SAGE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a class of genes that are activated in tumors. These genes are expressed in tumors of different histologic types but not in normal tissues, except for spermatogenic cells and, for some, placenta. The proteins encoded by these genes appear to be strictly tumor specific, and hence may be excellent sources of antigens for cancer immunotherapy. This gene is expressed in sarcomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)8.09771956
2nuclear pore organization (GO:0006999)7.02531608
3pore complex assembly (GO:0046931)6.10916441
4regulation of translational fidelity (GO:0006450)5.73583847
5DNA replication checkpoint (GO:0000076)5.61785832
6DNA unwinding involved in DNA replication (GO:0006268)5.10104313
7resolution of meiotic recombination intermediates (GO:0000712)4.80810198
8diterpenoid biosynthetic process (GO:0016102)4.78403018
9meiotic chromosome segregation (GO:0045132)4.78175802
10mitotic nuclear envelope disassembly (GO:0007077)4.70057606
11mitotic sister chromatid segregation (GO:0000070)4.66109029
12regulation of RNA export from nucleus (GO:0046831)4.65706509
13DNA topological change (GO:0006265)4.65368937
14sister chromatid segregation (GO:0000819)4.64564881
15DNA replication initiation (GO:0006270)4.59382124
16regulation of histone H3-K4 methylation (GO:0051569)4.58457362
17regulation of histone H3-K27 methylation (GO:0061085)4.56528529
18formation of translation preinitiation complex (GO:0001731)4.54059043
19homocysteine metabolic process (GO:0050667)4.52144786
20nuclear envelope disassembly (GO:0051081)4.36980482
21membrane disassembly (GO:0030397)4.36980482
22mitotic chromosome condensation (GO:0007076)4.36252255
23protoporphyrinogen IX metabolic process (GO:0046501)4.31682731
24synapsis (GO:0007129)4.22591641
25DNA strand elongation involved in DNA replication (GO:0006271)4.21918685
26proline biosynthetic process (GO:0006561)4.17623094
27DNA strand elongation (GO:0022616)4.11363637
28tRNA aminoacylation for protein translation (GO:0006418)4.07443514
29terpenoid biosynthetic process (GO:0016114)3.99156715
30amino acid activation (GO:0043038)3.92074925
31tRNA aminoacylation (GO:0043039)3.92074925
32DNA methylation involved in gamete generation (GO:0043046)3.86009450
33folic acid-containing compound biosynthetic process (GO:0009396)3.82663343
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.79146140
35regulation of nucleobase-containing compound transport (GO:0032239)3.78414059
36purine nucleobase biosynthetic process (GO:0009113)3.77910331
37telomere maintenance via semi-conservative replication (GO:0032201)3.73920852
38oxidative phosphorylation (GO:0006119)3.72348553
39gas transport (GO:0015669)3.70776510
40Golgi transport vesicle coating (GO:0048200)3.67507609
41COPI coating of Golgi vesicle (GO:0048205)3.67507609
42regulation of mitotic spindle organization (GO:0060236)3.64763256
43protoporphyrinogen IX biosynthetic process (GO:0006782)3.64635046
44negative regulation of erythrocyte differentiation (GO:0045647)3.64366620
45vitamin A metabolic process (GO:0006776)3.61026211
46regulation of translational elongation (GO:0006448)3.54613329
47IMP biosynthetic process (GO:0006188)3.52024314
48definitive hemopoiesis (GO:0060216)3.49108665
49oxaloacetate metabolic process (GO:0006107)3.45972588
50regulation of histone methylation (GO:0031060)3.44349313
51ribosomal large subunit biogenesis (GO:0042273)3.42897130
52chromosome segregation (GO:0007059)3.42330815
53nucleobase biosynthetic process (GO:0046112)3.37607196
54oxygen transport (GO:0015671)3.36466904
55mitotic recombination (GO:0006312)3.35705903
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34560249
57microtubule depolymerization (GO:0007019)3.33873418
58gonadal mesoderm development (GO:0007506)3.33222826
59tetrahydrofolate metabolic process (GO:0046653)3.32116413
60erythrocyte maturation (GO:0043249)3.30902855
61telomere maintenance via recombination (GO:0000722)3.30154677
62response to vitamin A (GO:0033189)3.22368936
63protein export from nucleus (GO:0006611)3.20671879
64chromosome condensation (GO:0030261)3.19180974
65protein localization to kinetochore (GO:0034501)3.11796587
66nuclear envelope organization (GO:0006998)3.11691814
67protein localization to chromosome, centromeric region (GO:0071459)3.08872216
68regulation of centriole replication (GO:0046599)3.06199099
69IMP metabolic process (GO:0046040)3.06138674
70intra-S DNA damage checkpoint (GO:0031573)3.05956797
71kinetochore organization (GO:0051383)3.05361287
72DNA conformation change (GO:0071103)3.02182963
73iron ion import (GO:0097286)3.01164843
74DNA packaging (GO:0006323)3.00391522
75negative regulation of histone methylation (GO:0031061)3.00180800
76midgut development (GO:0007494)2.95482128
77poly(A)+ mRNA export from nucleus (GO:0016973)2.93317961
78regulation of centrosome cycle (GO:0046605)2.91303495
79ribosome biogenesis (GO:0042254)2.89650119
80DNA synthesis involved in DNA repair (GO:0000731)2.87691977
81ribonucleoprotein complex biogenesis (GO:0022613)2.87558725
82positive regulation of histone H3-K4 methylation (GO:0051571)2.87234131
83granulocyte differentiation (GO:0030851)2.86921451
84DNA duplex unwinding (GO:0032508)2.84917110
85ribosomal small subunit assembly (GO:0000028)2.83625996
86creatine metabolic process (GO:0006600)2.82913010
87mitotic sister chromatid cohesion (GO:0007064)2.80762236
88centriole assembly (GO:0098534)2.80437306
89erythrocyte development (GO:0048821)2.79579010
90DNA geometric change (GO:0032392)2.79228943
91viral transcription (GO:0019083)2.79105134
92translational termination (GO:0006415)2.76790533
93mitotic metaphase plate congression (GO:0007080)2.76330345
94mRNA transport (GO:0051028)2.75238358
95negative regulation of potassium ion transmembrane transport (GO:1901380)2.72673345
96regulation of histone H3-K9 methylation (GO:0051570)2.71265090
97regulation of spindle organization (GO:0090224)2.70729371
98chromosome organization involved in meiosis (GO:0070192)2.69462313
99sensory perception of smell (GO:0007608)2.69028960
100translational initiation (GO:0006413)2.68987624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.27235933
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.03247379
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.86455998
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.68129107
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.51667385
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40652124
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.16158373
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97612488
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88253179
10NCOR1_26117541_ChIP-Seq_K562_Human2.64417604
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56687741
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51516793
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43524651
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.41387927
15XRN2_22483619_ChIP-Seq_HELA_Human2.37993961
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.36071029
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.34359212
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31116804
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26402506
20GATA1_19941826_ChIP-Seq_K562_Human2.19648282
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14440374
22DCP1A_22483619_ChIP-Seq_HELA_Human2.06492001
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.06369142
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.06191592
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00189652
26TTF2_22483619_ChIP-Seq_HELA_Human1.99625264
27ZNF263_19887448_ChIP-Seq_K562_Human1.97397817
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96025211
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95968822
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.95080428
31AR_21909140_ChIP-Seq_LNCAP_Human1.93530834
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88185848
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80249950
34ELK1_19687146_ChIP-ChIP_HELA_Human1.78446077
35GATA1_22025678_ChIP-Seq_K562_Human1.77861664
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75392987
37KDM5A_27292631_Chip-Seq_BREAST_Human1.71100353
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65706408
39GATA2_19941826_ChIP-Seq_K562_Human1.64048699
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63270964
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61211033
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59181386
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59073865
44FOXP3_21729870_ChIP-Seq_TREG_Human1.59017437
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57618557
46VDR_23849224_ChIP-Seq_CD4+_Human1.54785430
47CIITA_25753668_ChIP-Seq_RAJI_Human1.52491894
48GABP_19822575_ChIP-Seq_HepG2_Human1.48444018
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45369919
50MYC_22102868_ChIP-Seq_BL_Human1.44050579
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.39776568
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37663392
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36903420
54CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36035662
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33901735
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33402546
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33302615
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32909312
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32561528
60TFEB_21752829_ChIP-Seq_HELA_Human1.31355827
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28862519
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28403347
63SPI1_23127762_ChIP-Seq_K562_Human1.28125896
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25082189
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18726785
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17382083
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17265905
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.16437420
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15464474
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13344522
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10992557
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10449270
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.10363565
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10019495
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09285064
76SCL_19346495_ChIP-Seq_HPC-7_Human1.07851634
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05306186
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03751122
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01592461
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01544205
81CHD1_26751641_Chip-Seq_LNCaP_Human1.01150705
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99233202
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99111470
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97672810
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97373922
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95270847
87WT1_19549856_ChIP-ChIP_CCG9911_Human0.94356634
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91737475
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88010009
90TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87851992
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86461958
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86365168
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.83810854
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.79178856
95MAF_26560356_Chip-Seq_TH1_Human0.79078203
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78903086
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77469675
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75415142
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75381069
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.73756895

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog4.03439969
2MP0004147_increased_porphyrin_level3.93367278
3MP0008058_abnormal_DNA_repair3.80596661
4MP0005451_abnormal_body_composition3.77477091
5MP0008995_early_reproductive_senescence3.72293378
6MP0010094_abnormal_chromosome_stability3.69514580
7MP0003111_abnormal_nucleus_morphology3.55538979
8MP0008057_abnormal_DNA_replication3.39581934
9MP0003693_abnormal_embryo_hatching3.34922096
10MP0000678_abnormal_parathyroid_gland2.81484744
11MP0003656_abnormal_erythrocyte_physiolo2.78314653
12MP0009697_abnormal_copulation2.76315877
13MP0008932_abnormal_embryonic_tissue2.76024723
14MP0003077_abnormal_cell_cycle2.68171845
15MP0005083_abnormal_biliary_tract2.59809305
16MP0008007_abnormal_cellular_replicative2.57007672
17MP0003786_premature_aging2.53523593
18MP0004233_abnormal_muscle_weight2.09160569
19MP0010307_abnormal_tumor_latency2.04791539
20MP0005397_hematopoietic_system_phenotyp1.90143119
21MP0001545_abnormal_hematopoietic_system1.90143119
22MP0006035_abnormal_mitochondrial_morpho1.82814658
23MP0002396_abnormal_hematopoietic_system1.82096538
24MP0003718_maternal_effect1.81239314
25MP0001730_embryonic_growth_arrest1.80508284
26MP0000350_abnormal_cell_proliferation1.79672187
27MP0004145_abnormal_muscle_electrophysio1.71672984
28MP0002877_abnormal_melanocyte_morpholog1.66253835
29MP0001697_abnormal_embryo_size1.65794212
30MP0006036_abnormal_mitochondrial_physio1.61412448
31MP0002080_prenatal_lethality1.53397729
32MP0005380_embryogenesis_phenotype1.52683585
33MP0001672_abnormal_embryogenesis/_devel1.52683585
34MP0002132_abnormal_respiratory_system1.51003900
35MP0002210_abnormal_sex_determination1.50124480
36MP0000313_abnormal_cell_death1.48777986
37MP0001929_abnormal_gametogenesis1.46568261
38MP0004808_abnormal_hematopoietic_stem1.45062320
39MP0003984_embryonic_growth_retardation1.44498422
40MP0005408_hypopigmentation1.44011053
41MP0000372_irregular_coat_pigmentation1.42829759
42MP0001661_extended_life_span1.42286329
43MP0003221_abnormal_cardiomyocyte_apopto1.40223899
44MP0002009_preneoplasia1.40182263
45MP0002088_abnormal_embryonic_growth/wei1.38690289
46MP0002086_abnormal_extraembryonic_tissu1.32590532
47MP0005076_abnormal_cell_differentiation1.27723810
48MP0003959_abnormal_lean_body1.26730578
49MP0009278_abnormal_bone_marrow1.25068079
50MP0003186_abnormal_redox_activity1.24586836
51MP0005171_absent_coat_pigmentation1.18569668
52MP0000358_abnormal_cell_content/1.14777735
53MP0001727_abnormal_embryo_implantation1.13722656
54MP0001145_abnormal_male_reproductive1.09578742
55MP0002269_muscular_atrophy1.09279057
56MP0002019_abnormal_tumor_incidence1.05362112
57MP0003698_abnormal_male_reproductive1.05186079
58MP0002084_abnormal_developmental_patter1.04595567
59MP0008775_abnormal_heart_ventricle1.01869877
60MP0000653_abnormal_sex_gland0.99877334
61MP0003806_abnormal_nucleotide_metabolis0.98486195
62MP0002085_abnormal_embryonic_tissue0.97953754
63MP0000703_abnormal_thymus_morphology0.97509071
64MP0003950_abnormal_plasma_membrane0.97286018
65MP0003385_abnormal_body_wall0.96353787
66MP0005636_abnormal_mineral_homeostasis0.90965868
67MP0000747_muscle_weakness0.88276174
68MP0000647_abnormal_sebaceous_gland0.87097462
69MP0003699_abnormal_female_reproductive0.86003331
70MP0000609_abnormal_liver_physiology0.85778345
71MP0002249_abnormal_larynx_morphology0.84067788
72MP0001764_abnormal_homeostasis0.83751377
73MP0005410_abnormal_fertilization0.82728194
74MP0004197_abnormal_fetal_growth/weight/0.82478860
75MP0002139_abnormal_hepatobiliary_system0.80310511
76MP0002161_abnormal_fertility/fecundity0.80014763
77MP0001873_stomach_inflammation0.78061778
78MP0009931_abnormal_skin_appearance0.75682072
79MP0004084_abnormal_cardiac_muscle0.75118361
80MP0009115_abnormal_fat_cell0.74510099
81MP0010630_abnormal_cardiac_muscle0.74408249
82MP0003646_muscle_fatigue0.73255363
83MP0009703_decreased_birth_body0.73151028
84MP0002398_abnormal_bone_marrow0.72741346
85MP0001881_abnormal_mammary_gland0.72381638
86MP0002722_abnormal_immune_system0.72195597
87MP0008770_decreased_survivor_rate0.71665320
88MP0009672_abnormal_birth_weight0.71658936
89MP0000598_abnormal_liver_morphology0.70777855
90MP0005332_abnormal_amino_acid0.69056995
91MP0008877_abnormal_DNA_methylation0.67251599
92MP0003890_abnormal_embryonic-extraembry0.65046427
93MP0009333_abnormal_splenocyte_physiolog0.64360978
94MP0005384_cellular_phenotype0.63250291
95MP0003705_abnormal_hypodermis_morpholog0.63193967
96MP0002970_abnormal_white_adipose0.62753594
97MP0003567_abnormal_fetal_cardiomyocyte0.61196007
98MP0000681_abnormal_thyroid_gland0.59124791
99MP0004134_abnormal_chest_morphology0.58509152
100MP0002095_abnormal_skin_pigmentation0.57669734

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)6.93440925
2Cholecystitis (HP:0001082)6.93440925
3Truncus arteriosus (HP:0001660)6.04961976
4Reticulocytosis (HP:0001923)5.39901618
5Hyperthyroidism (HP:0000836)5.00019041
6Abnormality of reticulocytes (HP:0004312)4.64421992
7Ankyloglossia (HP:0010296)4.63717179
8Polycythemia (HP:0001901)4.57583377
9Birth length less than 3rd percentile (HP:0003561)4.31017020
10Bowel incontinence (HP:0002607)4.29250022
11Chromsome breakage (HP:0040012)4.11842526
12Abnormal large intestine physiology (HP:0012700)4.09667490
13Chromosomal breakage induced by crosslinking agents (HP:0003221)4.01800275
14Cortical dysplasia (HP:0002539)3.92463579
15Homocystinuria (HP:0002156)3.89041978
16Abnormality of homocysteine metabolism (HP:0010919)3.89041978
17Hypertensive crisis (HP:0100735)3.71979556
18Abnormality of glycolysis (HP:0004366)3.56406454
19Seborrheic dermatitis (HP:0001051)3.54066851
20Cholelithiasis (HP:0001081)3.49707309
21Upper limb muscle weakness (HP:0003484)3.41484881
22Abnormality of the heme biosynthetic pathway (HP:0010472)3.37915446
23Increased serum pyruvate (HP:0003542)3.37556137
24Acute myeloid leukemia (HP:0004808)3.33451468
25Abnormal hemoglobin (HP:0011902)3.32724074
26Abnormality of the tricuspid valve (HP:0001702)3.29325815
27Abnormality of oral frenula (HP:0000190)3.27988785
28Abnormality of cochlea (HP:0000375)3.27626283
29Ileus (HP:0002595)3.27143402
30Pallor (HP:0000980)3.22416893
31Hypoparathyroidism (HP:0000829)3.19724363
32Poikilocytosis (HP:0004447)3.13123963
33Abnormal gallbladder morphology (HP:0012437)3.09639136
34Reticulocytopenia (HP:0001896)3.05076116
35Atelectasis (HP:0100750)2.83056764
36Orthostatic hypotension (HP:0001278)2.71776874
37Morphological abnormality of the inner ear (HP:0011390)2.63026628
38Myelodysplasia (HP:0002863)2.59918273
39Hyperbilirubinemia (HP:0002904)2.57881184
40Abnormality of the gallbladder (HP:0005264)2.53490416
41Peripheral hypomyelination (HP:0007182)2.53000751
42Overlapping toe (HP:0001845)2.50058911
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.47543808
44Increased nuchal translucency (HP:0010880)2.46696602
45Acanthocytosis (HP:0001927)2.44236200
46Aplasia/Hypoplasia of the earlobes (HP:0009906)2.43519554
47Abnormally folded helix (HP:0008544)2.37142575
48Duplicated collecting system (HP:0000081)2.30353176
49Aplasia/Hypoplasia of the thymus (HP:0010515)2.29560898
50Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.29272144
51Tinnitus (HP:0000360)2.27946509
52Sandal gap (HP:0001852)2.26828915
53Nonimmune hydrops fetalis (HP:0001790)2.24715676
54Abnormality of the preputium (HP:0100587)2.24074650
55Short middle phalanx of the 5th finger (HP:0004220)2.23020048
56Breech presentation (HP:0001623)2.22635479
57Abnormality of chromosome stability (HP:0003220)2.17256329
58Abnormality of cells of the erythroid lineage (HP:0012130)2.12434856
59Flat cornea (HP:0007720)2.11436184
60Abnormality of DNA repair (HP:0003254)2.10962618
61Small intestinal stenosis (HP:0012848)2.09232022
62Duodenal stenosis (HP:0100867)2.09232022
63Macrocytic anemia (HP:0001972)2.09140831
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.09079836
65Premature ovarian failure (HP:0008209)2.07289967
66Attention deficit hyperactivity disorder (HP:0007018)2.02771457
67Dysmetric saccades (HP:0000641)1.98189289
68Obsessive-compulsive behavior (HP:0000722)1.98081762
69Increased connective tissue (HP:0009025)1.97379707
70Cheekbone underdevelopment (HP:0010669)1.96068023
71Abnormality of the renal collecting system (HP:0004742)1.94204225
72Cafe-au-lait spot (HP:0000957)1.93507830
73Breast hypoplasia (HP:0003187)1.87881245
74Patellar dislocation (HP:0002999)1.87403125
75Fatigue (HP:0012378)1.86931488
76Overfolded helix (HP:0000396)1.86910930
77Male infertility (HP:0003251)1.86746087
78Termporal pattern (HP:0011008)1.86334005
79Insidious onset (HP:0003587)1.86334005
80Abnormal number of erythroid precursors (HP:0012131)1.83796829
81Disproportionate tall stature (HP:0001519)1.79605693
82Abnormality of methionine metabolism (HP:0010901)1.75968748
83Deep philtrum (HP:0002002)1.75384019
84Angiofibromas (HP:0010615)1.75307372
85Adenoma sebaceum (HP:0009720)1.75307372
86Entropion (HP:0000621)1.74431664
87Venous insufficiency (HP:0005293)1.71770445
88Insomnia (HP:0100785)1.68924011
89Decreased subcutaneous fat (HP:0001002)1.65677726
90Relative macrocephaly (HP:0004482)1.64124251
91Progressive external ophthalmoplegia (HP:0000590)1.61637544
92Abnormality of the fingertips (HP:0001211)1.61341326
93Septate vagina (HP:0001153)1.60292438
94Pheochromocytoma (HP:0002666)1.59136039
95Abnormality of the carotid arteries (HP:0005344)1.58562130
96Long foot (HP:0001833)1.57344429
97Secondary amenorrhea (HP:0000869)1.53593786
98Abnormality of the thymus (HP:0000777)1.53426778
99Autoamputation (HP:0001218)1.52728766
100Choanal atresia (HP:0000453)1.52645145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.66771540
2KSR23.70945227
3TTK3.69600754
4EIF2AK13.58995517
5BMPR23.35425071
6EEF2K3.03036854
7CLK12.80417080
8MAP3K22.71888746
9RAF12.51181509
10CDC72.42931141
11SCYL22.38253750
12CCNB12.37920071
13NTRK32.34686390
14NEK12.21547127
15BRSK22.18590271
16WEE12.09998363
17CDK122.01793363
18PBK1.98962173
19PLK41.94944163
20KSR11.87197453
21NEK21.71333548
22SRPK11.70401051
23BUB11.62934321
24PDK21.62332704
25TSSK61.62211304
26NME11.53098427
27MAP3K81.41802618
28IRAK31.40893844
29ICK1.35450196
30RPS6KB21.34041908
31EIF2AK31.32893463
32CHEK21.25490107
33TRPM71.22613668
34BMX1.16277520
35BRSK11.11735957
36PIK3CG1.06155474
37MAP3K41.03989164
38CHEK11.02953982
39ATR1.01083321
40ALK0.99140302
41JAK20.87956536
42STK30.87233454
43PRPF4B0.85745990
44YES10.84700497
45BRAF0.82906063
46CDK10.80357538
47PLK30.78793322
48ATM0.77771023
49RET0.77421552
50BRD40.76232758
51WNK40.75645095
52AKT30.75220087
53STK40.75067973
54NME20.74604516
55CDK20.73532008
56PLK10.70308591
57PAK10.69521425
58AURKB0.67990557
59MAP2K10.67040612
60MAP3K10.66472992
61MTOR0.60103195
62MKNK10.58297879
63NTRK10.58047487
64WNK10.56616512
65MARK30.55727479
66JAK30.54811628
67MST40.54746157
68MAP3K60.52152666
69CSNK2A20.50800474
70CDK70.50350680
71TEC0.49996716
72LATS10.48635365
73MATK0.47314570
74TAOK20.47125628
75BTK0.47030807
76MAPKAPK50.45584426
77PASK0.45421669
78CSNK1E0.45404475
79PAK20.43855704
80PIM10.42373448
81MAPK100.41979979
82NEK60.38526262
83ILK0.38356529
84MAPK140.35178192
85GSK3B0.35087183
86CSNK2A10.34340328
87CDK40.32684112
88LATS20.31111688
89PRKDC0.29343742
90MUSK0.28550035
91LRRK20.28400080
92CDK30.27730462
93SGK10.26172740
94RPS6KA40.24987011
95AURKA0.24695869
96PTK60.24624583
97MAPK30.24305066
98EIF2AK20.23570852
99AKT10.23233210
100EPHA30.23198200

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.66530532
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.22114837
3DNA replication_Homo sapiens_hsa030303.67751672
4Mismatch repair_Homo sapiens_hsa034303.66479751
5One carbon pool by folate_Homo sapiens_hsa006703.39546244
6Homologous recombination_Homo sapiens_hsa034402.78002265
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65675859
8RNA transport_Homo sapiens_hsa030132.47079614
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.36400899
10Nucleotide excision repair_Homo sapiens_hsa034202.30528573
11Ribosome_Homo sapiens_hsa030102.26813870
12Cell cycle_Homo sapiens_hsa041102.22595383
13Spliceosome_Homo sapiens_hsa030402.10938700
14Fanconi anemia pathway_Homo sapiens_hsa034602.06709681
15Biosynthesis of amino acids_Homo sapiens_hsa012301.85643937
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.78528314
17Pyruvate metabolism_Homo sapiens_hsa006201.69210522
18Carbon metabolism_Homo sapiens_hsa012001.68066115
19Basal transcription factors_Homo sapiens_hsa030221.59607461
20mRNA surveillance pathway_Homo sapiens_hsa030151.50376627
21Base excision repair_Homo sapiens_hsa034101.46437637
22Acute myeloid leukemia_Homo sapiens_hsa052211.41810463
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38477846
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.33913095
25Steroid biosynthesis_Homo sapiens_hsa001001.32242372
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31426896
27Thyroid cancer_Homo sapiens_hsa052161.28288327
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27218267
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26327607
30Non-homologous end-joining_Homo sapiens_hsa034501.25404411
31Chronic myeloid leukemia_Homo sapiens_hsa052201.24487999
32Pentose phosphate pathway_Homo sapiens_hsa000301.16407669
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16274662
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15285959
35Arginine biosynthesis_Homo sapiens_hsa002201.12688043
36RNA polymerase_Homo sapiens_hsa030201.09544129
37Fructose and mannose metabolism_Homo sapiens_hsa000511.09204755
38RNA degradation_Homo sapiens_hsa030181.07289173
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04154735
40Proteasome_Homo sapiens_hsa030501.00448240
41Selenocompound metabolism_Homo sapiens_hsa004500.98078164
42Olfactory transduction_Homo sapiens_hsa047400.92599062
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90641401
44Oocyte meiosis_Homo sapiens_hsa041140.87866245
45Pancreatic cancer_Homo sapiens_hsa052120.87827840
46mTOR signaling pathway_Homo sapiens_hsa041500.87368643
47Pyrimidine metabolism_Homo sapiens_hsa002400.86147464
48Type II diabetes mellitus_Homo sapiens_hsa049300.85896389
49Parkinsons disease_Homo sapiens_hsa050120.85137586
50ErbB signaling pathway_Homo sapiens_hsa040120.82292681
51Non-small cell lung cancer_Homo sapiens_hsa052230.81570461
52Propanoate metabolism_Homo sapiens_hsa006400.81191023
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.80158797
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77919595
55HIF-1 signaling pathway_Homo sapiens_hsa040660.77588921
56Renal cell carcinoma_Homo sapiens_hsa052110.77282366
57Other glycan degradation_Homo sapiens_hsa005110.76859723
58Purine metabolism_Homo sapiens_hsa002300.76124971
59Huntingtons disease_Homo sapiens_hsa050160.74724128
60Viral carcinogenesis_Homo sapiens_hsa052030.73542146
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72791356
62VEGF signaling pathway_Homo sapiens_hsa043700.72454903
63Oxidative phosphorylation_Homo sapiens_hsa001900.70923803
64Fatty acid metabolism_Homo sapiens_hsa012120.64968204
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61617481
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59964538
67N-Glycan biosynthesis_Homo sapiens_hsa005100.57183372
68Protein export_Homo sapiens_hsa030600.56800144
69Insulin signaling pathway_Homo sapiens_hsa049100.56393273
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53895573
71Prolactin signaling pathway_Homo sapiens_hsa049170.44830215
72MicroRNAs in cancer_Homo sapiens_hsa052060.44621086
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44307372
74Prion diseases_Homo sapiens_hsa050200.44120356
75Butanoate metabolism_Homo sapiens_hsa006500.43305121
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42085658
77Epstein-Barr virus infection_Homo sapiens_hsa051690.40117385
78Galactose metabolism_Homo sapiens_hsa000520.39671211
79Glioma_Homo sapiens_hsa052140.39549104
80Bladder cancer_Homo sapiens_hsa052190.37914102
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36732492
82Alzheimers disease_Homo sapiens_hsa050100.36617866
83Lysine degradation_Homo sapiens_hsa003100.36047936
84Hepatitis B_Homo sapiens_hsa051610.33886340
85Metabolic pathways_Homo sapiens_hsa011000.32810894
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.30857575
87Fatty acid biosynthesis_Homo sapiens_hsa000610.30367347
88B cell receptor signaling pathway_Homo sapiens_hsa046620.29428418
89Colorectal cancer_Homo sapiens_hsa052100.28867863
90Dorso-ventral axis formation_Homo sapiens_hsa043200.25983725
91Glutathione metabolism_Homo sapiens_hsa004800.25786611
92Fatty acid elongation_Homo sapiens_hsa000620.25726009
93Endometrial cancer_Homo sapiens_hsa052130.25269722
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25123578
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23752043
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20762570
97Choline metabolism in cancer_Homo sapiens_hsa052310.19484198
98Shigellosis_Homo sapiens_hsa051310.18715863
99Vitamin B6 metabolism_Homo sapiens_hsa007500.18492548
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.18415548

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