SACM1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that is localized to the endoplasmic reticulum and golgi, and functions as a phosphoinositide lipid phosphatase. Studies in mammals suggest that this gene is involved in the organization of golgi membranes and the mitotic spindles. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.70231968
2nuclear pore complex assembly (GO:0051292)4.86465070
3nuclear pore organization (GO:0006999)4.82208674
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.77989377
5L-phenylalanine catabolic process (GO:0006559)4.77989377
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.45913951
7L-phenylalanine metabolic process (GO:0006558)4.45913951
8regulation of gamma-delta T cell differentiation (GO:0045586)4.43536309
9regulation of B cell receptor signaling pathway (GO:0050855)4.42830487
10Golgi transport vesicle coating (GO:0048200)4.31780874
11COPI coating of Golgi vesicle (GO:0048205)4.31780874
12response to interleukin-15 (GO:0070672)4.27850425
13mitotic sister chromatid cohesion (GO:0007064)4.19705773
14antigen processing and presentation via MHC class Ib (GO:0002475)4.16904957
15lysine catabolic process (GO:0006554)4.12582160
16lysine metabolic process (GO:0006553)4.12582160
17alpha-linolenic acid metabolic process (GO:0036109)4.01977143
18megakaryocyte development (GO:0035855)3.93346176
19regulation of gamma-delta T cell activation (GO:0046643)3.93092431
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.85340516
21negative regulation of cell killing (GO:0031342)3.85340516
22positive regulation of granulocyte differentiation (GO:0030854)3.85253341
23mitotic G2 DNA damage checkpoint (GO:0007095)3.82871876
24aromatic amino acid family catabolic process (GO:0009074)3.81508767
25sulfur amino acid catabolic process (GO:0000098)3.77563199
26phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.71449292
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.70502013
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65123373
29cellular response to interleukin-15 (GO:0071350)3.64757918
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.62319508
31cysteine metabolic process (GO:0006534)3.60864382
32positive regulation of B cell differentiation (GO:0045579)3.56140727
33mitotic G2/M transition checkpoint (GO:0044818)3.53999389
34neutrophil activation involved in immune response (GO:0002283)3.53096702
35bile acid biosynthetic process (GO:0006699)3.51871236
36phospholipid scrambling (GO:0017121)3.42608982
37urea metabolic process (GO:0019627)3.42590286
38urea cycle (GO:0000050)3.42590286
39pore complex assembly (GO:0046931)3.42240273
40definitive hemopoiesis (GO:0060216)3.41273621
41glyoxylate metabolic process (GO:0046487)3.40619652
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.40060867
43complement activation, alternative pathway (GO:0006957)3.38349806
44protein carboxylation (GO:0018214)3.36445327
45peptidyl-glutamic acid carboxylation (GO:0017187)3.36445327
46regulation of fibroblast apoptotic process (GO:2000269)3.31446376
47regulation of protein activation cascade (GO:2000257)3.31061387
48regulation of B cell differentiation (GO:0045577)3.30759294
49cellular ketone body metabolic process (GO:0046950)3.29193676
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.24501426
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.24501426
52positive regulation of mitotic sister chromatid separation (GO:1901970)3.24501426
53high-density lipoprotein particle remodeling (GO:0034375)3.22804595
54regulation of complement activation (GO:0030449)3.18447807
55sister chromatid segregation (GO:0000819)3.18246449
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16296166
57succinate metabolic process (GO:0006105)3.15853387
58positive regulation of histone H3-K4 methylation (GO:0051571)3.15013124
59negative regulation of fibroblast apoptotic process (GO:2000270)3.12178864
60interferon-gamma production (GO:0032609)3.10901472
61valine metabolic process (GO:0006573)3.10724134
62tyrosine metabolic process (GO:0006570)3.10596835
63positive regulation of glycolytic process (GO:0045821)3.10341839
64nitrogen cycle metabolic process (GO:0071941)3.10131776
65negative regulation of fibrinolysis (GO:0051918)3.09876497
66dicarboxylic acid biosynthetic process (GO:0043650)3.09566509
67glutamate metabolic process (GO:0006536)3.09340610
68cellular glucuronidation (GO:0052695)3.07982120
69homocysteine metabolic process (GO:0050667)3.07643436
70kynurenine metabolic process (GO:0070189)3.07268976
71regulation of mitotic spindle checkpoint (GO:1903504)3.06929321
72regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06929321
73reverse cholesterol transport (GO:0043691)3.06899428
74regulation of histone H3-K9 methylation (GO:0051570)3.06093143
75negative T cell selection (GO:0043383)3.06052893
76bile acid metabolic process (GO:0008206)3.05596891
77oxaloacetate metabolic process (GO:0006107)3.04802555
782-oxoglutarate metabolic process (GO:0006103)3.04421376
79drug transmembrane transport (GO:0006855)3.03109615
80regulation of cholesterol homeostasis (GO:2000188)3.01881095
81acylglycerol homeostasis (GO:0055090)3.00877614
82triglyceride homeostasis (GO:0070328)3.00877614
83aspartate family amino acid catabolic process (GO:0009068)3.00476320
84glucuronate metabolic process (GO:0019585)2.97538707
85uronic acid metabolic process (GO:0006063)2.97538707
86negative thymic T cell selection (GO:0045060)2.96398494
87regulation of Golgi to plasma membrane protein transport (GO:0042996)2.95993991
88plasma lipoprotein particle clearance (GO:0034381)2.95184988
89Rap protein signal transduction (GO:0032486)2.93728708
90retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.93061024
91antigen processing and presentation of endogenous antigen (GO:0019883)2.91845140
92indole-containing compound catabolic process (GO:0042436)2.91818505
93indolalkylamine catabolic process (GO:0046218)2.91818505
94tryptophan catabolic process (GO:0006569)2.91818505
95drug catabolic process (GO:0042737)2.88865429
96tricarboxylic acid metabolic process (GO:0072350)2.88504304
97coenzyme catabolic process (GO:0009109)2.87239962
98hepatocyte apoptotic process (GO:0097284)2.86760120
99DNA topological change (GO:0006265)2.86442778
100tryptophan metabolic process (GO:0006568)2.86004723
101cellular modified amino acid catabolic process (GO:0042219)2.85959296
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85814355
103amino-acid betaine metabolic process (GO:0006577)2.85210138
104protein-lipid complex remodeling (GO:0034368)2.84960065
105macromolecular complex remodeling (GO:0034367)2.84960065
106plasma lipoprotein particle remodeling (GO:0034369)2.84960065
107ketone body metabolic process (GO:1902224)2.84804100
108regulation of cholesterol biosynthetic process (GO:0045540)2.84397293
109regulation of fibrinolysis (GO:0051917)2.83334276
110regulation of triglyceride catabolic process (GO:0010896)2.82546102
111fatty acid oxidation (GO:0019395)2.81604576
112positive regulation of fatty acid biosynthetic process (GO:0045723)2.80903122
113establishment of chromosome localization (GO:0051303)2.80750063
114fatty acid beta-oxidation (GO:0006635)2.79715060
115acetyl-CoA metabolic process (GO:0006084)2.79703146
116low-density lipoprotein particle clearance (GO:0034383)2.78793768
117intestinal cholesterol absorption (GO:0030299)2.78397117
118lipid oxidation (GO:0034440)2.78067995
119regulation of centriole replication (GO:0046599)2.77685539
120positive regulation of alpha-beta T cell proliferation (GO:0046641)2.77654685
121activated T cell proliferation (GO:0050798)2.77579433
122macroautophagy (GO:0016236)2.76678155
123cholesterol efflux (GO:0033344)2.75417085
124aromatic amino acid family metabolic process (GO:0009072)2.73790684
125cellular amino acid catabolic process (GO:0009063)2.72317304
126alpha-amino acid catabolic process (GO:1901606)2.71470791
127monoubiquitinated protein deubiquitination (GO:0035520)2.71149844
128alkaloid metabolic process (GO:0009820)2.70664677
129fatty acid catabolic process (GO:0009062)2.68625592
130mast cell activation (GO:0045576)2.67931315
131short-chain fatty acid metabolic process (GO:0046459)2.67892794
132monocarboxylic acid catabolic process (GO:0072329)2.66974535
133positive regulation of lipid catabolic process (GO:0050996)2.66502563
134regulation of regulatory T cell differentiation (GO:0045589)2.65706293
135regulation of mitotic sister chromatid separation (GO:0010965)2.65485384
136regulation of mitotic sister chromatid segregation (GO:0033047)2.65485384
137regulation of sister chromatid segregation (GO:0033045)2.65485384
138B cell receptor signaling pathway (GO:0050853)2.65083868
139negative regulation of DNA repair (GO:0045738)2.64577423
140phospholipid efflux (GO:0033700)2.62737617
141endoderm formation (GO:0001706)2.62561125
142regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.62300093
143bile acid and bile salt transport (GO:0015721)2.60642550
144T cell homeostasis (GO:0043029)2.60177305
145T cell migration (GO:0072678)2.59595636
146regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59379259
147regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.59379259
148protein localization to kinetochore (GO:0034501)2.58863997
149phospholipid homeostasis (GO:0055091)2.58635184
150maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.58265431
151synapsis (GO:0007129)2.57671464
152negative regulation of protein activation cascade (GO:2000258)2.57489317
153dicarboxylic acid catabolic process (GO:0043649)2.57343627
154negative regulation of T cell mediated immunity (GO:0002710)2.56927735
155leukocyte degranulation (GO:0043299)2.56563550
156ethanol oxidation (GO:0006069)2.55143439
157regulation of fatty acid beta-oxidation (GO:0031998)2.54898610
158lipoprotein metabolic process (GO:0042157)2.53464978
159COPII vesicle coating (GO:0048208)2.53280451
160genitalia morphogenesis (GO:0035112)2.53142093
161regulation of cholesterol metabolic process (GO:0090181)2.53016346
162protein localization to chromosome, centromeric region (GO:0071459)2.52396180
163carboxylic acid catabolic process (GO:0046395)2.52098691
164organic acid catabolic process (GO:0016054)2.52098691
165negative regulation of sterol transport (GO:0032372)2.51951384
166negative regulation of cholesterol transport (GO:0032375)2.51951384
167benzene-containing compound metabolic process (GO:0042537)2.50699574
168fatty acid homeostasis (GO:0055089)2.49832485
169antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49598606
170somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.49210553
171somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.49210553
172isotype switching (GO:0045190)2.49210553
173CENP-A containing nucleosome assembly (GO:0034080)2.49150382
174nucleotide-sugar biosynthetic process (GO:0009226)2.48778634
175necroptotic process (GO:0070266)2.47931102
176negative regulation of mitotic sister chromatid separation (GO:2000816)2.47199735
177negative regulation of sister chromatid segregation (GO:0033046)2.47199735
178negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.47199735
179negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.47199735
180negative regulation of mitotic sister chromatid segregation (GO:0033048)2.47199735
181neutrophil activation (GO:0042119)2.47143619
182positive regulation of fatty acid beta-oxidation (GO:0032000)2.46784528
183nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.46327090
184histone H3-K36 demethylation (GO:0070544)2.46148003
185natural killer cell differentiation (GO:0001779)2.45963539
186double-strand break repair via nonhomologous end joining (GO:0006303)2.45728947
187non-recombinational repair (GO:0000726)2.45728947
188protein prenylation (GO:0018342)2.45568027
189prenylation (GO:0097354)2.45568027
190RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.45374284
191embryonic process involved in female pregnancy (GO:0060136)2.44322673
192regulation of sister chromatid cohesion (GO:0007063)2.44056495
193positive regulation of SMAD protein import into nucleus (GO:0060391)2.43922156
194negative regulation of chromosome segregation (GO:0051985)2.42852838
195regulation of DNA endoreduplication (GO:0032875)2.40561891
196regulation of chromatin silencing (GO:0031935)2.40340336
197UDP-N-acetylglucosamine metabolic process (GO:0006047)2.40206045
198mitotic metaphase plate congression (GO:0007080)2.39629534
199positive regulation of chromosome segregation (GO:0051984)2.38914997
200heparin metabolic process (GO:0030202)2.37922712

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.37755850
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.96298456
3E2F7_22180533_ChIP-Seq_HELA_Human4.82605343
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.64730439
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.99038067
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.93072767
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.66671700
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14184003
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.96870309
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90073194
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85303664
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.75480005
13GATA1_22025678_ChIP-Seq_K562_Human2.71947696
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.67111526
15CLOCK_20551151_ChIP-Seq_293T_Human2.43151128
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.26751036
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.21994768
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19788782
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10518288
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.07889549
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06587868
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.05082662
23* MYB_26560356_Chip-Seq_TH2_Human2.00456821
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.96983496
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93913518
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.93360553
27RUNX_20019798_ChIP-Seq_JUKART_Human1.91869462
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.86712453
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.81492173
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.81154873
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.81154873
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.74372877
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71898058
34* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71132606
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.68700905
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.67102017
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62981875
38ELK1_19687146_ChIP-ChIP_HELA_Human1.60396853
39MYB_26560356_Chip-Seq_TH1_Human1.57901976
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57704444
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.57593600
42* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53435644
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.51186081
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.50975149
45RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.50456756
46EWS_26573619_Chip-Seq_HEK293_Human1.49440819
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48580778
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.48007821
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46165946
50SCL_19346495_ChIP-Seq_HPC-7_Human1.45118430
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43382320
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43313655
53AR_21909140_ChIP-Seq_LNCAP_Human1.41132029
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40880037
55SPI1_23547873_ChIP-Seq_NB4_Human1.40472554
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40209101
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39757914
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39757914
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39757914
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39679597
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39033742
62FUS_26573619_Chip-Seq_HEK293_Human1.38327071
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37336342
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35597459
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35516235
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31605698
67SOX2_20726797_ChIP-Seq_SW620_Human1.31553665
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31504261
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.30889061
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30563759
71GATA3_27048872_Chip-Seq_THYMUS_Human1.30454147
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.29829516
73* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29059264
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29046314
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28781593
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28621966
77GATA3_26560356_Chip-Seq_TH2_Human1.27217954
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.27036427
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.22780083
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22606565
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.22404863
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.22185660
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.21939211
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21893073
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21600427
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20996565
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.19503451
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19085652
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18117081
90BCAT_22108803_ChIP-Seq_LS180_Human1.17094931
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16815904
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15675692
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14174004
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13467770
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.09947468
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.08953547
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08760251
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08689269
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08634260
100STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08260837
101SALL4_22934838_ChIP-ChIP_CD34+_Human1.07747144
102PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06332622
103EP300_21415370_ChIP-Seq_HL-1_Mouse1.06039756
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.05839002
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.05396182
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04749347
107CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03613745
108HNF4A_19822575_ChIP-Seq_HepG2_Human1.02640683
109VDR_22108803_ChIP-Seq_LS180_Human1.02093603
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00673003
111SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00465547
112TFEB_21752829_ChIP-Seq_HELA_Human0.99731320
113* CJUN_26792858_Chip-Seq_BT549_Human0.99659330
114* TP63_23658742_ChIP-Seq_EP156T_Human0.99487825
115PU_27001747_Chip-Seq_BMDM_Mouse0.99248135
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99136196
117SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98741314
118E2F1_21310950_ChIP-Seq_MCF-7_Human0.97935053
119HTT_18923047_ChIP-ChIP_STHdh_Human0.97195166
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95228885
121* SOX2_21211035_ChIP-Seq_LN229_Gbm0.94901478
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.94627385
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.94298466
124* VDR_23849224_ChIP-Seq_CD4+_Human0.93873331
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.93147727
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93065990
127* SMAD3_21741376_ChIP-Seq_EPCs_Human0.92338596
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91741187
129TAF15_26573619_Chip-Seq_HEK293_Human0.91262734
130SMAD4_21799915_ChIP-Seq_A2780_Human0.91094579
131* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90888994
132E2F1_18555785_Chip-Seq_ESCs_Mouse0.90844970
133GBX2_23144817_ChIP-Seq_PC3_Human0.90732058
134* GATA4_25053715_ChIP-Seq_YYC3_Human0.90704038
135* FOXP3_21729870_ChIP-Seq_TREG_Human0.90685583
136GATA1_19941826_ChIP-Seq_K562_Human0.89609075
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88945034
138RXR_22108803_ChIP-Seq_LS180_Human0.88920875
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.87907251
140SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87561759
141BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87133852
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86215146
143FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85647922
144SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85349135
145MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84719370
146POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84366010
147* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83497550
148AHR_22903824_ChIP-Seq_MCF-7_Human0.83487189
149GATA2_19941826_ChIP-Seq_K562_Human0.83314933
150SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.82922272
151DROSHA_22980978_ChIP-Seq_HELA_Human0.82789548
152PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82725104
153ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81940236
154THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80641861
155CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80144446
156NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79609401
157IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79513461
158CBP_20019798_ChIP-Seq_JUKART_Human0.79513461
159TCF4_22108803_ChIP-Seq_LS180_Human0.78830070
160WT1_19549856_ChIP-ChIP_CCG9911_Human0.77445761
161AR_25329375_ChIP-Seq_VCAP_Human0.76732607
162STAT3_23295773_ChIP-Seq_U87_Human0.76664989
163TP53_18474530_ChIP-ChIP_U2OS_Human0.75972240
164FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75860367
165GATA3_24758297_ChIP-Seq_MCF-7_Human0.75611060
166FOXM1_26456572_ChIP-Seq_MCF-7_Human0.74366963
167IGF1R_20145208_ChIP-Seq_DFB_Human0.73436146
168CDX2_22108803_ChIP-Seq_LS180_Human0.72638192
169TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72193813
170SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71813432
171* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.71721833
172ARNT_22903824_ChIP-Seq_MCF-7_Human0.71599126
173P300_19829295_ChIP-Seq_ESCs_Human0.70837991
174RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70282573
175PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.70161051
176SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.69663416
177FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68717735
178TOP2B_26459242_ChIP-Seq_MCF-7_Human0.67638966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.80876861
2MP0005360_urolithiasis5.14641960
3MP0005085_abnormal_gallbladder_physiolo4.26032949
4MP0005365_abnormal_bile_salt4.16646134
5MP0008057_abnormal_DNA_replication3.83627833
6MP0008875_abnormal_xenobiotic_pharmacok3.50593928
7MP0003890_abnormal_embryonic-extraembry3.42200953
8MP0005075_abnormal_melanosome_morpholog3.08126462
9MP0003195_calcinosis3.02048889
10MP0003252_abnormal_bile_duct3.00736218
11MP0002396_abnormal_hematopoietic_system2.90891068
12MP0003763_abnormal_thymus_physiology2.84717981
13MP0010329_abnormal_lipoprotein_level2.67472219
14MP0005083_abnormal_biliary_tract2.56137596
15MP0003806_abnormal_nucleotide_metabolis2.49014981
16MP0002877_abnormal_melanocyte_morpholog2.45133007
17MP0002009_preneoplasia2.43844511
18MP0000372_irregular_coat_pigmentation2.43659993
19MP0009780_abnormal_chondrocyte_physiolo2.42082980
20MP0005464_abnormal_platelet_physiology2.34001858
21MP0005332_abnormal_amino_acid2.31947618
22MP0001666_abnormal_nutrient_absorption2.31853355
23MP0003828_pulmonary_edema2.31531473
24MP0005671_abnormal_response_to2.27132434
25MP0000015_abnormal_ear_pigmentation2.26660160
26MP0008877_abnormal_DNA_methylation2.22922237
27MP0000465_gastrointestinal_hemorrhage2.21343946
28MP0000569_abnormal_digit_pigmentation2.19153012
29MP0004043_abnormal_pH_regulation2.17321299
30MP0010094_abnormal_chromosome_stability2.16395706
31MP0004381_abnormal_hair_follicle2.12492661
32MP0002909_abnormal_adrenal_gland2.03363876
33MP0000013_abnormal_adipose_tissue2.02438215
34MP0004957_abnormal_blastocyst_morpholog1.88345816
35MP0009840_abnormal_foam_cell1.88073481
36MP0010307_abnormal_tumor_latency1.86210447
37MP0003111_abnormal_nucleus_morphology1.83199463
38MP0001835_abnormal_antigen_presentation1.81952678
39MP0002118_abnormal_lipid_homeostasis1.79850466
40MP0010234_abnormal_vibrissa_follicle1.79399954
41MP0002138_abnormal_hepatobiliary_system1.75951202
42MP0002398_abnormal_bone_marrow1.75077779
43MP0003077_abnormal_cell_cycle1.74987620
44MP0002102_abnormal_ear_morphology1.73300354
45MP0000703_abnormal_thymus_morphology1.70410347
46MP0003705_abnormal_hypodermis_morpholog1.68789362
47MP0004130_abnormal_muscle_cell1.67753746
48MP0005058_abnormal_lysosome_morphology1.65384295
49MP0002166_altered_tumor_susceptibility1.61993448
50MP0000609_abnormal_liver_physiology1.61957914
51MP0002837_dystrophic_cardiac_calcinosis1.59779650
52MP0003868_abnormal_feces_composition1.59245708
53MP0000604_amyloidosis1.59235622
54MP0001800_abnormal_humoral_immune1.54960175
55MP0003718_maternal_effect1.54488080
56MP0001819_abnormal_immune_cell1.52736958
57MP0002420_abnormal_adaptive_immunity1.52382841
58MP0000689_abnormal_spleen_morphology1.50215954
59MP0001851_eye_inflammation1.50173495
60MP0009643_abnormal_urine_homeostasis1.50130317
61MP0005000_abnormal_immune_tolerance1.49704663
62MP0003693_abnormal_embryo_hatching1.48468594
63MP0003300_gastrointestinal_ulcer1.44939603
64MP0003191_abnormal_cellular_cholesterol1.43883335
65MP0008004_abnormal_stomach_pH1.43619667
66MP0002722_abnormal_immune_system1.43079230
67MP0001730_embryonic_growth_arrest1.40540570
68MP0005584_abnormal_enzyme/coenzyme_acti1.40293066
69MP0002723_abnormal_immune_serum1.39719915
70MP0002078_abnormal_glucose_homeostasis1.39225080
71MP0005319_abnormal_enzyme/_coenzyme1.37644536
72MP0003436_decreased_susceptibility_to1.36455552
73MP0004019_abnormal_vitamin_homeostasis1.35406049
74MP0005535_abnormal_body_temperature1.33465858
75MP0003329_amyloid_beta_deposits1.32926913
76MP0003183_abnormal_peptide_metabolism1.32357109
77MP0009697_abnormal_copulation1.32348234
78MP0002452_abnormal_antigen_presenting1.29328239
79MP0000716_abnormal_immune_system1.24571546
80MP0004808_abnormal_hematopoietic_stem1.23201456
81MP0002419_abnormal_innate_immunity1.22294868
82MP0008260_abnormal_autophagy1.21639663
83MP0005174_abnormal_tail_pigmentation1.21167914
84MP0002876_abnormal_thyroid_physiology1.20825157
85MP0001756_abnormal_urination1.17084785
86MP0002006_tumorigenesis1.15518756
87MP0001944_abnormal_pancreas_morphology1.14890162
88MP0001672_abnormal_embryogenesis/_devel1.13458137
89MP0005380_embryogenesis_phenotype1.13458137
90MP0002429_abnormal_blood_cell1.12849377
91MP0008438_abnormal_cutaneous_collagen1.11262755
92MP0010352_gastrointestinal_tract_polyps1.09514901
93MP0005220_abnormal_exocrine_pancreas1.09056080
94MP0000350_abnormal_cell_proliferation1.08361174
95MP0005084_abnormal_gallbladder_morpholo1.07183885
96MP0002405_respiratory_system_inflammati1.06481837
97MP0002693_abnormal_pancreas_physiology1.05286078
98MP0003656_abnormal_erythrocyte_physiolo1.04401718
99MP0001765_abnormal_ion_homeostasis1.02511998
100MP0003172_abnormal_lysosome_physiology1.02157209
101MP0008058_abnormal_DNA_repair1.01982081
102MP0001790_abnormal_immune_system1.01538211
103MP0005387_immune_system_phenotype1.01538211
104MP0000371_diluted_coat_color0.99248154
105MP0010386_abnormal_urinary_bladder0.97733470
106MP0003690_abnormal_glial_cell0.97553217
107MP0005636_abnormal_mineral_homeostasis0.97081434
108MP0003950_abnormal_plasma_membrane0.96740544
109MP0009333_abnormal_splenocyte_physiolog0.95889661
110MP0005025_abnormal_response_to0.95736629
111MP0003984_embryonic_growth_retardation0.95613185
112MP0002088_abnormal_embryonic_growth/wei0.94539752
113MP0005310_abnormal_salivary_gland0.94453571
114MP0004859_abnormal_synaptic_plasticity0.93809534
115MP0004147_increased_porphyrin_level0.93133673
116MP0003943_abnormal_hepatobiliary_system0.92509066
117MP0002896_abnormal_bone_mineralization0.90262284
118MP0002086_abnormal_extraembryonic_tissu0.89954488
119MP0009785_altered_susceptibility_to0.89687064
120MP0004947_skin_inflammation0.88385108
121MP0002928_abnormal_bile_duct0.88005317
122MP0004270_analgesia0.86517254
123MP0002254_reproductive_system_inflammat0.86175865
124MP0010678_abnormal_skin_adnexa0.85438873
125MP0000003_abnormal_adipose_tissue0.85416551
126MP0006054_spinal_hemorrhage0.85234122
127MP0003567_abnormal_fetal_cardiomyocyte0.84829414
128MP0003303_peritoneal_inflammation0.84496455
129MP0002148_abnormal_hypersensitivity_rea0.84377562
130MP0000428_abnormal_craniofacial_morphol0.84109287
131MP0002019_abnormal_tumor_incidence0.83469799
132MP0003075_altered_response_to0.83246543
133MP0005334_abnormal_fat_pad0.81915808
134MP0004264_abnormal_extraembryonic_tissu0.81780601
135MP0001845_abnormal_inflammatory_respons0.81536820
136MP0008961_abnormal_basal_metabolism0.81386413
137MP0003186_abnormal_redox_activity0.80812082
138MP0004858_abnormal_nervous_system0.80547790
139MP0005408_hypopigmentation0.80283440
140MP0010155_abnormal_intestine_physiology0.80024187
141MP0005621_abnormal_cell_physiology0.79931522
142MP0005448_abnormal_energy_balance0.79150680
143MP0000598_abnormal_liver_morphology0.78910708
144MP0003221_abnormal_cardiomyocyte_apopto0.77295264
145MP0002095_abnormal_skin_pigmentation0.76823376
146MP0003633_abnormal_nervous_system0.76529718
147MP0003448_altered_tumor_morphology0.75871373
148MP0000230_abnormal_systemic_arterial0.75583277
149MP0009642_abnormal_blood_homeostasis0.75412054
150MP0005397_hematopoietic_system_phenotyp0.75145947
151MP0001545_abnormal_hematopoietic_system0.75145947
152MP0001501_abnormal_sleep_pattern0.75078201
153MP0009764_decreased_sensitivity_to0.74032791
154MP0003941_abnormal_skin_development0.73862806
155MP0003953_abnormal_hormone_level0.73805855
156MP0002822_catalepsy0.73471132
157MP0006036_abnormal_mitochondrial_physio0.73434768
158MP0001764_abnormal_homeostasis0.73162133
159MP0002084_abnormal_developmental_patter0.72885893
160MP0001697_abnormal_embryo_size0.72699000
161MP0002971_abnormal_brown_adipose0.71786855
162MP0005666_abnormal_adipose_tissue0.71242012
163MP0005275_abnormal_skin_tensile0.70877071
164MP0001853_heart_inflammation0.70569947
165MP0001299_abnormal_eye_distance/0.70487056
166MP0000427_abnormal_hair_cycle0.68746577
167MP0005166_decreased_susceptibility_to0.66753896
168MP0005670_abnormal_white_adipose0.66656883
169MP0002090_abnormal_vision0.65618477
170MP0009384_cardiac_valve_regurgitation0.64359524
171MP0005375_adipose_tissue_phenotype0.63683673
172MP0008469_abnormal_protein_level0.62904199
173MP0003283_abnormal_digestive_organ0.62608447
174MP0002136_abnormal_kidney_physiology0.62262201
175MP0000639_abnormal_adrenal_gland0.61795659
176MP0002735_abnormal_chemical_nociception0.61080706
177MP0003959_abnormal_lean_body0.60840711
178MP0009763_increased_sensitivity_to0.60581944
179MP0002733_abnormal_thermal_nociception0.59907684
180MP0001533_abnormal_skeleton_physiology0.59657244
181MP0005646_abnormal_pituitary_gland0.59231856
182MP0000538_abnormal_urinary_bladder0.58493447
183MP0002168_other_aberrant_phenotype0.57890938
184MP0009765_abnormal_xenobiotic_induced0.57517568
185MP0003724_increased_susceptibility_to0.56898362
186MP0001177_atelectasis0.56337930

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.65046999
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.58865886
3Intrahepatic cholestasis (HP:0001406)4.57496973
4Deep venous thrombosis (HP:0002625)4.28649628
5Xanthomatosis (HP:0000991)4.21295801
6Abnormality of T cell number (HP:0011839)4.16041207
7Hypoglycemic coma (HP:0001325)4.07709797
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90993872
9Ketoacidosis (HP:0001993)3.76525001
10Ketosis (HP:0001946)3.62228594
11Hypobetalipoproteinemia (HP:0003563)3.48841382
12Volvulus (HP:0002580)3.47266743
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.46442913
14Complement deficiency (HP:0004431)3.29016987
15Hypoglycemic seizures (HP:0002173)3.20290119
16Abnormality of the common coagulation pathway (HP:0010990)3.15058978
17Abnormality of T cells (HP:0002843)3.12269750
18Gonadal dysgenesis (HP:0000133)3.10167707
19Epidermoid cyst (HP:0200040)3.05180647
20Embryonal renal neoplasm (HP:0011794)3.04720755
21Papillary thyroid carcinoma (HP:0002895)3.01037755
22Acute myeloid leukemia (HP:0004808)2.99878219
23Hyperammonemia (HP:0001987)2.99159118
24Gout (HP:0001997)2.95531269
25Prolonged partial thromboplastin time (HP:0003645)2.92307237
26Abnormality of the intrinsic pathway (HP:0010989)2.91831259
27Abnormality of B cell number (HP:0010975)2.89883462
28Hypolipoproteinemia (HP:0010981)2.88393406
29Nephroblastoma (Wilms tumor) (HP:0002667)2.88273375
30Eczematoid dermatitis (HP:0000976)2.87815538
31Hyperlipoproteinemia (HP:0010980)2.87087833
32Reduced antithrombin III activity (HP:0001976)2.83175191
33Abnormality of the lumbar spine (HP:0100712)2.82671110
34Conjugated hyperbilirubinemia (HP:0002908)2.82112524
35Abnormality of oral frenula (HP:0000190)2.81321374
36Fat malabsorption (HP:0002630)2.78310452
37B lymphocytopenia (HP:0010976)2.76477037
38Skin nodule (HP:0200036)2.75787942
39IgM deficiency (HP:0002850)2.75010929
40Spontaneous hematomas (HP:0007420)2.73928362
41Abnormality of purine metabolism (HP:0004352)2.73847335
42Hyperinsulinemic hypoglycemia (HP:0000825)2.70457119
43Hypoalphalipoproteinemia (HP:0003233)2.68956014
44Gonadotropin excess (HP:0000837)2.66572847
45Abnormality of proline metabolism (HP:0010907)2.64800385
46Hydroxyprolinuria (HP:0003080)2.64800385
47Abnormality of sulfur amino acid metabolism (HP:0004339)2.59358307
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.58889619
49Pheochromocytoma (HP:0002666)2.58415305
50Abnormality of fatty-acid metabolism (HP:0004359)2.58052491
51Abnormal platelet volume (HP:0011876)2.57692787
52Renal cortical cysts (HP:0000803)2.57373036
53Hyperglycinuria (HP:0003108)2.56146516
54Abnormality of chromosome stability (HP:0003220)2.55909759
55Stomatitis (HP:0010280)2.55068242
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54183730
57Ocular albinism (HP:0001107)2.53894522
58Abnormality of serine family amino acid metabolism (HP:0010894)2.52993161
59Abnormality of glycine metabolism (HP:0010895)2.52993161
60Abnormality of the prostate (HP:0008775)2.52823565
61Sensorimotor neuropathy (HP:0007141)2.52325440
62Autoimmune hemolytic anemia (HP:0001890)2.51488722
63Hyperglycinemia (HP:0002154)2.51395568
64Increased mean platelet volume (HP:0011877)2.50367335
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.49358611
66Combined immunodeficiency (HP:0005387)2.49284430
67Papilledema (HP:0001085)2.47992627
68Prostate neoplasm (HP:0100787)2.47547723
69Symptomatic seizures (HP:0011145)2.47206709
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.47163175
71Hypoplasia of the fovea (HP:0007750)2.47163175
72Chromsome breakage (HP:0040012)2.44694955
73Abnormal auditory evoked potentials (HP:0006958)2.44087723
74Facial hemangioma (HP:0000329)2.44067666
75Thoracolumbar scoliosis (HP:0002944)2.43214935
76Thyroid carcinoma (HP:0002890)2.42851098
77Hyperglycemia (HP:0003074)2.37557994
78Iris hypopigmentation (HP:0007730)2.36725916
79Capillary hemangiomas (HP:0005306)2.36260989
80Protuberant abdomen (HP:0001538)2.35970259
81Mitral stenosis (HP:0001718)2.34748108
82Stomach cancer (HP:0012126)2.33774594
83Abnormality of complement system (HP:0005339)2.32399797
84Mucopolysacchariduria (HP:0008155)2.32281023
85Urinary glycosaminoglycan excretion (HP:0003541)2.32281023
86Recurrent abscess formation (HP:0002722)2.29472657
87Generalized aminoaciduria (HP:0002909)2.28469306
88Aplasia/Hypoplasia of the macula (HP:0008059)2.28197750
89Neuroendocrine neoplasm (HP:0100634)2.27643846
90Abnormality of the fovea (HP:0000493)2.26151921
91Recurrent bacterial skin infections (HP:0005406)2.26003154
92Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25747882
93Abnormal delayed hypersensitivity skin test (HP:0002963)2.25204912
94Abnormality of methionine metabolism (HP:0010901)2.23859688
95Dysostosis multiplex (HP:0000943)2.23462591
96Hyperbilirubinemia (HP:0002904)2.23300653
97Prolonged bleeding time (HP:0003010)2.21186393
98Hepatocellular carcinoma (HP:0001402)2.20307196
99Dyschromatopsia (HP:0007641)2.19524937
100Conjunctival telangiectasia (HP:0000524)2.16502559
101Severe combined immunodeficiency (HP:0004430)2.16430281
102Ovarian neoplasm (HP:0100615)2.15952487
103Abnormality of T cell physiology (HP:0011840)2.15361448
104Resting tremor (HP:0002322)2.14997616
105Abnormality of nucleobase metabolism (HP:0010932)2.14257861
106Myocardial infarction (HP:0001658)2.12417763
107Ankyloglossia (HP:0010296)2.11785246
108Biliary tract neoplasm (HP:0100574)2.10371381
109Retrobulbar optic neuritis (HP:0100654)2.08720875
110Optic neuritis (HP:0100653)2.08720875
111Abnormal lung lobation (HP:0002101)2.08661619
112Encephalitis (HP:0002383)2.07925236
113Abnormality of polysaccharide metabolism (HP:0011012)2.07335025
114Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07335025
115Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07335025
116IgG deficiency (HP:0004315)2.07007760
117Abnormality of macrophages (HP:0004311)2.06762771
118Recurrent viral infections (HP:0004429)2.06511648
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.06049520
120Albinism (HP:0001022)2.05197085
121Abnormality of the vasculature of the conjunctiva (HP:0008054)2.03446577
122Hypercholesterolemia (HP:0003124)2.02655800
123Abnormal gallbladder morphology (HP:0012437)2.02231836
124Panhypogammaglobulinemia (HP:0003139)2.01125706
125Myositis (HP:0100614)2.01102343
126Aplasia/Hypoplasia affecting the retina (HP:0008061)2.00810181
127Spastic diplegia (HP:0001264)1.99896543
128Chronic diarrhea (HP:0002028)1.99754091
129Testicular neoplasm (HP:0010788)1.99019386
130Irritability (HP:0000737)1.98530734
131Intestinal atresia (HP:0011100)1.95453949
132Joint hemorrhage (HP:0005261)1.94767988
133Gingival bleeding (HP:0000225)1.93618551
134Recurrent fungal infections (HP:0002841)1.91963518
135Periodontitis (HP:0000704)1.91886316
136Hyperuricemia (HP:0002149)1.90929623
137Increased purine levels (HP:0004368)1.90929623
138Metabolic acidosis (HP:0001942)1.90614367
139Systemic lupus erythematosus (HP:0002725)1.90465408
140Deviation of the thumb (HP:0009603)1.90070114
141Keratoconjunctivitis sicca (HP:0001097)1.90038244
142Neoplasm of the colon (HP:0100273)1.89939051
143Abnormal tarsal ossification (HP:0008369)1.89700046
144Neonatal onset (HP:0003623)1.89237747
145Neoplasm of the small intestine (HP:0100833)1.88856397
146Abnormality of male internal genitalia (HP:0000022)1.88805006
147Proximal placement of thumb (HP:0009623)1.88636904
148Clitoromegaly (HP:0000057)1.88526069
149Cerebral hemorrhage (HP:0001342)1.88117662
150Long toe (HP:0010511)1.84499937
151Acanthocytosis (HP:0001927)1.83949942
152Central scotoma (HP:0000603)1.83720238
153Abnormal cartilage morphology (HP:0002763)1.81779628
154Pancreatitis (HP:0001733)1.81714458
155Steatorrhea (HP:0002570)1.81677926
156IgA deficiency (HP:0002720)1.80698196
157Joint swelling (HP:0001386)1.79837429
158Conjunctival hamartoma (HP:0100780)1.79696422
159Cholelithiasis (HP:0001081)1.79313291
160Anhidrosis (HP:0000970)1.78831384
161Myelodysplasia (HP:0002863)1.78727121
162Lymphoma (HP:0002665)1.78496055
163Keratoconjunctivitis (HP:0001096)1.78193954
164Arterial thrombosis (HP:0004420)1.78161986
165Patchy hypopigmentation of hair (HP:0011365)1.77635365
166Orchitis (HP:0100796)1.76681631
167Abnormality of vitamin B metabolism (HP:0004340)1.75751356
168Abnormality of the vitamin B12 metabolism (HP:0004341)1.74815206
169Lower limb hyperreflexia (HP:0002395)1.73284551
170Epistaxis (HP:0000421)1.73191859
171Abnormality of serum amino acid levels (HP:0003112)1.72994817
172Abnormality of the columella (HP:0009929)1.72689038
173Insulin-resistant diabetes mellitus (HP:0000831)1.71044042
174Methylmalonic acidemia (HP:0002912)1.70828918
175Lymphopenia (HP:0001888)1.70575039
176Oligomenorrhea (HP:0000876)1.70320736
177Alkalosis (HP:0001948)1.70275714
178Rhabdomyosarcoma (HP:0002859)1.69984871
179Abnormality of endocrine pancreas physiology (HP:0012093)1.68615909
180Abnormality of the pancreatic islet cells (HP:0006476)1.68615909
181Increased CSF protein (HP:0002922)1.65937892
182Myoglobinuria (HP:0002913)1.65915029
183Amyloidosis (HP:0011034)1.65848856
184Late onset (HP:0003584)1.63970070
185Delayed CNS myelination (HP:0002188)1.63710793
186Acute hepatic failure (HP:0006554)1.61505700
187Esophageal varix (HP:0002040)1.60853057
188Tetraplegia (HP:0002445)1.60819620
189Global brain atrophy (HP:0002283)1.60738516
190Abnormal enzyme/coenzyme activity (HP:0012379)1.60513999
191Death in childhood (HP:0003819)1.60125748
192Hypokalemic alkalosis (HP:0001949)1.58823731
193Abdominal distention (HP:0003270)1.58536010
194Status epilepticus (HP:0002133)1.57658103
195Abnormal foot bone ossification (HP:0010675)1.56521247
196Abnormality of the gallbladder (HP:0005264)1.55607746

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.56557129
2MAP3K23.29393115
3FRK3.11122150
4ACVR1B2.92166387
5INSRR2.83083353
6SCYL22.72090436
7NUAK12.64246771
8ERN12.58759856
9BCKDK2.47387429
10CAMKK22.29509635
11EIF2AK32.29164578
12NTRK32.22073406
13MAP4K12.14678732
14TRIB32.13681500
15KSR22.06229344
16TEC1.98306296
17BMPR21.95355410
18PKN21.94839273
19MKNK11.94460351
20SIK11.85782931
21MAP2K41.84008888
22TTK1.81807891
23CAMKK11.73796001
24CDK61.69907766
25PLK41.69141502
26FGFR41.68681829
27STK31.67230105
28NTRK11.59631216
29LMTK21.57830948
30SIK31.55351156
31WEE11.55295932
32FES1.54361870
33RET1.53222956
34PTK61.51558613
35RIPK11.49559591
36MKNK21.48728003
37ZAP701.47368143
38PAK31.46659957
39PDGFRA1.45760646
40PDK31.43773340
41PDK41.43773340
42PRKCH1.43494023
43NEK91.42246049
44TAOK31.41769899
45MAP3K91.41224358
46JAK11.39450115
47BRD41.38124720
48MINK11.32626245
49TNIK1.31868150
50ERBB41.28766536
51WNK41.28429023
52PRKD31.25498590
53TRIM281.24597299
54NLK1.23330736
55MST1R1.19380336
56DAPK21.14877781
57RIPK41.13969604
58WNK31.13644383
59PLK31.13290134
60MAP2K11.13029209
61FER1.11897306
62YES11.11516807
63GRK61.11308588
64JAK21.10952269
65JAK31.10425541
66MAP3K41.07031404
67SGK31.06931631
68PBK1.06508162
69SYK1.06402455
70PIM11.05416113
71FGFR31.04527415
72PDK21.04242522
73BTK1.00229772
74PAK60.94288141
75CSK0.93668955
76MAP3K30.92836771
77MAP3K10.91904557
78PDPK10.91372762
79STK100.91012603
80PDK10.90341843
81MARK30.89510670
82MAP4K20.88326559
83LATS10.87898453
84FGFR20.87813564
85CDK40.87736717
86NEK60.87567475
87PTK20.86034476
88PRPF4B0.85538626
89WNK10.85228252
90TAF10.84982709
91CDC70.84966046
92EPHA30.83733388
93STK40.83158517
94EIF2AK20.81776928
95MAP3K120.81583651
96FGR0.79947982
97SGK20.79762586
98DDR20.79229281
99TGFBR20.78689773
100ERBB30.77798876
101FLT30.76140596
102NEK10.75689424
103KSR10.74391739
104MAP3K130.72788552
105LCK0.71486248
106CDK120.71445093
107LYN0.70687073
108HCK0.70295380
109OXSR10.69754463
110MST40.69585287
111SGK4940.69527661
112SGK2230.69527661
113CAMK1D0.68819326
114ITK0.66998097
115ABL20.66916837
116LIMK10.65510499
117MAP3K140.62806561
118TYK20.62572107
119LRRK20.61297817
120IGF1R0.59510025
121CHEK20.59370430
122MATK0.59270267
123STK240.58525313
124BMPR1B0.58308007
125MAP2K70.58303312
126MELK0.57362541
127MAP2K20.56617481
128ARAF0.56038534
129TNK20.56008590
130BRSK20.55960424
131RPS6KA40.55934943
132GRK50.54919828
133HIPK20.54287233
134SRPK10.53975653
135ZAK0.53576177
136PRKACG0.53180591
137PRKAA20.53108300
138TRPM70.52910117
139PDGFRB0.52699558
140MAP2K30.52662676
141ALK0.51858979
142TESK10.51821758
143ATM0.51421461
144PLK20.50968246
145IKBKE0.48838759
146CDK50.48765672
147KIT0.48600484
148CHEK10.48255130
149PRKCE0.48179873
150CAMK2G0.48112104
151TSSK60.47952569
152CSNK1G20.47159523
153ATR0.47130718
154STK380.46030317
155MAP3K70.45699754
156PRKAA10.45473562
157MET0.45068989
158PRKCG0.44063025
159RAF10.43642286
160EGFR0.42993974
161PIK3CG0.42613430
162TBK10.42359080
163RPS6KA20.40748692
164MAP2K60.40331399
165PRKCZ0.39995188
166PLK10.39109462
167PRKCQ0.39074442
168IRAK40.38226181
169GSK3A0.35986716

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.40300154
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.95289450
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.76327137
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48669259
5T cell receptor signaling pathway_Homo sapiens_hsa046602.39128938
6Cell cycle_Homo sapiens_hsa041102.36956615
7Sulfur metabolism_Homo sapiens_hsa009202.35989765
8Arginine biosynthesis_Homo sapiens_hsa002202.25908952
9Fatty acid degradation_Homo sapiens_hsa000712.25214245
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22818606
11Butanoate metabolism_Homo sapiens_hsa006502.14628929
12Tryptophan metabolism_Homo sapiens_hsa003802.12484922
13Non-homologous end-joining_Homo sapiens_hsa034502.12293054
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09022961
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.08320129
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.05043666
17Propanoate metabolism_Homo sapiens_hsa006402.01807608
18Platelet activation_Homo sapiens_hsa046111.99706351
19Primary immunodeficiency_Homo sapiens_hsa053401.96734721
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.95345602
21Caffeine metabolism_Homo sapiens_hsa002321.87898708
22Mismatch repair_Homo sapiens_hsa034301.79142185
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.78775193
24Measles_Homo sapiens_hsa051621.77143935
25Basal transcription factors_Homo sapiens_hsa030221.74318401
26Inositol phosphate metabolism_Homo sapiens_hsa005621.71351455
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68674904
28Fatty acid metabolism_Homo sapiens_hsa012121.65647881
29Complement and coagulation cascades_Homo sapiens_hsa046101.64809450
30B cell receptor signaling pathway_Homo sapiens_hsa046621.64427645
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63578589
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63013162
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59909025
34Pancreatic cancer_Homo sapiens_hsa052121.59195445
35Thyroid cancer_Homo sapiens_hsa052161.58669780
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57191740
37Peroxisome_Homo sapiens_hsa041461.55578815
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.55006117
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.53351871
40Non-small cell lung cancer_Homo sapiens_hsa052231.52887474
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51970293
42Osteoclast differentiation_Homo sapiens_hsa043801.50087206
43Hematopoietic cell lineage_Homo sapiens_hsa046401.47869469
44Bile secretion_Homo sapiens_hsa049761.46450685
45Prostate cancer_Homo sapiens_hsa052151.45154070
46PPAR signaling pathway_Homo sapiens_hsa033201.44766407
47Chronic myeloid leukemia_Homo sapiens_hsa052201.43693265
48Pyruvate metabolism_Homo sapiens_hsa006201.42968580
49Herpes simplex infection_Homo sapiens_hsa051681.42554423
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40770339
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.36674684
52Phenylalanine metabolism_Homo sapiens_hsa003601.35222245
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.33304162
54Starch and sucrose metabolism_Homo sapiens_hsa005001.33072833
55Histidine metabolism_Homo sapiens_hsa003401.30593293
56beta-Alanine metabolism_Homo sapiens_hsa004101.26886417
57Hepatitis B_Homo sapiens_hsa051611.26591380
58Colorectal cancer_Homo sapiens_hsa052101.26579911
59RNA transport_Homo sapiens_hsa030131.22418672
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21939587
61mRNA surveillance pathway_Homo sapiens_hsa030151.20040953
62Oocyte meiosis_Homo sapiens_hsa041141.18957336
63p53 signaling pathway_Homo sapiens_hsa041151.18006070
64Acute myeloid leukemia_Homo sapiens_hsa052211.17675938
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17504207
66Legionellosis_Homo sapiens_hsa051341.16109823
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13267356
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11892662
69Selenocompound metabolism_Homo sapiens_hsa004501.11765688
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11108155
71Homologous recombination_Homo sapiens_hsa034401.09673016
72Fat digestion and absorption_Homo sapiens_hsa049751.04533245
73Carbon metabolism_Homo sapiens_hsa012001.02709746
74Graft-versus-host disease_Homo sapiens_hsa053321.02556455
75Chemical carcinogenesis_Homo sapiens_hsa052041.02452753
76Protein export_Homo sapiens_hsa030601.02449333
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01491308
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00976023
79RNA degradation_Homo sapiens_hsa030180.99960838
80Chemokine signaling pathway_Homo sapiens_hsa040620.99189726
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98418850
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.98328964
83Tyrosine metabolism_Homo sapiens_hsa003500.97862763
84Viral carcinogenesis_Homo sapiens_hsa052030.96809873
85Staphylococcus aureus infection_Homo sapiens_hsa051500.96139207
86Leishmaniasis_Homo sapiens_hsa051400.95019971
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93572534
88Circadian rhythm_Homo sapiens_hsa047100.91627043
89Small cell lung cancer_Homo sapiens_hsa052220.91341015
90ABC transporters_Homo sapiens_hsa020100.90803635
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87177019
92Synaptic vesicle cycle_Homo sapiens_hsa047210.86793003
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.85678515
94MicroRNAs in cancer_Homo sapiens_hsa052060.85492731
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.84024762
96Autoimmune thyroid disease_Homo sapiens_hsa053200.83477312
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82942422
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80102146
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79045000
100FoxO signaling pathway_Homo sapiens_hsa040680.78625755
101Type II diabetes mellitus_Homo sapiens_hsa049300.78514913
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78440014
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.77250408
104Dorso-ventral axis formation_Homo sapiens_hsa043200.76044576
105Adherens junction_Homo sapiens_hsa045200.75863216
106Antigen processing and presentation_Homo sapiens_hsa046120.75554789
107Prolactin signaling pathway_Homo sapiens_hsa049170.74802269
108Insulin resistance_Homo sapiens_hsa049310.73802681
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73262116
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73176767
111Fatty acid elongation_Homo sapiens_hsa000620.72299291
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72213507
113Steroid biosynthesis_Homo sapiens_hsa001000.71715297
114Glioma_Homo sapiens_hsa052140.71194243
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70557658
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70211731
117Insulin secretion_Homo sapiens_hsa049110.69431866
118Allograft rejection_Homo sapiens_hsa053300.69313355
119Tuberculosis_Homo sapiens_hsa051520.69069395
120TGF-beta signaling pathway_Homo sapiens_hsa043500.68946565
121Influenza A_Homo sapiens_hsa051640.68710295
122Renal cell carcinoma_Homo sapiens_hsa052110.68213399
123Lysosome_Homo sapiens_hsa041420.67847032
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67048182
125HTLV-I infection_Homo sapiens_hsa051660.66017502
126Retinol metabolism_Homo sapiens_hsa008300.65386187
127Endometrial cancer_Homo sapiens_hsa052130.63351175
128TNF signaling pathway_Homo sapiens_hsa046680.63207149
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63088293
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62370223
131Shigellosis_Homo sapiens_hsa051310.62182301
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62128745
133Vibrio cholerae infection_Homo sapiens_hsa051100.62093858
134Apoptosis_Homo sapiens_hsa042100.61822400
135Biosynthesis of amino acids_Homo sapiens_hsa012300.61238110
136Glycerolipid metabolism_Homo sapiens_hsa005610.61110624
137Thyroid hormone synthesis_Homo sapiens_hsa049180.60188833
138Prion diseases_Homo sapiens_hsa050200.59067323
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.59047922
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.57110567
141Choline metabolism in cancer_Homo sapiens_hsa052310.57031665
142Fanconi anemia pathway_Homo sapiens_hsa034600.55998357
143Glucagon signaling pathway_Homo sapiens_hsa049220.55490344
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.55282886
145Ether lipid metabolism_Homo sapiens_hsa005650.53991122
146Collecting duct acid secretion_Homo sapiens_hsa049660.52416011
147Type I diabetes mellitus_Homo sapiens_hsa049400.51453534
148Spliceosome_Homo sapiens_hsa030400.50681823
149Toxoplasmosis_Homo sapiens_hsa051450.50552113
150Fatty acid biosynthesis_Homo sapiens_hsa000610.50443033
151N-Glycan biosynthesis_Homo sapiens_hsa005100.49493760
152Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48289679
153Galactose metabolism_Homo sapiens_hsa000520.48068760
154Nucleotide excision repair_Homo sapiens_hsa034200.47903886
155Malaria_Homo sapiens_hsa051440.47323105
156Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46758402
157Phospholipase D signaling pathway_Homo sapiens_hsa040720.46342832
158GABAergic synapse_Homo sapiens_hsa047270.43480319
159Epstein-Barr virus infection_Homo sapiens_hsa051690.42719295
160Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42583783
161Insulin signaling pathway_Homo sapiens_hsa049100.42315067
162Arginine and proline metabolism_Homo sapiens_hsa003300.41516697
163Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39475216
164Folate biosynthesis_Homo sapiens_hsa007900.38403972
165Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38330604
166Vitamin digestion and absorption_Homo sapiens_hsa049770.38319615
167Melanoma_Homo sapiens_hsa052180.36339022
168Long-term potentiation_Homo sapiens_hsa047200.34728104
169Lysine degradation_Homo sapiens_hsa003100.33205794
170Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32932096
171Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31506828
172Pancreatic secretion_Homo sapiens_hsa049720.30867783
173AMPK signaling pathway_Homo sapiens_hsa041520.30657607
174Dopaminergic synapse_Homo sapiens_hsa047280.29478549
175Amphetamine addiction_Homo sapiens_hsa050310.29056177
176Protein digestion and absorption_Homo sapiens_hsa049740.29003085
177Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28031256
178Cocaine addiction_Homo sapiens_hsa050300.26347105
179Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26138697
180Gastric acid secretion_Homo sapiens_hsa049710.25633627
181Phagosome_Homo sapiens_hsa041450.24820960
182Renin-angiotensin system_Homo sapiens_hsa046140.22292153
183Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21027080
184Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20976337
185Renin secretion_Homo sapiens_hsa049240.20635179
186Central carbon metabolism in cancer_Homo sapiens_hsa052300.20296501
187Amoebiasis_Homo sapiens_hsa051460.19005213
188Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18872463
189Estrogen signaling pathway_Homo sapiens_hsa049150.18861219
190Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18718494

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