SAFB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.09692998
23-UTR-mediated mRNA stabilization (GO:0070935)4.63012750
3negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.19850968
4peptidyl-lysine dimethylation (GO:0018027)4.04690228
5DNA topological change (GO:0006265)4.01968723
6negative regulation of histone methylation (GO:0031061)3.80355103
7heterochromatin organization (GO:0070828)3.71141959
8positive regulation of histone deacetylation (GO:0031065)3.62774194
9COPI coating of Golgi vesicle (GO:0048205)3.62732193
10Golgi transport vesicle coating (GO:0048200)3.62732193
11regulation of RNA export from nucleus (GO:0046831)3.59630543
12negative regulation of mRNA processing (GO:0050686)3.59353592
13dosage compensation (GO:0007549)3.57210343
14histone H3-K36 demethylation (GO:0070544)3.55292613
15mRNA stabilization (GO:0048255)3.48729736
16RNA stabilization (GO:0043489)3.48729736
17nuclear pore complex assembly (GO:0051292)3.47345929
18negative regulation of RNA splicing (GO:0033119)3.44394448
19regulation of translational fidelity (GO:0006450)3.40051105
20regulation of hippo signaling (GO:0035330)3.39782987
21negative regulation of erythrocyte differentiation (GO:0045647)3.39132206
22pore complex assembly (GO:0046931)3.37014207
23negative regulation of mRNA metabolic process (GO:1903312)3.34808858
24positive regulation of RNA splicing (GO:0033120)3.30771610
25histone H2B ubiquitination (GO:0033523)3.30074144
26regulation of chromatin binding (GO:0035561)3.29983493
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.26301782
28protein-DNA complex disassembly (GO:0032986)3.24588130
29nucleosome disassembly (GO:0006337)3.24588130
30nuclear pore organization (GO:0006999)3.24346477
31glucocorticoid receptor signaling pathway (GO:0042921)3.23360151
32negative regulation of cell size (GO:0045792)3.23120362
33chromatin silencing (GO:0006342)3.23059013
34cellular hyperosmotic response (GO:0071474)3.19960790
35DNA unwinding involved in DNA replication (GO:0006268)3.19318992
36paraxial mesoderm development (GO:0048339)3.17663235
37cytoplasmic mRNA processing body assembly (GO:0033962)3.17311571
38sister chromatid segregation (GO:0000819)3.16162790
39spliceosomal tri-snRNP complex assembly (GO:0000244)3.16154737
40histone H3-K4 methylation (GO:0051568)3.12897669
41regulation of translational termination (GO:0006449)3.12536305
42histone H4-K12 acetylation (GO:0043983)3.09186155
43positive regulation of gene expression, epigenetic (GO:0045815)3.08158773
44stress granule assembly (GO:0034063)3.07899953
45establishment of apical/basal cell polarity (GO:0035089)3.07637717
46* intracellular estrogen receptor signaling pathway (GO:0030520)3.06189006
47establishment of integrated proviral latency (GO:0075713)3.05776342
48formation of translation preinitiation complex (GO:0001731)3.05553994
49regulation of NFAT protein import into nucleus (GO:0051532)3.02405662
50retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.01622754
51pentose-phosphate shunt (GO:0006098)3.01309295
52protein export from nucleus (GO:0006611)3.00939552
53planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99186875
54negative regulation of gene expression, epigenetic (GO:0045814)2.97572443
55histone H4-K16 acetylation (GO:0043984)2.96465147
56regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.96292805
57regulation of nucleobase-containing compound transport (GO:0032239)2.96276695
58mitotic sister chromatid segregation (GO:0000070)2.95709276
59mRNA splicing, via spliceosome (GO:0000398)2.94409164
60RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94409164
61regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.93947570
62NLS-bearing protein import into nucleus (GO:0006607)2.93938733
63protein localization to kinetochore (GO:0034501)2.92907613
64RNA localization (GO:0006403)2.92600475
65histone H4-K8 acetylation (GO:0043982)2.92390809
66histone H4-K5 acetylation (GO:0043981)2.92390809
67gene silencing (GO:0016458)2.91953383
68histone demethylation (GO:0016577)2.91585160
69polarized epithelial cell differentiation (GO:0030859)2.91577545
70histone lysine demethylation (GO:0070076)2.91189498
71positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.91162171
72mitotic sister chromatid cohesion (GO:0007064)2.89784513
73positive regulation of DNA-templated transcription, elongation (GO:0032786)2.89374268
74regulation of histone H3-K27 methylation (GO:0061085)2.88476026
75mitotic G1 DNA damage checkpoint (GO:0031571)2.87890016
76regulation of mammary gland epithelial cell proliferation (GO:0033599)2.86728003
77RNA splicing, via transesterification reactions (GO:0000375)2.83738019
78protein complex localization (GO:0031503)2.83518458
79regulation of sister chromatid cohesion (GO:0007063)2.82147901
80adherens junction assembly (GO:0034333)2.81765621
81peptidyl-arginine omega-N-methylation (GO:0035247)2.80902129
82trophectodermal cell differentiation (GO:0001829)2.79752309
83regulation of histone H3-K9 methylation (GO:0051570)2.79286246
84mRNA splice site selection (GO:0006376)2.78455181
85regulation of mRNA stability (GO:0043488)2.77844175
86cellular response to virus (GO:0098586)2.77611636
87regulation of gene silencing by RNA (GO:0060966)2.77605475
88regulation of posttranscriptional gene silencing (GO:0060147)2.77605475
89regulation of gene silencing by miRNA (GO:0060964)2.77605475
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.77066899
91regulation of DNA-templated transcription, elongation (GO:0032784)2.76312383
92apoptotic process involved in morphogenesis (GO:0060561)2.75797098
93maternal placenta development (GO:0001893)2.75522986
94histone arginine methylation (GO:0034969)2.74611902
95establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.74564707
96mitotic chromosome condensation (GO:0007076)2.73415755
97alternative mRNA splicing, via spliceosome (GO:0000380)2.72868663
98histone H3-K9 demethylation (GO:0033169)2.72176837
99regulation of DNA damage checkpoint (GO:2000001)2.71945096
100protein localization to endosome (GO:0036010)2.71492771
101chromatin assembly (GO:0031497)2.70749162
102positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.70626942
103histone lysine methylation (GO:0034968)2.70212461
104DNA duplex unwinding (GO:0032508)2.70004759
105mRNA transport (GO:0051028)2.69587379
106glial cell proliferation (GO:0014009)2.67409883
107DNA geometric change (GO:0032392)2.66418409
108protein demethylation (GO:0006482)2.66241114
109protein dealkylation (GO:0008214)2.66241114
110negative regulation of histone modification (GO:0031057)2.63652260
111DNA replication initiation (GO:0006270)2.63569443
112regulation of type I interferon-mediated signaling pathway (GO:0060338)2.62958305
113DNA strand elongation involved in DNA replication (GO:0006271)2.62936228
114V(D)J recombination (GO:0033151)2.62825502
115peptidyl-arginine methylation (GO:0018216)2.62794565
116peptidyl-arginine N-methylation (GO:0035246)2.62794565
117NADPH regeneration (GO:0006740)2.61266643
118protein retention in ER lumen (GO:0006621)2.60978365
119cellular protein complex localization (GO:0034629)2.60634390
120regulation of RNA stability (GO:0043487)2.59967998
121histone methylation (GO:0016571)2.59867825
122positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.59664490
123regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.59664490
124establishment of nucleus localization (GO:0040023)2.59516420
125negative regulation of DNA-templated transcription, elongation (GO:0032785)2.59289080
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.58832574
127histone H4 acetylation (GO:0043967)2.58301531
128focal adhesion assembly (GO:0048041)2.58215208
129cell-substrate adherens junction assembly (GO:0007045)2.58215208
130insulin-like growth factor receptor signaling pathway (GO:0048009)2.58043372
131nuclear envelope disassembly (GO:0051081)2.56957736
132membrane disassembly (GO:0030397)2.56957736
133histone H4 deacetylation (GO:0070933)2.56724651
134DNA conformation change (GO:0071103)2.56241198
135DNA strand elongation (GO:0022616)2.54550604
136layer formation in cerebral cortex (GO:0021819)2.54089414
137gene silencing by RNA (GO:0031047)2.52097701
138epithelial cell differentiation involved in prostate gland development (GO:0060742)2.51700965
139glucose 6-phosphate metabolic process (GO:0051156)2.51657390
140positive regulation of cell cycle checkpoint (GO:1901978)2.51266188
141positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.50819768
142mitotic G1/S transition checkpoint (GO:0044819)2.50723107
143establishment or maintenance of monopolar cell polarity (GO:0061339)2.50496260
144establishment of monopolar cell polarity (GO:0061162)2.50496260
145gastrulation with mouth forming second (GO:0001702)2.49850902
146mitotic nuclear envelope disassembly (GO:0007077)2.49757001
147histone H3-K4 trimethylation (GO:0080182)2.49370929
148protein localization to chromosome, centromeric region (GO:0071459)2.49287443
149mRNA export from nucleus (GO:0006406)2.48756609
150epithelial cell fate commitment (GO:0072148)2.48596038
151establishment of viral latency (GO:0019043)2.48073643
152negative regulation of nucleotide catabolic process (GO:0030812)2.48002637
153sodium ion export (GO:0071436)2.47115895
154negative regulation of glial cell proliferation (GO:0060253)2.47057815
155G1 DNA damage checkpoint (GO:0044783)2.46799205
156corticosteroid receptor signaling pathway (GO:0031958)2.46719257
157hippo signaling (GO:0035329)2.42363480

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.65747172
2E2F7_22180533_ChIP-Seq_HELA_Human4.59668103
3MYC_22102868_ChIP-Seq_BL_Human3.86009121
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.12672117
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00776550
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.88654906
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.81579654
8KDM2B_26808549_Chip-Seq_DND41_Human2.73619539
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.68757763
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.49566420
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.47828403
12VDR_21846776_ChIP-Seq_THP-1_Human2.45719616
13TCF7_22412390_ChIP-Seq_EML_Mouse2.45064445
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.39095123
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.38210127
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.37029995
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33568575
18ZFP281_27345836_Chip-Seq_ESCs_Mouse2.30560894
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.12009963
20KDM2B_26808549_Chip-Seq_JURKAT_Human1.98165505
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.95331788
22KDM2B_26808549_Chip-Seq_K562_Human1.95188038
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.92855309
24LXR_22292898_ChIP-Seq_THP-1_Human1.90814314
25DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.90199476
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83357100
27CIITA_25753668_ChIP-Seq_RAJI_Human1.81603792
28* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81398893
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.77900876
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75008721
31CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.72198372
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.65421736
33P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59918628
34ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59724664
35CREB1_26743006_Chip-Seq_LNCaP_Human1.59589940
36XRN2_22483619_ChIP-Seq_HELA_Human1.58532386
37UTX_26944678_Chip-Seq_JUKART_Human1.57467906
38ZNF263_19887448_ChIP-Seq_K562_Human1.56781346
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56583324
40RACK7_27058665_Chip-Seq_MCF-7_Human1.55271527
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54132223
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51583792
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51083968
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50867019
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50029319
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49055926
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48484547
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48481922
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47680892
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47071278
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46398848
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.45763733
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45495671
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45413622
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45177227
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.41391573
57MAF_26560356_Chip-Seq_TH1_Human1.37489448
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37067673
59* NCOR1_26117541_ChIP-Seq_K562_Human1.37013677
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36422834
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35810003
62* P68_20966046_ChIP-Seq_HELA_Human1.34932856
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34548757
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33802352
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31816647
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29627611
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.29225738
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.28727668
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28411683
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28411683
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28411683
72* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28330574
73VDR_24763502_ChIP-Seq_THP-1_Human1.27970926
74POU5F1_16518401_ChIP-PET_MESCs_Mouse1.26817228
75PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26050860
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25530538
77* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25527527
78NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.25285399
79ATF3_27146783_Chip-Seq_COLON_Human1.24407856
80RARB_27405468_Chip-Seq_BRAIN_Mouse1.23620329
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22523325
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21687966
83FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21554505
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20162774
85* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19764757
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19646784
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.19394372
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18121769
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17830013
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17297492
91* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16523967
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15991129
93TP53_22127205_ChIP-Seq_IMR90_Human1.15369909
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15043074
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14784995
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.14447525
97KDM5A_27292631_Chip-Seq_BREAST_Human1.13993506
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13058577
99CLOCK_20551151_ChIP-Seq_293T_Human1.13050877
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12686299
101CHD1_26751641_Chip-Seq_LNCaP_Human1.10288933
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09419416
103SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09308645
104CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09267592
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09050766
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08393313
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07825411
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07799571
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06112871
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06090159
111KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05757004
112SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05418612
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04631388
114BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03596633
115MAF_26560356_Chip-Seq_TH2_Human1.03189784
116TET1_21451524_ChIP-Seq_MESCs_Mouse1.02893647
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02681442
118TFEB_21752829_ChIP-Seq_HELA_Human1.02505505
119ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01181471
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00303713
121CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00228714
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.00103361
123GABP_19822575_ChIP-Seq_HepG2_Human0.99829549
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99659444
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99318881
126SA1_27219007_Chip-Seq_ERYTHROID_Human0.98697186
127TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98684876
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97897753
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97480346
130SMC4_20622854_ChIP-Seq_HELA_Human0.96699954
131AR_21909140_ChIP-Seq_LNCAP_Human0.96384331
132MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96288177
133* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95929446
134TP63_17297297_ChIP-ChIP_HaCaT_Human0.94368687
135TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93994089
136* ELF1_20517297_ChIP-Seq_JURKAT_Human0.92856876
137SALL1_21062744_ChIP-ChIP_HESCs_Human0.92304512
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91841923
139* PHF8_20622854_ChIP-Seq_HELA_Human0.91783453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.86974985
2MP0002877_abnormal_melanocyte_morpholog3.36378198
3MP0005451_abnormal_body_composition3.22428022
4MP0005076_abnormal_cell_differentiation3.14023421
5MP0008260_abnormal_autophagy2.80522515
6MP0003283_abnormal_digestive_organ2.76442909
7MP0008961_abnormal_basal_metabolism2.63419549
8MP0003111_abnormal_nucleus_morphology2.47231724
9MP0009278_abnormal_bone_marrow2.31022775
10MP0010030_abnormal_orbit_morphology2.26936491
11MP0010352_gastrointestinal_tract_polyps2.25759863
12MP0002653_abnormal_ependyma_morphology2.16692369
13MP0001849_ear_inflammation2.15481294
14MP0001730_embryonic_growth_arrest2.07995663
15MP0002084_abnormal_developmental_patter2.03875366
16MP0003119_abnormal_digestive_system1.88042219
17MP0000537_abnormal_urethra_morphology1.88008186
18* MP0004197_abnormal_fetal_growth/weight/1.87647057
19MP0003763_abnormal_thymus_physiology1.86941512
20MP0001672_abnormal_embryogenesis/_devel1.85929480
21MP0005380_embryogenesis_phenotype1.85929480
22MP0002009_preneoplasia1.83349081
23MP0003123_paternal_imprinting1.82553717
24MP0003077_abnormal_cell_cycle1.82243619
25MP0002085_abnormal_embryonic_tissue1.82209768
26MP0005058_abnormal_lysosome_morphology1.78845409
27MP0000733_abnormal_muscle_development1.78839439
28MP0003221_abnormal_cardiomyocyte_apopto1.76760550
29MP0003984_embryonic_growth_retardation1.76101103
30MP0002088_abnormal_embryonic_growth/wei1.75299875
31MP0003787_abnormal_imprinting1.74920810
32MP0000350_abnormal_cell_proliferation1.74493842
33MP0002086_abnormal_extraembryonic_tissu1.64744507
34MP0003121_genomic_imprinting1.62562501
35MP0008932_abnormal_embryonic_tissue1.62388371
36MP0010234_abnormal_vibrissa_follicle1.62147129
37MP0008057_abnormal_DNA_replication1.59384652
38MP0001697_abnormal_embryo_size1.58498847
39MP0000428_abnormal_craniofacial_morphol1.58448892
40MP0010094_abnormal_chromosome_stability1.53785058
41MP0004185_abnormal_adipocyte_glucose1.49162213
42MP0009672_abnormal_birth_weight1.48323286
43MP0004957_abnormal_blastocyst_morpholog1.46272817
44MP0000678_abnormal_parathyroid_gland1.45739037
45MP0005621_abnormal_cell_physiology1.44137606
46MP0003890_abnormal_embryonic-extraembry1.42720865
47* MP0002080_prenatal_lethality1.41855636
48MP0004233_abnormal_muscle_weight1.41018168
49MP0010630_abnormal_cardiac_muscle1.40459103
50MP0000858_altered_metastatic_potential1.39051998
51MP0005397_hematopoietic_system_phenotyp1.37996919
52MP0001545_abnormal_hematopoietic_system1.37996919
53MP0010307_abnormal_tumor_latency1.37996813
54MP0003436_decreased_susceptibility_to1.37480363
55MP0003329_amyloid_beta_deposits1.37393234
56MP0009053_abnormal_anal_canal1.37156797
57MP0000751_myopathy1.31209261
58MP0002398_abnormal_bone_marrow1.29053239
59MP0003935_abnormal_craniofacial_develop1.28736656
60MP0005623_abnormal_meninges_morphology1.28146984
61MP0003861_abnormal_nervous_system1.28060171
62MP0004264_abnormal_extraembryonic_tissu1.27717576
63MP0000569_abnormal_digit_pigmentation1.27600612
64MP0001293_anophthalmia1.27232994
65MP0009703_decreased_birth_body1.27041791
66MP0002925_abnormal_cardiovascular_devel1.27023431
67MP0000003_abnormal_adipose_tissue1.26511952
68MP0003567_abnormal_fetal_cardiomyocyte1.25461939
69MP0005187_abnormal_penis_morphology1.24879889
70MP0002234_abnormal_pharynx_morphology1.23611476
71MP0003300_gastrointestinal_ulcer1.22441404
72MP0000490_abnormal_crypts_of1.21906982
73MP0004859_abnormal_synaptic_plasticity1.21691402
74MP0005384_cellular_phenotype1.21383171
75MP0003122_maternal_imprinting1.21166842
76MP0008877_abnormal_DNA_methylation1.20787884
77* MP0003115_abnormal_respiratory_system1.20658907
78MP0002092_abnormal_eye_morphology1.20196059
79MP0002089_abnormal_postnatal_growth/wei1.19978992
80MP0003091_abnormal_cell_migration1.19701015
81MP0004087_abnormal_muscle_fiber1.19251277
82MP0003453_abnormal_keratinocyte_physiol1.19092783
83MP0003172_abnormal_lysosome_physiology1.17312102
84MP0002697_abnormal_eye_size1.17067056
85MP0005375_adipose_tissue_phenotype1.14825918
86MP0003566_abnormal_cell_adhesion1.14716276
87MP0008770_decreased_survivor_rate1.14695522
88MP0004947_skin_inflammation1.13798788
89MP0003693_abnormal_embryo_hatching1.11511239
90MP0004808_abnormal_hematopoietic_stem1.11287194
91MP0001727_abnormal_embryo_implantation1.11064800
92MP0002722_abnormal_immune_system1.09745769
93MP0004084_abnormal_cardiac_muscle1.09729105
94MP0009333_abnormal_splenocyte_physiolog1.08846040
95MP0003656_abnormal_erythrocyte_physiolo1.08707591
96MP0000266_abnormal_heart_morphology1.06083090
97MP0005666_abnormal_adipose_tissue1.05694685
98MP0003385_abnormal_body_wall1.03867060
99MP0002269_muscular_atrophy1.03436499
100MP0004858_abnormal_nervous_system1.03017957
101MP0005248_abnormal_Harderian_gland1.02443848
102MP0005501_abnormal_skin_physiology0.99860761
103MP0008058_abnormal_DNA_repair0.98193158
104MP0002932_abnormal_joint_morphology0.97761659
105MP0002019_abnormal_tumor_incidence0.93065337
106* MP0002429_abnormal_blood_cell0.91956979
107MP0001784_abnormal_fluid_regulation0.91351638
108MP0000703_abnormal_thymus_morphology0.91127357
109MP0000534_abnormal_ureter_morphology0.91111509
110MP0003303_peritoneal_inflammation0.89351176
111MP0002249_abnormal_larynx_morphology0.88611661
112MP0009780_abnormal_chondrocyte_physiolo0.88171991
113MP0000750_abnormal_muscle_regeneration0.87715038
114MP0000716_abnormal_immune_system0.87227020
115MP0000689_abnormal_spleen_morphology0.85872139
116MP0002111_abnormal_tail_morphology0.85449161
117MP0002396_abnormal_hematopoietic_system0.85117843
118MP0000747_muscle_weakness0.84526973
119MP0004133_heterotaxia0.83578862
120MP0001348_abnormal_lacrimal_gland0.79818571
121MP0000313_abnormal_cell_death0.78282538
122MP0002909_abnormal_adrenal_gland0.77807903
123MP0000432_abnormal_head_morphology0.76766130
124MP0003045_fibrosis0.76561932
125* MP0002081_perinatal_lethality0.76231525
126MP0003937_abnormal_limbs/digits/tail_de0.75831303
127MP0001915_intracranial_hemorrhage0.75621467
128MP0005257_abnormal_intraocular_pressure0.75315331
129MP0002152_abnormal_brain_morphology0.74805838
130MP0005499_abnormal_olfactory_system0.74569812
131MP0005394_taste/olfaction_phenotype0.74569812
132MP0002420_abnormal_adaptive_immunity0.74054641
133MP0000358_abnormal_cell_content/0.73803298
134MP0002116_abnormal_craniofacial_bone0.73342404
135MP0005409_darkened_coat_color0.73060034
136MP0004811_abnormal_neuron_physiology0.73033840
137MP0001819_abnormal_immune_cell0.72697854
138MP0002796_impaired_skin_barrier0.71853432
139MP0008007_abnormal_cellular_replicative0.71654826
140MP0003137_abnormal_impulse_conducting0.71550271
141MP0009931_abnormal_skin_appearance0.69838776
142MP0003191_abnormal_cellular_cholesterol0.67101333
143MP0000685_abnormal_immune_system0.67034333

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.17763578
2Abnormality of the lower motor neuron (HP:0002366)3.66656682
3Ependymoma (HP:0002888)3.25888786
4Insomnia (HP:0100785)3.24826223
5Renal duplication (HP:0000075)3.17812025
6Cerebral aneurysm (HP:0004944)3.14508872
7Elfin facies (HP:0004428)3.07166709
8Renovascular hypertension (HP:0100817)2.97756379
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.96436765
10Short 4th metacarpal (HP:0010044)2.96436765
11Pseudobulbar signs (HP:0002200)2.93243782
12Increased nuchal translucency (HP:0010880)2.88785602
13Abnormality of the astrocytes (HP:0100707)2.77507196
14Astrocytoma (HP:0009592)2.77507196
15Abnormality of the fingertips (HP:0001211)2.73823224
16Heterotopia (HP:0002282)2.69984014
17Overriding aorta (HP:0002623)2.69037831
18Shallow orbits (HP:0000586)2.67659354
19Pointed chin (HP:0000307)2.64168255
20Cholecystitis (HP:0001082)2.59444417
21Abnormal gallbladder physiology (HP:0012438)2.59444417
22Peripheral hypomyelination (HP:0007182)2.58724813
23Macroorchidism (HP:0000053)2.57965783
24Neoplasm of the heart (HP:0100544)2.51854629
25Abnormality of the 4th metacarpal (HP:0010012)2.51082265
26Cortical dysplasia (HP:0002539)2.47514006
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.44555667
28High anterior hairline (HP:0009890)2.40101044
29Vertebral arch anomaly (HP:0008438)2.36319527
30Supernumerary ribs (HP:0005815)2.32590739
31Obstructive sleep apnea (HP:0002870)2.30932027
32Distal upper limb amyotrophy (HP:0007149)2.30640396
33Upper limb amyotrophy (HP:0009129)2.30640396
34Abnormality of the calcaneus (HP:0008364)2.27891538
35Obsessive-compulsive behavior (HP:0000722)2.23432864
36Dysmetric saccades (HP:0000641)2.22796861
37Ragged-red muscle fibers (HP:0003200)2.22272133
38Ulnar bowing (HP:0003031)2.19500191
39Long eyelashes (HP:0000527)2.18065119
40Trigonocephaly (HP:0000243)2.16289635
41Hand muscle atrophy (HP:0009130)2.16242750
42Bowel diverticulosis (HP:0005222)2.14760394
43Progressive external ophthalmoplegia (HP:0000590)2.12706226
44Spastic diplegia (HP:0001264)2.12448900
45Reticulocytosis (HP:0001923)2.11047665
46Volvulus (HP:0002580)2.10340479
47Skin tags (HP:0010609)2.10325565
48Distal lower limb amyotrophy (HP:0008944)2.10027933
49Neoplasm of the oral cavity (HP:0100649)2.09009237
50Annular pancreas (HP:0001734)2.08160308
51Hammertoe (HP:0001765)2.07537331
52Flat cornea (HP:0007720)2.06993526
53Cellulitis (HP:0100658)2.06785633
54Rib fusion (HP:0000902)2.05331155
55Cerebral inclusion bodies (HP:0100314)2.05201650
56Abnormality of the diencephalon (HP:0010662)2.04447198
57Ankyloglossia (HP:0010296)2.03524694
58Achilles tendon contracture (HP:0001771)2.03033712
59Back pain (HP:0003418)2.00855179
60Progressive muscle weakness (HP:0003323)2.00293212
61Bowel incontinence (HP:0002607)1.98996438
62Insidious onset (HP:0003587)1.98290542
63Termporal pattern (HP:0011008)1.98290542
64Glioma (HP:0009733)1.98214157
65Aneurysm (HP:0002617)1.98101346
66Disproportionate tall stature (HP:0001519)1.97794207
67Orthostatic hypotension (HP:0001278)1.97747629
68Biconcave vertebral bodies (HP:0004586)1.97710634
69Shoulder girdle muscle weakness (HP:0003547)1.97041527
70Broad thumb (HP:0011304)1.94860799
71Supernumerary bones of the axial skeleton (HP:0009144)1.94825635
72Anal stenosis (HP:0002025)1.94082220
73Slow saccadic eye movements (HP:0000514)1.93576151
74Prominent nose (HP:0000448)1.93390899
75Broad distal phalanx of finger (HP:0009836)1.92620130
76Proximal placement of thumb (HP:0009623)1.91808959
77Neoplasm of striated muscle (HP:0009728)1.90896113
78Short phalanx of the thumb (HP:0009660)1.89993625
79Bladder diverticulum (HP:0000015)1.89498797
80Spina bifida occulta (HP:0003298)1.88343671
81Broad palm (HP:0001169)1.87462972
82Abnormal large intestine physiology (HP:0012700)1.87257217
83Turricephaly (HP:0000262)1.86944005
84Deep palmar crease (HP:0006191)1.86633269
85Sacral dimple (HP:0000960)1.86583775
86Neuronal loss in central nervous system (HP:0002529)1.86562920
87Lower limb amyotrophy (HP:0007210)1.86387803
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86133978
89Difficulty running (HP:0009046)1.85840266
90Basal cell carcinoma (HP:0002671)1.84916952
91Gastrointestinal carcinoma (HP:0002672)1.84891064
92Malignant gastrointestinal tract tumors (HP:0006749)1.84891064
93Patellar dislocation (HP:0002999)1.84519934
94Urethral obstruction (HP:0000796)1.83927902
95Enlarged penis (HP:0000040)1.83067488
96Apathy (HP:0000741)1.82573482
97Decreased motor nerve conduction velocity (HP:0003431)1.81804665
98Abnormality of the columella (HP:0009929)1.81434857
99Deviation of the thumb (HP:0009603)1.80836220
100Skull defect (HP:0001362)1.80761346
101Multiple enchondromatosis (HP:0005701)1.79921671
102Calcaneovalgus deformity (HP:0001848)1.79353954
103Cutis marmorata (HP:0000965)1.79251188
104Thin ribs (HP:0000883)1.78241735
105Arnold-Chiari malformation (HP:0002308)1.78068692
106Megalocornea (HP:0000485)1.77886670
107Selective tooth agenesis (HP:0001592)1.77117176
108Sandal gap (HP:0001852)1.76306416
109Broad face (HP:0000283)1.75866228
110Metaphyseal cupping (HP:0003021)1.75002805
111Precocious puberty (HP:0000826)1.74731128
112Abnormal number of incisors (HP:0011064)1.74288422
113Increased connective tissue (HP:0009025)1.73950921
114Preauricular skin tag (HP:0000384)1.73671395
115Dislocated radial head (HP:0003083)1.72037372
116Medulloblastoma (HP:0002885)1.70927686
117Lymphangioma (HP:0100764)1.70926001
118Abnormality of the musculature of the pelvis (HP:0001469)1.70015673
119Abnormality of the hip-girdle musculature (HP:0001445)1.70015673
120Dysautonomia (HP:0002459)1.68695345
121Fibroma (HP:0010614)1.68568170
122Uterine leiomyosarcoma (HP:0002891)1.67992889
123Leiomyosarcoma (HP:0100243)1.67992889
124Shawl scrotum (HP:0000049)1.67503462
125Thoracic kyphosis (HP:0002942)1.67109220
126Pelvic girdle muscle weakness (HP:0003749)1.66523740
127Overlapping toe (HP:0001845)1.66486035
128Abnormality of the Achilles tendon (HP:0005109)1.66254676
129Fibrous tissue neoplasm (HP:0012316)1.66120884
130Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66117208
131Deviation of the hallux (HP:0010051)1.66078934
132Personality changes (HP:0000751)1.65886432
133Hallux valgus (HP:0001822)1.65515277
134Abnormality of oral frenula (HP:0000190)1.65475372
135Breech presentation (HP:0001623)1.65451152
136Abnormality of the thoracic spine (HP:0100711)1.64692522
137Genu recurvatum (HP:0002816)1.63375135
138Rectal prolapse (HP:0002035)1.63176984
139High pitched voice (HP:0001620)1.63047417
140Difficulty climbing stairs (HP:0003551)1.62521472
141Mitral valve prolapse (HP:0001634)1.61958257
142Progressive hearing impairment (HP:0001730)1.61170369
143Hypopigmentation of the fundus (HP:0007894)1.60897677
144Long palpebral fissure (HP:0000637)1.60679870
145Diminished motivation (HP:0000745)1.60448368
146Short 1st metacarpal (HP:0010034)1.60407781
147Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.60407781
148Microvesicular hepatic steatosis (HP:0001414)1.60033182
149Hemiplegia (HP:0002301)1.59756894
150Abnormality of the radial head (HP:0003995)1.59581349
151Abnormality of chromosome segregation (HP:0002916)1.59507549
152Nonimmune hydrops fetalis (HP:0001790)1.59060943
153Oligodactyly (HP:0012165)1.58953296
154Attention deficit hyperactivity disorder (HP:0007018)1.58718586
155EMG: neuropathic changes (HP:0003445)1.58659435
156Narrow palate (HP:0000189)1.58321287
157Vertebral fusion (HP:0002948)1.57397807
158Upper motor neuron abnormality (HP:0002127)1.57236728
159Eczematoid dermatitis (HP:0000976)1.57033709
160Protrusio acetabuli (HP:0003179)1.57021615
161Broad phalanges of the hand (HP:0009768)1.56977765
162Abnormality of the distal phalanx of the thumb (HP:0009617)1.56670850
163Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56168310
164Ankle clonus (HP:0011448)1.56093385
165Fatigue (HP:0012378)1.55885501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.37753133
2MAP3K104.27847085
3TRIB33.69035355
4SMG13.68614973
5EEF2K3.20726728
6PRPF4B3.06774211
7PKN22.91745627
8ICK2.48463510
9SIK22.25225526
10NEK22.20264039
11BRD41.96713868
12CDC71.96142981
13TYRO31.95393781
14RIPK11.88938872
15ALK1.83122272
16SRPK11.81457506
17PDGFRA1.77000065
18LATS11.76151313
19MAP3K131.65697694
20PTK61.65076975
21SIK11.63179932
22MTOR1.53204800
23NEK11.48624892
24LATS21.45558587
25RPS6KA41.43850832
26ERN11.42888016
27TAOK11.41557458
28CAMK1G1.38761766
29TTN1.37689001
30MAP3K141.28944831
31CDK41.28597169
32SIK31.25113029
33CAMK1D1.16492956
34BMX1.16413485
35MAP3K91.09114594
36PAK61.08778205
37PRKD31.07355047
38TESK21.07288713
39KSR21.06970720
40IRAK31.05791509
41RPS6KB21.05780136
42TAOK21.02759147
43STK101.00405232
44PAK40.99158231
45STK380.97061195
46CDK60.96740678
47GRK60.96651102
48MAP4K10.95837881
49PRKD20.95641053
50MAP3K70.95607283
51CDC42BPA0.95490759
52ARAF0.95231431
53MKNK10.93280996
54TTK0.93003264
55DDR20.92090866
56DMPK0.90876464
57CHEK10.90858350
58NTRK10.90734875
59RIPK40.90638244
60PDGFRB0.88928119
61MARK20.87801274
62MAP3K110.86673400
63FGR0.84114477
64UHMK10.83386282
65FGFR40.80954958
66CLK10.80190320
67KSR10.79943118
68MAP2K20.79933106
69FGFR10.78772142
70PRKCH0.77388815
71LRRK20.76553436
72CDK20.75227894
73MAP3K80.74791393
74PTK20.74076993
75MAPK110.73728548
76PAK20.71814229
77CDK11A0.70728482
78DYRK1B0.70009221
79MOS0.69888395
80SCYL20.68014511
81TSSK60.67887841
82NME20.66936268
83CDK70.66838301
84FGFR30.66468472
85MAP3K10.64533212
86PNCK0.64530630
87CDK150.62928186
88ATR0.62411608
89YES10.62325291
90PASK0.62150640
91CDK180.61096684
92AKT20.59789686
93FGFR20.58876011
94NTRK20.58819521
95CSNK1E0.58670591
96LMTK20.58600776
97EPHA20.58104335
98HIPK20.57666749
99RET0.57276161
100IRAK40.56953730
101CDK140.54133172
102FES0.54132891
103CSF1R0.54071230
104STK110.53857368
105STK30.53703871
106CSNK1D0.53258282
107ATM0.53160029
108EPHB10.53113817
109BRAF0.52408168
110CDK10.51704459
111RPS6KC10.51308594
112RPS6KL10.51308594
113PRKDC0.50728585
114PRKD10.49107275
115ERBB20.47973697
116RPS6KA20.47909429
117KDR0.47907720
118GSK3B0.46919622
119RAF10.46767213
120RPS6KA10.46267251
121MAPK100.45940412
122MAPK140.45188697
123CAMKK10.44606661
124TBK10.44358785
125CHEK20.44030775
126MAP2K30.43021814
127MAPK80.41828959
128BCR0.41499438
129CAMK40.41435051
130WNK10.41428972
131MAPK90.39638733
132PLK10.39637204
133CSK0.39447339
134CDK90.38565258
135STK40.38262790
136PRKAA10.38199307
137AURKA0.37806055
138JAK30.36104194
139HCK0.35591320
140MAP3K60.35188406
141DYRK30.33784647
142PAK30.33747958
143PHKG20.33320551
144PHKG10.33320551

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.59273241
2Lysine degradation_Homo sapiens_hsa003102.28978370
3Notch signaling pathway_Homo sapiens_hsa043302.16267236
4mTOR signaling pathway_Homo sapiens_hsa041502.02153454
5mRNA surveillance pathway_Homo sapiens_hsa030152.01061416
6Chronic myeloid leukemia_Homo sapiens_hsa052201.76329158
7Basal cell carcinoma_Homo sapiens_hsa052171.75590127
8Spliceosome_Homo sapiens_hsa030401.72797474
9Thyroid hormone signaling pathway_Homo sapiens_hsa049191.63204405
10Dorso-ventral axis formation_Homo sapiens_hsa043201.53049933
11MicroRNAs in cancer_Homo sapiens_hsa052061.47083719
12Non-small cell lung cancer_Homo sapiens_hsa052231.45088928
13Pentose phosphate pathway_Homo sapiens_hsa000301.44513295
14Endometrial cancer_Homo sapiens_hsa052131.39583478
15Type II diabetes mellitus_Homo sapiens_hsa049301.38920380
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.38185074
17Nitrogen metabolism_Homo sapiens_hsa009101.38119928
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.37528276
19Hippo signaling pathway_Homo sapiens_hsa043901.33844606
20Hedgehog signaling pathway_Homo sapiens_hsa043401.33810543
21RNA transport_Homo sapiens_hsa030131.33415141
22Colorectal cancer_Homo sapiens_hsa052101.31533429
23Fructose and mannose metabolism_Homo sapiens_hsa000511.29315447
24Herpes simplex infection_Homo sapiens_hsa051681.28841801
25Glioma_Homo sapiens_hsa052141.26726426
26VEGF signaling pathway_Homo sapiens_hsa043701.26140359
27Proteoglycans in cancer_Homo sapiens_hsa052051.26080422
28Adherens junction_Homo sapiens_hsa045201.25605202
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24867103
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.22350529
31Estrogen signaling pathway_Homo sapiens_hsa049151.21424958
32Shigellosis_Homo sapiens_hsa051311.19079481
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.17007273
34Prion diseases_Homo sapiens_hsa050201.16364970
35Bladder cancer_Homo sapiens_hsa052191.15692009
36Hepatitis B_Homo sapiens_hsa051611.15635826
37Apoptosis_Homo sapiens_hsa042101.14113728
38Acute myeloid leukemia_Homo sapiens_hsa052211.14106306
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13666553
40Small cell lung cancer_Homo sapiens_hsa052221.12704465
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12617241
42Insulin resistance_Homo sapiens_hsa049311.11516192
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10517552
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09823413
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07676504
46Epstein-Barr virus infection_Homo sapiens_hsa051691.06934831
47Renal cell carcinoma_Homo sapiens_hsa052111.06934722
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05671963
49HTLV-I infection_Homo sapiens_hsa051661.03836344
50Cell cycle_Homo sapiens_hsa041101.03157701
51Oocyte meiosis_Homo sapiens_hsa041141.02688116
52B cell receptor signaling pathway_Homo sapiens_hsa046621.01165121
53Insulin signaling pathway_Homo sapiens_hsa049101.00929933
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00331372
55Other glycan degradation_Homo sapiens_hsa005111.00115345
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00085801
57Wnt signaling pathway_Homo sapiens_hsa043100.98485886
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98082144
59AMPK signaling pathway_Homo sapiens_hsa041520.96448678
60Viral myocarditis_Homo sapiens_hsa054160.96395989
61Non-homologous end-joining_Homo sapiens_hsa034500.96214188
62ErbB signaling pathway_Homo sapiens_hsa040120.95626451
63Dilated cardiomyopathy_Homo sapiens_hsa054140.94987462
64Focal adhesion_Homo sapiens_hsa045100.93941480
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92980573
66Pancreatic cancer_Homo sapiens_hsa052120.91396915
67Glucagon signaling pathway_Homo sapiens_hsa049220.91104238
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88626009
69Salmonella infection_Homo sapiens_hsa051320.88166152
70Thyroid cancer_Homo sapiens_hsa052160.88045621
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87919883
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86787158
73Osteoclast differentiation_Homo sapiens_hsa043800.86739827
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.86411218
75Tight junction_Homo sapiens_hsa045300.85950489
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85635496
77Long-term potentiation_Homo sapiens_hsa047200.85556119
78Melanogenesis_Homo sapiens_hsa049160.85337027
79Mismatch repair_Homo sapiens_hsa034300.85122541
80T cell receptor signaling pathway_Homo sapiens_hsa046600.84286074
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83453574
82Carbon metabolism_Homo sapiens_hsa012000.82656980
83GnRH signaling pathway_Homo sapiens_hsa049120.82642698
84Influenza A_Homo sapiens_hsa051640.82457152
85Hepatitis C_Homo sapiens_hsa051600.79718054
86Choline metabolism in cancer_Homo sapiens_hsa052310.78577600
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.78137144
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78080350
89Measles_Homo sapiens_hsa051620.77592243
90Pathways in cancer_Homo sapiens_hsa052000.77312013
91Rap1 signaling pathway_Homo sapiens_hsa040150.76020686
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75657950
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75553318
94Viral carcinogenesis_Homo sapiens_hsa052030.75380494
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74345523
96Axon guidance_Homo sapiens_hsa043600.73663249
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73594805
98Prolactin signaling pathway_Homo sapiens_hsa049170.73352705
99Gap junction_Homo sapiens_hsa045400.72931983
100Prostate cancer_Homo sapiens_hsa052150.72925488
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72350317
102Oxytocin signaling pathway_Homo sapiens_hsa049210.72064863
103MAPK signaling pathway_Homo sapiens_hsa040100.71750943
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71575497
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70991991
106FoxO signaling pathway_Homo sapiens_hsa040680.70982641
107Galactose metabolism_Homo sapiens_hsa000520.69725228
108Leishmaniasis_Homo sapiens_hsa051400.67213630
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67179082
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66677357
111Biosynthesis of amino acids_Homo sapiens_hsa012300.65119760
112Base excision repair_Homo sapiens_hsa034100.64857126
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.64159572
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63943274
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63915789
116HIF-1 signaling pathway_Homo sapiens_hsa040660.63808209
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61990427
118Primary immunodeficiency_Homo sapiens_hsa053400.61399816
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.60995849
120Gastric acid secretion_Homo sapiens_hsa049710.60326865
121Toxoplasmosis_Homo sapiens_hsa051450.59914656
122Insulin secretion_Homo sapiens_hsa049110.59542192
123Tuberculosis_Homo sapiens_hsa051520.58397540
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.58017674
125Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56844385
126Fatty acid biosynthesis_Homo sapiens_hsa000610.55395754
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55321142
128Legionellosis_Homo sapiens_hsa051340.55206815
129Antigen processing and presentation_Homo sapiens_hsa046120.54163199
130Endocytosis_Homo sapiens_hsa041440.54156859
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53896399
132One carbon pool by folate_Homo sapiens_hsa006700.53881722
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53276607
134TNF signaling pathway_Homo sapiens_hsa046680.53037455
135DNA replication_Homo sapiens_hsa030300.51967784
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50532040
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50280681
138Platelet activation_Homo sapiens_hsa046110.50018208

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