SAAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.83299711
2DNA replication initiation (GO:0006270)4.81567093
3telomere maintenance via semi-conservative replication (GO:0032201)4.81472850
4DNA strand elongation (GO:0022616)4.65124480
5telomere maintenance via recombination (GO:0000722)4.38689617
6ribosomal small subunit assembly (GO:0000028)4.33217239
7CENP-A containing nucleosome assembly (GO:0034080)4.28044599
8DNA unwinding involved in DNA replication (GO:0006268)4.27074500
9mitotic recombination (GO:0006312)4.26750360
10chromatin remodeling at centromere (GO:0031055)4.22187708
11ribosome assembly (GO:0042255)4.16662845
12DNA replication checkpoint (GO:0000076)4.13149788
13kinetochore organization (GO:0051383)4.05285180
14establishment of viral latency (GO:0019043)3.97177119
15protein localization to kinetochore (GO:0034501)3.95117055
16DNA replication-independent nucleosome organization (GO:0034724)3.93598390
17DNA replication-independent nucleosome assembly (GO:0006336)3.93598390
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.92737764
19maturation of SSU-rRNA (GO:0030490)3.89539771
20negative regulation of ligase activity (GO:0051352)3.85158179
21negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.85158179
22telomere maintenance via telomere lengthening (GO:0010833)3.84717095
23kinetochore assembly (GO:0051382)3.83598381
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82709201
25nucleotide-excision repair, DNA gap filling (GO:0006297)3.76694385
26DNA deamination (GO:0045006)3.65242310
27formation of translation preinitiation complex (GO:0001731)3.61361671
28IMP biosynthetic process (GO:0006188)3.60265427
29DNA replication-dependent nucleosome assembly (GO:0006335)3.60105830
30DNA replication-dependent nucleosome organization (GO:0034723)3.60105830
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.57769580
32nucleobase biosynthetic process (GO:0046112)3.56459218
33ribosomal large subunit biogenesis (GO:0042273)3.53658165
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.53206650
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.52066808
36regulation of mitochondrial translation (GO:0070129)3.51657112
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.50892977
38spliceosomal snRNP assembly (GO:0000387)3.50390931
39mitotic metaphase plate congression (GO:0007080)3.47865000
40mitotic spindle checkpoint (GO:0071174)3.47571780
41cullin deneddylation (GO:0010388)3.47308602
42ribosome biogenesis (GO:0042254)3.45907446
43ribonucleoprotein complex biogenesis (GO:0022613)3.42861261
44regulation of mitotic spindle checkpoint (GO:1903504)3.41978954
45regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41978954
46viral transcription (GO:0019083)3.41072371
47chaperone-mediated protein transport (GO:0072321)3.41066328
48purine nucleobase biosynthetic process (GO:0009113)3.40023225
49regulation of nuclear cell cycle DNA replication (GO:0033262)3.39957114
50sister chromatid segregation (GO:0000819)3.39728319
51histone exchange (GO:0043486)3.37127183
52protein localization to chromosome, centromeric region (GO:0071459)3.37070594
53translational termination (GO:0006415)3.35852929
54positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.33702644
55mitotic nuclear envelope disassembly (GO:0007077)3.30919614
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30318420
57ATP synthesis coupled proton transport (GO:0015986)3.30318420
58DNA damage response, detection of DNA damage (GO:0042769)3.29958656
59meiotic chromosome segregation (GO:0045132)3.29806502
60DNA catabolic process, exonucleolytic (GO:0000738)3.28283969
61ribosomal small subunit biogenesis (GO:0042274)3.27793749
62double-strand break repair via nonhomologous end joining (GO:0006303)3.27121982
63non-recombinational repair (GO:0000726)3.27121982
64DNA double-strand break processing (GO:0000729)3.26874308
65regulation of cellular amino acid metabolic process (GO:0006521)3.26591697
66mismatch repair (GO:0006298)3.25871269
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25339510
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25339510
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25339510
70regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24725833
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22884548
72transcription-coupled nucleotide-excision repair (GO:0006283)3.22498625
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.21647805
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.21647805
75attachment of spindle microtubules to kinetochore (GO:0008608)3.20708624
76protein deneddylation (GO:0000338)3.20216489
77spliceosomal complex assembly (GO:0000245)3.19598299
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.19283777
79viral mRNA export from host cell nucleus (GO:0046784)3.19215023
80positive regulation of ligase activity (GO:0051351)3.17658780
81pseudouridine synthesis (GO:0001522)3.17474702
82signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16818054
83signal transduction involved in DNA damage checkpoint (GO:0072422)3.16818054
84negative regulation of DNA-dependent DNA replication (GO:2000104)3.16179176
85regulation of ubiquitin-protein transferase activity (GO:0051438)3.15484023
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.15200705
87signal transduction involved in cell cycle checkpoint (GO:0072395)3.15125090
88termination of RNA polymerase III transcription (GO:0006386)3.14873866
89transcription elongation from RNA polymerase III promoter (GO:0006385)3.14873866
90regulation of double-strand break repair via homologous recombination (GO:0010569)3.14398386
91telomere maintenance (GO:0000723)3.13920543
92telomere organization (GO:0032200)3.13470252
93intra-S DNA damage checkpoint (GO:0031573)3.12715054
94regulation of sister chromatid segregation (GO:0033045)3.12197803
95regulation of mitotic sister chromatid separation (GO:0010965)3.12197803
96regulation of mitotic sister chromatid segregation (GO:0033047)3.12197803
97regulation of chromosome segregation (GO:0051983)3.10232945
98proteasome assembly (GO:0043248)3.09521642
99rRNA processing (GO:0006364)3.08169880
100metaphase plate congression (GO:0051310)3.07509506
101histone mRNA metabolic process (GO:0008334)3.07257493
102translational elongation (GO:0006414)3.06361976
103regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06043760
104DNA geometric change (GO:0032392)3.05021117
105nuclear pore organization (GO:0006999)3.04541447
106DNA duplex unwinding (GO:0032508)3.04383784
107replication fork processing (GO:0031297)3.03753826
108negative regulation of mitotic sister chromatid separation (GO:2000816)3.03537205
109negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03537205
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03537205
111negative regulation of sister chromatid segregation (GO:0033046)3.03537205
112establishment of integrated proviral latency (GO:0075713)3.03046977
113negative regulation of chromosome segregation (GO:0051985)3.00664394
114translational initiation (GO:0006413)3.00413857
115histone H2A acetylation (GO:0043968)2.99492329
116mitotic sister chromatid segregation (GO:0000070)2.99378708
117IMP metabolic process (GO:0046040)2.98749125
118maturation of 5.8S rRNA (GO:0000460)2.98669093
119spindle checkpoint (GO:0031577)2.97949018
120membrane disassembly (GO:0030397)2.97944909
121nuclear envelope disassembly (GO:0051081)2.97944909
122rRNA modification (GO:0000154)2.97451494
123rRNA metabolic process (GO:0016072)2.97345312
124spindle assembly checkpoint (GO:0071173)2.96644472
125deoxyribonucleotide biosynthetic process (GO:0009263)2.95530569
126somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95519664
127somatic hypermutation of immunoglobulin genes (GO:0016446)2.95519664
128nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.94304020
129RNA splicing, via transesterification reactions (GO:0000375)2.93947276
130DNA ligation (GO:0006266)2.93862841
131RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.93494999
132mRNA splicing, via spliceosome (GO:0000398)2.93494999
133DNA synthesis involved in DNA repair (GO:0000731)2.93120139
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93090918
135negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92384991
136regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92008706
137translesion synthesis (GO:0019985)2.91958914
138chromatin assembly or disassembly (GO:0006333)2.91882262
139base-excision repair (GO:0006284)2.91822617
140postreplication repair (GO:0006301)2.91817359
141regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91423603
142mitotic spindle assembly checkpoint (GO:0007094)2.90972211
143DNA topological change (GO:0006265)2.90541503
144termination of RNA polymerase II transcription (GO:0006369)2.90529279
145nuclear pore complex assembly (GO:0051292)2.90045298
146anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88335864
147ATP-dependent chromatin remodeling (GO:0043044)2.87217865

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.53298268
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34313872
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.19374053
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.04644190
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.39192599
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29079181
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26723008
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.10227166
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94498119
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89487561
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88362950
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.84043445
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83411169
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.69941679
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61754721
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43440850
17XRN2_22483619_ChIP-Seq_HELA_Human2.39135175
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37642230
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35440135
20VDR_23849224_ChIP-Seq_CD4+_Human2.33145427
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31230720
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29828833
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.21399153
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.20737823
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17065481
26FOXP3_21729870_ChIP-Seq_TREG_Human2.15104764
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08152050
28DCP1A_22483619_ChIP-Seq_HELA_Human1.96796433
29* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96715084
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95607565
31TTF2_22483619_ChIP-Seq_HELA_Human1.95076455
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.93366810
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93309359
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93060613
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90385949
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87786767
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85584966
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80682470
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79261377
40CIITA_25753668_ChIP-Seq_RAJI_Human1.79251639
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77044941
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76956487
43ELK1_19687146_ChIP-ChIP_HELA_Human1.76088105
44GABP_19822575_ChIP-Seq_HepG2_Human1.75838886
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75113622
46* YY1_21170310_ChIP-Seq_MESCs_Mouse1.74483253
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74338473
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73807689
49AR_21909140_ChIP-Seq_LNCAP_Human1.69823820
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69822008
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69385665
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66872692
53* SRF_21415370_ChIP-Seq_HL-1_Mouse1.53708714
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.47203870
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47138366
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45780098
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45717517
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41832152
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40788465
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37299071
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36940285
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36869275
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.35837966
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35825135
65* KDM5A_27292631_Chip-Seq_BREAST_Human1.35557485
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31033348
67MYC_22102868_ChIP-Seq_BL_Human1.30877050
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30311363
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23377064
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21675610
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19948348
72EWS_26573619_Chip-Seq_HEK293_Human1.19215486
73ZNF274_21170338_ChIP-Seq_K562_Hela1.15644126
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.14582776
75* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13500681
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10960125
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10204465
78* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09938068
79MYC_18940864_ChIP-ChIP_HL60_Human1.09739930
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04304558
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03185383
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01268166
83SPI1_23547873_ChIP-Seq_NB4_Human1.01076401
84IRF1_19129219_ChIP-ChIP_H3396_Human1.00069669
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99570703
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98482051
87TFEB_21752829_ChIP-Seq_HELA_Human0.97388673
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97086723
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92581880
90SOX17_20123909_ChIP-Seq_XEN_Mouse0.91732499
91FUS_26573619_Chip-Seq_HEK293_Human0.91504711
92KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89855109
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87009070
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86733677
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85635213
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.80586706
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80369512
98VDR_21846776_ChIP-Seq_THP-1_Human0.79971626
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.76694745
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76264101
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.75931256
102IGF1R_20145208_ChIP-Seq_DFB_Human0.75793167
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75184714
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73393851
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.71825462
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70274741
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70242450
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.68202518
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68199462
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.67941179
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.67779335
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67055911
113FLI1_27457419_Chip-Seq_LIVER_Mouse0.63601484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.63206636
2MP0003693_abnormal_embryo_hatching4.56827934
3MP0003111_abnormal_nucleus_morphology4.22173592
4MP0008057_abnormal_DNA_replication4.04655984
5MP0008058_abnormal_DNA_repair3.93570671
6MP0003077_abnormal_cell_cycle3.77475132
7MP0004957_abnormal_blastocyst_morpholog3.69717711
8MP0008007_abnormal_cellular_replicative3.34606664
9MP0002396_abnormal_hematopoietic_system2.67974654
10MP0006292_abnormal_olfactory_placode2.63491970
11MP0008932_abnormal_embryonic_tissue2.50358589
12MP0003123_paternal_imprinting2.29469505
13MP0003786_premature_aging1.99081735
14MP0003806_abnormal_nucleotide_metabolis1.95075665
15MP0006035_abnormal_mitochondrial_morpho1.90467431
16MP0000350_abnormal_cell_proliferation1.87517275
17MP0000490_abnormal_crypts_of1.85848755
18MP0001529_abnormal_vocalization1.85473452
19MP0010030_abnormal_orbit_morphology1.84351564
20MP0009053_abnormal_anal_canal1.82533847
21MP0008877_abnormal_DNA_methylation1.80455741
22MP0006036_abnormal_mitochondrial_physio1.74897842
23MP0001730_embryonic_growth_arrest1.73303462
24MP0003121_genomic_imprinting1.58706396
25MP0001293_anophthalmia1.58592972
26MP0006072_abnormal_retinal_apoptosis1.58374362
27MP0004808_abnormal_hematopoietic_stem1.56660973
28MP0001672_abnormal_embryogenesis/_devel1.51442357
29MP0005380_embryogenesis_phenotype1.51442357
30MP0003763_abnormal_thymus_physiology1.47952957
31MP0001697_abnormal_embryo_size1.46148764
32MP0000313_abnormal_cell_death1.43571636
33MP0000372_irregular_coat_pigmentation1.41840831
34MP0002160_abnormal_reproductive_system1.41819624
35MP0000537_abnormal_urethra_morphology1.39382628
36MP0003136_yellow_coat_color1.37183355
37MP0003984_embryonic_growth_retardation1.36765132
38MP0002085_abnormal_embryonic_tissue1.34429913
39MP0003315_abnormal_perineum_morphology1.33664943
40MP0002088_abnormal_embryonic_growth/wei1.32152966
41MP0010352_gastrointestinal_tract_polyps1.31908680
42MP0002019_abnormal_tumor_incidence1.31135832
43MP0009672_abnormal_birth_weight1.26671606
44MP0002080_prenatal_lethality1.25292015
45MP0000703_abnormal_thymus_morphology1.24904321
46MP0010307_abnormal_tumor_latency1.23711009
47MP0002398_abnormal_bone_marrow1.23569713
48MP0002210_abnormal_sex_determination1.22704278
49MP0003567_abnormal_fetal_cardiomyocyte1.21652092
50MP0008789_abnormal_olfactory_epithelium1.20271798
51MP0002084_abnormal_developmental_patter1.13405277
52MP0003890_abnormal_embryonic-extraembry1.12296617
53MP0001188_hyperpigmentation1.09928197
54MP0004197_abnormal_fetal_growth/weight/1.09391876
55MP0002233_abnormal_nose_morphology1.08111693
56MP0001145_abnormal_male_reproductive1.07175555
57MP0002722_abnormal_immune_system1.07035906
58MP0002086_abnormal_extraembryonic_tissu1.06872284
59MP0009697_abnormal_copulation1.06280871
60MP0000049_abnormal_middle_ear1.03800510
61MP0008995_early_reproductive_senescence1.03697420
62MP0000689_abnormal_spleen_morphology1.02832936
63MP0002132_abnormal_respiratory_system1.02224029
64MP0002095_abnormal_skin_pigmentation1.02032702
65MP0002938_white_spotting1.00443536
66MP0003941_abnormal_skin_development1.00368654
67MP0005389_reproductive_system_phenotype1.00053212
68MP0000647_abnormal_sebaceous_gland1.00009363
69MP0001545_abnormal_hematopoietic_system0.99688320
70MP0005397_hematopoietic_system_phenotyp0.99688320
71MP0005671_abnormal_response_to0.98005017
72MP0009333_abnormal_splenocyte_physiolog0.95762226
73MP0003119_abnormal_digestive_system0.95589297
74MP0001286_abnormal_eye_development0.95167442
75MP0001764_abnormal_homeostasis0.94077860
76MP0001929_abnormal_gametogenesis0.93721998
77MP0002234_abnormal_pharynx_morphology0.93486479
78MP0005253_abnormal_eye_physiology0.92400918
79MP0005075_abnormal_melanosome_morpholog0.92132924
80MP0002429_abnormal_blood_cell0.91635789
81MP0002102_abnormal_ear_morphology0.91562356
82MP0003787_abnormal_imprinting0.91239255
83MP0002090_abnormal_vision0.90715071
84MP0001119_abnormal_female_reproductive0.89967750
85MP0000653_abnormal_sex_gland0.89837124
86MP0003718_maternal_effect0.89677833
87MP0004133_heterotaxia0.89253367
88MP0001835_abnormal_antigen_presentation0.88573720
89MP0003221_abnormal_cardiomyocyte_apopto0.88010205
90MP0002697_abnormal_eye_size0.86572328
91MP0003943_abnormal_hepatobiliary_system0.86463987
92MP0000566_synostosis0.86459696
93MP0002111_abnormal_tail_morphology0.84268769
94MP0000858_altered_metastatic_potential0.84215368
95MP0002751_abnormal_autonomic_nervous0.84073657
96MP0005408_hypopigmentation0.83678855
97MP0000716_abnormal_immune_system0.83598690
98MP0005174_abnormal_tail_pigmentation0.82689078
99MP0005367_renal/urinary_system_phenotyp0.81592507
100MP0000516_abnormal_urinary_system0.81592507
101MP0003186_abnormal_redox_activity0.81278451
102MP0003937_abnormal_limbs/digits/tail_de0.79598741
103MP0005084_abnormal_gallbladder_morpholo0.78516215
104MP0005395_other_phenotype0.76509998
105MP0000015_abnormal_ear_pigmentation0.76253007
106MP0005499_abnormal_olfactory_system0.74279733
107MP0005394_taste/olfaction_phenotype0.74279733
108MP0001800_abnormal_humoral_immune0.74262676
109MP0005391_vision/eye_phenotype0.74175606
110MP0002420_abnormal_adaptive_immunity0.73954918
111MP0009703_decreased_birth_body0.73894964
112MP0001819_abnormal_immune_cell0.72830864
113MP0003698_abnormal_male_reproductive0.72517055
114MP0000358_abnormal_cell_content/0.71999446
115MP0001919_abnormal_reproductive_system0.71362446
116MP0001324_abnormal_eye_pigmentation0.69063373
117MP0002452_abnormal_antigen_presenting0.67406621
118MP0002092_abnormal_eye_morphology0.64582023
119MP0001853_heart_inflammation0.64438925
120MP0002114_abnormal_axial_skeleton0.64156260
121MP0004147_increased_porphyrin_level0.62869090
122MP0002736_abnormal_nociception_after0.62681422
123MP0002075_abnormal_coat/hair_pigmentati0.62357350
124MP0001727_abnormal_embryo_implantation0.62132909
125MP0005384_cellular_phenotype0.61822992
126MP0003942_abnormal_urinary_system0.60263904
127MP0003861_abnormal_nervous_system0.58314694
128MP0002161_abnormal_fertility/fecundity0.57282947
129MP0003755_abnormal_palate_morphology0.49931717
130MP0009379_abnormal_foot_pigmentation0.49704347
131MP0002163_abnormal_gland_morphology0.46134144
132MP0005187_abnormal_penis_morphology0.45917924

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.53876829
2Acute necrotizing encephalopathy (HP:0006965)3.92909938
3Breast hypoplasia (HP:0003187)3.88229165
4Reticulocytopenia (HP:0001896)3.85580039
5Chromsome breakage (HP:0040012)3.85298120
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75950511
7Abnormal mitochondria in muscle tissue (HP:0008316)3.68326531
8Aplastic anemia (HP:0001915)3.59395632
9Acute encephalopathy (HP:0006846)3.57701135
10Mitochondrial inheritance (HP:0001427)3.35374279
11Increased CSF lactate (HP:0002490)3.31841079
12Abnormality of cells of the erythroid lineage (HP:0012130)3.23876023
13Patellar aplasia (HP:0006443)3.19379609
14Increased hepatocellular lipid droplets (HP:0006565)3.18633918
15Increased serum pyruvate (HP:0003542)3.17367357
16Abnormal number of erythroid precursors (HP:0012131)3.15131556
17Hepatocellular necrosis (HP:0001404)3.14805959
18Progressive macrocephaly (HP:0004481)3.14803485
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.14158547
20Abnormal number of incisors (HP:0011064)3.08613170
21Abnormality of the preputium (HP:0100587)3.07003618
22Selective tooth agenesis (HP:0001592)3.04292554
23Colon cancer (HP:0003003)3.02616173
24Abnormality of glycolysis (HP:0004366)3.02194862
25Meckel diverticulum (HP:0002245)3.02043716
26Aplasia/Hypoplasia of the patella (HP:0006498)3.01463984
27Cerebral edema (HP:0002181)2.95602092
28Lipid accumulation in hepatocytes (HP:0006561)2.93965392
29Abnormality of the ileum (HP:0001549)2.90313043
30Hepatic necrosis (HP:0002605)2.89446903
31Microvesicular hepatic steatosis (HP:0001414)2.84731302
32Abnormality of chromosome stability (HP:0003220)2.83770110
33Abnormal lung lobation (HP:0002101)2.77123973
34Myelodysplasia (HP:0002863)2.75967259
35Increased serum lactate (HP:0002151)2.69746124
36Oral leukoplakia (HP:0002745)2.68469231
37Absent thumb (HP:0009777)2.65336723
38Bone marrow hypocellularity (HP:0005528)2.63281942
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.60218002
40Abnormal protein N-linked glycosylation (HP:0012347)2.60218002
41Abnormal protein glycosylation (HP:0012346)2.60218002
42Abnormal glycosylation (HP:0012345)2.60218002
43Pallor (HP:0000980)2.52983152
44Abnormality of the anterior horn cell (HP:0006802)2.52973492
45Degeneration of anterior horn cells (HP:0002398)2.52973492
46Supernumerary spleens (HP:0009799)2.50849315
47Premature graying of hair (HP:0002216)2.45380459
48Hyperglycinemia (HP:0002154)2.45179859
49Small intestinal stenosis (HP:0012848)2.44997436
50Duodenal stenosis (HP:0100867)2.44997436
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43479542
52Medulloblastoma (HP:0002885)2.41568453
53Lactic acidosis (HP:0003128)2.41483016
54Abnormality of methionine metabolism (HP:0010901)2.41008608
55Abnormality of the labia minora (HP:0012880)2.40173428
56Macrocytic anemia (HP:0001972)2.38444255
57Nephroblastoma (Wilms tumor) (HP:0002667)2.35727144
58Multiple enchondromatosis (HP:0005701)2.35669590
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31729578
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31729578
61Reduced antithrombin III activity (HP:0001976)2.28238519
62Ectopic kidney (HP:0000086)2.27059228
63Short middle phalanx of the 5th finger (HP:0004220)2.26213431
64Cortical dysplasia (HP:0002539)2.25196072
65Rough bone trabeculation (HP:0100670)2.24559078
66Abnormality of serum amino acid levels (HP:0003112)2.22887636
67Exercise intolerance (HP:0003546)2.20468785
68Impulsivity (HP:0100710)2.19395741
69Agnosia (HP:0010524)2.19372833
70Sloping forehead (HP:0000340)2.19133609
71Increased intramyocellular lipid droplets (HP:0012240)2.17607287
72Optic nerve coloboma (HP:0000588)2.16963678
73Embryonal renal neoplasm (HP:0011794)2.16654416
74Triphalangeal thumb (HP:0001199)2.15430532
75IgM deficiency (HP:0002850)2.13684991
76Abnormality of the carotid arteries (HP:0005344)2.12782226
77Methylmalonic acidemia (HP:0002912)2.12169863
78Cellular immunodeficiency (HP:0005374)2.11030792
79Increased nuchal translucency (HP:0010880)2.10371145
80Renal Fanconi syndrome (HP:0001994)2.10333739
81Carpal bone hypoplasia (HP:0001498)2.09539617
82Tracheoesophageal fistula (HP:0002575)2.08975087
83Absent radius (HP:0003974)2.07736246
84Pancreatic islet-cell hyperplasia (HP:0004510)2.06993760
85Horseshoe kidney (HP:0000085)2.06843514
86Leukodystrophy (HP:0002415)2.06090360
87Duplicated collecting system (HP:0000081)2.06042826
88Clubbing of toes (HP:0100760)2.05776514
89Abnormality of the duodenum (HP:0002246)2.05589010
90Pancytopenia (HP:0001876)2.05290484
9111 pairs of ribs (HP:0000878)2.04478789
92Atresia of the external auditory canal (HP:0000413)2.03912495
93Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01411251
94Cleft eyelid (HP:0000625)1.99220319
95Spastic diplegia (HP:0001264)1.99041793
96Ependymoma (HP:0002888)1.98728204
973-Methylglutaconic aciduria (HP:0003535)1.96617339
98Abnormality of glycine metabolism (HP:0010895)1.96531309
99Abnormality of serine family amino acid metabolism (HP:0010894)1.96531309
100Abnormality of the heme biosynthetic pathway (HP:0010472)1.96486064
101Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95414711
102Short 4th metacarpal (HP:0010044)1.95414711
103Rhabdomyosarcoma (HP:0002859)1.95388323
104Abnormality of the incisor (HP:0000676)1.95385926
105Abnormality of the renal collecting system (HP:0004742)1.95035085
106Microretrognathia (HP:0000308)1.94301304
107Respiratory failure (HP:0002878)1.92755152
108Absent forearm bone (HP:0003953)1.92269622
109Aplasia involving forearm bones (HP:0009822)1.92269622
110Cerebral hypomyelination (HP:0006808)1.92247174
111Neoplasm of the pancreas (HP:0002894)1.92064225
112Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91354506
113Respiratory difficulties (HP:0002880)1.89696011
114Postnatal microcephaly (HP:0005484)1.89175621
115Methylmalonic aciduria (HP:0012120)1.89062379
116Volvulus (HP:0002580)1.88559029
117Hyperalaninemia (HP:0003348)1.86787622
118Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86787622
119Abnormality of alanine metabolism (HP:0010916)1.86787622
120Neoplasm of the colon (HP:0100273)1.86170688
121Lethargy (HP:0001254)1.85659888
122Abnormality of the columella (HP:0009929)1.84228855
123Pancreatic cysts (HP:0001737)1.84137396
124Hypoplasia of the pons (HP:0012110)1.83659153
125Abnormality of DNA repair (HP:0003254)1.83349262
126Abnormality of the pons (HP:0007361)1.82900711
127Type I transferrin isoform profile (HP:0003642)1.82412768
128Asplenia (HP:0001746)1.81219226
129Lymphoma (HP:0002665)1.79378444
130Deviation of the thumb (HP:0009603)1.78295155
131Megaloblastic anemia (HP:0001889)1.78074601
132Squamous cell carcinoma (HP:0002860)1.77698399
133Proximal placement of thumb (HP:0009623)1.77564151
134Thrombocytosis (HP:0001894)1.75700016
135Facial cleft (HP:0002006)1.75696446
136Neoplasm of the oral cavity (HP:0100649)1.75329341
137Optic disc pallor (HP:0000543)1.75091092
138Slender long bone (HP:0003100)1.74758131
139Hyperglycinuria (HP:0003108)1.72836333
140Facial hemangioma (HP:0000329)1.71662491
141Short thumb (HP:0009778)1.69975130
142Hypoplastic labia majora (HP:0000059)1.69761101
143Renal duplication (HP:0000075)1.69187601
144IgG deficiency (HP:0004315)1.65296661
145Bifid tongue (HP:0010297)1.65174066
146Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65150045
147Muscle fiber atrophy (HP:0100295)1.64655454
148Long eyelashes (HP:0000527)1.62882828
149Mesomelia (HP:0003027)1.62441920
150Abnormal hair whorl (HP:0010721)1.61696102
151Secondary amenorrhea (HP:0000869)1.59977660
152Aplasia/Hypoplasia of the spleen (HP:0010451)1.59893120
153Intestinal atresia (HP:0011100)1.59886195
154Hypoplasia of the radius (HP:0002984)1.58397078
155Pendular nystagmus (HP:0012043)1.58248455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.04328378
2WEE13.95233997
3BUB13.94884379
4VRK23.67569163
5TLK13.19451861
6STK162.94948654
7SRPK12.87330164
8PLK42.84529916
9EIF2AK12.84080010
10NEK22.64889071
11MKNK12.36107145
12TRIM282.33481893
13NME22.33339387
14VRK12.18720188
15MKNK22.10708777
16ACVR1B2.07453826
17MST42.03172807
18NUAK11.98186734
19PLK11.94348044
20TESK21.86286765
21ATR1.85811612
22TTK1.84034107
23ZAK1.83012556
24TSSK61.82518128
25BRSK21.80451003
26PASK1.79145285
27CDK71.76922475
28WNK31.67242785
29EIF2AK31.65553194
30BCKDK1.64253099
31CCNB11.63988722
32PLK31.62111342
33TAF11.57588340
34AURKB1.54077721
35BRD41.51171638
36TNIK1.50283825
37RPS6KA41.43465776
38TAOK21.37622470
39DYRK31.37566771
40NME11.37246557
41MAP4K21.33040549
42CHEK21.26829185
43EIF2AK21.23604762
44BCR1.18050327
45BRSK11.15002420
46TGFBR11.12641776
47MAP4K11.07466878
48CDK81.06573070
49RPS6KB21.05768287
50CHEK11.03962550
51AURKA1.03909625
52CSNK1G30.98147510
53PIM20.95895404
54CSNK1G10.95741022
55PDK20.95092176
56NEK10.93812552
57TXK0.92648571
58ATM0.91657824
59CLK10.91399244
60FLT30.89360245
61BTK0.88013991
62YES10.87844193
63PIM10.86716035
64ERBB30.85584137
65STK40.84561149
66CDK40.84498972
67IRAK40.81625048
68MAP3K80.80977388
69PAK40.80392749
70CDK120.79266828
71CSNK1A1L0.77143865
72CDK20.76058992
73CSNK1G20.72973641
74PLK20.72037932
75MAP3K110.71424252
76TEC0.70836433
77KDR0.68756684
78BRAF0.67245704
79CSNK2A10.67132228
80RPS6KC10.63918946
81RPS6KL10.63918946
82RPS6KA50.62501706
83SIK30.62105437
84RPS6KA60.61593940
85ERBB40.61206520
86MAP2K70.60891135
87CDK10.60393988
88KIT0.60187585
89CSNK2A20.59635207
90BMPR1B0.59618961
91ALK0.59134683
92MAP3K40.58369829
93MAP3K120.55915559
94DYRK20.55783818
95AKT30.52946702
96EPHA20.51873878
97PBK0.48950429
98EPHB20.47972099
99STK100.47813620
100PNCK0.47803468
101ICK0.47689811
102SCYL20.46708546
103CDK190.44102558
104LYN0.43986834
105DAPK10.42994267
106CDK90.41782473
107TAOK30.41770188
108MELK0.41279952
109CHUK0.40948008
110MAP2K30.40477813
111STK30.40403032
112RPS6KB10.40401739
113PRKCI0.37707647
114PAK10.37278218
115CSNK1E0.36596355
116IRAK30.36380662
117CSF1R0.36062312
118IKBKB0.36007869
119STK38L0.34618166
120CDK30.34167740
121LIMK10.33657715
122GRK10.33536478
123BLK0.33160399
124CDK140.31729867
125AKT20.31359339
126FGFR10.30300144
127CDK180.29909678
128ILK0.29640306
129TESK10.26879285
130AKT10.26274278
131MAPKAPK50.25937787
132CDK11A0.25592019
133SYK0.24924024
134PRKDC0.23816046
135ZAP700.23012440
136MAP3K50.22992273
137RPS6KA10.21503478

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.16632635
2Mismatch repair_Homo sapiens_hsa034304.33129764
3Base excision repair_Homo sapiens_hsa034103.41792807
4Ribosome_Homo sapiens_hsa030103.39434708
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31576127
6Spliceosome_Homo sapiens_hsa030403.30113838
7RNA polymerase_Homo sapiens_hsa030203.28181879
8Homologous recombination_Homo sapiens_hsa034403.27550518
9Proteasome_Homo sapiens_hsa030503.15920163
10Nucleotide excision repair_Homo sapiens_hsa034202.85788037
11RNA transport_Homo sapiens_hsa030132.80558205
12Cell cycle_Homo sapiens_hsa041102.67153911
13Pyrimidine metabolism_Homo sapiens_hsa002402.59685286
14Fanconi anemia pathway_Homo sapiens_hsa034602.58552981
15One carbon pool by folate_Homo sapiens_hsa006702.41485133
16Non-homologous end-joining_Homo sapiens_hsa034502.39130986
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21301052
18Basal transcription factors_Homo sapiens_hsa030221.93392261
19RNA degradation_Homo sapiens_hsa030181.88457192
20mRNA surveillance pathway_Homo sapiens_hsa030151.73958919
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54397737
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49800964
23p53 signaling pathway_Homo sapiens_hsa041151.49708671
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48768758
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47169232
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45443989
27Purine metabolism_Homo sapiens_hsa002301.42967955
28Propanoate metabolism_Homo sapiens_hsa006401.41290346
29Fatty acid elongation_Homo sapiens_hsa000621.36810147
30Pyruvate metabolism_Homo sapiens_hsa006201.33778362
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30784987
32Systemic lupus erythematosus_Homo sapiens_hsa053221.30602044
33Alzheimers disease_Homo sapiens_hsa050101.29996067
34Epstein-Barr virus infection_Homo sapiens_hsa051691.23849688
35Steroid biosynthesis_Homo sapiens_hsa001001.20736837
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20578708
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15424033
38Herpes simplex infection_Homo sapiens_hsa051681.15163082
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11621572
40Carbon metabolism_Homo sapiens_hsa012001.08615379
41Primary immunodeficiency_Homo sapiens_hsa053401.01439356
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97578014
43Caffeine metabolism_Homo sapiens_hsa002320.97554049
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90768661
45Viral carcinogenesis_Homo sapiens_hsa052030.85633736
46Antigen processing and presentation_Homo sapiens_hsa046120.81927373
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79564442
48Oocyte meiosis_Homo sapiens_hsa041140.74607625
49HTLV-I infection_Homo sapiens_hsa051660.73772642
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70873351
51Protein export_Homo sapiens_hsa030600.70831317
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68518088
53Measles_Homo sapiens_hsa051620.65335504
54Pentose phosphate pathway_Homo sapiens_hsa000300.63571676
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.63170825
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61309746
57Legionellosis_Homo sapiens_hsa051340.61077520
58Huntingtons disease_Homo sapiens_hsa050160.60649747
59Allograft rejection_Homo sapiens_hsa053300.60083195
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59530988
61Cardiac muscle contraction_Homo sapiens_hsa042600.58614175
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.57172680
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.53934278
64Butanoate metabolism_Homo sapiens_hsa006500.51941123
65Alcoholism_Homo sapiens_hsa050340.51591038
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51389014
67Peroxisome_Homo sapiens_hsa041460.51344270
68Fatty acid metabolism_Homo sapiens_hsa012120.50848659
69Small cell lung cancer_Homo sapiens_hsa052220.49675724
70MicroRNAs in cancer_Homo sapiens_hsa052060.49154837
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.47104519
72Colorectal cancer_Homo sapiens_hsa052100.46887209
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46680315
74Apoptosis_Homo sapiens_hsa042100.46150936
75Hepatitis B_Homo sapiens_hsa051610.46149308
76Notch signaling pathway_Homo sapiens_hsa043300.44964429
77Basal cell carcinoma_Homo sapiens_hsa052170.44283484
78N-Glycan biosynthesis_Homo sapiens_hsa005100.44008046
79Thyroid cancer_Homo sapiens_hsa052160.43612901
80Hematopoietic cell lineage_Homo sapiens_hsa046400.43289230
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43177881
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42792482
83Folate biosynthesis_Homo sapiens_hsa007900.42181871
84Influenza A_Homo sapiens_hsa051640.41764979
85Selenocompound metabolism_Homo sapiens_hsa004500.40635823
86Asthma_Homo sapiens_hsa053100.36442382
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35571467
88Graft-versus-host disease_Homo sapiens_hsa053320.33541883
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33496368
90Parkinsons disease_Homo sapiens_hsa050120.33455175
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32069609
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30869462
93Glutathione metabolism_Homo sapiens_hsa004800.30550186
94Arginine and proline metabolism_Homo sapiens_hsa003300.30397276
95Autoimmune thyroid disease_Homo sapiens_hsa053200.30024637
96Tryptophan metabolism_Homo sapiens_hsa003800.29812811
97TGF-beta signaling pathway_Homo sapiens_hsa043500.28993230
98beta-Alanine metabolism_Homo sapiens_hsa004100.28566555
99Sulfur metabolism_Homo sapiens_hsa009200.27595791
100Fatty acid degradation_Homo sapiens_hsa000710.27574558
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27474001
102Viral myocarditis_Homo sapiens_hsa054160.25830020
103Leishmaniasis_Homo sapiens_hsa051400.25445406
104Vitamin B6 metabolism_Homo sapiens_hsa007500.25177694
105Pathways in cancer_Homo sapiens_hsa052000.24915160
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24843158
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24709170
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24346909
109Shigellosis_Homo sapiens_hsa051310.23733997
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22955591
111Hippo signaling pathway_Homo sapiens_hsa043900.22740574
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.22576428
113Acute myeloid leukemia_Homo sapiens_hsa052210.22289841
114Sulfur relay system_Homo sapiens_hsa041220.21323992
115Hedgehog signaling pathway_Homo sapiens_hsa043400.20496272
116Chronic myeloid leukemia_Homo sapiens_hsa052200.19936384
117Lysine degradation_Homo sapiens_hsa003100.18858901
118B cell receptor signaling pathway_Homo sapiens_hsa046620.18394359
119Biosynthesis of amino acids_Homo sapiens_hsa012300.18211623
120T cell receptor signaling pathway_Homo sapiens_hsa046600.17887312
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16245986
122Prostate cancer_Homo sapiens_hsa052150.16223819
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15034200
124Wnt signaling pathway_Homo sapiens_hsa043100.14941156
125Phototransduction_Homo sapiens_hsa047440.14281825
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.14252575
127Fructose and mannose metabolism_Homo sapiens_hsa000510.13829454
128HIF-1 signaling pathway_Homo sapiens_hsa040660.13239079
129Metabolic pathways_Homo sapiens_hsa011000.12905214
130Arachidonic acid metabolism_Homo sapiens_hsa005900.10912685
131Melanoma_Homo sapiens_hsa052180.10886868
132Galactose metabolism_Homo sapiens_hsa000520.10617943
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10460248
134Oxidative phosphorylation_Homo sapiens_hsa001900.10060097
135Regulation of autophagy_Homo sapiens_hsa041400.08649194
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06807298
137Vitamin digestion and absorption_Homo sapiens_hsa049770.04447266
138Tyrosine metabolism_Homo sapiens_hsa003500.02428741
139Retinol metabolism_Homo sapiens_hsa008300.01936542

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