SALL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing multiple zinc finger domains. The encoded protein functions in optical fissure closure during development of the eye in the embryo. Mutations in this gene are associated with ocular coloboma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.89284562
2regulation of gene silencing by miRNA (GO:0060964)5.89284562
3regulation of gene silencing by RNA (GO:0060966)5.89284562
4locomotory exploration behavior (GO:0035641)5.28748687
5paraxial mesoderm development (GO:0048339)4.77658390
6layer formation in cerebral cortex (GO:0021819)4.73703362
7heterochromatin organization (GO:0070828)4.73549425
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.58222612
9synaptic vesicle maturation (GO:0016188)4.48146683
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.37680126
11L-serine metabolic process (GO:0006563)4.21764262
12establishment of integrated proviral latency (GO:0075713)4.20520757
13dendritic spine morphogenesis (GO:0060997)4.16807689
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04945804
15vocalization behavior (GO:0071625)4.04303776
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.98839666
17synaptic vesicle exocytosis (GO:0016079)3.90252339
18exploration behavior (GO:0035640)3.87843168
19presynaptic membrane assembly (GO:0097105)3.80744817
20convergent extension (GO:0060026)3.80412769
21regulation of glutamate receptor signaling pathway (GO:1900449)3.77547716
22synaptic vesicle docking involved in exocytosis (GO:0016081)3.72211562
23axonal fasciculation (GO:0007413)3.68285294
24DNA unwinding involved in DNA replication (GO:0006268)3.67599189
25establishment of nucleus localization (GO:0040023)3.62588080
26protein localization to kinetochore (GO:0034501)3.56242626
27neuron cell-cell adhesion (GO:0007158)3.55496886
28chromatin remodeling at centromere (GO:0031055)3.55357223
29regulation of cell fate specification (GO:0042659)3.52640173
30glutamate secretion (GO:0014047)3.51095279
31neuron recognition (GO:0008038)3.49768903
32innervation (GO:0060384)3.48643484
33ionotropic glutamate receptor signaling pathway (GO:0035235)3.47633998
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.45938383
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.45938383
36regulation of translation, ncRNA-mediated (GO:0045974)3.45938383
37regulation of synaptic vesicle exocytosis (GO:2000300)3.44458946
38protein localization to synapse (GO:0035418)3.42950218
39sodium ion export (GO:0071436)3.35978975
40regulation of synapse structural plasticity (GO:0051823)3.34420778
41presynaptic membrane organization (GO:0097090)3.34389115
42auditory behavior (GO:0031223)3.34336626
43lung-associated mesenchyme development (GO:0060484)3.34312009
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33951589
45neurotransmitter secretion (GO:0007269)3.33230237
46regulation of neuronal synaptic plasticity (GO:0048168)3.32431959
47cell migration in hindbrain (GO:0021535)3.29853089
48positive regulation of synapse maturation (GO:0090129)3.25225162
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21552061
50dendrite morphogenesis (GO:0048813)3.21233569
51nucleosome disassembly (GO:0006337)3.20168675
52protein-DNA complex disassembly (GO:0032986)3.20168675
53CENP-A containing nucleosome assembly (GO:0034080)3.19367055
54cellular potassium ion homeostasis (GO:0030007)3.19075711
55neuromuscular process controlling balance (GO:0050885)3.18692012
56protein complex localization (GO:0031503)3.18363081
57cell communication by electrical coupling (GO:0010644)3.17874122
58G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.17437342
59notochord development (GO:0030903)3.16387067
60gamma-aminobutyric acid transport (GO:0015812)3.13881164
61cerebellar Purkinje cell differentiation (GO:0021702)3.13037947
62negative regulation of microtubule polymerization (GO:0031115)3.11334668
63regulation of gene silencing (GO:0060968)3.10919132
64synaptic transmission, glutamatergic (GO:0035249)3.10792284
65glutamate receptor signaling pathway (GO:0007215)3.10572926
66establishment of viral latency (GO:0019043)3.07076706
67DNA replication-independent nucleosome assembly (GO:0006336)3.06642049
68DNA replication-independent nucleosome organization (GO:0034724)3.06642049
69response to auditory stimulus (GO:0010996)3.03162287
70ATP-dependent chromatin remodeling (GO:0043044)3.02257955
71pre-miRNA processing (GO:0031054)3.01177959
72pyrimidine nucleobase catabolic process (GO:0006208)3.00953220
73outer ear morphogenesis (GO:0042473)2.99355752
74lateral sprouting from an epithelium (GO:0060601)2.97267176
75regulation of synaptic vesicle transport (GO:1902803)2.96882097
76central nervous system projection neuron axonogenesis (GO:0021952)2.96826991
77DNA strand elongation involved in DNA replication (GO:0006271)2.96117345
78cellular sodium ion homeostasis (GO:0006883)2.95720042
79regulation of helicase activity (GO:0051095)2.95237136
80dendritic spine organization (GO:0097061)2.94795321
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94273827
82neuronal action potential propagation (GO:0019227)2.93851704
83transmission of nerve impulse (GO:0019226)2.92684026
84negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92519605
85negative regulation of gene silencing (GO:0060969)2.92262917
86postsynaptic membrane organization (GO:0001941)2.91176016
87histone exchange (GO:0043486)2.90993785
88regulation of histone H3-K9 methylation (GO:0051570)2.90335499
89IMP biosynthetic process (GO:0006188)2.89377538
90long-term memory (GO:0007616)2.88997494
91planar cell polarity pathway involved in neural tube closure (GO:0090179)2.86812239
92positive regulation of SMAD protein import into nucleus (GO:0060391)2.86373235
93neuronal ion channel clustering (GO:0045161)2.85772679
94proline transport (GO:0015824)2.85484760
95regulation of dendritic spine morphogenesis (GO:0061001)2.85393524
96regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.83402632
97DNA replication-dependent nucleosome organization (GO:0034723)2.82413638
98DNA replication-dependent nucleosome assembly (GO:0006335)2.82413638
99neuron-neuron synaptic transmission (GO:0007270)2.80645822
100DNA strand elongation (GO:0022616)2.79943539
101mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.79404263
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78472257
103negative regulation of sodium ion transport (GO:0010766)2.78412110
104negative regulation of histone methylation (GO:0031061)2.77875808
105positive regulation of dendritic spine morphogenesis (GO:0061003)2.76996353
106cochlea development (GO:0090102)2.76231436
107protein localization to chromosome, centromeric region (GO:0071459)2.76168915
108DNA replication checkpoint (GO:0000076)2.74971885
109chromatin assembly (GO:0031497)2.73797863
110DNA damage response, detection of DNA damage (GO:0042769)2.72982883
111regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70255344
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70021422
113regulation of stem cell maintenance (GO:2000036)2.68779183
114synaptic vesicle endocytosis (GO:0048488)2.68641014
115nuclear pore complex assembly (GO:0051292)2.68517785
116neurotransmitter-gated ion channel clustering (GO:0072578)2.68149226
117membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65601791
118neuroblast proliferation (GO:0007405)2.65584443
119IMP metabolic process (GO:0046040)2.65238579
120glial cell proliferation (GO:0014009)2.64677904
121histone arginine methylation (GO:0034969)2.63776875
122negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.62514666
123synapse organization (GO:0050808)2.62341794
124mechanosensory behavior (GO:0007638)2.62234082
125prepulse inhibition (GO:0060134)2.62006111
126neurotransmitter transport (GO:0006836)2.61466428
127regulation of non-canonical Wnt signaling pathway (GO:2000050)2.61365749
128inner ear receptor cell development (GO:0060119)2.61059994
129synapse assembly (GO:0007416)2.61013593
130dorsal/ventral axis specification (GO:0009950)2.60828427
131regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.60676908
132cerebellar granule cell differentiation (GO:0021707)2.60426969
133establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.60171013
134positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59143865
135somatic hypermutation of immunoglobulin genes (GO:0016446)2.58943572
136somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58943572
137mitotic metaphase plate congression (GO:0007080)2.58597231
138positive regulation of synapse assembly (GO:0051965)2.57903526
139activation of protein kinase A activity (GO:0034199)2.57889616
140regulation of synaptic plasticity (GO:0048167)2.57490540
141response to pheromone (GO:0019236)2.57120699
142positive regulation of synaptic transmission, GABAergic (GO:0032230)2.56771562
143regulation of cell fate commitment (GO:0010453)2.55870579
144neuromuscular process (GO:0050905)2.55143127
145cerebellar Purkinje cell layer development (GO:0021680)2.55103977
146DNA strand renaturation (GO:0000733)2.54658474
147lysine catabolic process (GO:0006554)2.54512656
148lysine metabolic process (GO:0006553)2.54512656
149cell fate commitment involved in formation of primary germ layer (GO:0060795)2.54436181
150chromatin assembly or disassembly (GO:0006333)2.54005469
151negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.53692492
152negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.53692492
153negative regulation of mitotic sister chromatid segregation (GO:0033048)2.53692492
154negative regulation of mitotic sister chromatid separation (GO:2000816)2.53692492
155negative regulation of sister chromatid segregation (GO:0033046)2.53692492
156negative regulation of chromosome segregation (GO:0051985)2.53207115
157positive regulation of membrane potential (GO:0045838)2.53017633
158neuronal stem cell maintenance (GO:0097150)2.51947573
159nuclear pore organization (GO:0006999)2.51523036
160mesenchymal to epithelial transition (GO:0060231)2.51496166
161membrane hyperpolarization (GO:0060081)2.51247259
162regulation of respiratory system process (GO:0044065)2.50897170
163purine nucleobase biosynthetic process (GO:0009113)2.50131052
164long-term synaptic potentiation (GO:0060291)2.49667512
165behavioral fear response (GO:0001662)2.49049461
166behavioral defense response (GO:0002209)2.49049461
167vesicle transport along microtubule (GO:0047496)2.48594608
168pituitary gland development (GO:0021983)2.48562661
169Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.48366790
170apical protein localization (GO:0045176)2.48229006
171regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.47715684
172regulation of telomere maintenance via telomerase (GO:0032210)2.47607715
173establishment of planar polarity (GO:0001736)2.46798330
174establishment of tissue polarity (GO:0007164)2.46798330
175serine family amino acid biosynthetic process (GO:0009070)2.45883569
176ribosomal small subunit assembly (GO:0000028)2.45185228
177nucleobase biosynthetic process (GO:0046112)2.44809563
178cerebellum development (GO:0021549)2.43468713
179cell differentiation in hindbrain (GO:0021533)2.43425036
180regulation of excitatory postsynaptic membrane potential (GO:0060079)2.43087087
181regulation of postsynaptic membrane potential (GO:0060078)2.42901580
182regulation of chromatin silencing (GO:0031935)2.42540893
183peptidyl-arginine methylation (GO:0018216)2.42420433
184generation of neurons (GO:0048699)2.42112086
185cranial nerve development (GO:0021545)2.42017656
186DNA ligation (GO:0006266)2.41731136
187negative regulation of DNA recombination (GO:0045910)2.41556557
188ncRNA catabolic process (GO:0034661)2.39870460
189negative regulation of mRNA processing (GO:0050686)2.39503394
190spindle checkpoint (GO:0031577)2.38663971
191mitotic sister chromatid segregation (GO:0000070)2.36864340
192somite development (GO:0061053)2.36638437
193sister chromatid segregation (GO:0000819)2.35732977

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.08223607
2EZH2_22144423_ChIP-Seq_EOC_Human5.63272848
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11717039
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.11682985
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90950755
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.90882210
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.90882210
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87212815
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.85667739
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.83978655
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.81317453
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.81053378
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77545078
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73467534
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.57089444
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.57089444
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.57089444
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56603625
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.51177513
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.46619482
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.46374186
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.41636683
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.40844694
24* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39915167
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.35256256
26* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34472806
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.30963897
28GBX2_23144817_ChIP-Seq_PC3_Human2.29650937
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25142584
30MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25079002
31RARB_27405468_Chip-Seq_BRAIN_Mouse2.23952460
32DROSHA_22980978_ChIP-Seq_HELA_Human2.22408721
33* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20881123
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.19902155
35SOX2_18555785_ChIP-Seq_MESCs_Mouse2.18426579
36* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16923666
37REST_21632747_ChIP-Seq_MESCs_Mouse2.14286231
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12212656
39ZFP281_18757296_ChIP-ChIP_E14_Mouse2.11723470
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07496537
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06417496
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.05955852
43ERG_21242973_ChIP-ChIP_JURKAT_Human2.05664903
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00213429
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.98800127
46* NANOG_16153702_ChIP-ChIP_HESCs_Human1.94551430
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90806489
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85553795
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85509008
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.83386341
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.82943209
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81444160
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81123328
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.80977754
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77380686
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.76436638
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75851763
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.75381672
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73751854
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.71079036
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.70273755
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.69831181
63AR_21572438_ChIP-Seq_LNCaP_Human1.65523173
64ZNF274_21170338_ChIP-Seq_K562_Hela1.65106907
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64814960
66* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61996216
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61806844
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58911055
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.58862929
70TCF3_18692474_ChIP-Seq_MESCs_Mouse1.58795572
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54782063
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.54073497
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52550029
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.52108308
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51516666
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51140100
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49811039
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.46720618
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46486341
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46079237
81POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.44657824
82XRN2_22483619_ChIP-Seq_HELA_Human1.44307462
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.44292979
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43356752
85KDM2B_26808549_Chip-Seq_K562_Human1.42841848
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41151015
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38465862
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37826441
89MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35911288
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35755557
91SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.34070103
92OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33487025
93IRF1_19129219_ChIP-ChIP_H3396_Human1.32300676
94TTF2_22483619_ChIP-Seq_HELA_Human1.32016480
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31315476
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30608658
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29431289
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.28127427
99NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.27599918
100EST1_17652178_ChIP-ChIP_JURKAT_Human1.26617513
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.26492157
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26406742
103AR_19668381_ChIP-Seq_PC3_Human1.25948442
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24651280
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24187034
106AR_21909140_ChIP-Seq_LNCAP_Human1.24064290
107* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23261506
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22578175
109CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21994758
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21847388
111* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21728884
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21655191
113MYC_18940864_ChIP-ChIP_HL60_Human1.18751605
114YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17367129
115ISL1_27105846_Chip-Seq_CPCs_Mouse1.16948365
116E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15982646
117SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13380907
118TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.12962330
119RNF2_27304074_Chip-Seq_NSC_Mouse1.12367036
120* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11246125
121SOX2_21211035_ChIP-Seq_LN229_Gbm1.10213280
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09656031
123EWS_26573619_Chip-Seq_HEK293_Human1.09331159
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09247772
125SMAD4_21799915_ChIP-Seq_A2780_Human1.08769732
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08712773
127* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07119902
128NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06992330
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06808524
130* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06390978
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06390667
132* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05839314
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.03838673
134KDM2B_26808549_Chip-Seq_JURKAT_Human1.00952679
135SMAD3_21741376_ChIP-Seq_ESCs_Human1.00446569
136HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99268723
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98410998
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98158679
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98158679
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.97669086
141BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97158416
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.95527201
143* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93937023
144STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93599394
145ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92561487
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92269620
147PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91575118
148GABP_17652178_ChIP-ChIP_JURKAT_Human0.91245792
149TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90326115
150KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88837061
151AHR_22903824_ChIP-Seq_MCF-7_Human0.88559487
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.88218438
153OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88010952
154FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87848585
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87618901
156P300_19829295_ChIP-Seq_ESCs_Human0.86636141
157NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86303338
158TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85583357
159SOX3_22085726_ChIP-Seq_NPCs_Mouse0.85124139
160SOX9_26525672_Chip-Seq_HEART_Mouse0.84994909
161STAT3_23295773_ChIP-Seq_U87_Human0.84913639
162NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84672953
163FUS_26573619_Chip-Seq_HEK293_Human0.84115304
164TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83856240
165AR_25329375_ChIP-Seq_VCAP_Human0.83825444
166TBX3_20139965_ChIP-Seq_ESCs_Mouse0.83762218
167IGF1R_20145208_ChIP-Seq_DFB_Human0.83552396
168KDM2B_26808549_Chip-Seq_DND41_Human0.83474697
169TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83415389
170POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83257594
171TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82583033

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.59685695
2MP0003635_abnormal_synaptic_transmissio2.90170127
3MP0003880_abnormal_central_pattern2.85733920
4MP0003136_yellow_coat_color2.44191651
5MP0003122_maternal_imprinting2.44108475
6MP0000778_abnormal_nervous_system2.39481812
7MP0005423_abnormal_somatic_nervous2.36583208
8MP0003693_abnormal_embryo_hatching2.35274632
9MP0004270_analgesia2.32589543
10MP0002063_abnormal_learning/memory/cond2.32259482
11MP0002254_reproductive_system_inflammat2.18754350
12MP0008877_abnormal_DNA_methylation2.17588394
13MP0009672_abnormal_birth_weight2.14556810
14MP0001486_abnormal_startle_reflex2.13907765
15MP0009745_abnormal_behavioral_response2.12241834
16MP0002653_abnormal_ependyma_morphology2.11140017
17MP0003941_abnormal_skin_development2.03964178
18MP0002064_seizures2.02368925
19MP0004957_abnormal_blastocyst_morpholog1.98893874
20MP0003111_abnormal_nucleus_morphology1.97895185
21MP0000537_abnormal_urethra_morphology1.97646429
22MP0004858_abnormal_nervous_system1.97610824
23MP0002697_abnormal_eye_size1.94865557
24MP0004885_abnormal_endolymph1.94715528
25MP0009046_muscle_twitch1.89442491
26MP0003283_abnormal_digestive_organ1.85192940
27MP0001485_abnormal_pinna_reflex1.83790039
28MP0005377_hearing/vestibular/ear_phenot1.83465608
29MP0003878_abnormal_ear_physiology1.83465608
30MP0002572_abnormal_emotion/affect_behav1.83330095
31MP0008932_abnormal_embryonic_tissue1.80088847
32MP0010030_abnormal_orbit_morphology1.78749220
33MP0010094_abnormal_chromosome_stability1.77633543
34MP0002184_abnormal_innervation1.75078552
35MP0003879_abnormal_hair_cell1.74548102
36MP0002938_white_spotting1.73616685
37MP0002272_abnormal_nervous_system1.65544815
38MP0003567_abnormal_fetal_cardiomyocyte1.64160798
39MP0003123_paternal_imprinting1.63679418
40MP0001968_abnormal_touch/_nociception1.63545723
41MP0009780_abnormal_chondrocyte_physiolo1.60717378
42MP0001286_abnormal_eye_development1.59639321
43MP0000955_abnormal_spinal_cord1.58432358
44MP0000534_abnormal_ureter_morphology1.57593016
45MP0003121_genomic_imprinting1.56551778
46MP0002734_abnormal_mechanical_nocicepti1.54045397
47MP0003942_abnormal_urinary_system1.52247053
48MP0000049_abnormal_middle_ear1.49075466
49MP0002557_abnormal_social/conspecific_i1.47988834
50MP0008058_abnormal_DNA_repair1.47901329
51MP0003787_abnormal_imprinting1.45865335
52MP0004811_abnormal_neuron_physiology1.44509158
53MP0002882_abnormal_neuron_morphology1.44334793
54MP0002067_abnormal_sensory_capabilities1.44100213
55MP0000631_abnormal_neuroendocrine_gland1.41811199
56MP0009379_abnormal_foot_pigmentation1.41712023
57MP0000026_abnormal_inner_ear1.41351506
58* MP0002085_abnormal_embryonic_tissue1.40396502
59* MP0002152_abnormal_brain_morphology1.38755027
60MP0008569_lethality_at_weaning1.38571868
61MP0000569_abnormal_digit_pigmentation1.37963830
62MP0003077_abnormal_cell_cycle1.37958768
63* MP0003861_abnormal_nervous_system1.36960119
64MP0002084_abnormal_developmental_patter1.36813591
65MP0002249_abnormal_larynx_morphology1.36739676
66MP0003938_abnormal_ear_development1.36514533
67MP0001963_abnormal_hearing_physiology1.34334183
68MP0009053_abnormal_anal_canal1.32286732
69MP0005499_abnormal_olfactory_system1.31534602
70MP0005394_taste/olfaction_phenotype1.31534602
71MP0003119_abnormal_digestive_system1.31319663
72MP0001299_abnormal_eye_distance/1.30437925
73MP0008057_abnormal_DNA_replication1.26567650
74MP0005623_abnormal_meninges_morphology1.25749178
75MP0009703_decreased_birth_body1.25721032
76MP0002111_abnormal_tail_morphology1.25182146
77MP0005187_abnormal_penis_morphology1.24949918
78MP0002092_abnormal_eye_morphology1.24727959
79MP0001188_hyperpigmentation1.22639085
80MP0003385_abnormal_body_wall1.20615864
81MP0004233_abnormal_muscle_weight1.19729190
82MP0001730_embryonic_growth_arrest1.19135095
83MP0001346_abnormal_lacrimal_gland1.19134701
84MP0001984_abnormal_olfaction1.18609166
85MP0005248_abnormal_Harderian_gland1.18488402
86MP0000579_abnormal_nail_morphology1.17096380
87MP0003115_abnormal_respiratory_system1.16433725
88MP0001440_abnormal_grooming_behavior1.16425143
89MP0006292_abnormal_olfactory_placode1.15787008
90MP0005646_abnormal_pituitary_gland1.15432426
91MP0000428_abnormal_craniofacial_morphol1.15325179
92MP0002736_abnormal_nociception_after1.15061804
93MP0002089_abnormal_postnatal_growth/wei1.11049779
94MP0002733_abnormal_thermal_nociception1.11029722
95MP0004924_abnormal_behavior1.10589418
96MP0005386_behavior/neurological_phenoty1.10589418
97MP0000566_synostosis1.10496658
98MP0002752_abnormal_somatic_nervous1.09332341
99MP0006072_abnormal_retinal_apoptosis1.09130093
100MP0004197_abnormal_fetal_growth/weight/1.08593558
101MP0005380_embryogenesis_phenotype1.08148419
102MP0001672_abnormal_embryogenesis/_devel1.08148419
103MP0006276_abnormal_autonomic_nervous1.07896852
104MP0002066_abnormal_motor_capabilities/c1.06552379
105MP0002234_abnormal_pharynx_morphology1.06544867
106MP0002822_catalepsy1.06506358
107MP0008789_abnormal_olfactory_epithelium1.03840921
108MP0001501_abnormal_sleep_pattern1.01696738
109MP0001502_abnormal_circadian_rhythm1.00815476
110MP0009250_abnormal_appendicular_skeleto0.98921394
111MP0001697_abnormal_embryo_size0.98218685
112MP0000432_abnormal_head_morphology0.97823272
113MP0003890_abnormal_embryonic-extraembry0.97679489
114MP0002116_abnormal_craniofacial_bone0.97296019
115MP0002932_abnormal_joint_morphology0.96556592
116MP0005645_abnormal_hypothalamus_physiol0.95112091
117MP0002909_abnormal_adrenal_gland0.94772349
118MP0001970_abnormal_pain_threshold0.94700275
119MP0002751_abnormal_autonomic_nervous0.93875832
120MP0005391_vision/eye_phenotype0.93337976
121MP0003718_maternal_effect0.92734200
122MP0003755_abnormal_palate_morphology0.92388821
123MP0002282_abnormal_trachea_morphology0.92194256
124MP0001177_atelectasis0.90124511
125MP0003984_embryonic_growth_retardation0.90113175
126MP0002233_abnormal_nose_morphology0.90046509
127MP0001849_ear_inflammation0.89538584
128MP0003329_amyloid_beta_deposits0.89171238
129MP0005551_abnormal_eye_electrophysiolog0.89163847
130MP0000350_abnormal_cell_proliferation0.89159910
131MP0004133_heterotaxia0.87926893
132MP0003937_abnormal_limbs/digits/tail_de0.87679944
133MP0003315_abnormal_perineum_morphology0.87638345
134MP0003935_abnormal_craniofacial_develop0.87606187
135MP0002088_abnormal_embryonic_growth/wei0.87494790
136MP0001529_abnormal_vocalization0.87179763
137MP0003634_abnormal_glial_cell0.86392664
138MP0002081_perinatal_lethality0.85690483
139MP0004742_abnormal_vestibular_system0.85453539
140MP0004145_abnormal_muscle_electrophysio0.85356350
141MP0001293_anophthalmia0.83798499

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)4.04609939
2Abnormality of the labia minora (HP:0012880)3.83626728
3Myokymia (HP:0002411)3.62406645
4Focal motor seizures (HP:0011153)3.31150678
5Cortical dysplasia (HP:0002539)3.04961183
6Focal seizures (HP:0007359)2.98289163
7Partial duplication of thumb phalanx (HP:0009944)2.93535905
8Maternal diabetes (HP:0009800)2.88342973
9Megalencephaly (HP:0001355)2.87805608
10Absent septum pellucidum (HP:0001331)2.75965067
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.69941088
12Short 4th metacarpal (HP:0010044)2.69941088
13Renal duplication (HP:0000075)2.67910197
14High anterior hairline (HP:0009890)2.67101193
15Visual hallucinations (HP:0002367)2.66838307
16Reticulocytopenia (HP:0001896)2.65780218
17Progressive cerebellar ataxia (HP:0002073)2.63727992
18Choanal stenosis (HP:0000452)2.57026865
19Abnormality of the septum pellucidum (HP:0007375)2.54530153
20Insomnia (HP:0100785)2.54036588
21Action tremor (HP:0002345)2.53607591
22Hyperacusis (HP:0010780)2.51817226
23Pointed chin (HP:0000307)2.49915037
24Spastic diplegia (HP:0001264)2.49200151
25Bilateral microphthalmos (HP:0007633)2.44894230
26Partial duplication of the phalanx of hand (HP:0009999)2.44566592
27Optic nerve hypoplasia (HP:0000609)2.42934023
28Abnormal lung lobation (HP:0002101)2.41109299
29Nephroblastoma (Wilms tumor) (HP:0002667)2.40233434
30Esophageal atresia (HP:0002032)2.40202017
31Intestinal atresia (HP:0011100)2.39410385
32Abnormality of the lower motor neuron (HP:0002366)2.35338725
33Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.34115561
34Aplasia involving bones of the upper limbs (HP:0009823)2.34045344
35Aplasia of the phalanges of the hand (HP:0009802)2.34045344
36Aplasia involving bones of the extremities (HP:0009825)2.34045344
37Mixed hearing impairment (HP:0000410)2.31889937
38Stenosis of the external auditory canal (HP:0000402)2.27566603
39Elfin facies (HP:0004428)2.25012973
40Abnormality of the 4th metacarpal (HP:0010012)2.24698913
41Duplication of thumb phalanx (HP:0009942)2.23173888
42Embryonal renal neoplasm (HP:0011794)2.22327242
43Hyperglycinemia (HP:0002154)2.22113777
44Abnormal hair whorl (HP:0010721)2.21396146
45Epileptic encephalopathy (HP:0200134)2.21179857
46Morphological abnormality of the middle ear (HP:0008609)2.20659952
47Meckel diverticulum (HP:0002245)2.19082095
48Hemivertebrae (HP:0002937)2.19014820
49Preaxial foot polydactyly (HP:0001841)2.16259854
50Genetic anticipation (HP:0003743)2.15423600
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.14163286
52Ectopic kidney (HP:0000086)2.11888707
53Hemiparesis (HP:0001269)2.09658505
54Turricephaly (HP:0000262)2.09613122
55Abnormality of cochlea (HP:0000375)2.09513764
56Overriding aorta (HP:0002623)2.09410896
57Ependymoma (HP:0002888)2.08782667
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08235624
59Bifid tongue (HP:0010297)2.07149240
60Gastrointestinal atresia (HP:0002589)2.07012609
61Abnormality of the ileum (HP:0001549)2.06912440
62Abnormality of the diencephalon (HP:0010662)2.06607372
63Depression (HP:0000716)2.06043927
64Medulloblastoma (HP:0002885)2.05563596
65Supranuclear gaze palsy (HP:0000605)2.04704286
66Trigonocephaly (HP:0000243)2.04315458
67Rib fusion (HP:0000902)2.03118407
68Breast aplasia (HP:0100783)2.01497614
69Vitreoretinal degeneration (HP:0000655)2.01449239
70Triphalangeal thumb (HP:0001199)2.01420408
71Synostosis involving the elbow (HP:0003938)2.01374402
72Humeroradial synostosis (HP:0003041)2.01374402
73Midline defect of the nose (HP:0004122)2.01282525
74Rectal fistula (HP:0100590)2.01204917
75Rectovaginal fistula (HP:0000143)2.01204917
76Atonic seizures (HP:0010819)1.99994531
77Absence seizures (HP:0002121)1.99704986
78Chromsome breakage (HP:0040012)1.99501729
79Ankyloglossia (HP:0010296)1.99498410
80Increased nuchal translucency (HP:0010880)1.99314171
81Ankle clonus (HP:0011448)1.98993430
82Renovascular hypertension (HP:0100817)1.98686587
83Aplasia/Hypoplasia of the breasts (HP:0010311)1.97990932
84Renal hypoplasia (HP:0000089)1.96647335
85Neoplasm of the heart (HP:0100544)1.96556720
86Oligodactyly (HP:0012165)1.96147462
87Impaired vibration sensation in the lower limbs (HP:0002166)1.95577483
88Truncal ataxia (HP:0002078)1.94251470
89Shallow orbits (HP:0000586)1.92441621
90Aqueductal stenosis (HP:0002410)1.91292537
91Myelomeningocele (HP:0002475)1.91136459
92Anophthalmia (HP:0000528)1.89401340
93Broad-based gait (HP:0002136)1.89042520
94Cutaneous finger syndactyly (HP:0010554)1.88864912
95Broad phalanx (HP:0006009)1.87965403
96Febrile seizures (HP:0002373)1.87106477
97Dysdiadochokinesis (HP:0002075)1.86175285
98Absent radius (HP:0003974)1.85230938
99Generalized hypotonia (HP:0001290)1.84561794
100Rhabdomyosarcoma (HP:0002859)1.83409694
101Abnormality of the antihelix (HP:0009738)1.83089844
102Omphalocele (HP:0001539)1.82993808
103Annular pancreas (HP:0001734)1.82562576
104Broad long bones (HP:0005622)1.81520078
105Sacral dimple (HP:0000960)1.80660189
106Cutaneous syndactyly (HP:0012725)1.79873131
107Hemiplegia (HP:0002301)1.79735833
108Excessive salivation (HP:0003781)1.79275448
109Drooling (HP:0002307)1.79275448
110Neoplasm of the adrenal cortex (HP:0100641)1.78924490
111Shoulder girdle muscle weakness (HP:0003547)1.78882409
112Obsessive-compulsive behavior (HP:0000722)1.78147955
113Vaginal fistula (HP:0004320)1.78046809
114Partial agenesis of the corpus callosum (HP:0001338)1.77512706
115Birth length less than 3rd percentile (HP:0003561)1.76981825
116Morphological abnormality of the inner ear (HP:0011390)1.75571402
117Absent forearm bone (HP:0003953)1.75439392
118Aplasia involving forearm bones (HP:0009822)1.75439392
119Broad foot (HP:0001769)1.75436287
120Urinary bladder sphincter dysfunction (HP:0002839)1.74814820
121Holoprosencephaly (HP:0001360)1.73430446
122Urinary urgency (HP:0000012)1.71968699
123Broad thumb (HP:0011304)1.71776011
124Abdominal situs inversus (HP:0003363)1.71648173
125Abnormality of abdominal situs (HP:0011620)1.71648173
126Hepatoblastoma (HP:0002884)1.71603557
127Intestinal fistula (HP:0100819)1.71456131
128Abnormality of the pubic bones (HP:0003172)1.71379844
129Facial cleft (HP:0002006)1.70936515
130Supernumerary spleens (HP:0009799)1.70374736
131Flat cornea (HP:0007720)1.69464029
132Generalized tonic-clonic seizures (HP:0002069)1.69376117
133Septo-optic dysplasia (HP:0100842)1.68979199
134Coronal craniosynostosis (HP:0004440)1.68663072
135Horseshoe kidney (HP:0000085)1.68189623
136Macroorchidism (HP:0000053)1.67246113
137Impulsivity (HP:0100710)1.66012005
138Abnormality of the astrocytes (HP:0100707)1.65744445
139Astrocytoma (HP:0009592)1.65744445
140Agitation (HP:0000713)1.65664615
141Micropenis (HP:0000054)1.65421597
142Insidious onset (HP:0003587)1.65324962
143Termporal pattern (HP:0011008)1.65324962
144Arnold-Chiari malformation (HP:0002308)1.65226159
145Hypoplastic female external genitalia (HP:0012815)1.65084074
146Short hallux (HP:0010109)1.64823061
147Bronchomalacia (HP:0002780)1.63668378
148Abnormality of the middle phalanges of the toes (HP:0010183)1.63096089
149Preaxial hand polydactyly (HP:0001177)1.62539580
150Aplasia/Hypoplasia of the hallux (HP:0008362)1.62472717
151Dialeptic seizures (HP:0011146)1.61857893
152Aplasia/Hypoplasia of the uvula (HP:0010293)1.61565728
153Abnormal eating behavior (HP:0100738)1.60777229
154Impaired smooth pursuit (HP:0007772)1.60128475
155Abnormal number of incisors (HP:0011064)1.57603492
156Aplasia/Hypoplasia of the sternum (HP:0006714)1.57408426
157Vertebral arch anomaly (HP:0008438)1.56584696
158Specific learning disability (HP:0001328)1.56021341
159Broad finger (HP:0001500)1.54930105
160Mutism (HP:0002300)1.54567848
161Narrow nasal bridge (HP:0000446)1.53651896
162Autism (HP:0000717)1.52634535
163Poor eye contact (HP:0000817)1.51101546
164Broad phalanges of the hand (HP:0009768)1.50802393
165Anomalous pulmonary venous return (HP:0010772)1.49456194
166Bowel diverticulosis (HP:0005222)1.49177274
167Postural instability (HP:0002172)1.48895274
168Abnormality of oral frenula (HP:0000190)1.48079703
169Amyotrophic lateral sclerosis (HP:0007354)1.47980463
170Abnormality of binocular vision (HP:0011514)1.47913338
171Diplopia (HP:0000651)1.47913338
172Pseudobulbar signs (HP:0002200)1.47471835
173Megalocornea (HP:0000485)1.47353082
174Anxiety (HP:0000739)1.46715039
175Abnormality of ocular smooth pursuit (HP:0000617)1.46706793

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.64442329
2MARK13.24787207
3EPHA42.93427819
4MAP3K92.89660330
5DDR22.74183822
6NTRK22.71775010
7TTK2.56055922
8MINK12.52085904
9KSR12.50563483
10MAP3K42.38404671
11TSSK62.29990791
12BUB12.28549142
13SRPK12.25520067
14TAF12.22952952
15PRKD32.21891263
16VRK22.18332002
17DYRK22.18217894
18PAK62.15165109
19TYRO31.91963484
20UHMK11.86375459
21LATS21.70529361
22KSR21.70354427
23PASK1.61495181
24PNCK1.60506387
25PLK41.52377672
26NTRK11.49368763
27EPHB21.48281362
28WEE11.46632036
29CAMK1D1.46003927
30SIK21.40435976
31SMG11.39326629
32ERBB31.37058683
33CAMKK11.32685359
34DAPK21.32152668
35MAP2K71.30769691
36ZAK1.29991274
37MAPK131.28563271
38MAP2K41.27378259
39DYRK31.25290185
40NEK11.23898506
41PDGFRA1.23221533
42PHKG21.21424708
43PHKG11.21424708
44PLK11.21323214
45CDK51.19824638
46TRIB31.14689859
47CHEK21.12100398
48STK381.09022718
49TRIM281.06905729
50VRK11.06538107
51CSNK1G11.03642178
52PAK31.03251890
53ATR1.02887177
54STK38L1.01880851
55ERBB21.01353448
56ALK1.00875657
57ICK1.00612439
58CAMK1G0.99747733
59NEK20.99524768
60CDK180.98719679
61CDK140.98416227
62TAOK10.98196145
63FGFR10.97033360
64LMTK20.96514266
65PLK20.96138823
66CDK150.95782874
67CDC70.93964613
68FGFR20.93898113
69TNIK0.91911875
70BRSK20.91310314
71MKNK10.90412339
72PRKCG0.88323871
73CDK11A0.84555454
74CSNK1G20.84304031
75BCR0.84075426
76NUAK10.82264669
77ATM0.81065913
78SGK2230.81032072
79SGK4940.81032072
80STK30.78041469
81CHEK10.77444532
82RIPK10.74103643
83LATS10.73587930
84DYRK1A0.72322385
85STK110.71432966
86STK160.71343092
87AURKB0.71050435
88RET0.69858756
89BRSK10.68598811
90PRKDC0.68043027
91CSNK1A1L0.67673288
92SGK20.67545514
93DAPK10.66955601
94PRKCH0.66805369
95CDK120.66611510
96MAP3K100.66534505
97CDK20.65512593
98BMX0.65445035
99DMPK0.64970628
100FER0.64666136
101NLK0.64584653
102CDK10.64044310
103CDC42BPA0.62978117
104PRPF4B0.62468254
105ROCK20.62459824
106MARK20.62237377
107PLK30.61236148
108SGK30.60060991
109BRD40.59801837
110CASK0.59330056
111MAPK100.58567566
112WNK10.58450483
113CDK70.58314510
114CSNK1G30.58263358
115SIK30.57917863
116NME10.57726012
117AURKA0.57239657
118PTK60.57167239
119DYRK1B0.55418069
120MAP3K20.53148167
121CSNK1E0.52444281
122RPS6KA20.52274758
123WNK30.51589144
124ROCK10.50712122
125PRKCZ0.50564291
126RPS6KA30.50300656
127TIE10.50178448
128CAMK2A0.48960606
129BRAF0.47702895
130SGK10.47187943
131EIF2AK20.47048877
132CDK190.47005141
133BMPR1B0.46342287
134MAPK90.46237466
135SIK10.45630022
136MAP3K120.45458376
137EEF2K0.44451485
138CAMK10.42619435
139CAMK40.42101403
140PTK20.42080856
141MKNK20.41561025
142PBK0.41344982
143GSK3B0.41205999
144CDK30.40677408
145STK40.38860094
146ERBB40.37162732
147STK240.37127871

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.24291651
2Mismatch repair_Homo sapiens_hsa034303.15545543
3Nicotine addiction_Homo sapiens_hsa050333.02409335
4Spliceosome_Homo sapiens_hsa030402.42367274
5GABAergic synapse_Homo sapiens_hsa047272.36436333
6Synaptic vesicle cycle_Homo sapiens_hsa047212.28811828
7Ribosome_Homo sapiens_hsa030102.27618028
8Non-homologous end-joining_Homo sapiens_hsa034502.26816450
9Circadian entrainment_Homo sapiens_hsa047132.17921722
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17439193
11Long-term potentiation_Homo sapiens_hsa047202.13106767
12Glutamatergic synapse_Homo sapiens_hsa047242.11772676
13RNA transport_Homo sapiens_hsa030132.08579332
14Base excision repair_Homo sapiens_hsa034102.02114069
15Olfactory transduction_Homo sapiens_hsa047402.01560413
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00495034
17Cell cycle_Homo sapiens_hsa041101.99977717
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99163002
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97410760
20Morphine addiction_Homo sapiens_hsa050321.90581098
21Amphetamine addiction_Homo sapiens_hsa050311.89510447
22Basal cell carcinoma_Homo sapiens_hsa052171.88155445
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.88103905
24Dopaminergic synapse_Homo sapiens_hsa047281.85948553
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.83549099
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72674880
27Axon guidance_Homo sapiens_hsa043601.72475483
28Homologous recombination_Homo sapiens_hsa034401.71768582
29RNA polymerase_Homo sapiens_hsa030201.67384007
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66164311
31Steroid biosynthesis_Homo sapiens_hsa001001.65709736
32Melanogenesis_Homo sapiens_hsa049161.65634168
33Fanconi anemia pathway_Homo sapiens_hsa034601.63627445
34Cocaine addiction_Homo sapiens_hsa050301.62390483
35Insulin secretion_Homo sapiens_hsa049111.60744388
36Gastric acid secretion_Homo sapiens_hsa049711.58170944
37Salivary secretion_Homo sapiens_hsa049701.58044745
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57518154
39Gap junction_Homo sapiens_hsa045401.57393519
40Cholinergic synapse_Homo sapiens_hsa047251.55620711
41Hedgehog signaling pathway_Homo sapiens_hsa043401.53595595
42Hippo signaling pathway_Homo sapiens_hsa043901.53291184
43Long-term depression_Homo sapiens_hsa047301.52501511
44Biosynthesis of amino acids_Homo sapiens_hsa012301.51182479
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48933767
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46063940
47Glioma_Homo sapiens_hsa052141.42903170
48Basal transcription factors_Homo sapiens_hsa030221.42133880
49Vitamin B6 metabolism_Homo sapiens_hsa007501.41819586
50One carbon pool by folate_Homo sapiens_hsa006701.41307013
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.41171169
52Selenocompound metabolism_Homo sapiens_hsa004501.40395369
53Nucleotide excision repair_Homo sapiens_hsa034201.40086418
54RNA degradation_Homo sapiens_hsa030181.39412114
55Wnt signaling pathway_Homo sapiens_hsa043101.34705002
56Taste transduction_Homo sapiens_hsa047421.34620966
57Oxytocin signaling pathway_Homo sapiens_hsa049211.33545563
58Dorso-ventral axis formation_Homo sapiens_hsa043201.33378997
59Oocyte meiosis_Homo sapiens_hsa041141.32135675
60Estrogen signaling pathway_Homo sapiens_hsa049151.30279889
61Renin secretion_Homo sapiens_hsa049241.27020677
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26748285
63GnRH signaling pathway_Homo sapiens_hsa049121.26352376
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25082001
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21801823
66Nitrogen metabolism_Homo sapiens_hsa009101.21088554
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19795175
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19280481
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17522291
70ErbB signaling pathway_Homo sapiens_hsa040121.17126433
71Lysine degradation_Homo sapiens_hsa003101.16557429
72Endometrial cancer_Homo sapiens_hsa052131.16323837
73Serotonergic synapse_Homo sapiens_hsa047261.11951202
74Colorectal cancer_Homo sapiens_hsa052101.09061594
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08863422
76Calcium signaling pathway_Homo sapiens_hsa040201.07924897
77Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07363344
78cAMP signaling pathway_Homo sapiens_hsa040241.07007548
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04596370
80Type II diabetes mellitus_Homo sapiens_hsa049301.03183545
81Pyruvate metabolism_Homo sapiens_hsa006201.03124794
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97898471
83Notch signaling pathway_Homo sapiens_hsa043300.97874536
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.97272306
85Propanoate metabolism_Homo sapiens_hsa006400.97020063
86mTOR signaling pathway_Homo sapiens_hsa041500.93327884
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91094066
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.90500547
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90369809
90Phototransduction_Homo sapiens_hsa047440.89632836
91mRNA surveillance pathway_Homo sapiens_hsa030150.89208614
92Protein export_Homo sapiens_hsa030600.85939677
93Alcoholism_Homo sapiens_hsa050340.85346516
94Huntingtons disease_Homo sapiens_hsa050160.83680804
95Non-small cell lung cancer_Homo sapiens_hsa052230.83203010
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82681322
97Carbon metabolism_Homo sapiens_hsa012000.82483803
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81267825
99Dilated cardiomyopathy_Homo sapiens_hsa054140.81162156
100Renal cell carcinoma_Homo sapiens_hsa052110.79914393
101Proteoglycans in cancer_Homo sapiens_hsa052050.79889061
102Rap1 signaling pathway_Homo sapiens_hsa040150.79476483
103Thyroid hormone synthesis_Homo sapiens_hsa049180.77769252
104Pyrimidine metabolism_Homo sapiens_hsa002400.77768815
105Choline metabolism in cancer_Homo sapiens_hsa052310.76705218
106Proteasome_Homo sapiens_hsa030500.75723033
107Tight junction_Homo sapiens_hsa045300.75700816
108Purine metabolism_Homo sapiens_hsa002300.74738062
109MAPK signaling pathway_Homo sapiens_hsa040100.74253069
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73974169
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72274908
112Parkinsons disease_Homo sapiens_hsa050120.70896099
113Chronic myeloid leukemia_Homo sapiens_hsa052200.70435732
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.69545792
115TGF-beta signaling pathway_Homo sapiens_hsa043500.69201670
116MicroRNAs in cancer_Homo sapiens_hsa052060.68642738
117Arginine and proline metabolism_Homo sapiens_hsa003300.68403076
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67594204
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66820802
120Adherens junction_Homo sapiens_hsa045200.66258144
121p53 signaling pathway_Homo sapiens_hsa041150.65658531
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62651802
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62255900
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61249119
125Glucagon signaling pathway_Homo sapiens_hsa049220.60684887
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60640367
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60311353
128Melanoma_Homo sapiens_hsa052180.59872797
129VEGF signaling pathway_Homo sapiens_hsa043700.59708183
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.59609137
131Bladder cancer_Homo sapiens_hsa052190.59358280
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59293968
133Ras signaling pathway_Homo sapiens_hsa040140.59287773
134Insulin signaling pathway_Homo sapiens_hsa049100.58955186
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58357843
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58098578
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53366932
138Folate biosynthesis_Homo sapiens_hsa007900.52651853
139Cardiac muscle contraction_Homo sapiens_hsa042600.51850926
140Pancreatic secretion_Homo sapiens_hsa049720.51074746
141Prion diseases_Homo sapiens_hsa050200.50070366
142Fatty acid elongation_Homo sapiens_hsa000620.49635134
143Focal adhesion_Homo sapiens_hsa045100.48093170
144Pathways in cancer_Homo sapiens_hsa052000.46664200
145beta-Alanine metabolism_Homo sapiens_hsa004100.45928321
146Fatty acid metabolism_Homo sapiens_hsa012120.45350477
147Thyroid cancer_Homo sapiens_hsa052160.45198599
148Endocytosis_Homo sapiens_hsa041440.44851706
149Vibrio cholerae infection_Homo sapiens_hsa051100.44751742
150Oxidative phosphorylation_Homo sapiens_hsa001900.44737127
151Sulfur relay system_Homo sapiens_hsa041220.38766426
152Prostate cancer_Homo sapiens_hsa052150.32979846
153Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32473332
154Alzheimers disease_Homo sapiens_hsa050100.31009324
155Metabolic pathways_Homo sapiens_hsa011000.30375938

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