SAA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bile acid and bile salt transport (GO:0015721)7.66344016
2low-density lipoprotein particle clearance (GO:0034383)6.63306669
3triglyceride catabolic process (GO:0019433)6.54295499
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.25971003
5L-phenylalanine catabolic process (GO:0006559)6.25971003
6aromatic amino acid family catabolic process (GO:0009074)5.99979834
7L-phenylalanine metabolic process (GO:0006558)5.92738960
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.92738960
9neutral lipid catabolic process (GO:0046461)5.92314333
10acylglycerol catabolic process (GO:0046464)5.92314333
11tryptophan catabolic process (GO:0006569)5.88863134
12indole-containing compound catabolic process (GO:0042436)5.88863134
13indolalkylamine catabolic process (GO:0046218)5.88863134
14kynurenine metabolic process (GO:0070189)5.76729824
15regulation of protein activation cascade (GO:2000257)5.75109980
16complement activation, alternative pathway (GO:0006957)5.70850478
17* acute-phase response (GO:0006953)5.59119689
18pyrimidine-containing compound transmembrane transport (GO:0072531)5.51655880
19ethanol oxidation (GO:0006069)5.42560189
20sulfur amino acid catabolic process (GO:0000098)5.38635852
21tryptophan metabolic process (GO:0006568)5.37638598
22regulation of complement activation (GO:0030449)5.25657830
23negative regulation of fibrinolysis (GO:0051918)5.14553960
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.98742530
25regulation of fibrinolysis (GO:0051917)4.95833943
26regulation of sequestering of triglyceride (GO:0010889)4.90614154
27protein carboxylation (GO:0018214)4.77380610
28peptidyl-glutamic acid carboxylation (GO:0017187)4.77380610
29omega-hydroxylase P450 pathway (GO:0097267)4.77375773
30glyoxylate metabolic process (GO:0046487)4.75563461
31epoxygenase P450 pathway (GO:0019373)4.68965640
32bile acid biosynthetic process (GO:0006699)4.68289902
33regulation of triglyceride catabolic process (GO:0010896)4.67579061
34positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.61767834
35urea cycle (GO:0000050)4.61723797
36urea metabolic process (GO:0019627)4.61723797
37heme transport (GO:0015886)4.49211568
38ethanol metabolic process (GO:0006067)4.41162729
39bile acid metabolic process (GO:0008206)4.40081345
40homocysteine metabolic process (GO:0050667)4.32688279
41cysteine metabolic process (GO:0006534)4.32385271
42high-density lipoprotein particle remodeling (GO:0034375)4.29620776
43fatty acid homeostasis (GO:0055089)4.27167108
44alpha-linolenic acid metabolic process (GO:0036109)4.26028962
45aromatic amino acid family metabolic process (GO:0009072)4.26003865
46negative regulation of protein activation cascade (GO:2000258)4.25370144
47glycerolipid catabolic process (GO:0046503)4.21280997
48nitrogen cycle metabolic process (GO:0071941)4.19686581
49vitamin transmembrane transport (GO:0035461)4.13059911
50phospholipid efflux (GO:0033700)4.11593867
51opsonization (GO:0008228)4.07877168
52acylglycerol homeostasis (GO:0055090)4.06126703
53triglyceride homeostasis (GO:0070328)4.06126703
54primary alcohol metabolic process (GO:0034308)4.04777815
55indolalkylamine metabolic process (GO:0006586)4.03312183
56diacylglycerol metabolic process (GO:0046339)4.02384142
57protein-lipid complex remodeling (GO:0034368)3.99080280
58macromolecular complex remodeling (GO:0034367)3.99080280
59plasma lipoprotein particle remodeling (GO:0034369)3.99080280
60cellular glucuronidation (GO:0052695)3.98644614
61transcytosis (GO:0045056)3.97860494
62serine family amino acid catabolic process (GO:0009071)3.97243421
63complement activation, classical pathway (GO:0006958)3.93831207
64amine catabolic process (GO:0009310)3.91277885
65cellular biogenic amine catabolic process (GO:0042402)3.91277885
66regulation of bile acid biosynthetic process (GO:0070857)3.88687991
67protein activation cascade (GO:0072376)3.85497181
68negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.84487773
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.83977066
70reverse cholesterol transport (GO:0043691)3.83599335
71tyrosine metabolic process (GO:0006570)3.82556093
72fibrinolysis (GO:0042730)3.82536368
73complement activation (GO:0006956)3.80112279
74polyketide metabolic process (GO:0030638)3.79827482
75doxorubicin metabolic process (GO:0044598)3.79827482
76daunorubicin metabolic process (GO:0044597)3.79827482
77coenzyme catabolic process (GO:0009109)3.79747284
78* acute inflammatory response (GO:0002526)3.76947641
79benzene-containing compound metabolic process (GO:0042537)3.75614049
80drug metabolic process (GO:0017144)3.74943051
81primary alcohol catabolic process (GO:0034310)3.73407583
82oxaloacetate metabolic process (GO:0006107)3.70534954
83regulation of cholesterol homeostasis (GO:2000188)3.69602293
84response to dietary excess (GO:0002021)3.69482560
85lipid storage (GO:0019915)3.69379665
86cytolysis (GO:0019835)3.68557676
87NADH metabolic process (GO:0006734)3.66868510
88alpha-amino acid catabolic process (GO:1901606)3.66732423
89regulation of cholesterol esterification (GO:0010872)3.64458279
90negative regulation of sterol transport (GO:0032372)3.63922111
91negative regulation of cholesterol transport (GO:0032375)3.63922111
92pantothenate metabolic process (GO:0015939)3.62027674
93amino-acid betaine metabolic process (GO:0006577)3.60853169
94positive regulation of triglyceride lipase activity (GO:0061365)3.60727986
95positive regulation of lipoprotein lipase activity (GO:0051006)3.60727986
96regulation of protein glycosylation (GO:0060049)3.58346036
97regulation of plasminogen activation (GO:0010755)3.56746132
98cellular response to cadmium ion (GO:0071276)3.52439466
99arginine metabolic process (GO:0006525)3.51697272
100regulation of cholesterol metabolic process (GO:0090181)3.49567482
101lysine catabolic process (GO:0006554)3.49543167
102lysine metabolic process (GO:0006553)3.49543167
103uronic acid metabolic process (GO:0006063)3.49325607
104glucuronate metabolic process (GO:0019585)3.49325607
105positive regulation of glycoprotein biosynthetic process (GO:0010560)3.47634427
106cellular response to zinc ion (GO:0071294)3.44253714
107retinol metabolic process (GO:0042572)3.44004554
108cellular amino acid catabolic process (GO:0009063)3.42569681
109triglyceride metabolic process (GO:0006641)3.41446367
110drug catabolic process (GO:0042737)3.41265411
111cellular ketone body metabolic process (GO:0046950)3.40974363
112blood coagulation, intrinsic pathway (GO:0007597)3.40777076
113cholesterol homeostasis (GO:0042632)3.40061970
114response to phenylpropanoid (GO:0080184)3.39713166
115regulation of lipoprotein metabolic process (GO:0050746)3.39685819
116plasma lipoprotein particle clearance (GO:0034381)3.39371784
117biotin metabolic process (GO:0006768)3.36692413
118brown fat cell differentiation (GO:0050873)3.36363042
119glutamate metabolic process (GO:0006536)3.36007746
120sterol homeostasis (GO:0055092)3.35511279
121cellular modified amino acid catabolic process (GO:0042219)3.34598033
122imidazole-containing compound metabolic process (GO:0052803)3.33865902
123aminoglycoside antibiotic metabolic process (GO:0030647)3.33093030
124positive regulation of lipid catabolic process (GO:0050996)3.33009542
125regulation of humoral immune response (GO:0002920)3.32863931
126phospholipid homeostasis (GO:0055091)3.29064079
127negative regulation of hemostasis (GO:1900047)3.27907380
128negative regulation of blood coagulation (GO:0030195)3.27907380
129ovulation from ovarian follicle (GO:0001542)3.25747714
130exogenous drug catabolic process (GO:0042738)3.24903388
131regulation of triglyceride metabolic process (GO:0090207)3.22995807
132cholesterol efflux (GO:0033344)3.22554391
133positive regulation of fatty acid metabolic process (GO:0045923)3.21647471
134iron coordination entity transport (GO:1901678)3.21402703
135acylglycerol metabolic process (GO:0006639)3.20451636
136low-density lipoprotein particle remodeling (GO:0034374)3.20105548
137negative regulation of lipase activity (GO:0060192)3.18707889
138flavonoid metabolic process (GO:0009812)3.16771078
139neutral lipid metabolic process (GO:0006638)3.15048319
140cofactor catabolic process (GO:0051187)3.14790643
141positive regulation of lipid storage (GO:0010884)3.14679606
142negative regulation of complement activation (GO:0045916)3.12188658
143regulation of cholesterol transport (GO:0032374)3.10628587
144regulation of sterol transport (GO:0032371)3.10628587
145negative regulation of coagulation (GO:0050819)3.10138598
146cellular response to leptin stimulus (GO:0044320)3.07956114
147positive regulation of fatty acid biosynthetic process (GO:0045723)3.06468884
148glycine metabolic process (GO:0006544)3.05457804
149retinal metabolic process (GO:0042574)3.05424131
150positive regulation of triglyceride metabolic process (GO:0090208)3.05336194
151regulation of heterotypic cell-cell adhesion (GO:0034114)3.05287771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.85863005
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.68127693
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.89006121
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.65910168
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.20126676
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.77648662
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.28204329
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.15378015
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.66437552
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.75388389
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32427803
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.10722680
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92268368
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91761493
15SOX2_27498859_Chip-Seq_STOMACH_Mouse1.79967790
16TP63_17297297_ChIP-ChIP_HaCaT_Human1.79427821
17CLOCK_20551151_ChIP-Seq_293T_Human1.78894825
18ESR1_15608294_ChIP-ChIP_MCF-7_Human1.74943164
19* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74876600
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67069266
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59641929
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.56314555
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54506218
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.54278285
25SOX2_20726797_ChIP-Seq_SW620_Human1.52961277
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.49317589
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.42092859
28HTT_18923047_ChIP-ChIP_STHdh_Human1.38326931
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.37465543
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.36986490
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.36880340
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35390069
33PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.34272860
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31500604
35CJUN_26792858_Chip-Seq_BT549_Human1.31436088
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26228457
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.24170648
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.24170648
39GATA4_25053715_ChIP-Seq_YYC3_Human1.21586738
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21470049
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18578751
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17843018
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17445667
44* HNF4A_19822575_ChIP-Seq_HepG2_Human1.17131461
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16497207
46GATA6_25053715_ChIP-Seq_YYC3_Human1.13926270
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13459242
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12628705
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12620094
50PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.09428650
51BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08578041
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06408408
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05307129
54PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99153340
55ELK3_25401928_ChIP-Seq_HUVEC_Human0.98986069
56LXR_22292898_ChIP-Seq_THP-1_Human0.90241058
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90112423
58FOXO3_23340844_ChIP-Seq_DLD1_Human0.90014767
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89992409
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88879577
61RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87754227
62RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87315855
63SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85902002
64NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85823418
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85823418
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85160981
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83371238
68RACK7_27058665_Chip-Seq_MCF-7_Human0.83281861
69SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83006590
70FOXA1_25552417_ChIP-Seq_VCAP_Human0.82646024
71* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82644922
72SMC4_20622854_ChIP-Seq_HELA_Human0.81701339
73* CBP_21632823_ChIP-Seq_H3396_Human0.81134034
74SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80500072
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78771266
76SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78771266
77SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77681829
78SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76993562
79ERG_21242973_ChIP-ChIP_JURKAT_Human0.76880169
80SA1_22415368_ChIP-Seq_MEFs_Mouse0.76686173
81TAF2_19829295_ChIP-Seq_ESCs_Human0.76305738
82SMC1_22415368_ChIP-Seq_MEFs_Mouse0.75646291
83EP300_21415370_ChIP-Seq_HL-1_Mouse0.74939951
84NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74891831
85PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73018756
86JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72448647
87ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.71508506
88RARA_24833708_ChIP-Seq_LIVER_Mouse0.71497178
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71255875
90ZNF263_19887448_ChIP-Seq_K562_Human0.71206165
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71050785
92IRF8_22096565_ChIP-ChIP_GC-B_Human0.71018734
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70515708
94* MYC_19915707_ChIP-ChIP_AK7_Human0.69929666
95GATA1_22025678_ChIP-Seq_K562_Human0.69726831
96* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69228373
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69093590
98GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.68646535
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68563086
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.68511264
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.67762923
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.67465136
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.67416854
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.67183431
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.66736765
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.66525516
107STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.66207118
108CTCF_27219007_Chip-Seq_Bcells_Human0.65892195
109KAP1_22055183_ChIP-Seq_ESCs_Mouse0.64580666
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64502538
111GATA3_24758297_ChIP-Seq_MCF-7_Human0.63218948
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.63087574
113TET1_21451524_ChIP-Seq_MESCs_Mouse0.62718379
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.62625069
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.62096483
116DNAJC2_21179169_ChIP-ChIP_NT2_Human0.61803065
117BCAT_22108803_ChIP-Seq_LS180_Human0.60507126
118ZNF274_21170338_ChIP-Seq_K562_Hela0.58607172
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.58561076
120ATF3_27146783_Chip-Seq_COLON_Human0.58451537
121GATA2_19941826_ChIP-Seq_K562_Human0.58381654
122CREB1_26743006_Chip-Seq_LNCaP_Human0.58296075
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57952919
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.57927130
125ETV2_25802403_ChIP-Seq_MESCs_Mouse0.57131373
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.56362386
127GATA1_19941826_ChIP-Seq_K562_Human0.56352986
128RUNX1_27514584_Chip-Seq_MCF-7_Human0.56121080
129AR_21909140_ChIP-Seq_LNCAP_Human0.56116674
130RXR_22108803_ChIP-Seq_LS180_Human0.55694280
131P53_21459846_ChIP-Seq_SAOS-2_Human0.55583341
132EGR1_19032775_ChIP-ChIP_M12_Human0.55239934
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.54244921
134CSB_26484114_Chip-Seq_FIBROBLAST_Human0.53517875

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.46138437
2MP0002139_abnormal_hepatobiliary_system6.43427507
3MP0010234_abnormal_vibrissa_follicle6.15695016
4MP0005085_abnormal_gallbladder_physiolo5.68873645
5MP0005365_abnormal_bile_salt4.55749838
6MP0008875_abnormal_xenobiotic_pharmacok4.40052108
7MP0003806_abnormal_nucleotide_metabolis3.52298909
8MP0003191_abnormal_cellular_cholesterol3.46414376
9MP0003252_abnormal_bile_duct3.32421402
10MP0005375_adipose_tissue_phenotype3.17278332
11MP0010329_abnormal_lipoprotein_level3.04261679
12MP0001666_abnormal_nutrient_absorption2.71093186
13MP0002822_catalepsy2.47300607
14MP0005083_abnormal_biliary_tract2.18962750
15MP0009115_abnormal_fat_cell2.17981186
16MP0005257_abnormal_intraocular_pressure2.14692985
17MP0009840_abnormal_foam_cell2.09807310
18MP0004019_abnormal_vitamin_homeostasis2.07807548
19MP0005332_abnormal_amino_acid2.07272702
20MP0008438_abnormal_cutaneous_collagen1.90983967
21MP0003868_abnormal_feces_composition1.90906633
22MP0000003_abnormal_adipose_tissue1.90290696
23* MP0002118_abnormal_lipid_homeostasis1.85494010
24MP0003195_calcinosis1.84697248
25MP0003959_abnormal_lean_body1.80631151
26MP0000609_abnormal_liver_physiology1.77354995
27MP0003705_abnormal_hypodermis_morpholog1.76601746
28MP0002970_abnormal_white_adipose1.74906964
29MP0005670_abnormal_white_adipose1.73838883
30MP0003950_abnormal_plasma_membrane1.72239195
31MP0005275_abnormal_skin_tensile1.69886715
32MP0005319_abnormal_enzyme/_coenzyme1.68704290
33MP0002138_abnormal_hepatobiliary_system1.63983370
34MP0005503_abnormal_tendon_morphology1.61028643
35MP0005535_abnormal_body_temperature1.60736022
36MP0000604_amyloidosis1.57827518
37MP0004272_abnormal_basement_membrane1.56067761
38MP0004264_abnormal_extraembryonic_tissu1.44919039
39MP0005584_abnormal_enzyme/coenzyme_acti1.40971506
40MP0009643_abnormal_urine_homeostasis1.40877974
41MP0006138_congestive_heart_failure1.38678718
42MP0003828_pulmonary_edema1.37464586
43MP0003878_abnormal_ear_physiology1.30906975
44MP0005377_hearing/vestibular/ear_phenot1.30906975
45MP0005058_abnormal_lysosome_morphology1.25845815
46MP0005448_abnormal_energy_balance1.23046288
47MP0005167_abnormal_blood-brain_barrier1.21671680
48MP0010678_abnormal_skin_adnexa1.20815996
49MP0001879_abnormal_lymphatic_vessel1.18919292
50MP0003724_increased_susceptibility_to1.16238810
51MP0005164_abnormal_response_to1.15221615
52MP0002108_abnormal_muscle_morphology1.15034667
53MP0002796_impaired_skin_barrier1.14094668
54MP0005636_abnormal_mineral_homeostasis1.11592926
55MP0003011_delayed_dark_adaptation1.10407232
56MP0002254_reproductive_system_inflammat1.06842649
57MP0002909_abnormal_adrenal_gland1.06320662
58MP0000343_altered_response_to1.04394825
59MP0004185_abnormal_adipocyte_glucose1.04157348
60MP0005452_abnormal_adipose_tissue1.02809691
61MP0009785_altered_susceptibility_to1.02010294
62MP0001873_stomach_inflammation1.01779729
63MP0002876_abnormal_thyroid_physiology1.00387693
64MP0005451_abnormal_body_composition0.98982128
65MP0003566_abnormal_cell_adhesion0.98808830
66MP0001881_abnormal_mammary_gland0.98665924
67MP0001764_abnormal_homeostasis0.97722683
68MP0002295_abnormal_pulmonary_circulatio0.96781905
69MP0000598_abnormal_liver_morphology0.93953449
70MP0008469_abnormal_protein_level0.93886566
71MP0009764_decreased_sensitivity_to0.92785718
72MP0000249_abnormal_blood_vessel0.91891237
73MP0002971_abnormal_brown_adipose0.90787422
74MP0003453_abnormal_keratinocyte_physiol0.90344703
75MP0000751_myopathy0.88689312
76MP0000858_altered_metastatic_potential0.88586371
77MP0009763_increased_sensitivity_to0.87763862
78MP0009780_abnormal_chondrocyte_physiolo0.84661800
79MP0001663_abnormal_digestive_system0.84344535
80MP0005666_abnormal_adipose_tissue0.83719051
81MP0009053_abnormal_anal_canal0.83543004
82MP0008872_abnormal_physiological_respon0.81554800
83* MP0009642_abnormal_blood_homeostasis0.81153113
84MP0008873_increased_physiological_sensi0.80956811
85MP0005166_decreased_susceptibility_to0.80416922
86MP0003656_abnormal_erythrocyte_physiolo0.78507757
87MP0003866_abnormal_defecation0.78167591
88MP0002933_joint_inflammation0.77958091
89MP0002132_abnormal_respiratory_system0.75957939
90MP0000477_abnormal_intestine_morphology0.73837811
91MP0003300_gastrointestinal_ulcer0.72654135
92MP0004947_skin_inflammation0.72601774
93MP0005647_abnormal_sex_gland0.72311419
94MP0003279_aneurysm0.71947005
95MP0005595_abnormal_vascular_smooth0.71770317
96MP0005266_abnormal_metabolism0.71079322
97MP0010155_abnormal_intestine_physiology0.71041600
98MP0005381_digestive/alimentary_phenotyp0.70389166
99MP0001544_abnormal_cardiovascular_syste0.70231529
100MP0005385_cardiovascular_system_phenoty0.70231529
101MP0004130_abnormal_muscle_cell0.69945161
102MP0005379_endocrine/exocrine_gland_phen0.69049619
103MP0002098_abnormal_vibrissa_morphology0.66650940
104MP0000749_muscle_degeneration0.65614300
105MP0000013_abnormal_adipose_tissue0.65062130
106MP0004782_abnormal_surfactant_physiolog0.64554996
107MP0009384_cardiac_valve_regurgitation0.64117408
108MP0009765_abnormal_xenobiotic_induced0.63321387
109MP0005084_abnormal_gallbladder_morpholo0.63004064
110MP0010368_abnormal_lymphatic_system0.62889166
111MP0002060_abnormal_skin_morphology0.61162369
112MP0003690_abnormal_glial_cell0.60996110
113MP0001661_extended_life_span0.60250738
114MP0005165_increased_susceptibility_to0.59336320
115MP0003186_abnormal_redox_activity0.59216417
116MP0004215_abnormal_myocardial_fiber0.58914928
117MP0005023_abnormal_wound_healing0.58789217
118MP0000427_abnormal_hair_cycle0.58334738
119MP0001216_abnormal_epidermal_layer0.57813087
120MP0003953_abnormal_hormone_level0.57697099
121MP0001756_abnormal_urination0.57536935
122MP0001664_abnormal_digestion0.57500023
123MP0003075_altered_response_to0.56615632
124MP0000759_abnormal_skeletal_muscle0.56113719
125MP0000579_abnormal_nail_morphology0.55951979
126MP0003879_abnormal_hair_cell0.55308520
127MP0003436_decreased_susceptibility_to0.54789917
128MP0003303_peritoneal_inflammation0.54732062
129MP0004087_abnormal_muscle_fiber0.53688339
130MP0002136_abnormal_kidney_physiology0.53565506
131MP0005376_homeostasis/metabolism_phenot0.53381656
132MP0006035_abnormal_mitochondrial_morpho0.52825792
133MP0000383_abnormal_hair_follicle0.52666586
134MP0001501_abnormal_sleep_pattern0.52040422
135MP0000627_abnormal_mammary_gland0.51907022
136MP0005334_abnormal_fat_pad0.51826681
137MP0001765_abnormal_ion_homeostasis0.51533006
138MP0002078_abnormal_glucose_homeostasis0.50802321
139MP0009379_abnormal_foot_pigmentation0.50736605
140MP0005464_abnormal_platelet_physiology0.50432563
141MP0002638_abnormal_pupillary_reflex0.49063666
142MP0000377_abnormal_hair_follicle0.49049655
143MP0006036_abnormal_mitochondrial_physio0.47831325
144MP0001845_abnormal_inflammatory_respons0.46067598
145MP0003329_amyloid_beta_deposits0.45164692

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.65608774
2Deep venous thrombosis (HP:0002625)6.50966980
3Complement deficiency (HP:0004431)6.27220352
4Hyperlipoproteinemia (HP:0010980)6.24998106
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.09744054
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.99445040
7Xanthomatosis (HP:0000991)5.90903770
8Prolonged partial thromboplastin time (HP:0003645)5.75651427
9Spontaneous abortion (HP:0005268)5.21438618
10Abnormality of the common coagulation pathway (HP:0010990)4.94251060
11Acanthosis nigricans (HP:0000956)4.75145237
12Hypoalphalipoproteinemia (HP:0003233)4.69180592
13Abnormality of complement system (HP:0005339)4.63547575
14Hypertriglyceridemia (HP:0002155)4.62494396
15Hypobetalipoproteinemia (HP:0003563)4.61340012
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.48002037
17Malnutrition (HP:0004395)4.34918088
18Hypolipoproteinemia (HP:0010981)4.34140543
19Joint hemorrhage (HP:0005261)4.11544918
20Epidermoid cyst (HP:0200040)3.69385417
21Fat malabsorption (HP:0002630)3.69288077
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.68243522
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.65660376
24Hypoglycemic coma (HP:0001325)3.57506575
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.53822804
26Abnormality of the intrinsic pathway (HP:0010989)3.49745824
27Hyperammonemia (HP:0001987)3.48104232
28Hypercholesterolemia (HP:0003124)3.29461919
29Abnormality of methionine metabolism (HP:0010901)3.22860208
30Systemic lupus erythematosus (HP:0002725)3.14727067
31Oligomenorrhea (HP:0000876)3.10115620
32Hyperglycinemia (HP:0002154)3.09802817
33Ketosis (HP:0001946)3.08362203
34Protrusio acetabuli (HP:0003179)3.03040683
35Amyloidosis (HP:0011034)3.02437069
36Gingival bleeding (HP:0000225)3.01374983
37Insulin resistance (HP:0000855)2.98361184
38Conjugated hyperbilirubinemia (HP:0002908)2.97231761
39Abnormality of purine metabolism (HP:0004352)2.93604619
40Right ventricular cardiomyopathy (HP:0011663)2.92377913
41Abnormality of fatty-acid metabolism (HP:0004359)2.92129356
42Abnormality of small intestinal villus morphology (HP:0011472)2.88262799
43Villous atrophy (HP:0011473)2.88262799
44Steatorrhea (HP:0002570)2.84962163
45Abnormality of nucleobase metabolism (HP:0010932)2.82893272
46Myocardial infarction (HP:0001658)2.70856810
47Recurrent gram-negative bacterial infections (HP:0005420)2.69401176
48Increased serum pyruvate (HP:0003542)2.67975992
49Glomerulonephritis (HP:0000099)2.64281399
50Abnormality of serine family amino acid metabolism (HP:0010894)2.63542202
51Abnormality of glycine metabolism (HP:0010895)2.63542202
52Vertebral compression fractures (HP:0002953)2.62831724
53Abnormality of pyrimidine metabolism (HP:0004353)2.61470578
54Hyperglycinuria (HP:0003108)2.60627100
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.58101460
56Esophageal varix (HP:0002040)2.56991676
57Thrombophlebitis (HP:0004418)2.55278785
58Hyperbilirubinemia (HP:0002904)2.42639359
59Abnormal gallbladder physiology (HP:0012438)2.41411600
60Cholecystitis (HP:0001082)2.41411600
61Prostate neoplasm (HP:0100787)2.40763334
62Flat acetabular roof (HP:0003180)2.36892208
63Insulin-resistant diabetes mellitus (HP:0000831)2.34065840
64Hemorrhage of the eye (HP:0011885)2.31773094
65Abnormality of glycolysis (HP:0004366)2.30054693
66Increased variability in muscle fiber diameter (HP:0003557)2.29623370
67Bone cyst (HP:0012062)2.28125884
68Gout (HP:0001997)2.27464698
69Skin nodule (HP:0200036)2.24608632
70Abnormal tarsal ossification (HP:0008369)2.23595102
71Increased purine levels (HP:0004368)2.23023005
72Hyperuricemia (HP:0002149)2.23023005
73Polygenic inheritance (HP:0010982)2.20892755
74Dicarboxylic aciduria (HP:0003215)2.20521062
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20521062
76Alopecia of scalp (HP:0002293)2.20214999
77Vascular calcification (HP:0004934)2.19651487
78Sensorimotor neuropathy (HP:0007141)2.19567978
79Hepatocellular carcinoma (HP:0001402)2.19437458
80Delayed CNS myelination (HP:0002188)2.17895725
81Abdominal distention (HP:0003270)2.16304263
82Hyperglycemia (HP:0003074)2.14207279
83Neonatal hypoglycemia (HP:0001998)2.13312244
84Retinal atrophy (HP:0001105)2.12928266
85Late onset (HP:0003584)2.12423953
86Pustule (HP:0200039)2.10534554
87Abnormal cartilage morphology (HP:0002763)2.10325229
88Irritability (HP:0000737)2.10270785
89Pigmentary retinal degeneration (HP:0001146)2.10032325
90Ketoacidosis (HP:0001993)2.09708232
91Abnormal delivery (HP:0001787)2.08573701
92Abnormality of iron homeostasis (HP:0011031)2.07942061
93Menorrhagia (HP:0000132)2.07271836
94Joint swelling (HP:0001386)2.05310367
95Cholelithiasis (HP:0001081)2.05014083
96Hypophosphatemic rickets (HP:0004912)2.04185592
97Abnormal gallbladder morphology (HP:0012437)2.03607526
98Generalized aminoaciduria (HP:0002909)2.03369536
99Lethargy (HP:0001254)2.02179515
100Long foot (HP:0001833)2.01854277
101Spastic diplegia (HP:0001264)2.01735860
102Growth hormone excess (HP:0000845)2.00632028
103Hypochromic microcytic anemia (HP:0004840)2.00590338
104Mitral stenosis (HP:0001718)2.00134547
105Abnormality of transition element cation homeostasis (HP:0011030)2.00084430
106Ileus (HP:0002595)1.98821319
107Nephritis (HP:0000123)1.98764110
108Alkalosis (HP:0001948)1.98441313
109Axonal loss (HP:0003447)1.98315201
110Cardiovascular calcification (HP:0011915)1.97433513
111Cervical subluxation (HP:0003308)1.97233241
112Metaphyseal dysplasia (HP:0100255)1.93280601
113Back pain (HP:0003418)1.92027990
114Purpura (HP:0000979)1.91900268
115Abnormality of serum amino acid levels (HP:0003112)1.91137845
116Metabolic acidosis (HP:0001942)1.90831297
117Protuberant abdomen (HP:0001538)1.90766711
118Polycythemia (HP:0001901)1.90223128
119Neonatal onset (HP:0003623)1.89784953
120Lymphangioma (HP:0100764)1.88714996
121Atrioventricular block (HP:0001678)1.87989712
122Toxemia of pregnancy (HP:0100603)1.87739240
123Pancreatitis (HP:0001733)1.85876343
124Rickets (HP:0002748)1.85538142
125Congenital ichthyosiform erythroderma (HP:0007431)1.85198972
126Abnormal eating behavior (HP:0100738)1.81873054
127Abnormality of skeletal muscle fiber size (HP:0012084)1.81020648
128Reduced antithrombin III activity (HP:0001976)1.80934833
129Abnormal hemoglobin (HP:0011902)1.78196136
130Increased mean platelet volume (HP:0011877)1.76007340
131Reduced subcutaneous adipose tissue (HP:0003758)1.75071843
132Nausea (HP:0002018)1.74885343
133Vascular tortuosity (HP:0004948)1.74194493
134Subcapsular cataract (HP:0000523)1.73666594
135Abnormality of proline metabolism (HP:0010907)1.70292114
136Hydroxyprolinuria (HP:0003080)1.70292114
137Prominent supraorbital ridges (HP:0000336)1.69614244
138Ectopia lentis (HP:0001083)1.64013332
139Abnormality of carpal bone ossification (HP:0006257)1.63993427
140Muscle fiber splitting (HP:0003555)1.63389238
141Glomerulosclerosis (HP:0000096)1.62403496
142Aortic aneurysm (HP:0004942)1.61820627
143Striae distensae (HP:0001065)1.58045266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R8.27944709
2PIK3CA8.16316335
3MAP3K23.84738949
4KSR23.64257099
5TGFBR23.24769497
6MET3.07789596
7ERN13.06889272
8RIPK12.87335589
9TAOK32.74465327
10MAP2K22.72337431
11DDR22.65810169
12ARAF2.62565226
13FRK2.59062242
14FGFR42.27315802
15LATS22.22599471
16TIE12.16729505
17BCKDK2.13005337
18MAP3K131.99267970
19MOS1.90096279
20TRPM71.83321132
21GRK51.71698161
22ERBB41.71586242
23NME11.67237750
24MAP2K11.62615996
25MAPKAPK31.61770896
26MAP3K141.43515239
27MAP3K61.42864074
28PINK11.39537376
29MAP3K11.38651222
30PDGFRA1.37128012
31MAP3K91.34985206
32SIK11.26688946
33CAMK11.14881302
34ADRBK11.14844307
35EPHA31.10857504
36CAMK2D1.07175472
37MUSK1.06037856
38MAPK111.03652975
39EPHB11.00406229
40ILK0.98046179
41RET0.95190295
42GRK60.94836678
43PTK60.90900292
44JAK20.89919980
45NLK0.87073696
46TAOK10.84008016
47TBK10.82674848
48PTK20.82661043
49CAMK1D0.82387023
50CDK60.81471848
51INSRR0.81332257
52PIK3CG0.76930323
53MYLK0.76349625
54TRIB30.74054308
55EPHB20.73814988
56CAMKK20.71795284
57MAP3K30.70952893
58IRAK30.70369466
59PDGFRB0.69204629
60CDC42BPA0.64947155
61STK240.64558900
62MAP3K80.64407666
63ERBB20.63427957
64STK380.61851423
65MAPK70.61408690
66MAP2K40.60565950
67STK38L0.60424451
68PRKG10.58062815
69MAP2K30.57639961
70KDR0.57366467
71PIM20.56016982
72TYK20.55198894
73MAP3K110.54118045
74EEF2K0.52999581
75LRRK20.52210702
76MAP3K120.50268360
77NTRK10.50121986
78CAMK2G0.48115744
79CDK90.45881459
80DAPK20.45858779
81PDK10.44209779
82PAK40.43241788
83IKBKE0.42823751
84GRK10.42531013
85PKN20.42519624
86TAOK20.41946977
87PRKAA20.41639507
88ABL20.41232439
89ABL10.40738169
90JAK10.40360949
91MAP3K70.40136434
92LATS10.39751671
93IRAK10.39227904
94AKT20.37948818
95MTOR0.37835896
96MAPK150.36752324
97PRPF4B0.36594988
98MAPK40.35883847
99PRKG20.35800465
100MAPK30.34600000
101PRKCZ0.34187702
102RIPK40.34033418
103KIT0.32446018
104LMTK20.31760834
105BRAF0.31575890
106GRK70.31403012
107PRKD10.30108148
108PRKACG0.29426686
109CSK0.28854272
110EPHA20.28838956
111INSR0.27548410
112ACVR1B0.27287463
113PDK20.27245470
114MELK0.26945424
115MAPK120.25925572
116SRC0.24043632
117GSK3A0.23908664
118FGFR20.23391182
119IGF1R0.21940391
120FER0.21110809
121RPS6KB20.20498336
122PRKCA0.19456027
123PDPK10.18859833
124LYN0.17177479
125IRAK20.15296258
126NEK90.15075028
127FGFR30.14864780
128SGK4940.14789927
129SGK2230.14789927
130DAPK30.14735098
131SGK30.13491174
132PKN10.13148826
133PTK2B0.12301035
134CHUK0.12286433
135PAK20.11779893
136CAMK2B0.09876195
137CSNK1E0.08585276
138ITK0.08059122
139TESK10.07540171
140WNK10.07101788
141PRKCQ0.06107824
142PRKAA10.06103111
143PRKACB0.06075706
144BMX0.05716221
145STK110.04770107
146MAP2K60.04358217
147MAP3K100.04302651

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.19354227
2Complement and coagulation cascades_Homo sapiens_hsa046103.31424420
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26933344
4Arginine biosynthesis_Homo sapiens_hsa002202.97738506
5Nitrogen metabolism_Homo sapiens_hsa009102.97254907
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86951585
7Bile secretion_Homo sapiens_hsa049762.57978009
8Tryptophan metabolism_Homo sapiens_hsa003802.54427541
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.48248711
10Sulfur metabolism_Homo sapiens_hsa009202.42200350
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.32076385
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.28226583
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.24329458
14Caffeine metabolism_Homo sapiens_hsa002322.17849541
15Staphylococcus aureus infection_Homo sapiens_hsa051502.11963500
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10560251
17Fatty acid degradation_Homo sapiens_hsa000712.09441241
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.06551815
19PPAR signaling pathway_Homo sapiens_hsa033202.04012507
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.85592293
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84051298
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83768757
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83039225
24Histidine metabolism_Homo sapiens_hsa003401.79144549
25Butanoate metabolism_Homo sapiens_hsa006501.76968378
26Peroxisome_Homo sapiens_hsa041461.71951675
27Chemical carcinogenesis_Homo sapiens_hsa052041.69689082
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58959986
29Phenylalanine metabolism_Homo sapiens_hsa003601.53185386
30Fatty acid metabolism_Homo sapiens_hsa012121.49935255
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.49336046
32Propanoate metabolism_Homo sapiens_hsa006401.45365302
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39451891
34Fat digestion and absorption_Homo sapiens_hsa049751.33643897
35Retinol metabolism_Homo sapiens_hsa008301.28570305
36Tyrosine metabolism_Homo sapiens_hsa003501.28382493
37beta-Alanine metabolism_Homo sapiens_hsa004101.26534104
38Folate biosynthesis_Homo sapiens_hsa007901.26353247
39Selenocompound metabolism_Homo sapiens_hsa004501.25290101
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23206442
41Mineral absorption_Homo sapiens_hsa049781.21273114
42ABC transporters_Homo sapiens_hsa020101.20942400
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.17792954
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.14035140
45Pyruvate metabolism_Homo sapiens_hsa006201.11938876
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10879265
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10289877
48Starch and sucrose metabolism_Homo sapiens_hsa005001.08427013
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05355481
50Prion diseases_Homo sapiens_hsa050201.02291505
51Steroid biosynthesis_Homo sapiens_hsa001001.00887297
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00634699
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99790066
54Biosynthesis of amino acids_Homo sapiens_hsa012300.96550276
55Arachidonic acid metabolism_Homo sapiens_hsa005900.94140967
56Glycerolipid metabolism_Homo sapiens_hsa005610.92866319
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92269703
58Sulfur relay system_Homo sapiens_hsa041220.91205908
59Carbon metabolism_Homo sapiens_hsa012000.88735521
60AMPK signaling pathway_Homo sapiens_hsa041520.84870392
61Fatty acid elongation_Homo sapiens_hsa000620.83000076
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.78013216
63Vitamin digestion and absorption_Homo sapiens_hsa049770.76188981
64Arginine and proline metabolism_Homo sapiens_hsa003300.68206874
65Pentose phosphate pathway_Homo sapiens_hsa000300.65970947
66Fatty acid biosynthesis_Homo sapiens_hsa000610.63963021
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63681849
68Glutathione metabolism_Homo sapiens_hsa004800.58029910
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56386780
70ECM-receptor interaction_Homo sapiens_hsa045120.53946767
71Galactose metabolism_Homo sapiens_hsa000520.53510699
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40995888
73Metabolic pathways_Homo sapiens_hsa011000.38261917
74Hepatitis C_Homo sapiens_hsa051600.38249746
75Vitamin B6 metabolism_Homo sapiens_hsa007500.36683585
76Fructose and mannose metabolism_Homo sapiens_hsa000510.35519763
77Ovarian steroidogenesis_Homo sapiens_hsa049130.34273182
78Bladder cancer_Homo sapiens_hsa052190.33788199
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.32681049
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32582159
81Linoleic acid metabolism_Homo sapiens_hsa005910.30298590
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.25130328
83Thyroid cancer_Homo sapiens_hsa052160.24201084
84Lysine degradation_Homo sapiens_hsa003100.23966201
85Other glycan degradation_Homo sapiens_hsa005110.22629946
86Insulin resistance_Homo sapiens_hsa049310.19594875
87Pertussis_Homo sapiens_hsa051330.19323528
88Malaria_Homo sapiens_hsa051440.18026971
89Dorso-ventral axis formation_Homo sapiens_hsa043200.16454837
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16286639
91One carbon pool by folate_Homo sapiens_hsa006700.16085884
92African trypanosomiasis_Homo sapiens_hsa051430.12388625
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10239700
94Focal adhesion_Homo sapiens_hsa045100.10230887
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.08282110
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.07799277
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.07717610
98Salivary secretion_Homo sapiens_hsa049700.07268227
99Circadian rhythm_Homo sapiens_hsa047100.06471061
100Amoebiasis_Homo sapiens_hsa051460.05758703
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05081748
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.03997298
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.02773141
104Glucagon signaling pathway_Homo sapiens_hsa049220.02767218
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.02659371
106Type II diabetes mellitus_Homo sapiens_hsa049300.02498499
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.00565992
108Tight junction_Homo sapiens_hsa045300.00509564
109Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.0652174
110Renin secretion_Homo sapiens_hsa04924-0.0523692
111Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0491610
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0425026
113Renin-angiotensin system_Homo sapiens_hsa04614-0.0409672
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0302314
115Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0246831
116Insulin signaling pathway_Homo sapiens_hsa04910-0.0137422

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