SAG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* detection of visible light (GO:0009584)9.91728119
2positive regulation of guanylate cyclase activity (GO:0031284)9.23328256
3* visual perception (GO:0007601)9.06227108
4* sensory perception of light stimulus (GO:0050953)8.95817424
5protein-chromophore linkage (GO:0018298)8.94242313
6regulation of guanylate cyclase activity (GO:0031282)8.34500902
7photoreceptor cell differentiation (GO:0046530)8.07065933
8eye photoreceptor cell differentiation (GO:0001754)8.07065933
9* cellular response to light stimulus (GO:0071482)7.28075524
10retina development in camera-type eye (GO:0060041)7.21755273
11* detection of external stimulus (GO:0009581)7.05138006
12* detection of abiotic stimulus (GO:0009582)6.92197533
13regulation of cGMP metabolic process (GO:0030823)6.19070563
14behavioral response to nicotine (GO:0035095)5.97009277
15positive regulation of cGMP biosynthetic process (GO:0030828)5.41479784
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.40461948
17nonmotile primary cilium assembly (GO:0035058)5.19274652
18regulation of cGMP biosynthetic process (GO:0030826)5.08410205
19positive regulation of cGMP metabolic process (GO:0030825)4.78118555
20cell morphogenesis involved in neuron differentiation (GO:0048667)4.73330335
21* cellular response to radiation (GO:0071478)4.71998414
22receptor guanylyl cyclase signaling pathway (GO:0007168)4.62479349
23adaptation of signaling pathway (GO:0023058)4.59963383
24detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.48380198
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.34988174
26* sensory perception (GO:0007600)4.26405827
27regulation of clathrin-mediated endocytosis (GO:2000369)4.25977526
28protein prenylation (GO:0018342)4.19464560
29prenylation (GO:0097354)4.19464560
30tryptophan catabolic process (GO:0006569)4.16467216
31indole-containing compound catabolic process (GO:0042436)4.16467216
32indolalkylamine catabolic process (GO:0046218)4.16467216
33retina layer formation (GO:0010842)4.13786124
34fucose catabolic process (GO:0019317)4.12914470
35L-fucose metabolic process (GO:0042354)4.12914470
36L-fucose catabolic process (GO:0042355)4.12914470
37kynurenine metabolic process (GO:0070189)4.10504093
38estrogen biosynthetic process (GO:0006703)4.10407856
39* regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.07305416
40regulation of voltage-gated calcium channel activity (GO:1901385)3.96034515
41indolalkylamine metabolic process (GO:0006586)3.91985129
42neuron development (GO:0048666)3.91679390
43* response to light stimulus (GO:0009416)3.87932157
44DNA deamination (GO:0045006)3.84754529
45retina homeostasis (GO:0001895)3.83557224
46peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.73852436
47water-soluble vitamin biosynthetic process (GO:0042364)3.56553068
48negative regulation of receptor-mediated endocytosis (GO:0048261)3.53706344
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.46632118
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.45742069
51sulfation (GO:0051923)3.43752834
52gamma-aminobutyric acid transport (GO:0015812)3.43076780
53protein localization to synapse (GO:0035418)3.42023813
54tryptophan metabolic process (GO:0006568)3.41935264
55short-term memory (GO:0007614)3.41719549
56regulation of short-term neuronal synaptic plasticity (GO:0048172)3.38038224
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.32746381
58indole-containing compound metabolic process (GO:0042430)3.26324464
59cellular ketone body metabolic process (GO:0046950)3.23015216
60behavioral response to ethanol (GO:0048149)3.16142708
61positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.14355793
62regulation of penile erection (GO:0060405)3.14326815
63cornea development in camera-type eye (GO:0061303)3.12829743
64axoneme assembly (GO:0035082)3.12285089
65positive regulation of neurotransmitter transport (GO:0051590)3.10055822
66positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.08840358
67cell proliferation in forebrain (GO:0021846)3.06938354
68chemosensory behavior (GO:0007635)3.06858215
69primary amino compound metabolic process (GO:1901160)3.06411588
70membrane hyperpolarization (GO:0060081)3.05614068
71regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.05244689
72regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.05244689
73negative regulation of mast cell activation (GO:0033004)3.03073312
74retinoid metabolic process (GO:0001523)3.00359831
75serotonin metabolic process (GO:0042428)3.00261955
76mitochondrial respiratory chain complex I assembly (GO:0032981)3.00222326
77NADH dehydrogenase complex assembly (GO:0010257)3.00222326
78mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00222326
79transmission of nerve impulse (GO:0019226)3.00048758
80protein polyglutamylation (GO:0018095)2.98229639
81CDP-diacylglycerol biosynthetic process (GO:0016024)2.98094538
82epithelial cilium movement (GO:0003351)2.98003996
83neuronal action potential (GO:0019228)2.96999807
84positive regulation of sodium ion transmembrane transport (GO:1902307)2.95906324
85negative regulation of telomere maintenance (GO:0032205)2.95340532
86kidney morphogenesis (GO:0060993)2.95279924
87ketone body metabolic process (GO:1902224)2.93829572
88piRNA metabolic process (GO:0034587)2.91946968
89amine catabolic process (GO:0009310)2.90017366
90cellular biogenic amine catabolic process (GO:0042402)2.90017366
91somite development (GO:0061053)2.88954246
92protein complex biogenesis (GO:0070271)2.88237946
93protein heterotetramerization (GO:0051290)2.86393381
94regulation of mesoderm development (GO:2000380)2.84688212
95response to histamine (GO:0034776)2.84674221
96membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83720789
97platelet dense granule organization (GO:0060155)2.82597888
98parturition (GO:0007567)2.81521827
99regulation of action potential (GO:0098900)2.80639787
100neural tube formation (GO:0001841)2.80068010
101phosphatidylinositol acyl-chain remodeling (GO:0036149)2.77869994
102diterpenoid metabolic process (GO:0016101)2.77787596
103regulation of gene silencing by RNA (GO:0060966)2.76368302
104regulation of posttranscriptional gene silencing (GO:0060147)2.76368302
105regulation of gene silencing by miRNA (GO:0060964)2.76368302
106negative regulation of transcription regulatory region DNA binding (GO:2000678)2.75577726
107synaptic vesicle maturation (GO:0016188)2.74785073
108multicellular organism reproduction (GO:0032504)2.73931464
109regulation of hippo signaling (GO:0035330)2.73508108
110retinol metabolic process (GO:0042572)2.72008765
111CDP-diacylglycerol metabolic process (GO:0046341)2.71377071
112lipid translocation (GO:0034204)2.69108701
113phospholipid translocation (GO:0045332)2.69108701
114* response to radiation (GO:0009314)2.69032797
115cellular response to ATP (GO:0071318)2.67581285
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.67125919
117reflex (GO:0060004)2.66911711
118arachidonic acid secretion (GO:0050482)2.62088845
119icosanoid secretion (GO:0032309)2.62088845
120positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.61206875
121male meiosis I (GO:0007141)2.58542709
122mitochondrial respiratory chain complex assembly (GO:0033108)2.58521365
123positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.56613204
124post-embryonic morphogenesis (GO:0009886)2.56542780
125detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.56200916
126cilium movement (GO:0003341)2.55466500
127response to pheromone (GO:0019236)2.55026211
128lipoprotein transport (GO:0042953)2.54031706
129terpenoid metabolic process (GO:0006721)2.53975035
130synaptic vesicle docking involved in exocytosis (GO:0016081)2.53888236
131cilium or flagellum-dependent cell motility (GO:0001539)2.53474773
132synaptic transmission, cholinergic (GO:0007271)2.53286938
133negative regulation of systemic arterial blood pressure (GO:0003085)2.53233990
134negative regulation of cation channel activity (GO:2001258)2.52849668
135DNA methylation involved in gamete generation (GO:0043046)2.52024664
136regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.50517645
137negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.49869236
138negative regulation of calcium ion transmembrane transport (GO:1903170)2.49123982
139negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.49123982
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48555567
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48555567
142negative regulation of cytosolic calcium ion concentration (GO:0051481)2.47646719
143dopamine receptor signaling pathway (GO:0007212)2.46269723
144protein-cofactor linkage (GO:0018065)2.45836273
145cilium organization (GO:0044782)2.45788872
146spinal cord motor neuron differentiation (GO:0021522)2.45651887
147positive regulation of fatty acid transport (GO:2000193)2.44598746
148rRNA catabolic process (GO:0016075)2.43206359
149negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42125243
150negative regulation of translation, ncRNA-mediated (GO:0040033)2.42125243
151regulation of translation, ncRNA-mediated (GO:0045974)2.42125243
152reciprocal DNA recombination (GO:0035825)2.42064950
153reciprocal meiotic recombination (GO:0007131)2.42064950
154positive regulation of oligodendrocyte differentiation (GO:0048714)2.40554970
155endoderm formation (GO:0001706)2.40382627
156nephron tubule morphogenesis (GO:0072078)2.40324328
157nephron epithelium morphogenesis (GO:0072088)2.40324328
158positive regulation of ERBB signaling pathway (GO:1901186)2.40313365
159replication fork processing (GO:0031297)2.40260399
160peristalsis (GO:0030432)2.40056533
161preassembly of GPI anchor in ER membrane (GO:0016254)2.39738112
162dopamine transport (GO:0015872)2.39566883
163oxidative demethylation (GO:0070989)2.38442316
164opioid receptor signaling pathway (GO:0038003)2.38001954
165righting reflex (GO:0060013)2.37773904
166detection of chemical stimulus involved in sensory perception (GO:0050907)2.37649925
167regulation of neurotransmitter uptake (GO:0051580)2.36278984
168NAD biosynthetic process (GO:0009435)2.36127441
169* cellular response to abiotic stimulus (GO:0071214)2.32931493
170positive regulation of membrane potential (GO:0045838)2.27200813
171synaptic transmission, dopaminergic (GO:0001963)2.26450435
172behavioral response to cocaine (GO:0048148)2.26426932
173cellular potassium ion homeostasis (GO:0030007)2.23909644
174* regulation of rhodopsin mediated signaling pathway (GO:0022400)17.7927295
175* rhodopsin mediated signaling pathway (GO:0016056)17.4015238
176retinal cone cell development (GO:0046549)15.1459177
177photoreceptor cell development (GO:0042461)13.2061661
178photoreceptor cell maintenance (GO:0045494)12.9001329
179eye photoreceptor cell development (GO:0042462)12.5351771
180detection of light stimulus involved in sensory perception (GO:0050962)11.0554276
181detection of light stimulus involved in visual perception (GO:0050908)11.0554276
182retinal rod cell development (GO:0046548)10.9935172
183GMP metabolic process (GO:0046037)10.8121140
184* phototransduction (GO:0007602)10.6662024
185* phototransduction, visible light (GO:0007603)10.3838067
186* detection of light stimulus (GO:0009583)10.1135563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.76899641
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.74956686
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.89741085
4EZH2_22144423_ChIP-Seq_EOC_Human3.79071465
5ZNF274_21170338_ChIP-Seq_K562_Hela3.71246770
6VDR_22108803_ChIP-Seq_LS180_Human3.25553363
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.84664490
8GBX2_23144817_ChIP-Seq_PC3_Human2.84657015
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.73498187
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57338694
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42506245
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22184679
13DROSHA_22980978_ChIP-Seq_HELA_Human2.20904743
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05594704
15EWS_26573619_Chip-Seq_HEK293_Human2.03407619
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.98608290
17FUS_26573619_Chip-Seq_HEK293_Human1.98452046
18TAF15_26573619_Chip-Seq_HEK293_Human1.87464421
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83492461
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82779223
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76399766
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75857201
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.75532988
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.74581010
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74563045
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71902493
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71250733
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69449635
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67047143
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66236979
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66226739
32IRF1_19129219_ChIP-ChIP_H3396_Human1.65659970
33IGF1R_20145208_ChIP-Seq_DFB_Human1.65409432
34P53_22127205_ChIP-Seq_FIBROBLAST_Human1.62650289
35* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.61539579
36REST_21632747_ChIP-Seq_MESCs_Mouse1.58971716
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57916932
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56906356
39AR_21572438_ChIP-Seq_LNCaP_Human1.56150429
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55973357
41* SMAD3_21741376_ChIP-Seq_HESCs_Human1.55307624
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53977604
43KDM2B_26808549_Chip-Seq_K562_Human1.52656983
44* REST_18959480_ChIP-ChIP_MESCs_Mouse1.51622420
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.50726095
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49150701
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48614689
48TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.48470198
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.47933269
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47519471
51TP53_22573176_ChIP-Seq_HFKS_Human1.46783901
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46242251
53TBL1_22424771_ChIP-Seq_293T_Human1.44461850
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44457500
55* AR_19668381_ChIP-Seq_PC3_Human1.43854062
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.43064669
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42780721
58AR_25329375_ChIP-Seq_VCAP_Human1.41187154
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.41108873
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41017172
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41017172
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40956601
63CBP_20019798_ChIP-Seq_JUKART_Human1.40211480
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40211480
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40129371
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40027813
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40027813
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38468840
69SMAD4_21799915_ChIP-Seq_A2780_Human1.38447021
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37903402
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36807288
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.36519371
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35860984
74CTCF_27219007_Chip-Seq_Bcells_Human1.34143436
75RNF2_27304074_Chip-Seq_NSC_Mouse1.33349395
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.32733494
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32327190
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.32327190
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30146777
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.29699587
81SMC4_20622854_ChIP-Seq_HELA_Human1.28862119
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.28599089
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28158436
84EZH2_27304074_Chip-Seq_ESCs_Mouse1.28085562
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.27949378
86NANOG_19829295_ChIP-Seq_ESCs_Human1.26500724
87SOX2_19829295_ChIP-Seq_ESCs_Human1.26500724
88TAF2_19829295_ChIP-Seq_ESCs_Human1.26142115
89TCF4_22108803_ChIP-Seq_LS180_Human1.24200979
90GATA3_21878914_ChIP-Seq_MCF-7_Human1.23703691
91MYC_18940864_ChIP-ChIP_HL60_Human1.23131204
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21785595
93STAT3_23295773_ChIP-Seq_U87_Human1.21525742
94WDR5_24793694_ChIP-Seq_LNCAP_Human1.21162838
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20858848
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20543431
97RUNX2_22187159_ChIP-Seq_PCA_Human1.18859570
98SMAD4_21741376_ChIP-Seq_EPCs_Human1.17786531
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17601640
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.17141279
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17013010
102BCAT_22108803_ChIP-Seq_LS180_Human1.16474543
103* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.15652213
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14718118
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.13641596
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13301915
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13125092
108P300_19829295_ChIP-Seq_ESCs_Human1.11623907
109ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11472936
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11086898
111* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10516494
112AR_20517297_ChIP-Seq_VCAP_Human1.09565506
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09228747
114* EZH2_27294783_Chip-Seq_NPCs_Mouse1.07821176
115NCOR_22424771_ChIP-Seq_293T_Human1.07741799
116* NFE2_27457419_Chip-Seq_LIVER_Mouse1.07276652
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05982653
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05786429
119HOXB7_26014856_ChIP-Seq_BT474_Human1.05105784
120ISL1_27105846_Chip-Seq_CPCs_Mouse1.03954355
121EGR1_19032775_ChIP-ChIP_M12_Human1.03050019
122SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02957228
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02904354
124ERG_21242973_ChIP-ChIP_JURKAT_Human1.02667747
125DPY_21335234_ChIP-Seq_ESCs_Mouse1.02534001
126CBP_21632823_ChIP-Seq_H3396_Human1.02420354
127GF1_26923725_Chip-Seq_HPCs_Mouse1.00983495
128* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00786786
129JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00382456
130KDM2B_26808549_Chip-Seq_JURKAT_Human1.00037093
131OCT1_27270436_Chip-Seq_PROSTATE_Human0.99915535
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99813092
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99175738
134OCT4_19829295_ChIP-Seq_ESCs_Human0.99169524
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98858679
136TCF4_23295773_ChIP-Seq_U87_Human0.98793292
137CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98538511
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98523428
139E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97767608
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.97655030
141CREB1_26743006_Chip-Seq_LNCaP_Human0.97183933
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.97071332
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96725388
144* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95724825
145NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95522994
146P68_20966046_ChIP-Seq_HELA_Human0.95317827
147CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94921653
148SMAD4_21741376_ChIP-Seq_ESCs_Human0.94890572
149MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94731228
150SA1_27219007_Chip-Seq_Bcells_Human0.94235997
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93188554
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92858377
153ERG_20517297_ChIP-Seq_VCAP_Human0.92556692
154CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91715405
155GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90780940
156GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90426576
157* CTCF_20526341_ChIP-Seq_ESCs_Human0.90267677
158LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90024366
159ER_23166858_ChIP-Seq_MCF-7_Human0.89403479
160CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89125219
161CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87144773
162CBX2_27304074_Chip-Seq_ESCs_Mouse0.87074196
163DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85559977
164SMAD3_21741376_ChIP-Seq_ESCs_Human0.84456406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.54782047
2MP0005253_abnormal_eye_physiology6.95211641
3MP0006072_abnormal_retinal_apoptosis6.62632953
4MP0003950_abnormal_plasma_membrane3.89724323
5* MP0005195_abnormal_posterior_eye3.89330399
6MP0001324_abnormal_eye_pigmentation3.67056351
7MP0005391_vision/eye_phenotype3.42659379
8MP0002638_abnormal_pupillary_reflex3.05005472
9MP0002090_abnormal_vision2.71565223
10MP0005423_abnormal_somatic_nervous2.68180353
11MP0002229_neurodegeneration2.64854690
12MP0003195_calcinosis2.58635273
13MP0008877_abnormal_DNA_methylation2.54288028
14MP0002837_dystrophic_cardiac_calcinosis2.26640251
15MP0000569_abnormal_digit_pigmentation2.19896090
16MP0001986_abnormal_taste_sensitivity2.18016311
17MP0001764_abnormal_homeostasis2.06402966
18MP0003011_delayed_dark_adaptation11.0481288
19MP0003787_abnormal_imprinting1.94842559
20* MP0002752_abnormal_somatic_nervous1.94434881
21MP0008872_abnormal_physiological_respon1.87486047
22MP0005645_abnormal_hypothalamus_physiol1.83811248
23MP0002653_abnormal_ependyma_morphology1.79408506
24MP0002876_abnormal_thyroid_physiology1.78090529
25MP0001485_abnormal_pinna_reflex1.76441519
26MP0004147_increased_porphyrin_level1.70375348
27MP0002160_abnormal_reproductive_system1.69640827
28MP0003136_yellow_coat_color1.66503878
29MP0002736_abnormal_nociception_after1.66241011
30MP0001501_abnormal_sleep_pattern1.62796921
31MP0008875_abnormal_xenobiotic_pharmacok1.48294909
32MP0006276_abnormal_autonomic_nervous1.47929993
33MP0000427_abnormal_hair_cycle1.46181231
34MP0002938_white_spotting1.43358480
35MP0002735_abnormal_chemical_nociception1.42679242
36MP0005389_reproductive_system_phenotype1.42040722
37* MP0002882_abnormal_neuron_morphology1.37850158
38MP0002234_abnormal_pharynx_morphology1.35064742
39MP0004133_heterotaxia1.33622551
40MP0002733_abnormal_thermal_nociception1.31227767
41MP0001502_abnormal_circadian_rhythm1.30464426
42MP0001970_abnormal_pain_threshold1.27989830
43MP0004019_abnormal_vitamin_homeostasis1.27276388
44MP0006292_abnormal_olfactory_placode1.24089066
45MP0000372_irregular_coat_pigmentation1.22073834
46MP0005174_abnormal_tail_pigmentation1.17940903
47MP0005084_abnormal_gallbladder_morpholo1.17541300
48MP0002138_abnormal_hepatobiliary_system1.10929393
49MP0004885_abnormal_endolymph1.10913256
50MP0003283_abnormal_digestive_organ1.08809670
51MP0005410_abnormal_fertilization1.06907541
52MP0000383_abnormal_hair_follicle1.05530162
53MP0002163_abnormal_gland_morphology1.05430000
54MP0000049_abnormal_middle_ear1.05419899
55MP0001984_abnormal_olfaction1.05229031
56MP0005197_abnormal_uvea_morphology1.04551762
57MP0005377_hearing/vestibular/ear_phenot1.03672283
58MP0003878_abnormal_ear_physiology1.03672283
59MP0005499_abnormal_olfactory_system0.99246567
60MP0005394_taste/olfaction_phenotype0.99246567
61MP0003119_abnormal_digestive_system0.98791534
62MP0000230_abnormal_systemic_arterial0.97552169
63MP0001529_abnormal_vocalization0.96628708
64MP0004233_abnormal_muscle_weight0.95262301
65MP0001919_abnormal_reproductive_system0.94619853
66MP0004130_abnormal_muscle_cell0.92784515
67MP0001440_abnormal_grooming_behavior0.89807332
68MP0008789_abnormal_olfactory_epithelium0.89220053
69MP0002127_abnormal_cardiovascular_syste0.88753116
70MP0002095_abnormal_skin_pigmentation0.87954415
71MP0008775_abnormal_heart_ventricle0.87014743
72MP0005167_abnormal_blood-brain_barrier0.85761306
73MP0004270_analgesia0.85085759
74MP0005379_endocrine/exocrine_gland_phen0.81728379
75MP0001486_abnormal_startle_reflex0.80770261
76MP0003137_abnormal_impulse_conducting0.80053014
77MP0003698_abnormal_male_reproductive0.79479390
78MP0003718_maternal_effect0.79470641
79MP0003634_abnormal_glial_cell0.79315608
80MP0003121_genomic_imprinting0.76799452
81MP0002332_abnormal_exercise_endurance0.75464604
82MP0002277_abnormal_respiratory_mucosa0.74080838
83MP0005187_abnormal_penis_morphology0.73656138
84MP0005085_abnormal_gallbladder_physiolo0.73288285
85MP0002272_abnormal_nervous_system0.73056958
86MP0003880_abnormal_central_pattern0.71519389
87MP0001286_abnormal_eye_development0.67679644
88MP0002734_abnormal_mechanical_nocicepti0.53785456
89MP0001963_abnormal_hearing_physiology0.52575457
90MP0002064_seizures0.49209287
91MP0009046_muscle_twitch0.49072357
92MP0000465_gastrointestinal_hemorrhage0.46813418
93MP0003635_abnormal_synaptic_transmissio0.45228981
94MP0005376_homeostasis/metabolism_phenot0.41872515
95MP0004859_abnormal_synaptic_plasticity0.41568406
96MP0005248_abnormal_Harderian_gland0.41466669
97MP0002067_abnormal_sensory_capabilities0.40069609
98MP0002697_abnormal_eye_size0.37596613
99MP0004782_abnormal_surfactant_physiolog0.37528435
100MP0002102_abnormal_ear_morphology0.37150758
101MP0002063_abnormal_learning/memory/cond0.34844437
102MP0004742_abnormal_vestibular_system0.33830258
103MP0002572_abnormal_emotion/affect_behav0.33292888
104MP0000631_abnormal_neuroendocrine_gland0.32496252
105MP0004215_abnormal_myocardial_fiber0.32454472
106MP0000026_abnormal_inner_ear0.32090117
107MP0009745_abnormal_behavioral_response0.31658149
108MP0004924_abnormal_behavior0.31370424
109MP0005386_behavior/neurological_phenoty0.31370424
110MP0001968_abnormal_touch/_nociception0.30922999
111MP0003890_abnormal_embryonic-extraembry0.30459228
112MP0005193_abnormal_anterior_eye0.29862290
113MP0004142_abnormal_muscle_tone0.29344879
114MP0010386_abnormal_urinary_bladder0.28613793
115MP0004085_abnormal_heartbeat0.28153816
116MP0004145_abnormal_muscle_electrophysio0.27785938
117MP0005595_abnormal_vascular_smooth0.26001067
118MP0002152_abnormal_brain_morphology0.24440440
119MP0002184_abnormal_innervation0.24301976
120MP0001915_intracranial_hemorrhage0.24213611
121MP0005620_abnormal_muscle_contractility0.23909144
122MP0003045_fibrosis0.23129737
123MP0004043_abnormal_pH_regulation0.22778460
124MP0010030_abnormal_orbit_morphology0.22375613
125MP0008004_abnormal_stomach_pH0.22233350
126MP0008569_lethality_at_weaning0.21887639
127MP0000778_abnormal_nervous_system0.21019606
128MP0002066_abnormal_motor_capabilities/c0.20624649
129MP0008058_abnormal_DNA_repair0.19600926
130MP0001905_abnormal_dopamine_level0.18536793
131MP0004811_abnormal_neuron_physiology0.18322902
132MP0001293_anophthalmia0.17519446
133MP0003646_muscle_fatigue0.17345092
134MP0003632_abnormal_nervous_system0.16265543
135MP0001177_atelectasis0.16060563
136MP0001661_extended_life_span0.15528581
137MP0005076_abnormal_cell_differentiation0.14919401
138MP0003943_abnormal_hepatobiliary_system0.14772717
139MP0002108_abnormal_muscle_morphology0.14746909
140MP0002557_abnormal_social/conspecific_i0.14063335
141MP0005646_abnormal_pituitary_gland0.13360686
142MP0002928_abnormal_bile_duct0.13345362
143MP0003638_abnormal_response/metabolism_0.12519755
144MP0005257_abnormal_intraocular_pressure0.12244618
145MP0003633_abnormal_nervous_system0.11423839
146MP0002092_abnormal_eye_morphology0.10540677
147MP0003861_abnormal_nervous_system0.10358364
148MP0003631_nervous_system_phenotype0.09336609
149MP0009780_abnormal_chondrocyte_physiolo0.09072713
150MP0000001_mammalian_phenotype0.08957958
151MP0000955_abnormal_spinal_cord0.08653715

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.62664636
2Pendular nystagmus (HP:0012043)8.60446250
3Dyschromatopsia (HP:0007641)7.81864613
4Attenuation of retinal blood vessels (HP:0007843)7.72158611
5* Chorioretinal atrophy (HP:0000533)7.68516985
6Scotoma (HP:0000575)7.66329850
7* Pigmentary retinal degeneration (HP:0001146)7.65585802
8Abnormality of macular pigmentation (HP:0008002)7.59033455
9Abolished electroretinogram (ERG) (HP:0000550)7.54793709
10Decreased central vision (HP:0007663)6.75555719
11* Type II diabetes mellitus (HP:0005978)5.63567658
12* Photophobia (HP:0000613)5.58628628
13Keratoconus (HP:0000563)5.49577342
14Increased corneal curvature (HP:0100692)5.49577342
15Macular degeneration (HP:0000608)5.44481350
16Severe visual impairment (HP:0001141)5.39216155
17Vitreoretinal degeneration (HP:0000655)5.35789828
18Posterior subcapsular cataract (HP:0007787)5.31499642
19Cone-rod dystrophy (HP:0000548)5.13150118
20Constricted visual fields (HP:0001133)4.73132649
21Retinitis pigmentosa (HP:0000510)4.50003999
22Choroideremia (HP:0001139)4.34796444
23Progressive visual loss (HP:0000529)3.36199623
24Subcapsular cataract (HP:0000523)3.19436552
25Abnormality of the renal medulla (HP:0100957)3.09617301
26Abnormality of the renal cortex (HP:0011035)3.03078258
27Type II lissencephaly (HP:0007260)3.02080443
28Hyperventilation (HP:0002883)2.96472253
29Abnormality of alanine metabolism (HP:0010916)2.92594891
30Hyperalaninemia (HP:0003348)2.92594891
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.92594891
32Retinal atrophy (HP:0001105)2.80057134
33Abnormal drinking behavior (HP:0030082)2.67698542
34Polydipsia (HP:0001959)2.67698542
35Optic disc pallor (HP:0000543)2.66102558
36Tubular atrophy (HP:0000092)2.64483249
37Congenital sensorineural hearing impairment (HP:0008527)2.57660807
38* Wide nasal bridge (HP:0000431)2.51935078
39Absent/shortened dynein arms (HP:0200106)2.49656062
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.49656062
41Gait imbalance (HP:0002141)2.43588476
42Congenital primary aphakia (HP:0007707)2.42466415
43Gaze-evoked nystagmus (HP:0000640)2.40477570
44Inability to walk (HP:0002540)2.40409723
45Birth length less than 3rd percentile (HP:0003561)2.34126829
46Decreased circulating renin level (HP:0003351)2.28998250
47Aplasia/Hypoplasia of the patella (HP:0006498)2.20983825
48Congenital, generalized hypertrichosis (HP:0004540)2.19552795
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.19079305
50Patellar aplasia (HP:0006443)2.17161994
51Nephrogenic diabetes insipidus (HP:0009806)2.16059494
52Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14079615
53Lissencephaly (HP:0001339)2.13985271
54Polyuria (HP:0000103)2.13601533
55Clumsiness (HP:0002312)2.12785940
56Broad-based gait (HP:0002136)2.11451292
57Medial flaring of the eyebrow (HP:0010747)2.09110705
58Progressive inability to walk (HP:0002505)2.08743443
59Renal cortical cysts (HP:0000803)2.08310919
60Protruding tongue (HP:0010808)2.06720059
61Optic nerve hypoplasia (HP:0000609)2.05980501
62Abnormal respiratory motile cilium morphology (HP:0005938)2.04079426
63Abnormal respiratory epithelium morphology (HP:0012253)2.04079426
64Large for gestational age (HP:0001520)2.03933675
65Abnormal ciliary motility (HP:0012262)2.00156615
66* Congenital stationary night blindness (HP:0007642)13.3053397
67Bony spicule pigmentary retinopathy (HP:0007737)11.8596139
68Absent rod-and cone-mediated responses on ERG (HP:0007688)11.6411147
69Abnormal rod and cone electroretinograms (HP:0008323)10.9813465
70* Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99640319
71Concave nail (HP:0001598)1.99011347
72Abnormality of the pons (HP:0007361)1.91941091
73Hypoplasia of the pons (HP:0012110)1.91487798
74Acute necrotizing encephalopathy (HP:0006965)1.87920790
75True hermaphroditism (HP:0010459)1.87320350
76Bile duct proliferation (HP:0001408)1.86961133
77Abnormal biliary tract physiology (HP:0012439)1.86961133
78Poor coordination (HP:0002370)1.86396221
79Methylmalonic acidemia (HP:0002912)1.85867550
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.84748495
81Hyperglycinemia (HP:0002154)1.84463290
82Agitation (HP:0000713)1.82664937
83Aplasia/hypoplasia of the uterus (HP:0008684)1.81688561
84Mitochondrial inheritance (HP:0001427)1.79816327
85Bilateral microphthalmos (HP:0007633)1.79341023
86Hemiparesis (HP:0001269)1.77116907
87Increased CSF lactate (HP:0002490)1.76823687
88Stomach cancer (HP:0012126)1.75939252
89Polar cataract (HP:0010696)1.74823819
90Abnormality of the renal collecting system (HP:0004742)1.72818503
913-Methylglutaconic aciduria (HP:0003535)1.72767264
92Methylmalonic aciduria (HP:0012120)1.71401870
93Small hand (HP:0200055)1.70697432
94Pancreatic fibrosis (HP:0100732)1.70001386
95Abnormal urine output (HP:0012590)1.69086959
96Interstitial pulmonary disease (HP:0006530)1.68799438
97Asplenia (HP:0001746)1.68374054
98Abnormal respiratory motile cilium physiology (HP:0012261)1.68079927
99Acute encephalopathy (HP:0006846)1.66895596
100Vaginal atresia (HP:0000148)1.66857788
101Severe muscular hypotonia (HP:0006829)1.66707740
102* Optic atrophy (HP:0000648)1.63647782
103Genital tract atresia (HP:0001827)1.60311182
104Horizontal nystagmus (HP:0000666)1.53998164
105Aplasia/Hypoplasia of the lens (HP:0008063)1.43650270
106Pancreatic cysts (HP:0001737)1.41140430
107Severe Myopia (HP:0011003)1.40744739
108Cystic liver disease (HP:0006706)1.34032511
109Abnormality of the fovea (HP:0000493)1.31928533
110Aplasia/Hypoplasia of the fovea (HP:0008060)1.29183763
111Hypoplasia of the fovea (HP:0007750)1.29183763
112Sclerocornea (HP:0000647)1.20349490
113Aplasia/Hypoplasia of the tongue (HP:0010295)1.20250344
114Astigmatism (HP:0000483)1.15983491
115Dysdiadochokinesis (HP:0002075)1.15206715
116Epileptic encephalopathy (HP:0200134)1.12756039
117Retinal detachment (HP:0000541)1.11955651
118Recurrent sinusitis (HP:0011108)1.08060009
119Chorioretinal coloboma (HP:0000567)1.03978575
120Febrile seizures (HP:0002373)1.03586493
121Aplasia/Hypoplasia of the macula (HP:0008059)1.00317108
122Broad foot (HP:0001769)0.98208468
123Specific learning disability (HP:0001328)0.95650729
124Left ventricular hypertrophy (HP:0001712)0.95209314
125Hypermetropia (HP:0000540)0.92435944
126Furrowed tongue (HP:0000221)0.91847145
127Asthma (HP:0002099)0.91782128
128Decreased testicular size (HP:0008734)0.91444403
129Anencephaly (HP:0002323)0.91269406
130Aplasia/Hypoplasia affecting the retina (HP:0008061)0.90472349
131Abnormality of midbrain morphology (HP:0002418)0.85211310
132Molar tooth sign on MRI (HP:0002419)0.85211310
133Progressive cerebellar ataxia (HP:0002073)0.83697486
134Visual hallucinations (HP:0002367)0.83422788
135Congenital hepatic fibrosis (HP:0002612)0.80491703
136Cerebellar dysplasia (HP:0007033)0.79659542
137Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.79494032
138Truncal ataxia (HP:0002078)0.79445251
139Postaxial hand polydactyly (HP:0001162)0.73950325
140Abnormality of dental color (HP:0011073)0.72582606
141Postaxial foot polydactyly (HP:0001830)0.70236403
142Lymphopenia (HP:0001888)0.67837155
143Prolonged QT interval (HP:0001657)0.67823119
144Dental crowding (HP:0000678)0.67297235
145Chronic hepatic failure (HP:0100626)0.67051478
146Nephronophthisis (HP:0000090)0.66044455
147Hypodontia (HP:0000668)0.65644780
148Short foot (HP:0001773)0.64043411
149Abnormality of the fingertips (HP:0001211)0.63747153
150Anophthalmia (HP:0000528)0.63723054
151Genetic anticipation (HP:0003743)0.63390475
152Abnormality of cells of the lymphoid lineage (HP:0012140)0.61195480
153Partial agenesis of the corpus callosum (HP:0001338)0.61039301
154Aqueductal stenosis (HP:0002410)0.59820759
155Preaxial hand polydactyly (HP:0001177)0.58334885
156Male pseudohermaphroditism (HP:0000037)0.57926709
157Corneal dystrophy (HP:0001131)0.57899395
158Multicystic kidney dysplasia (HP:0000003)0.55800636

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.52539878
2ADRBK23.50146128
3IRAK23.49959429
4PINK13.34326592
5BMPR1B3.20146487
6ACVR1B3.03397775
7ZAK2.85122754
8TLK12.56288552
9MAP4K22.46471775
10WNK42.44051832
11WNK32.36482492
12MAP3K102.17925770
13NUAK12.09963444
14GRK111.0417367
15DAPK21.80690890
16TXK1.66139461
17SIK21.57044399
18CAMK1G1.52323282
19OXSR11.51503041
20ADRBK11.50183630
21BRD41.48658982
22MAPK71.48058359
23STK391.44579326
24INSRR1.44539933
25MARK11.43403784
26PNCK1.40989208
27SGK2231.35676009
28SGK4941.35676009
29CDK121.26955680
30HIPK21.25376654
31CAMK1D1.19702289
32MAPK121.19569232
33TAOK31.19537021
34ICK1.17472423
35AKT31.14999741
36TGFBR11.13544814
37ERBB21.12334072
38TIE11.12301525
39RPS6KA41.11714420
40BCKDK1.11503551
41DYRK21.10570308
42CCNB11.05683567
43STK38L1.00270609
44CSNK1D0.99997657
45SGK20.98947065
46STK380.98532405
47CAMKK20.95653079
48CDK30.95130538
49PAK30.94447274
50MAP3K40.94229793
51PAK60.92633494
52NEK10.92334587
53PRKCZ0.91414775
54PRKCH0.89142446
55NTRK30.86928218
56PRKD30.86178286
57VRK10.84930624
58MUSK0.83101143
59TNIK0.82872119
60CDK190.80951817
61PRKCE0.80216229
62SGK30.79551612
63PTK2B0.77608355
64WNK10.75437684
65MKNK20.74745855
66DYRK1A0.74102249
67TEC0.73357716
68PLK20.70471769
69CSNK1G20.70399282
70PRKCB0.69868050
71FES0.69396925
72MAPK150.67784945
73NEK20.66889454
74PLK30.66005086
75IKBKB0.65694935
76CAMK2D0.65562370
77VRK20.64695247
78PRKAA10.64054439
79MAPKAPK30.63896651
80GRK50.63271111
81NEK60.62642122
82MAP2K70.62516151
83PRKCQ0.61498785
84MAP2K60.60811943
85TTK0.60712466
86CDK90.60494370
87CSNK1G30.59180984
88CSNK1G10.58936097
89MAPKAPK50.58825396
90TNK20.57249525
91DYRK1B0.57098405
92CAMKK10.56905561
93BRSK20.56739414
94PRKACG0.56295931
95KIT0.55164198
96PRKD20.54171335
97RPS6KA30.54147270
98CSNK1A1L0.52608135
99CAMK10.52574393
100PRKAA20.50953727
101PRPF4B0.49760764
102GSK3B0.49631825
103OBSCN0.49092864
104SGK10.48040333
105PRKDC0.47814352
106GRK70.47541974
107MAPK140.47290757
108RPS6KA60.46761233
109PLK40.46402109
110CASK0.46378051
111ITK0.45689953
112PIK3CA0.45247845
113CSNK1A10.44663041
114MAPK90.43821604
115MYLK0.43810953
116SCYL20.43502355
117TAF10.43336224
118CDK10.42658384
119TRIM280.41868038
120CHUK0.41242627
121CAMK2A0.40408283
122SYK0.40311328
123EPHA40.39608049
124WEE10.39341698
125FGFR20.38999376
126CAMK40.38962189
127STK160.38057220
128LATS10.37919024
129MAPK100.37825338
130PKN10.37508545
131NME10.37504805
132AKT20.36507952
133CDK50.35272282
134STK30.34486465
135CHEK20.34038285
136PRKCG0.33306599
137CDC42BPA0.33232043
138PRKCI0.33044275
139PRKACA0.32964583
140MAP2K10.31762118
141PHKG10.31015644
142PHKG20.31015644
143ATM0.30959955
144STK110.30284356
145MINK10.30110292
146PRKCA0.26846571
147CHEK10.26746904
148RPS6KB10.25778006
149RPS6KA50.25613484
150CSNK1E0.25104722
151ALK0.25038502
152ATR0.24697211
153MAPK80.23827114
154IRAK10.23124595
155SIK10.22254418
156MAPK130.22251554
157NTRK20.22099770
158FRK0.21677649
159MKNK10.21212647
160YES10.20620365

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10454316
2Butanoate metabolism_Homo sapiens_hsa006502.07869772
3* Phototransduction_Homo sapiens_hsa0474416.0043511
4Oxidative phosphorylation_Homo sapiens_hsa001901.97685778
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91615825
6Tryptophan metabolism_Homo sapiens_hsa003801.80881366
7Homologous recombination_Homo sapiens_hsa034401.77658321
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75222566
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71204500
10Synaptic vesicle cycle_Homo sapiens_hsa047211.69410395
11RNA polymerase_Homo sapiens_hsa030201.58986455
12Selenocompound metabolism_Homo sapiens_hsa004501.57057793
13Olfactory transduction_Homo sapiens_hsa047401.54326406
14Parkinsons disease_Homo sapiens_hsa050121.44969714
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35474928
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.27063111
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26446496
18Fanconi anemia pathway_Homo sapiens_hsa034601.25787409
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.25449002
20GABAergic synapse_Homo sapiens_hsa047271.25292136
21Chemical carcinogenesis_Homo sapiens_hsa052041.24410341
22Arachidonic acid metabolism_Homo sapiens_hsa005901.24310371
23Basal transcription factors_Homo sapiens_hsa030221.21307576
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17690289
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.17233941
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09198667
27Peroxisome_Homo sapiens_hsa041461.06190234
28Propanoate metabolism_Homo sapiens_hsa006401.01845705
29Ovarian steroidogenesis_Homo sapiens_hsa049131.01534279
30Protein export_Homo sapiens_hsa030601.01455052
31Retinol metabolism_Homo sapiens_hsa008301.00317420
32One carbon pool by folate_Homo sapiens_hsa006701.00183067
33Huntingtons disease_Homo sapiens_hsa050160.99107461
34Cholinergic synapse_Homo sapiens_hsa047250.94339391
35Alzheimers disease_Homo sapiens_hsa050100.93835620
36Fat digestion and absorption_Homo sapiens_hsa049750.89401009
37Circadian rhythm_Homo sapiens_hsa047100.89021727
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88772795
39Primary immunodeficiency_Homo sapiens_hsa053400.88042472
40Sulfur relay system_Homo sapiens_hsa041220.87953231
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86250915
42Morphine addiction_Homo sapiens_hsa050320.84639430
43Glutamatergic synapse_Homo sapiens_hsa047240.83546128
44Circadian entrainment_Homo sapiens_hsa047130.83172347
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82591589
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78482655
47Dopaminergic synapse_Homo sapiens_hsa047280.77369312
48Ribosome_Homo sapiens_hsa030100.73842300
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71033254
50Asthma_Homo sapiens_hsa053100.68224349
51Serotonergic synapse_Homo sapiens_hsa047260.67353190
52beta-Alanine metabolism_Homo sapiens_hsa004100.67252954
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65467888
54Histidine metabolism_Homo sapiens_hsa003400.65418403
55Long-term depression_Homo sapiens_hsa047300.65066981
56ABC transporters_Homo sapiens_hsa020100.64614659
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64479834
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62462686
59Nitrogen metabolism_Homo sapiens_hsa009100.61909272
60Sulfur metabolism_Homo sapiens_hsa009200.60962187
61Regulation of autophagy_Homo sapiens_hsa041400.58064253
62Vitamin digestion and absorption_Homo sapiens_hsa049770.56444103
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55710078
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54893547
65Insulin secretion_Homo sapiens_hsa049110.54744785
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54684197
67Dorso-ventral axis formation_Homo sapiens_hsa043200.54491917
68Nicotine addiction_Homo sapiens_hsa050330.54491845
69Metabolic pathways_Homo sapiens_hsa011000.52874971
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52554718
71Purine metabolism_Homo sapiens_hsa002300.51128861
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47324820
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46586717
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46274356
75Hedgehog signaling pathway_Homo sapiens_hsa043400.46209755
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45721252
77Fatty acid biosynthesis_Homo sapiens_hsa000610.45276973
78Graft-versus-host disease_Homo sapiens_hsa053320.43815619
79Type I diabetes mellitus_Homo sapiens_hsa049400.41318846
80Pyrimidine metabolism_Homo sapiens_hsa002400.40044841
81Oxytocin signaling pathway_Homo sapiens_hsa049210.39895511
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.39699680
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38547631
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38085165
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36920531
86Fructose and mannose metabolism_Homo sapiens_hsa000510.35744423
87Cardiac muscle contraction_Homo sapiens_hsa042600.35647829
88cAMP signaling pathway_Homo sapiens_hsa040240.35635044
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34591612
90Inositol phosphate metabolism_Homo sapiens_hsa005620.33314609
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32717416
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31612234
93Dilated cardiomyopathy_Homo sapiens_hsa054140.30841880
94Allograft rejection_Homo sapiens_hsa053300.30788564
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30745092
96Salivary secretion_Homo sapiens_hsa049700.28918830
97mTOR signaling pathway_Homo sapiens_hsa041500.28659839
98Fatty acid elongation_Homo sapiens_hsa000620.27936513
99Renin secretion_Homo sapiens_hsa049240.26636708
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26394160
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26240446
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26187268
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25080087
104Glycerolipid metabolism_Homo sapiens_hsa005610.24986730
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.24953998
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.23803070
107Lysine degradation_Homo sapiens_hsa003100.23601872
108Gastric acid secretion_Homo sapiens_hsa049710.23592863
109mRNA surveillance pathway_Homo sapiens_hsa030150.22981184
110Alcoholism_Homo sapiens_hsa050340.22411095
111Cocaine addiction_Homo sapiens_hsa050300.22361858
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.19108420
113Chemokine signaling pathway_Homo sapiens_hsa040620.18677114
114Long-term potentiation_Homo sapiens_hsa047200.18401383
115HIF-1 signaling pathway_Homo sapiens_hsa040660.17559015
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.16253505
117Type II diabetes mellitus_Homo sapiens_hsa049300.15795271
118Glucagon signaling pathway_Homo sapiens_hsa049220.15484822
119Amphetamine addiction_Homo sapiens_hsa050310.15348947
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15048162
121Caffeine metabolism_Homo sapiens_hsa002320.14252768
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13590261
123Ras signaling pathway_Homo sapiens_hsa040140.13420133
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13341517
125Arginine biosynthesis_Homo sapiens_hsa002200.13333987
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12896807
127AMPK signaling pathway_Homo sapiens_hsa041520.12571874
128Galactose metabolism_Homo sapiens_hsa000520.12426152
129Calcium signaling pathway_Homo sapiens_hsa040200.12132131
130RNA degradation_Homo sapiens_hsa030180.11910447
131Tight junction_Homo sapiens_hsa045300.11615117
132Mineral absorption_Homo sapiens_hsa049780.10077176
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.09242521
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08994630
135GnRH signaling pathway_Homo sapiens_hsa049120.08569478
136Pancreatic secretion_Homo sapiens_hsa049720.08334370
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08111354
138Biosynthesis of amino acids_Homo sapiens_hsa012300.08061333
139Linoleic acid metabolism_Homo sapiens_hsa005910.07640616
140Collecting duct acid secretion_Homo sapiens_hsa049660.07371420
141MAPK signaling pathway_Homo sapiens_hsa040100.07255088
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07159512
143Wnt signaling pathway_Homo sapiens_hsa043100.06451042
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.06288825
145Bile secretion_Homo sapiens_hsa049760.06230676
146Thyroid hormone synthesis_Homo sapiens_hsa049180.06061538
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.06033541
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05530978
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.05202235
150Choline metabolism in cancer_Homo sapiens_hsa052310.04997647
151Taste transduction_Homo sapiens_hsa047420.04950012
152Notch signaling pathway_Homo sapiens_hsa043300.04168642
153Ether lipid metabolism_Homo sapiens_hsa005650.04067368
154Hippo signaling pathway_Homo sapiens_hsa043900.03864718
155Glioma_Homo sapiens_hsa052140.02034196
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.01083117
157Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.00842277
158Melanogenesis_Homo sapiens_hsa049160.00627832

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