SAA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.34486655
2omega-hydroxylase P450 pathway (GO:0097267)7.09242154
3epoxygenase P450 pathway (GO:0019373)6.91065872
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.79670874
5L-phenylalanine catabolic process (GO:0006559)6.79670874
6* acute-phase response (GO:0006953)6.75188972
7regulation of protein activation cascade (GO:2000257)6.68935683
8L-phenylalanine metabolic process (GO:0006558)6.56426715
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.56426715
10complement activation, alternative pathway (GO:0006957)6.37091738
11negative regulation of fibrinolysis (GO:0051918)6.36590870
12aromatic amino acid family catabolic process (GO:0009074)6.34417158
13indole-containing compound catabolic process (GO:0042436)6.15821669
14indolalkylamine catabolic process (GO:0046218)6.15821669
15tryptophan catabolic process (GO:0006569)6.15821669
16regulation of complement activation (GO:0030449)6.03917412
17positive regulation of heterotypic cell-cell adhesion (GO:0034116)6.01865486
18regulation of fibrinolysis (GO:0051917)6.00493535
19heme transport (GO:0015886)5.99813320
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.99094291
21kynurenine metabolic process (GO:0070189)5.96677985
22protein carboxylation (GO:0018214)5.85648373
23peptidyl-glutamic acid carboxylation (GO:0017187)5.85648373
24tryptophan metabolic process (GO:0006568)5.67980270
25high-density lipoprotein particle remodeling (GO:0034375)5.53860470
26ethanol oxidation (GO:0006069)5.49397345
27opsonization (GO:0008228)5.37585963
28bile acid biosynthetic process (GO:0006699)5.29135249
29negative regulation of protein activation cascade (GO:2000258)5.29064130
30glyoxylate metabolic process (GO:0046487)5.25600856
31urea cycle (GO:0000050)5.22906680
32urea metabolic process (GO:0019627)5.22906680
33regulation of cholesterol esterification (GO:0010872)5.22162118
34drug metabolic process (GO:0017144)5.09936167
35regulation of triglyceride catabolic process (GO:0010896)5.07348596
36alpha-linolenic acid metabolic process (GO:0036109)4.98039426
37phospholipid efflux (GO:0033700)4.85003574
38macromolecular complex remodeling (GO:0034367)4.77817265
39plasma lipoprotein particle remodeling (GO:0034369)4.77817265
40protein-lipid complex remodeling (GO:0034368)4.77817265
41nitrogen cycle metabolic process (GO:0071941)4.76243510
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.74809508
43reverse cholesterol transport (GO:0043691)4.70526762
44complement activation, classical pathway (GO:0006958)4.61566467
45fibrinolysis (GO:0042730)4.56417496
46aromatic amino acid family metabolic process (GO:0009072)4.54346455
47* acute inflammatory response (GO:0002526)4.48466330
48ethanol metabolic process (GO:0006067)4.46721863
49cysteine metabolic process (GO:0006534)4.46689513
50oxidative demethylation (GO:0070989)4.44326489
51negative regulation of cholesterol transport (GO:0032375)4.42004582
52negative regulation of sterol transport (GO:0032372)4.42004582
53cellular glucuronidation (GO:0052695)4.39421565
54bile acid metabolic process (GO:0008206)4.39157635
55complement activation (GO:0006956)4.38135842
56triglyceride homeostasis (GO:0070328)4.36655532
57acylglycerol homeostasis (GO:0055090)4.36655532
58sulfur amino acid catabolic process (GO:0000098)4.36528096
59serine family amino acid catabolic process (GO:0009071)4.35303203
60protein activation cascade (GO:0072376)4.34707653
61iron coordination entity transport (GO:1901678)4.34359810
62response to phenylpropanoid (GO:0080184)4.29438092
63triglyceride catabolic process (GO:0019433)4.27489877
64coenzyme catabolic process (GO:0009109)4.26543701
65plasma lipoprotein particle clearance (GO:0034381)4.25510076
66cholesterol efflux (GO:0033344)4.24909323
67indolalkylamine metabolic process (GO:0006586)4.21742176
68benzene-containing compound metabolic process (GO:0042537)4.19482888
69cellular biogenic amine catabolic process (GO:0042402)4.18396354
70amine catabolic process (GO:0009310)4.18396354
71tyrosine metabolic process (GO:0006570)4.16819519
72glucuronate metabolic process (GO:0019585)4.16632103
73uronic acid metabolic process (GO:0006063)4.16632103
74regulation of humoral immune response (GO:0002920)4.15118724
75disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.14280075
76killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.14280075
77lysine catabolic process (GO:0006554)4.12468445
78lysine metabolic process (GO:0006553)4.12468445
79cytolysis (GO:0019835)4.10202290
80regulation of plasminogen activation (GO:0010755)4.08806978
81plasma lipoprotein particle assembly (GO:0034377)4.04053012
82alpha-amino acid catabolic process (GO:1901606)4.02478578
83positive regulation of lipoprotein lipase activity (GO:0051006)3.99615132
84positive regulation of triglyceride lipase activity (GO:0061365)3.99615132
85negative regulation of complement activation (GO:0045916)3.98824441
86blood coagulation, intrinsic pathway (GO:0007597)3.97409226
87negative regulation of lipase activity (GO:0060192)3.93390101
88very-low-density lipoprotein particle assembly (GO:0034379)3.91393331
89acylglycerol catabolic process (GO:0046464)3.90598887
90neutral lipid catabolic process (GO:0046461)3.90598887
91homocysteine metabolic process (GO:0050667)3.83319610
92phenylpropanoid metabolic process (GO:0009698)3.80489829
93dicarboxylic acid biosynthetic process (GO:0043650)3.80454619
94cofactor catabolic process (GO:0051187)3.79658485
95positive regulation of lipid catabolic process (GO:0050996)3.79463245
96amino-acid betaine metabolic process (GO:0006577)3.78988483
97bile acid and bile salt transport (GO:0015721)3.76990579
98negative regulation of coagulation (GO:0050819)3.76985749
99glutamate metabolic process (GO:0006536)3.69712693
100regulation of cholesterol homeostasis (GO:2000188)3.69320032
101negative regulation of wound healing (GO:0061045)3.66830817
102S-adenosylmethionine metabolic process (GO:0046500)3.66763503
103arginine metabolic process (GO:0006525)3.64905856
104cellular amino acid catabolic process (GO:0009063)3.63872910
105regulation of acute inflammatory response (GO:0002673)3.63432326
106protein-lipid complex assembly (GO:0065005)3.63021284
107cellular modified amino acid catabolic process (GO:0042219)3.62054782
108drug catabolic process (GO:0042737)3.61461859
109plasma lipoprotein particle organization (GO:0071827)3.60549244
110glycine metabolic process (GO:0006544)3.56394580
111positive regulation of fatty acid beta-oxidation (GO:0032000)3.55582234
112low-density lipoprotein particle clearance (GO:0034383)3.54876100
113positive regulation of fatty acid biosynthetic process (GO:0045723)3.53637340
114regulation of apoptotic cell clearance (GO:2000425)3.51864153
115serine family amino acid metabolic process (GO:0009069)3.51291288
116imidazole-containing compound metabolic process (GO:0052803)3.49648562
117acetyl-CoA metabolic process (GO:0006084)3.47084084
118negative regulation of hemostasis (GO:1900047)3.45484874
119negative regulation of blood coagulation (GO:0030195)3.45484874
120disruption of cells of other organism (GO:0044364)3.45408544
121killing of cells of other organism (GO:0031640)3.45408544
122regulation of heterotypic cell-cell adhesion (GO:0034114)3.44931222
123flavonoid metabolic process (GO:0009812)3.44906239
124primary alcohol metabolic process (GO:0034308)3.43588530
125lipoprotein metabolic process (GO:0042157)3.42504592
126cholesterol homeostasis (GO:0042632)3.42008325
127primary alcohol catabolic process (GO:0034310)3.40348385
128oxaloacetate metabolic process (GO:0006107)3.29299741
129doxorubicin metabolic process (GO:0044598)3.26540271
130daunorubicin metabolic process (GO:0044597)3.26540271
131polyketide metabolic process (GO:0030638)3.26540271
132positive regulation of blood coagulation (GO:0030194)3.25161563
133positive regulation of hemostasis (GO:1900048)3.25161563
134intestinal cholesterol absorption (GO:0030299)3.22429063
135negative regulation of humoral immune response (GO:0002921)3.20853072
136arginine catabolic process (GO:0006527)3.17381101
137fatty acid homeostasis (GO:0055089)3.14674957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.74728315
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.74061925
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.73229256
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.01637568
5* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.48454062
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.33541496
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.03136229
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.39143874
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.35461749
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.04256469
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03833617
12* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7187876
13TP63_17297297_ChIP-ChIP_HaCaT_Human1.99883627
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93296014
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87701545
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.81762610
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80931708
18CLOCK_20551151_ChIP-Seq_293T_Human1.78731160
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67089200
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.61089162
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47646782
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45605457
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39724729
24HNF4A_19822575_ChIP-Seq_HepG2_Human1.33449512
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.26590132
26HTT_18923047_ChIP-ChIP_STHdh_Human1.22099578
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18717296
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.13109771
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11222740
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10822438
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09455136
32RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06553901
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04680489
34CJUN_26792858_Chip-Seq_BT549_Human1.02628654
35GATA1_22025678_ChIP-Seq_K562_Human1.00815659
36ESR1_21235772_ChIP-Seq_MCF-7_Human0.97254850
37SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96151819
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93417455
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93403688
40PIAS1_25552417_ChIP-Seq_VCAP_Human0.92325785
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90780624
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89917588
43GATA2_21666600_ChIP-Seq_HMVEC_Human0.87464518
44PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84898844
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83601659
46SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80898972
47* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80032895
48ZNF263_19887448_ChIP-Seq_K562_Human0.78881421
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77410144
50P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74371424
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72117385
52AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71631138
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71564001
54TP53_18474530_ChIP-ChIP_U2OS_Human0.70158266
55GATA4_25053715_ChIP-Seq_YYC3_Human0.69119185
56* GATA3_24758297_ChIP-Seq_MCF-7_Human0.68194447
57STAT3_1855785_ChIP-Seq_MESCs_Mouse0.67407806
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67354908
59CDX2_20551321_ChIP-Seq_CACO-2_Human0.67260625
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66329933
61NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66131515
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66131515
63SMC4_20622854_ChIP-Seq_HELA_Human0.65220597
64RARA_24833708_ChIP-Seq_LIVER_Mouse0.64957267
65TBX20_22328084_ChIP-Seq_HEART_Mouse0.63503130
66TBX20_22080862_ChIP-Seq_HEART_Mouse0.63503130
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.62474978
68SOX2_20726797_ChIP-Seq_SW620_Human0.62168175
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.62127330
70LXR_22292898_ChIP-Seq_THP-1_Human0.61767817
71P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.60105806
72FOXO3_23340844_ChIP-Seq_DLD1_Human0.60102657
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.59088865
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.58345100
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58219027
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57611921
77ZNF217_24962896_ChIP-Seq_MCF-7_Human0.57599567
78RAC3_21632823_ChIP-Seq_H3396_Human0.57187546
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.56799827
80TP63_23658742_ChIP-Seq_EP156T_Human0.56595250
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.55580495
82ERA_21632823_ChIP-Seq_H3396_Human0.55341119
83STAT6_21828071_ChIP-Seq_BEAS2B_Human0.54695058
84RAD21_21589869_ChIP-Seq_MESCs_Mouse0.54625366
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.54583019
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54464996
87BCAT_22108803_ChIP-Seq_LS180_Human0.53695905
88SOX2_21211035_ChIP-Seq_LN229_Human0.53020048
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52809034
90AHR_22903824_ChIP-Seq_MCF-7_Human0.52494871
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.51937298
92STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.51302673
93HNFA_21074721_ChIP-Seq_CACO-2_Human0.51195374
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.50990921
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50493903
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.50461576
97CEBPB_22108803_ChIP-Seq_LS180_Human0.49640331
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.49456613
99RARB_24833708_ChIP-Seq_LIVER_Mouse0.49087864
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.48993101
101FOXA1_25552417_ChIP-Seq_VCAP_Human0.48945376
102CBP_21632823_ChIP-Seq_H3396_Human0.47651017
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.47212969
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45520078
105AR_20517297_ChIP-Seq_VCAP_Human0.44743975
106KAP1_22055183_ChIP-Seq_ESCs_Mouse0.44706657
107GATA6_25053715_ChIP-Seq_YYC3_Human0.44421291
108NFIB_24661679_ChIP-Seq_LUNG_Mouse0.43813739
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.43520877
110P53_21459846_ChIP-Seq_SAOS-2_Human0.42446282
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42436340
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.42245322
113MYC_27129775_Chip-Seq_CORNEA_Mouse0.41846965
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.41212642
115GATA2_19941826_ChIP-Seq_K562_Human0.41155193
116FOXH1_21741376_ChIP-Seq_EPCs_Human0.40876487
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.40183106
118* MYC_19915707_ChIP-ChIP_AK7_Human0.40093571
119FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.40013746
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.39689143
121EGR1_19032775_ChIP-ChIP_M12_Human0.39301164
122RACK7_27058665_Chip-Seq_MCF-7_Human0.39033425
123GATA1_19941826_ChIP-Seq_K562_Human0.38771965
124AR_21572438_ChIP-Seq_LNCaP_Human0.38569047
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.38067120
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.37565041
127CDX2_22108803_ChIP-Seq_LS180_Human0.37461730
128TAF2_19829295_ChIP-Seq_ESCs_Human0.37178622
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.36499753
130IRF1_19129219_ChIP-ChIP_H3396_Human0.35767668
131CSB_26484114_Chip-Seq_FIBROBLAST_Human0.35114839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.00007470
2MP0005360_urolithiasis7.58562685
3MP0005085_abnormal_gallbladder_physiolo6.21539955
4MP0005365_abnormal_bile_salt5.85868522
5MP0008875_abnormal_xenobiotic_pharmacok4.42510300
6MP0003806_abnormal_nucleotide_metabolis4.05539483
7MP0010329_abnormal_lipoprotein_level3.52488640
8MP0003252_abnormal_bile_duct3.43102208
9MP0003191_abnormal_cellular_cholesterol3.35199248
10MP0009840_abnormal_foam_cell3.23548629
11MP0005083_abnormal_biliary_tract2.94602285
12MP0003195_calcinosis2.65332554
13MP0005332_abnormal_amino_acid2.64237777
14MP0001666_abnormal_nutrient_absorption2.50747266
15MP0000609_abnormal_liver_physiology2.17584358
16* MP0002118_abnormal_lipid_homeostasis2.07361843
17MP0004019_abnormal_vitamin_homeostasis1.92621880
18MP0002138_abnormal_hepatobiliary_system1.91313583
19MP0005319_abnormal_enzyme/_coenzyme1.78332474
20MP0003011_delayed_dark_adaptation1.74921560
21MP0005375_adipose_tissue_phenotype1.74280340
22MP0000604_amyloidosis1.61853504
23MP0005584_abnormal_enzyme/coenzyme_acti1.53459062
24MP0003705_abnormal_hypodermis_morpholog1.41876990
25MP0001764_abnormal_homeostasis1.39754180
26MP0003868_abnormal_feces_composition1.38748925
27MP0002254_reproductive_system_inflammat1.37755212
28MP0009643_abnormal_urine_homeostasis1.32907958
29MP0009764_decreased_sensitivity_to1.31048330
30MP0009697_abnormal_copulation1.30366201
31MP0001881_abnormal_mammary_gland1.25412898
32MP0009763_increased_sensitivity_to1.23721734
33MP0005636_abnormal_mineral_homeostasis1.19685010
34MP0003656_abnormal_erythrocyte_physiolo1.16339675
35MP0002132_abnormal_respiratory_system1.14898009
36MP0005670_abnormal_white_adipose1.13873104
37MP0010368_abnormal_lymphatic_system1.13061702
38MP0000598_abnormal_liver_morphology1.12819983
39MP0008469_abnormal_protein_level1.11960680
40MP0005647_abnormal_sex_gland1.08083481
41MP0003690_abnormal_glial_cell1.00054618
42MP0003959_abnormal_lean_body0.98713184
43MP0000003_abnormal_adipose_tissue0.96852637
44* MP0009642_abnormal_blood_homeostasis0.94190609
45MP0003950_abnormal_plasma_membrane0.92614213
46MP0003186_abnormal_redox_activity0.91647807
47MP0009379_abnormal_foot_pigmentation0.89041891
48MP0005464_abnormal_platelet_physiology0.86909280
49MP0004272_abnormal_basement_membrane0.85589266
50MP0004185_abnormal_adipocyte_glucose0.83948223
51MP0002971_abnormal_brown_adipose0.81862665
52MP0000579_abnormal_nail_morphology0.81328986
53MP0009765_abnormal_xenobiotic_induced0.81249618
54MP0009053_abnormal_anal_canal0.80378869
55MP0009384_cardiac_valve_regurgitation0.79864081
56MP0010234_abnormal_vibrissa_follicle0.77850308
57MP0005220_abnormal_exocrine_pancreas0.75694645
58MP0003724_increased_susceptibility_to0.74346895
59MP0005084_abnormal_gallbladder_morpholo0.74067525
60MP0002282_abnormal_trachea_morphology0.74051523
61MP0003329_amyloid_beta_deposits0.72805297
62MP0005376_homeostasis/metabolism_phenot0.71981592
63MP0004264_abnormal_extraembryonic_tissu0.69895899
64MP0005451_abnormal_body_composition0.69802995
65MP0002078_abnormal_glucose_homeostasis0.69748668
66MP0005334_abnormal_fat_pad0.69469075
67MP0003879_abnormal_hair_cell0.69206168
68MP0005023_abnormal_wound_healing0.69140030
69MP0005408_hypopigmentation0.69106735
70MP0004130_abnormal_muscle_cell0.68466488
71MP0005395_other_phenotype0.67460507
72MP0005166_decreased_susceptibility_to0.67419657
73MP0003436_decreased_susceptibility_to0.65830105
74MP0000639_abnormal_adrenal_gland0.65772488
75MP0006138_congestive_heart_failure0.65274669
76MP0002909_abnormal_adrenal_gland0.64770152
77MP0001879_abnormal_lymphatic_vessel0.64629465
78MP0002876_abnormal_thyroid_physiology0.62288649
79MP0006036_abnormal_mitochondrial_physio0.62180113
80MP0005452_abnormal_adipose_tissue0.61627394
81MP0005535_abnormal_body_temperature0.58041369
82MP0003075_altered_response_to0.57937761
83MP0005666_abnormal_adipose_tissue0.57407252
84MP0008872_abnormal_physiological_respon0.57331846
85MP0002136_abnormal_kidney_physiology0.56789019
86MP0004043_abnormal_pH_regulation0.55097478
87MP0008873_increased_physiological_sensi0.54415985
88MP0009780_abnormal_chondrocyte_physiolo0.53384289
89MP0002796_impaired_skin_barrier0.53249367
90MP0005503_abnormal_tendon_morphology0.52336071
91MP0002295_abnormal_pulmonary_circulatio0.52129350
92MP0008438_abnormal_cutaneous_collagen0.51910041
93MP0001756_abnormal_urination0.49334987
94MP0002108_abnormal_muscle_morphology0.48777556
95MP0001661_extended_life_span0.48602266
96MP0008874_decreased_physiological_sensi0.48470341
97MP0005595_abnormal_vascular_smooth0.48145884
98MP0000858_altered_metastatic_potential0.47646832
99MP0002249_abnormal_larynx_morphology0.47294097
100MP0005275_abnormal_skin_tensile0.47048695
101MP0003638_abnormal_response/metabolism_0.46754475
102MP0002332_abnormal_exercise_endurance0.46485848
103MP0000013_abnormal_adipose_tissue0.46138887
104MP0005266_abnormal_metabolism0.46069354
105MP0003828_pulmonary_edema0.45907118
106MP0005448_abnormal_energy_balance0.43445742
107MP0002168_other_aberrant_phenotype0.43187014
108MP0001944_abnormal_pancreas_morphology0.43138097
109MP0003453_abnormal_keratinocyte_physiol0.43060708
110MP0003303_peritoneal_inflammation0.41961031
111MP0009785_altered_susceptibility_to0.40851050
112MP0003300_gastrointestinal_ulcer0.40506512
113MP0001845_abnormal_inflammatory_respons0.39741490
114MP0005164_abnormal_response_to0.39706085
115MP0000427_abnormal_hair_cycle0.38373402
116MP0002135_abnormal_kidney_morphology0.37786544
117MP0006082_CNS_inflammation0.36001078
118MP0000249_abnormal_blood_vessel0.34704064
119MP0009115_abnormal_fat_cell0.34526806
120MP0003953_abnormal_hormone_level0.33715106
121MP0002060_abnormal_skin_morphology0.31643444
122MP0002970_abnormal_white_adipose0.31626695
123MP0006035_abnormal_mitochondrial_morpho0.31475986
124MP0005248_abnormal_Harderian_gland0.30370562
125MP0003718_maternal_effect0.30136064
126MP0000467_abnormal_esophagus_morphology0.28336767
127MP0004883_abnormal_blood_vessel0.28311062
128MP0003633_abnormal_nervous_system0.27114538

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.43902763
2Complement deficiency (HP:0004431)7.22367370
3Prolonged partial thromboplastin time (HP:0003645)6.95066624
4Intrahepatic cholestasis (HP:0001406)6.61589729
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.50986821
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.34585471
7Abnormality of the common coagulation pathway (HP:0010990)6.32440184
8Spontaneous abortion (HP:0005268)6.32270821
9Xanthomatosis (HP:0000991)5.79985052
10Hypobetalipoproteinemia (HP:0003563)5.59016227
11Hyperlipoproteinemia (HP:0010980)5.58317948
12Abnormality of complement system (HP:0005339)5.29527884
13Joint hemorrhage (HP:0005261)5.19236602
14Hypolipoproteinemia (HP:0010981)4.40994571
15Epidermoid cyst (HP:0200040)4.26025366
16Abnormality of the intrinsic pathway (HP:0010989)4.18548218
17Hypoalphalipoproteinemia (HP:0003233)4.12733753
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.11666384
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.04662263
20Hyperammonemia (HP:0001987)4.00678999
21Gingival bleeding (HP:0000225)3.98510427
22Fat malabsorption (HP:0002630)3.93868977
23Amyloidosis (HP:0011034)3.83137939
24Hyperglycinemia (HP:0002154)3.80991809
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.80644012
26Ketosis (HP:0001946)3.75605699
27Abnormality of methionine metabolism (HP:0010901)3.71463009
28Hypoglycemic coma (HP:0001325)3.71071451
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.68935407
30Systemic lupus erythematosus (HP:0002725)3.63728207
31Abnormality of pyrimidine metabolism (HP:0004353)3.51040744
32Conjugated hyperbilirubinemia (HP:0002908)3.30863612
33Recurrent gram-negative bacterial infections (HP:0005420)3.24502051
34Hypercholesterolemia (HP:0003124)3.23449648
35Myocardial infarction (HP:0001658)3.17594658
36Abnormality of glycine metabolism (HP:0010895)3.15934625
37Abnormality of serine family amino acid metabolism (HP:0010894)3.15934625
38Hyperglycinuria (HP:0003108)3.05587771
39Steatorrhea (HP:0002570)3.04571555
40Thrombophlebitis (HP:0004418)3.01767191
41Glomerulonephritis (HP:0000099)3.00396285
42Abnormality of nucleobase metabolism (HP:0010932)2.97648273
43Abnormality of iron homeostasis (HP:0011031)2.95019610
44Ketoacidosis (HP:0001993)2.82058323
45Hyperbilirubinemia (HP:0002904)2.81895091
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.79044968
47Abnormality of transition element cation homeostasis (HP:0011030)2.77348190
48Abnormality of fatty-acid metabolism (HP:0004359)2.75513194
49Abnormality of purine metabolism (HP:0004352)2.70952037
50Skin nodule (HP:0200036)2.70288291
51Hypochromic microcytic anemia (HP:0004840)2.65853053
52Hypoglycemic seizures (HP:0002173)2.61765342
53Mitral stenosis (HP:0001718)2.57827329
54Hepatocellular carcinoma (HP:0001402)2.54403747
55Spastic diplegia (HP:0001264)2.53226003
56Joint swelling (HP:0001386)2.51470253
57Vascular calcification (HP:0004934)2.51054627
58Late onset (HP:0003584)2.47889877
59Abnormality of serum amino acid levels (HP:0003112)2.45371449
60Oligomenorrhea (HP:0000876)2.39394397
61Cholecystitis (HP:0001082)2.39192844
62Abnormal gallbladder physiology (HP:0012438)2.39192844
63Nephritis (HP:0000123)2.38887746
64Acanthosis nigricans (HP:0000956)2.38126190
65Delayed CNS myelination (HP:0002188)2.33671134
66Increased serum pyruvate (HP:0003542)2.33663097
67Menorrhagia (HP:0000132)2.31811941
68Cholelithiasis (HP:0001081)2.30892574
69Lethargy (HP:0001254)2.29370042
70Abnormal gallbladder morphology (HP:0012437)2.28002239
71Gout (HP:0001997)2.25891752
72Cardiovascular calcification (HP:0011915)2.25187189
73Generalized aminoaciduria (HP:0002909)2.24848743
74Metabolic acidosis (HP:0001942)2.23323748
75Irritability (HP:0000737)2.22533736
76Hyperinsulinemic hypoglycemia (HP:0000825)2.20751130
77Esophageal varix (HP:0002040)2.19002402
78Abnormal delivery (HP:0001787)2.17632891
79Neonatal onset (HP:0003623)2.14971896
80Purpura (HP:0000979)2.14584063
81Sensorimotor neuropathy (HP:0007141)2.12873090
82Reduced antithrombin III activity (HP:0001976)2.10223537
83Malnutrition (HP:0004395)2.09896737
84Epistaxis (HP:0000421)2.06869221
85Abnormality of proline metabolism (HP:0010907)2.02146580
86Hydroxyprolinuria (HP:0003080)2.02146580
87Cerebral edema (HP:0002181)1.99972425
88Neonatal hypoglycemia (HP:0001998)1.98986670
89Abnormality of glycolysis (HP:0004366)1.98284286
90Opisthotonus (HP:0002179)1.96742498
91Hemorrhage of the eye (HP:0011885)1.96222380
92Hyperglycemia (HP:0003074)1.94321437
93Dicarboxylic aciduria (HP:0003215)1.89188801
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89188801
95Pancreatitis (HP:0001733)1.88283378
96Back pain (HP:0003418)1.87238936
97Retinal atrophy (HP:0001105)1.86347132
98Increased serum ferritin (HP:0003281)1.85632426
99Brushfield spots (HP:0001088)1.85512119
100Vomiting (HP:0002013)1.85374102
101Abnormality of the gallbladder (HP:0005264)1.84831519
102Acanthocytosis (HP:0001927)1.82940662
103Cerebral palsy (HP:0100021)1.81638503
104Hypophosphatemic rickets (HP:0004912)1.80517720
105Symptomatic seizures (HP:0011145)1.78931441
106Status epilepticus (HP:0002133)1.78785364
107Rickets (HP:0002748)1.76292373
108Spastic paraparesis (HP:0002313)1.74129405
109Atrioventricular block (HP:0001678)1.71787362
110Enlarged kidneys (HP:0000105)1.69613077
111Abnormality of endocrine pancreas physiology (HP:0012093)1.68631008
112Abnormality of the pancreatic islet cells (HP:0006476)1.68631008
113Axonal loss (HP:0003447)1.66571836
114Hypertriglyceridemia (HP:0002155)1.66360542
115Abnormal enzyme/coenzyme activity (HP:0012379)1.64009643
116Elevated alkaline phosphatase (HP:0003155)1.63328892
117Pulmonary embolism (HP:0002204)1.60385424
118Hyperphosphaturia (HP:0003109)1.59087378
119Osteomalacia (HP:0002749)1.57968659
120Insulin resistance (HP:0000855)1.56642207
121Abnormality of alkaline phosphatase activity (HP:0004379)1.56353120
122Fair hair (HP:0002286)1.49166324
123Abnormal platelet function (HP:0011869)1.47703417
124Impaired platelet aggregation (HP:0003540)1.47703417
125Glycosuria (HP:0003076)1.47175279
126Abnormality of urine glucose concentration (HP:0011016)1.47175279
127Abnormality of vitamin metabolism (HP:0100508)1.46291747
128Pigmentary retinal degeneration (HP:0001146)1.46157492
129Hyperalaninemia (HP:0003348)1.46108833
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.46108833
131Abnormality of alanine metabolism (HP:0010916)1.46108833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.85841892
2BCKDK5.24397025
3FGFR44.96886980
4ERBB43.74437425
5SIK13.31542361
6TAOK33.00259065
7LMTK22.73544340
8DAPK22.62246765
9PINK12.49852218
10EPHA32.47147766
11EPHB12.33012387
12TRIB32.28348997
13ARAF2.26755269
14MAPKAPK32.21204929
15MST1R2.15995040
16INSRR2.13367132
17PTK62.01152303
18MAP2K41.99446113
19MAPK111.89161727
20MYLK1.82520338
21PIK3CG1.76106343
22TYK21.68944822
23PIK3CA1.66863258
24EPHB21.66072079
25MOS1.62935842
26RIPK11.55005493
27LATS11.52758173
28TRPM71.48556225
29JAK21.46772221
30NEK91.44152645
31ERBB21.34323381
32ADRBK11.28630548
33PKN21.27603936
34GRK51.26045755
35CAMKK21.23214196
36JAK11.19668098
37DDR21.19440230
38EEF2K1.17487553
39MAP3K71.10715789
40FRK1.10019452
41TESK11.09343799
42GRK61.08131497
43STK391.05681662
44ABL21.03453263
45TBK11.02156637
46MET1.00341785
47CAMK2G0.94831189
48GRK10.94742394
49MAP3K90.92691311
50STK380.92639405
51CAMK1D0.91855172
52TNK20.91367696
53MAP3K140.89805588
54MAP3K110.88495894
55MST40.86273763
56PKN10.82821496
57MAP3K120.82620313
58FLT30.80378580
59BRSK20.79704320
60PRKAA20.78212988
61FGFR20.77029121
62MAP3K30.73935685
63GRK70.73620225
64MAP2K10.73002616
65MAPK40.72624127
66FGFR30.72598261
67PRKCZ0.71841512
68MAPK120.71392481
69PRKACG0.67768690
70KDR0.66648865
71MAP2K30.65987246
72EPHA20.64460381
73PRKG10.63056656
74RET0.62190078
75OBSCN0.59377617
76PTK20.58946904
77GSK3A0.58469966
78MAP3K10.58179513
79FER0.57434680
80MAPK150.56213451
81CAMK1G0.53000794
82DYRK1B0.52881009
83BMX0.52822708
84HIPK20.52336161
85IRAK10.51693543
86CDK60.50707094
87PIM20.49289121
88CSK0.48957705
89LATS20.48214589
90NLK0.47368593
91EGFR0.47050420
92PDPK10.46997111
93PHKG10.45273317
94PHKG20.45273317
95IRAK30.44989888
96EPHA40.44786862
97PAK30.43009792
98TGFBR20.41531543
99CAMK10.41123155
100MTOR0.40699131
101IGF1R0.39962268
102PRKCE0.38448035
103CSF1R0.37562869
104IKBKE0.37305961
105MAP3K130.37253509
106NTRK10.36474543
107PRKACA0.36233912
108ILK0.36232511
109PRKCG0.35076139
110MAP3K100.34970432
111PRKAA10.34909803
112SGK30.33980366
113EIF2AK20.33167803
114MAP3K60.33038830
115CDC42BPA0.32951166
116MAPKAPK50.32393947
117ERBB30.32286042
118DAPK30.32259932
119MUSK0.32055753
120MAP2K60.31832416
121STK38L0.31350347
122ICK0.31044528
123PRKACB0.30421854
124NTRK30.30228747
125MAPK70.29422880
126ABL10.29391939
127BCR0.29120833
128PDGFRA0.28380514
129SGK2230.28138934
130SGK4940.28138934
131CAMK40.26589478
132KIT0.26443548
133TIE10.25747681
134PDK10.24589110
135DAPK10.23891333
136MAP3K50.23664014
137MAP3K20.23340275
138PRKCQ0.23000374
139KSR20.22603867
140CSNK1G10.22585641
141PRKCA0.22468729
142PRKCH0.20582360

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.71200156
2Complement and coagulation cascades_Homo sapiens_hsa046103.86841823
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.59317670
4Arginine biosynthesis_Homo sapiens_hsa002203.13921824
5Nitrogen metabolism_Homo sapiens_hsa009103.13573799
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.85035654
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.61152047
8Tryptophan metabolism_Homo sapiens_hsa003802.58881562
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.51135997
10Staphylococcus aureus infection_Homo sapiens_hsa051502.48127869
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45837630
12Caffeine metabolism_Homo sapiens_hsa002322.28302891
13Fatty acid degradation_Homo sapiens_hsa000712.23806848
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08974464
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08344373
16Peroxisome_Homo sapiens_hsa041462.07770907
17PPAR signaling pathway_Homo sapiens_hsa033201.95034013
18Chemical carcinogenesis_Homo sapiens_hsa052041.93354602
19Butanoate metabolism_Homo sapiens_hsa006501.86296583
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81560657
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.79247712
22Histidine metabolism_Homo sapiens_hsa003401.74498821
23Propanoate metabolism_Homo sapiens_hsa006401.72546763
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.67194034
25Fatty acid metabolism_Homo sapiens_hsa012121.64634924
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64292355
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64015711
28Phenylalanine metabolism_Homo sapiens_hsa003601.56420235
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.53224238
30Bile secretion_Homo sapiens_hsa049761.50129042
31Selenocompound metabolism_Homo sapiens_hsa004501.47321575
32beta-Alanine metabolism_Homo sapiens_hsa004101.43976087
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43601705
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41804531
35Tyrosine metabolism_Homo sapiens_hsa003501.40383585
36Folate biosynthesis_Homo sapiens_hsa007901.39167134
37Retinol metabolism_Homo sapiens_hsa008301.37478093
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.37150997
39Fat digestion and absorption_Homo sapiens_hsa049751.32980350
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.29352396
41Pyruvate metabolism_Homo sapiens_hsa006201.27986074
42Steroid biosynthesis_Homo sapiens_hsa001001.27723678
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24681104
44Arachidonic acid metabolism_Homo sapiens_hsa005901.24203174
45Biosynthesis of amino acids_Homo sapiens_hsa012301.21005751
46Sulfur metabolism_Homo sapiens_hsa009201.17773913
47ABC transporters_Homo sapiens_hsa020101.14853685
48Starch and sucrose metabolism_Homo sapiens_hsa005001.13790604
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.10895866
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09373104
51Carbon metabolism_Homo sapiens_hsa012001.06411250
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05853280
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99402596
54Sulfur relay system_Homo sapiens_hsa041220.95427548
55Vitamin digestion and absorption_Homo sapiens_hsa049770.93684092
56Fatty acid elongation_Homo sapiens_hsa000620.93675045
57Vitamin B6 metabolism_Homo sapiens_hsa007500.92575572
58Arginine and proline metabolism_Homo sapiens_hsa003300.87478849
59Fatty acid biosynthesis_Homo sapiens_hsa000610.85611789
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84895387
61Glutathione metabolism_Homo sapiens_hsa004800.82904234
62Prion diseases_Homo sapiens_hsa050200.82632952
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79472713
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70090730
65Pentose phosphate pathway_Homo sapiens_hsa000300.67902994
66Lysine degradation_Homo sapiens_hsa003100.63954355
67Glycerolipid metabolism_Homo sapiens_hsa005610.57517777
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52465422
69One carbon pool by folate_Homo sapiens_hsa006700.51126695
70Mineral absorption_Homo sapiens_hsa049780.46232639
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40851222
72Metabolic pathways_Homo sapiens_hsa011000.39305883
73Galactose metabolism_Homo sapiens_hsa000520.38463133
74Fructose and mannose metabolism_Homo sapiens_hsa000510.31391643
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.30218169
76Insulin resistance_Homo sapiens_hsa049310.30205298
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19763875
78Glucagon signaling pathway_Homo sapiens_hsa049220.16977987
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.14188234
80Circadian rhythm_Homo sapiens_hsa047100.08795527
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07493408
82Linoleic acid metabolism_Homo sapiens_hsa005910.04613219
83Bladder cancer_Homo sapiens_hsa052190.04309845
84AMPK signaling pathway_Homo sapiens_hsa041520.03648772
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03448943
86Hepatitis C_Homo sapiens_hsa051600.02585617
87Renin-angiotensin system_Homo sapiens_hsa04614-0.2331559
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.2111662
89Dorso-ventral axis formation_Homo sapiens_hsa04320-0.2063421
90Type II diabetes mellitus_Homo sapiens_hsa04930-0.2027563
91Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1947511
92Prolactin signaling pathway_Homo sapiens_hsa04917-0.1922289
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.1594989
94Sphingolipid metabolism_Homo sapiens_hsa00600-0.1501927
95Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1318785
96Other glycan degradation_Homo sapiens_hsa00511-0.1263564
97Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1216088
98Serotonergic synapse_Homo sapiens_hsa04726-0.1112415
99Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0900781
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0887766
101Pertussis_Homo sapiens_hsa05133-0.0883032
102Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0782585
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0762777
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0687421
105Insulin signaling pathway_Homo sapiens_hsa04910-0.0671978
106African trypanosomiasis_Homo sapiens_hsa05143-0.0651742
107Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0369369
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0170645
109ECM-receptor interaction_Homo sapiens_hsa04512-0.0134790
110Amoebiasis_Homo sapiens_hsa05146-0.0113955

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