SALL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.94803266
2lens fiber cell development (GO:0070307)5.28045461
3lung epithelium development (GO:0060428)5.09825255
4presynaptic membrane organization (GO:0097090)4.98637064
5neuronal stem cell maintenance (GO:0097150)4.89828069
6epithelial cell fate commitment (GO:0072148)4.83309445
7postsynaptic membrane organization (GO:0001941)4.82131910
8negative regulation of oligodendrocyte differentiation (GO:0048715)4.75283869
9epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.59114543
10mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.53933763
11axon ensheathment in central nervous system (GO:0032291)4.53424901
12central nervous system myelination (GO:0022010)4.53424901
13lateral sprouting from an epithelium (GO:0060601)4.48745855
14regulation of somitogenesis (GO:0014807)4.46930505
15negative regulation of astrocyte differentiation (GO:0048712)4.34813025
16Notch signaling involved in heart development (GO:0061314)4.27748917
17thalamus development (GO:0021794)4.27022371
18paraxial mesoderm development (GO:0048339)4.22622175
19endocardial cushion morphogenesis (GO:0003203)4.22243529
20collecting duct development (GO:0072044)4.19733404
21* negative regulation of smoothened signaling pathway (GO:0045879)4.17951309
22ventricular trabecula myocardium morphogenesis (GO:0003222)4.10614955
23embryonic camera-type eye development (GO:0031076)3.98977839
24heart valve formation (GO:0003188)3.96401284
25regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.96181599
26negative regulation of glial cell differentiation (GO:0045686)3.96010574
27negative regulation of translation, ncRNA-mediated (GO:0040033)3.94311615
28regulation of translation, ncRNA-mediated (GO:0045974)3.94311615
29negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.94311615
30tongue development (GO:0043586)3.89173424
31notochord development (GO:0030903)3.80041543
32neuron cell-cell adhesion (GO:0007158)3.74942202
33regulation of astrocyte differentiation (GO:0048710)3.62294962
34otic vesicle formation (GO:0030916)3.61372765
35chromatin remodeling at centromere (GO:0031055)3.60786656
36negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.57383904
37neuron fate commitment (GO:0048663)3.55851258
38heart trabecula morphogenesis (GO:0061384)3.54488593
39response to pheromone (GO:0019236)3.53069700
40somatic stem cell division (GO:0048103)3.50027507
41cochlea morphogenesis (GO:0090103)3.48570326
42planar cell polarity pathway involved in neural tube closure (GO:0090179)3.48409308
43L-serine metabolic process (GO:0006563)3.47495081
44outer ear morphogenesis (GO:0042473)3.43391636
45positive regulation of astrocyte differentiation (GO:0048711)3.41667596
46regulation of oligodendrocyte differentiation (GO:0048713)3.41194198
47CENP-A containing nucleosome assembly (GO:0034080)3.37888406
48mesenchyme morphogenesis (GO:0072132)3.33167239
49cell surface receptor signaling pathway involved in heart development (GO:0061311)3.32624820
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.31799379
51cellular response to cholesterol (GO:0071397)3.30002126
52somite development (GO:0061053)3.26990220
53DNA replication-dependent nucleosome organization (GO:0034723)3.24562729
54DNA replication-dependent nucleosome assembly (GO:0006335)3.24562729
55positive regulation of neuroblast proliferation (GO:0002052)3.22967715
56positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.22774857
57limb bud formation (GO:0060174)3.20830075
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.17698443
59negative regulation of gliogenesis (GO:0014014)3.16658453
60DNA replication-independent nucleosome organization (GO:0034724)3.15381040
61DNA replication-independent nucleosome assembly (GO:0006336)3.15381040
62cell migration involved in heart development (GO:0060973)3.15082903
63cell proliferation in forebrain (GO:0021846)3.14122498
64negative regulation of glial cell proliferation (GO:0060253)3.10918871
65epithelial cell differentiation involved in prostate gland development (GO:0060742)3.09950212
66radial glial cell differentiation (GO:0060019)3.08267793
67histone exchange (GO:0043486)3.07968912
68neuron fate determination (GO:0048664)3.07828938
69DNA damage response, detection of DNA damage (GO:0042769)3.05422390
70mechanosensory behavior (GO:0007638)3.04963498
71apoptotic process involved in morphogenesis (GO:0060561)3.03486021
72establishment of tissue polarity (GO:0007164)3.02543961
73establishment of planar polarity (GO:0001736)3.02543961
74negative regulation of chondrocyte differentiation (GO:0032331)3.02372498
75cerebral cortex radially oriented cell migration (GO:0021799)3.01839345
76generation of neurons (GO:0048699)3.01609555
77digestive tract morphogenesis (GO:0048546)3.00652436
78coronary vasculature morphogenesis (GO:0060977)2.97846056
79lens morphogenesis in camera-type eye (GO:0002089)2.94601684
80chondroitin sulfate catabolic process (GO:0030207)2.93969239
81establishment of integrated proviral latency (GO:0075713)2.93131386
82G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.93029102
83midbrain development (GO:0030901)2.92984949
84peptidyl-arginine omega-N-methylation (GO:0035247)2.92052350
85regulation of development, heterochronic (GO:0040034)2.91635925
86embryonic hindlimb morphogenesis (GO:0035116)2.90720627
87protein localization to kinetochore (GO:0034501)2.90431251
88negative regulation of epidermis development (GO:0045683)2.90148131
89negative regulation of myoblast differentiation (GO:0045662)2.89613483
90DNA double-strand break processing (GO:0000729)2.89449596
91head development (GO:0060322)2.88546124
92DNA replication checkpoint (GO:0000076)2.88514376
93negative regulation of transcription regulatory region DNA binding (GO:2000678)2.87774921
94RNA localization (GO:0006403)2.87536713
95* hindlimb morphogenesis (GO:0035137)2.87187014
96forebrain neuron differentiation (GO:0021879)2.86948183
97olfactory bulb development (GO:0021772)2.85679292
98vocalization behavior (GO:0071625)2.84707894
99regulation of non-canonical Wnt signaling pathway (GO:2000050)2.84677121
100histone arginine methylation (GO:0034969)2.83353258
101chondrocyte proliferation (GO:0035988)2.82928471
102regulation of posttranscriptional gene silencing (GO:0060147)2.82179493
103regulation of gene silencing by miRNA (GO:0060964)2.82179493
104regulation of gene silencing by RNA (GO:0060966)2.82179493
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.81786379
106regulation of nuclear cell cycle DNA replication (GO:0033262)2.81510827
107spinal cord development (GO:0021510)2.81328393
108regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.80953350
109positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.80596958
110renal system development (GO:0072001)2.79853745
111lung-associated mesenchyme development (GO:0060484)2.79595168
112nonmotile primary cilium assembly (GO:0035058)2.78552314
113regulation of glial cell proliferation (GO:0060251)2.78270343
114regulation of glial cell differentiation (GO:0045685)2.77939238
115ventricular septum morphogenesis (GO:0060412)2.77011608
116cell fate specification (GO:0001708)2.76523323
117cranial nerve development (GO:0021545)2.74766272
118mesenchymal to epithelial transition (GO:0060231)2.71211193
119inner ear receptor cell differentiation (GO:0060113)2.70104990
120axon extension involved in axon guidance (GO:0048846)2.69452269
121neuron projection extension involved in neuron projection guidance (GO:1902284)2.69452269
122dorsal/ventral neural tube patterning (GO:0021904)2.69417805
123dorsal/ventral axis specification (GO:0009950)2.69269316
124convergent extension (GO:0060026)2.69001137
125regulation of timing of cell differentiation (GO:0048505)2.68951525
126pre-miRNA processing (GO:0031054)2.68103738
127cell migration in hindbrain (GO:0021535)2.67494973
128trabecula morphogenesis (GO:0061383)2.66439826
129non-canonical Wnt signaling pathway (GO:0035567)2.65238785
130nephron tubule development (GO:0072080)2.64739248
131regulation of gliogenesis (GO:0014013)2.64682478
132stem cell division (GO:0017145)2.63818694
133Sertoli cell development (GO:0060009)2.63764543
134negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.62904401
135somite rostral/caudal axis specification (GO:0032525)2.61922937
136histone H4-K12 acetylation (GO:0043983)2.61594941
137cellular response to sterol (GO:0036315)2.58491910
138regulation of helicase activity (GO:0051095)2.58194610
139somatic stem cell maintenance (GO:0035019)2.57264969
140pyrimidine nucleobase catabolic process (GO:0006208)2.56289401
141mitotic metaphase plate congression (GO:0007080)2.55073260
142DNA strand elongation involved in DNA replication (GO:0006271)2.51357327
143DNA strand elongation (GO:0022616)2.48436928
144DNA ligation (GO:0006266)2.47183475
145C4-dicarboxylate transport (GO:0015740)2.46876221
146regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.46440955
147negative regulation of sister chromatid segregation (GO:0033046)2.46124994
148negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.46124994
149negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.46124994
150negative regulation of mitotic sister chromatid segregation (GO:0033048)2.46124994
151negative regulation of mitotic sister chromatid separation (GO:2000816)2.46124994
152eye photoreceptor cell differentiation (GO:0001754)2.42773406
153photoreceptor cell differentiation (GO:0046530)2.42773406
154regulation of mitotic spindle checkpoint (GO:1903504)2.41053122
155regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.41053122
156negative regulation of chromosome segregation (GO:0051985)2.40965702
157mitotic sister chromatid cohesion (GO:0007064)2.39392290
158ATP-dependent chromatin remodeling (GO:0043044)2.38817996
159negative regulation of mitosis (GO:0045839)2.38123772
160regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.33841253
161retinal ganglion cell axon guidance (GO:0031290)2.33823317
162pituitary gland development (GO:0021983)2.33264875
163replication fork processing (GO:0031297)2.33146538
164artery development (GO:0060840)2.32240731
165spindle checkpoint (GO:0031577)2.32108323
166dermatan sulfate biosynthetic process (GO:0030208)2.31822577
167appendage development (GO:0048736)2.31327362
168limb development (GO:0060173)2.31327362
169auditory behavior (GO:0031223)2.31094568
170oligodendrocyte differentiation (GO:0048709)2.30843076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.20211742
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.67525746
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.67525746
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.67525746
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.62138549
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.20540337
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.00579008
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.78875179
9SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.69069975
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.59624607
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.42743067
12* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.40747485
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.40085748
14* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.24628032
15GBX2_23144817_ChIP-Seq_PC3_Human2.24055752
16* EZH2_27304074_Chip-Seq_ESCs_Mouse2.22142248
17ZFP281_18757296_ChIP-ChIP_E14_Mouse2.20662503
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.17620316
19POU5F1_16518401_ChIP-PET_MESCs_Mouse2.13915748
20* CBX2_27304074_Chip-Seq_ESCs_Mouse2.13313849
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.10145612
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.09642093
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08135269
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.07642439
25* TP53_20018659_ChIP-ChIP_R1E_Mouse2.05164689
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03782839
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03483521
28NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.02737892
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00244797
30* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.97087192
31EWS_26573619_Chip-Seq_HEK293_Human1.96967329
32ZNF274_21170338_ChIP-Seq_K562_Hela1.94661752
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94159107
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.94137215
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.91787133
36* RING1B_27294783_Chip-Seq_NPCs_Mouse1.91573432
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.90364173
38SOX2_18555785_ChIP-Seq_MESCs_Mouse1.87840302
39* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.87011560
40FUS_26573619_Chip-Seq_HEK293_Human1.86240012
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84859128
42* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84826584
43* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84826584
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.83508112
45* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.83010734
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81485031
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80223790
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77917378
49EZH2_22144423_ChIP-Seq_EOC_Human1.77528036
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76308782
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75958972
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.75558259
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.73788361
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.72844578
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.72076356
56* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71789941
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69573762
58P300_19829295_ChIP-Seq_ESCs_Human1.68590720
59* RNF2_27304074_Chip-Seq_ESCs_Mouse1.68336381
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67711718
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67711718
62VDR_22108803_ChIP-Seq_LS180_Human1.65222002
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61612018
64* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59537007
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59163346
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59097130
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58756424
68* NANOG_16153702_ChIP-ChIP_HESCs_Human1.56358471
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56226719
70* RING1B_27294783_Chip-Seq_ESCs_Mouse1.55675936
71* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.54400646
72* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.49832729
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49000042
74IGF1R_20145208_ChIP-Seq_DFB_Human1.48050911
75AR_21572438_ChIP-Seq_LNCaP_Human1.47739005
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46336010
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40521008
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40050463
79* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.39624205
80* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.38675679
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36635687
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34790677
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.33846691
84* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33475690
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33136642
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.32311909
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.30820768
88TAF15_26573619_Chip-Seq_HEK293_Human1.28019179
89* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.27779732
90RNF2_27304074_Chip-Seq_NSC_Mouse1.25968215
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.25657345
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24694716
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24148652
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23987957
95* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23561110
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22974549
97* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.22677983
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22237595
99TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22162621
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.21042211
101* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.20827272
102PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.20475806
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20292555
104TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20032062
105MYC_18555785_ChIP-Seq_MESCs_Mouse1.19151626
106SOX9_26525672_Chip-Seq_HEART_Mouse1.18795416
107AR_21909140_ChIP-Seq_LNCAP_Human1.17925462
108* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17740002
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17466649
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16473250
111IRF1_19129219_ChIP-ChIP_H3396_Human1.16220141
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.15749870
113NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15254023
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15234479
115* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14752514
116* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13678055
117* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.12697366
118HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11942462
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11634224
120* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11347888
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11197209
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11178950
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10342192
124GABP_17652178_ChIP-ChIP_JURKAT_Human1.10245247
125MYC_18940864_ChIP-ChIP_HL60_Human1.10160283
126KDM2B_26808549_Chip-Seq_K562_Human1.10024237
127* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09566078
128* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09519550
129* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08636230
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08458513
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08453036
132ELK1_19687146_ChIP-ChIP_HELA_Human1.08412477
133* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07276561
134TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06825051
135MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06746865
136* EZH2_27294783_Chip-Seq_ESCs_Mouse1.06702184
137EGR1_19374776_ChIP-ChIP_THP-1_Human1.05339497
138* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03160507
139CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03115297
140* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.02869558
141* REST_21632747_ChIP-Seq_MESCs_Mouse1.01700253
142SMAD4_21799915_ChIP-Seq_A2780_Human1.01349627
143NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00285394
144* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99188902
145SALL1_21062744_ChIP-ChIP_HESCs_Human0.99103407
146SOX3_22085726_ChIP-Seq_NPCs_Mouse0.97387431
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.95084453
148XRN2_22483619_ChIP-Seq_HELA_Human0.93368052
149HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93016309
150SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92166683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.07347692
2MP0010030_abnormal_orbit_morphology4.55336079
3MP0002653_abnormal_ependyma_morphology3.56151223
4MP0000049_abnormal_middle_ear3.05392864
5MP0005423_abnormal_somatic_nervous3.02978080
6MP0003136_yellow_coat_color2.63583483
7MP0003880_abnormal_central_pattern2.50846961
8MP0000778_abnormal_nervous_system2.26980730
9MP0002102_abnormal_ear_morphology2.21395890
10MP0003283_abnormal_digestive_organ2.16029238
11MP0004858_abnormal_nervous_system2.13727278
12* MP0002249_abnormal_larynx_morphology2.12555679
13MP0001293_anophthalmia2.08166039
14MP0009780_abnormal_chondrocyte_physiolo2.02767080
15MP0008058_abnormal_DNA_repair2.01313558
16MP0002736_abnormal_nociception_after1.94958958
17MP0003938_abnormal_ear_development1.87670897
18MP0002751_abnormal_autonomic_nervous1.87307868
19MP0002089_abnormal_postnatal_growth/wei1.81251470
20MP0002938_white_spotting1.79718455
21MP0000428_abnormal_craniofacial_morphol1.76483223
22MP0008877_abnormal_DNA_methylation1.75698623
23MP0009053_abnormal_anal_canal1.73466935
24MP0003890_abnormal_embryonic-extraembry1.73277656
25MP0003937_abnormal_limbs/digits/tail_de1.73049798
26MP0004133_heterotaxia1.70308024
27MP0003941_abnormal_skin_development1.69270045
28MP0002282_abnormal_trachea_morphology1.65572163
29MP0001529_abnormal_vocalization1.63664533
30* MP0003755_abnormal_palate_morphology1.63117860
31MP0006292_abnormal_olfactory_placode1.62161164
32MP0003693_abnormal_embryo_hatching1.62077196
33MP0002092_abnormal_eye_morphology1.59841037
34MP0008932_abnormal_embryonic_tissue1.58682542
35MP0005257_abnormal_intraocular_pressure1.55139239
36MP0000579_abnormal_nail_morphology1.52987613
37MP0003861_abnormal_nervous_system1.52460570
38MP0000026_abnormal_inner_ear1.52128360
39MP0003122_maternal_imprinting1.50125716
40MP0002116_abnormal_craniofacial_bone1.49726428
41MP0004885_abnormal_endolymph1.47513675
42MP0009278_abnormal_bone_marrow1.46086634
43MP0008057_abnormal_DNA_replication1.44494317
44MP0003942_abnormal_urinary_system1.44245326
45MP0002233_abnormal_nose_morphology1.43838817
46MP0009250_abnormal_appendicular_skeleto1.43615957
47MP0001286_abnormal_eye_development1.43173444
48MP0003119_abnormal_digestive_system1.40391261
49MP0004134_abnormal_chest_morphology1.40309372
50MP0000534_abnormal_ureter_morphology1.39885727
51MP0003115_abnormal_respiratory_system1.39092845
52MP0003121_genomic_imprinting1.38417944
53MP0002085_abnormal_embryonic_tissue1.34009878
54MP0002932_abnormal_joint_morphology1.33829895
55MP0000432_abnormal_head_morphology1.32555443
56MP0002084_abnormal_developmental_patter1.32280769
57MP0005248_abnormal_Harderian_gland1.31715068
58MP0002111_abnormal_tail_morphology1.29656996
59MP0003935_abnormal_craniofacial_develop1.28852453
60MP0001968_abnormal_touch/_nociception1.28619367
61MP0000467_abnormal_esophagus_morphology1.28479234
62MP0002697_abnormal_eye_size1.26238045
63MP0003385_abnormal_body_wall1.26158172
64MP0001485_abnormal_pinna_reflex1.25600313
65MP0003111_abnormal_nucleus_morphology1.22267081
66MP0009672_abnormal_birth_weight1.21732018
67MP0005391_vision/eye_phenotype1.21577102
68MP0001177_atelectasis1.21410096
69MP0000631_abnormal_neuroendocrine_gland1.20135441
70MP0003718_maternal_effect1.15708836
71MP0003077_abnormal_cell_cycle1.14778226
72MP0004233_abnormal_muscle_weight1.11757056
73MP0001299_abnormal_eye_distance/1.11049681
74MP0001188_hyperpigmentation1.09020954
75MP0003787_abnormal_imprinting1.07357672
76MP0005499_abnormal_olfactory_system1.06746990
77MP0005394_taste/olfaction_phenotype1.06746990
78MP0005076_abnormal_cell_differentiation1.05792387
79MP0003635_abnormal_synaptic_transmissio1.04796767
80MP0000955_abnormal_spinal_cord1.04655798
81MP0003567_abnormal_fetal_cardiomyocyte1.04603814
82MP0001984_abnormal_olfaction1.03498122
83MP0005551_abnormal_eye_electrophysiolog1.03086583
84MP0008789_abnormal_olfactory_epithelium1.02655418
85MP0006072_abnormal_retinal_apoptosis1.02543666
86* MP0000762_abnormal_tongue_morphology1.02113345
87MP0003634_abnormal_glial_cell1.02032425
88MP0005377_hearing/vestibular/ear_phenot1.01651568
89MP0003878_abnormal_ear_physiology1.01651568
90MP0002152_abnormal_brain_morphology1.01566595
91MP0005508_abnormal_skeleton_morphology1.00926792
92MP0004859_abnormal_synaptic_plasticity1.00633466
93MP0002734_abnormal_mechanical_nocicepti0.99276429
94MP0001672_abnormal_embryogenesis/_devel0.98968335
95MP0005380_embryogenesis_phenotype0.98968335
96MP0000350_abnormal_cell_proliferation0.98327419
97MP0004270_analgesia0.98067219
98MP0004197_abnormal_fetal_growth/weight/0.96427451
99MP0005195_abnormal_posterior_eye0.95829350
100MP0005253_abnormal_eye_physiology0.95626961
101MP0001963_abnormal_hearing_physiology0.95625913
102MP0005171_absent_coat_pigmentation0.94370336
103MP0001346_abnormal_lacrimal_gland0.94083235
104MP0002638_abnormal_pupillary_reflex0.93809609
105MP0002114_abnormal_axial_skeleton0.92435526
106* MP0002752_abnormal_somatic_nervous0.90202983
107MP0001697_abnormal_embryo_size0.88591428
108MP0004381_abnormal_hair_follicle0.87702951
109* MP0002081_perinatal_lethality0.87700463
110MP0004742_abnormal_vestibular_system0.87149838
111MP0000537_abnormal_urethra_morphology0.86607319
112* MP0000163_abnormal_cartilage_morphology0.86459498
113MP0002272_abnormal_nervous_system0.86407673
114MP0005187_abnormal_penis_morphology0.86208525
115MP0003984_embryonic_growth_retardation0.85946254
116MP0006276_abnormal_autonomic_nervous0.85588492
117MP0008007_abnormal_cellular_replicative0.84178027
118MP0005646_abnormal_pituitary_gland0.84148870
119MP0002184_abnormal_innervation0.83680474
120MP0003011_delayed_dark_adaptation0.83679759
121MP0002557_abnormal_social/conspecific_i0.83633876
122MP0010307_abnormal_tumor_latency0.83425655
123MP0005623_abnormal_meninges_morphology0.83411378
124MP0002088_abnormal_embryonic_growth/wei0.83365244
125MP0002109_abnormal_limb_morphology0.82882852
126MP0009703_decreased_birth_body0.82485815
127MP0001486_abnormal_startle_reflex0.81032378
128MP0002882_abnormal_neuron_morphology0.79505719
129MP0000647_abnormal_sebaceous_gland0.79112481
130MP0002234_abnormal_pharynx_morphology0.77848321
131MP0004957_abnormal_blastocyst_morpholog0.76793975
132MP0010094_abnormal_chromosome_stability0.76448448
133MP0005197_abnormal_uvea_morphology0.74709591
134MP0001340_abnormal_eyelid_morphology0.74154237

Predicted human phenotypes

RankGene SetZ-score
1Partial duplication of thumb phalanx (HP:0009944)5.18060998
2Partial duplication of the phalanx of hand (HP:0009999)4.65900615
3Coronal craniosynostosis (HP:0004440)4.55468195
4Abnormality of the labia minora (HP:0012880)3.96215042
5Alacrima (HP:0000522)3.52298682
6Hepatoblastoma (HP:0002884)3.38009263
7Duplication of thumb phalanx (HP:0009942)3.37740929
8Neonatal short-limb short stature (HP:0008921)3.37690355
9Megalencephaly (HP:0001355)3.33943323
10Aplasia involving bones of the extremities (HP:0009825)3.30320373
11Aplasia involving bones of the upper limbs (HP:0009823)3.30320373
12Aplasia of the phalanges of the hand (HP:0009802)3.30320373
13Colon cancer (HP:0003003)3.27724412
14Aplasia involving forearm bones (HP:0009822)3.22256569
15Absent forearm bone (HP:0003953)3.22256569
16Preaxial foot polydactyly (HP:0001841)3.09919782
17Oligodactyly (HP:0012165)3.06092146
18Rib fusion (HP:0000902)2.98374904
19Adactyly (HP:0009776)2.97902890
20Bilateral microphthalmos (HP:0007633)2.95919602
21Abnormality of the antihelix (HP:0009738)2.88619643
22Absent radius (HP:0003974)2.83027212
23Decreased lacrimation (HP:0000633)2.82224163
24Rectovaginal fistula (HP:0000143)2.78822759
25Rectal fistula (HP:0100590)2.78822759
26Absent septum pellucidum (HP:0001331)2.76418992
27Oligodactyly (hands) (HP:0001180)2.72398688
28Intestinal atresia (HP:0011100)2.67446797
29Anophthalmia (HP:0000528)2.67438576
30Abnormal number of incisors (HP:0011064)2.64264049
31Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.63114737
32Split foot (HP:0001839)2.59364461
33High anterior hairline (HP:0009890)2.58653097
34Optic nerve hypoplasia (HP:0000609)2.57959665
35Septo-optic dysplasia (HP:0100842)2.55350960
36Abnormality of the diencephalon (HP:0010662)2.53466262
37Medulloblastoma (HP:0002885)2.52761954
38Intestinal fistula (HP:0100819)2.52584127
39Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.50970215
40Abnormal lung lobation (HP:0002101)2.48986800
41Skull defect (HP:0001362)2.45548920
42Esophageal atresia (HP:0002032)2.45257651
43Abnormality of the middle phalanges of the toes (HP:0010183)2.44810573
44Increased nuchal translucency (HP:0010880)2.44660975
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.42441435
46Short 4th metacarpal (HP:0010044)2.42441435
47Nasolacrimal duct obstruction (HP:0000579)2.39353715
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.37556474
49Abnormality of the septum pellucidum (HP:0007375)2.36922210
50Uterine leiomyosarcoma (HP:0002891)2.35029832
51Leiomyosarcoma (HP:0100243)2.35029832
52Hemivertebrae (HP:0002937)2.35013660
53Mixed hearing impairment (HP:0000410)2.34732310
54Broad toe (HP:0001837)2.32179924
55Supernumerary spleens (HP:0009799)2.31107971
56Abnormality of the salivary glands (HP:0010286)2.30719285
57Gastrointestinal atresia (HP:0002589)2.30672296
58Abnormality of the lacrimal duct (HP:0011481)2.30453477
59Arnold-Chiari malformation (HP:0002308)2.30123744
60Vaginal fistula (HP:0004320)2.30102186
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29810346
62Broad hallux (HP:0010055)2.28592880
63Ectopic anus (HP:0004397)2.27144891
64Trigonocephaly (HP:0000243)2.23363840
65Renal hypoplasia (HP:0000089)2.22456874
66Maternal diabetes (HP:0009800)2.21852625
67Ectopic kidney (HP:0000086)2.18424456
68Bifid scrotum (HP:0000048)2.17884982
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.16759284
70Meckel diverticulum (HP:0002245)2.16305290
71Cutaneous finger syndactyly (HP:0010554)2.15744065
72Synostosis of carpal bones (HP:0005048)2.14631782
73Abnormality of the incisor (HP:0000676)2.13876120
74Cortical dysplasia (HP:0002539)2.13792693
75Aplasia cutis congenita (HP:0001057)2.12142635
76True hermaphroditism (HP:0010459)2.10078029
77Split hand (HP:0001171)2.10052119
78Birth length less than 3rd percentile (HP:0003561)2.09743447
79Thickened helices (HP:0000391)2.08963459
80Neoplasm of the oral cavity (HP:0100649)2.08384490
81Glioma (HP:0009733)2.07630601
82Hemiparesis (HP:0001269)2.06775776
83Abnormality of the 4th metacarpal (HP:0010012)2.06307957
84Chromsome breakage (HP:0040012)2.05552492
85Concave nail (HP:0001598)2.03814273
86Abnormality of the ileum (HP:0001549)2.03430896
87Increased number of teeth (HP:0011069)2.02632529
88Aplasia/Hypoplasia of the ulna (HP:0006495)2.01664845
89Preaxial hand polydactyly (HP:0001177)2.01243412
90Cutaneous syndactyly (HP:0012725)2.01011270
91Preauricular skin tag (HP:0000384)1.99516383
92Abnormality of the nasolacrimal system (HP:0000614)1.98920345
93Shawl scrotum (HP:0000049)1.98668361
94Heterotopia (HP:0002282)1.98410814
95Nephroblastoma (Wilms tumor) (HP:0002667)1.97272750
96Midline defect of the nose (HP:0004122)1.96722646
97Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.96721234
98Morphological abnormality of the inner ear (HP:0011390)1.96218615
99Synostosis involving the elbow (HP:0003938)1.96214205
100Humeroradial synostosis (HP:0003041)1.96214205
101Broad alveolar ridges (HP:0000187)1.95990963
102Choanal stenosis (HP:0000452)1.94171532
103Hamartoma (HP:0010566)1.92852494
104Gastrointestinal carcinoma (HP:0002672)1.92441920
105Malignant gastrointestinal tract tumors (HP:0006749)1.92441920
106Ependymoma (HP:0002888)1.92371668
107Astrocytoma (HP:0009592)1.92207513
108Abnormality of the astrocytes (HP:0100707)1.92207513
109Recurrent corneal erosions (HP:0000495)1.92056837
110Aplasia/Hypoplasia of the uvula (HP:0010293)1.91860328
111Atresia of the external auditory canal (HP:0000413)1.90754043
112Hypoplasia of the ulna (HP:0003022)1.89498002
113Volvulus (HP:0002580)1.88824480
114Skin tags (HP:0010609)1.88093154
115Genital tract atresia (HP:0001827)1.87368625
116Facial hemangioma (HP:0000329)1.86702085
117Abnormality of chromosome stability (HP:0003220)1.86594665
118Embryonal renal neoplasm (HP:0011794)1.86485480
119Absent toe (HP:0010760)1.86420674
120Transitional cell carcinoma of the bladder (HP:0006740)1.86030864
121Aqueductal stenosis (HP:0002410)1.85559565
122Pseudobulbar signs (HP:0002200)1.85219881
123Vaginal atresia (HP:0000148)1.85196401
124Hypoplasia of the radius (HP:0002984)1.85105397
125Fibular hypoplasia (HP:0003038)1.84705317
126Broad thumb (HP:0011304)1.83968811
127Carpal synostosis (HP:0009702)1.83811436
128Triphalangeal thumb (HP:0001199)1.83102557
129Hyperglycinemia (HP:0002154)1.82316835
130Abnormality of incisor morphology (HP:0011063)1.82181544
131Down-sloping shoulders (HP:0200021)1.81841239
132Stenosis of the external auditory canal (HP:0000402)1.81806608
133Large earlobe (HP:0009748)1.81702180
134Abnormality of the pubic bones (HP:0003172)1.81185476
135Spastic diplegia (HP:0001264)1.80647504
136Anal stenosis (HP:0002025)1.80499502
137Overfolded helix (HP:0000396)1.79847511
138Bronchomalacia (HP:0002780)1.79043166
139Holoprosencephaly (HP:0001360)1.78536346
140Bifid tongue (HP:0010297)1.78284766
141Hyperventilation (HP:0002883)1.77375433
142Molar tooth sign on MRI (HP:0002419)1.76110216
143Abnormality of midbrain morphology (HP:0002418)1.76110216
144Abnormality of the metopic suture (HP:0005556)1.75117092
145Nephronophthisis (HP:0000090)1.74173679
1462-3 toe syndactyly (HP:0004691)1.74150444
147Sex reversal (HP:0012245)1.74025199
148Abnormal sex determination (HP:0012244)1.74025199
149Renal duplication (HP:0000075)1.73916248
150Sclerocornea (HP:0000647)1.73875586
151Median cleft lip (HP:0000161)1.72333020
152Pancreatic fibrosis (HP:0100732)1.71897323
153Short hallux (HP:0010109)1.69950941
154Impulsivity (HP:0100710)1.68634391
155Broad foot (HP:0001769)1.63881211
156Hyperglycinuria (HP:0003108)1.63207342
157Embryonal neoplasm (HP:0002898)1.62564499
158Drooling (HP:0002307)1.62460318
159Abnormality of glycine metabolism (HP:0010895)1.61548387
160Abnormality of serine family amino acid metabolism (HP:0010894)1.61548387
161Postaxial hand polydactyly (HP:0001162)1.61277278

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.11769087
2ICK3.31426705
3CDK122.95428630
4EPHB22.93926414
5WNK32.62488708
6MAPK152.58190318
7FGFR32.16687796
8TYRO32.15959580
9NTRK22.14463221
10DDR22.13203944
11MAP3K102.07518150
12UHMK12.07429799
13CASK2.02795968
14PLK41.93830578
15VRK21.83247741
16TGFBR21.76894703
17EEF2K1.75592398
18BRSK21.75073773
19PLK31.73418316
20MKNK21.67063354
21PDGFRA1.65647168
22MKNK11.62430256
23MAP4K21.57955222
24INSRR1.54943924
25TAF11.54230755
26PAK41.53007027
27KSR11.51462066
28FGFR21.48837609
29CDK81.48040065
30BRD41.43010196
31NUAK11.42845197
32BMPR1B1.42675091
33CDC71.41102928
34YES11.33072616
35ERBB21.32731011
36NEK21.29440756
37ZAK1.26567690
38FGFR11.25748116
39DYRK1B1.25545749
40PBK1.23246477
41SIK11.20355582
42ERBB41.20257963
43MAP3K41.19081623
44CSNK1G11.18465458
45STK38L1.16591277
46TTK1.16314186
47TLK11.15494765
48MATK1.13265896
49DYRK21.13098253
50MAPK131.11116740
51CDK71.10389222
52MARK11.09190579
53PRKD31.08854506
54NME11.08705919
55LATS21.08076289
56CSF1R1.07226602
57CSNK1G21.06726923
58PLK11.05852208
59MTOR1.04607730
60DYRK31.04208355
61TRIM281.03069316
62NLK1.01135450
63LMTK20.91549523
64FGR0.91445682
65BRSK10.91420461
66CDK180.90108178
67STK390.90091413
68PHKG10.88583071
69PHKG20.88583071
70CHEK20.88580674
71CDK150.88435283
72CSNK1G30.86596344
73AKT20.84954917
74CDK11A0.83200637
75TNIK0.81631749
76CDK60.81625421
77PNCK0.81621868
78SRPK10.80432970
79PLK20.79497148
80EPHA40.79091603
81PRKCZ0.77228391
82GRK70.75383290
83CDK140.72251083
84PKN10.71202991
85CSNK1A1L0.70967415
86TESK20.70282348
87TGFBR10.70166825
88DMPK0.69483769
89CHEK10.68521159
90ALK0.68483706
91IRAK20.67853069
92NTRK30.67555082
93BMX0.66741052
94PAK20.66633578
95NTRK10.66401097
96CDK20.65711984
97MELK0.65306175
98VRK10.64839600
99CAMK1G0.63658988
100DYRK1A0.63446893
101GRK10.63155931
102WNK40.62684044
103MOS0.62358382
104ATM0.61703793
105STK100.61613316
106MAP3K60.60222322
107MAP3K90.59951979
108CDK10.59557895
109ROCK20.59137531
110GSK3A0.58648196
111SGK2230.58455941
112SGK4940.58455941
113PRKCG0.57925985
114CDK30.57796640
115BCR0.56217623
116ACVR1B0.55982456
117RPS6KA40.55533998
118ATR0.55033367
119ROCK10.54108118
120CDK40.52358214
121TSSK60.52238477
122RPS6KB20.52138668
123AURKA0.51794042
124PAK60.50968041
125MAPK90.50959727
126MAP2K70.50818711
127SGK20.50401347
128MAPK70.49621664
129LATS10.48432602
130EIF2AK20.48251140
131CAMK1D0.47086036
132MAPKAPK50.46253703
133WEE10.45508449
134PRKDC0.45472259
135PDGFRB0.44961153
136MAPK100.44463359
137IGF1R0.43856427
138GRK50.43418614
139CSNK1E0.42182848
140CAMK40.41934472
141NEK10.39849507
142PRKD20.38795631
143PASK0.37920046
144AURKB0.37740735
145CDK190.36761107
146OXSR10.36597192
147STK30.34782674
148PRKCE0.31927904
149RPS6KA50.31833198
150PINK10.30055678
151CSNK1D0.29460388

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.46856837
2Notch signaling pathway_Homo sapiens_hsa043303.86060450
3Hedgehog signaling pathway_Homo sapiens_hsa043403.53459278
4Hippo signaling pathway_Homo sapiens_hsa043902.73547885
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.66604989
6Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.56741147
7Spliceosome_Homo sapiens_hsa030402.51290471
8Dorso-ventral axis formation_Homo sapiens_hsa043202.38584799
9Mismatch repair_Homo sapiens_hsa034302.36630329
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31531446
11DNA replication_Homo sapiens_hsa030302.27592234
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.18009524
13mRNA surveillance pathway_Homo sapiens_hsa030152.16022109
14Non-homologous end-joining_Homo sapiens_hsa034502.14716397
15Nitrogen metabolism_Homo sapiens_hsa009102.14409487
16MicroRNAs in cancer_Homo sapiens_hsa052062.11452336
17Wnt signaling pathway_Homo sapiens_hsa043102.11172056
18Bladder cancer_Homo sapiens_hsa052191.95923958
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.94627538
20Cell cycle_Homo sapiens_hsa041101.85026251
21RNA polymerase_Homo sapiens_hsa030201.84947103
22Axon guidance_Homo sapiens_hsa043601.75062669
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.74878650
24Nicotine addiction_Homo sapiens_hsa050331.71601092
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.70739967
26Base excision repair_Homo sapiens_hsa034101.70631063
27Colorectal cancer_Homo sapiens_hsa052101.68966672
28Fanconi anemia pathway_Homo sapiens_hsa034601.61005861
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.60792374
30Melanogenesis_Homo sapiens_hsa049161.57800377
31Fatty acid biosynthesis_Homo sapiens_hsa000611.56799939
32Vitamin B6 metabolism_Homo sapiens_hsa007501.54278590
33TGF-beta signaling pathway_Homo sapiens_hsa043501.54034950
34Protein export_Homo sapiens_hsa030601.50959835
35Prion diseases_Homo sapiens_hsa050201.48516661
36Adherens junction_Homo sapiens_hsa045201.47732317
37Propanoate metabolism_Homo sapiens_hsa006401.46788557
38RNA transport_Homo sapiens_hsa030131.44150750
39Proteasome_Homo sapiens_hsa030501.38176517
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34964411
41Lysine degradation_Homo sapiens_hsa003101.31007208
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30944240
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27587681
44Pathways in cancer_Homo sapiens_hsa052001.19779324
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19079139
46Gap junction_Homo sapiens_hsa045401.14792455
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13222217
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.12377467
49Phototransduction_Homo sapiens_hsa047441.10570070
50Butanoate metabolism_Homo sapiens_hsa006501.05262658
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04262616
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02660209
53HTLV-I infection_Homo sapiens_hsa051661.01552910
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01122250
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00372777
56Proteoglycans in cancer_Homo sapiens_hsa052050.99812214
57Chronic myeloid leukemia_Homo sapiens_hsa052200.98884273
58Huntingtons disease_Homo sapiens_hsa050160.98709538
59Parkinsons disease_Homo sapiens_hsa050120.97702579
60Oocyte meiosis_Homo sapiens_hsa041140.96754796
61mTOR signaling pathway_Homo sapiens_hsa041500.96114222
62Endometrial cancer_Homo sapiens_hsa052130.93436183
63Melanoma_Homo sapiens_hsa052180.89309459
64Glioma_Homo sapiens_hsa052140.88408946
65Nucleotide excision repair_Homo sapiens_hsa034200.88342649
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87403333
67Selenocompound metabolism_Homo sapiens_hsa004500.87305304
68Cardiac muscle contraction_Homo sapiens_hsa042600.86860381
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.86411270
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85567954
71ErbB signaling pathway_Homo sapiens_hsa040120.85559611
72Cocaine addiction_Homo sapiens_hsa050300.85109089
73Rap1 signaling pathway_Homo sapiens_hsa040150.84572971
74Tight junction_Homo sapiens_hsa045300.84159490
75Pyruvate metabolism_Homo sapiens_hsa006200.81203460
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80871770
77Purine metabolism_Homo sapiens_hsa002300.78298516
78Choline metabolism in cancer_Homo sapiens_hsa052310.76437867
79Oxidative phosphorylation_Homo sapiens_hsa001900.76243369
80One carbon pool by folate_Homo sapiens_hsa006700.75988051
81Pancreatic cancer_Homo sapiens_hsa052120.75800142
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74048171
83p53 signaling pathway_Homo sapiens_hsa041150.72190013
84Taste transduction_Homo sapiens_hsa047420.70102675
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69947029
86Renal cell carcinoma_Homo sapiens_hsa052110.68441849
87GABAergic synapse_Homo sapiens_hsa047270.67546451
88Folate biosynthesis_Homo sapiens_hsa007900.67410499
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66105007
90Non-small cell lung cancer_Homo sapiens_hsa052230.65886765
91Viral myocarditis_Homo sapiens_hsa054160.64563602
92Homologous recombination_Homo sapiens_hsa034400.63924763
93Pyrimidine metabolism_Homo sapiens_hsa002400.62834904
94Prostate cancer_Homo sapiens_hsa052150.62773627
95beta-Alanine metabolism_Homo sapiens_hsa004100.62154974
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61787205
97RNA degradation_Homo sapiens_hsa030180.60497193
98Amphetamine addiction_Homo sapiens_hsa050310.60204008
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.58470971
100Thyroid cancer_Homo sapiens_hsa052160.57983035
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.57272980
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57239294
103Morphine addiction_Homo sapiens_hsa050320.55863339
104Basal transcription factors_Homo sapiens_hsa030220.54989388
105Small cell lung cancer_Homo sapiens_hsa052220.53327989
106AMPK signaling pathway_Homo sapiens_hsa041520.53184526
107Circadian entrainment_Homo sapiens_hsa047130.52809925
108Glutathione metabolism_Homo sapiens_hsa004800.51773467
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50463727
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49721661
111MAPK signaling pathway_Homo sapiens_hsa040100.49623789
112Long-term depression_Homo sapiens_hsa047300.49357872
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48987391
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48934725
115Fatty acid elongation_Homo sapiens_hsa000620.48622593
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48101239
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47886830
118Ras signaling pathway_Homo sapiens_hsa040140.46233713
119Dopaminergic synapse_Homo sapiens_hsa047280.45855252
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44042990
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43756158
122Arginine and proline metabolism_Homo sapiens_hsa003300.43206527
123Peroxisome_Homo sapiens_hsa041460.43037096
124Estrogen signaling pathway_Homo sapiens_hsa049150.42412414
125Alzheimers disease_Homo sapiens_hsa050100.42215983
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41808319
127cAMP signaling pathway_Homo sapiens_hsa040240.41610221
128Retinol metabolism_Homo sapiens_hsa008300.38073599
129Ribosome_Homo sapiens_hsa030100.37422261
130Focal adhesion_Homo sapiens_hsa045100.35998244
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34253661
132Linoleic acid metabolism_Homo sapiens_hsa005910.34110962
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33991491
134Steroid biosynthesis_Homo sapiens_hsa001000.33970527
135Glutamatergic synapse_Homo sapiens_hsa047240.33710287
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33576467
137Olfactory transduction_Homo sapiens_hsa047400.33476006
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32719926
139Serotonergic synapse_Homo sapiens_hsa047260.32090936
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31802442
141GnRH signaling pathway_Homo sapiens_hsa049120.30890320
142Viral carcinogenesis_Homo sapiens_hsa052030.29053060
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28980489
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.25964584
145Biosynthesis of amino acids_Homo sapiens_hsa012300.25401406
146Fatty acid metabolism_Homo sapiens_hsa012120.25053050
147Dilated cardiomyopathy_Homo sapiens_hsa054140.24524260
148Alcoholism_Homo sapiens_hsa050340.23199368
149Oxytocin signaling pathway_Homo sapiens_hsa049210.23052517
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22933261
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22106236
152Endocytosis_Homo sapiens_hsa041440.21152681

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