SALL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger transcription factor thought to play a role in the development of abducens motor neurons. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in labyrinthine layer morphogenesis (GO:0060670)5.56363407
2regulation of gene silencing by RNA (GO:0060966)5.32838646
3regulation of posttranscriptional gene silencing (GO:0060147)5.32838646
4regulation of gene silencing by miRNA (GO:0060964)5.32838646
5nuclear pore organization (GO:0006999)5.30054628
6nuclear pore complex assembly (GO:0051292)4.93326974
7lung-associated mesenchyme development (GO:0060484)4.90370104
8mitotic metaphase plate congression (GO:0007080)4.90327360
9anterior/posterior axis specification, embryo (GO:0008595)4.89879235
10negative regulation of telomerase activity (GO:0051974)4.78184781
11IMP biosynthetic process (GO:0006188)4.69624860
12nucleobase biosynthetic process (GO:0046112)4.48026906
13DNA replication initiation (GO:0006270)4.45817339
14DNA replication checkpoint (GO:0000076)4.44973343
15spindle assembly involved in mitosis (GO:0090307)4.39784657
16protein localization to kinetochore (GO:0034501)4.30729357
17DNA replication-dependent nucleosome organization (GO:0034723)4.27785222
18DNA replication-dependent nucleosome assembly (GO:0006335)4.27785222
19purine nucleobase biosynthetic process (GO:0009113)4.27551519
20metaphase plate congression (GO:0051310)4.24447378
21mitotic nuclear envelope disassembly (GO:0007077)4.20465186
22ribosome biogenesis (GO:0042254)4.11380021
23ribosome assembly (GO:0042255)4.06618254
24protein K6-linked ubiquitination (GO:0085020)4.06191675
25IMP metabolic process (GO:0046040)4.03418467
26DNA strand elongation involved in DNA replication (GO:0006271)4.01342382
27establishment of integrated proviral latency (GO:0075713)3.98088341
28nuclear envelope disassembly (GO:0051081)3.90744322
29membrane disassembly (GO:0030397)3.90744322
30chromatin remodeling at centromere (GO:0031055)3.89254751
31kinetochore organization (GO:0051383)3.86030515
32DNA unwinding involved in DNA replication (GO:0006268)3.80986440
33DNA strand elongation (GO:0022616)3.80885374
34CENP-A containing nucleosome assembly (GO:0034080)3.75749812
35pore complex assembly (GO:0046931)3.75175233
36attachment of spindle microtubules to kinetochore (GO:0008608)3.74981477
37pre-miRNA processing (GO:0031054)3.73344584
38negative regulation of translation, ncRNA-mediated (GO:0040033)3.73177106
39regulation of translation, ncRNA-mediated (GO:0045974)3.73177106
40negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.73177106
41mitotic sister chromatid segregation (GO:0000070)3.72079932
42formation of translation preinitiation complex (GO:0001731)3.71970083
43L-serine metabolic process (GO:0006563)3.71774367
44kinetochore assembly (GO:0051382)3.67143489
45telomere maintenance via semi-conservative replication (GO:0032201)3.65083833
46establishment of chromosome localization (GO:0051303)3.64460911
47paraxial mesoderm development (GO:0048339)3.64308043
48protein localization to chromosome, centromeric region (GO:0071459)3.60332535
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.57717831
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.57717831
51synapsis (GO:0007129)3.56246515
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.56191571
53positive regulation of chromosome segregation (GO:0051984)3.53998802
54negative regulation of chromosome segregation (GO:0051985)3.50731286
55DNA replication-independent nucleosome organization (GO:0034724)3.50505282
56DNA replication-independent nucleosome assembly (GO:0006336)3.50505282
57regulation of spindle organization (GO:0090224)3.50249413
58regulation of nuclear cell cycle DNA replication (GO:0033262)3.48732799
59meiotic chromosome segregation (GO:0045132)3.46899792
60regulation of helicase activity (GO:0051095)3.45622664
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.44414071
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44280738
63microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.42377408
64negative regulation of mitotic sister chromatid segregation (GO:0033048)3.41372165
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.41372165
66negative regulation of sister chromatid segregation (GO:0033046)3.41372165
67negative regulation of mitotic sister chromatid separation (GO:2000816)3.41372165
68histone H4-K12 acetylation (GO:0043983)3.41246479
69spindle checkpoint (GO:0031577)3.39766102
70folic acid-containing compound biosynthetic process (GO:0009396)3.39485419
71mitotic chromosome condensation (GO:0007076)3.39466945
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.37627411
73histone exchange (GO:0043486)3.37353466
74DNA double-strand break processing (GO:0000729)3.36667907
75regulation of histone H3-K9 methylation (GO:0051570)3.35468571
76regulation of telomerase activity (GO:0051972)3.33450657
77ribonucleoprotein complex biogenesis (GO:0022613)3.32813253
78negative regulation of histone methylation (GO:0031061)3.32395691
79mitotic spindle checkpoint (GO:0071174)3.32394091
80heterochromatin organization (GO:0070828)3.32301273
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32272776
82regulation of mitotic spindle checkpoint (GO:1903504)3.32272776
83maturation of SSU-rRNA (GO:0030490)3.32050703
84telomere maintenance via recombination (GO:0000722)3.31930530
85regulation of mesoderm development (GO:2000380)3.31928113
86mitotic spindle assembly checkpoint (GO:0007094)3.29253182
87spindle assembly checkpoint (GO:0071173)3.28863331
88regulation of mitotic metaphase/anaphase transition (GO:0030071)3.28803518
89serine family amino acid catabolic process (GO:0009071)3.27441295
90rRNA modification (GO:0000154)3.26632363
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.26195496
92glycine metabolic process (GO:0006544)3.23692590
93mitotic recombination (GO:0006312)3.23515049
94regulation of chromosome segregation (GO:0051983)3.23478840
95telomere maintenance via telomere lengthening (GO:0010833)3.20610475
96regulation of sister chromatid segregation (GO:0033045)3.19413439
97regulation of mitotic sister chromatid separation (GO:0010965)3.19413439
98regulation of mitotic sister chromatid segregation (GO:0033047)3.19413439
99regulation of centrosome cycle (GO:0046605)3.19305480
100sister chromatid segregation (GO:0000819)3.16410257
101maturation of 5.8S rRNA (GO:0000460)3.15710614
102regulation of gene silencing (GO:0060968)3.13566340
103regulation of mitotic spindle organization (GO:0060236)3.10261052
104regulation of cell fate specification (GO:0042659)3.09298508
105regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06798968
106positive regulation of mitotic sister chromatid separation (GO:1901970)3.06403493
107positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06403493
108positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06403493
109histone arginine methylation (GO:0034969)3.06107364
110regulation of centriole replication (GO:0046599)3.05712759
111transcription from RNA polymerase I promoter (GO:0006360)3.03937932
112DNA duplex unwinding (GO:0032508)3.03286463
113regulation of telomere maintenance via telomerase (GO:0032210)3.03150389
114DNA geometric change (GO:0032392)3.02645027
115spliceosomal snRNP assembly (GO:0000387)2.98645107
116nuclear envelope organization (GO:0006998)2.98477247
117transcription-coupled nucleotide-excision repair (GO:0006283)2.96984843
118exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96221807
119chromatin assembly or disassembly (GO:0006333)2.94676385
120ATP-dependent chromatin remodeling (GO:0043044)2.94401678
121female gonad development (GO:0008585)2.94390837
122nucleotide-excision repair, DNA gap filling (GO:0006297)2.94265167
123rRNA processing (GO:0006364)2.93443160
124mismatch repair (GO:0006298)2.92802217
125replication fork processing (GO:0031297)2.91191095
126establishment of viral latency (GO:0019043)2.89595635
127DNA strand renaturation (GO:0000733)2.89120686
128mitotic G2/M transition checkpoint (GO:0044818)2.87401849
129somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85538960
130somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85538960
131isotype switching (GO:0045190)2.85538960
132lateral sprouting from an epithelium (GO:0060601)2.84143299
133positive regulation of SMAD protein import into nucleus (GO:0060391)2.84070560
134nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83381341
135DNA ligation (GO:0006266)2.83061354
136single strand break repair (GO:0000012)2.82964717
137organ growth (GO:0035265)2.79174689
138somatic recombination of immunoglobulin gene segments (GO:0016447)2.77692342
139protein complex localization (GO:0031503)2.75369419
140somite development (GO:0061053)2.73260834
141regulation of DNA methylation (GO:0044030)2.71952526
142mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71538443
143mitochondrial respiratory chain complex I assembly (GO:0032981)2.71538443
144NADH dehydrogenase complex assembly (GO:0010257)2.71538443
145non-recombinational repair (GO:0000726)2.67910768
146double-strand break repair via nonhomologous end joining (GO:0006303)2.67910768
147maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66842916
148nodal signaling pathway (GO:0038092)2.66756164
149L-alpha-amino acid transmembrane transport (GO:1902475)2.64336610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.53525073
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.20654576
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.06449229
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.61624716
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.21903611
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10896630
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89877981
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85635492
9POU5F1_16153702_ChIP-ChIP_HESCs_Human2.82808738
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77599655
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73662881
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.73630662
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.73630662
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.73630662
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68016720
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61285746
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.52739471
18NANOG_18555785_ChIP-Seq_MESCs_Mouse2.45906484
19* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.43451706
20* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.42202901
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41773649
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.40864603
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39224172
24SOX2_16153702_ChIP-ChIP_HESCs_Human2.37162774
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36379088
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.33727133
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31183117
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.27090753
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23216383
30AR_21909140_ChIP-Seq_LNCAP_Human2.20619184
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.17099951
32GABP_17652178_ChIP-ChIP_JURKAT_Human2.13343640
33SALL1_21062744_ChIP-ChIP_HESCs_Human2.05618978
34XRN2_22483619_ChIP-Seq_HELA_Human2.05244092
35* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.04908608
36MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02470627
37* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.97913464
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96496209
39* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95587311
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.92998916
41ZNF274_21170338_ChIP-Seq_K562_Hela1.89829442
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.87313534
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.86484779
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.81472243
45FUS_26573619_Chip-Seq_HEK293_Human1.80326465
46VDR_23849224_ChIP-Seq_CD4+_Human1.73676020
47* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70820246
48IRF1_19129219_ChIP-ChIP_H3396_Human1.66891369
49* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.64106882
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63947582
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.63586877
52EWS_26573619_Chip-Seq_HEK293_Human1.63048517
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61973881
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60066756
55TTF2_22483619_ChIP-Seq_HELA_Human1.58301683
56DCP1A_22483619_ChIP-Seq_HELA_Human1.57715707
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.57580336
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54997546
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.54586363
60GABP_19822575_ChIP-Seq_HepG2_Human1.51881609
61* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51390733
62FOXP3_21729870_ChIP-Seq_TREG_Human1.50326738
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46792088
64* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.45203735
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44799192
66* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.43640883
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37738155
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36817485
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34360010
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34024641
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33541679
72* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33342787
73* TP63_19390658_ChIP-ChIP_HaCaT_Human1.33121643
74* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30307467
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.29721455
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29327026
77* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28768191
78SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27735540
79KDM5A_27292631_Chip-Seq_BREAST_Human1.26792234
80P300_19829295_ChIP-Seq_ESCs_Human1.25733687
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21615729
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.21497134
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20167027
84CIITA_25753668_ChIP-Seq_RAJI_Human1.19922463
85ELK1_19687146_ChIP-ChIP_HELA_Human1.19126196
86* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17798815
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16508918
88* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15948743
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.15148156
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14741601
91VDR_22108803_ChIP-Seq_LS180_Human1.13328895
92* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13124697
93NANOG_18692474_ChIP-Seq_MEFs_Mouse1.12766294
94* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12282775
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10365186
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09571133
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08925627
98* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07752990
99* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06913608
100* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06422794
101POU5F1_16518401_ChIP-PET_MESCs_Mouse1.06283598
102* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02650748
103LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99123934
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98936143
105* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97129270
106* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97014127
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.96371164
108* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95535452
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95439842
110SRF_21415370_ChIP-Seq_HL-1_Mouse0.94806111
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94286437
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94134366
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94093596
114HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93650409
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92286540
116MYC_18940864_ChIP-ChIP_HL60_Human0.89699762
117MYC_22102868_ChIP-Seq_BL_Human0.89449749
118* KAP1_27257070_Chip-Seq_ESCs_Mouse0.89427843
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88604149
120TFEB_21752829_ChIP-Seq_HELA_Human0.88198945
121* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88075982
122TAF15_26573619_Chip-Seq_HEK293_Human0.87490979
123RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87437300
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86278421
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85288198
126IGF1R_20145208_ChIP-Seq_DFB_Human0.81983989
127GBX2_23144817_ChIP-Seq_PC3_Human0.81581964
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80122679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.48282408
2MP0003111_abnormal_nucleus_morphology4.43192355
3* MP0003693_abnormal_embryo_hatching4.25627433
4* MP0004957_abnormal_blastocyst_morpholog4.22121063
5MP0008057_abnormal_DNA_replication4.17001388
6MP0003077_abnormal_cell_cycle3.79672644
7MP0008877_abnormal_DNA_methylation3.35968960
8MP0003123_paternal_imprinting3.29754930
9MP0008058_abnormal_DNA_repair3.26461575
10* MP0001730_embryonic_growth_arrest2.64281269
11MP0008007_abnormal_cellular_replicative2.61986414
12* MP0008932_abnormal_embryonic_tissue2.59053555
13MP0002254_reproductive_system_inflammat2.58506244
14MP0003806_abnormal_nucleotide_metabolis2.51677446
15MP0003718_maternal_effect2.50089475
16MP0003890_abnormal_embryonic-extraembry2.44452161
17* MP0000350_abnormal_cell_proliferation2.36012682
18MP0010352_gastrointestinal_tract_polyps2.34961447
19MP0003786_premature_aging2.33468185
20MP0005380_embryogenesis_phenotype2.22020407
21MP0001672_abnormal_embryogenesis/_devel2.22020407
22MP0002653_abnormal_ependyma_morphology2.21305413
23MP0004133_heterotaxia2.11513432
24* MP0002085_abnormal_embryonic_tissue2.02298885
25MP0005670_abnormal_white_adipose2.01330482
26* MP0001697_abnormal_embryo_size1.98880248
27* MP0002084_abnormal_developmental_patter1.97344277
28MP0003984_embryonic_growth_retardation1.89420081
29MP0002938_white_spotting1.87745855
30MP0002088_abnormal_embryonic_growth/wei1.85611865
31MP0010030_abnormal_orbit_morphology1.84176022
32MP0003121_genomic_imprinting1.82963783
33MP0006292_abnormal_olfactory_placode1.82270841
34MP0004197_abnormal_fetal_growth/weight/1.82105762
35MP0002102_abnormal_ear_morphology1.71824849
36MP0002210_abnormal_sex_determination1.68364818
37MP0001293_anophthalmia1.65482386
38* MP0003119_abnormal_digestive_system1.65089224
39* MP0002086_abnormal_extraembryonic_tissu1.63195769
40* MP0002080_prenatal_lethality1.62855757
41MP0003941_abnormal_skin_development1.59819389
42* MP0000049_abnormal_middle_ear1.57248327
43MP0001188_hyperpigmentation1.54014874
44MP0010307_abnormal_tumor_latency1.53106220
45MP0003567_abnormal_fetal_cardiomyocyte1.47791259
46MP0001145_abnormal_male_reproductive1.45493395
47MP0002233_abnormal_nose_morphology1.43920907
48MP0009053_abnormal_anal_canal1.38650387
49MP0001929_abnormal_gametogenesis1.34045568
50MP0005076_abnormal_cell_differentiation1.32130733
51MP0003787_abnormal_imprinting1.31473298
52MP0000653_abnormal_sex_gland1.30199371
53MP0001661_extended_life_span1.29572663
54MP0000313_abnormal_cell_death1.28063271
55MP0009672_abnormal_birth_weight1.25702039
56MP0005377_hearing/vestibular/ear_phenot1.23120332
57MP0003878_abnormal_ear_physiology1.23120332
58MP0003122_maternal_imprinting1.19556357
59MP0003283_abnormal_digestive_organ1.18702541
60MP0000631_abnormal_neuroendocrine_gland1.18120179
61MP0004185_abnormal_adipocyte_glucose1.12632204
62MP0002160_abnormal_reproductive_system1.12145278
63* MP0003937_abnormal_limbs/digits/tail_de1.08139542
64MP0006072_abnormal_retinal_apoptosis1.07195153
65MP0009703_decreased_birth_body1.06715284
66MP0001299_abnormal_eye_distance/1.06674631
67* MP0002111_abnormal_tail_morphology1.02687192
68* MP0001119_abnormal_female_reproductive1.02427459
69MP0000537_abnormal_urethra_morphology1.01762448
70MP0000566_synostosis1.01760376
71MP0001177_atelectasis1.01405916
72MP0002019_abnormal_tumor_incidence0.98182960
73MP0001286_abnormal_eye_development0.95613775
74MP0000490_abnormal_crypts_of0.92869555
75MP0005266_abnormal_metabolism0.92402483
76MP0000432_abnormal_head_morphology0.92011933
77MP0003186_abnormal_redox_activity0.90336318
78MP0003136_yellow_coat_color0.90141901
79* MP0003861_abnormal_nervous_system0.90129695
80MP0002282_abnormal_trachea_morphology0.87373621
81MP0005389_reproductive_system_phenotype0.86757471
82* MP0002751_abnormal_autonomic_nervous0.86713592
83MP0008770_decreased_survivor_rate0.84341900
84MP0005395_other_phenotype0.83932514
85* MP0001485_abnormal_pinna_reflex0.83242313
86MP0003698_abnormal_male_reproductive0.80942930
87MP0002092_abnormal_eye_morphology0.80807813
88MP0003942_abnormal_urinary_system0.80158559
89MP0003699_abnormal_female_reproductive0.79817442
90MP0005646_abnormal_pituitary_gland0.79329154
91MP0000647_abnormal_sebaceous_gland0.78870345
92MP0000383_abnormal_hair_follicle0.78610388
93MP0002697_abnormal_eye_size0.78226658
94MP0002736_abnormal_nociception_after0.77509061
95* MP0003936_abnormal_reproductive_system0.76324186
96MP0003566_abnormal_cell_adhesion0.76171481
97MP0002249_abnormal_larynx_morphology0.75741392
98MP0005391_vision/eye_phenotype0.75565095
99MP0009384_cardiac_valve_regurgitation0.75260439
100MP0002161_abnormal_fertility/fecundity0.74801812
101MP0009250_abnormal_appendicular_skeleto0.74445864
102MP0008995_early_reproductive_senescence0.74314938
103MP0000579_abnormal_nail_morphology0.74029029
104* MP0005384_cellular_phenotype0.73895530
105MP0003705_abnormal_hypodermis_morpholog0.73575209
106MP0004264_abnormal_extraembryonic_tissu0.71550744
107MP0003115_abnormal_respiratory_system0.71134052
108MP0002269_muscular_atrophy0.70431616
109MP0000778_abnormal_nervous_system0.69803776
110MP0001915_intracranial_hemorrhage0.69582771
111MP0000358_abnormal_cell_content/0.69022194
112MP0003755_abnormal_palate_morphology0.68645106
113MP0002127_abnormal_cardiovascular_syste0.67908805
114MP0005195_abnormal_posterior_eye0.67334138
115MP0000428_abnormal_craniofacial_morphol0.66099288
116MP0003935_abnormal_craniofacial_develop0.65804748
117MP0001529_abnormal_vocalization0.65333556
118MP0003221_abnormal_cardiomyocyte_apopto0.64510826
119* MP0002116_abnormal_craniofacial_bone0.64406109
120MP0008789_abnormal_olfactory_epithelium0.64348185
121MP0005023_abnormal_wound_healing0.63822224
122MP0005501_abnormal_skin_physiology0.63706832
123MP0002114_abnormal_axial_skeleton0.62550664
124* MP0005621_abnormal_cell_physiology0.61658339
125MP0002396_abnormal_hematopoietic_system0.61066269
126MP0003938_abnormal_ear_development0.59186916
127MP0001919_abnormal_reproductive_system0.56220794
128MP0006035_abnormal_mitochondrial_morpho0.56120777
129MP0003950_abnormal_plasma_membrane0.54857854
130MP0005499_abnormal_olfactory_system0.53258001
131MP0005394_taste/olfaction_phenotype0.53258001
132* MP0002925_abnormal_cardiovascular_devel0.53125038
133MP0005623_abnormal_meninges_morphology0.52530278
134* MP0003315_abnormal_perineum_morphology0.51393879

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.68585035
2Breast hypoplasia (HP:0003187)5.14253883
3Abnormality of the labia minora (HP:0012880)4.71267385
4Ependymoma (HP:0002888)4.34332602
5Chromsome breakage (HP:0040012)4.10978977
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.09168075
7Impulsivity (HP:0100710)3.97673511
8Patellar aplasia (HP:0006443)3.95812074
9Degeneration of anterior horn cells (HP:0002398)3.93919498
10Abnormality of the anterior horn cell (HP:0006802)3.93919498
11Supernumerary spleens (HP:0009799)3.87671006
12Aplasia/Hypoplasia of the patella (HP:0006498)3.79137714
13Septo-optic dysplasia (HP:0100842)3.58841865
14Medulloblastoma (HP:0002885)3.57695306
15Maternal diabetes (HP:0009800)3.56436109
16* Absent radius (HP:0003974)3.45977528
17Colon cancer (HP:0003003)3.29471040
18* Aplasia involving forearm bones (HP:0009822)3.24346796
19* Absent forearm bone (HP:0003953)3.24346796
20Shawl scrotum (HP:0000049)3.19558252
21Selective tooth agenesis (HP:0001592)3.18620555
22Meckel diverticulum (HP:0002245)3.18446091
23Rhabdomyosarcoma (HP:0002859)3.10762376
24Abnormality of the ileum (HP:0001549)3.02415488
25Abnormality of the renal collecting system (HP:0004742)3.02291237
26Abnormality of the astrocytes (HP:0100707)3.00964271
27Astrocytoma (HP:0009592)3.00964271
28Abnormality of the parathyroid morphology (HP:0011766)2.98625850
29Abnormality of chromosome stability (HP:0003220)2.97165998
30Rib fusion (HP:0000902)2.93536577
31Oral leukoplakia (HP:0002745)2.92882949
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.92504853
33Abnormality of abdominal situs (HP:0011620)2.90462572
34Abdominal situs inversus (HP:0003363)2.90462572
35Abnormality of the preputium (HP:0100587)2.85261866
36* Ectopic kidney (HP:0000086)2.83831232
37Cerebral hypomyelination (HP:0006808)2.80453816
38Agnosia (HP:0010524)2.79669380
39Bilateral microphthalmos (HP:0007633)2.78031064
40Pendular nystagmus (HP:0012043)2.77328480
41Abnormality of DNA repair (HP:0003254)2.74178765
42Neoplasm of the oral cavity (HP:0100649)2.72725418
43Glioma (HP:0009733)2.71586026
44Breast aplasia (HP:0100783)2.68657787
45Anophthalmia (HP:0000528)2.63335116
46Rough bone trabeculation (HP:0100670)2.60647364
47Small intestinal stenosis (HP:0012848)2.55013782
48Duodenal stenosis (HP:0100867)2.55013782
49Duplication of thumb phalanx (HP:0009942)2.51149865
50Premature ovarian failure (HP:0008209)2.49697622
51Aplasia/Hypoplasia of the breasts (HP:0010311)2.49653623
52Reticulocytopenia (HP:0001896)2.48645645
53Neoplasm of striated muscle (HP:0009728)2.48629225
54Abnormal lung lobation (HP:0002101)2.47959536
55Aplasia/Hypoplasia of the sternum (HP:0006714)2.47949126
56Spinal muscular atrophy (HP:0007269)2.47205231
57* Aplasia/hypoplasia of the humerus (HP:0006507)2.46890551
58Atrophy/Degeneration involving motor neurons (HP:0007373)2.43084354
59Osteomalacia (HP:0002749)2.38180294
60Abnormality of the duodenum (HP:0002246)2.37835583
61Abnormal number of incisors (HP:0011064)2.36134510
62Absent septum pellucidum (HP:0001331)2.30211590
63Missing ribs (HP:0000921)2.30151580
64Hepatoblastoma (HP:0002884)2.27971802
65Biliary tract neoplasm (HP:0100574)2.27744184
66Hyperglycinemia (HP:0002154)2.26304109
67Tracheoesophageal fistula (HP:0002575)2.25450703
68Neoplasm of the pancreas (HP:0002894)2.24055345
69* Absent thumb (HP:0009777)2.23776153
70High anterior hairline (HP:0009890)2.23724467
71Proximal placement of thumb (HP:0009623)2.22922424
72Abnormality of the middle phalanges of the toes (HP:0010183)2.21821442
73Facial hemangioma (HP:0000329)2.18627747
74Esophageal atresia (HP:0002032)2.18566439
75Abnormality of the septum pellucidum (HP:0007375)2.18359590
76Abnormality of pyrimidine metabolism (HP:0004353)2.17111946
77Deviation of the thumb (HP:0009603)2.17004612
78Duplicated collecting system (HP:0000081)2.16575080
79Bone marrow hypocellularity (HP:0005528)2.15703039
80* Carpal bone hypoplasia (HP:0001498)2.11927818
81Nephroblastoma (Wilms tumor) (HP:0002667)2.11289020
82Sloping forehead (HP:0000340)2.09591901
83Atresia of the external auditory canal (HP:0000413)2.08294548
84Vitreoretinal degeneration (HP:0000655)2.07828459
85Myelodysplasia (HP:0002863)2.06890324
86Aqueductal stenosis (HP:0002410)2.06312931
87Bifid tongue (HP:0010297)2.04670310
88Acute necrotizing encephalopathy (HP:0006965)2.04628431
89Trismus (HP:0000211)2.04162611
90* Horseshoe kidney (HP:0000085)2.03876390
91Premature graying of hair (HP:0002216)2.03849737
92* Short humerus (HP:0005792)2.03802615
93Intestinal atresia (HP:0011100)2.00751870
94Embryonal renal neoplasm (HP:0011794)1.99931209
95Abnormality of cochlea (HP:0000375)1.99452365
96Clubbing of toes (HP:0100760)1.96849985
97Abnormality of serum amino acid levels (HP:0003112)1.96275948
98Cafe-au-lait spot (HP:0000957)1.96145005
99Abnormal trabecular bone morphology (HP:0100671)1.95222931
100Abnormality of the salivary glands (HP:0010286)1.94629824
101Oligomenorrhea (HP:0000876)1.94379557
102Acute encephalopathy (HP:0006846)1.93575772
103Secondary amenorrhea (HP:0000869)1.93164252
104Cutaneous finger syndactyly (HP:0010554)1.91291932
105Asplenia (HP:0001746)1.91175039
106Abnormality of glycine metabolism (HP:0010895)1.90673703
107Abnormality of serine family amino acid metabolism (HP:0010894)1.90673703
108Hemivertebrae (HP:0002937)1.90622272
109Hyperglycinuria (HP:0003108)1.90261061
110Supernumerary bones of the axial skeleton (HP:0009144)1.89637566
111Gastrointestinal atresia (HP:0002589)1.89585467
112Synostosis involving the elbow (HP:0003938)1.88753566
113Humeroradial synostosis (HP:0003041)1.88753566
114Abnormal biliary tract morphology (HP:0012440)1.88368967
115Abnormality of the carotid arteries (HP:0005344)1.88234237
116Cellular immunodeficiency (HP:0005374)1.86402762
117* Triphalangeal thumb (HP:0001199)1.86308016
118Basal cell carcinoma (HP:0002671)1.86194866
11911 pairs of ribs (HP:0000878)1.84795160
120Multiple enchondromatosis (HP:0005701)1.84221479
121Abnormality of the nasal septum (HP:0000419)1.84131239
122Cutaneous syndactyly (HP:0012725)1.83781989
123Spastic diplegia (HP:0001264)1.83452838
124Aplasia/Hypoplasia of the spleen (HP:0010451)1.83353027
125Oligodactyly (HP:0012165)1.82234598
126Tongue fasciculations (HP:0001308)1.81462575
127Optic nerve hypoplasia (HP:0000609)1.81441106
128Neoplasm of the colon (HP:0100273)1.80922380
129* Short hallux (HP:0010109)1.80619423
130Methylmalonic acidemia (HP:0002912)1.80478796
131Ovarian neoplasm (HP:0100615)1.80466602
132Neoplasm of the adrenal cortex (HP:0100641)1.79836077
133Abolished electroretinogram (ERG) (HP:0000550)1.79816729
134Homocystinuria (HP:0002156)1.79710985
135Abnormality of homocysteine metabolism (HP:0010919)1.79710985
136* Short thumb (HP:0009778)1.79153105
137Gastrointestinal carcinoma (HP:0002672)1.78271988
138Malignant gastrointestinal tract tumors (HP:0006749)1.78271988
139Abnormality of the proximal phalanges of the hand (HP:0009834)1.76988902
140Supernumerary ribs (HP:0005815)1.76423154
141Sex reversal (HP:0012245)1.75651280
142Abnormal sex determination (HP:0012244)1.75651280
143Ureteral duplication (HP:0000073)1.75521169
144Gonadotropin excess (HP:0000837)1.73714767
145* Aplasia/Hypoplasia of the hallux (HP:0008362)1.71374096
146Abnormality of the phalanges of the 5th finger (HP:0004213)1.69948808
147Broad thumb (HP:0011304)1.69903604
148Hypoplastic female external genitalia (HP:0012815)1.69358383
149Hypoalphalipoproteinemia (HP:0003233)1.68688915
150Myelomeningocele (HP:0002475)1.65593722
151* Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65338376
152Morphological abnormality of the middle ear (HP:0008609)1.64983289
153Abnormal mitochondria in muscle tissue (HP:0008316)1.63976889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.23958938
2BUB14.15998185
3CDC73.83519764
4CDK123.73998864
5SRPK13.19548871
6TTK3.00296625
7EPHA22.87736130
8EIF2AK12.85445550
9NEK12.74328589
10VRK22.60864850
11PLK42.52494832
12NEK22.45612194
13TNIK2.45133076
14TAF12.39053904
15PLK12.31119431
16TSSK62.18151617
17NUAK12.14945012
18TRIM282.13694779
19BRSK22.11240829
20PLK32.07097970
21PNCK2.06683197
22AKT31.97625820
23STK38L1.97386618
24GRK11.83489554
25CHEK21.82408238
26MKNK11.80367407
27BMPR1B1.79935589
28LATS21.79445785
29CDK71.75876746
30MKNK21.72442687
31ACVR1B1.64508823
32CDK191.56597003
33EIF2AK31.55184243
34ATR1.51876881
35AURKB1.50036371
36PASK1.48899523
37RPS6KB21.44406479
38AURKA1.43087926
39CHEK11.42579803
40CDK91.39807292
41BRD41.34947008
42VRK11.34320304
43ZAK1.31055053
44MST41.29442208
45ALK1.26955300
46FGFR21.26907320
47MAP3K81.26231754
48TESK21.23422382
49BRSK11.22796495
50CDK41.20415696
51TLK11.14683586
52BRAF1.11996935
53DYRK31.08603631
54CDK21.06737237
55STK41.05248744
56ATM1.05117633
57PBK1.03177171
58NME11.02023482
59NLK1.00051567
60STK100.99097127
61MELK0.98529791
62CSNK1G10.98493509
63OXSR10.93624683
64CASK0.91137321
65PRKCI0.82633713
66NEK60.82318387
67MAP4K20.78282043
68PINK10.77542862
69LATS10.76839819
70PAK40.76407381
71EIF2AK20.76375309
72CDK10.76135035
73MAP3K40.74914113
74TIE10.70800710
75CSNK2A20.70420440
76STK30.68602452
77CSNK1G20.67876721
78CSNK1E0.65951816
79EPHA40.65826762
80CSNK2A10.65772255
81MTOR0.62715750
82PDK30.61814408
83PDK40.61814408
84CDK60.61577364
85CSNK1G30.61105823
86DYRK20.59768473
87RPS6KA40.58423365
88STK160.58082981
89PAK10.57918627
90PIM10.54031288
91SMG10.53099532
92INSRR0.52398130
93ERBB40.52261459
94FRK0.50819539
95PDK20.50139950
96CAMK1G0.49437739
97ADRBK20.48069852
98CSNK1A1L0.47473090
99CSNK1A10.45458781
100MET0.45251037
101PRKCG0.44612105
102CSNK1D0.44258971
103PRKDC0.43320125
104STK240.42430483
105SCYL20.41116662
106AKT20.41050739
107CAMK1D0.39303387
108MAPK140.38807228
109TGFBR10.38591745
110CLK10.37099039
111ICK0.36982211
112NME20.36384146
113BCR0.34631232
114PLK20.33762743
115PRKCE0.32625573
116GSK3B0.32062802
117STK390.31201530
118CDK30.30094742
119MAP2K70.29976461
120WNK40.28979248
121WNK30.28662662
122RPS6KA50.28660889
123EEF2K0.28555483
124FLT30.27779301
125CDK80.27722581
126AKT10.26360351
127FGFR10.25636321
128TESK10.23187410
129MAPK10.22985109
130MARK30.21552044
131MAPKAPK30.21420656
132MAPK100.20346901
133MAP3K90.16233918
134KSR10.15262351
135BCKDK0.14702008
136MAP3K100.14670298
137CCNB10.14133583

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.49138884
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.46765421
3Mismatch repair_Homo sapiens_hsa034304.45238424
4RNA polymerase_Homo sapiens_hsa030203.70890823
5RNA transport_Homo sapiens_hsa030133.59954403
6Spliceosome_Homo sapiens_hsa030403.25973182
7Homologous recombination_Homo sapiens_hsa034403.12180088
8One carbon pool by folate_Homo sapiens_hsa006703.03358196
9Proteasome_Homo sapiens_hsa030502.93596000
10Cell cycle_Homo sapiens_hsa041102.90390379
11Nucleotide excision repair_Homo sapiens_hsa034202.83497330
12Base excision repair_Homo sapiens_hsa034102.74952078
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71629186
14Fanconi anemia pathway_Homo sapiens_hsa034602.46872055
15Basal transcription factors_Homo sapiens_hsa030222.43688715
16Pyrimidine metabolism_Homo sapiens_hsa002402.36125808
17Ribosome_Homo sapiens_hsa030102.25153788
18mRNA surveillance pathway_Homo sapiens_hsa030152.16738930
19RNA degradation_Homo sapiens_hsa030182.05301570
20Non-homologous end-joining_Homo sapiens_hsa034501.92911283
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86224267
22p53 signaling pathway_Homo sapiens_hsa041151.51497343
23Steroid biosynthesis_Homo sapiens_hsa001001.50018447
24Oocyte meiosis_Homo sapiens_hsa041141.40150802
25Purine metabolism_Homo sapiens_hsa002301.37548508
26Protein export_Homo sapiens_hsa030601.35823046
27Propanoate metabolism_Homo sapiens_hsa006401.32793184
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28630673
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22783128
30Pyruvate metabolism_Homo sapiens_hsa006201.19089341
31Vitamin B6 metabolism_Homo sapiens_hsa007501.18110840
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.17820712
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08111350
34Biosynthesis of amino acids_Homo sapiens_hsa012301.07999754
35Selenocompound metabolism_Homo sapiens_hsa004501.05869331
36Epstein-Barr virus infection_Homo sapiens_hsa051691.04667738
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02556990
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02545361
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01966617
40Systemic lupus erythematosus_Homo sapiens_hsa053220.98976080
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96052424
42Hippo signaling pathway_Homo sapiens_hsa043900.95502653
43Vitamin digestion and absorption_Homo sapiens_hsa049770.94558039
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91870106
45Parkinsons disease_Homo sapiens_hsa050120.89519010
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87690479
47Basal cell carcinoma_Homo sapiens_hsa052170.87552237
48Thyroid cancer_Homo sapiens_hsa052160.86418497
49Oxidative phosphorylation_Homo sapiens_hsa001900.85286724
50Phototransduction_Homo sapiens_hsa047440.85210254
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.85110313
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.82627085
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79296973
54Renin-angiotensin system_Homo sapiens_hsa046140.75905581
55Folate biosynthesis_Homo sapiens_hsa007900.73609850
56Fatty acid elongation_Homo sapiens_hsa000620.73499724
57Viral carcinogenesis_Homo sapiens_hsa052030.72941846
58TGF-beta signaling pathway_Homo sapiens_hsa043500.70790567
59MicroRNAs in cancer_Homo sapiens_hsa052060.70595281
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68438303
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66311585
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.65849829
63Fructose and mannose metabolism_Homo sapiens_hsa000510.64887187
64Hedgehog signaling pathway_Homo sapiens_hsa043400.64398452
65Herpes simplex infection_Homo sapiens_hsa051680.63116936
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62853194
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60759028
68Nitrogen metabolism_Homo sapiens_hsa009100.59966787
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59497257
70HTLV-I infection_Homo sapiens_hsa051660.56968974
71Nicotine addiction_Homo sapiens_hsa050330.56747997
72Carbon metabolism_Homo sapiens_hsa012000.56367587
73Sulfur metabolism_Homo sapiens_hsa009200.55251587
74Retinol metabolism_Homo sapiens_hsa008300.53902076
75Pentose phosphate pathway_Homo sapiens_hsa000300.53746624
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53072821
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51602915
78Adherens junction_Homo sapiens_hsa045200.51347325
79Huntingtons disease_Homo sapiens_hsa050160.51309230
80beta-Alanine metabolism_Homo sapiens_hsa004100.50952851
81Glutathione metabolism_Homo sapiens_hsa004800.50697755
82Notch signaling pathway_Homo sapiens_hsa043300.50619391
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49890283
84Alzheimers disease_Homo sapiens_hsa050100.49508142
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49236561
86Tight junction_Homo sapiens_hsa045300.48956265
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48523636
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47632259
89Linoleic acid metabolism_Homo sapiens_hsa005910.44158579
90Fat digestion and absorption_Homo sapiens_hsa049750.42258271
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41787468
92Arachidonic acid metabolism_Homo sapiens_hsa005900.41659026
93Caffeine metabolism_Homo sapiens_hsa002320.40563362
94Tryptophan metabolism_Homo sapiens_hsa003800.39896328
95Antigen processing and presentation_Homo sapiens_hsa046120.38594232
96Melanogenesis_Homo sapiens_hsa049160.35839429
97Taste transduction_Homo sapiens_hsa047420.34930299
98Peroxisome_Homo sapiens_hsa041460.34364113
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.33446951
100Butanoate metabolism_Homo sapiens_hsa006500.33273177
101Galactose metabolism_Homo sapiens_hsa000520.32254259
102Wnt signaling pathway_Homo sapiens_hsa043100.32073427
103Alcoholism_Homo sapiens_hsa050340.31594769
104Axon guidance_Homo sapiens_hsa043600.31126255
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29429803
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29191779
107Arginine and proline metabolism_Homo sapiens_hsa003300.28378539
108Lysine degradation_Homo sapiens_hsa003100.28087787
109Small cell lung cancer_Homo sapiens_hsa052220.27155793
110Fatty acid degradation_Homo sapiens_hsa000710.26967469
111mTOR signaling pathway_Homo sapiens_hsa041500.26931243
112Pathways in cancer_Homo sapiens_hsa052000.25971738
113Chemical carcinogenesis_Homo sapiens_hsa052040.25249400
114Metabolic pathways_Homo sapiens_hsa011000.23706355
115Colorectal cancer_Homo sapiens_hsa052100.20826583
116HIF-1 signaling pathway_Homo sapiens_hsa040660.20623542
117Bladder cancer_Homo sapiens_hsa052190.20587840
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20324985
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20156306
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.14245626
121Melanoma_Homo sapiens_hsa052180.13449998
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13143358
123Regulation of autophagy_Homo sapiens_hsa041400.12106027
124Prostate cancer_Homo sapiens_hsa052150.10924374
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10902878
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10597436
127FoxO signaling pathway_Homo sapiens_hsa040680.05219353
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03603983
129Sulfur relay system_Homo sapiens_hsa041220.02542333
130Phenylalanine metabolism_Homo sapiens_hsa003600.01146934
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.00478069
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.00415895
133Endometrial cancer_Homo sapiens_hsa052130.00252291
134Legionellosis_Homo sapiens_hsa051340.00051074
135Apoptosis_Homo sapiens_hsa04210-0.0402518
136Tyrosine metabolism_Homo sapiens_hsa00350-0.0277279
137Ether lipid metabolism_Homo sapiens_hsa00565-0.0238708
138Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0148619

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