ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	exogenous drug catabolic process (GO:0042738)	8.11013076
2	L-phenylalanine catabolic process (GO:0006559)	7.56737590
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.56737590
4	epoxygenase P450 pathway (GO:0019373)	7.41558351
5	L-phenylalanine metabolic process (GO:0006558)	7.23835001
6	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.23835001
7	omega-hydroxylase P450 pathway (GO:0097267)	7.01210016
8	aromatic amino acid family catabolic process (GO:0009074)	6.93768288
9	tryptophan catabolic process (GO:0006569)	6.42774072
10	indole-containing compound catabolic process (GO:0042436)	6.42774072
11	indolalkylamine catabolic process (GO:0046218)	6.42774072
12	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.25615327
13	kynurenine metabolic process (GO:0070189)	6.23055333
14	tryptophan metabolic process (GO:0006568)	6.01665461
15	bile acid biosynthetic process (GO:0006699)	6.00870310
16	regulation of plasminogen activation (GO:0010755)	5.90166400
17	glyoxylate metabolic process (GO:0046487)	5.73679584
18	complement activation, alternative pathway (GO:0006957)	5.72782896
19	regulation of protein activation cascade (GO:2000257)	5.72130004
20	negative regulation of fibrinolysis (GO:0051918)	5.66946786
21	urea cycle (GO:0000050)	5.66655945
22	urea metabolic process (GO:0019627)	5.66655945
23	drug metabolic process (GO:0017144)	5.58661754
24	protein carboxylation (GO:0018214)	5.55205444
25	peptidyl-glutamic acid carboxylation (GO:0017187)	5.55205444
26	high-density lipoprotein particle remodeling (GO:0034375)	5.54932374
27	regulation of fibrinolysis (GO:0051917)	5.52201551
28	alpha-linolenic acid metabolic process (GO:0036109)	5.40851407
29	oxidative demethylation (GO:0070989)	5.35503064
30	regulation of complement activation (GO:0030449)	5.32781641
31	nitrogen cycle metabolic process (GO:0071941)	5.20293476
32	cysteine metabolic process (GO:0006534)	5.14522186
33	sulfur amino acid catabolic process (GO:0000098)	5.14396591
34	phenylpropanoid metabolic process (GO:0009698)	5.12656749
35	bile acid metabolic process (GO:0008206)	5.11311519
36	serine family amino acid catabolic process (GO:0009071)	5.04673856
37	aromatic amino acid family metabolic process (GO:0009072)	5.02799742
38	ethanol metabolic process (GO:0006067)	4.95979829
39	negative regulation of blood coagulation (GO:0030195)	4.95838161
40	negative regulation of hemostasis (GO:1900047)	4.95838161
41	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.90093455
42	regulation of triglyceride catabolic process (GO:0010896)	4.86715666
43	regulation of cholesterol esterification (GO:0010872)	4.86605954
44	reverse cholesterol transport (GO:0043691)	4.83696176
45	tyrosine metabolic process (GO:0006570)	4.78835955
46	regulation of humoral immune response (GO:0002920)	4.73995441
47	macromolecular complex remodeling (GO:0034367)	4.73361399
48	plasma lipoprotein particle remodeling (GO:0034369)	4.73361399
49	protein-lipid complex remodeling (GO:0034368)	4.73361399
50	triglyceride homeostasis (GO:0070328)	4.65642536
51	acylglycerol homeostasis (GO:0055090)	4.65642536
52	homocysteine metabolic process (GO:0050667)	4.63242601
53	phospholipid efflux (GO:0033700)	4.62668964
54	alpha-amino acid catabolic process (GO:1901606)	4.62538963
55	coenzyme catabolic process (GO:0009109)	4.55860359
56	indolalkylamine metabolic process (GO:0006586)	4.53869932
57	lysine catabolic process (GO:0006554)	4.53782245
58	lysine metabolic process (GO:0006553)	4.53782245
59	negative regulation of coagulation (GO:0050819)	4.52126040
60	amino-acid betaine metabolic process (GO:0006577)	4.51750058
61	negative regulation of cholesterol transport (GO:0032375)	4.51336898
62	negative regulation of sterol transport (GO:0032372)	4.51336898
63	amine catabolic process (GO:0009310)	4.49024120
64	cellular biogenic amine catabolic process (GO:0042402)	4.49024120
65	negative regulation of wound healing (GO:0061045)	4.48530553
66	bile acid and bile salt transport (GO:0015721)	4.42352492
67	imidazole-containing compound metabolic process (GO:0052803)	4.36333193
68	cellular ketone body metabolic process (GO:0046950)	4.30884208
69	positive regulation of hemostasis (GO:1900048)	4.30675266
70	positive regulation of blood coagulation (GO:0030194)	4.30675266
71	glycine metabolic process (GO:0006544)	4.29746487
72	plasma lipoprotein particle clearance (GO:0034381)	4.27501714
73	cellular glucuronidation (GO:0052695)	4.26453510
74	cellular amino acid catabolic process (GO:0009063)	4.22365465
75	cholesterol efflux (GO:0033344)	4.21938872
76	benzene-containing compound metabolic process (GO:0042537)	4.17684296
77	glutamate metabolic process (GO:0006536)	4.17275615
78	intestinal cholesterol absorption (GO:0030299)	4.13291284
79	fibrinolysis (GO:0042730)	4.10498170
80	S-adenosylmethionine metabolic process (GO:0046500)	4.09302194
81	serine family amino acid metabolic process (GO:0009069)	4.08525913
82	complement activation, classical pathway (GO:0006958)	4.06578503
83	arginine metabolic process (GO:0006525)	4.04077831
84	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.01315990
85	dicarboxylic acid biosynthetic process (GO:0043650)	4.00264976
86	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.99665449
87	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.99665449
88	ethanol oxidation (GO:0006069)	3.99503470
89	cellular modified amino acid catabolic process (GO:0042219)	3.98531296
90	cytolysis (GO:0019835)	3.98513575
91	complement activation (GO:0006956)	3.97183408
92	positive regulation of coagulation (GO:0050820)	3.95970645
93	negative regulation of complement activation (GO:0045916)	3.95915345
94	blood coagulation, intrinsic pathway (GO:0007597)	3.93269916
95	protein activation cascade (GO:0072376)	3.93121696
96	plasma lipoprotein particle assembly (GO:0034377)	3.92853169
97	drug catabolic process (GO:0042737)	3.90689577
98	low-density lipoprotein particle remodeling (GO:0034374)	3.90065684
99	alkaloid metabolic process (GO:0009820)	3.89366384
100	serine family amino acid biosynthetic process (GO:0009070)	3.88373291
101	aldehyde catabolic process (GO:0046185)	3.88326077
102	cofactor catabolic process (GO:0051187)	3.87322875
103	negative regulation of lipase activity (GO:0060192)	3.81454163
104	positive regulation of lipoprotein lipase activity (GO:0051006)	3.81209540
105	positive regulation of triglyceride lipase activity (GO:0061365)	3.81209540
106	* acute inflammatory response (GO:0002526)	3.79386753
107	glucuronate metabolic process (GO:0019585)	3.78223546
108	uronic acid metabolic process (GO:0006063)	3.78223546
109	opsonization (GO:0008228)	3.77969874
110	regulation of bile acid biosynthetic process (GO:0070857)	3.77828040
111	flavonoid metabolic process (GO:0009812)	3.77644085
112	hormone catabolic process (GO:0042447)	3.76501804
113	negative regulation of protein activation cascade (GO:2000258)	3.73937031
114	very-low-density lipoprotein particle assembly (GO:0034379)	3.73816568
115	NAD biosynthetic process (GO:0009435)	3.73086127
116	ketone body metabolic process (GO:1902224)	3.72306344
117	plasma lipoprotein particle organization (GO:0071827)	3.72036095
118	positive regulation of lipid catabolic process (GO:0050996)	3.69091342
119	phospholipid homeostasis (GO:0055091)	3.68934331
120	cholesterol homeostasis (GO:0042632)	3.68710616
121	* acute-phase response (GO:0006953)	3.68198836
122	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.67562221
123	carboxylic acid catabolic process (GO:0046395)	3.66751421
124	organic acid catabolic process (GO:0016054)	3.66751421
125	daunorubicin metabolic process (GO:0044597)	3.65447326
126	polyketide metabolic process (GO:0030638)	3.65447326
127	doxorubicin metabolic process (GO:0044598)	3.65447326
128	regulation of cholesterol homeostasis (GO:2000188)	3.63988954
129	sterol homeostasis (GO:0055092)	3.63033934
130	pyridine nucleotide biosynthetic process (GO:0019363)	3.61637675
131	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.61637675
132	regulation of lipoprotein particle clearance (GO:0010984)	3.60791962
133	regulation of apoptotic cell clearance (GO:2000425)	3.55191532

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	8.31678412
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	7.17370389
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	7.12369156
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	6.45024081
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.32399591
6	* CEBPA_23403033_ChIP-Seq_LIVER_Mouse	5.05917239
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.59776190
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	4.12135095
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	4.07837731
10	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.01217896
11	* ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.8577284
12	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.87638204
13	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.81279506
14	HTT_18923047_ChIP-ChIP_STHdh_Human	1.60993933
15	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.60392189
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.59121036
17	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.53366882
18	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.38983227
19	GATA1_22025678_ChIP-Seq_K562_Human	1.38573216
20	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.37189583
21	CLOCK_20551151_ChIP-Seq_293T_Human	1.33578233
22	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.26301781
23	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.23400392
24	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.20150597
25	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.18271816
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.03941109
27	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.01861857
28	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.99577763
29	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.99465171
30	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.92208998
31	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.85440688
32	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.84912991
33	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.83441335
34	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.83291638
35	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.80781546
36	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.78898165
37	GATA4_25053715_ChIP-Seq_YYC3_Human	0.76503313
38	GATA6_25053715_ChIP-Seq_YYC3_Human	0.76306097
39	SOX2_21211035_ChIP-Seq_LN229_Human	0.74226551
40	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.74020549
41	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.74007479
42	* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.73635519
43	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.72706192
44	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.70587031
45	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.67448908
46	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.67217927
47	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.67136416
48	RAC3_21632823_ChIP-Seq_H3396_Human	0.67005891
49	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.66537514
50	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.66537514
51	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.66195120
52	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.65817317
53	SOX2_20726797_ChIP-Seq_SW620_Human	0.65713158
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.65429195
55	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.63511807
56	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.62666275
57	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.62072021
58	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.62029968
59	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.61803096
60	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.61598673
61	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.61285823
62	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.61098310
63	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.60909159
64	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.60715406
65	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.60103759
66	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.59563207
67	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.59355428
68	TAF15_26573619_Chip-Seq_HEK293_Human	0.59024600
69	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.57254412
70	SMC4_20622854_ChIP-Seq_HELA_Human	0.56683327
71	TP53_18474530_ChIP-ChIP_U2OS_Human	0.56181524
72	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.55916226
73	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.55284347
74	AR_20517297_ChIP-Seq_VCAP_Human	0.54778949
75	SPI1_20517297_ChIP-Seq_HL60_Human	0.54433676
76	CEBPB_22108803_ChIP-Seq_LS180_Human	0.54369472
77	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.52982534
78	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.52621666
79	STAT1_17558387_ChIP-Seq_HELA_Human	0.52514081
80	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.52320664
81	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.52083604
82	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.51961887
83	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.51533321
84	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.51405735
85	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.51341814
86	EGR1_19032775_ChIP-ChIP_M12_Human	0.51324069
87	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.51087157
88	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.51051829
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.51048349
90	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.50994108
91	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.50878710
92	CBP_21632823_ChIP-Seq_H3396_Human	0.50731394
93	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.50592687
94	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.50183641
95	MYC_19915707_ChIP-ChIP_AK7_Human	0.49700896
96	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.49673778
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.49393892
98	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.48584382
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.48392669
100	CTCF_27219007_Chip-Seq_Bcells_Human	0.48146240
101	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.47622008
102	SA1_27219007_Chip-Seq_Bcells_Human	0.47554048
103	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.47482604
104	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.47258292
105	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.47224198
106	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.44991088
107	IRF1_19129219_ChIP-ChIP_H3396_Human	0.44936394
108	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.43328380
109	BCAT_22108803_ChIP-Seq_LS180_Human	0.42828437
110	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.42710995
111	TAF2_19829295_ChIP-Seq_ESCs_Human	0.42475793
112	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.42318986
113	LXR_22292898_ChIP-Seq_THP-1_Human	0.42261731
114	P53_21459846_ChIP-Seq_SAOS-2_Human	0.41583939
115	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.40993267
116	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.40052704
117	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.39831184
118	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.39643916
119	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.39373444
120	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.38847536
121	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.38769986
122	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.38335256
123	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.38289417
124	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.37456176
125	GATA2_19941826_ChIP-Seq_K562_Human	0.37377156
126	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.36958704
127	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.36909647
128	CDX2_22108803_ChIP-Seq_LS180_Human	0.36746407
129	ZNF263_19887448_ChIP-Seq_K562_Human	0.36095256
130	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.35035879
131	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.35033731
132	GATA1_19941826_ChIP-Seq_K562_Human	0.34944123
133	SPI1_26923725_Chip-Seq_HPCs_Mouse	0.34776909
134	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.34619883

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.31743303
2	MP0005360_urolithiasis	7.50770259
3	MP0005085_abnormal_gallbladder_physiolo	6.53124318
4	MP0005365_abnormal_bile_salt	6.20369559
5	MP0008875_abnormal_xenobiotic_pharmacok	5.08841757
6	MP0003806_abnormal_nucleotide_metabolis	4.21432593
7	MP0003252_abnormal_bile_duct	3.92737614
8	MP0010329_abnormal_lipoprotein_level	3.59756752
9	MP0009840_abnormal_foam_cell	3.21676049
10	MP0005083_abnormal_biliary_tract	3.04074552
11	MP0003195_calcinosis	2.81854320
12	MP0005332_abnormal_amino_acid	2.71065454
13	MP0001666_abnormal_nutrient_absorption	2.58761410
14	MP0003191_abnormal_cellular_cholesterol	2.49389146
15	MP0000609_abnormal_liver_physiology	2.15653111
16	MP0004019_abnormal_vitamin_homeostasis	2.11671784
17	MP0002118_abnormal_lipid_homeostasis	2.09841996
18	MP0003868_abnormal_feces_composition	1.97703811
19	MP0002138_abnormal_hepatobiliary_system	1.93931618
20	MP0005319_abnormal_enzyme/_coenzyme	1.82886390
21	MP0009697_abnormal_copulation	1.74224226
22	MP0001764_abnormal_homeostasis	1.66462616
23	MP0005584_abnormal_enzyme/coenzyme_acti	1.53173998
24	MP0003011_delayed_dark_adaptation	1.37110850
25	MP0005451_abnormal_body_composition	1.35380693
26	MP0005647_abnormal_sex_gland	1.27467850
27	MP0003656_abnormal_erythrocyte_physiolo	1.22306969
28	MP0003186_abnormal_redox_activity	1.20834701
29	MP0009643_abnormal_urine_homeostasis	1.19223034
30	MP0000598_abnormal_liver_morphology	1.15604600
31	MP0009764_decreased_sensitivity_to	1.14911840
32	MP0009763_increased_sensitivity_to	1.05561230
33	MP0003705_abnormal_hypodermis_morpholog	1.04520386
34	MP0002254_reproductive_system_inflammat	1.03408859
35	MP0000604_amyloidosis	1.02774090
36	MP0010368_abnormal_lymphatic_system	1.02435149
37	MP0001915_intracranial_hemorrhage	1.00048272
38	MP0005670_abnormal_white_adipose	0.98491237
39	MP0008469_abnormal_protein_level	0.93519833
40	MP0005636_abnormal_mineral_homeostasis	0.92243653
41	MP0009642_abnormal_blood_homeostasis	0.87910570
42	MP0002876_abnormal_thyroid_physiology	0.84056955
43	MP0005408_hypopigmentation	0.81986970
44	MP0009765_abnormal_xenobiotic_induced	0.78381185
45	MP0005084_abnormal_gallbladder_morpholo	0.76764580
46	MP0005376_homeostasis/metabolism_phenot	0.76712994
47	MP0003879_abnormal_hair_cell	0.76143899
48	MP0002078_abnormal_glucose_homeostasis	0.75640327
49	MP0005220_abnormal_exocrine_pancreas	0.75246398
50	MP0006036_abnormal_mitochondrial_physio	0.72311271
51	MP0002971_abnormal_brown_adipose	0.70638233
52	MP0005334_abnormal_fat_pad	0.70244049
53	MP0003690_abnormal_glial_cell	0.69007755
54	MP0002282_abnormal_trachea_morphology	0.67062980
55	MP0005535_abnormal_body_temperature	0.66401906
56	MP0005187_abnormal_penis_morphology	0.65713345
57	MP0009053_abnormal_anal_canal	0.64575981
58	MP0005058_abnormal_lysosome_morphology	0.62627249
59	MP0004130_abnormal_muscle_cell	0.61904799
60	MP0001661_extended_life_span	0.61703876
61	MP0000639_abnormal_adrenal_gland	0.61536026
62	MP0005464_abnormal_platelet_physiology	0.59754726
63	MP0005266_abnormal_metabolism	0.59346569
64	MP0004782_abnormal_surfactant_physiolog	0.54349529
65	MP0002249_abnormal_larynx_morphology	0.54319530
66	MP0005023_abnormal_wound_healing	0.54027576
67	MP0003724_increased_susceptibility_to	0.52771133
68	MP0005448_abnormal_energy_balance	0.52151235
69	MP0001756_abnormal_urination	0.52038182
70	MP0009785_altered_susceptibility_to	0.51508345
71	MP0000566_synostosis	0.51342713
72	MP0004381_abnormal_hair_follicle	0.50172431
73	MP0002089_abnormal_postnatal_growth/wei	0.49778412
74	MP0005395_other_phenotype	0.49692785
75	MP0006035_abnormal_mitochondrial_morpho	0.49239732
76	MP0002928_abnormal_bile_duct	0.49184728
77	MP0003436_decreased_susceptibility_to	0.48951710
78	MP0002822_catalepsy	0.47992845
79	MP0003329_amyloid_beta_deposits	0.47637010
80	MP0005248_abnormal_Harderian_gland	0.46105511
81	MP0003718_maternal_effect	0.45993790
82	MP0008874_decreased_physiological_sensi	0.45303249
83	MP0005166_decreased_susceptibility_to	0.45214828
84	MP0003638_abnormal_response/metabolism_	0.44927541
85	MP0002136_abnormal_kidney_physiology	0.43422733
86	MP0002132_abnormal_respiratory_system	0.42235719
87	MP0000579_abnormal_nail_morphology	0.42121789
88	MP0003075_altered_response_to	0.40511078
89	MP0008873_increased_physiological_sensi	0.40374962
90	MP0003953_abnormal_hormone_level	0.40219416
91	MP0006082_CNS_inflammation	0.38145434
92	MP0005666_abnormal_adipose_tissue	0.37313841
93	MP0009384_cardiac_valve_regurgitation	0.35007466
94	MP0003172_abnormal_lysosome_physiology	0.34865277
95	MP0008872_abnormal_physiological_respon	0.33926071
96	MP0009115_abnormal_fat_cell	0.33338057
97	MP0001881_abnormal_mammary_gland	0.31977043
98	MP0009672_abnormal_birth_weight	0.31053598
99	MP0000249_abnormal_blood_vessel	0.30611114
100	MP0002168_other_aberrant_phenotype	0.30284688
101	MP0002837_dystrophic_cardiac_calcinosis	0.30247939
102	MP0004883_abnormal_blood_vessel	0.30097841
103	MP0001845_abnormal_inflammatory_respons	0.29918984
104	MP0001853_heart_inflammation	0.29541853
105	MP0002970_abnormal_white_adipose	0.28400320
106	MP0000230_abnormal_systemic_arterial	0.28102880
107	MP0002796_impaired_skin_barrier	0.28046183
108	MP0000427_abnormal_hair_cycle	0.27958646
109	MP0000467_abnormal_esophagus_morphology	0.26499734
110	MP0001243_abnormal_dermal_layer	0.26476338
111	MP0005164_abnormal_response_to	0.24678913
112	MP0002060_abnormal_skin_morphology	0.24291419
113	MP0005167_abnormal_blood-brain_barrier	0.22539074
114	MP0002090_abnormal_vision	0.20627275
115	MP0000920_abnormal_myelination	0.20587897
116	MP0005197_abnormal_uvea_morphology	0.18274824
117	MP0003959_abnormal_lean_body	0.18220499
118	MP0004272_abnormal_basement_membrane	0.17469914
119	MP0003878_abnormal_ear_physiology	0.17135255
120	MP0005377_hearing/vestibular/ear_phenot	0.17135255
121	MP0002128_abnormal_blood_circulation	0.16708816
122	MP0003632_abnormal_nervous_system	0.16252153

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	7.47469433
2	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.37086675
3	Intrahepatic cholestasis (HP:0001406)	7.34438241
4	Prolonged partial thromboplastin time (HP:0003645)	6.83095503
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.66685040
6	Hypobetalipoproteinemia (HP:0003563)	6.27879028
7	Xanthomatosis (HP:0000991)	6.15358665
8	Complement deficiency (HP:0004431)	5.98224707
9	Hyperlipoproteinemia (HP:0010980)	5.61784544
10	Joint hemorrhage (HP:0005261)	5.01943360
11	Abnormality of the common coagulation pathway (HP:0010990)	4.74909756
12	Hypolipoproteinemia (HP:0010981)	4.72073051
13	Hyperammonemia (HP:0001987)	4.52524009
14	Epidermoid cyst (HP:0200040)	4.45068884
15	Hyperglycinemia (HP:0002154)	4.44960408
16	Abnormality of complement system (HP:0005339)	4.36421209
17	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.32209640
18	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.19897186
19	Fat malabsorption (HP:0002630)	4.19775973
20	Abnormality of methionine metabolism (HP:0010901)	4.19570276
21	Ketosis (HP:0001946)	4.18070648
22	Hypoalphalipoproteinemia (HP:0003233)	4.17514608
23	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.11023989
24	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.04573044
25	Conjugated hyperbilirubinemia (HP:0002908)	3.93089721
26	Abnormality of the intrinsic pathway (HP:0010989)	3.91142796
27	Abnormality of pyrimidine metabolism (HP:0004353)	3.89481194
28	Abnormality of glycine metabolism (HP:0010895)	3.82941476
29	Abnormality of serine family amino acid metabolism (HP:0010894)	3.82941476
30	Hypoglycemic coma (HP:0001325)	3.79274902
31	Hyperglycinuria (HP:0003108)	3.78403710
32	Spontaneous abortion (HP:0005268)	3.55651080
33	Hypercholesterolemia (HP:0003124)	3.52643214
34	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.27349339
35	Hyperbilirubinemia (HP:0002904)	3.25750948
36	Steatorrhea (HP:0002570)	3.24789491
37	Abnormality of fatty-acid metabolism (HP:0004359)	3.24264869
38	Systemic lupus erythematosus (HP:0002725)	3.09497653
39	Hypochromic microcytic anemia (HP:0004840)	3.08070389
40	Myocardial infarction (HP:0001658)	3.06253873
41	Abnormality of nucleobase metabolism (HP:0010932)	3.05559563
42	Abnormality of serum amino acid levels (HP:0003112)	3.04191042
43	Delayed CNS myelination (HP:0002188)	3.02120994
44	Hepatocellular carcinoma (HP:0001402)	2.93682145
45	Ketoacidosis (HP:0001993)	2.90351445
46	Purpura (HP:0000979)	2.85431331
47	Recurrent gram-negative bacterial infections (HP:0005420)	2.78404665
48	Metabolic acidosis (HP:0001942)	2.71595589
49	Skin nodule (HP:0200036)	2.68133379
50	Vascular calcification (HP:0004934)	2.64236299
51	Abnormality of purine metabolism (HP:0004352)	2.63598748
52	Hypoglycemic seizures (HP:0002173)	2.59915078
53	Glomerulonephritis (HP:0000099)	2.57174220
54	Mitral stenosis (HP:0001718)	2.56245493
55	Gingival bleeding (HP:0000225)	2.55151098
56	Osteomalacia (HP:0002749)	2.52726258
57	Reduced antithrombin III activity (HP:0001976)	2.52495481
58	Lethargy (HP:0001254)	2.51570712
59	Amyloidosis (HP:0011034)	2.46172931
60	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.45642270
61	Dicarboxylic aciduria (HP:0003215)	2.45642270
62	Abnormal gallbladder morphology (HP:0012437)	2.37509051
63	Spastic diplegia (HP:0001264)	2.36910656
64	Acanthocytosis (HP:0001927)	2.35972511
65	Gout (HP:0001997)	2.33645837
66	Cholelithiasis (HP:0001081)	2.33145492
67	Cardiovascular calcification (HP:0011915)	2.33087369
68	Neonatal onset (HP:0003623)	2.32887238
69	Cerebral edema (HP:0002181)	2.28416545
70	Cholecystitis (HP:0001082)	2.27128377
71	Abnormal gallbladder physiology (HP:0012438)	2.27128377
72	Irritability (HP:0000737)	2.26157898
73	Thrombophlebitis (HP:0004418)	2.25561085
74	Menorrhagia (HP:0000132)	2.25199128
75	Enlarged kidneys (HP:0000105)	2.17819859
76	Arthropathy (HP:0003040)	2.17042011
77	Malnutrition (HP:0004395)	2.15554598
78	Sensorimotor neuropathy (HP:0007141)	2.14646779
79	Late onset (HP:0003584)	2.14432876
80	Esophageal varix (HP:0002040)	2.13856094
81	Pancreatitis (HP:0001733)	2.13257965
82	Opisthotonus (HP:0002179)	2.12473875
83	Abnormality of the Achilles tendon (HP:0005109)	2.12437163
84	Fair hair (HP:0002286)	2.09975103
85	Brushfield spots (HP:0001088)	2.09861419
86	Hemorrhage of the eye (HP:0011885)	2.05529259
87	Hyperinsulinemic hypoglycemia (HP:0000825)	2.02501604
88	Neonatal hypoglycemia (HP:0001998)	2.02176722
89	Vomiting (HP:0002013)	2.00162959
90	Hyperphosphaturia (HP:0003109)	1.99254517
91	Generalized aminoaciduria (HP:0002909)	1.97129403
92	Renal cortical cysts (HP:0000803)	1.94772311
93	Hypophosphatemic rickets (HP:0004912)	1.93814105
94	Rickets (HP:0002748)	1.93524795
95	Abnormality of the gallbladder (HP:0005264)	1.93388459
96	Abnormality of iron homeostasis (HP:0011031)	1.93310026
97	Poikilocytosis (HP:0004447)	1.91686790
98	Gangrene (HP:0100758)	1.91108428
99	Bifid scrotum (HP:0000048)	1.90235545
100	Increased serum ferritin (HP:0003281)	1.90215901
101	Hydroxyprolinuria (HP:0003080)	1.90086116
102	Abnormality of proline metabolism (HP:0010907)	1.90086116
103	Abnormality of transition element cation homeostasis (HP:0011030)	1.88943308
104	Joint swelling (HP:0001386)	1.88359132
105	Abnormal enzyme/coenzyme activity (HP:0012379)	1.84065051
106	Status epilepticus (HP:0002133)	1.83565233
107	Elevated hepatic transaminases (HP:0002910)	1.83468606
108	Hyperglycemia (HP:0003074)	1.80721345
109	Nephritis (HP:0000123)	1.80506799
110	Glycosuria (HP:0003076)	1.79688412
111	Abnormality of urine glucose concentration (HP:0011016)	1.79688412
112	Elevated alkaline phosphatase (HP:0003155)	1.76706118
113	Abnormality of vitamin metabolism (HP:0100508)	1.76450019
114	Alkalosis (HP:0001948)	1.75983009
115	Epistaxis (HP:0000421)	1.73460874
116	Increased serum pyruvate (HP:0003542)	1.72183102
117	Pulmonary embolism (HP:0002204)	1.72017233
118	Abnormal cartilage morphology (HP:0002763)	1.70568208
119	Abnormality of alkaline phosphatase activity (HP:0004379)	1.65630835
120	Abnormal urine phosphate concentration (HP:0012599)	1.61606560
121	Abnormal delivery (HP:0001787)	1.59785508
122	Potter facies (HP:0002009)	1.52715450
123	Facial shape deformation (HP:0011334)	1.52715450
124	Atrioventricular block (HP:0001678)	1.52711980
125	Impaired platelet aggregation (HP:0003540)	1.51139800
126	Abnormal platelet function (HP:0011869)	1.51139800
127	Abnormal tarsal ossification (HP:0008369)	1.50223962
128	Increased mean platelet volume (HP:0011877)	1.47723585

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	6.63588751
2	ERN1	4.78251439
3	FGFR4	4.69317318
4	SIK1	4.62282645
5	TAOK3	3.26728710
6	INSRR	3.26503744
7	ERBB4	3.25995774
8	MAP2K4	2.37985744
9	MAPK11	2.02762008
10	LATS1	1.89102983
11	MST1R	1.88286609
12	PIK3CG	1.83117049
13	TYK2	1.72740586
14	FLT3	1.61596517
15	PKN2	1.55237161
16	NTRK3	1.53656108
17	NEK9	1.51850164
18	DAPK2	1.41691679
19	PRPF4B	1.37528882
20	MAP3K14	1.36584664
21	TRIB3	1.34372974
22	FRK	1.33918258
23	ABL2	1.33801745
24	PTK6	1.31448794
25	JAK2	1.22370198
26	FGFR2	1.21381809
27	MAP3K2	1.19423134
28	MAP3K7	1.16018212
29	PRKAA2	1.13744913
30	KDR	1.13310142
31	STK38L	1.12238161
32	ERBB2	1.11829579
33	JAK1	1.11552400
34	PINK1	1.09708461
35	TBK1	1.08637536
36	MAP2K3	1.07432631
37	EPHA3	1.07297407
38	TIE1	1.05935065
39	MAPK15	1.05551821
40	MAP3K12	0.99435766
41	MAPK4	0.95548550
42	PDK1	0.93155148
43	PRKCZ	0.91533792
44	GRK6	0.88319470
45	EPHB1	0.88202568
46	CDK12	0.84691973
47	MAPK12	0.82857519
48	PRKG1	0.82855911
49	IRAK3	0.82682697
50	PDGFRA	0.81989408
51	MAPKAPK3	0.80641080
52	EIF2AK1	0.80289528
53	MAP3K3	0.78540919
54	MAP2K6	0.75730903
55	MAP3K11	0.74006421
56	CAMK2G	0.73832817
57	SGK3	0.73321152
58	IKBKE	0.71696395
59	PRKACG	0.70873911
60	CDK6	0.70722808
61	MAPK7	0.70587584
62	SGK2	0.70153591
63	MYLK	0.67274415
64	TGFBR2	0.66501025
65	TNK2	0.66324314
66	CAMK1D	0.66022620
67	FGFR3	0.65896442
68	CSK	0.65599321
69	FER	0.65398880
70	PRKACA	0.65045825
71	SIK3	0.64758203
72	TAOK2	0.64338362
73	FGFR1	0.63768311
74	CSNK1D	0.63277012
75	PRKAA1	0.62294643
76	PKN1	0.61604518
77	MET	0.61241954
78	MAP3K10	0.59972100
79	SGK1	0.59843144
80	MAP3K13	0.59067072
81	GSK3A	0.58385157
82	DYRK1B	0.58096730
83	ZAP70	0.55555323
84	SCYL2	0.55010847
85	KSR2	0.54868271
86	GRK1	0.53847505
87	CSNK1E	0.53725488
88	RPS6KA3	0.51577466
89	MAP3K5	0.51502368
90	WNK4	0.50926690
91	PRKCB	0.50856403
92	CSF1R	0.49470610
93	PRKCQ	0.49030116
94	EPHA4	0.48784050
95	IRAK1	0.48605891
96	CAMKK2	0.48485794
97	ARAF	0.47841788
98	SRC	0.44619735
99	IGF1R	0.44356934
100	CSNK2A2	0.44197442
101	CAMKK1	0.43257390
102	CSNK2A1	0.42294578
103	PDPK1	0.42285700
104	CAMK4	0.42234202
105	MAP3K6	0.41664549
106	SGK494	0.41312457
107	SGK223	0.41312457
108	CSNK1G1	0.40708416
109	STK16	0.40622245
110	PRKACB	0.39160082
111	PRKCG	0.38743522
112	RIPK1	0.38356177
113	AKT3	0.37923611
114	CDK7	0.37049146
115	PTK2	0.36523674
116	CDK4	0.34061432
117	IRAK2	0.34015255
118	MAP2K1	0.33649791
119	SIK2	0.33427283
120	PIK3CA	0.32897594
121	EGFR	0.32046820
122	MAPK3	0.29532308
123	PDK2	0.28947004
124	PBK	0.28729663
125	MTOR	0.27871256
126	RET	0.27107427
127	ICK	0.26455611
128	MAP3K1	0.26155617
129	KIT	0.26066147
130	PRKCA	0.25834874
131	LATS2	0.25799318
132	CAMK1G	0.22805623
133	CHUK	0.22759515
134	ABL1	0.22465777
135	NLK	0.21101795

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.67872598
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.42363483
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.39214549
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.31010869
5	Arginine biosynthesis_Homo sapiens_hsa00220	3.08352508
6	Complement and coagulation cascades_Homo sapiens_hsa04610	2.99194163
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.72086125
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.61945408
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.57762862
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.55060124
11	Fatty acid degradation_Homo sapiens_hsa00071	2.44105443
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.33952700
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.24922589
14	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.12652189
15	Peroxisome_Homo sapiens_hsa04146	2.10639637
16	Butanoate metabolism_Homo sapiens_hsa00650	2.10495077
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.01781149
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.94905128
19	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.92114132
20	Histidine metabolism_Homo sapiens_hsa00340	1.91419936
21	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.90842501
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.86072549
23	Propanoate metabolism_Homo sapiens_hsa00640	1.84828936
24	Caffeine metabolism_Homo sapiens_hsa00232	1.79340008
25	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.78885028
26	Fatty acid metabolism_Homo sapiens_hsa01212	1.73630738
27	Retinol metabolism_Homo sapiens_hsa00830	1.71512752
28	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.71052400
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.70511060
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.69660362
31	Phenylalanine metabolism_Homo sapiens_hsa00360	1.57159688
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.55404116
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.54133624
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.53954040
35	Bile secretion_Homo sapiens_hsa04976	1.48296311
36	Tyrosine metabolism_Homo sapiens_hsa00350	1.46847808
37	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.43104346
38	Sulfur metabolism_Homo sapiens_hsa00920	1.30231537
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.29784889
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.28422388
41	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.27867060
42	Folate biosynthesis_Homo sapiens_hsa00790	1.25895336
43	Fatty acid elongation_Homo sapiens_hsa00062	1.25194296
44	ABC transporters_Homo sapiens_hsa02010	1.22677382
45	Steroid biosynthesis_Homo sapiens_hsa00100	1.16099680
46	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.14249287
47	Fat digestion and absorption_Homo sapiens_hsa04975	1.13345481
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.10452001
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.10089700
50	Carbon metabolism_Homo sapiens_hsa01200	1.04072062
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.98310260
52	Sulfur relay system_Homo sapiens_hsa04122	0.97808748
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.97671859
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.97357648
55	Arginine and proline metabolism_Homo sapiens_hsa00330	0.95170467
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.94060815
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.86373176
58	Lysine degradation_Homo sapiens_hsa00310	0.81095629
59	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.78799014
60	One carbon pool by folate_Homo sapiens_hsa00670	0.75651500
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65026177
62	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.63924080
63	Glutathione metabolism_Homo sapiens_hsa00480	0.60706150
64	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.51065093
65	Pentose phosphate pathway_Homo sapiens_hsa00030	0.51051698
66	Prion diseases_Homo sapiens_hsa05020	0.49167154
67	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47244319
68	Metabolic pathways_Homo sapiens_hsa01100	0.45252715
69	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.32010800
70	Other glycan degradation_Homo sapiens_hsa00511	0.25871086
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.25430834
72	Galactose metabolism_Homo sapiens_hsa00052	0.23362832
73	Insulin resistance_Homo sapiens_hsa04931	0.23172638
74	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.22273373
75	Linoleic acid metabolism_Homo sapiens_hsa00591	0.22122940
76	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.20187102
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.16122601
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.13102671
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.09074495
80	Mineral absorption_Homo sapiens_hsa04978	0.06585288
81	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.2728374
82	Ether lipid metabolism_Homo sapiens_hsa00565	-0.2690720
83	Circadian rhythm_Homo sapiens_hsa04710	-0.2444315
84	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	-0.2392834
85	Renin-angiotensin system_Homo sapiens_hsa04614	-0.2247037
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.2225509
87	Pertussis_Homo sapiens_hsa05133	-0.2181626
88	Amoebiasis_Homo sapiens_hsa05146	-0.2124298
89	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.2095219
90	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	-0.2024366
91	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.2012737
92	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1753465
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.1486524
94	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.1439365
95	Hepatitis C_Homo sapiens_hsa05160	-0.1354691
96	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.1330591
97	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1223714
98	N-Glycan biosynthesis_Homo sapiens_hsa00510	-0.1138581
99	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.1104250
100	Regulation of autophagy_Homo sapiens_hsa04140	-0.0951862
101	African trypanosomiasis_Homo sapiens_hsa05143	-0.0896908
102	Serotonergic synapse_Homo sapiens_hsa04726	-0.0874537
103	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0822656
104	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0698615
105	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.0651711
106	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.0384664
107	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0366819
108	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0025240

SAA4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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