SAA2-SAA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring serum amyloid A2 and serum amyloid A4 genes on chromosome 11. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, alternative pathway (GO:0006957)9.19374655
2regulation of protein activation cascade (GO:2000257)8.51394831
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)8.38890675
4L-phenylalanine catabolic process (GO:0006559)8.38890675
5exogenous drug catabolic process (GO:0042738)8.36123412
6omega-hydroxylase P450 pathway (GO:0097267)8.33734267
7epoxygenase P450 pathway (GO:0019373)8.19264836
8drug catabolic process (GO:0042737)8.16143923
9regulation of complement activation (GO:0030449)8.00330913
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.77218757
11L-phenylalanine metabolic process (GO:0006558)7.77218757
12glyoxylate metabolic process (GO:0046487)7.30204421
13opsonization (GO:0008228)6.93542485
14regulation of fibrinolysis (GO:0051917)6.85180360
15negative regulation of fibrinolysis (GO:0051918)6.74751518
16protein carboxylation (GO:0018214)6.44861778
17peptidyl-glutamic acid carboxylation (GO:0017187)6.44861778
18acute-phase response (GO:0006953)6.34329330
19ethanol oxidation (GO:0006069)6.08236688
20aromatic amino acid family catabolic process (GO:0009074)6.04542696
21drug metabolic process (GO:0017144)5.96678629
22urea metabolic process (GO:0019627)5.90453064
23oxidative demethylation (GO:0070989)5.85701116
24serine family amino acid catabolic process (GO:0009071)5.81364256
25complement activation (GO:0006956)5.66165616
26fibrinolysis (GO:0042730)5.62364436
27bile acid biosynthetic process (GO:0006699)5.59824374
28complement activation, classical pathway (GO:0006958)5.59248971
29protein activation cascade (GO:0072376)5.59183853
30blood coagulation, intrinsic pathway (GO:0007597)5.46930179
31cellular glucuronidation (GO:0052695)5.43588990
32nitrogen cycle metabolic process (GO:0071941)5.36973863
33regulation of triglyceride catabolic process (GO:0010896)5.21195679
34cytolysis (GO:0019835)5.19294179
35glycine metabolic process (GO:0006544)5.18861059
36negative regulation of protein activation cascade (GO:2000258)5.18211685
37uronic acid metabolic process (GO:0006063)5.16207498
38glucuronate metabolic process (GO:0019585)5.16207498
39bile acid metabolic process (GO:0008206)5.14812481
40regulation of humoral immune response (GO:0002920)5.13801467
41ethanol metabolic process (GO:0006067)5.09631335
42S-adenosylmethionine metabolic process (GO:0046500)5.04337697
43tyrosine metabolic process (GO:0006570)5.03047168
44phenylpropanoid metabolic process (GO:0009698)5.00512882
45positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.97576655
46disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.91997451
47killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.91997451
48urea cycle (GO:0000050)4.90585789
49regulation of plasminogen activation (GO:0010755)4.79803913
50acute inflammatory response (GO:0002526)4.57369867
51negative regulation of sterol transport (GO:0032372)4.46487664
52negative regulation of cholesterol transport (GO:0032375)4.46487664
53amino-acid betaine metabolic process (GO:0006577)4.40448385
54response to mercury ion (GO:0046689)4.39058952
55bile acid and bile salt transport (GO:0015721)4.30646441
56negative regulation of hemostasis (GO:1900047)4.28242246
57negative regulation of blood coagulation (GO:0030195)4.28242246
58acylglycerol homeostasis (GO:0055090)4.18810622
59triglyceride homeostasis (GO:0070328)4.18810622
60imidazole-containing compound metabolic process (GO:0052803)4.15720071
61hormone catabolic process (GO:0042447)4.11567510
62triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.05989647
63negative regulation of complement activation (GO:0045916)4.03018846
64serine family amino acid metabolic process (GO:0009069)4.00323604
65aromatic amino acid family metabolic process (GO:0009072)3.97920254
66tryptophan catabolic process (GO:0006569)3.96233382
67indole-containing compound catabolic process (GO:0042436)3.96233382
68indolalkylamine catabolic process (GO:0046218)3.96233382
69negative regulation of wound healing (GO:0061045)3.95919928
70negative regulation of coagulation (GO:0050819)3.93488648
71glutamate metabolic process (GO:0006536)3.90914705
72positive regulation of lipoprotein lipase activity (GO:0051006)3.90520186
73positive regulation of triglyceride lipase activity (GO:0061365)3.90520186
74flavonoid metabolic process (GO:0009812)3.89227469
75regulation of apoptotic cell clearance (GO:2000425)3.84012241
76alpha-amino acid catabolic process (GO:1901606)3.77478293
77intestinal cholesterol absorption (GO:0030299)3.75973171
78protein-lipid complex remodeling (GO:0034368)3.62061258
79macromolecular complex remodeling (GO:0034367)3.62061258
80plasma lipoprotein particle remodeling (GO:0034369)3.62061258
81regulation of acute inflammatory response (GO:0002673)3.61629826
82primary alcohol catabolic process (GO:0034310)3.60765438
83xenobiotic metabolic process (GO:0006805)3.52958896
84negative regulation of lipase activity (GO:0060192)3.48862670
85cholesterol efflux (GO:0033344)3.48763893
86coenzyme catabolic process (GO:0009109)3.48179984
87alkaloid metabolic process (GO:0009820)3.47294156
88arginine metabolic process (GO:0006525)3.43170061
89positive regulation of blood coagulation (GO:0030194)3.42487426
90positive regulation of hemostasis (GO:1900048)3.42487426
91tryptophan metabolic process (GO:0006568)3.42162047
92negative regulation of humoral immune response (GO:0002921)3.34009012
93heme transport (GO:0015886)3.33228547
94xenobiotic catabolic process (GO:0042178)3.27073268
95cofactor catabolic process (GO:0051187)3.26743052
96oxaloacetate metabolic process (GO:0006107)3.26611761
97cellular amino acid catabolic process (GO:0009063)3.25327934
98daunorubicin metabolic process (GO:0044597)3.24620825
99polyketide metabolic process (GO:0030638)3.24620825
100doxorubicin metabolic process (GO:0044598)3.24620825

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse6.73786597
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.46611056
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.33319712
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.28965552
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.22939518
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.00081626
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.92716833
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.58600214
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.48016642
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.39523153
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15827364
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8698413
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95577879
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.90180651
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.76339100
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.73694914
17HNF4A_19822575_ChIP-Seq_HepG2_Human1.72811479
18HTT_18923047_ChIP-ChIP_STHdh_Human1.71589703
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65131649
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52318440
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31767792
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30619268
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19023979
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15842217
25BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14769957
26AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09457211
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06754234
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06415936
29CBP_21632823_ChIP-Seq_H3396_Human1.05889601
30PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05601162
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04301242
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03925394
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.02175449
34IRF8_22096565_ChIP-ChIP_GC-B_Human0.95644842
35GATA1_22025678_ChIP-Seq_K562_Human0.94950599
36HNFA_21074721_ChIP-Seq_CACO-2_Human0.94657595
37ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94625929
38CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94440404
39SOX2_20726797_ChIP-Seq_SW620_Human0.92313610
40CLOCK_20551151_ChIP-Seq_293T_Human0.91269756
41BCAT_22108803_ChIP-Seq_LS180_Human0.88865342
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86940243
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85156688
44GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83087961
45GATA4_25053715_ChIP-Seq_YYC3_Human0.82962153
46PHF8_20622853_ChIP-Seq_HELA_Human0.82818241
47TP53_18474530_ChIP-ChIP_U2OS_Human0.80985528
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80352417
49PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76586897
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.73510912
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72940202
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72557032
53GATA6_21074721_ChIP-Seq_CACO-2_Human0.71825543
54PIAS1_25552417_ChIP-Seq_VCAP_Human0.71338044
55NFYA_21822215_ChIP-Seq_K562_Human0.70731412
56CEBPB_22108803_ChIP-Seq_LS180_Human0.70505959
57RXRA_24833708_ChIP-Seq_LIVER_Mouse0.70296177
58RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69010288
59KAP1_22055183_ChIP-Seq_ESCs_Mouse0.68796652
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.68647864
61SPI1_20517297_ChIP-Seq_HL60_Human0.68630365
62ER_23166858_ChIP-Seq_MCF-7_Human0.67364953
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.65584975
64SMC4_20622854_ChIP-Seq_HELA_Human0.63780668
65SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62027406
66FOXA1_25552417_ChIP-Seq_VCAP_Human0.61417602
67AR_20517297_ChIP-Seq_VCAP_Human0.60940444
68RAC3_21632823_ChIP-Seq_H3396_Human0.60242186
69GATA6_25053715_ChIP-Seq_YYC3_Human0.59143954
70SOX2_21211035_ChIP-Seq_LN229_Human0.58514471
71SOX2_27498859_Chip-Seq_STOMACH_Mouse0.58212405
72CJUN_26792858_Chip-Seq_BT549_Human0.58026381
73CSB_26484114_Chip-Seq_FIBROBLAST_Human0.57643063
74CDX2_22108803_ChIP-Seq_LS180_Human0.56609996
75NFYB_21822215_ChIP-Seq_K562_Human0.56333085
76ETV1_20927104_ChIP-Seq_GIST48_Human0.56078069
77GATA3_24758297_ChIP-Seq_MCF-7_Human0.55641309
78BP1_19119308_ChIP-ChIP_Hs578T_Human0.55431841
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.55257401
80LXR_22292898_ChIP-Seq_THP-1_Human0.54762178
81CDX2_20551321_ChIP-Seq_CACO-2_Human0.54373034
82CBX2_22325352_ChIP-Seq_293T-Rex_Human0.53940470
83P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.53351221
84MYC_19829295_ChIP-Seq_ESCs_Human0.53107679
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.51550501
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.51283941
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.51015034
88NRF2_20460467_ChIP-Seq_MEFs_Mouse0.50665504
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.50665504
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.50337278
91ESR1_21235772_ChIP-Seq_MCF-7_Human0.49265065
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.48776072
93STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.48555897
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.48364872
95CTCF_27219007_Chip-Seq_Bcells_Human0.47971166
96FOXO3_23340844_ChIP-Seq_DLD1_Human0.47865963
97TBL1_22424771_ChIP-Seq_293T_Human0.47861106
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.47728115
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.47612038
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.47220878

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.54595435
2MP0008875_abnormal_xenobiotic_pharmacok6.45959758
3MP0005085_abnormal_gallbladder_physiolo5.57326290
4MP0005365_abnormal_bile_salt5.37241340
5MP0005360_urolithiasis5.04167274
6MP0003195_calcinosis4.27349239
7MP0002138_abnormal_hepatobiliary_system4.08458626
8MP0003252_abnormal_bile_duct3.76402964
9MP0003191_abnormal_cellular_cholesterol3.32859162
10MP0003806_abnormal_nucleotide_metabolis3.09668084
11MP0001666_abnormal_nutrient_absorption2.94581363
12MP0010329_abnormal_lipoprotein_level2.76420618
13MP0005670_abnormal_white_adipose2.73165914
14MP0003868_abnormal_feces_composition2.69755332
15MP0009697_abnormal_copulation2.45821018
16MP0009840_abnormal_foam_cell2.44517591
17MP0005332_abnormal_amino_acid2.39538573
18MP0010368_abnormal_lymphatic_system2.00727472
19MP0000609_abnormal_liver_physiology1.93511210
20MP0002118_abnormal_lipid_homeostasis1.93425678
21MP0002876_abnormal_thyroid_physiology1.84328452
22MP0001764_abnormal_homeostasis1.74900412
23MP0002132_abnormal_respiratory_system1.60991526
24MP0004019_abnormal_vitamin_homeostasis1.36010816
25MP0002971_abnormal_brown_adipose1.31651584
26MP0005319_abnormal_enzyme/_coenzyme1.20050787
27MP0001661_extended_life_span1.17794495
28MP0005584_abnormal_enzyme/coenzyme_acti1.13851829
29MP0009764_decreased_sensitivity_to1.07140982
30MP0003656_abnormal_erythrocyte_physiolo1.01132184
31MP0005408_hypopigmentation1.00275812
32MP0009643_abnormal_urine_homeostasis0.98824877
33MP0009763_increased_sensitivity_to0.98772708
34MP0005376_homeostasis/metabolism_phenot0.98557296
35MP0003186_abnormal_redox_activity0.98487410
36MP0005266_abnormal_metabolism0.96064268
37MP0000598_abnormal_liver_morphology0.94380641
38MP0006036_abnormal_mitochondrial_physio0.93620709
39MP0005334_abnormal_fat_pad0.90347346
40MP0009053_abnormal_anal_canal0.89342365
41MP0009642_abnormal_blood_homeostasis0.89180714
42MP0003011_delayed_dark_adaptation0.85829625
43MP0009115_abnormal_fat_cell0.84869532
44MP0004130_abnormal_muscle_cell0.80165245
45MP0005166_decreased_susceptibility_to0.79257399
46MP0008469_abnormal_protein_level0.78606141
47MP0002078_abnormal_glucose_homeostasis0.77894621
48MP0009785_altered_susceptibility_to0.77702034
49MP0005666_abnormal_adipose_tissue0.76713136
50MP0005535_abnormal_body_temperature0.73791005
51MP0005023_abnormal_wound_healing0.73637589
52MP0002282_abnormal_trachea_morphology0.72984329
53MP0000604_amyloidosis0.71674435
54MP0005187_abnormal_penis_morphology0.71586873
55MP0005636_abnormal_mineral_homeostasis0.69441082
56MP0002249_abnormal_larynx_morphology0.64247948
57MP0005395_other_phenotype0.63458122
58MP0008874_decreased_physiological_sensi0.60774178
59MP0003879_abnormal_hair_cell0.58086448
60MP0005464_abnormal_platelet_physiology0.55678641
61MP0005058_abnormal_lysosome_morphology0.55449418
62MP0008872_abnormal_physiological_respon0.55058022
63MP0001915_intracranial_hemorrhage0.54972283
64MP0002168_other_aberrant_phenotype0.53665056
65MP0005448_abnormal_energy_balance0.53129399
66MP0005451_abnormal_body_composition0.53108469
67MP0005083_abnormal_biliary_tract0.53053331
68MP0000749_muscle_degeneration0.52985713
69MP0002970_abnormal_white_adipose0.52627573
70MP0000249_abnormal_blood_vessel0.52461797
71MP0005330_cardiomyopathy0.51112409
72MP0002332_abnormal_exercise_endurance0.48717974
73MP0009765_abnormal_xenobiotic_induced0.48296052
74MP0003638_abnormal_response/metabolism_0.47457695
75MP0005375_adipose_tissue_phenotype0.47238436
76MP0003959_abnormal_lean_body0.44659604
77MP0005164_abnormal_response_to0.44328553
78MP0002269_muscular_atrophy0.43724131
79MP0003690_abnormal_glial_cell0.42703204
80MP0005647_abnormal_sex_gland0.39748457
81MP0003705_abnormal_hypodermis_morpholog0.37884135
82MP0002136_abnormal_kidney_physiology0.37089038
83MP0009780_abnormal_chondrocyte_physiolo0.36142803
84MP0003953_abnormal_hormone_level0.35758544
85MP0004272_abnormal_basement_membrane0.34339572
86MP0005084_abnormal_gallbladder_morpholo0.34330364
87MP0000467_abnormal_esophagus_morphology0.30974346
88MP0006138_congestive_heart_failure0.30245117
89MP0003075_altered_response_to0.30091809
90MP0003950_abnormal_plasma_membrane0.29853199
91MP0001881_abnormal_mammary_gland0.28608136
92MP0002837_dystrophic_cardiac_calcinosis0.28546983
93MP0005452_abnormal_adipose_tissue0.26302973
94MP0010386_abnormal_urinary_bladder0.25268447
95MP0001845_abnormal_inflammatory_respons0.25076586
96MP0002128_abnormal_blood_circulation0.24700848
97MP0002295_abnormal_pulmonary_circulatio0.23653783
98MP0005397_hematopoietic_system_phenotyp0.23124721
99MP0001545_abnormal_hematopoietic_system0.23124721
100MP0000566_synostosis0.22935920

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)9.44818937
2Deep venous thrombosis (HP:0002625)9.13094174
3Abnormality of complement system (HP:0005339)9.03000316
4Abnormality of aromatic amino acid family metabolism (HP:0004338)8.70169434
5Prolonged partial thromboplastin time (HP:0003645)8.30268062
6Hypobetalipoproteinemia (HP:0003563)7.13391703
7Systemic lupus erythematosus (HP:0002725)6.89963572
8Joint hemorrhage (HP:0005261)6.46863278
9Conjugated hyperbilirubinemia (HP:0002908)5.99969701
10Hyperlipoproteinemia (HP:0010980)5.82751226
11Spontaneous abortion (HP:0005268)5.50159917
12Glomerulonephritis (HP:0000099)5.28416651
13Xanthomatosis (HP:0000991)5.01283237
14Recurrent gram-negative bacterial infections (HP:0005420)5.00024222
15Abnormality of pyrimidine metabolism (HP:0004353)4.62324895
16Abnormality of the intrinsic pathway (HP:0010989)4.60581186
17Abnormality of the common coagulation pathway (HP:0010990)4.57526810
18Intrahepatic cholestasis (HP:0001406)4.46117765
19Hypolipoproteinemia (HP:0010981)4.20827874
20Abnormality of methionine metabolism (HP:0010901)4.15284294
21Nephritis (HP:0000123)3.88966182
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.82709817
23Hyperglycinemia (HP:0002154)3.19286534
24Reduced antithrombin III activity (HP:0001976)3.18785793
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.16491291
26Gingival bleeding (HP:0000225)3.13800419
27Delayed CNS myelination (HP:0002188)3.04549638
28Hypoalphalipoproteinemia (HP:0003233)3.00536897
29Hypercholesterolemia (HP:0003124)2.95757988
30Hyperammonemia (HP:0001987)2.91026048
31Epidermoid cyst (HP:0200040)2.86245981
32Fat malabsorption (HP:0002630)2.82694657
33Generalized aminoaciduria (HP:0002909)2.75099414
34Abnormality of nucleobase metabolism (HP:0010932)2.74405016
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.73480533
36Abnormality of glycine metabolism (HP:0010895)2.69966743
37Abnormality of serine family amino acid metabolism (HP:0010894)2.69966743
38Thrombophlebitis (HP:0004418)2.68759496
39Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63773883
40Hepatocellular carcinoma (HP:0001402)2.60649538
41Neonatal hypoglycemia (HP:0001998)2.52628079
42Purpura (HP:0000979)2.51411527
43Gout (HP:0001997)2.46060455
44Rickets (HP:0002748)2.43669764
45Hyperbilirubinemia (HP:0002904)2.43226284
46Steatorrhea (HP:0002570)2.43128487
47Ketosis (HP:0001946)2.31613805
48Hemorrhage of the eye (HP:0011885)2.24830374
49Hyperglycinuria (HP:0003108)2.21252434
50Abnormality of serum amino acid levels (HP:0003112)2.16332788
51Mitral stenosis (HP:0001718)2.14497428
52Osteomalacia (HP:0002749)2.13114144
53Metabolic acidosis (HP:0001942)2.12174668
54Pulmonary embolism (HP:0002204)2.06694293
55Joint swelling (HP:0001386)2.05816076
56Enlarged kidneys (HP:0000105)2.04423324
57Complement deficiency (HP:0004431)11.1105265
58Fair hair (HP:0002286)1.98480794
59Vascular calcification (HP:0004934)1.98038944
60Abnormal delivery (HP:0001787)1.95018619
61Abnormality of vitamin metabolism (HP:0100508)1.92603817
62Hyperphosphaturia (HP:0003109)1.91507611
63Abnormality of purine metabolism (HP:0004352)1.88275072
64Amyloidosis (HP:0011034)1.86020700
65Cerebral palsy (HP:0100021)1.85013022
66Increased serum ferritin (HP:0003281)1.84934003
67Skin nodule (HP:0200036)1.84875317
68Atrioventricular block (HP:0001678)1.80951223
69Abnormality of iron homeostasis (HP:0011031)1.80708238
70Menorrhagia (HP:0000132)1.75955817
71Cardiovascular calcification (HP:0011915)1.73733297
72Impaired platelet aggregation (HP:0003540)1.71629209
73Abnormal platelet function (HP:0011869)1.71629209
74Cholelithiasis (HP:0001081)1.70047637
75Irritability (HP:0000737)1.68956448
76Elevated alkaline phosphatase (HP:0003155)1.66797292
77Abnormality of urine glucose concentration (HP:0011016)1.66756107
78Glycosuria (HP:0003076)1.66756107
79Facial shape deformation (HP:0011334)1.63854493
80Potter facies (HP:0002009)1.63854493
81Increased mean platelet volume (HP:0011877)1.62814367
82Gangrene (HP:0100758)1.61811901
83Epistaxis (HP:0000421)1.60785563
84Abnormal gallbladder morphology (HP:0012437)1.59746097
85Abnormality of transition element cation homeostasis (HP:0011030)1.59361419
86Abnormal enzyme/coenzyme activity (HP:0012379)1.59047741
87Pancreatitis (HP:0001733)1.56653716
88Hypertriglyceridemia (HP:0002155)1.56438392
89Abnormality of alkaline phosphatase activity (HP:0004379)1.54914215
90Protuberant abdomen (HP:0001538)1.54057501
91Increased serum pyruvate (HP:0003542)1.53761132
92Poikilocytosis (HP:0004447)1.53616647
93Back pain (HP:0003418)1.49065947
94Abnormal urine phosphate concentration (HP:0012599)1.48659114
95Abnormality of fatty-acid metabolism (HP:0004359)1.44470987
96Lethargy (HP:0001254)1.44375697
97Bifid scrotum (HP:0000048)1.43993951
98Abnormal platelet volume (HP:0011876)1.43729122
99Abnormal tarsal ossification (HP:0008369)1.42772927
100Dicarboxylic aciduria (HP:0003215)1.39925436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.40216453
2ERN13.33449682
3OBSCN3.30927198
4ARAF3.26989268
5MST1R3.21376479
6MAP3K132.81658576
7PIK3CG2.55018502
8MAP3K92.41178083
9RIPK12.40403719
10TRIB32.31522681
11EPHA32.10697920
12MARK32.09638394
13FGFR42.05057092
14EPHB12.04070754
15MYLK2.01467318
16MAP3K11.97257237
17MAP3K31.90068853
18NLK1.62071687
19SIK11.58079946
20LATS11.53141160
21TYK21.52378582
22MAPK151.46330308
23TIE11.40129130
24MOS1.36608159
25PRKAA21.34411014
26PIK3CA1.29284785
27PRKACG1.22718421
28MAP3K21.18170450
29PKN21.15010050
30KSR21.14265019
31BCKDK1.12740984
32MET1.11487410
33PDPK11.10751220
34JAK11.08957039
35TGFBR21.07902578
36LMTK21.06870407
37TRPM71.06841380
38MAP2K41.05037622
39ABL21.00782344
40MAPKAPK30.99371909
41STK38L0.98478695
42MAPK120.95625708
43IGF1R0.94076352
44LATS20.90210012
45EPHA20.88932758
46MAP3K120.86774853
47RET0.85585546
48PRPF4B0.84750766
49FGFR30.80499773
50TBK10.78977806
51NME20.78128227
52CAMKK20.77704323
53MUSK0.76951418
54FER0.74702524
55MAPK110.69494973
56PRKG10.68826743
57MAP3K70.67720928
58SGK4940.67464093
59SGK2230.67464093
60MAP3K60.66019795
61PDK10.65910647
62NEK90.63287929
63BLK0.62373579
64TNK20.59012792
65EIF2AK30.56989522
66PRKAA10.56575915
67MAP2K70.56017491
68ICK0.55778203
69RAF10.53457211
70EIF2AK10.53152117
71BRAF0.53048557
72SGK30.51655626
73AKT20.51463356
74SGK20.50693161
75PRKG20.49659115
76CAMK2G0.49623310
77JAK20.48505266
78SCYL20.46068490
79INSRR0.45405934
80MAP3K50.44271832
81PRKACA0.44022545
82PRKACB0.42822124
83EEF2K0.41776081
84STK380.41535221
85KDR0.40013127
86ZAP700.39695322
87BRSK20.39551492
88GRK50.39084715
89PRKCQ0.38638421
90IRAK30.36959858
91ILK0.35908481
92MAPK40.35266459
93MAPK70.33143550
94MAP2K30.32112725
95PRKCZ0.30530780
96MTOR0.29426875
97ERBB20.28429814
98PRKCG0.27906151
99CAMKK10.27041606
100ROCK10.26563248

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.12601357
2Caffeine metabolism_Homo sapiens_hsa002324.18655953
3Complement and coagulation cascades_Homo sapiens_hsa046104.02300272
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.84041356
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.25429074
6Phenylalanine metabolism_Homo sapiens_hsa003603.22237830
7Retinol metabolism_Homo sapiens_hsa008303.16990579
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.84922962
9Chemical carcinogenesis_Homo sapiens_hsa052042.77903686
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.68605580
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.64447360
12Fatty acid degradation_Homo sapiens_hsa000712.45031903
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.44917701
14Tyrosine metabolism_Homo sapiens_hsa003502.42720198
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34292542
16Arginine biosynthesis_Homo sapiens_hsa002202.25518380
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.23304629
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22878854
19Butanoate metabolism_Homo sapiens_hsa006502.01755118
20Histidine metabolism_Homo sapiens_hsa003401.89761978
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85840980
22Tryptophan metabolism_Homo sapiens_hsa003801.74866779
23Linoleic acid metabolism_Homo sapiens_hsa005911.67155131
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.58557790
25Bile secretion_Homo sapiens_hsa049761.57305325
26Vitamin B6 metabolism_Homo sapiens_hsa007501.52658025
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51586306
28Staphylococcus aureus infection_Homo sapiens_hsa051501.50234170
29Prion diseases_Homo sapiens_hsa050201.48943002
30PPAR signaling pathway_Homo sapiens_hsa033201.47658332
31beta-Alanine metabolism_Homo sapiens_hsa004101.45554349
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44410229
33Starch and sucrose metabolism_Homo sapiens_hsa005001.37300084
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.31051213
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27316315
36Peroxisome_Homo sapiens_hsa041461.25521889
37Pyruvate metabolism_Homo sapiens_hsa006201.22379043
38Arachidonic acid metabolism_Homo sapiens_hsa005901.20130939
39Propanoate metabolism_Homo sapiens_hsa006401.13507136
40Biosynthesis of amino acids_Homo sapiens_hsa012301.06418033
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96865796
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96229770
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91642963
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87052307
45Carbon metabolism_Homo sapiens_hsa012000.87009942
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86979954
47Arginine and proline metabolism_Homo sapiens_hsa003300.86324800
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84687954
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84157117
50Fat digestion and absorption_Homo sapiens_hsa049750.71212991
51Fatty acid metabolism_Homo sapiens_hsa012120.70764248
52One carbon pool by folate_Homo sapiens_hsa006700.61918237
53ABC transporters_Homo sapiens_hsa020100.59709324
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58438523
55Sulfur metabolism_Homo sapiens_hsa009200.57387651
56Sulfur relay system_Homo sapiens_hsa041220.44428989
57Pertussis_Homo sapiens_hsa051330.43297393
58Metabolic pathways_Homo sapiens_hsa011000.42695653
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40648872
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.40592263
61Glycerolipid metabolism_Homo sapiens_hsa005610.39067361
62Lysine degradation_Homo sapiens_hsa003100.34770779
63Fatty acid elongation_Homo sapiens_hsa000620.32190078
64Insulin resistance_Homo sapiens_hsa049310.28923950
65Systemic lupus erythematosus_Homo sapiens_hsa053220.26775789
66Glucagon signaling pathway_Homo sapiens_hsa049220.23718163
67Mineral absorption_Homo sapiens_hsa049780.22813922
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.18467060
69Fructose and mannose metabolism_Homo sapiens_hsa000510.17629985
70Pentose phosphate pathway_Homo sapiens_hsa000300.17076294
71AMPK signaling pathway_Homo sapiens_hsa041520.17033922
72Folate biosynthesis_Homo sapiens_hsa007900.16280830
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14861950
74Glutathione metabolism_Homo sapiens_hsa004800.08769123
75Amoebiasis_Homo sapiens_hsa051460.07919200
76Fatty acid biosynthesis_Homo sapiens_hsa000610.07059643
77Steroid biosynthesis_Homo sapiens_hsa001000.05882944
78Renin-angiotensin system_Homo sapiens_hsa046140.05782640
79Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2378675
80FoxO signaling pathway_Homo sapiens_hsa04068-0.2173698
81African trypanosomiasis_Homo sapiens_hsa05143-0.2155577
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.2002900
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1901533
84Sphingolipid metabolism_Homo sapiens_hsa00600-0.1868188
85Nitrogen metabolism_Homo sapiens_hsa00910-0.1829959
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1779796
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1687747
88Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1542303
89Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1521138
90Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1047802
91Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0913445
92alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0745583
93Selenocompound metabolism_Homo sapiens_hsa00450-0.0688024
94Serotonergic synapse_Homo sapiens_hsa04726-0.0686292
95Other glycan degradation_Homo sapiens_hsa00511-0.0582996
96Circadian rhythm_Homo sapiens_hsa04710-0.0552573
97Galactose metabolism_Homo sapiens_hsa00052-0.0451451
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0368586
99Insulin signaling pathway_Homo sapiens_hsa04910-0.0310142
100Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0056374

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