SAFB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.17655696
2regulation of gamma-delta T cell differentiation (GO:0045586)4.82678239
3positive regulation of histone deacetylation (GO:0031065)4.65260083
4regulation of gamma-delta T cell activation (GO:0046643)4.48418494
5positive thymic T cell selection (GO:0045059)4.40679757
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.26998409
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26998409
8negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.19697213
9antigen processing and presentation of endogenous antigen (GO:0019883)4.18503320
10negative regulation of cell killing (GO:0031342)4.11236778
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.11236778
12cellular extravasation (GO:0045123)3.83557897
13histone H3-K4 trimethylation (GO:0080182)3.79319571
14histone H3-K4 methylation (GO:0051568)3.78666339
15thymic T cell selection (GO:0045061)3.51189260
16regulation of ARF protein signal transduction (GO:0032012)3.44554086
17regulation of interleukin-12 biosynthetic process (GO:0045075)3.42989603
18negative regulation of histone methylation (GO:0031061)3.38315401
19positive regulation of CREB transcription factor activity (GO:0032793)3.38289691
20pre-miRNA processing (GO:0031054)3.29844088
21mannose metabolic process (GO:0006013)3.28954626
22positive T cell selection (GO:0043368)3.25924869
23N-acetylneuraminate metabolic process (GO:0006054)3.25625556
24RNA stabilization (GO:0043489)3.25551757
25mRNA stabilization (GO:0048255)3.25551757
26negative regulation of erythrocyte differentiation (GO:0045647)3.23934925
27positive regulation of protein deacetylation (GO:0090312)3.22962730
28positive regulation of B cell differentiation (GO:0045579)3.22925153
29B cell receptor signaling pathway (GO:0050853)3.22169786
30negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21675729
31positive regulation of gene expression, epigenetic (GO:0045815)3.18461805
32microglial cell activation (GO:0001774)3.15910493
33negative thymic T cell selection (GO:0045060)3.15527735
34peptidyl-lysine dimethylation (GO:0018027)3.14237353
35positive regulation by symbiont of host defense response (GO:0052509)3.13926585
36modulation by symbiont of host defense response (GO:0052031)3.13926585
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13926585
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13926585
39positive regulation by organism of defense response of other organism involved in symbiotic interact3.13926585
40modulation by symbiont of host immune response (GO:0052553)3.13926585
41cytoplasmic mRNA processing body assembly (GO:0033962)3.13620227
42T cell selection (GO:0045058)3.11868771
43positive regulation of granulocyte differentiation (GO:0030854)3.08598199
44antigen processing and presentation via MHC class Ib (GO:0002475)3.07835461
45negative regulation of histone acetylation (GO:0035067)3.07079800
46negative T cell selection (GO:0043383)3.05044330
47regulation of histone H3-K27 methylation (GO:0061085)3.02632608
48histone H3 deacetylation (GO:0070932)3.02409466
49regulation of B cell differentiation (GO:0045577)3.01919707
50peptidyl-lysine trimethylation (GO:0018023)3.00975969
51mucosal-associated lymphoid tissue development (GO:0048537)3.00068095
52Peyers patch development (GO:0048541)3.00068095
53negative regulation of granulocyte differentiation (GO:0030853)2.93032899
54positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.89375130
55signal complex assembly (GO:0007172)2.89063568
56regulation of Rap GTPase activity (GO:0032317)2.88274295
57histone lysine methylation (GO:0034968)2.88155724
58intracellular estrogen receptor signaling pathway (GO:0030520)2.87513756
59positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86560557
60response to muramyl dipeptide (GO:0032495)2.85060105
61regulation of B cell receptor signaling pathway (GO:0050855)2.84036960
62negative regulation of lymphocyte mediated immunity (GO:0002707)2.83430682
63JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.82762270
64spliceosomal tri-snRNP complex assembly (GO:0000244)2.82466584
65negative regulation of toll-like receptor signaling pathway (GO:0034122)2.80107356
66negative regulation of T cell mediated immunity (GO:0002710)2.79934464
67histone H3-K36 demethylation (GO:0070544)2.79331760
68negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.78988542
69negative regulation of mRNA metabolic process (GO:1903312)2.78198522
70regulation of cholesterol homeostasis (GO:2000188)2.78123598
71synaptic vesicle maturation (GO:0016188)2.77533106
72chromatin silencing (GO:0006342)2.77130384
73positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.75619052
74negative regulation of RNA splicing (GO:0033119)2.75245209
75macrophage activation involved in immune response (GO:0002281)2.75007364
76negative regulation of interleukin-12 production (GO:0032695)2.74627445
77negative regulation of mRNA processing (GO:0050686)2.73331837
78regulation of nucleobase-containing compound transport (GO:0032239)2.73120734
79negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72810515
80negative regulation of translation, ncRNA-mediated (GO:0040033)2.72810515
81regulation of translation, ncRNA-mediated (GO:0045974)2.72810515
82negative regulation of gene expression, epigenetic (GO:0045814)2.72747685
83neutrophil mediated immunity (GO:0002446)2.70597615
84histone H4 deacetylation (GO:0070933)2.68952943
85peptidyl-lysine methylation (GO:0018022)2.67133921
86negative regulation of leukocyte mediated immunity (GO:0002704)2.65812690
87NIK/NF-kappaB signaling (GO:0038061)2.65010121
88histone H3-K9 methylation (GO:0051567)2.63715880
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62876699
90leukocyte aggregation (GO:0070486)2.61891109
91histone H4-K16 acetylation (GO:0043984)2.60917630
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.60890326
93negative regulation of peptidyl-lysine acetylation (GO:2000757)2.60403095
94histone demethylation (GO:0016577)2.60083339
95negative regulation of stress fiber assembly (GO:0051497)2.60060470
963-UTR-mediated mRNA stabilization (GO:0070935)2.59998339
97activation of JUN kinase activity (GO:0007257)2.59630202
98regulation of RNA export from nucleus (GO:0046831)2.59182326
99macrophage activation (GO:0042116)2.59049634
100heterochromatin organization (GO:0070828)2.57831506
101negative regulation of cAMP-mediated signaling (GO:0043951)2.57258816
102histone lysine demethylation (GO:0070076)2.55212386
103regulation of interferon-beta biosynthetic process (GO:0045357)2.55157748
104negative regulation of myotube differentiation (GO:0010832)2.54452904
105regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53163796
106dosage compensation (GO:0007549)2.53054474
107positive regulation of Rap GTPase activity (GO:0032854)2.51832248
108mitotic G1 DNA damage checkpoint (GO:0031571)2.50472517
109modulation by virus of host process (GO:0019054)2.50217650
110response to peptidoglycan (GO:0032494)2.49568842
111regulation of histone deacetylation (GO:0031063)2.49242837
112positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48844299
113natural killer cell differentiation (GO:0001779)2.47672629
114insulin-like growth factor receptor signaling pathway (GO:0048009)2.47268428
115interferon-gamma production (GO:0032609)2.46556612
116regulation of ARF GTPase activity (GO:0032312)2.43182271
117regulation of defense response to virus by virus (GO:0050690)2.42426375
118protein dealkylation (GO:0008214)2.40972059
119protein demethylation (GO:0006482)2.40972059
120regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.40932568
121negative regulation of histone modification (GO:0031057)2.40844089
122activation of Rac GTPase activity (GO:0032863)2.40688877
123negative regulation of bone resorption (GO:0045779)2.39934584
124germinal center formation (GO:0002467)2.38611611
125histone H4-K12 acetylation (GO:0043983)2.36667491
126positive regulation of RNA splicing (GO:0033120)2.35336502
127regulation of histone H3-K9 methylation (GO:0051570)2.35334241
128regulation of translational fidelity (GO:0006450)2.33676160
129histone methylation (GO:0016571)2.33234599
130adaptation of signaling pathway (GO:0023058)2.32097769
131regulation of mRNA stability (GO:0043488)2.31635119
132endothelial cell chemotaxis (GO:0035767)2.31513376
133modulation by symbiont of host cellular process (GO:0044068)2.30617588
134histone H3-K9 modification (GO:0061647)2.30022234
135megakaryocyte development (GO:0035855)2.29387395
136histone H3-K9 demethylation (GO:0033169)2.28933274
137response to laminar fluid shear stress (GO:0034616)2.26484533
138mitotic G1/S transition checkpoint (GO:0044819)2.26147555
139glucocorticoid receptor signaling pathway (GO:0042921)2.26114104
140response to interleukin-15 (GO:0070672)2.25994939
141regulation of erythrocyte differentiation (GO:0045646)2.25965700
142regulation of histone H3-K4 methylation (GO:0051569)2.25964443
143regulation of integrin activation (GO:0033623)2.25564166
144regulation of granulocyte differentiation (GO:0030852)2.24489658
145tolerance induction (GO:0002507)2.23604575
146mature B cell differentiation (GO:0002335)2.22713882
147regulation of RNA stability (GO:0043487)2.21938307
148maternal placenta development (GO:0001893)2.21280621
149regulation of chromatin binding (GO:0035561)2.21076196
150regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.21035597
151apoptotic cell clearance (GO:0043277)2.20753229
152trophectodermal cell differentiation (GO:0001829)2.17768081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.06506985
2E2F7_22180533_ChIP-Seq_HELA_Human3.60007739
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.51175402
4VDR_21846776_ChIP-Seq_THP-1_Human3.34867998
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.20333258
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06363616
7TCF7_22412390_ChIP-Seq_EML_Mouse2.81336948
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.71503528
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.61669767
10KDM2B_26808549_Chip-Seq_DND41_Human2.49874992
11KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.42233115
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.39710994
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.34426908
14SCL_19346495_ChIP-Seq_HPC-7_Human2.30330750
15MAF_26560356_Chip-Seq_TH1_Human2.29530659
16UTX_26944678_Chip-Seq_JUKART_Human2.18403483
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14454168
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12732774
19VDR_24763502_ChIP-Seq_THP-1_Human1.99654590
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.96544688
21DROSHA_22980978_ChIP-Seq_HELA_Human1.89567668
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89453105
23LXR_22292898_ChIP-Seq_THP-1_Human1.88925422
24CIITA_25753668_ChIP-Seq_RAJI_Human1.87655877
25MYB_26560356_Chip-Seq_TH1_Human1.86635707
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.86341808
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85822268
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85485914
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82229664
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78977773
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77403589
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74218904
33SPI1_23127762_ChIP-Seq_K562_Human1.72656523
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68699766
35MYB_26560356_Chip-Seq_TH2_Human1.65806290
36SMC4_20622854_ChIP-Seq_HELA_Human1.65318611
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64584578
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64527551
39MAF_26560356_Chip-Seq_TH2_Human1.61267279
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.61134096
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.60851177
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56745170
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.55480866
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54534372
45NCOR1_26117541_ChIP-Seq_K562_Human1.54256911
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.49677713
47RUNX_20019798_ChIP-Seq_JUKART_Human1.48870166
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48626984
49* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47550401
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45010286
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41800487
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40401092
53RACK7_27058665_Chip-Seq_MCF-7_Human1.40384480
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39360809
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38871692
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38801893
57STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38003234
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.37939774
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37928445
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36572394
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33497397
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32125091
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.31734855
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30323261
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29776880
66OCT4_19829295_ChIP-Seq_ESCs_Human1.29499401
67* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.29273421
68KDM2B_26808549_Chip-Seq_K562_Human1.28245776
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27338754
70* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27193559
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.26941067
72BCL6_27268052_Chip-Seq_Bcells_Human1.26712655
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25405384
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23901920
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.23676241
76* SPI1_23547873_ChIP-Seq_NB4_Human1.20814543
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20689861
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19128275
79P68_20966046_ChIP-Seq_HELA_Human1.18177574
80RXR_22158963_ChIP-Seq_LIVER_Mouse1.16032886
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15503027
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14080233
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13492955
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12633030
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12471694
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10705164
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09953586
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07344419
89GATA1_19941826_ChIP-Seq_K562_Human1.07186060
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07051196
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06378971
92* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05754835
93PHF8_20622854_ChIP-Seq_HELA_Human1.04303991
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03709447
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03455645
96PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02945397
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.02901367
98SA1_27219007_Chip-Seq_Bcells_Human1.02738278
99CREB1_26743006_Chip-Seq_LNCaP_Human1.02072968
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01621128
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01210246
102RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01133672
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00869598
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00346127
105GATA6_25053715_ChIP-Seq_YYC3_Human1.00343848
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00061087
107GATA1_22025678_ChIP-Seq_K562_Human0.99116111
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98188856
109FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97829401
110CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97169280
111* E2F1_20622854_ChIP-Seq_HELA_Human0.97131786
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97107907
113KDM5A_27292631_Chip-Seq_BREAST_Human0.96423331
114* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95887190
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95543182
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95513248
117RUNX1_27514584_Chip-Seq_MCF-7_Human0.95273786
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95272289
119LXR_22158963_ChIP-Seq_LIVER_Mouse0.94967349
120BCOR_27268052_Chip-Seq_Bcells_Human0.94345704
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94309749
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94136187
123SA1_27219007_Chip-Seq_ERYTHROID_Human0.93800418
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93582709
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.92552957
126PU_27001747_Chip-Seq_BMDM_Mouse0.92488103
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92316847
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92167059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.08623707
2MP0004859_abnormal_synaptic_plasticity2.90457903
3MP0003300_gastrointestinal_ulcer2.88941507
4MP0000569_abnormal_digit_pigmentation2.80993284
5MP0003303_peritoneal_inflammation2.74324517
6MP0000685_abnormal_immune_system2.72815210
7MP0001800_abnormal_humoral_immune2.50111166
8MP0002396_abnormal_hematopoietic_system2.44714376
9MP0005076_abnormal_cell_differentiation2.38900184
10MP0001835_abnormal_antigen_presentation2.38725995
11MP0005387_immune_system_phenotype2.34542371
12MP0001790_abnormal_immune_system2.34542371
13MP0005451_abnormal_body_composition2.34492280
14MP0003787_abnormal_imprinting2.28110823
15MP0008961_abnormal_basal_metabolism2.17420665
16MP0003763_abnormal_thymus_physiology2.14299059
17MP0004808_abnormal_hematopoietic_stem2.04274672
18MP0002398_abnormal_bone_marrow1.97491149
19MP0002452_abnormal_antigen_presenting1.97344418
20MP0003436_decreased_susceptibility_to1.93505520
21MP0008260_abnormal_autophagy1.92469536
22MP0003705_abnormal_hypodermis_morpholog1.91575384
23MP0005397_hematopoietic_system_phenotyp1.89121695
24MP0001545_abnormal_hematopoietic_system1.89121695
25MP0003172_abnormal_lysosome_physiology1.87862764
26MP0001873_stomach_inflammation1.87166659
27MP0002166_altered_tumor_susceptibility1.86884631
28MP0003690_abnormal_glial_cell1.86612744
29MP0002723_abnormal_immune_serum1.82082308
30MP0003329_amyloid_beta_deposits1.79813012
31MP0001502_abnormal_circadian_rhythm1.78736274
32MP0002420_abnormal_adaptive_immunity1.75568719
33MP0001819_abnormal_immune_cell1.72952647
34MP0004510_myositis1.72927767
35MP0010352_gastrointestinal_tract_polyps1.68352662
36MP0000689_abnormal_spleen_morphology1.67810140
37MP0000716_abnormal_immune_system1.66492114
38MP0005000_abnormal_immune_tolerance1.64905561
39MP0000703_abnormal_thymus_morphology1.64577955
40MP0002722_abnormal_immune_system1.64223967
41MP0005464_abnormal_platelet_physiology1.63790155
42MP0004947_skin_inflammation1.63529711
43MP0005670_abnormal_white_adipose1.59570279
44MP0005671_abnormal_response_to1.56524899
45MP0003111_abnormal_nucleus_morphology1.54729303
46MP0002405_respiratory_system_inflammati1.52856430
47MP0010155_abnormal_intestine_physiology1.51557797
48MP0005174_abnormal_tail_pigmentation1.50426247
49MP0005025_abnormal_response_to1.50274871
50MP0002429_abnormal_blood_cell1.45529232
51MP0009840_abnormal_foam_cell1.45465145
52MP0003866_abnormal_defecation1.41768446
53MP0002419_abnormal_innate_immunity1.41335757
54MP0002009_preneoplasia1.39131212
55MP0010307_abnormal_tumor_latency1.38237789
56MP0008057_abnormal_DNA_replication1.36155453
57MP0002006_tumorigenesis1.34844536
58MP0002064_seizures1.33736105
59MP0003724_increased_susceptibility_to1.31184504
60MP0000604_amyloidosis1.31009879
61MP0003566_abnormal_cell_adhesion1.30483103
62MP0003635_abnormal_synaptic_transmissio1.26248205
63MP0003656_abnormal_erythrocyte_physiolo1.25080628
64MP0001853_heart_inflammation1.23473086
65MP0002928_abnormal_bile_duct1.23113391
66MP0003045_fibrosis1.22714970
67MP0003191_abnormal_cellular_cholesterol1.21485922
68MP0004264_abnormal_extraembryonic_tissu1.20618214
69MP0009333_abnormal_splenocyte_physiolog1.17052958
70MP0002063_abnormal_learning/memory/cond1.14947759
71MP0001501_abnormal_sleep_pattern1.14232819
72MP0001845_abnormal_inflammatory_respons1.14011073
73MP0005365_abnormal_bile_salt1.11582949
74MP0001533_abnormal_skeleton_physiology1.11202475
75MP0005310_abnormal_salivary_gland1.11167260
76MP0008569_lethality_at_weaning1.10005341
77MP0003077_abnormal_cell_cycle1.09865780
78MP0000371_diluted_coat_color1.08632369
79MP0009115_abnormal_fat_cell1.08212994
80MP0006082_CNS_inflammation1.07335171
81MP0000609_abnormal_liver_physiology1.06093531
82MP0003252_abnormal_bile_duct1.06037580
83MP0005083_abnormal_biliary_tract1.05778776
84MP0004185_abnormal_adipocyte_glucose1.05614252
85MP0004381_abnormal_hair_follicle1.05591749
86MP0000003_abnormal_adipose_tissue1.03489774
87MP0000490_abnormal_crypts_of1.02237888
88MP0002019_abnormal_tumor_incidence1.01959624
89MP0004043_abnormal_pH_regulation1.01698905
90MP0001348_abnormal_lacrimal_gland1.00545595
91MP0004742_abnormal_vestibular_system0.99674112
92MP0005666_abnormal_adipose_tissue0.99346451
93MP0004130_abnormal_muscle_cell0.98672862
94MP0003183_abnormal_peptide_metabolism0.98114198
95MP0000350_abnormal_cell_proliferation0.97889804
96MP0001849_ear_inflammation0.96465440
97MP0010094_abnormal_chromosome_stability0.95892933
98MP0002970_abnormal_white_adipose0.92133910
99MP0003693_abnormal_embryo_hatching0.91242454
100MP0005023_abnormal_wound_healing0.90996197
101MP0002254_reproductive_system_inflammat0.90377446
102MP0010630_abnormal_cardiac_muscle0.90087886
103MP0003453_abnormal_keratinocyte_physiol0.90080906
104MP0005375_adipose_tissue_phenotype0.89838127
105MP0002877_abnormal_melanocyte_morpholog0.89261674
106MP0002148_abnormal_hypersensitivity_rea0.89010970
107MP0004197_abnormal_fetal_growth/weight/0.87630662
108MP0000465_gastrointestinal_hemorrhage0.85886691
109MP0000313_abnormal_cell_death0.85173867
110MP0000733_abnormal_muscle_development0.82448491
111MP0002086_abnormal_extraembryonic_tissu0.81691150
112MP0005058_abnormal_lysosome_morphology0.81314621
113MP0003984_embryonic_growth_retardation0.81283397
114MP0001915_intracranial_hemorrhage0.80918231
115MP0002088_abnormal_embryonic_growth/wei0.80614295
116MP0008469_abnormal_protein_level0.80161735
117MP0009672_abnormal_birth_weight0.79785153
118MP0000598_abnormal_liver_morphology0.79364499
119MP0001672_abnormal_embryogenesis/_devel0.79017929
120MP0005380_embryogenesis_phenotype0.79017929
121MP0000858_altered_metastatic_potential0.78290725
122MP0003828_pulmonary_edema0.78123646
123MP0009785_altered_susceptibility_to0.77739805
124MP0003879_abnormal_hair_cell0.77145851
125MP0003448_altered_tumor_morphology0.76177008
126MP0001851_eye_inflammation0.75968753
127MP0003091_abnormal_cell_migration0.75758349
128MP0000920_abnormal_myelination0.73878223
129MP0008874_decreased_physiological_sensi0.73552229
130MP0000678_abnormal_parathyroid_gland0.73339230
131MP0008007_abnormal_cellular_replicative0.73203789
132MP0003075_altered_response_to0.72858456
133MP0002925_abnormal_cardiovascular_devel0.71954473
134MP0004811_abnormal_neuron_physiology0.70911538
135MP0005621_abnormal_cell_physiology0.69366990
136MP0002998_abnormal_bone_remodeling0.69057892
137MP0003634_abnormal_glial_cell0.68266743
138MP0001986_abnormal_taste_sensitivity0.64618263
139MP0005334_abnormal_fat_pad0.63650333
140MP0003880_abnormal_central_pattern0.63407098
141MP0002971_abnormal_brown_adipose0.63282066
142MP0002572_abnormal_emotion/affect_behav0.62932444
143MP0001663_abnormal_digestive_system0.62797867
144MP0005423_abnormal_somatic_nervous0.62280765
145MP0000015_abnormal_ear_pigmentation0.61624164
146MP0008877_abnormal_DNA_methylation0.61120285
147MP0009745_abnormal_behavioral_response0.60538130

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.78779058
2Abnormality of the fingertips (HP:0001211)4.70776997
3Papilledema (HP:0001085)3.92457275
4Hyperacusis (HP:0010780)3.39656048
5Colitis (HP:0002583)3.27234704
6Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.18334474
7Cerebral aneurysm (HP:0004944)3.08873699
8Abnormal delayed hypersensitivity skin test (HP:0002963)3.06793230
9Gastrointestinal inflammation (HP:0004386)3.04042094
10Recurrent fungal infections (HP:0002841)3.02833911
11Inflammation of the large intestine (HP:0002037)3.02431680
12Recurrent viral infections (HP:0004429)2.99525155
13Deep palmar crease (HP:0006191)2.84452704
14Cellulitis (HP:0100658)2.81813222
15Peripheral hypomyelination (HP:0007182)2.80814233
16Agammaglobulinemia (HP:0004432)2.78902613
17Dysmetric saccades (HP:0000641)2.74533463
18Autoimmune thrombocytopenia (HP:0001973)2.73902971
19Eczematoid dermatitis (HP:0000976)2.72658250
20Pustule (HP:0200039)2.71748848
21Abnormality of binocular vision (HP:0011514)2.71018097
22Diplopia (HP:0000651)2.71018097
23Visual hallucinations (HP:0002367)2.67122670
24Macroorchidism (HP:0000053)2.66131828
25Chronic obstructive pulmonary disease (HP:0006510)2.57219866
26Obstructive lung disease (HP:0006536)2.57219866
27Chronic mucocutaneous candidiasis (HP:0002728)2.55144300
28Recurrent cutaneous fungal infections (HP:0011370)2.55144300
29Increased cerebral lipofuscin (HP:0011813)2.54098782
30Slow saccadic eye movements (HP:0000514)2.53098243
31Neuronal loss in central nervous system (HP:0002529)2.52407747
32Panhypogammaglobulinemia (HP:0003139)2.50059169
33Urethral obstruction (HP:0000796)2.46876962
34Long eyelashes (HP:0000527)2.44742517
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.43186028
36Genetic anticipation (HP:0003743)2.42811772
37Ulnar bowing (HP:0003031)2.40050835
38Nasal polyposis (HP:0100582)2.39821225
39Recurrent bronchitis (HP:0002837)2.37224120
40Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33993421
41Elfin facies (HP:0004428)2.33213493
42Ankle clonus (HP:0011448)2.32063146
43T lymphocytopenia (HP:0005403)2.31015602
44Emphysema (HP:0002097)2.28520766
45Global brain atrophy (HP:0002283)2.27873960
46Annular pancreas (HP:0001734)2.22471381
47Periodontitis (HP:0000704)2.22212524
48Chronic otitis media (HP:0000389)2.21572860
49Orchitis (HP:0100796)2.21244964
50Prominent nose (HP:0000448)2.20350527
51Papilloma (HP:0012740)2.20324811
52Verrucae (HP:0200043)2.20324811
53Recurrent bacterial skin infections (HP:0005406)2.16174574
54Abnormality of the nasal mucosa (HP:0000433)2.16140253
55Clumsiness (HP:0002312)2.15588781
56Renovascular hypertension (HP:0100817)2.15396217
57Stomatitis (HP:0010280)2.15049973
58Supranuclear gaze palsy (HP:0000605)2.14438111
59Abnormality of T cell number (HP:0011839)2.14279650
60Recurrent abscess formation (HP:0002722)2.13945606
61IgM deficiency (HP:0002850)2.13393722
62Pseudobulbar signs (HP:0002200)2.11797227
63Mediastinal lymphadenopathy (HP:0100721)2.11728561
64Truncal obesity (HP:0001956)2.11216549
65Anal stenosis (HP:0002025)2.11131770
66Depressed nasal tip (HP:0000437)2.11089168
67Abnormality of T cells (HP:0002843)2.10586465
68Prolonged bleeding time (HP:0003010)2.09698845
69Myocardial infarction (HP:0001658)2.08822771
70Optic neuritis (HP:0100653)2.08542762
71Retrobulbar optic neuritis (HP:0100654)2.08542762
72Meningitis (HP:0001287)2.08148360
73Heterotopia (HP:0002282)2.05923083
74Spontaneous hematomas (HP:0007420)2.05051093
75Hemiplegia (HP:0002301)2.04200222
76Abnormality of the columella (HP:0009929)2.02200137
77Gastrointestinal infarctions (HP:0005244)2.01645681
78Cerebral inclusion bodies (HP:0100314)2.01621677
79Gastrointestinal stroma tumor (HP:0100723)2.01363757
80Hematochezia (HP:0002573)2.01207033
81Hand muscle atrophy (HP:0009130)2.00630969
82Protruding tongue (HP:0010808)2.00467247
83Abnormality of T cell physiology (HP:0011840)1.98829301
84Upper limb amyotrophy (HP:0009129)1.98041581
85Distal upper limb amyotrophy (HP:0007149)1.98041581
86Recurrent gram-negative bacterial infections (HP:0005420)1.97490548
87Vertebral arch anomaly (HP:0008438)1.96979138
88Supernumerary bones of the axial skeleton (HP:0009144)1.96256516
89Gingival bleeding (HP:0000225)1.96200747
90Increased IgE level (HP:0003212)1.94152277
91Elevated erythrocyte sedimentation rate (HP:0003565)1.91840725
92Impaired platelet aggregation (HP:0003540)1.90968111
93Abnormal platelet function (HP:0011869)1.90968111
94Chest pain (HP:0100749)1.89193040
95Aneurysm (HP:0002617)1.88997330
96Stereotypic behavior (HP:0000733)1.88469128
97Tented upper lip vermilion (HP:0010804)1.88359131
98Ependymoma (HP:0002888)1.88060515
99Centrally nucleated skeletal muscle fibers (HP:0003687)1.88016293
100Truncal ataxia (HP:0002078)1.87342781
101Skin tags (HP:0010609)1.87313974
102Acute lymphatic leukemia (HP:0006721)1.86563449
103Sleep apnea (HP:0010535)1.86268130
104Basal cell carcinoma (HP:0002671)1.86165267
105Intestinal fistula (HP:0100819)1.85894894
106Supernumerary ribs (HP:0005815)1.85782271
107Neurofibrillary tangles (HP:0002185)1.85667910
108IgA deficiency (HP:0002720)1.85393797
109Abnormality of cells of the lymphoid lineage (HP:0012140)1.85019193
110Recurrent skin infections (HP:0001581)1.84920611
111Epistaxis (HP:0000421)1.83608883
112Viral hepatitis (HP:0006562)1.83374968
113Segmental peripheral demyelination/remyelination (HP:0003481)1.82615899
114Dislocated radial head (HP:0003083)1.82129574
115Lymphopenia (HP:0001888)1.81604385
116Abnormality of the thoracic spine (HP:0100711)1.80046764
117Subacute progressive viral hepatitis (HP:0006572)1.78785570
118Polygenic inheritance (HP:0010982)1.77557551
119Postural instability (HP:0002172)1.77407673
120Broad face (HP:0000283)1.77382751
121Increased nuchal translucency (HP:0010880)1.77345268
122Insomnia (HP:0100785)1.76944310
123Onion bulb formation (HP:0003383)1.76744182
124Sporadic (HP:0003745)1.76675202
125Hypercortisolism (HP:0001578)1.76143600
126Aplasia/Hypoplasia of the thymus (HP:0010515)1.75366481
127Epileptic encephalopathy (HP:0200134)1.75137243
128Abnormality of the endocardium (HP:0004306)1.74286740
129Narrow palate (HP:0000189)1.73920933
130Gingivitis (HP:0000230)1.73867981
131Hyperthyroidism (HP:0000836)1.72887456
132Hemoptysis (HP:0002105)1.72265610
133Arterial thrombosis (HP:0004420)1.71898875
134Cutis marmorata (HP:0000965)1.71731690
135Progressive microcephaly (HP:0000253)1.71158122
136Disproportionate tall stature (HP:0001519)1.70374769
137Spastic gait (HP:0002064)1.70301635
138Abnormality of B cell number (HP:0010975)1.69855443
139B lymphocytopenia (HP:0010976)1.69855443
140Vasculitis (HP:0002633)1.68959950
141Lip pit (HP:0100267)1.67551470
142Thoracic kyphosis (HP:0002942)1.65126999
143Renal duplication (HP:0000075)1.65032665
144Osteomyelitis (HP:0002754)1.64409265
145Thyroiditis (HP:0100646)1.62767957
146Cheilitis (HP:0100825)1.62533782
147Thrombocytosis (HP:0001894)1.61758683
148Restrictive lung disease (HP:0002091)1.61650014
149Obsessive-compulsive behavior (HP:0000722)1.61462557
150Abnormality of the lower motor neuron (HP:0002366)1.61374525
151Hypochromic anemia (HP:0001931)1.61279602
152Broad palm (HP:0001169)1.61167324
153Reticulocytosis (HP:0001923)1.60545626
154Poikiloderma (HP:0001029)1.59492482
155Leukocytosis (HP:0001974)1.58475446
156Volvulus (HP:0002580)1.57835049
157Pointed chin (HP:0000307)1.56927641
158Myositis (HP:0100614)1.55763778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.88900255
2MAP4K13.67219953
3MAP3K103.47551694
4SMG13.02451614
5ERN12.75543997
6TRIB32.71657870
7PRPF4B2.65529919
8EEF2K2.52642043
9SIK22.37846426
10PKN22.32655081
11BRD42.07218837
12TAOK31.92930868
13RIPK11.87946927
14CAMK1G1.87515753
15SIK11.81443997
16CAMK1D1.78808809
17TYK21.68926261
18PTK61.61276382
19ICK1.60458851
20FGFR41.53679260
21STK101.48777647
22BLK1.47559502
23MAP3K111.41198634
24NEK21.41017168
25CAMKK11.40156289
26JAK31.37990864
27GRK61.37492480
28JAK11.36551955
29SIK31.30980368
30ALK1.28529076
31MAP3K71.26352968
32BTK1.25673125
33ZAP701.24486895
34CSF1R1.24414029
35EPHB11.22006219
36MTOR1.19089323
37MAP3K131.18493949
38TAOK11.18481608
39MAP3K91.18052205
40NTRK31.17540848
41KIT1.16485976
42CDK41.16368716
43PRKD21.14197469
44IRAK31.13991349
45TGFBR21.13762942
46CSK1.12878322
47TTN1.10116944
48MAP3K141.08028411
49HCK1.06835626
50BMX1.06561944
51CHUK1.05468078
52TBK11.04794792
53CDK61.03592317
54IKBKE1.03404778
55HIPK20.96728444
56MAP2K30.95902240
57IKBKB0.93409082
58UHMK10.92182480
59CAMKK20.89771984
60CCNB10.88361903
61FGFR30.87922111
62KSR20.85875554
63SYK0.85302493
64ITK0.84774277
65JAK20.83083773
66FLT30.82475883
67PAK60.81229559
68LRRK20.80563348
69MAP2K20.80376108
70CDC42BPA0.79659479
71MARK20.79540672
72CLK10.76802933
73MARK30.76398159
74TXK0.75976351
75RIPK40.75089436
76MAPK110.75058445
77RPS6KA40.74579935
78PIM10.74577007
79MAPK100.74207745
80MAP3K10.73997299
81MAPK120.73917134
82DYRK1B0.73544138
83PRKCH0.73529889
84DAPK20.72134766
85PDK10.71762687
86LCK0.70740966
87LATS10.70006984
88FES0.68608594
89PDPK10.67661140
90CAMK10.67282824
91DMPK0.66853956
92NTRK20.65515858
93STK40.64391582
94MAPK150.64291805
95FGR0.64189847
96RPS6KB20.64152183
97PRKD30.63522152
98ATR0.62820641
99IRAK40.62592658
100CAMK40.61368410
101PDGFRA0.60773910
102SGK30.57751863
103PDGFRB0.56837727
104TNK20.55220134
105DYRK1A0.54648674
106CDK70.54061976
107CDC70.51831219
108CDK90.51357536
109STK380.50834983
110STK110.50202376
111MAPK70.49967001
112SGK10.49489602
113LYN0.49338898
114RPS6KA20.47825708
115PRKAA20.47745993
116MKNK20.47340195
117MAP2K60.45969632
118CHEK10.45164869
119MAPK80.45143997
120MAP3K80.44465881
121PRKD10.44462142
122PAK40.44322195
123SGK20.44108802
124TEC0.43921444
125CDK20.43694599
126RPS6KA60.43027117
127MAPK40.41786014
128MARK10.41018067
129RPS6KC10.40837091
130RPS6KL10.40837091
131PAK20.39911964
132TYRO30.38924031
133RPS6KA10.38282675

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.80231615
2Primary immunodeficiency_Homo sapiens_hsa053402.70247102
3B cell receptor signaling pathway_Homo sapiens_hsa046622.68661279
4Osteoclast differentiation_Homo sapiens_hsa043801.90737172
5Chronic myeloid leukemia_Homo sapiens_hsa052201.84624458
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.84519061
7Acute myeloid leukemia_Homo sapiens_hsa052211.77881740
8Notch signaling pathway_Homo sapiens_hsa043301.73225212
9Leishmaniasis_Homo sapiens_hsa051401.64303716
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58395443
11T cell receptor signaling pathway_Homo sapiens_hsa046601.45839285
12Caffeine metabolism_Homo sapiens_hsa002321.43095707
13Herpes simplex infection_Homo sapiens_hsa051681.40280844
14Measles_Homo sapiens_hsa051621.40192476
15Long-term potentiation_Homo sapiens_hsa047201.36117670
16mTOR signaling pathway_Homo sapiens_hsa041501.34124528
17Insulin resistance_Homo sapiens_hsa049311.33239756
18Type II diabetes mellitus_Homo sapiens_hsa049301.31735346
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31674628
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28503745
21Staphylococcus aureus infection_Homo sapiens_hsa051501.25936928
22Antigen processing and presentation_Homo sapiens_hsa046121.25881505
23Non-small cell lung cancer_Homo sapiens_hsa052231.24436225
24Renal cell carcinoma_Homo sapiens_hsa052111.23334694
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20596654
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20410857
27Small cell lung cancer_Homo sapiens_hsa052221.19978645
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.19626598
29GnRH signaling pathway_Homo sapiens_hsa049121.18705053
30Toxoplasmosis_Homo sapiens_hsa051451.18246168
31Synaptic vesicle cycle_Homo sapiens_hsa047211.17634455
32ErbB signaling pathway_Homo sapiens_hsa040121.17327089
33Influenza A_Homo sapiens_hsa051641.15513846
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.14840098
35Allograft rejection_Homo sapiens_hsa053301.14044739
36ABC transporters_Homo sapiens_hsa020101.13830205
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13734717
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.13201451
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13029687
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12995965
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11286298
42Chemokine signaling pathway_Homo sapiens_hsa040621.07394211
43Pancreatic cancer_Homo sapiens_hsa052121.06520432
44Hepatitis B_Homo sapiens_hsa051611.06091064
45Hematopoietic cell lineage_Homo sapiens_hsa046401.06036157
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.05802097
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05324747
48Nitrogen metabolism_Homo sapiens_hsa009101.03599390
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02238303
50Apoptosis_Homo sapiens_hsa042101.01611636
51Autoimmune thyroid disease_Homo sapiens_hsa053200.98039382
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97858675
53HTLV-I infection_Homo sapiens_hsa051660.97474159
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97058349
55mRNA surveillance pathway_Homo sapiens_hsa030150.96700018
56TNF signaling pathway_Homo sapiens_hsa046680.96585791
57Graft-versus-host disease_Homo sapiens_hsa053320.95106227
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93347539
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93213577
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93115913
61MicroRNAs in cancer_Homo sapiens_hsa052060.92146462
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.91827953
63One carbon pool by folate_Homo sapiens_hsa006700.91344143
64Prolactin signaling pathway_Homo sapiens_hsa049170.90943453
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90844098
66Platelet activation_Homo sapiens_hsa046110.90737424
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.89865378
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.89149358
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88227151
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88037346
71VEGF signaling pathway_Homo sapiens_hsa043700.87691984
72Tuberculosis_Homo sapiens_hsa051520.87630046
73Type I diabetes mellitus_Homo sapiens_hsa049400.86344842
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81638712
75Prion diseases_Homo sapiens_hsa050200.81527484
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81431831
77Cholinergic synapse_Homo sapiens_hsa047250.79476703
78Viral myocarditis_Homo sapiens_hsa054160.77923453
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77642863
80Proteoglycans in cancer_Homo sapiens_hsa052050.76388237
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.75615428
82Endometrial cancer_Homo sapiens_hsa052130.72405318
83Insulin secretion_Homo sapiens_hsa049110.71460883
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70177002
85Other glycan degradation_Homo sapiens_hsa005110.69571465
86Oxytocin signaling pathway_Homo sapiens_hsa049210.68211440
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68100469
88Endocytosis_Homo sapiens_hsa041440.68065744
89Asthma_Homo sapiens_hsa053100.67364402
90Insulin signaling pathway_Homo sapiens_hsa049100.67318688
91Gastric acid secretion_Homo sapiens_hsa049710.66882306
92Legionellosis_Homo sapiens_hsa051340.65354202
93Inositol phosphate metabolism_Homo sapiens_hsa005620.65101648
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64925388
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.64316028
96Hepatitis C_Homo sapiens_hsa051600.63535492
97HIF-1 signaling pathway_Homo sapiens_hsa040660.63143274
98Selenocompound metabolism_Homo sapiens_hsa004500.62843322
99Viral carcinogenesis_Homo sapiens_hsa052030.61916507
100Prostate cancer_Homo sapiens_hsa052150.61873178
101Colorectal cancer_Homo sapiens_hsa052100.60469924
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59911691
103FoxO signaling pathway_Homo sapiens_hsa040680.59709380
104cAMP signaling pathway_Homo sapiens_hsa040240.59373206
105AMPK signaling pathway_Homo sapiens_hsa041520.58326266
106Spliceosome_Homo sapiens_hsa030400.58227288
107Base excision repair_Homo sapiens_hsa034100.57698935
108Glioma_Homo sapiens_hsa052140.57579689
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.57525342
110Bladder cancer_Homo sapiens_hsa052190.54952968
111Arginine biosynthesis_Homo sapiens_hsa002200.51754745
112Adherens junction_Homo sapiens_hsa045200.51456986
113Dorso-ventral axis formation_Homo sapiens_hsa043200.51229590
114Shigellosis_Homo sapiens_hsa051310.51026987
115Choline metabolism in cancer_Homo sapiens_hsa052310.50861728
116Estrogen signaling pathway_Homo sapiens_hsa049150.49921183
117Glucagon signaling pathway_Homo sapiens_hsa049220.48319647
118Epstein-Barr virus infection_Homo sapiens_hsa051690.48143686
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48116527
120MAPK signaling pathway_Homo sapiens_hsa040100.47479449
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46366569
122Bile secretion_Homo sapiens_hsa049760.46106059
123Pathways in cancer_Homo sapiens_hsa052000.46009341
124Complement and coagulation cascades_Homo sapiens_hsa046100.44228449
125Pertussis_Homo sapiens_hsa051330.42310319
126Focal adhesion_Homo sapiens_hsa045100.41808857

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