

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.83299711 |
| 2 | DNA replication initiation (GO:0006270) | 4.81567093 |
| 3 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.81472850 |
| 4 | DNA strand elongation (GO:0022616) | 4.65124480 |
| 5 | telomere maintenance via recombination (GO:0000722) | 4.38689617 |
| 6 | ribosomal small subunit assembly (GO:0000028) | 4.33217239 |
| 7 | CENP-A containing nucleosome assembly (GO:0034080) | 4.28044599 |
| 8 | DNA unwinding involved in DNA replication (GO:0006268) | 4.27074500 |
| 9 | mitotic recombination (GO:0006312) | 4.26750360 |
| 10 | chromatin remodeling at centromere (GO:0031055) | 4.22187708 |
| 11 | ribosome assembly (GO:0042255) | 4.16662845 |
| 12 | DNA replication checkpoint (GO:0000076) | 4.13149788 |
| 13 | kinetochore organization (GO:0051383) | 4.05285180 |
| 14 | establishment of viral latency (GO:0019043) | 3.97177119 |
| 15 | protein localization to kinetochore (GO:0034501) | 3.95117055 |
| 16 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.93598390 |
| 17 | DNA replication-independent nucleosome organization (GO:0034724) | 3.93598390 |
| 18 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.92737764 |
| 19 | maturation of SSU-rRNA (GO:0030490) | 3.89539771 |
| 20 | negative regulation of ligase activity (GO:0051352) | 3.85158179 |
| 21 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.85158179 |
| 22 | telomere maintenance via telomere lengthening (GO:0010833) | 3.84717095 |
| 23 | kinetochore assembly (GO:0051382) | 3.83598381 |
| 24 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.82709201 |
| 25 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.76694385 |
| 26 | DNA deamination (GO:0045006) | 3.65242310 |
| 27 | formation of translation preinitiation complex (GO:0001731) | 3.61361671 |
| 28 | IMP biosynthetic process (GO:0006188) | 3.60265427 |
| 29 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.60105830 |
| 30 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.60105830 |
| 31 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.57769580 |
| 32 | nucleobase biosynthetic process (GO:0046112) | 3.56459218 |
| 33 | ribosomal large subunit biogenesis (GO:0042273) | 3.53658165 |
| 34 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.53206650 |
| 35 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.52066808 |
| 36 | regulation of mitochondrial translation (GO:0070129) | 3.51657112 |
| 37 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.50892977 |
| 38 | spliceosomal snRNP assembly (GO:0000387) | 3.50390931 |
| 39 | mitotic metaphase plate congression (GO:0007080) | 3.47865000 |
| 40 | mitotic spindle checkpoint (GO:0071174) | 3.47571780 |
| 41 | cullin deneddylation (GO:0010388) | 3.47308602 |
| 42 | ribosome biogenesis (GO:0042254) | 3.45907446 |
| 43 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.42861261 |
| 44 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.41978954 |
| 45 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.41978954 |
| 46 | viral transcription (GO:0019083) | 3.41072371 |
| 47 | chaperone-mediated protein transport (GO:0072321) | 3.41066328 |
| 48 | purine nucleobase biosynthetic process (GO:0009113) | 3.40023225 |
| 49 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.39957114 |
| 50 | sister chromatid segregation (GO:0000819) | 3.39728319 |
| 51 | histone exchange (GO:0043486) | 3.37127183 |
| 52 | protein localization to chromosome, centromeric region (GO:0071459) | 3.37070594 |
| 53 | translational termination (GO:0006415) | 3.35852929 |
| 54 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.33702644 |
| 55 | mitotic nuclear envelope disassembly (GO:0007077) | 3.30919614 |
| 56 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.30318420 |
| 57 | ATP synthesis coupled proton transport (GO:0015986) | 3.30318420 |
| 58 | DNA damage response, detection of DNA damage (GO:0042769) | 3.29958656 |
| 59 | meiotic chromosome segregation (GO:0045132) | 3.29806502 |
| 60 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.28283969 |
| 61 | ribosomal small subunit biogenesis (GO:0042274) | 3.27793749 |
| 62 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.27121982 |
| 63 | non-recombinational repair (GO:0000726) | 3.27121982 |
| 64 | DNA double-strand break processing (GO:0000729) | 3.26874308 |
| 65 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.26591697 |
| 66 | mismatch repair (GO:0006298) | 3.25871269 |
| 67 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.25339510 |
| 68 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.25339510 |
| 69 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.25339510 |
| 70 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.24725833 |
| 71 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.22884548 |
| 72 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.22498625 |
| 73 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.21647805 |
| 74 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.21647805 |
| 75 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.20708624 |
| 76 | protein deneddylation (GO:0000338) | 3.20216489 |
| 77 | spliceosomal complex assembly (GO:0000245) | 3.19598299 |
| 78 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.19283777 |
| 79 | viral mRNA export from host cell nucleus (GO:0046784) | 3.19215023 |
| 80 | positive regulation of ligase activity (GO:0051351) | 3.17658780 |
| 81 | pseudouridine synthesis (GO:0001522) | 3.17474702 |
| 82 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.16818054 |
| 83 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.16818054 |
| 84 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.16179176 |
| 85 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.15484023 |
| 86 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.15200705 |
| 87 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.15125090 |
| 88 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.14873866 |
| 89 | termination of RNA polymerase III transcription (GO:0006386) | 3.14873866 |
| 90 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.14398386 |
| 91 | telomere maintenance (GO:0000723) | 3.13920543 |
| 92 | telomere organization (GO:0032200) | 3.13470252 |
| 93 | intra-S DNA damage checkpoint (GO:0031573) | 3.12715054 |
| 94 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.12197803 |
| 95 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.12197803 |
| 96 | regulation of sister chromatid segregation (GO:0033045) | 3.12197803 |
| 97 | regulation of chromosome segregation (GO:0051983) | 3.10232945 |
| 98 | proteasome assembly (GO:0043248) | 3.09521642 |
| 99 | rRNA processing (GO:0006364) | 3.08169880 |
| 100 | metaphase plate congression (GO:0051310) | 3.07509506 |
| 101 | histone mRNA metabolic process (GO:0008334) | 3.07257493 |
| 102 | translational elongation (GO:0006414) | 3.06361976 |
| 103 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.06043760 |
| 104 | DNA geometric change (GO:0032392) | 3.05021117 |
| 105 | nuclear pore organization (GO:0006999) | 3.04541447 |
| 106 | DNA duplex unwinding (GO:0032508) | 3.04383784 |
| 107 | replication fork processing (GO:0031297) | 3.03753826 |
| 108 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.03537205 |
| 109 | negative regulation of sister chromatid segregation (GO:0033046) | 3.03537205 |
| 110 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.03537205 |
| 111 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.03537205 |
| 112 | establishment of integrated proviral latency (GO:0075713) | 3.03046977 |
| 113 | negative regulation of chromosome segregation (GO:0051985) | 3.00664394 |
| 114 | translational initiation (GO:0006413) | 3.00413857 |
| 115 | histone H2A acetylation (GO:0043968) | 2.99492329 |
| 116 | mitotic sister chromatid segregation (GO:0000070) | 2.99378708 |
| 117 | IMP metabolic process (GO:0046040) | 2.98749125 |
| 118 | maturation of 5.8S rRNA (GO:0000460) | 2.98669093 |
| 119 | spindle checkpoint (GO:0031577) | 2.97949018 |
| 120 | membrane disassembly (GO:0030397) | 2.97944909 |
| 121 | nuclear envelope disassembly (GO:0051081) | 2.97944909 |
| 122 | rRNA modification (GO:0000154) | 2.97451494 |
| 123 | rRNA metabolic process (GO:0016072) | 2.97345312 |
| 124 | spindle assembly checkpoint (GO:0071173) | 2.96644472 |
| 125 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.95530569 |
| 126 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.95519664 |
| 127 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.95519664 |
| 128 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.94304020 |
| 129 | RNA splicing, via transesterification reactions (GO:0000375) | 2.93947276 |
| 130 | DNA ligation (GO:0006266) | 2.93862841 |
| 131 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.93494999 |
| 132 | mRNA splicing, via spliceosome (GO:0000398) | 2.93494999 |
| 133 | DNA synthesis involved in DNA repair (GO:0000731) | 2.93120139 |
| 134 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.93090918 |
| 135 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.92384991 |
| 136 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.92008706 |
| 137 | translesion synthesis (GO:0019985) | 2.91958914 |
| 138 | chromatin assembly or disassembly (GO:0006333) | 2.91882262 |
| 139 | base-excision repair (GO:0006284) | 2.91822617 |
| 140 | postreplication repair (GO:0006301) | 2.91817359 |
| 141 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.91423603 |
| 142 | mitotic spindle assembly checkpoint (GO:0007094) | 2.90972211 |
| 143 | DNA topological change (GO:0006265) | 2.90541503 |
| 144 | termination of RNA polymerase II transcription (GO:0006369) | 2.90529279 |
| 145 | nuclear pore complex assembly (GO:0051292) | 2.90045298 |
| 146 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.88335864 |
| 147 | ATP-dependent chromatin remodeling (GO:0043044) | 2.87217865 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.53298268 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.34313872 |
| 3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.19374053 |
| 4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.04644190 |
| 5 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.39192599 |
| 6 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.29079181 |
| 7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.26723008 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.10227166 |
| 9 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.94498119 |
| 10 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.89487561 |
| 11 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.88362950 |
| 12 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.84043445 |
| 13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.83411169 |
| 14 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.69941679 |
| 15 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.61754721 |
| 16 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.43440850 |
| 17 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.39135175 |
| 18 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.37642230 |
| 19 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.35440135 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.33145427 |
| 21 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.31230720 |
| 22 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.29828833 |
| 23 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.21399153 |
| 24 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.20737823 |
| 25 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.17065481 |
| 26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.15104764 |
| 27 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.08152050 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.96796433 |
| 29 | * MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.96715084 |
| 30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.95607565 |
| 31 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.95076455 |
| 32 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.93366810 |
| 33 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.93309359 |
| 34 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.93060613 |
| 35 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.90385949 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.87786767 |
| 37 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.85584966 |
| 38 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.80682470 |
| 39 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.79261377 |
| 40 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.79251639 |
| 41 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.77044941 |
| 42 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.76956487 |
| 43 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.76088105 |
| 44 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.75838886 |
| 45 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.75113622 |
| 46 | * YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.74483253 |
| 47 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.74338473 |
| 48 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.73807689 |
| 49 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.69823820 |
| 50 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.69822008 |
| 51 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.69385665 |
| 52 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66872692 |
| 53 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.53708714 |
| 54 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.47203870 |
| 55 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.47138366 |
| 56 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.45780098 |
| 57 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.45717517 |
| 58 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.41832152 |
| 59 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.40788465 |
| 60 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.37299071 |
| 61 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.36940285 |
| 62 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.36869275 |
| 63 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.35837966 |
| 64 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.35825135 |
| 65 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.35557485 |
| 66 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.31033348 |
| 67 | MYC_22102868_ChIP-Seq_BL_Human | 1.30877050 |
| 68 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.30311363 |
| 69 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.23377064 |
| 70 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.21675610 |
| 71 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.19948348 |
| 72 | EWS_26573619_Chip-Seq_HEK293_Human | 1.19215486 |
| 73 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.15644126 |
| 74 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.14582776 |
| 75 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.13500681 |
| 76 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.10960125 |
| 77 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.10204465 |
| 78 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.09938068 |
| 79 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.09739930 |
| 80 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.04304558 |
| 81 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.03185383 |
| 82 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.01268166 |
| 83 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.01076401 |
| 84 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.00069669 |
| 85 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.99570703 |
| 86 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.98482051 |
| 87 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.97388673 |
| 88 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.97086723 |
| 89 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.92581880 |
| 90 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.91732499 |
| 91 | FUS_26573619_Chip-Seq_HEK293_Human | 0.91504711 |
| 92 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.89855109 |
| 93 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.87009070 |
| 94 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.86733677 |
| 95 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.85635213 |
| 96 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.80586706 |
| 97 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.80369512 |
| 98 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.79971626 |
| 99 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.76694745 |
| 100 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.76264101 |
| 101 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.75931256 |
| 102 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.75793167 |
| 103 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.75184714 |
| 104 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.73393851 |
| 105 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.71825462 |
| 106 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.70274741 |
| 107 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.70242450 |
| 108 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.68202518 |
| 109 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.68199462 |
| 110 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.67941179 |
| 111 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.67779335 |
| 112 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.67055911 |
| 113 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.63601484 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010094_abnormal_chromosome_stability | 4.63206636 |
| 2 | MP0003693_abnormal_embryo_hatching | 4.56827934 |
| 3 | MP0003111_abnormal_nucleus_morphology | 4.22173592 |
| 4 | MP0008057_abnormal_DNA_replication | 4.04655984 |
| 5 | MP0008058_abnormal_DNA_repair | 3.93570671 |
| 6 | MP0003077_abnormal_cell_cycle | 3.77475132 |
| 7 | MP0004957_abnormal_blastocyst_morpholog | 3.69717711 |
| 8 | MP0008007_abnormal_cellular_replicative | 3.34606664 |
| 9 | MP0002396_abnormal_hematopoietic_system | 2.67974654 |
| 10 | MP0006292_abnormal_olfactory_placode | 2.63491970 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.50358589 |
| 12 | MP0003123_paternal_imprinting | 2.29469505 |
| 13 | MP0003786_premature_aging | 1.99081735 |
| 14 | MP0003806_abnormal_nucleotide_metabolis | 1.95075665 |
| 15 | MP0006035_abnormal_mitochondrial_morpho | 1.90467431 |
| 16 | MP0000350_abnormal_cell_proliferation | 1.87517275 |
| 17 | MP0000490_abnormal_crypts_of | 1.85848755 |
| 18 | MP0001529_abnormal_vocalization | 1.85473452 |
| 19 | MP0010030_abnormal_orbit_morphology | 1.84351564 |
| 20 | MP0009053_abnormal_anal_canal | 1.82533847 |
| 21 | MP0008877_abnormal_DNA_methylation | 1.80455741 |
| 22 | MP0006036_abnormal_mitochondrial_physio | 1.74897842 |
| 23 | MP0001730_embryonic_growth_arrest | 1.73303462 |
| 24 | MP0003121_genomic_imprinting | 1.58706396 |
| 25 | MP0001293_anophthalmia | 1.58592972 |
| 26 | MP0006072_abnormal_retinal_apoptosis | 1.58374362 |
| 27 | MP0004808_abnormal_hematopoietic_stem | 1.56660973 |
| 28 | MP0005380_embryogenesis_phenotype | 1.51442357 |
| 29 | MP0001672_abnormal_embryogenesis/_devel | 1.51442357 |
| 30 | MP0003763_abnormal_thymus_physiology | 1.47952957 |
| 31 | MP0001697_abnormal_embryo_size | 1.46148764 |
| 32 | MP0000313_abnormal_cell_death | 1.43571636 |
| 33 | MP0000372_irregular_coat_pigmentation | 1.41840831 |
| 34 | MP0002160_abnormal_reproductive_system | 1.41819624 |
| 35 | MP0000537_abnormal_urethra_morphology | 1.39382628 |
| 36 | MP0003136_yellow_coat_color | 1.37183355 |
| 37 | MP0003984_embryonic_growth_retardation | 1.36765132 |
| 38 | MP0002085_abnormal_embryonic_tissue | 1.34429913 |
| 39 | MP0003315_abnormal_perineum_morphology | 1.33664943 |
| 40 | MP0002088_abnormal_embryonic_growth/wei | 1.32152966 |
| 41 | MP0010352_gastrointestinal_tract_polyps | 1.31908680 |
| 42 | MP0002019_abnormal_tumor_incidence | 1.31135832 |
| 43 | MP0009672_abnormal_birth_weight | 1.26671606 |
| 44 | MP0002080_prenatal_lethality | 1.25292015 |
| 45 | MP0000703_abnormal_thymus_morphology | 1.24904321 |
| 46 | MP0010307_abnormal_tumor_latency | 1.23711009 |
| 47 | MP0002398_abnormal_bone_marrow | 1.23569713 |
| 48 | MP0002210_abnormal_sex_determination | 1.22704278 |
| 49 | MP0003567_abnormal_fetal_cardiomyocyte | 1.21652092 |
| 50 | MP0008789_abnormal_olfactory_epithelium | 1.20271798 |
| 51 | MP0002084_abnormal_developmental_patter | 1.13405277 |
| 52 | MP0003890_abnormal_embryonic-extraembry | 1.12296617 |
| 53 | MP0001188_hyperpigmentation | 1.09928197 |
| 54 | MP0004197_abnormal_fetal_growth/weight/ | 1.09391876 |
| 55 | MP0002233_abnormal_nose_morphology | 1.08111693 |
| 56 | MP0001145_abnormal_male_reproductive | 1.07175555 |
| 57 | MP0002722_abnormal_immune_system | 1.07035906 |
| 58 | MP0002086_abnormal_extraembryonic_tissu | 1.06872284 |
| 59 | MP0009697_abnormal_copulation | 1.06280871 |
| 60 | MP0000049_abnormal_middle_ear | 1.03800510 |
| 61 | MP0008995_early_reproductive_senescence | 1.03697420 |
| 62 | MP0000689_abnormal_spleen_morphology | 1.02832936 |
| 63 | MP0002132_abnormal_respiratory_system | 1.02224029 |
| 64 | MP0002095_abnormal_skin_pigmentation | 1.02032702 |
| 65 | MP0002938_white_spotting | 1.00443536 |
| 66 | MP0003941_abnormal_skin_development | 1.00368654 |
| 67 | MP0005389_reproductive_system_phenotype | 1.00053212 |
| 68 | MP0000647_abnormal_sebaceous_gland | 1.00009363 |
| 69 | MP0005397_hematopoietic_system_phenotyp | 0.99688320 |
| 70 | MP0001545_abnormal_hematopoietic_system | 0.99688320 |
| 71 | MP0005671_abnormal_response_to | 0.98005017 |
| 72 | MP0009333_abnormal_splenocyte_physiolog | 0.95762226 |
| 73 | MP0003119_abnormal_digestive_system | 0.95589297 |
| 74 | MP0001286_abnormal_eye_development | 0.95167442 |
| 75 | MP0001764_abnormal_homeostasis | 0.94077860 |
| 76 | MP0001929_abnormal_gametogenesis | 0.93721998 |
| 77 | MP0002234_abnormal_pharynx_morphology | 0.93486479 |
| 78 | MP0005253_abnormal_eye_physiology | 0.92400918 |
| 79 | MP0005075_abnormal_melanosome_morpholog | 0.92132924 |
| 80 | MP0002429_abnormal_blood_cell | 0.91635789 |
| 81 | MP0002102_abnormal_ear_morphology | 0.91562356 |
| 82 | MP0003787_abnormal_imprinting | 0.91239255 |
| 83 | MP0002090_abnormal_vision | 0.90715071 |
| 84 | MP0001119_abnormal_female_reproductive | 0.89967750 |
| 85 | MP0000653_abnormal_sex_gland | 0.89837124 |
| 86 | MP0003718_maternal_effect | 0.89677833 |
| 87 | MP0004133_heterotaxia | 0.89253367 |
| 88 | MP0001835_abnormal_antigen_presentation | 0.88573720 |
| 89 | MP0003221_abnormal_cardiomyocyte_apopto | 0.88010205 |
| 90 | MP0002697_abnormal_eye_size | 0.86572328 |
| 91 | MP0003943_abnormal_hepatobiliary_system | 0.86463987 |
| 92 | MP0000566_synostosis | 0.86459696 |
| 93 | MP0002111_abnormal_tail_morphology | 0.84268769 |
| 94 | MP0000858_altered_metastatic_potential | 0.84215368 |
| 95 | MP0002751_abnormal_autonomic_nervous | 0.84073657 |
| 96 | MP0005408_hypopigmentation | 0.83678855 |
| 97 | MP0000716_abnormal_immune_system | 0.83598690 |
| 98 | MP0005174_abnormal_tail_pigmentation | 0.82689078 |
| 99 | MP0005367_renal/urinary_system_phenotyp | 0.81592507 |
| 100 | MP0000516_abnormal_urinary_system | 0.81592507 |
| 101 | MP0003186_abnormal_redox_activity | 0.81278451 |
| 102 | MP0003937_abnormal_limbs/digits/tail_de | 0.79598741 |
| 103 | MP0005084_abnormal_gallbladder_morpholo | 0.78516215 |
| 104 | MP0005395_other_phenotype | 0.76509998 |
| 105 | MP0000015_abnormal_ear_pigmentation | 0.76253007 |
| 106 | MP0005394_taste/olfaction_phenotype | 0.74279733 |
| 107 | MP0005499_abnormal_olfactory_system | 0.74279733 |
| 108 | MP0001800_abnormal_humoral_immune | 0.74262676 |
| 109 | MP0005391_vision/eye_phenotype | 0.74175606 |
| 110 | MP0002420_abnormal_adaptive_immunity | 0.73954918 |
| 111 | MP0009703_decreased_birth_body | 0.73894964 |
| 112 | MP0001819_abnormal_immune_cell | 0.72830864 |
| 113 | MP0003698_abnormal_male_reproductive | 0.72517055 |
| 114 | MP0000358_abnormal_cell_content/ | 0.71999446 |
| 115 | MP0001919_abnormal_reproductive_system | 0.71362446 |
| 116 | MP0001324_abnormal_eye_pigmentation | 0.69063373 |
| 117 | MP0002452_abnormal_antigen_presenting | 0.67406621 |
| 118 | MP0002092_abnormal_eye_morphology | 0.64582023 |
| 119 | MP0001853_heart_inflammation | 0.64438925 |
| 120 | MP0002114_abnormal_axial_skeleton | 0.64156260 |
| 121 | MP0004147_increased_porphyrin_level | 0.62869090 |
| 122 | MP0002736_abnormal_nociception_after | 0.62681422 |
| 123 | MP0002075_abnormal_coat/hair_pigmentati | 0.62357350 |
| 124 | MP0001727_abnormal_embryo_implantation | 0.62132909 |
| 125 | MP0005384_cellular_phenotype | 0.61822992 |
| 126 | MP0003942_abnormal_urinary_system | 0.60263904 |
| 127 | MP0003861_abnormal_nervous_system | 0.58314694 |
| 128 | MP0002161_abnormal_fertility/fecundity | 0.57282947 |
| 129 | MP0003755_abnormal_palate_morphology | 0.49931717 |
| 130 | MP0009379_abnormal_foot_pigmentation | 0.49704347 |
| 131 | MP0002163_abnormal_gland_morphology | 0.46134144 |
| 132 | MP0005187_abnormal_penis_morphology | 0.45917924 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.53876829 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 3.92909938 |
| 3 | Breast hypoplasia (HP:0003187) | 3.88229165 |
| 4 | Reticulocytopenia (HP:0001896) | 3.85580039 |
| 5 | Chromsome breakage (HP:0040012) | 3.85298120 |
| 6 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.75950511 |
| 7 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.68326531 |
| 8 | Aplastic anemia (HP:0001915) | 3.59395632 |
| 9 | Acute encephalopathy (HP:0006846) | 3.57701135 |
| 10 | Mitochondrial inheritance (HP:0001427) | 3.35374279 |
| 11 | Increased CSF lactate (HP:0002490) | 3.31841079 |
| 12 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.23876023 |
| 13 | Patellar aplasia (HP:0006443) | 3.19379609 |
| 14 | Increased hepatocellular lipid droplets (HP:0006565) | 3.18633918 |
| 15 | Increased serum pyruvate (HP:0003542) | 3.17367357 |
| 16 | Abnormal number of erythroid precursors (HP:0012131) | 3.15131556 |
| 17 | Hepatocellular necrosis (HP:0001404) | 3.14805959 |
| 18 | Progressive macrocephaly (HP:0004481) | 3.14803485 |
| 19 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.14158547 |
| 20 | Abnormal number of incisors (HP:0011064) | 3.08613170 |
| 21 | Abnormality of the preputium (HP:0100587) | 3.07003618 |
| 22 | Selective tooth agenesis (HP:0001592) | 3.04292554 |
| 23 | Colon cancer (HP:0003003) | 3.02616173 |
| 24 | Abnormality of glycolysis (HP:0004366) | 3.02194862 |
| 25 | Meckel diverticulum (HP:0002245) | 3.02043716 |
| 26 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.01463984 |
| 27 | Cerebral edema (HP:0002181) | 2.95602092 |
| 28 | Lipid accumulation in hepatocytes (HP:0006561) | 2.93965392 |
| 29 | Abnormality of the ileum (HP:0001549) | 2.90313043 |
| 30 | Hepatic necrosis (HP:0002605) | 2.89446903 |
| 31 | Microvesicular hepatic steatosis (HP:0001414) | 2.84731302 |
| 32 | Abnormality of chromosome stability (HP:0003220) | 2.83770110 |
| 33 | Abnormal lung lobation (HP:0002101) | 2.77123973 |
| 34 | Myelodysplasia (HP:0002863) | 2.75967259 |
| 35 | Increased serum lactate (HP:0002151) | 2.69746124 |
| 36 | Oral leukoplakia (HP:0002745) | 2.68469231 |
| 37 | Absent thumb (HP:0009777) | 2.65336723 |
| 38 | Bone marrow hypocellularity (HP:0005528) | 2.63281942 |
| 39 | Abnormal glycosylation (HP:0012345) | 2.60218002 |
| 40 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.60218002 |
| 41 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.60218002 |
| 42 | Abnormal protein glycosylation (HP:0012346) | 2.60218002 |
| 43 | Pallor (HP:0000980) | 2.52983152 |
| 44 | Abnormality of the anterior horn cell (HP:0006802) | 2.52973492 |
| 45 | Degeneration of anterior horn cells (HP:0002398) | 2.52973492 |
| 46 | Supernumerary spleens (HP:0009799) | 2.50849315 |
| 47 | Premature graying of hair (HP:0002216) | 2.45380459 |
| 48 | Hyperglycinemia (HP:0002154) | 2.45179859 |
| 49 | Small intestinal stenosis (HP:0012848) | 2.44997436 |
| 50 | Duodenal stenosis (HP:0100867) | 2.44997436 |
| 51 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.43479542 |
| 52 | Medulloblastoma (HP:0002885) | 2.41568453 |
| 53 | Lactic acidosis (HP:0003128) | 2.41483016 |
| 54 | Abnormality of methionine metabolism (HP:0010901) | 2.41008608 |
| 55 | Abnormality of the labia minora (HP:0012880) | 2.40173428 |
| 56 | Macrocytic anemia (HP:0001972) | 2.38444255 |
| 57 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.35727144 |
| 58 | Multiple enchondromatosis (HP:0005701) | 2.35669590 |
| 59 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.31729578 |
| 60 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.31729578 |
| 61 | Reduced antithrombin III activity (HP:0001976) | 2.28238519 |
| 62 | Ectopic kidney (HP:0000086) | 2.27059228 |
| 63 | Short middle phalanx of the 5th finger (HP:0004220) | 2.26213431 |
| 64 | Cortical dysplasia (HP:0002539) | 2.25196072 |
| 65 | Rough bone trabeculation (HP:0100670) | 2.24559078 |
| 66 | Abnormality of serum amino acid levels (HP:0003112) | 2.22887636 |
| 67 | Exercise intolerance (HP:0003546) | 2.20468785 |
| 68 | Impulsivity (HP:0100710) | 2.19395741 |
| 69 | Agnosia (HP:0010524) | 2.19372833 |
| 70 | Sloping forehead (HP:0000340) | 2.19133609 |
| 71 | Increased intramyocellular lipid droplets (HP:0012240) | 2.17607287 |
| 72 | Optic nerve coloboma (HP:0000588) | 2.16963678 |
| 73 | Embryonal renal neoplasm (HP:0011794) | 2.16654416 |
| 74 | Triphalangeal thumb (HP:0001199) | 2.15430532 |
| 75 | IgM deficiency (HP:0002850) | 2.13684991 |
| 76 | Abnormality of the carotid arteries (HP:0005344) | 2.12782226 |
| 77 | Methylmalonic acidemia (HP:0002912) | 2.12169863 |
| 78 | Cellular immunodeficiency (HP:0005374) | 2.11030792 |
| 79 | Increased nuchal translucency (HP:0010880) | 2.10371145 |
| 80 | Renal Fanconi syndrome (HP:0001994) | 2.10333739 |
| 81 | Carpal bone hypoplasia (HP:0001498) | 2.09539617 |
| 82 | Tracheoesophageal fistula (HP:0002575) | 2.08975087 |
| 83 | Absent radius (HP:0003974) | 2.07736246 |
| 84 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.06993760 |
| 85 | Horseshoe kidney (HP:0000085) | 2.06843514 |
| 86 | Leukodystrophy (HP:0002415) | 2.06090360 |
| 87 | Duplicated collecting system (HP:0000081) | 2.06042826 |
| 88 | Clubbing of toes (HP:0100760) | 2.05776514 |
| 89 | Abnormality of the duodenum (HP:0002246) | 2.05589010 |
| 90 | Pancytopenia (HP:0001876) | 2.05290484 |
| 91 | 11 pairs of ribs (HP:0000878) | 2.04478789 |
| 92 | Atresia of the external auditory canal (HP:0000413) | 2.03912495 |
| 93 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.01411251 |
| 94 | Cleft eyelid (HP:0000625) | 1.99220319 |
| 95 | Spastic diplegia (HP:0001264) | 1.99041793 |
| 96 | Ependymoma (HP:0002888) | 1.98728204 |
| 97 | 3-Methylglutaconic aciduria (HP:0003535) | 1.96617339 |
| 98 | Abnormality of glycine metabolism (HP:0010895) | 1.96531309 |
| 99 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.96531309 |
| 100 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.96486064 |
| 101 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.95414711 |
| 102 | Short 4th metacarpal (HP:0010044) | 1.95414711 |
| 103 | Rhabdomyosarcoma (HP:0002859) | 1.95388323 |
| 104 | Abnormality of the incisor (HP:0000676) | 1.95385926 |
| 105 | Abnormality of the renal collecting system (HP:0004742) | 1.95035085 |
| 106 | Microretrognathia (HP:0000308) | 1.94301304 |
| 107 | Respiratory failure (HP:0002878) | 1.92755152 |
| 108 | Aplasia involving forearm bones (HP:0009822) | 1.92269622 |
| 109 | Absent forearm bone (HP:0003953) | 1.92269622 |
| 110 | Cerebral hypomyelination (HP:0006808) | 1.92247174 |
| 111 | Neoplasm of the pancreas (HP:0002894) | 1.92064225 |
| 112 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.91354506 |
| 113 | Respiratory difficulties (HP:0002880) | 1.89696011 |
| 114 | Postnatal microcephaly (HP:0005484) | 1.89175621 |
| 115 | Methylmalonic aciduria (HP:0012120) | 1.89062379 |
| 116 | Volvulus (HP:0002580) | 1.88559029 |
| 117 | Abnormality of alanine metabolism (HP:0010916) | 1.86787622 |
| 118 | Hyperalaninemia (HP:0003348) | 1.86787622 |
| 119 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.86787622 |
| 120 | Neoplasm of the colon (HP:0100273) | 1.86170688 |
| 121 | Lethargy (HP:0001254) | 1.85659888 |
| 122 | Abnormality of the columella (HP:0009929) | 1.84228855 |
| 123 | Pancreatic cysts (HP:0001737) | 1.84137396 |
| 124 | Hypoplasia of the pons (HP:0012110) | 1.83659153 |
| 125 | Abnormality of DNA repair (HP:0003254) | 1.83349262 |
| 126 | Abnormality of the pons (HP:0007361) | 1.82900711 |
| 127 | Type I transferrin isoform profile (HP:0003642) | 1.82412768 |
| 128 | Asplenia (HP:0001746) | 1.81219226 |
| 129 | Lymphoma (HP:0002665) | 1.79378444 |
| 130 | Deviation of the thumb (HP:0009603) | 1.78295155 |
| 131 | Megaloblastic anemia (HP:0001889) | 1.78074601 |
| 132 | Squamous cell carcinoma (HP:0002860) | 1.77698399 |
| 133 | Proximal placement of thumb (HP:0009623) | 1.77564151 |
| 134 | Thrombocytosis (HP:0001894) | 1.75700016 |
| 135 | Facial cleft (HP:0002006) | 1.75696446 |
| 136 | Neoplasm of the oral cavity (HP:0100649) | 1.75329341 |
| 137 | Optic disc pallor (HP:0000543) | 1.75091092 |
| 138 | Slender long bone (HP:0003100) | 1.74758131 |
| 139 | Hyperglycinuria (HP:0003108) | 1.72836333 |
| 140 | Facial hemangioma (HP:0000329) | 1.71662491 |
| 141 | Short thumb (HP:0009778) | 1.69975130 |
| 142 | Hypoplastic labia majora (HP:0000059) | 1.69761101 |
| 143 | Renal duplication (HP:0000075) | 1.69187601 |
| 144 | IgG deficiency (HP:0004315) | 1.65296661 |
| 145 | Bifid tongue (HP:0010297) | 1.65174066 |
| 146 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.65150045 |
| 147 | Muscle fiber atrophy (HP:0100295) | 1.64655454 |
| 148 | Long eyelashes (HP:0000527) | 1.62882828 |
| 149 | Mesomelia (HP:0003027) | 1.62441920 |
| 150 | Abnormal hair whorl (HP:0010721) | 1.61696102 |
| 151 | Secondary amenorrhea (HP:0000869) | 1.59977660 |
| 152 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.59893120 |
| 153 | Intestinal atresia (HP:0011100) | 1.59886195 |
| 154 | Hypoplasia of the radius (HP:0002984) | 1.58397078 |
| 155 | Pendular nystagmus (HP:0012043) | 1.58248455 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 4.04328378 |
| 2 | WEE1 | 3.95233997 |
| 3 | BUB1 | 3.94884379 |
| 4 | VRK2 | 3.67569163 |
| 5 | TLK1 | 3.19451861 |
| 6 | STK16 | 2.94948654 |
| 7 | SRPK1 | 2.87330164 |
| 8 | PLK4 | 2.84529916 |
| 9 | EIF2AK1 | 2.84080010 |
| 10 | NEK2 | 2.64889071 |
| 11 | MKNK1 | 2.36107145 |
| 12 | TRIM28 | 2.33481893 |
| 13 | NME2 | 2.33339387 |
| 14 | VRK1 | 2.18720188 |
| 15 | MKNK2 | 2.10708777 |
| 16 | ACVR1B | 2.07453826 |
| 17 | MST4 | 2.03172807 |
| 18 | NUAK1 | 1.98186734 |
| 19 | PLK1 | 1.94348044 |
| 20 | TESK2 | 1.86286765 |
| 21 | ATR | 1.85811612 |
| 22 | TTK | 1.84034107 |
| 23 | ZAK | 1.83012556 |
| 24 | TSSK6 | 1.82518128 |
| 25 | BRSK2 | 1.80451003 |
| 26 | PASK | 1.79145285 |
| 27 | CDK7 | 1.76922475 |
| 28 | WNK3 | 1.67242785 |
| 29 | EIF2AK3 | 1.65553194 |
| 30 | BCKDK | 1.64253099 |
| 31 | CCNB1 | 1.63988722 |
| 32 | PLK3 | 1.62111342 |
| 33 | TAF1 | 1.57588340 |
| 34 | AURKB | 1.54077721 |
| 35 | BRD4 | 1.51171638 |
| 36 | TNIK | 1.50283825 |
| 37 | RPS6KA4 | 1.43465776 |
| 38 | TAOK2 | 1.37622470 |
| 39 | DYRK3 | 1.37566771 |
| 40 | NME1 | 1.37246557 |
| 41 | MAP4K2 | 1.33040549 |
| 42 | CHEK2 | 1.26829185 |
| 43 | EIF2AK2 | 1.23604762 |
| 44 | BCR | 1.18050327 |
| 45 | BRSK1 | 1.15002420 |
| 46 | TGFBR1 | 1.12641776 |
| 47 | MAP4K1 | 1.07466878 |
| 48 | CDK8 | 1.06573070 |
| 49 | RPS6KB2 | 1.05768287 |
| 50 | CHEK1 | 1.03962550 |
| 51 | AURKA | 1.03909625 |
| 52 | CSNK1G3 | 0.98147510 |
| 53 | PIM2 | 0.95895404 |
| 54 | CSNK1G1 | 0.95741022 |
| 55 | PDK2 | 0.95092176 |
| 56 | NEK1 | 0.93812552 |
| 57 | TXK | 0.92648571 |
| 58 | ATM | 0.91657824 |
| 59 | CLK1 | 0.91399244 |
| 60 | FLT3 | 0.89360245 |
| 61 | BTK | 0.88013991 |
| 62 | YES1 | 0.87844193 |
| 63 | PIM1 | 0.86716035 |
| 64 | ERBB3 | 0.85584137 |
| 65 | STK4 | 0.84561149 |
| 66 | CDK4 | 0.84498972 |
| 67 | IRAK4 | 0.81625048 |
| 68 | MAP3K8 | 0.80977388 |
| 69 | PAK4 | 0.80392749 |
| 70 | CDK12 | 0.79266828 |
| 71 | CSNK1A1L | 0.77143865 |
| 72 | CDK2 | 0.76058992 |
| 73 | CSNK1G2 | 0.72973641 |
| 74 | PLK2 | 0.72037932 |
| 75 | MAP3K11 | 0.71424252 |
| 76 | TEC | 0.70836433 |
| 77 | KDR | 0.68756684 |
| 78 | BRAF | 0.67245704 |
| 79 | CSNK2A1 | 0.67132228 |
| 80 | RPS6KC1 | 0.63918946 |
| 81 | RPS6KL1 | 0.63918946 |
| 82 | RPS6KA5 | 0.62501706 |
| 83 | SIK3 | 0.62105437 |
| 84 | RPS6KA6 | 0.61593940 |
| 85 | ERBB4 | 0.61206520 |
| 86 | MAP2K7 | 0.60891135 |
| 87 | CDK1 | 0.60393988 |
| 88 | KIT | 0.60187585 |
| 89 | CSNK2A2 | 0.59635207 |
| 90 | BMPR1B | 0.59618961 |
| 91 | ALK | 0.59134683 |
| 92 | MAP3K4 | 0.58369829 |
| 93 | MAP3K12 | 0.55915559 |
| 94 | DYRK2 | 0.55783818 |
| 95 | AKT3 | 0.52946702 |
| 96 | EPHA2 | 0.51873878 |
| 97 | PBK | 0.48950429 |
| 98 | EPHB2 | 0.47972099 |
| 99 | STK10 | 0.47813620 |
| 100 | PNCK | 0.47803468 |
| 101 | ICK | 0.47689811 |
| 102 | SCYL2 | 0.46708546 |
| 103 | CDK19 | 0.44102558 |
| 104 | LYN | 0.43986834 |
| 105 | DAPK1 | 0.42994267 |
| 106 | CDK9 | 0.41782473 |
| 107 | TAOK3 | 0.41770188 |
| 108 | MELK | 0.41279952 |
| 109 | CHUK | 0.40948008 |
| 110 | MAP2K3 | 0.40477813 |
| 111 | STK3 | 0.40403032 |
| 112 | RPS6KB1 | 0.40401739 |
| 113 | PRKCI | 0.37707647 |
| 114 | PAK1 | 0.37278218 |
| 115 | CSNK1E | 0.36596355 |
| 116 | IRAK3 | 0.36380662 |
| 117 | CSF1R | 0.36062312 |
| 118 | IKBKB | 0.36007869 |
| 119 | STK38L | 0.34618166 |
| 120 | CDK3 | 0.34167740 |
| 121 | LIMK1 | 0.33657715 |
| 122 | GRK1 | 0.33536478 |
| 123 | BLK | 0.33160399 |
| 124 | CDK14 | 0.31729867 |
| 125 | AKT2 | 0.31359339 |
| 126 | FGFR1 | 0.30300144 |
| 127 | CDK18 | 0.29909678 |
| 128 | ILK | 0.29640306 |
| 129 | TESK1 | 0.26879285 |
| 130 | AKT1 | 0.26274278 |
| 131 | MAPKAPK5 | 0.25937787 |
| 132 | CDK11A | 0.25592019 |
| 133 | SYK | 0.24924024 |
| 134 | PRKDC | 0.23816046 |
| 135 | ZAP70 | 0.23012440 |
| 136 | MAP3K5 | 0.22992273 |
| 137 | RPS6KA1 | 0.21503478 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.16632635 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.33129764 |
| 3 | Base excision repair_Homo sapiens_hsa03410 | 3.41792807 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.39434708 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.31576127 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.30113838 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 3.28181879 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 3.27550518 |
| 9 | Proteasome_Homo sapiens_hsa03050 | 3.15920163 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.85788037 |
| 11 | RNA transport_Homo sapiens_hsa03013 | 2.80558205 |
| 12 | Cell cycle_Homo sapiens_hsa04110 | 2.67153911 |
| 13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.59685286 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.58552981 |
| 15 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.41485133 |
| 16 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.39130986 |
| 17 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.21301052 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.93392261 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.88457192 |
| 20 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.73958919 |
| 21 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.54397737 |
| 22 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.49800964 |
| 23 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.49708671 |
| 24 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.48768758 |
| 25 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.47169232 |
| 26 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.45443989 |
| 27 | Purine metabolism_Homo sapiens_hsa00230 | 1.42967955 |
| 28 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.41290346 |
| 29 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.36810147 |
| 30 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.33778362 |
| 31 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.30784987 |
| 32 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.30602044 |
| 33 | Alzheimers disease_Homo sapiens_hsa05010 | 1.29996067 |
| 34 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.23849688 |
| 35 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.20736837 |
| 36 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.20578708 |
| 37 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.15424033 |
| 38 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.15163082 |
| 39 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.11621572 |
| 40 | Carbon metabolism_Homo sapiens_hsa01200 | 1.08615379 |
| 41 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.01439356 |
| 42 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.97578014 |
| 43 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.97554049 |
| 44 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.90768661 |
| 45 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.85633736 |
| 46 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.81927373 |
| 47 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.79564442 |
| 48 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.74607625 |
| 49 | HTLV-I infection_Homo sapiens_hsa05166 | 0.73772642 |
| 50 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.70873351 |
| 51 | Protein export_Homo sapiens_hsa03060 | 0.70831317 |
| 52 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.68518088 |
| 53 | Measles_Homo sapiens_hsa05162 | 0.65335504 |
| 54 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.63571676 |
| 55 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.63170825 |
| 56 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.61309746 |
| 57 | Legionellosis_Homo sapiens_hsa05134 | 0.61077520 |
| 58 | Huntingtons disease_Homo sapiens_hsa05016 | 0.60649747 |
| 59 | Allograft rejection_Homo sapiens_hsa05330 | 0.60083195 |
| 60 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.59530988 |
| 61 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.58614175 |
| 62 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.57172680 |
| 63 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.53934278 |
| 64 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.51941123 |
| 65 | Alcoholism_Homo sapiens_hsa05034 | 0.51591038 |
| 66 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.51389014 |
| 67 | Peroxisome_Homo sapiens_hsa04146 | 0.51344270 |
| 68 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.50848659 |
| 69 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.49675724 |
| 70 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.49154837 |
| 71 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.47104519 |
| 72 | Colorectal cancer_Homo sapiens_hsa05210 | 0.46887209 |
| 73 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.46680315 |
| 74 | Apoptosis_Homo sapiens_hsa04210 | 0.46150936 |
| 75 | Hepatitis B_Homo sapiens_hsa05161 | 0.46149308 |
| 76 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.44964429 |
| 77 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.44283484 |
| 78 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.44008046 |
| 79 | Thyroid cancer_Homo sapiens_hsa05216 | 0.43612901 |
| 80 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.43289230 |
| 81 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.43177881 |
| 82 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.42792482 |
| 83 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.42181871 |
| 84 | Influenza A_Homo sapiens_hsa05164 | 0.41764979 |
| 85 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.40635823 |
| 86 | Asthma_Homo sapiens_hsa05310 | 0.36442382 |
| 87 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.35571467 |
| 88 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.33541883 |
| 89 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.33496368 |
| 90 | Parkinsons disease_Homo sapiens_hsa05012 | 0.33455175 |
| 91 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.32069609 |
| 92 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.30869462 |
| 93 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.30550186 |
| 94 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.30397276 |
| 95 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.30024637 |
| 96 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.29812811 |
| 97 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.28993230 |
| 98 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.28566555 |
| 99 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.27595791 |
| 100 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.27574558 |
| 101 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.27474001 |
| 102 | Viral myocarditis_Homo sapiens_hsa05416 | 0.25830020 |
| 103 | Leishmaniasis_Homo sapiens_hsa05140 | 0.25445406 |
| 104 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.25177694 |
| 105 | Pathways in cancer_Homo sapiens_hsa05200 | 0.24915160 |
| 106 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.24843158 |
| 107 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.24709170 |
| 108 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.24346909 |
| 109 | Shigellosis_Homo sapiens_hsa05131 | 0.23733997 |
| 110 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.22955591 |
| 111 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.22740574 |
| 112 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.22576428 |
| 113 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.22289841 |
| 114 | Sulfur relay system_Homo sapiens_hsa04122 | 0.21323992 |
| 115 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.20496272 |
| 116 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.19936384 |
| 117 | Lysine degradation_Homo sapiens_hsa00310 | 0.18858901 |
| 118 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.18394359 |
| 119 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.18211623 |
| 120 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.17887312 |
| 121 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.16245986 |
| 122 | Prostate cancer_Homo sapiens_hsa05215 | 0.16223819 |
| 123 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.15034200 |
| 124 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.14941156 |
| 125 | Phototransduction_Homo sapiens_hsa04744 | 0.14281825 |
| 126 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.14252575 |
| 127 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.13829454 |
| 128 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.13239079 |
| 129 | Metabolic pathways_Homo sapiens_hsa01100 | 0.12905214 |
| 130 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.10912685 |
| 131 | Melanoma_Homo sapiens_hsa05218 | 0.10886868 |
| 132 | Galactose metabolism_Homo sapiens_hsa00052 | 0.10617943 |
| 133 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.10460248 |
| 134 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.10060097 |
| 135 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.08649194 |
| 136 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.06807298 |
| 137 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.04447266 |
| 138 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.02428741 |
| 139 | Retinol metabolism_Homo sapiens_hsa00830 | 0.01936542 |

