagocytosis (GO:0050765)4.14414632
53negative regulation of protein localization to cell surface (GO:2000009)4.14202544
54neutrophil activation (GO:0042119)4.13180898
55T cell migration (GO:0072678)4.12925341
56microglial cell activation (GO:0001774)4.08300250
57regulation of gamma-delta T cell differentiation (GO:0045586)4.07848721
58import into cell (GO:0098657)4.02243098
59fatty-acyl-CoA biosynthetic process (GO:0046949)4.00731316
60cellular extravasation (GO:0045123)3.97985401
61apical protein localization (GO:0045176)3.92704786
62isoprenoid biosynthetic process (GO:0008299)3.92078314
63asymmetric protein localization (GO:0008105)3.90385560
64negative regulation of T cell mediated immunity (GO:0002710)3.85136669
65astrocyte development (GO:0014002)3.82711075
66positive regulation of oligodendrocyte differentiation (GO:0048714)3.81529185
67positive T cell selection (GO:0043368)3.81467512
68thymic T cell selection (GO:0045061)3.80730124
69substantia nigra development (GO:0021762)3.80170382
70regulation of T cell tolerance induction (GO:0002664)3.75841644
71fatty-acyl-CoA metabolic process (GO:0035337)3.75598020
72T cell selection (GO:0045058)3.74124812
73eye photoreceptor cell differentiation (GO:0001754)3.72050520
74photoreceptor cell differentiation (GO:0046530)3.72050520
75granulocyte activation (GO:0036230)3.70690137
76presynaptic membrane organization (GO:0097090)3.69915635
77amyloid precursor protein catabolic process (GO:0042987)3.68730743
78detection of external biotic stimulus (GO:0098581)3.68716764
79myeloid cell activation involved in immune response (GO:0002275)3.67236721
80very long-chain fatty acid metabolic process (GO:0000038)3.62592508
81peptidyl-tyrosine autophosphorylation (GO:0038083)3.60271341
82positive regulation of T cell mediated cytotoxicity (GO:0001916)3.58605960
83response to lipoprotein particle (GO:0055094)3.58459693
84regulation of B cell differentiation (GO:0045577)3.57562612
85regulation of isotype switching to IgG isotypes (GO:0048302)3.57170687
86negative regulation of interleukin-12 production (GO:0032695)3.57106800
87negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.55793709
88regulation of T cell mediated cytotoxicity (GO:0001914)3.55454260
89membrane tubulation (GO:0097320)3.51515717
90antigen processing and presentation via MHC class Ib (GO:0002475)3.48980107
91B cell receptor signaling pathway (GO:0050853)3.48785129
92interferon-gamma production (GO:0032609)3.48598101
93response to redox state (GO:0051775)3.48060135
94myelination in peripheral nervous system (GO:0022011)3.45510335
95peripheral nervous system axon ensheathment (GO:0032292)3.45510335
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.45176903
97regulation of leukocyte mediated cytotoxicity (GO:0001910)3.44173841
98response to type I interferon (GO:0034340)3.39700350
99respiratory burst (GO:0045730)3.38909720
100regulation of tolerance induction (GO:0002643)3.38354621
101presynaptic membrane assembly (GO:0097105)3.38294867
102regulation of lipoprotein metabolic process (GO:0050746)3.37631830
103positive regulation of natural killer cell mediated immunity (GO:0002717)3.37485199
104positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.36957374
105cellular response to type I interferon (GO:0071357)3.35370064
106type I interferon signaling pathway (GO:0060337)3.35370064
107adhesion of symbiont to host cell (GO:0044650)3.33742882
108virion attachment to host cell (GO:0019062)3.33742882
109erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.31973740
110L-phenylalanine catabolic process (GO:0006559)3.31973740
111regulation of interferon-beta biosynthetic process (GO:0045357)3.31117655
112macrophage activation (GO:0042116)3.30010402
113protein palmitoylation (GO:0018345)3.27825939
114regulation of alpha-beta T cell proliferation (GO:0046640)3.26439029
115regulation of mast cell degranulation (GO:0043304)3.26418412
116negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.26349450
117positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.25414118
118negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.23973273
119detection of biotic stimulus (GO:0009595)3.21906714
120immunoglobulin mediated immune response (GO:0016064)3.20179672
121positive regulation of cellular amine metabolic process (GO:0033240)3.20178091
122acyl-CoA biosynthetic process (GO:0071616)3.19820080
123thioester biosynthetic process (GO:0035384)3.19820080
124positive regulation of mast cell activation (GO:0033005)3.19057463
125adult walking behavior (GO:0007628)3.18507398
126negative regulation of type 2 immune response (GO:0002829)3.14674900
127amino acid import (GO:0043090)3.14424021
128response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.14169924
129response to host immune response (GO:0052572)3.14169924
130regulation of cell killing (GO:0031341)3.10185698
131negative regulation of innate immune response (GO:0045824)3.08957213
132regulation of regulatory T cell differentiation (GO:0045589)3.08905165
133magnesium ion transport (GO:0015693)3.08718678
134leukocyte degranulation (GO:0043299)3.06662119
135leukocyte cell-cell adhesion (GO:0007159)3.05310190
136response to peptidoglycan (GO:0032494)3.04817219
137cellular defense response (GO:0006968)3.04169975
138positive regulation of isotype switching (GO:0045830)3.03858647
139regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03779189
140positive regulation of B cell differentiation (GO:0045579)3.03692943
141positive regulation of cell killing (GO:0031343)3.01721947
142lymphocyte migration (GO:0072676)3.00584790
143antigen receptor-mediated signaling pathway (GO:0050851)2.99672342
144neuronal action potential propagation (GO:0019227)2.98839826
145negative regulation of axonogenesis (GO:0050771)2.98587061
146GPI anchor biosynthetic process (GO:0006506)2.98511804
147T cell receptor signaling pathway (GO:0050852)2.97851021
148regulation of mast cell activation involved in immune response (GO:0033006)2.96872659
149cerebral cortex radially oriented cell migration (GO:0021799)2.96865690
150axon development (GO:0061564)2.96144254
151GPI anchor metabolic process (GO:0006505)2.95936978
152nerve growth factor signaling pathway (GO:0038180)2.94824370
153response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91889068
154response to host (GO:0075136)2.91889068
155response to host defenses (GO:0052200)2.91889068
156myeloid leukocyte mediated immunity (GO:0002444)2.91521593
157positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.90636882
158signal complex assembly (GO:0007172)2.89739729
159glycosylceramide metabolic process (GO:0006677)2.88794209
160negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.88288316
161positive regulation of Rap GTPase activity (GO:0032854)2.87309014
162regulation of leukocyte degranulation (GO:0043300)2.86787047
163leukocyte migration involved in inflammatory response (GO:0002523)2.86264857
164nucleotide transmembrane transport (GO:1901679)2.86089227
165transmission of nerve impulse (GO:0019226)2.83856380
166positive regulation of action potential (GO:0045760)2.81014095
167limb bud formation (GO:0060174)2.78966450
168neurotransmitter uptake (GO:0001504)2.78691302
169protein localization to endosome (GO:0036010)2.77776509
170neuron remodeling (GO:0016322)2.76593331
171peptidyl-cysteine modification (GO:0018198)2.73843365
172erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.71708089
173L-phenylalanine metabolic process (GO:0006558)2.71708089
174heme transport (GO:0015886)2.70398167
175Golgi to endosome transport (GO:0006895)2.66659145
176response to lead ion (GO:0010288)2.66552156
177peripheral nervous system development (GO:0007422)2.65719590
178positive regulation of glial cell differentiation (GO:0045687)2.64556189
179iron coordination entity transport (GO:1901678)2.63113158
180cerebellar granule cell differentiation (GO:0021707)2.61295807
181preassembly of GPI anchor in ER membrane (GO:0016254)2.60991871
182negative regulation of execution phase of apoptosis (GO:1900118)2.58210214
183protein neddylation (GO:0045116)2.58175723
184glial cell development (GO:0021782)2.54151330
185negative regulation of acute inflammatory response (GO:0002674)2.52501794
186glutathione biosynthetic process (GO:0006750)2.52259356
187cholesterol metabolic process (GO:0008203)2.49747289
188negative regulation of JUN kinase activity (GO:0043508)2.49476543
189organ growth (GO:0035265)2.49303780
190regulation of interleukin-13 production (GO:0032656)2.48674112
191cellular response to epinephrine stimulus (GO:0071872)2.48552315
192neuronal ion channel clustering (GO:0045161)2.45389072
193neural nucleus development (GO:0048857)2.44931995
194ear development (GO:0043583)2.44578517
195negative regulation of axon extension (GO:0030517)2.41740778
196adhesion of symbiont to host (GO:0044406)2.41064445
197positive regulation of gliogenesis (GO:0014015)2.41010788
198central nervous system myelination (GO:0022010)11.7326522
199axon ensheathment in central nervous system (GO:0032291)11.7326522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.59917406
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.54955436
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.91280597
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.61147898
5RUNX_20019798_ChIP-Seq_JUKART_Human3.29465640
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.15438173
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.11159415
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.06279230
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04178909
10GBX2_23144817_ChIP-Seq_PC3_Human2.94748483
11SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.71044597
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68728986
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65120025
14MYB_26560356_Chip-Seq_TH2_Human2.60852546
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60725826
16VDR_21846776_ChIP-Seq_THP-1_Human2.58756698
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.57721820
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55087256
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.53423925
20MAF_26560356_Chip-Seq_TH1_Human2.50768196
21UTX_26944678_Chip-Seq_JUKART_Human2.44239751
22VDR_24763502_ChIP-Seq_THP-1_Human2.38972347
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.35018855
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31487458
25SPI1_23547873_ChIP-Seq_NB4_Human2.28350146
26TAF15_26573619_Chip-Seq_HEK293_Human2.27200652
27KDM2B_26808549_Chip-Seq_SUP-B15_Human2.25799686
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.25101391
29SPI1_23127762_ChIP-Seq_K562_Human2.23830956
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.22365524
31MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21630272
32STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17070854
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15422743
34MYB_26560356_Chip-Seq_TH1_Human2.14013049
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.11208257
36KDM2B_26808549_Chip-Seq_DND41_Human2.09360767
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09186733
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.05329533
39MAF_26560356_Chip-Seq_TH2_Human2.03742243
40* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03613397
41MYC_22102868_ChIP-Seq_BL_Human2.01880556
42* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00715593
43SCL_19346495_ChIP-Seq_HPC-7_Human2.00335459
44VDR_22108803_ChIP-Seq_LS180_Human1.93577919
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93092379
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92267007
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91469175
48TCF7_22412390_ChIP-Seq_EML_Mouse1.90841503
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87940453
50EZH2_22144423_ChIP-Seq_EOC_Human1.82821878
51* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82817826
52AR_21572438_ChIP-Seq_LNCaP_Human1.81451864
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80318136
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80318136
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80092303
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.79977367
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79894173
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79560434
59* EZH2_27304074_Chip-Seq_ESCs_Mouse1.79242670
60GATA3_27048872_Chip-Seq_THYMUS_Human1.78420305
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77197673
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76908477
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72778106
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72772384
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.72241157
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69452914
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69446366
68ER_23166858_ChIP-Seq_MCF-7_Human1.69430132
69* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67219912
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67025299
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66118787
72* EZH2_27294783_Chip-Seq_ESCs_Mouse1.65289775
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62257190
74* GATA1_19941827_ChIP-Seq_MEL_Mouse1.57038231
75LXR_22292898_ChIP-Seq_THP-1_Human1.55148345
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54671627
77DROSHA_22980978_ChIP-Seq_HELA_Human1.54096383
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51644659
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.51232529
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.48881826
81* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46796974
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46042056
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.44695101
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44301805
85* RNF2_27304074_Chip-Seq_ESCs_Mouse1.43994919
86* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40889870
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39884757
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37824243
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36965765
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36529024
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.35750601
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.35399683
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33401205
94HTT_18923047_ChIP-ChIP_STHdh_Human1.33325051
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33090910
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.33068243
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32063760
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31395633
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30315102
100ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29624971
101GATA3_26560356_Chip-Seq_TH2_Human1.29272350
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28597341
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28160870
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27978230
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27452732
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.27245677
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26553963
108NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26052249
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26052249
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23185467
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23173783
112VDR_24787735_ChIP-Seq_THP-1_Human1.22231173
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19863384
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19261961
115* BCL6_27268052_Chip-Seq_Bcells_Human1.18695285
116P300_19829295_ChIP-Seq_ESCs_Human1.16848935
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16762112
118* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14836495
119CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14610897
120* BCOR_27268052_Chip-Seq_Bcells_Human1.14161351
121RARB_27405468_Chip-Seq_BRAIN_Mouse1.13558107
122* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13348410
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13109548
124GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12897001
125PU_27001747_Chip-Seq_BMDM_Mouse1.12841977
126EOMES_21245162_ChIP-Seq_HESCs_Human1.11761055
127LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11359949
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10536421
129SA1_27219007_Chip-Seq_ERYTHROID_Human1.10200523
130Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09993816
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.09914799
132GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09884546
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09602683
134P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09513089
135PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08783344
136RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08505305
137FUS_26573619_Chip-Seq_HEK293_Human1.07909055
138PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06753109
139GATA1_19941826_ChIP-Seq_K562_Human1.05376167
140BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05291478
141CMYC_18555785_Chip-Seq_ESCs_Mouse1.04966768
142STAT3_23295773_ChIP-Seq_U87_Human1.02101366
143SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01943661
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01706630
145REST_21632747_ChIP-Seq_MESCs_Mouse1.01597451
146TP63_17297297_ChIP-ChIP_HaCaT_Human1.01562732
147CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00893856
148PRDM14_20953172_ChIP-Seq_ESCs_Human1.00259424
149TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99157055
150GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98916566
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.98798076
152* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98788025
153ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98290960
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97796360
155SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97526582
156EP300_21415370_ChIP-Seq_HL-1_Mouse0.97507521
157RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97161554
158SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96938441
159GATA1_26923725_Chip-Seq_HPCs_Mouse0.96724640
160SOX2_19829295_ChIP-Seq_ESCs_Human0.95798347
161NANOG_19829295_ChIP-Seq_ESCs_Human0.95798347
162SA1_27219007_Chip-Seq_Bcells_Human0.95644129
163PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94953553
164ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94860126
165P300_18555785_Chip-Seq_ESCs_Mouse0.94790433
166TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94666747
167MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94647668
168WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94157040
169PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93435217
170LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93070563
171RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92908553
172DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92498995
173EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92479600
174UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92007073
175ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91610403
176SPI1_20517297_ChIP-Seq_HL60_Human0.91208970
177BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90869420
178TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90831313
179SMC4_20622854_ChIP-Seq_HELA_Human0.89654814
180* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89652653
181SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89163098
182TCF4_23295773_ChIP-Seq_U87_Human0.88762636
183RNF2_27304074_Chip-Seq_NSC_Mouse0.88599432
184SMAD4_21741376_ChIP-Seq_EPCs_Human0.88245508
185SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87965423
186REST_18959480_ChIP-ChIP_MESCs_Mouse0.86796974
187TBL1_22424771_ChIP-Seq_293T_Human0.86612322
188SMAD4_21799915_ChIP-Seq_A2780_Human0.86604431
189GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86351542
190SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86130434
191IRF1_19129219_ChIP-ChIP_H3396_Human0.85933399
192OCT4_19829295_ChIP-Seq_ESCs_Human0.85928072
193RACK7_27058665_Chip-Seq_MCF-7_Human0.85888725
194NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84679009
195EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84389371
196ARNT_22903824_ChIP-Seq_MCF-7_Human0.83700996
197MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82773692
198FOXO3_23340844_ChIP-Seq_DLD1_Human0.82416276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.78582338
2MP0003724_increased_susceptibility_to4.25462960
3MP0005671_abnormal_response_to4.22139705
4MP0003950_abnormal_plasma_membrane3.94378220
5MP0003436_decreased_susceptibility_to3.92310534
6MP0003880_abnormal_central_pattern3.73013029
7MP0001835_abnormal_antigen_presentation3.60584940
8MP0003763_abnormal_thymus_physiology3.43157258
9MP0001800_abnormal_humoral_immune3.27015490
10MP0003329_amyloid_beta_deposits3.05843891
11MP0005000_abnormal_immune_tolerance3.04552662
12MP0004270_analgesia3.04277557
13MP0005025_abnormal_response_to3.03565733
14MP0002419_abnormal_innate_immunity2.94917761
15* MP0003690_abnormal_glial_cell2.81985592
16MP0002723_abnormal_immune_serum2.81141912
17MP0002420_abnormal_adaptive_immunity2.73811339
18MP0005387_immune_system_phenotype2.73148402
19MP0001790_abnormal_immune_system2.73148402
20MP0001819_abnormal_immune_cell2.69714764
21MP0003303_peritoneal_inflammation2.66914129
22MP0004885_abnormal_endolymph2.63794109
23MP0009785_altered_susceptibility_to2.62977832
24MP0001529_abnormal_vocalization2.62303986
25MP0000685_abnormal_immune_system2.60351573
26MP0003300_gastrointestinal_ulcer2.58923341
27MP0002452_abnormal_antigen_presenting2.58882973
28MP0003136_yellow_coat_color2.51561401
29MP0004742_abnormal_vestibular_system2.49536894
30MP0001905_abnormal_dopamine_level2.45924964
31MP0003634_abnormal_glial_cell2.42247931
32MP0002272_abnormal_nervous_system2.38240080
33MP0002132_abnormal_respiratory_system2.37074650
34MP0001486_abnormal_startle_reflex2.34013347
35MP0004142_abnormal_muscle_tone2.33869189
36MP0004381_abnormal_hair_follicle2.27934372
37MP0005451_abnormal_body_composition2.25560204
38MP0009333_abnormal_splenocyte_physiolog2.25417757
39MP0002405_respiratory_system_inflammati2.21669046
40MP0005171_absent_coat_pigmentation2.20234463
41MP0001485_abnormal_pinna_reflex2.15329778
42MP0002064_seizures2.12300840
43* MP0002398_abnormal_bone_marrow2.07316409
44MP0005409_darkened_coat_color2.05874693
45MP0003195_calcinosis2.04603311
46* MP0000716_abnormal_immune_system2.03258346
47MP0003632_abnormal_nervous_system1.98690791
48MP0010678_abnormal_skin_adnexa1.98630707
49MP0000778_abnormal_nervous_system1.98075610
50MP0004947_skin_inflammation1.97632297
51MP0001533_abnormal_skeleton_physiology1.89067737
52MP0000383_abnormal_hair_follicle1.86160712
53MP0002229_neurodegeneration1.86157505
54MP0005464_abnormal_platelet_physiology1.84638589
55MP0010155_abnormal_intestine_physiology1.81144431
56MP0000703_abnormal_thymus_morphology1.80712197
57MP0003806_abnormal_nucleotide_metabolis1.80427623
58MP0005410_abnormal_fertilization1.79057895
59MP0002148_abnormal_hypersensitivity_rea1.75648089
60MP0000858_altered_metastatic_potential1.74987066
61MP0000462_abnormal_digestive_system1.74864078
62MP0003866_abnormal_defecation1.73852524
63MP0004859_abnormal_synaptic_plasticity1.73344359
64MP0002722_abnormal_immune_system1.72242924
65MP0005423_abnormal_somatic_nervous1.71208651
66MP0009046_muscle_twitch1.69248034
67MP0000604_amyloidosis1.68442150
68MP0000689_abnormal_spleen_morphology1.68047896
69MP0001845_abnormal_inflammatory_respons1.65248762
70MP0004043_abnormal_pH_regulation1.57120091
71MP0009745_abnormal_behavioral_response1.56013336
72* MP0002429_abnormal_blood_cell1.55278804
73MP0008260_abnormal_autophagy1.54326177
74MP0003635_abnormal_synaptic_transmissio1.51593213
75MP0003631_nervous_system_phenotype1.49527340
76MP0003191_abnormal_cellular_cholesterol1.48224170
77MP0004883_abnormal_blood_vessel1.46194093
78MP0001873_stomach_inflammation1.43683219
79MP0002734_abnormal_mechanical_nocicepti1.38163382
80MP0008469_abnormal_protein_level1.36157144
81MP0005551_abnormal_eye_electrophysiolog1.34634996
82MP0000647_abnormal_sebaceous_gland1.32815388
83MP0000955_abnormal_spinal_cord1.30583804
84MP0003183_abnormal_peptide_metabolism1.30529529
85MP0003172_abnormal_lysosome_physiology1.29742894
86MP0000566_synostosis1.28273795
87MP0003633_abnormal_nervous_system1.27338659
88MP0008569_lethality_at_weaning1.27155888
89MP0002933_joint_inflammation1.26679854
90MP0002882_abnormal_neuron_morphology1.26378701
91MP0004147_increased_porphyrin_level1.26083128
92MP0004134_abnormal_chest_morphology1.21605776
93MP0002822_catalepsy1.21186311
94MP0002572_abnormal_emotion/affect_behav1.20228103
95MP0001440_abnormal_grooming_behavior1.18687102
96MP0002066_abnormal_motor_capabilities/c1.17298256
97MP0002998_abnormal_bone_remodeling1.16235619
98MP0000465_gastrointestinal_hemorrhage1.15418861
99MP0001346_abnormal_lacrimal_gland1.14799902
100MP0001661_extended_life_span1.13753112
101MP0003448_altered_tumor_morphology1.13739176
102MP0002396_abnormal_hematopoietic_system1.13638923
103MP0002277_abnormal_respiratory_mucosa1.12352195
104MP0003938_abnormal_ear_development1.10716469
105MP0002063_abnormal_learning/memory/cond1.09036544
106MP0003075_altered_response_to1.08976542
107MP0001299_abnormal_eye_distance/1.08787921
108MP0005386_behavior/neurological_phenoty1.08786676
109MP0004924_abnormal_behavior1.08786676
110MP0001851_eye_inflammation1.08384474
111MP0005166_decreased_susceptibility_to1.07948365
112MP0001963_abnormal_hearing_physiology1.07362683
113MP0000747_muscle_weakness1.07148213
114MP0005075_abnormal_melanosome_morpholog1.06066672
115MP0002752_abnormal_somatic_nervous1.05907486
116MP0009840_abnormal_foam_cell1.04051508
117MP0002067_abnormal_sensory_capabilities1.03670632
118MP0003828_pulmonary_edema1.02427273
119MP0005623_abnormal_meninges_morphology1.01969155
120MP0009278_abnormal_bone_marrow0.98946018
121MP0001970_abnormal_pain_threshold0.98584087
122MP0005164_abnormal_response_to0.98449003
123MP0000579_abnormal_nail_morphology0.98394306
124MP0000467_abnormal_esophagus_morphology0.97062890
125MP0005058_abnormal_lysosome_morphology0.96897188
126MP0006082_CNS_inflammation0.96426989
127MP0005195_abnormal_posterior_eye0.95333461
128MP0001177_atelectasis0.94366402
129MP0000490_abnormal_crypts_of0.92847508
130MP0005310_abnormal_salivary_gland0.91775803
131MP0001545_abnormal_hematopoietic_system0.91207257
132MP0005397_hematopoietic_system_phenotyp0.91207257
133MP0005408_hypopigmentation0.88284073
134MP0001986_abnormal_taste_sensitivity0.88071175
135MP0003045_fibrosis0.87415289
136MP0009764_decreased_sensitivity_to0.86644505
137MP0004130_abnormal_muscle_cell0.86133007
138MP0002166_altered_tumor_susceptibility0.85729178
139MP0003937_abnormal_limbs/digits/tail_de0.82682865
140MP0000762_abnormal_tongue_morphology0.80985136
141MP0002796_impaired_skin_barrier0.80181786
142MP0002295_abnormal_pulmonary_circulatio0.78429975
143MP0003656_abnormal_erythrocyte_physiolo0.78396774
144MP0004510_myositis0.76894511
145MP0002733_abnormal_thermal_nociception0.74386046
146MP0001663_abnormal_digestive_system0.72882390
147MP0009763_increased_sensitivity_to0.72794056
148MP0000026_abnormal_inner_ear0.72203434
149MP0002152_abnormal_brain_morphology0.72131991
150MP0004185_abnormal_adipocyte_glucose0.70715976
151MP0008873_increased_physiological_sensi0.70566674
152MP0002090_abnormal_vision0.69413083
153MP0002118_abnormal_lipid_homeostasis0.68207068
154MP0004145_abnormal_muscle_electrophysio0.66928004
155MP0003878_abnormal_ear_physiology0.66515073
156MP0005377_hearing/vestibular/ear_phenot0.66515073
157MP0005253_abnormal_eye_physiology0.63651334
158MP0005390_skeleton_phenotype0.62614631
159MP0005332_abnormal_amino_acid0.61592936
160MP0001348_abnormal_lacrimal_gland0.61442774
161MP0004036_abnormal_muscle_relaxation0.60553519
162MP0002133_abnormal_respiratory_system0.59848114
163MP0005388_respiratory_system_phenotype0.59848114
164MP0001340_abnormal_eyelid_morphology0.59332993
165MP0002006_tumorigenesis0.58858869
166MP0001727_abnormal_embryo_implantation0.58229253
167MP0008875_abnormal_xenobiotic_pharmacok0.57959350
168MP0008874_decreased_physiological_sensi0.57040710
169MP0003453_abnormal_keratinocyte_physiol0.56110827
170MP0003638_abnormal_response/metabolism_0.55841138
171MP0003795_abnormal_bone_structure0.55621940
172MP0001968_abnormal_touch/_nociception0.54574828
173MP0006072_abnormal_retinal_apoptosis0.53781424
174MP0004264_abnormal_extraembryonic_tissu0.53624568
175MP0002019_abnormal_tumor_incidence0.53418010
176MP0004858_abnormal_nervous_system0.52799233
177MP0009765_abnormal_xenobiotic_induced0.52104677
178MP0001765_abnormal_ion_homeostasis0.50357669
179MP0000249_abnormal_blood_vessel0.48028872
180MP0003566_abnormal_cell_adhesion0.47039175
181MP0004484_altered_response_of0.45581507
182MP0005381_digestive/alimentary_phenotyp0.45290079
183MP0000470_abnormal_stomach_morphology0.44618510

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.84372182
2Neurofibrillary tangles (HP:0002185)6.60030542
3Degeneration of the lateral corticospinal tracts (HP:0002314)6.49055682
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.49055682
5Recurrent abscess formation (HP:0002722)6.29384132
6Recurrent bacterial skin infections (HP:0005406)5.66280212
7Myositis (HP:0100614)5.61220007
8Parakeratosis (HP:0001036)5.51115362
9Recurrent gram-negative bacterial infections (HP:0005420)5.40000709
10Abnormality of macrophages (HP:0004311)5.21577050
11Sensory axonal neuropathy (HP:0003390)5.03989302
12Elevated erythrocyte sedimentation rate (HP:0003565)4.94687892
13Abnormality of the corticospinal tract (HP:0002492)4.85507065
14Orchitis (HP:0100796)4.76009790
15Cerebral inclusion bodies (HP:0100314)4.72390045
16Stomatitis (HP:0010280)4.50633945
17T lymphocytopenia (HP:0005403)4.48821785
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.46791395
19Retrobulbar optic neuritis (HP:0100654)4.42823870
20Optic neuritis (HP:0100653)4.42823870
21Abnormality of T cell number (HP:0011839)4.33777227
22Peripheral hypomyelination (HP:0007182)4.30904339
23Abnormal delayed hypersensitivity skin test (HP:0002963)4.04610869
24Gastrointestinal infarctions (HP:0005244)3.99605493
25Increased IgE level (HP:0003212)3.98891090
26Cerebral hypomyelination (HP:0006808)3.96448852
27Encephalitis (HP:0002383)3.91972825
28Recurrent fungal infections (HP:0002841)3.87757338
29Onion bulb formation (HP:0003383)3.86955196
30Meningitis (HP:0001287)3.82985548
31Gingivitis (HP:0000230)3.76988790
32Recurrent skin infections (HP:0001581)3.63125147
33Spastic gait (HP:0002064)3.57962021
34Supranuclear gaze palsy (HP:0000605)3.57571074
35Chronic obstructive pulmonary disease (HP:0006510)3.53753985
36Obstructive lung disease (HP:0006536)3.53753985
37Mediastinal lymphadenopathy (HP:0100721)3.45136586
38Leukocytosis (HP:0001974)3.44430582
39Hemiplegia (HP:0002301)3.43520901
40Intention tremor (HP:0002080)3.42787889
41Pustule (HP:0200039)3.40532392
42Congenital ichthyosiform erythroderma (HP:0007431)3.38562390
43Vasculitis (HP:0002633)3.31722293
44Abnormality of T cells (HP:0002843)3.30724809
45Nasal polyposis (HP:0100582)3.29806028
46Insidious onset (HP:0003587)3.29253947
47Termporal pattern (HP:0011008)3.29253947
48Hypochromic anemia (HP:0001931)3.27800832
49Keratoconjunctivitis sicca (HP:0001097)3.26119321
50Urticaria (HP:0001025)3.23605817
51Spontaneous hematomas (HP:0007420)3.21838110
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.17817927
53Increased IgM level (HP:0003496)3.11454893
54Abnormality of glycolysis (HP:0004366)3.11385511
55Increased serum pyruvate (HP:0003542)3.11385511
56Dysmetria (HP:0001310)3.11364331
57Panhypogammaglobulinemia (HP:0003139)3.07326116
58Abnormal auditory evoked potentials (HP:0006958)3.06706214
59Hypochromic microcytic anemia (HP:0004840)3.04205967
60Leukodystrophy (HP:0002415)3.00475738
61Chest pain (HP:0100749)3.00230927
62Keratoconjunctivitis (HP:0001096)2.99914130
63Prolonged bleeding time (HP:0003010)2.97258554
64Granulocytopenia (HP:0001913)2.96560375
65Scanning speech (HP:0002168)2.96016087
66Slow saccadic eye movements (HP:0000514)2.95597153
67Cellulitis (HP:0100658)2.92916706
68Recurrent cutaneous fungal infections (HP:0011370)2.89073502
69Chronic mucocutaneous candidiasis (HP:0002728)2.89073502
70Alacrima (HP:0000522)2.85235839
71Retinal dysplasia (HP:0007973)2.84958297
72Papilledema (HP:0001085)2.77980251
73Anteriorly placed anus (HP:0001545)2.77779548
74Spastic paraparesis (HP:0002313)2.76704610
75Recurrent viral infections (HP:0004429)2.76527159
76Inflammation of the large intestine (HP:0002037)2.76206830
77Eosinophilia (HP:0001880)2.75643976
78Episodic fever (HP:0001954)2.74121784
79Gastrointestinal inflammation (HP:0004386)2.70833043
80Cerebral hemorrhage (HP:0001342)2.67624962
81Lymphopenia (HP:0001888)2.65895854
82Pulmonary infiltrates (HP:0002113)2.64261075
83Gingival bleeding (HP:0000225)2.61930739
84Premature skin wrinkling (HP:0100678)2.60706570
85Clumsiness (HP:0002312)2.59411822
86Ankle clonus (HP:0011448)2.57759606
87Hypophosphatemic rickets (HP:0004912)2.57728191
88Abnormality of the nasal mucosa (HP:0000433)2.57208696
89Abnormality of cells of the lymphoid lineage (HP:0012140)2.55730272
90Stridor (HP:0010307)2.55495939
91Myokymia (HP:0002411)2.54567816
92Pulmonary embolism (HP:0002204)2.53773674
93Thickened helices (HP:0000391)2.52606778
94CNS hypomyelination (HP:0003429)2.52173726
95Hypergammaglobulinemia (HP:0010702)2.52163348
96Abnormality of eosinophils (HP:0001879)2.50478670
97Abnormality of aromatic amino acid family metabolism (HP:0004338)2.44655083
98Akinesia (HP:0002304)2.44585519
99Absent septum pellucidum (HP:0001331)2.43972145
100Anorexia (HP:0002039)2.42223997
101Increased circulating renin level (HP:0000848)2.39827665
102Autoamputation (HP:0001218)2.39752680
103Abnormality of T cell physiology (HP:0011840)2.37268046
104Segmental peripheral demyelination/remyelination (HP:0003481)2.36519439
105Epistaxis (HP:0000421)2.35411178
106Hemoptysis (HP:0002105)2.35408030
107Split foot (HP:0001839)2.32319349
108Chronic otitis media (HP:0000389)2.31494213
109Hypoplastic pelvis (HP:0008839)2.31097502
110Abnormality of binocular vision (HP:0011514)2.29275757
111Diplopia (HP:0000651)2.29275757
112IgM deficiency (HP:0002850)2.27050141
113Spastic tetraparesis (HP:0001285)2.26854775
114Erythroderma (HP:0001019)2.24542146
115Periodontitis (HP:0000704)2.23434805
116Coronal craniosynostosis (HP:0004440)2.21922353
117Decreased lacrimation (HP:0000633)2.20107580
118Sepsis (HP:0100806)2.19664416
119Arterial thrombosis (HP:0004420)2.19580185
120Severe combined immunodeficiency (HP:0004430)2.18049469
121Morphological abnormality of the inner ear (HP:0011390)2.17418085
122Pheochromocytoma (HP:0002666)2.16915296
123Microcytic anemia (HP:0001935)2.15315964
124Recurrent bronchitis (HP:0002837)2.15104148
125Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13717243
126Papilloma (HP:0012740)2.11015430
127Verrucae (HP:0200043)2.11015430
128Increased CSF protein (HP:0002922)2.10629111
129Skin ulcer (HP:0200042)2.09445163
130Axonal loss (HP:0003447)2.09442011
131Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09309694
132Colitis (HP:0002583)2.09048931
133Peritonitis (HP:0002586)2.08956387
134Gangrene (HP:0100758)2.07579057
135Methylmalonic acidemia (HP:0002912)2.07087462
136Hepatosplenomegaly (HP:0001433)2.07041671
137Abnormality of the septum pellucidum (HP:0007375)2.06823355
138Hyperlipoproteinemia (HP:0010980)2.06819700
139Metabolic alkalosis (HP:0200114)2.05955909
140Amyloidosis (HP:0011034)2.05861519
141Cupped ear (HP:0000378)2.05544022
142Joint swelling (HP:0001386)2.05448572
143Paraparesis (HP:0002385)2.05104751
144Aplasia involving bones of the upper limbs (HP:0009823)2.04981448
145Aplasia of the phalanges of the hand (HP:0009802)2.04981448
146Aplasia involving bones of the extremities (HP:0009825)2.04981448
147Lower limb muscle weakness (HP:0007340)2.04393274
148Petechiae (HP:0000967)2.03301854
149Esophageal atresia (HP:0002032)2.02750010
150Acute hepatic failure (HP:0006554)2.01865727
151Purpura (HP:0000979)2.01541604
152Poor speech (HP:0002465)2.01308882
153Hypoproteinemia (HP:0003075)2.01011083
154Agammaglobulinemia (HP:0004432)1.99730677
155Megalencephaly (HP:0001355)1.98956916
156Hypomagnesemia (HP:0002917)1.98921535
157Global brain atrophy (HP:0002283)1.98174984
158Increased serum ferritin (HP:0003281)1.96811770
159Renal Fanconi syndrome (HP:0001994)1.96289797
160Hypokalemic alkalosis (HP:0001949)1.95558655
161Autoimmune hemolytic anemia (HP:0001890)1.94652921
162Prolonged neonatal jaundice (HP:0006579)1.93906688
163Osteomyelitis (HP:0002754)1.93173529
164Synostosis involving the elbow (HP:0003938)1.93069470
165Humeroradial synostosis (HP:0003041)1.93069470
166Neuroendocrine neoplasm (HP:0100634)1.92856917
167Morphological abnormality of the pyramidal tract (HP:0002062)1.91168435
168Intrahepatic cholestasis (HP:0001406)1.90533405
169Anomalous pulmonary venous return (HP:0010772)1.90445455
170Premature loss of primary teeth (HP:0006323)1.90425638
171Hypoplasia of the iris (HP:0007676)1.90292282
172Tetraplegia (HP:0002445)1.89093496
173Gastrointestinal stroma tumor (HP:0100723)1.86713997
174Foot dorsiflexor weakness (HP:0009027)1.85733909
175Patchy hypopigmentation of hair (HP:0011365)1.85386469
176White forelock (HP:0002211)1.85046760
177Hyporeflexia of lower limbs (HP:0002600)1.84126296
178Infantile muscular hypotonia (HP:0008947)1.83856175
1793-Methylglutaconic aciduria (HP:0003535)1.83127184
180Disinhibition (HP:0000734)1.82699602
181Acne (HP:0001061)1.82103750
182Partial duplication of thumb phalanx (HP:0009944)1.81197364
183Abnormality of iron homeostasis (HP:0011031)1.81018748
184Choreoathetosis (HP:0001266)1.80449187
185Stenosis of the external auditory canal (HP:0000402)1.80328934
186Muscle fiber splitting (HP:0003555)1.79672719
187Abnormality of the pleura (HP:0002103)1.79163375
188Adrenal hypoplasia (HP:0000835)1.79022859
189Urinary incontinence (HP:0000020)1.78506103
190Decreased motor nerve conduction velocity (HP:0003431)1.78435159
191Vertigo (HP:0002321)1.78397183
192Clonus (HP:0002169)1.74943850
193Gowers sign (HP:0003391)1.73426880
194Barrel-shaped chest (HP:0001552)1.72209473
195Bowel incontinence (HP:0002607)1.72109158
196Abnormality of the middle phalanges of the toes (HP:0010183)1.71876670
197Hammertoe (HP:0001765)1.71854115
198Peripheral demyelination (HP:0011096)1.69798211
199Partial agenesis of the corpus callosum (HP:0001338)1.69103558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.72414072
2MAP4K14.81414118
3OXSR14.60271223
4RIPK44.34200969
5EPHB13.75249884
6WNK42.73270757
7BCR2.72483075
8PKN12.72289146
9CDK192.59730778
10TXK2.59219206
11GRK62.59206324
12ZAP702.56669975
13PBK2.46777975
14TYK22.45089775
15ERN12.41079824
16TNK22.40581805
17MAPKAPK52.35608895
18MET2.33157519
19BLK2.28161810
20FGFR22.25105845
21MAP2K32.21550828
22TNIK2.15481339
23IRAK42.13571732
24WNK12.05106649
25BTK2.00820127
26LIMK11.93734617
27UHMK11.81105478
28CSNK1G31.80317271
29JAK11.73672374
30CSNK1A1L1.72849764
31NEK61.70644490
32MAP3K31.65321445
33ICK1.64872193
34JAK31.62504744
35SYK1.62140827
36HCK1.62081063
37CLK11.60781785
38PNCK1.60567301
39CAMK2B1.60088636
40TESK21.58816277
41NTRK11.53790411
42TAOK31.53159056
43PRPF4B1.51912002
44LCK1.51086744
45ROCK21.50549008
46CSNK1G11.41070165
47MAP3K111.38553857
48CSNK1G21.37872955
49FGR1.36684295
50STK101.35566500
51MST41.32443273
52PAK61.30894849
53SIK31.30182951
54TAOK11.29831221
55CAMK2D1.29155738
56SGK2231.23418774
57SGK4941.23418774
58EPHA41.20634667
59IKBKE1.18261121
60LYN1.16178735
61MAP3K11.15330586
62JAK21.12656577
63CASK1.11387257
64CAMK2G1.07705324
65PAK31.00892665
66PTK2B1.00848772
67TYRO30.99243693
68PRKCQ0.96271645
69TBK10.95514116
70STK380.94445649
71MARK30.92609792
72DYRK20.92015218
73CSF1R0.87760244
74TEC0.86934280
75MARK20.85457680
76PTK60.83714212
77PRKD10.82065297
78BMPR20.81621023
79CAMK2A0.80310097
80MAP3K140.79856676
81SIK20.79627048
82MAP3K70.79583731
83CDK140.79351958
84MARK10.78886414
85TRIB30.78137989
86TGFBR20.77794810
87LRRK20.74653427
88ARAF0.74254738
89CDK50.74138314
90PDPK10.72919451
91MUSK0.70848653
92CDK150.70767107
93CAMKK10.69447070
94PIM10.68781207
95MAPK120.68770374
96YES10.66032260
97CDK180.64745476
98CDK11A0.64441448
99FGFR30.64018607
100PRKCE0.61160913
101SGK30.60848496
102MAPK150.57841239
103ERBB40.57444575
104IRAK20.55710283
105FYN0.54811707
106PIK3CA0.53884360
107RPS6KA50.53069440
108IKBKB0.52653538
109GRK50.52061056
110ITK0.51829728
111MAP3K60.51318164
112FGFR40.50878341
113RET0.49755222
114CSNK1D0.49188796
115CDK40.48235170
116GSK3A0.48211632
117HIPK20.47906474
118BMPR1B0.47841028
119KIT0.47769534
120SGK20.47630890
121STK110.47535634
122SMG10.46661566
123KDR0.46657312
124DMPK0.45339028
125PRKG10.44377512
126NTRK20.43906328
127PHKG20.43894009
128PHKG10.43894009
129CAMKK20.43347130
130TRPM70.43191279
131KSR20.41081629
132MAP3K20.40958884
133CDC42BPA0.40181291
134CSNK1A10.39782182
135MAP2K60.39242491
136SIK10.38138092
137CAMK1G0.37371987
138PRKACB0.37091020
139MAPK130.36063524
140GRK70.35803359
141PRKCH0.35237440
142FES0.34757276
143MAP2K40.34577033
144PAK10.34488646
145TESK10.34432508
146PDK10.34207825
147PRKCZ0.33287447
148RAF10.32985516
149TAOK20.32158868
150MAP2K20.32134027
151MAPKAPK20.31190887
152DYRK1B0.31185839
153NLK0.30952594
154PRKG20.30001307
155MAPK70.29922788
156ADRBK20.29221344
157RPS6KC10.28293153
158PRKD20.27065781
159PRKACA0.26719714
160INSR0.26302654
161DYRK1A0.25529847
162MAPK100.25132748
163PDGFRB0.24438061
164MKNK10.24167927
165MAP3K130.24115483
166BMX0.23776599
167IRAK10.23632520
168DAPK30.23289044
169OBSCN0.22651883
170ROCK10.22171485
171GRK10.21486507
172CSK0.21440333

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.51028474
2Steroid biosynthesis_Homo sapiens_hsa001004.88196876
3Fatty acid elongation_Homo sapiens_hsa000624.67206401
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.70028475
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.60872322
6Graft-versus-host disease_Homo sapiens_hsa053323.43281434
7Ether lipid metabolism_Homo sapiens_hsa005652.99988481
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.95629334
9Primary immunodeficiency_Homo sapiens_hsa053402.82814457
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.64958158
11Leishmaniasis_Homo sapiens_hsa051402.55737425
12Allograft rejection_Homo sapiens_hsa053302.53003088
13Osteoclast differentiation_Homo sapiens_hsa043802.52340453
14Antigen processing and presentation_Homo sapiens_hsa046122.26384846
15Sulfur metabolism_Homo sapiens_hsa009202.20317643
16T cell receptor signaling pathway_Homo sapiens_hsa046602.18806145
17B cell receptor signaling pathway_Homo sapiens_hsa046622.14010562
18Vitamin B6 metabolism_Homo sapiens_hsa007502.03214942
19Viral myocarditis_Homo sapiens_hsa054161.99676631
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97607354
21Type I diabetes mellitus_Homo sapiens_hsa049401.96030028
22Histidine metabolism_Homo sapiens_hsa003401.93825469
23Butanoate metabolism_Homo sapiens_hsa006501.74798751
24Tuberculosis_Homo sapiens_hsa051521.73398804
25Nitrogen metabolism_Homo sapiens_hsa009101.72494688
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72385436
27Linoleic acid metabolism_Homo sapiens_hsa005911.70187936
28Measles_Homo sapiens_hsa051621.67816570
29Sphingolipid metabolism_Homo sapiens_hsa006001.67557545
30Oxidative phosphorylation_Homo sapiens_hsa001901.66059462
31Chemokine signaling pathway_Homo sapiens_hsa040621.65525812
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63568244
33Axon guidance_Homo sapiens_hsa043601.63281103
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62874367
35Hematopoietic cell lineage_Homo sapiens_hsa046401.49937107
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49144263
37Acute myeloid leukemia_Homo sapiens_hsa052211.47568647
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44845959
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.40747134
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40410867
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.40066884
42Protein export_Homo sapiens_hsa030601.39533577
43Non-small cell lung cancer_Homo sapiens_hsa052231.37067470
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33523559
45Legionellosis_Homo sapiens_hsa051341.28069463
46Toxoplasmosis_Homo sapiens_hsa051451.23201203
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23138087
48Arginine and proline metabolism_Homo sapiens_hsa003301.17402299
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.17379510
50VEGF signaling pathway_Homo sapiens_hsa043701.16719538
51Alzheimers disease_Homo sapiens_hsa050101.14716752
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13254036
53GABAergic synapse_Homo sapiens_hsa047271.12581274
54Platelet activation_Homo sapiens_hsa046111.12267781
55Parkinsons disease_Homo sapiens_hsa050121.12121263
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10944894
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10147884
58Fatty acid metabolism_Homo sapiens_hsa012121.09087894
59Glutamatergic synapse_Homo sapiens_hsa047241.07209965
60Serotonergic synapse_Homo sapiens_hsa047261.05949402
61Herpes simplex infection_Homo sapiens_hsa051681.05356964
62Influenza A_Homo sapiens_hsa051641.04922254
63Renal cell carcinoma_Homo sapiens_hsa052111.03719308
64African trypanosomiasis_Homo sapiens_hsa051430.99702092
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97907376
66Pancreatic cancer_Homo sapiens_hsa052120.95896787
67Folate biosynthesis_Homo sapiens_hsa007900.94667397
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91633607
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.91622454
70Propanoate metabolism_Homo sapiens_hsa006400.89414541
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.89365405
72Pertussis_Homo sapiens_hsa051330.88968179
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.88389847
74Peroxisome_Homo sapiens_hsa041460.88126227
75Long-term depression_Homo sapiens_hsa047300.86633721
76Apoptosis_Homo sapiens_hsa042100.85588803
77Long-term potentiation_Homo sapiens_hsa047200.85311901
78TNF signaling pathway_Homo sapiens_hsa046680.85035571
79Hepatitis B_Homo sapiens_hsa051610.82705356
80Arachidonic acid metabolism_Homo sapiens_hsa005900.82456072
81Tight junction_Homo sapiens_hsa045300.82101884
82Hepatitis C_Homo sapiens_hsa051600.81837092
83Rap1 signaling pathway_Homo sapiens_hsa040150.81562546
84Chronic myeloid leukemia_Homo sapiens_hsa052200.81391589
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.79166006
86Glutathione metabolism_Homo sapiens_hsa004800.79127010
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79110518
88Shigellosis_Homo sapiens_hsa051310.76414590
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76232420
90Morphine addiction_Homo sapiens_hsa050320.76093561
91FoxO signaling pathway_Homo sapiens_hsa040680.73258256
92Collecting duct acid secretion_Homo sapiens_hsa049660.72439445
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.72196269
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71060715
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68508776
96Endocytosis_Homo sapiens_hsa041440.67087739
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67065343
98Retinol metabolism_Homo sapiens_hsa008300.66883881
99GnRH signaling pathway_Homo sapiens_hsa049120.65556891
100Autoimmune thyroid disease_Homo sapiens_hsa053200.64963690
101Endometrial cancer_Homo sapiens_hsa052130.64508696
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64422336
103Prolactin signaling pathway_Homo sapiens_hsa049170.64096250
104Colorectal cancer_Homo sapiens_hsa052100.62599616
105* Sphingolipid signaling pathway_Homo sapiens_hsa040710.62366144
106MAPK signaling pathway_Homo sapiens_hsa040100.62330264
107Ras signaling pathway_Homo sapiens_hsa040140.61743993
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61510762
109Cocaine addiction_Homo sapiens_hsa050300.61094426
110Vibrio cholerae infection_Homo sapiens_hsa051100.60966290
111HTLV-I infection_Homo sapiens_hsa051660.60949868
112Salmonella infection_Homo sapiens_hsa051320.60565391
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60478313
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59682977
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59598142
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57160962
117Chemical carcinogenesis_Homo sapiens_hsa052040.56486542
118Inositol phosphate metabolism_Homo sapiens_hsa005620.56401897
119Epstein-Barr virus infection_Homo sapiens_hsa051690.55968597
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.55824354
121Notch signaling pathway_Homo sapiens_hsa043300.55107893
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55036751
123Fatty acid biosynthesis_Homo sapiens_hsa000610.55018403
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54912693
125Rheumatoid arthritis_Homo sapiens_hsa053230.53879430
126Lysosome_Homo sapiens_hsa041420.53698933
127Ovarian steroidogenesis_Homo sapiens_hsa049130.53525556
128Amoebiasis_Homo sapiens_hsa051460.53230167
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52903388
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51221539
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.50799201
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50203656
133Cardiac muscle contraction_Homo sapiens_hsa042600.50150380
134Dorso-ventral axis formation_Homo sapiens_hsa043200.49331679
135mTOR signaling pathway_Homo sapiens_hsa041500.47936576
136Asthma_Homo sapiens_hsa053100.47576310
137Glioma_Homo sapiens_hsa052140.46183528
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.45803467
139Circadian entrainment_Homo sapiens_hsa047130.45518973
140Metabolic pathways_Homo sapiens_hsa011000.45331883
141Salivary secretion_Homo sapiens_hsa049700.45138985
142Mineral absorption_Homo sapiens_hsa049780.43826693
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43711630
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43597381
145Pancreatic secretion_Homo sapiens_hsa049720.43291600
146Tyrosine metabolism_Homo sapiens_hsa003500.42740163
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41357023
148* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41192100
149Viral carcinogenesis_Homo sapiens_hsa052030.41001715
150beta-Alanine metabolism_Homo sapiens_hsa004100.40512391
151Type II diabetes mellitus_Homo sapiens_hsa049300.40149497
152Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39667815
153Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39520834
154Estrogen signaling pathway_Homo sapiens_hsa049150.39283850
155ErbB signaling pathway_Homo sapiens_hsa040120.39173289
156Huntingtons disease_Homo sapiens_hsa050160.39169276
157Dopaminergic synapse_Homo sapiens_hsa047280.39050101
158Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38694082
159Gastric acid secretion_Homo sapiens_hsa049710.37386990
160Vitamin digestion and absorption_Homo sapiens_hsa049770.36824927
161Regulation of autophagy_Homo sapiens_hsa041400.36093351
162Phototransduction_Homo sapiens_hsa047440.35968116
163Malaria_Homo sapiens_hsa051440.35353736
164Cholinergic synapse_Homo sapiens_hsa047250.34277905
165Phagosome_Homo sapiens_hsa041450.34176187
166Pyruvate metabolism_Homo sapiens_hsa006200.33964095
167Nicotine addiction_Homo sapiens_hsa050330.33788672
168ABC transporters_Homo sapiens_hsa020100.32564183
169Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32343492
170Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32133122
171Complement and coagulation cascades_Homo sapiens_hsa046100.31220819
172Staphylococcus aureus infection_Homo sapiens_hsa051500.29288657
173Glycerolipid metabolism_Homo sapiens_hsa005610.27259350
174Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27229373
175Prion diseases_Homo sapiens_hsa050200.25657418
176Choline metabolism in cancer_Homo sapiens_hsa052310.23427544
177Fatty acid degradation_Homo sapiens_hsa000710.23068232

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