SAA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.11013076
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.56737590
3L-phenylalanine catabolic process (GO:0006559)7.56737590
4epoxygenase P450 pathway (GO:0019373)7.41558351
5L-phenylalanine metabolic process (GO:0006558)7.23835001
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.23835001
7omega-hydroxylase P450 pathway (GO:0097267)7.01210016
8aromatic amino acid family catabolic process (GO:0009074)6.93768288
9indole-containing compound catabolic process (GO:0042436)6.42774072
10indolalkylamine catabolic process (GO:0046218)6.42774072
11tryptophan catabolic process (GO:0006569)6.42774072
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.25615327
13kynurenine metabolic process (GO:0070189)6.23055333
14tryptophan metabolic process (GO:0006568)6.01665461
15bile acid biosynthetic process (GO:0006699)6.00870310
16regulation of plasminogen activation (GO:0010755)5.90166400
17glyoxylate metabolic process (GO:0046487)5.73679584
18complement activation, alternative pathway (GO:0006957)5.72782896
19regulation of protein activation cascade (GO:2000257)5.72130004
20negative regulation of fibrinolysis (GO:0051918)5.66946786
21urea metabolic process (GO:0019627)5.66655945
22urea cycle (GO:0000050)5.66655945
23drug metabolic process (GO:0017144)5.58661754
24protein carboxylation (GO:0018214)5.55205444
25peptidyl-glutamic acid carboxylation (GO:0017187)5.55205444
26high-density lipoprotein particle remodeling (GO:0034375)5.54932374
27regulation of fibrinolysis (GO:0051917)5.52201551
28alpha-linolenic acid metabolic process (GO:0036109)5.40851407
29oxidative demethylation (GO:0070989)5.35503064
30regulation of complement activation (GO:0030449)5.32781641
31nitrogen cycle metabolic process (GO:0071941)5.20293476
32cysteine metabolic process (GO:0006534)5.14522186
33sulfur amino acid catabolic process (GO:0000098)5.14396591
34phenylpropanoid metabolic process (GO:0009698)5.12656749
35bile acid metabolic process (GO:0008206)5.11311519
36serine family amino acid catabolic process (GO:0009071)5.04673856
37aromatic amino acid family metabolic process (GO:0009072)5.02799742
38ethanol metabolic process (GO:0006067)4.95979829
39negative regulation of hemostasis (GO:1900047)4.95838161
40negative regulation of blood coagulation (GO:0030195)4.95838161
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90093455
42regulation of triglyceride catabolic process (GO:0010896)4.86715666
43regulation of cholesterol esterification (GO:0010872)4.86605954
44reverse cholesterol transport (GO:0043691)4.83696176
45tyrosine metabolic process (GO:0006570)4.78835955
46regulation of humoral immune response (GO:0002920)4.73995441
47protein-lipid complex remodeling (GO:0034368)4.73361399
48macromolecular complex remodeling (GO:0034367)4.73361399
49plasma lipoprotein particle remodeling (GO:0034369)4.73361399
50acylglycerol homeostasis (GO:0055090)4.65642536
51triglyceride homeostasis (GO:0070328)4.65642536
52homocysteine metabolic process (GO:0050667)4.63242601
53phospholipid efflux (GO:0033700)4.62668964
54alpha-amino acid catabolic process (GO:1901606)4.62538963
55coenzyme catabolic process (GO:0009109)4.55860359
56indolalkylamine metabolic process (GO:0006586)4.53869932
57lysine metabolic process (GO:0006553)4.53782245
58lysine catabolic process (GO:0006554)4.53782245
59negative regulation of coagulation (GO:0050819)4.52126040
60amino-acid betaine metabolic process (GO:0006577)4.51750058
61negative regulation of sterol transport (GO:0032372)4.51336898
62negative regulation of cholesterol transport (GO:0032375)4.51336898
63amine catabolic process (GO:0009310)4.49024120
64cellular biogenic amine catabolic process (GO:0042402)4.49024120
65negative regulation of wound healing (GO:0061045)4.48530553
66bile acid and bile salt transport (GO:0015721)4.42352492
67imidazole-containing compound metabolic process (GO:0052803)4.36333193
68cellular ketone body metabolic process (GO:0046950)4.30884208
69positive regulation of blood coagulation (GO:0030194)4.30675266
70positive regulation of hemostasis (GO:1900048)4.30675266
71glycine metabolic process (GO:0006544)4.29746487
72plasma lipoprotein particle clearance (GO:0034381)4.27501714
73cellular glucuronidation (GO:0052695)4.26453510
74cellular amino acid catabolic process (GO:0009063)4.22365465
75cholesterol efflux (GO:0033344)4.21938872
76benzene-containing compound metabolic process (GO:0042537)4.17684296
77glutamate metabolic process (GO:0006536)4.17275615
78intestinal cholesterol absorption (GO:0030299)4.13291284
79fibrinolysis (GO:0042730)4.10498170
80S-adenosylmethionine metabolic process (GO:0046500)4.09302194
81serine family amino acid metabolic process (GO:0009069)4.08525913
82complement activation, classical pathway (GO:0006958)4.06578503
83arginine metabolic process (GO:0006525)4.04077831
84positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.01315990
85dicarboxylic acid biosynthetic process (GO:0043650)4.00264976
86disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.99665449
87killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.99665449
88ethanol oxidation (GO:0006069)3.99503470
89cellular modified amino acid catabolic process (GO:0042219)3.98531296
90cytolysis (GO:0019835)3.98513575
91complement activation (GO:0006956)3.97183408
92positive regulation of coagulation (GO:0050820)3.95970645
93negative regulation of complement activation (GO:0045916)3.95915345
94blood coagulation, intrinsic pathway (GO:0007597)3.93269916
95protein activation cascade (GO:0072376)3.93121696
96plasma lipoprotein particle assembly (GO:0034377)3.92853169
97drug catabolic process (GO:0042737)3.90689577
98low-density lipoprotein particle remodeling (GO:0034374)3.90065684
99alkaloid metabolic process (GO:0009820)3.89366384
100serine family amino acid biosynthetic process (GO:0009070)3.88373291
101aldehyde catabolic process (GO:0046185)3.88326077
102cofactor catabolic process (GO:0051187)3.87322875
103negative regulation of lipase activity (GO:0060192)3.81454163
104positive regulation of triglyceride lipase activity (GO:0061365)3.81209540
105positive regulation of lipoprotein lipase activity (GO:0051006)3.81209540
106* acute inflammatory response (GO:0002526)3.79386753
107glucuronate metabolic process (GO:0019585)3.78223546
108uronic acid metabolic process (GO:0006063)3.78223546
109opsonization (GO:0008228)3.77969874
110regulation of bile acid biosynthetic process (GO:0070857)3.77828040
111flavonoid metabolic process (GO:0009812)3.77644085
112hormone catabolic process (GO:0042447)3.76501804
113negative regulation of protein activation cascade (GO:2000258)3.73937031
114very-low-density lipoprotein particle assembly (GO:0034379)3.73816568
115NAD biosynthetic process (GO:0009435)3.73086127
116ketone body metabolic process (GO:1902224)3.72306344
117plasma lipoprotein particle organization (GO:0071827)3.72036095
118positive regulation of lipid catabolic process (GO:0050996)3.69091342
119phospholipid homeostasis (GO:0055091)3.68934331
120cholesterol homeostasis (GO:0042632)3.68710616
121* acute-phase response (GO:0006953)3.68198836
122positive regulation of fatty acid biosynthetic process (GO:0045723)3.67562221
123organic acid catabolic process (GO:0016054)3.66751421
124carboxylic acid catabolic process (GO:0046395)3.66751421
125doxorubicin metabolic process (GO:0044598)3.65447326
126daunorubicin metabolic process (GO:0044597)3.65447326
127polyketide metabolic process (GO:0030638)3.65447326
128regulation of cholesterol homeostasis (GO:2000188)3.63988954
129sterol homeostasis (GO:0055092)3.63033934
130pyridine nucleotide biosynthetic process (GO:0019363)3.61637675
131nicotinamide nucleotide biosynthetic process (GO:0019359)3.61637675
132regulation of lipoprotein particle clearance (GO:0010984)3.60791962
133regulation of apoptotic cell clearance (GO:2000425)3.55191532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.31678412
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.17370389
3PPARA_22158963_ChIP-Seq_LIVER_Mouse7.12369156
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.45024081
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.32399591
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.05917239
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.59776190
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.12135095
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.07837731
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01217896
11* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8577284
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87638204
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81279506
14HTT_18923047_ChIP-ChIP_STHdh_Human1.60993933
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.60392189
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59121036
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.53366882
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.38983227
19GATA1_22025678_ChIP-Seq_K562_Human1.38573216
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37189583
21CLOCK_20551151_ChIP-Seq_293T_Human1.33578233
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26301781
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23400392
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20150597
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18271816
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03941109
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01861857
28IRF8_22096565_ChIP-ChIP_GC-B_Human0.99577763
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99465171
30ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92208998
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85440688
32SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84912991
33AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83441335
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83291638
35KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80781546
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78898165
37GATA4_25053715_ChIP-Seq_YYC3_Human0.76503313
38GATA6_25053715_ChIP-Seq_YYC3_Human0.76306097
39SOX2_21211035_ChIP-Seq_LN229_Human0.74226551
40RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74020549
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74007479
42* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73635519
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72706192
44RARA_24833708_ChIP-Seq_LIVER_Mouse0.70587031
45SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67448908
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67217927
47SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67136416
48RAC3_21632823_ChIP-Seq_H3396_Human0.67005891
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66537514
50NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66537514
51SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66195120
52* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65817317
53SOX2_20726797_ChIP-Seq_SW620_Human0.65713158
54NFE2_27457419_Chip-Seq_LIVER_Mouse0.65429195
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.63511807
56RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62666275
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.62072021
58BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62029968
59SRY_22984422_ChIP-ChIP_TESTIS_Rat0.61803096
60ESR2_21235772_ChIP-Seq_MCF-7_Human0.61598673
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.61285823
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61098310
63HNFA_21074721_ChIP-Seq_CACO-2_Human0.60909159
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.60715406
65CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.60103759
66RARB_24833708_ChIP-Seq_LIVER_Mouse0.59563207
67ELF1_20517297_ChIP-Seq_JURKAT_Human0.59355428
68TAF15_26573619_Chip-Seq_HEK293_Human0.59024600
69DNAJC2_21179169_ChIP-ChIP_NT2_Human0.57254412
70SMC4_20622854_ChIP-Seq_HELA_Human0.56683327
71TP53_18474530_ChIP-ChIP_U2OS_Human0.56181524
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.55916226
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55284347
74AR_20517297_ChIP-Seq_VCAP_Human0.54778949
75SPI1_20517297_ChIP-Seq_HL60_Human0.54433676
76CEBPB_22108803_ChIP-Seq_LS180_Human0.54369472
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.52982534
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.52621666
79STAT1_17558387_ChIP-Seq_HELA_Human0.52514081
80FOXA1_25552417_ChIP-Seq_VCAP_Human0.52320664
81NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.52083604
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.51961887
83ESR1_21235772_ChIP-Seq_MCF-7_Human0.51533321
84CSB_26484114_Chip-Seq_FIBROBLAST_Human0.51405735
85CDX2_20551321_ChIP-Seq_CACO-2_Human0.51341814
86EGR1_19032775_ChIP-ChIP_M12_Human0.51324069
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51087157
88POU5F1_16518401_ChIP-PET_MESCs_Mouse0.51051829
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.51048349
90TCF4_18268006_ChIP-ChIP_LS174T_Human0.50994108
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.50878710
92CBP_21632823_ChIP-Seq_H3396_Human0.50731394
93FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50592687
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.50183641
95MYC_19915707_ChIP-ChIP_AK7_Human0.49700896
96ESET_19884257_ChIP-Seq_ESCs_Mouse0.49673778
97MYC_19829295_ChIP-Seq_ESCs_Human0.49393892
98P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.48584382
99PHF8_20622853_ChIP-Seq_HELA_Human0.48392669
100CTCF_27219007_Chip-Seq_Bcells_Human0.48146240
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.47622008
102SA1_27219007_Chip-Seq_Bcells_Human0.47554048
103PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47482604
104ETV2_25802403_ChIP-Seq_MESCs_Mouse0.47258292
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.47224198
106SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.44991088
107IRF1_19129219_ChIP-ChIP_H3396_Human0.44936394
108ESR1_20079471_ChIP-ChIP_T-47D_Human0.43328380
109BCAT_22108803_ChIP-Seq_LS180_Human0.42828437
110PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42710995
111TAF2_19829295_ChIP-Seq_ESCs_Human0.42475793
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.42318986
113LXR_22292898_ChIP-Seq_THP-1_Human0.42261731
114P53_21459846_ChIP-Seq_SAOS-2_Human0.41583939
115STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40993267
116MYC_27129775_Chip-Seq_CORNEA_Mouse0.40052704
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.39831184
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39643916
119OCT4_21477851_ChIP-Seq_ESCs_Mouse0.39373444
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.38847536
121FOXH1_21741376_ChIP-Seq_EPCs_Human0.38769986
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38335256
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.38289417
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.37456176
125GATA2_19941826_ChIP-Seq_K562_Human0.37377156
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.36958704
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.36909647
128CDX2_22108803_ChIP-Seq_LS180_Human0.36746407
129ZNF263_19887448_ChIP-Seq_K562_Human0.36095256
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.35035879
131ERG_21242973_ChIP-ChIP_JURKAT_Human0.35033731
132GATA1_19941826_ChIP-Seq_K562_Human0.34944123
133SPI1_26923725_Chip-Seq_HPCs_Mouse0.34776909
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.34619883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.31743303
2MP0005360_urolithiasis7.50770259
3MP0005085_abnormal_gallbladder_physiolo6.53124318
4MP0005365_abnormal_bile_salt6.20369559
5MP0008875_abnormal_xenobiotic_pharmacok5.08841757
6MP0003806_abnormal_nucleotide_metabolis4.21432593
7MP0003252_abnormal_bile_duct3.92737614
8MP0010329_abnormal_lipoprotein_level3.59756752
9MP0009840_abnormal_foam_cell3.21676049
10MP0005083_abnormal_biliary_tract3.04074552
11MP0003195_calcinosis2.81854320
12MP0005332_abnormal_amino_acid2.71065454
13MP0001666_abnormal_nutrient_absorption2.58761410
14MP0003191_abnormal_cellular_cholesterol2.49389146
15MP0000609_abnormal_liver_physiology2.15653111
16MP0004019_abnormal_vitamin_homeostasis2.11671784
17MP0002118_abnormal_lipid_homeostasis2.09841996
18MP0003868_abnormal_feces_composition1.97703811
19MP0002138_abnormal_hepatobiliary_system1.93931618
20MP0005319_abnormal_enzyme/_coenzyme1.82886390
21MP0009697_abnormal_copulation1.74224226
22MP0001764_abnormal_homeostasis1.66462616
23MP0005584_abnormal_enzyme/coenzyme_acti1.53173998
24MP0003011_delayed_dark_adaptation1.37110850
25MP0005451_abnormal_body_composition1.35380693
26MP0005647_abnormal_sex_gland1.27467850
27MP0003656_abnormal_erythrocyte_physiolo1.22306969
28MP0003186_abnormal_redox_activity1.20834701
29MP0009643_abnormal_urine_homeostasis1.19223034
30MP0000598_abnormal_liver_morphology1.15604600
31MP0009764_decreased_sensitivity_to1.14911840
32MP0009763_increased_sensitivity_to1.05561230
33MP0003705_abnormal_hypodermis_morpholog1.04520386
34MP0002254_reproductive_system_inflammat1.03408859
35MP0000604_amyloidosis1.02774090
36MP0010368_abnormal_lymphatic_system1.02435149
37MP0001915_intracranial_hemorrhage1.00048272
38MP0005670_abnormal_white_adipose0.98491237
39MP0008469_abnormal_protein_level0.93519833
40MP0005636_abnormal_mineral_homeostasis0.92243653
41MP0009642_abnormal_blood_homeostasis0.87910570
42MP0002876_abnormal_thyroid_physiology0.84056955
43MP0005408_hypopigmentation0.81986970
44MP0009765_abnormal_xenobiotic_induced0.78381185
45MP0005084_abnormal_gallbladder_morpholo0.76764580
46MP0005376_homeostasis/metabolism_phenot0.76712994
47MP0003879_abnormal_hair_cell0.76143899
48MP0002078_abnormal_glucose_homeostasis0.75640327
49MP0005220_abnormal_exocrine_pancreas0.75246398
50MP0006036_abnormal_mitochondrial_physio0.72311271
51MP0002971_abnormal_brown_adipose0.70638233
52MP0005334_abnormal_fat_pad0.70244049
53MP0003690_abnormal_glial_cell0.69007755
54MP0002282_abnormal_trachea_morphology0.67062980
55MP0005535_abnormal_body_temperature0.66401906
56MP0005187_abnormal_penis_morphology0.65713345
57MP0009053_abnormal_anal_canal0.64575981
58MP0005058_abnormal_lysosome_morphology0.62627249
59MP0004130_abnormal_muscle_cell0.61904799
60MP0001661_extended_life_span0.61703876
61MP0000639_abnormal_adrenal_gland0.61536026
62MP0005464_abnormal_platelet_physiology0.59754726
63MP0005266_abnormal_metabolism0.59346569
64MP0004782_abnormal_surfactant_physiolog0.54349529
65MP0002249_abnormal_larynx_morphology0.54319530
66MP0005023_abnormal_wound_healing0.54027576
67MP0003724_increased_susceptibility_to0.52771133
68MP0005448_abnormal_energy_balance0.52151235
69MP0001756_abnormal_urination0.52038182
70MP0009785_altered_susceptibility_to0.51508345
71MP0000566_synostosis0.51342713
72MP0004381_abnormal_hair_follicle0.50172431
73MP0002089_abnormal_postnatal_growth/wei0.49778412
74MP0005395_other_phenotype0.49692785
75MP0006035_abnormal_mitochondrial_morpho0.49239732
76MP0002928_abnormal_bile_duct0.49184728
77MP0003436_decreased_susceptibility_to0.48951710
78MP0002822_catalepsy0.47992845
79MP0003329_amyloid_beta_deposits0.47637010
80MP0005248_abnormal_Harderian_gland0.46105511
81MP0003718_maternal_effect0.45993790
82MP0008874_decreased_physiological_sensi0.45303249
83MP0005166_decreased_susceptibility_to0.45214828
84MP0003638_abnormal_response/metabolism_0.44927541
85MP0002136_abnormal_kidney_physiology0.43422733
86MP0002132_abnormal_respiratory_system0.42235719
87MP0000579_abnormal_nail_morphology0.42121789
88MP0003075_altered_response_to0.40511078
89MP0008873_increased_physiological_sensi0.40374962
90MP0003953_abnormal_hormone_level0.40219416
91MP0006082_CNS_inflammation0.38145434
92MP0005666_abnormal_adipose_tissue0.37313841
93MP0009384_cardiac_valve_regurgitation0.35007466
94MP0003172_abnormal_lysosome_physiology0.34865277
95MP0008872_abnormal_physiological_respon0.33926071
96MP0009115_abnormal_fat_cell0.33338057
97MP0001881_abnormal_mammary_gland0.31977043
98MP0009672_abnormal_birth_weight0.31053598
99MP0000249_abnormal_blood_vessel0.30611114
100MP0002168_other_aberrant_phenotype0.30284688
101MP0002837_dystrophic_cardiac_calcinosis0.30247939
102MP0004883_abnormal_blood_vessel0.30097841
103MP0001845_abnormal_inflammatory_respons0.29918984
104MP0001853_heart_inflammation0.29541853
105MP0002970_abnormal_white_adipose0.28400320
106MP0000230_abnormal_systemic_arterial0.28102880
107MP0002796_impaired_skin_barrier0.28046183
108MP0000427_abnormal_hair_cycle0.27958646
109MP0000467_abnormal_esophagus_morphology0.26499734
110MP0001243_abnormal_dermal_layer0.26476338
111MP0005164_abnormal_response_to0.24678913
112MP0002060_abnormal_skin_morphology0.24291419
113MP0005167_abnormal_blood-brain_barrier0.22539074
114MP0002090_abnormal_vision0.20627275
115MP0000920_abnormal_myelination0.20587897
116MP0005197_abnormal_uvea_morphology0.18274824
117MP0003959_abnormal_lean_body0.18220499
118MP0004272_abnormal_basement_membrane0.17469914
119MP0005377_hearing/vestibular/ear_phenot0.17135255
120MP0003878_abnormal_ear_physiology0.17135255
121MP0002128_abnormal_blood_circulation0.16708816
122MP0003632_abnormal_nervous_system0.16252153

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.47469433
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.37086675
3Intrahepatic cholestasis (HP:0001406)7.34438241
4Prolonged partial thromboplastin time (HP:0003645)6.83095503
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.66685040
6Hypobetalipoproteinemia (HP:0003563)6.27879028
7Xanthomatosis (HP:0000991)6.15358665
8Complement deficiency (HP:0004431)5.98224707
9Hyperlipoproteinemia (HP:0010980)5.61784544
10Joint hemorrhage (HP:0005261)5.01943360
11Abnormality of the common coagulation pathway (HP:0010990)4.74909756
12Hypolipoproteinemia (HP:0010981)4.72073051
13Hyperammonemia (HP:0001987)4.52524009
14Epidermoid cyst (HP:0200040)4.45068884
15Hyperglycinemia (HP:0002154)4.44960408
16Abnormality of complement system (HP:0005339)4.36421209
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.32209640
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.19897186
19Fat malabsorption (HP:0002630)4.19775973
20Abnormality of methionine metabolism (HP:0010901)4.19570276
21Ketosis (HP:0001946)4.18070648
22Hypoalphalipoproteinemia (HP:0003233)4.17514608
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.11023989
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.04573044
25Conjugated hyperbilirubinemia (HP:0002908)3.93089721
26Abnormality of the intrinsic pathway (HP:0010989)3.91142796
27Abnormality of pyrimidine metabolism (HP:0004353)3.89481194
28Abnormality of serine family amino acid metabolism (HP:0010894)3.82941476
29Abnormality of glycine metabolism (HP:0010895)3.82941476
30Hypoglycemic coma (HP:0001325)3.79274902
31Hyperglycinuria (HP:0003108)3.78403710
32Spontaneous abortion (HP:0005268)3.55651080
33Hypercholesterolemia (HP:0003124)3.52643214
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27349339
35Hyperbilirubinemia (HP:0002904)3.25750948
36Steatorrhea (HP:0002570)3.24789491
37Abnormality of fatty-acid metabolism (HP:0004359)3.24264869
38Systemic lupus erythematosus (HP:0002725)3.09497653
39Hypochromic microcytic anemia (HP:0004840)3.08070389
40Myocardial infarction (HP:0001658)3.06253873
41Abnormality of nucleobase metabolism (HP:0010932)3.05559563
42Abnormality of serum amino acid levels (HP:0003112)3.04191042
43Delayed CNS myelination (HP:0002188)3.02120994
44Hepatocellular carcinoma (HP:0001402)2.93682145
45Ketoacidosis (HP:0001993)2.90351445
46Purpura (HP:0000979)2.85431331
47Recurrent gram-negative bacterial infections (HP:0005420)2.78404665
48Metabolic acidosis (HP:0001942)2.71595589
49Skin nodule (HP:0200036)2.68133379
50Vascular calcification (HP:0004934)2.64236299
51Abnormality of purine metabolism (HP:0004352)2.63598748
52Hypoglycemic seizures (HP:0002173)2.59915078
53Glomerulonephritis (HP:0000099)2.57174220
54Mitral stenosis (HP:0001718)2.56245493
55Gingival bleeding (HP:0000225)2.55151098
56Osteomalacia (HP:0002749)2.52726258
57Reduced antithrombin III activity (HP:0001976)2.52495481
58Lethargy (HP:0001254)2.51570712
59Amyloidosis (HP:0011034)2.46172931
60Dicarboxylic aciduria (HP:0003215)2.45642270
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.45642270
62Abnormal gallbladder morphology (HP:0012437)2.37509051
63Spastic diplegia (HP:0001264)2.36910656
64Acanthocytosis (HP:0001927)2.35972511
65Gout (HP:0001997)2.33645837
66Cholelithiasis (HP:0001081)2.33145492
67Cardiovascular calcification (HP:0011915)2.33087369
68Neonatal onset (HP:0003623)2.32887238
69Cerebral edema (HP:0002181)2.28416545
70Cholecystitis (HP:0001082)2.27128377
71Abnormal gallbladder physiology (HP:0012438)2.27128377
72Irritability (HP:0000737)2.26157898
73Thrombophlebitis (HP:0004418)2.25561085
74Menorrhagia (HP:0000132)2.25199128
75Enlarged kidneys (HP:0000105)2.17819859
76Arthropathy (HP:0003040)2.17042011
77Malnutrition (HP:0004395)2.15554598
78Sensorimotor neuropathy (HP:0007141)2.14646779
79Late onset (HP:0003584)2.14432876
80Esophageal varix (HP:0002040)2.13856094
81Pancreatitis (HP:0001733)2.13257965
82Opisthotonus (HP:0002179)2.12473875
83Abnormality of the Achilles tendon (HP:0005109)2.12437163
84Fair hair (HP:0002286)2.09975103
85Brushfield spots (HP:0001088)2.09861419
86Hemorrhage of the eye (HP:0011885)2.05529259
87Hyperinsulinemic hypoglycemia (HP:0000825)2.02501604
88Neonatal hypoglycemia (HP:0001998)2.02176722
89Vomiting (HP:0002013)2.00162959
90Hyperphosphaturia (HP:0003109)1.99254517
91Generalized aminoaciduria (HP:0002909)1.97129403
92Renal cortical cysts (HP:0000803)1.94772311
93Hypophosphatemic rickets (HP:0004912)1.93814105
94Rickets (HP:0002748)1.93524795
95Abnormality of the gallbladder (HP:0005264)1.93388459
96Abnormality of iron homeostasis (HP:0011031)1.93310026
97Poikilocytosis (HP:0004447)1.91686790
98Gangrene (HP:0100758)1.91108428
99Bifid scrotum (HP:0000048)1.90235545
100Increased serum ferritin (HP:0003281)1.90215901
101Abnormality of proline metabolism (HP:0010907)1.90086116
102Hydroxyprolinuria (HP:0003080)1.90086116
103Abnormality of transition element cation homeostasis (HP:0011030)1.88943308
104Joint swelling (HP:0001386)1.88359132
105Abnormal enzyme/coenzyme activity (HP:0012379)1.84065051
106Status epilepticus (HP:0002133)1.83565233
107Elevated hepatic transaminases (HP:0002910)1.83468606
108Hyperglycemia (HP:0003074)1.80721345
109Nephritis (HP:0000123)1.80506799
110Abnormality of urine glucose concentration (HP:0011016)1.79688412
111Glycosuria (HP:0003076)1.79688412
112Elevated alkaline phosphatase (HP:0003155)1.76706118
113Abnormality of vitamin metabolism (HP:0100508)1.76450019
114Alkalosis (HP:0001948)1.75983009
115Epistaxis (HP:0000421)1.73460874
116Increased serum pyruvate (HP:0003542)1.72183102
117Pulmonary embolism (HP:0002204)1.72017233
118Abnormal cartilage morphology (HP:0002763)1.70568208
119Abnormality of alkaline phosphatase activity (HP:0004379)1.65630835
120Abnormal urine phosphate concentration (HP:0012599)1.61606560
121Abnormal delivery (HP:0001787)1.59785508
122Facial shape deformation (HP:0011334)1.52715450
123Potter facies (HP:0002009)1.52715450
124Atrioventricular block (HP:0001678)1.52711980
125Abnormal platelet function (HP:0011869)1.51139800
126Impaired platelet aggregation (HP:0003540)1.51139800
127Abnormal tarsal ossification (HP:0008369)1.50223962
128Increased mean platelet volume (HP:0011877)1.47723585

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.63588751
2ERN14.78251439
3FGFR44.69317318
4SIK14.62282645
5TAOK33.26728710
6INSRR3.26503744
7ERBB43.25995774
8MAP2K42.37985744
9MAPK112.02762008
10LATS11.89102983
11MST1R1.88286609
12PIK3CG1.83117049
13TYK21.72740586
14FLT31.61596517
15PKN21.55237161
16NTRK31.53656108
17NEK91.51850164
18DAPK21.41691679
19PRPF4B1.37528882
20MAP3K141.36584664
21TRIB31.34372974
22FRK1.33918258
23ABL21.33801745
24PTK61.31448794
25JAK21.22370198
26FGFR21.21381809
27MAP3K21.19423134
28MAP3K71.16018212
29PRKAA21.13744913
30KDR1.13310142
31STK38L1.12238161
32ERBB21.11829579
33JAK11.11552400
34PINK11.09708461
35TBK11.08637536
36MAP2K31.07432631
37EPHA31.07297407
38TIE11.05935065
39MAPK151.05551821
40MAP3K120.99435766
41MAPK40.95548550
42PDK10.93155148
43PRKCZ0.91533792
44GRK60.88319470
45EPHB10.88202568
46CDK120.84691973
47MAPK120.82857519
48PRKG10.82855911
49IRAK30.82682697
50PDGFRA0.81989408
51MAPKAPK30.80641080
52EIF2AK10.80289528
53MAP3K30.78540919
54MAP2K60.75730903
55MAP3K110.74006421
56CAMK2G0.73832817
57SGK30.73321152
58IKBKE0.71696395
59PRKACG0.70873911
60CDK60.70722808
61MAPK70.70587584
62SGK20.70153591
63MYLK0.67274415
64TGFBR20.66501025
65TNK20.66324314
66CAMK1D0.66022620
67FGFR30.65896442
68CSK0.65599321
69FER0.65398880
70PRKACA0.65045825
71SIK30.64758203
72TAOK20.64338362
73FGFR10.63768311
74CSNK1D0.63277012
75PRKAA10.62294643
76PKN10.61604518
77MET0.61241954
78MAP3K100.59972100
79SGK10.59843144
80MAP3K130.59067072
81GSK3A0.58385157
82DYRK1B0.58096730
83ZAP700.55555323
84SCYL20.55010847
85KSR20.54868271
86GRK10.53847505
87CSNK1E0.53725488
88RPS6KA30.51577466
89MAP3K50.51502368
90WNK40.50926690
91PRKCB0.50856403
92CSF1R0.49470610
93PRKCQ0.49030116
94EPHA40.48784050
95IRAK10.48605891
96CAMKK20.48485794
97ARAF0.47841788
98SRC0.44619735
99IGF1R0.44356934
100CSNK2A20.44197442
101CAMKK10.43257390
102CSNK2A10.42294578
103PDPK10.42285700
104CAMK40.42234202
105MAP3K60.41664549
106SGK2230.41312457
107SGK4940.41312457
108CSNK1G10.40708416
109STK160.40622245
110PRKACB0.39160082
111PRKCG0.38743522
112RIPK10.38356177
113AKT30.37923611
114CDK70.37049146
115PTK20.36523674
116CDK40.34061432
117IRAK20.34015255
118MAP2K10.33649791
119SIK20.33427283
120PIK3CA0.32897594
121EGFR0.32046820
122MAPK30.29532308
123PDK20.28947004
124PBK0.28729663
125MTOR0.27871256
126RET0.27107427
127ICK0.26455611
128MAP3K10.26155617
129KIT0.26066147
130PRKCA0.25834874
131LATS20.25799318
132CAMK1G0.22805623
133CHUK0.22759515
134ABL10.22465777
135NLK0.21101795

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.67872598
2Nitrogen metabolism_Homo sapiens_hsa009103.42363483
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39214549
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31010869
5Arginine biosynthesis_Homo sapiens_hsa002203.08352508
6Complement and coagulation cascades_Homo sapiens_hsa046102.99194163
7Tryptophan metabolism_Homo sapiens_hsa003802.72086125
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61945408
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57762862
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55060124
11Fatty acid degradation_Homo sapiens_hsa000712.44105443
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33952700
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24922589
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12652189
15Peroxisome_Homo sapiens_hsa041462.10639637
16Butanoate metabolism_Homo sapiens_hsa006502.10495077
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.01781149
18Chemical carcinogenesis_Homo sapiens_hsa052041.94905128
19Staphylococcus aureus infection_Homo sapiens_hsa051501.92114132
20Histidine metabolism_Homo sapiens_hsa003401.91419936
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90842501
22PPAR signaling pathway_Homo sapiens_hsa033201.86072549
23Propanoate metabolism_Homo sapiens_hsa006401.84828936
24Caffeine metabolism_Homo sapiens_hsa002321.79340008
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.78885028
26Fatty acid metabolism_Homo sapiens_hsa012121.73630738
27Retinol metabolism_Homo sapiens_hsa008301.71512752
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71052400
29beta-Alanine metabolism_Homo sapiens_hsa004101.70511060
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69660362
31Phenylalanine metabolism_Homo sapiens_hsa003601.57159688
32Selenocompound metabolism_Homo sapiens_hsa004501.55404116
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54133624
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53954040
35Bile secretion_Homo sapiens_hsa049761.48296311
36Tyrosine metabolism_Homo sapiens_hsa003501.46847808
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43104346
38Sulfur metabolism_Homo sapiens_hsa009201.30231537
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.29784889
40Pyruvate metabolism_Homo sapiens_hsa006201.28422388
41Starch and sucrose metabolism_Homo sapiens_hsa005001.27867060
42Folate biosynthesis_Homo sapiens_hsa007901.25895336
43Fatty acid elongation_Homo sapiens_hsa000621.25194296
44ABC transporters_Homo sapiens_hsa020101.22677382
45Steroid biosynthesis_Homo sapiens_hsa001001.16099680
46Biosynthesis of amino acids_Homo sapiens_hsa012301.14249287
47Fat digestion and absorption_Homo sapiens_hsa049751.13345481
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.10452001
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10089700
50Carbon metabolism_Homo sapiens_hsa012001.04072062
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98310260
52Sulfur relay system_Homo sapiens_hsa041220.97808748
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97671859
54Vitamin B6 metabolism_Homo sapiens_hsa007500.97357648
55Arginine and proline metabolism_Homo sapiens_hsa003300.95170467
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.94060815
57Vitamin digestion and absorption_Homo sapiens_hsa049770.86373176
58Lysine degradation_Homo sapiens_hsa003100.81095629
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78799014
60One carbon pool by folate_Homo sapiens_hsa006700.75651500
61Glycerolipid metabolism_Homo sapiens_hsa005610.65026177
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63924080
63Glutathione metabolism_Homo sapiens_hsa004800.60706150
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51065093
65Pentose phosphate pathway_Homo sapiens_hsa000300.51051698
66Prion diseases_Homo sapiens_hsa050200.49167154
67Fatty acid biosynthesis_Homo sapiens_hsa000610.47244319
68Metabolic pathways_Homo sapiens_hsa011000.45252715
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32010800
70Other glycan degradation_Homo sapiens_hsa005110.25871086
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25430834
72Galactose metabolism_Homo sapiens_hsa000520.23362832
73Insulin resistance_Homo sapiens_hsa049310.23172638
74Fructose and mannose metabolism_Homo sapiens_hsa000510.22273373
75Linoleic acid metabolism_Homo sapiens_hsa005910.22122940
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.20187102
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.16122601
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13102671
79Glucagon signaling pathway_Homo sapiens_hsa049220.09074495
80Mineral absorption_Homo sapiens_hsa049780.06585288
81Type II diabetes mellitus_Homo sapiens_hsa04930-0.2728374
82Ether lipid metabolism_Homo sapiens_hsa00565-0.2690720
83Circadian rhythm_Homo sapiens_hsa04710-0.2444315
84Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2392834
85Renin-angiotensin system_Homo sapiens_hsa04614-0.2247037
86Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2225509
87Pertussis_Homo sapiens_hsa05133-0.2181626
88Amoebiasis_Homo sapiens_hsa05146-0.2124298
89Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2095219
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2024366
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2012737
92Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1753465
93Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1486524
94Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1439365
95Hepatitis C_Homo sapiens_hsa05160-0.1354691
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1330591
97Insulin signaling pathway_Homo sapiens_hsa04910-0.1223714
98N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1138581
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1104250
100Regulation of autophagy_Homo sapiens_hsa04140-0.0951862
101African trypanosomiasis_Homo sapiens_hsa05143-0.0896908
102Serotonergic synapse_Homo sapiens_hsa04726-0.0874537
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0822656
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0698615
105Sphingolipid metabolism_Homo sapiens_hsa00600-0.0651711
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0384664
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0366819
108AMPK signaling pathway_Homo sapiens_hsa04152-0.0025240

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