SAA3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1terpenoid biosynthetic process (GO:0016114)8.92128302
2embryonic camera-type eye development (GO:0031076)8.89079155
3negative regulation of cAMP-mediated signaling (GO:0043951)7.30962716
4ganglion development (GO:0061548)6.92508800
5regulation of inclusion body assembly (GO:0090083)6.89933107
6kynurenine metabolic process (GO:0070189)6.70871025
7DNA strand elongation involved in DNA replication (GO:0006271)6.65272694
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.48815237
9mammary gland epithelial cell proliferation (GO:0033598)6.41874888
10indole-containing compound catabolic process (GO:0042436)6.22231282
11indolalkylamine catabolic process (GO:0046218)6.22231282
12tryptophan catabolic process (GO:0006569)6.22231282
13DNA strand elongation (GO:0022616)6.21672519
14DNA replication initiation (GO:0006270)6.20170326
15hypotonic response (GO:0006971)6.11744320
16regulation of timing of cell differentiation (GO:0048505)6.05585014
17mitotic sister chromatid segregation (GO:0000070)5.71491352
18alternative mRNA splicing, via spliceosome (GO:0000380)5.71245299
19negative regulation of potassium ion transmembrane transport (GO:1901380)5.65671662
20ear development (GO:0043583)5.47073597
21regulation of development, heterochronic (GO:0040034)5.44211472
22retinal metabolic process (GO:0042574)5.40694595
23negative regulation of epidermal cell differentiation (GO:0045605)5.39428006
24negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.38704139
25phosphorelay signal transduction system (GO:0000160)5.36546289
26positive regulation of circadian rhythm (GO:0042753)5.31271447
27embryonic viscerocranium morphogenesis (GO:0048703)5.30966739
28SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)5.24475824
29negative regulation of smoothened signaling pathway (GO:0045879)5.18032027
30negative regulation of viral release from host cell (GO:1902187)5.14318428
31acrosome reaction (GO:0007340)5.06604216
32cerebral cortex radially oriented cell migration (GO:0021799)5.01895360
33morphogenesis of an epithelial fold (GO:0060571)4.93308898
34regulation of cilium movement (GO:0003352)4.91528772
35branch elongation of an epithelium (GO:0060602)4.88612085
36sister chromatid segregation (GO:0000819)4.85169330
37lysine catabolic process (GO:0006554)4.83190787
38lysine metabolic process (GO:0006553)4.83190787
39tryptophan metabolic process (GO:0006568)4.77986055
40negative regulation of DNA-templated transcription, elongation (GO:0032785)4.69985638
41organ formation (GO:0048645)4.67721804
42negative regulation of microtubule depolymerization (GO:0007026)4.63900899
43positive regulation of chondrocyte differentiation (GO:0032332)4.58723624
44negative regulation of epidermis development (GO:0045683)4.47515606
45neural crest cell development (GO:0014032)4.35734358
46regulation of microtubule-based movement (GO:0060632)4.34326138
47negative regulation of viral entry into host cell (GO:0046597)4.32560650
48otic vesicle formation (GO:0030916)4.17341794
49morphogenesis of embryonic epithelium (GO:0016331)4.16344875
50positive regulation of cAMP-mediated signaling (GO:0043950)4.12117149
51regulation of microtubule depolymerization (GO:0031114)4.12107906
52cAMP catabolic process (GO:0006198)4.10790264
53lateral sprouting from an epithelium (GO:0060601)4.07592527
54heart contraction (GO:0060047)3.95528438
55heart process (GO:0003015)3.95528438
56axis elongation (GO:0003401)3.92202666
57histone mRNA catabolic process (GO:0071044)3.91067874
58oligodendrocyte differentiation (GO:0048709)3.89345472
59retina layer formation (GO:0010842)3.87648186
60branching involved in mammary gland duct morphogenesis (GO:0060444)3.85258643
61phosphatidylethanolamine biosynthetic process (GO:0006646)3.82805347
62regulation of hydrogen peroxide metabolic process (GO:0010310)3.82471085
63retinoic acid metabolic process (GO:0042573)3.77862549
64heterochromatin organization (GO:0070828)3.69270235
65positive regulation of guanylate cyclase activity (GO:0031284)3.67480587
66amine catabolic process (GO:0009310)3.63906169
67cellular biogenic amine catabolic process (GO:0042402)3.63906169
68somite development (GO:0061053)3.55987255
69cyclic nucleotide catabolic process (GO:0009214)3.55636702
70positive regulation of stem cell differentiation (GO:2000738)3.50348842
71phosphatidylethanolamine metabolic process (GO:0046337)3.48998183
72protein destabilization (GO:0031648)3.48259261
73autophagic vacuole fusion (GO:0000046)3.43744512
74protein polyglutamylation (GO:0018095)3.42638745
75negative regulation of potassium ion transport (GO:0043267)3.40701280
76aromatic amino acid family catabolic process (GO:0009074)3.38573482
77type B pancreatic cell proliferation (GO:0044342)3.35400524
78regulation of guanylate cyclase activity (GO:0031282)3.32461675
79establishment of integrated proviral latency (GO:0075713)3.31747822
80heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.30782425
81ovulation from ovarian follicle (GO:0001542)3.28225503
82ventricular cardiac muscle cell development (GO:0055015)3.27356078
83L-ascorbic acid metabolic process (GO:0019852)3.23847159
84mesenchymal cell development (GO:0014031)3.23053358
85indolalkylamine metabolic process (GO:0006586)3.19907284
86heart valve formation (GO:0003188)3.18912158
87regulation of viral entry into host cell (GO:0046596)3.16904122
88cell volume homeostasis (GO:0006884)3.16820096
89negative regulation of microtubule polymerization or depolymerization (GO:0031111)3.15419738
90regulation of cytokine secretion involved in immune response (GO:0002739)3.11428351
91negative regulation of gene expression, epigenetic (GO:0045814)3.10240000
92positive regulation of cartilage development (GO:0061036)3.06370919
93histone H3-K4 trimethylation (GO:0080182)3.04392303
94isoprenoid biosynthetic process (GO:0008299)3.01485265
95centriole replication (GO:0007099)3.01355414
96epithelial tube branching involved in lung morphogenesis (GO:0060441)3.00876673
97Golgi to endosome transport (GO:0006895)2.99500730
98negative regulation of astrocyte differentiation (GO:0048712)2.98573230
99DNA unwinding involved in DNA replication (GO:0006268)14.1233227
100diterpenoid biosynthetic process (GO:0016102)10.3450638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human9.20183986
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.99114847
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.69580037
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.13085708
5ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.84463163
6PCGF2_27294783_Chip-Seq_NPCs_Mouse2.70370805
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49071101
8VDR_22108803_ChIP-Seq_LS180_Human2.40871593
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.15582406
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12041477
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.07133690
12E2F7_22180533_ChIP-Seq_HELA_Human13.6237329
13TP63_19390658_ChIP-ChIP_HaCaT_Human1.85898766
14CIITA_25753668_ChIP-Seq_RAJI_Human1.83882399
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68567397
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60188121
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.55191599
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42618495
19NFE2_27457419_Chip-Seq_LIVER_Mouse1.42301800
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.36006463
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35213444
22RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32640463
23ZNF274_21170338_ChIP-Seq_K562_Hela1.32370377
24NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31502133
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30120155
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19313952
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15882911
28VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13640081
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.12945495
30FUS_26573619_Chip-Seq_HEK293_Human1.10210988
31BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08513646
32TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07188092
33EZH2_27294783_Chip-Seq_NPCs_Mouse1.06213327
34TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05981626
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.04855746
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03807822
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.02044961
38POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00407821
39SOX3_22085726_ChIP-Seq_NPCs_Mouse0.98042003
40SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95384794
41EWS_26573619_Chip-Seq_HEK293_Human0.95294578
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93870576
43NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91519290
44NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91519290
45SMAD_19615063_ChIP-ChIP_OVARY_Human0.91503946
46ESRRB_18555785_Chip-Seq_ESCs_Mouse0.88389955
47KDM2B_26808549_Chip-Seq_REH_Human0.87740695
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87691290
49CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86419365
50KLF4_18555785_Chip-Seq_ESCs_Mouse0.85676574
51SMAD3_21741376_ChIP-Seq_EPCs_Human0.84487014
52AR_19668381_ChIP-Seq_PC3_Human0.83660334
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80325034
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80325034
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80115771
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79103118
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78376225
58IRF1_19129219_ChIP-ChIP_H3396_Human0.78060861
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77814450
60OCT4_18555785_Chip-Seq_ESCs_Mouse0.77667191
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.77487251
62IGF1R_20145208_ChIP-Seq_DFB_Human0.77416084
63SMAD4_21741376_ChIP-Seq_EPCs_Human0.76878710
64E2F1_18555785_Chip-Seq_ESCs_Mouse0.76741561
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.75621301
66CRX_20693478_ChIP-Seq_RETINA_Mouse0.75602134
67CTCF_27219007_Chip-Seq_Bcells_Human0.75345458
68CMYC_18555785_Chip-Seq_ESCs_Mouse0.75342995
69CTCF_18555785_Chip-Seq_ESCs_Mouse0.74640184
70EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.74595553
71OCT1_27270436_Chip-Seq_PROSTATE_Human0.72616153
72HNFA_21074721_ChIP-Seq_CACO-2_Human0.72382018
73YY1_21170310_ChIP-Seq_MESCs_Mouse0.72254597
74MYC_18940864_ChIP-ChIP_HL60_Human0.71343363
75WDR5_24793694_ChIP-Seq_LNCAP_Human0.69665737
76TBL1_22424771_ChIP-Seq_293T_Human0.69259024
77ARNT_22903824_ChIP-Seq_MCF-7_Human0.67972596
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.67942849
79TCF4_23295773_ChIP-Seq_U87_Human0.67415578
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.67301105
81STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.67077379
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.66111462
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65640034
84STAT3_18555785_Chip-Seq_ESCs_Mouse0.65101920
85OCT4_20526341_ChIP-Seq_ESCs_Human0.64883485
86P53_22387025_ChIP-Seq_ESCs_Mouse0.64779008
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.64428541
88NANOG_18555785_Chip-Seq_ESCs_Mouse0.64218320
89NFYA_21822215_ChIP-Seq_K562_Human0.63967723
90SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.63675104
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63607011
92JARID2_20064375_ChIP-Seq_MESCs_Mouse0.62951362
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.61902098
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.61667926
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.61313963
96RNF2_27304074_Chip-Seq_ESCs_Mouse0.60168384
97P300_18555785_Chip-Seq_ESCs_Mouse0.60135755
98AHR_22903824_ChIP-Seq_MCF-7_Human0.59238384
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.59211433
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.59211433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008260_abnormal_autophagy5.70758338
2MP0003172_abnormal_lysosome_physiology4.76300646
3MP0000566_synostosis4.48707217
4MP0003123_paternal_imprinting3.84770932
5MP0001958_emphysema3.37863594
6MP0010094_abnormal_chromosome_stability3.21538318
7MP0004215_abnormal_myocardial_fiber3.16774133
8MP0003136_yellow_coat_color2.97018323
9MP0006035_abnormal_mitochondrial_morpho2.81145885
10MP0003111_abnormal_nucleus_morphology2.65185996
11MP0000358_abnormal_cell_content/2.54458616
12MP0003950_abnormal_plasma_membrane2.49226140
13MP0003938_abnormal_ear_development2.44444240
14MP0010030_abnormal_orbit_morphology2.37859803
15MP0000749_muscle_degeneration2.09776769
16MP0008789_abnormal_olfactory_epithelium2.04503579
17MP0002233_abnormal_nose_morphology1.91251929
18MP0005394_taste/olfaction_phenotype1.85664105
19MP0005499_abnormal_olfactory_system1.85664105
20MP0001440_abnormal_grooming_behavior1.84788166
21MP0005666_abnormal_adipose_tissue1.84766457
22MP0001270_distended_abdomen1.84710087
23MP0003937_abnormal_limbs/digits/tail_de1.82090515
24MP0003183_abnormal_peptide_metabolism1.79271708
25MP0003186_abnormal_redox_activity1.64855051
26MP0005379_endocrine/exocrine_gland_phen1.63707799
27MP0002249_abnormal_larynx_morphology1.61712768
28MP0002109_abnormal_limb_morphology1.52925395
29MP0006138_congestive_heart_failure1.51367501
30MP0008058_abnormal_DNA_repair1.51184926
31MP0004270_analgesia1.46812702
32MP0002115_abnormal_skeleton_extremities1.44733212
33MP0000428_abnormal_craniofacial_morphol1.39723358
34MP0003786_premature_aging1.38378319
35MP0000631_abnormal_neuroendocrine_gland1.34986569
36MP0005058_abnormal_lysosome_morphology1.34475778
37MP0000383_abnormal_hair_follicle1.32060233
38MP0005409_darkened_coat_color1.31230525
39MP0001286_abnormal_eye_development1.27708072
40MP0005375_adipose_tissue_phenotype1.24446108
41MP0001545_abnormal_hematopoietic_system1.23679682
42MP0005397_hematopoietic_system_phenotyp1.23679682
43MP0002932_abnormal_joint_morphology1.22485131
44MP0009250_abnormal_appendicular_skeleto1.19748844
45MP0001915_intracranial_hemorrhage1.19057274
46MP0002970_abnormal_white_adipose1.16953996
47MP0006292_abnormal_olfactory_placode1.16784089
48MP0003935_abnormal_craniofacial_develop1.16021454
49MP0000647_abnormal_sebaceous_gland1.15083171
50MP0000163_abnormal_cartilage_morphology1.13961039
51MP0000049_abnormal_middle_ear1.11808175
52MP0003121_genomic_imprinting1.10819801
53MP0003890_abnormal_embryonic-extraembry1.07112655
54MP0002163_abnormal_gland_morphology1.06572715
55MP0000432_abnormal_head_morphology1.05810100
56MP0002733_abnormal_thermal_nociception1.01528090
57MP0000427_abnormal_hair_cycle1.01128407
58MP0009697_abnormal_copulation1.00444322
59MP0003943_abnormal_hepatobiliary_system0.97772204
60MP0005595_abnormal_vascular_smooth0.96071396
61MP0002638_abnormal_pupillary_reflex0.95204024
62MP0000639_abnormal_adrenal_gland0.91955907
63MP0009384_cardiac_valve_regurgitation0.90553178
64MP0003936_abnormal_reproductive_system0.89791024
65MP0003119_abnormal_digestive_system0.89077899
66MP0005551_abnormal_eye_electrophysiolog0.88459105
67MP0004859_abnormal_synaptic_plasticity0.88185266
68MP0003942_abnormal_urinary_system0.86574067
69MP0002282_abnormal_trachea_morphology0.86416772
70MP0002909_abnormal_adrenal_gland0.83397915
71MP0003656_abnormal_erythrocyte_physiolo0.83029242
72MP0002113_abnormal_skeleton_development0.81850851
73MP0000470_abnormal_stomach_morphology0.77378930
74MP0002133_abnormal_respiratory_system0.77344209
75MP0005388_respiratory_system_phenotype0.77344209
76MP0005360_urolithiasis0.77004489
77MP0003115_abnormal_respiratory_system0.73188789
78MP0004185_abnormal_adipocyte_glucose0.73052752
79MP0005391_vision/eye_phenotype0.71067239
80MP0000230_abnormal_systemic_arterial0.68683677
81MP0004197_abnormal_fetal_growth/weight/0.68480919
82MP0009764_decreased_sensitivity_to0.67609609
83MP0002067_abnormal_sensory_capabilities0.67606729
84MP0001944_abnormal_pancreas_morphology0.67456375
85MP0000350_abnormal_cell_proliferation0.67125020
86MP0002837_dystrophic_cardiac_calcinosis0.65989873
87MP0008875_abnormal_xenobiotic_pharmacok0.65413426
88MP0001873_stomach_inflammation0.65181371
89MP0001784_abnormal_fluid_regulation0.63325409
90MP0002092_abnormal_eye_morphology0.62368224
91MP0002085_abnormal_embryonic_tissue0.62109585
92MP0001666_abnormal_nutrient_absorption0.61928188
93MP0001175_abnormal_lung_morphology0.61279301
94MP0002896_abnormal_bone_mineralization0.61226564
95MP0005410_abnormal_fertilization0.60761659
96MP0003011_delayed_dark_adaptation0.60452749
97MP0005319_abnormal_enzyme/_coenzyme0.58843419
98MP0002116_abnormal_craniofacial_bone0.58569142
99MP0001299_abnormal_eye_distance/0.58547003
100MP0002084_abnormal_developmental_patter0.57539532

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)9.08281704
2Morphological abnormality of the inner ear (HP:0011390)7.14643734
3Diastasis recti (HP:0001540)6.18389530
4Absent hand (HP:0004050)6.12870071
5Abnormality of lateral ventricle (HP:0030047)5.70288389
6Deep palmar crease (HP:0006191)5.52459817
7Flat capital femoral epiphysis (HP:0003370)5.40568646
8Abnormality of the fingertips (HP:0001211)5.38948663
9Chin dimple (HP:0010751)5.35743869
10Calcaneovalgus deformity (HP:0001848)5.17220202
11Small epiphyses (HP:0010585)4.61315719
12Deformed tarsal bones (HP:0008119)4.58397156
13Abnormality of the calcaneus (HP:0008364)4.55947749
14Conical tooth (HP:0000698)4.45632281
15Absent septum pellucidum (HP:0001331)4.44588200
16Broad distal phalanx of finger (HP:0009836)4.37516057
1711 pairs of ribs (HP:0000878)4.24323663
18Hypoplastic iliac wings (HP:0002866)4.08555122
19Facial cleft (HP:0002006)4.04910744
20Poor speech (HP:0002465)3.97984795
21Carpal bone hypoplasia (HP:0001498)3.88254923
22Abnormality of the septum pellucidum (HP:0007375)3.81203408
23Overlapping toe (HP:0001845)3.75715769
24Tracheomalacia (HP:0002779)3.70793289
25Abnormality of the proximal phalanges of the hand (HP:0009834)3.61776714
26Acute myeloid leukemia (HP:0004808)3.26264264
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24525235
28Neonatal short-limb short stature (HP:0008921)3.17108573
29Delayed epiphyseal ossification (HP:0002663)3.16158566
30Flared metaphyses (HP:0003015)3.15614883
31Vertebral arch anomaly (HP:0008438)3.14270949
32Abnormality of the labia minora (HP:0012880)3.09248418
33Hypoplasia of the capital femoral epiphysis (HP:0003090)3.02755203
34Acanthocytosis (HP:0001927)2.93551073
35Broad phalanges of the hand (HP:0009768)2.85714277
36Abnormality of incisor morphology (HP:0011063)2.81696262
37Thick nail (HP:0001805)2.75339455
38Dyskinesia (HP:0100660)2.72951953
39Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.66260602
40Chromsome breakage (HP:0040012)2.65719294
41Broad finger (HP:0001500)2.62076932
42Irregular epiphyses (HP:0010582)2.59109919
43Absent epiphyses (HP:0010577)2.58900362
44Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.58900362
45Broad thumb (HP:0011304)2.57641198
46Hypoplastic nipples (HP:0002557)2.53489637
47Optic nerve hypoplasia (HP:0000609)2.53118026
48Abnormal sex determination (HP:0012244)2.52159378
49Sex reversal (HP:0012245)2.52159378
50Biconcave vertebral bodies (HP:0004586)2.51833857
51Broad phalanx (HP:0006009)2.44534168
52Bronchomalacia (HP:0002780)2.44109171
53Flattened epiphyses (HP:0003071)2.43356345
54Limited elbow extension (HP:0001377)2.40156744
55Abnormality of the lower motor neuron (HP:0002366)2.37370062
56Drooling (HP:0002307)2.36401131
57Patellar aplasia (HP:0006443)2.34713342
58Hyperglycinuria (HP:0003108)2.32432818
59Hypoplastic ilia (HP:0000946)2.28405070
60Congenital sensorineural hearing impairment (HP:0008527)2.24946466
61Excessive salivation (HP:0003781)2.21729014
62Broad long bones (HP:0005622)2.19398894
63Long nose (HP:0003189)2.16647587
64Erythema (HP:0010783)2.14927847
65Decreased skull ossification (HP:0004331)2.14170384
66Missing ribs (HP:0000921)2.11815122
67Aplasia/Hypoplasia of the patella (HP:0006498)2.11277352
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10856760
69Tetraparesis (HP:0002273)2.07260495
70Alacrima (HP:0000522)2.06670845
71Abnormality of the wing of the ilium (HP:0011867)2.06147384
72Ketoacidosis (HP:0001993)2.06079989
73Abnormality of the incisor (HP:0000676)2.05529073
74Deep philtrum (HP:0002002)2.03847963
75Overriding aorta (HP:0002623)2.03260184
76Abnormality of the antihelix (HP:0009738)2.02829095
77Sandal gap (HP:0001852)1.94002051
78Septo-optic dysplasia (HP:0100842)1.88061322
79Gowers sign (HP:0003391)1.86512925
80Abnormality of midbrain morphology (HP:0002418)1.85639059
81Molar tooth sign on MRI (HP:0002419)1.85639059
82Premature skin wrinkling (HP:0100678)1.85376365
83Irregular vertebral endplates (HP:0003301)1.83841659
84Nephronophthisis (HP:0000090)1.82877119
85Large hands (HP:0001176)1.80857286
86Disinhibition (HP:0000734)1.78477442
87Abnormality of skull ossification (HP:0002703)1.76496154
88Facial hemangioma (HP:0000329)1.75201372
89Stomach cancer (HP:0012126)1.75094609
90Split hand (HP:0001171)1.73749960
91Megalencephaly (HP:0001355)1.72406796
92Hypoplastic toenails (HP:0001800)1.67479072
93Metaphyseal cupping (HP:0003021)1.66539698
94Shallow orbits (HP:0000586)1.65933913
95Hydroureter (HP:0000072)1.64821944
96Hyperacusis (HP:0010780)1.64080571
97Progressive inability to walk (HP:0002505)1.63046312
98Increased IgM level (HP:0003496)1.62430671
99Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.61265255
100Abnormality of the vertebral endplates (HP:0005106)1.59060643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.86878663
2STK384.62683316
3WNK14.39797998
4CDC73.45449415
5EIF2AK12.49380124
6BRSK22.36451959
7EPHA22.25900390
8STK38L11.7926415
9ZAP701.86732889
10CDK191.72998281
11DMPK1.58435745
12FGFR21.57374046
13PINK11.32609510
14CASK1.18257403
15BRSK11.17702755
16MARK31.16929922
17RIPK11.10685631
18PTK2B1.07655309
19TNIK0.91676354
20SIK10.91498771
21PRKG20.86484203
22CSNK1D0.85609602
23CSNK1G20.78688282
24PLK20.72017363
25CSNK1G30.71533124
26CSNK1A1L0.69972340
27CSNK1G10.67886350
28PTK20.64616222
29FRK0.63552852
30GRK10.61483632
31SIK30.61277757
32PRKD20.58826808
33BRD40.58283751
34MARK20.57000859
35JAK20.55080866
36PNCK0.54204648
37NLK0.53230350
38DYRK20.52978926
39CHEK20.51858545
40PAK60.50231503
41MAPK90.49947729
42STK390.49403298
43SIK20.49384652
44IKBKB0.47970774
45STK40.47158055
46ROCK10.46814246
47PRKAA20.45294623
48MAPK80.43950676
49CDK30.43228048
50SGK20.43006821
51CDK50.39020637
52SGK30.38651019
53LYN0.38138201
54DYRK1A0.37435003
55EEF2K0.36324710
56AKT30.34917772
57MTOR0.34107067
58PRKG10.31257340
59CDK20.30768133
60WNK40.30245178
61TAOK10.29572263
62SYK0.29142794
63OXSR10.28959708
64IRAK30.26844329
65GRK50.25609539
66GSK3B0.24820916
67MAPKAPK30.24630527
68INSRR0.23296983
69MAPK140.22861582
70WEE10.22250520
71ATM0.20877262
72PRKCE0.19629215
73MAPK130.19025310
74FES0.18814576
75PLK10.17639901
76AKT10.16890020
77ABL10.16437923
78CDK10.16347773
79PRKACA0.16139184
80SGK2230.15108830
81SGK4940.15108830
82PRKAA10.14803880
83FGFR10.13952940
84PRKCB0.11414384
85TIE10.11245424
86CDK11A0.10902105
87MAPK100.09508270
88NTRK30.09211250
89CSNK2A10.08053144
90PLK30.08021097
91CSNK1E0.07781914
92ERBB20.07729695
93FYN0.06448554
94PKN10.06035334
95MAPK30.05949469
96CSNK1A10.05359197
97PRKACG0.05347569
98PRKDC0.04715117
99STK100.04585783
100LATS10.03939587

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030306.68801604
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.65541368
3Circadian rhythm_Homo sapiens_hsa047103.45415556
4Hedgehog signaling pathway_Homo sapiens_hsa043403.28248120
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.22184098
6Sulfur metabolism_Homo sapiens_hsa009202.77970400
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.76927408
8Sulfur relay system_Homo sapiens_hsa041222.67004673
9Tryptophan metabolism_Homo sapiens_hsa003802.58298768
10Retinol metabolism_Homo sapiens_hsa008302.50277483
11Regulation of autophagy_Homo sapiens_hsa041402.45339947
12Proteasome_Homo sapiens_hsa030502.44540047
13Shigellosis_Homo sapiens_hsa051312.43436850
14Phototransduction_Homo sapiens_hsa047442.22457753
15Fanconi anemia pathway_Homo sapiens_hsa034602.21601978
16Non-homologous end-joining_Homo sapiens_hsa034502.16378390
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.16039475
18Nitrogen metabolism_Homo sapiens_hsa009102.12664258
19Lysine degradation_Homo sapiens_hsa003101.99705258
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85441395
21Starch and sucrose metabolism_Homo sapiens_hsa005001.76933244
22Galactose metabolism_Homo sapiens_hsa000521.63923213
23Renin-angiotensin system_Homo sapiens_hsa046141.54916467
24Glycerolipid metabolism_Homo sapiens_hsa005611.52335515
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32472040
26Small cell lung cancer_Homo sapiens_hsa052221.31788430
27Morphine addiction_Homo sapiens_hsa050321.20541466
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18303929
29Notch signaling pathway_Homo sapiens_hsa043301.17734374
30Protein export_Homo sapiens_hsa030601.12890407
31Chemical carcinogenesis_Homo sapiens_hsa052041.07689992
32Protein digestion and absorption_Homo sapiens_hsa049740.99702447
33ECM-receptor interaction_Homo sapiens_hsa045120.99677491
34Hippo signaling pathway_Homo sapiens_hsa043900.99621502
35Basal cell carcinoma_Homo sapiens_hsa052170.96107837
36Cell cycle_Homo sapiens_hsa041100.95311211
37Steroid hormone biosynthesis_Homo sapiens_hsa001400.92738759
38Glycerophospholipid metabolism_Homo sapiens_hsa005640.90369161
39Nucleotide excision repair_Homo sapiens_hsa034200.88440493
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83560386
41Wnt signaling pathway_Homo sapiens_hsa043100.82958249
42Caffeine metabolism_Homo sapiens_hsa002320.81202147
43Mismatch repair_Homo sapiens_hsa034300.79846931
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79488524
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78992907
46Choline metabolism in cancer_Homo sapiens_hsa052310.78180351
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70389868
48Linoleic acid metabolism_Homo sapiens_hsa005910.67336114
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64364348
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.63687673
51N-Glycan biosynthesis_Homo sapiens_hsa005100.59380044
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54956810
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49092318
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47436433
55Adherens junction_Homo sapiens_hsa045200.46730954
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42810283
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40722351
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40290536
59Peroxisome_Homo sapiens_hsa041460.39052107
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.38433528
61Amoebiasis_Homo sapiens_hsa051460.38215607
62B cell receptor signaling pathway_Homo sapiens_hsa046620.36562949
63Biosynthesis of amino acids_Homo sapiens_hsa012300.36514432
64Cocaine addiction_Homo sapiens_hsa050300.35048951
65Huntingtons disease_Homo sapiens_hsa050160.34146246
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30542144
67Primary immunodeficiency_Homo sapiens_hsa053400.30447320
68One carbon pool by folate_Homo sapiens_hsa006700.29715497
69Pancreatic cancer_Homo sapiens_hsa052120.29630601
70Arachidonic acid metabolism_Homo sapiens_hsa005900.28961394
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28772026
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28004512
73Fructose and mannose metabolism_Homo sapiens_hsa000510.27636820
74Arginine and proline metabolism_Homo sapiens_hsa003300.26461623
75Histidine metabolism_Homo sapiens_hsa003400.25629158
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24356025
77Taste transduction_Homo sapiens_hsa047420.23650412
78Basal transcription factors_Homo sapiens_hsa030220.22334084
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.21337351
80Metabolic pathways_Homo sapiens_hsa011000.21133015
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17383326
82MicroRNAs in cancer_Homo sapiens_hsa052060.17296688
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16842630
84Ovarian steroidogenesis_Homo sapiens_hsa049130.16562476
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16020837
86Pathways in cancer_Homo sapiens_hsa052000.15957331
87Ras signaling pathway_Homo sapiens_hsa040140.15812407
88Tight junction_Homo sapiens_hsa045300.15332637
89Cardiac muscle contraction_Homo sapiens_hsa042600.14932979
90VEGF signaling pathway_Homo sapiens_hsa043700.14895320
91ABC transporters_Homo sapiens_hsa020100.14545728
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.13576071
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.13145711
94Spliceosome_Homo sapiens_hsa030400.10678154
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10075883
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09480145
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.08756389
98cAMP signaling pathway_Homo sapiens_hsa040240.08586586
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08109449
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07970078

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