SAMD11P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)9.82126355
2cellular response to ethanol (GO:0071361)6.65244059
3cellular response to interleukin-15 (GO:0071350)6.42063337
4regulation of interleukin-12 biosynthetic process (GO:0045075)6.01319003
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.66645781
6regulation of regulatory T cell differentiation (GO:0045589)5.44966508
7positive regulation of fibroblast migration (GO:0010763)5.25033618
8cytidine deamination (GO:0009972)5.21959773
9cytidine metabolic process (GO:0046087)5.21959773
10cytidine catabolic process (GO:0006216)5.21959773
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.93238160
12negative regulation of B cell proliferation (GO:0030889)4.92297039
13regulation of mononuclear cell migration (GO:0071675)4.84810388
14positive regulation of synaptic transmission, GABAergic (GO:0032230)4.81479785
15negative regulation of sodium ion transport (GO:0010766)4.75949851
16regulation of T cell tolerance induction (GO:0002664)4.69279816
17dopaminergic neuron differentiation (GO:0071542)4.64404772
18regulation of macrophage chemotaxis (GO:0010758)4.52105909
19regulation of activation of Janus kinase activity (GO:0010533)4.42927731
20response to interleukin-15 (GO:0070672)4.41797942
21positive regulation of alpha-beta T cell proliferation (GO:0046641)4.35014548
22regulation of alpha-beta T cell proliferation (GO:0046640)4.32971271
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.28829383
24negative regulation of thymocyte apoptotic process (GO:0070244)4.09823261
25negative T cell selection (GO:0043383)3.95378491
26regulation of tolerance induction (GO:0002643)3.94869697
27negative regulation of B cell activation (GO:0050869)3.94819093
28T cell apoptotic process (GO:0070231)3.79378653
29positive regulation of defense response to virus by host (GO:0002230)3.75546074
30protein K11-linked deubiquitination (GO:0035871)3.73381200
31regulation of mitotic spindle organization (GO:0060236)3.72515936
32locomotory exploration behavior (GO:0035641)3.59334680
33positive T cell selection (GO:0043368)3.49988392
34regulation of T cell receptor signaling pathway (GO:0050856)3.44957174
35macrophage activation involved in immune response (GO:0002281)3.44642878
36positive regulation of uterine smooth muscle contraction (GO:0070474)3.36169185
37regulation of histone phosphorylation (GO:0033127)3.33250812
38positive regulation of tolerance induction (GO:0002645)3.32896191
39regulation of uterine smooth muscle contraction (GO:0070472)3.32019401
40inflammatory response to antigenic stimulus (GO:0002437)3.28150733
41negative regulation of osteoblast proliferation (GO:0033689)3.26756355
42DNA deamination (GO:0045006)3.26345280
43negative thymic T cell selection (GO:0045060)3.25691260
44lymphocyte apoptotic process (GO:0070227)3.24312567
45response to insecticide (GO:0017085)3.23685607
46positive regulation of viral genome replication (GO:0045070)3.20988471
47CDP-diacylglycerol biosynthetic process (GO:0016024)3.17588255
48positive regulation of calcium-mediated signaling (GO:0050850)3.13447411
49DNA strand renaturation (GO:0000733)3.13158242
50poly(A)+ mRNA export from nucleus (GO:0016973)3.10673675
51negative regulation of T cell differentiation (GO:0045581)3.06917325
52positive regulation of CREB transcription factor activity (GO:0032793)3.01117171
53thymic T cell selection (GO:0045061)3.00358227
54regulation of T-helper 2 cell differentiation (GO:0045628)2.99504361
55dopamine biosynthetic process (GO:0042416)2.97798455
56B cell receptor signaling pathway (GO:0050853)2.96770480
57regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.96716274
58DNA double-strand break processing (GO:0000729)2.96525066
59pyrimidine dimer repair (GO:0006290)2.95705116
60negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.92142484
61negative regulation of execution phase of apoptosis (GO:1900118)2.87187768
62CDP-diacylglycerol metabolic process (GO:0046341)2.87182178
63positive thymic T cell selection (GO:0045059)2.85322890
64regulation of dopamine metabolic process (GO:0042053)2.77506531
65regulation of catecholamine metabolic process (GO:0042069)2.77506531
66behavioral defense response (GO:0002209)2.75597131
67behavioral fear response (GO:0001662)2.75597131
68regulation of thymocyte apoptotic process (GO:0070243)2.75477558
69T cell selection (GO:0045058)2.75178094
70regulation of fibroblast migration (GO:0010762)2.72772740
71regulation of spindle organization (GO:0090224)2.71298793
72mitotic G2 DNA damage checkpoint (GO:0007095)2.70439492
73fear response (GO:0042596)2.69268389
74pyrimidine nucleoside catabolic process (GO:0046135)2.68361732
75monoubiquitinated protein deubiquitination (GO:0035520)2.67653908
76kinetochore assembly (GO:0051382)2.66709922
77negative regulation of DNA-dependent DNA replication (GO:2000104)2.63345742
78detection of light stimulus involved in visual perception (GO:0050908)2.61744793
79detection of light stimulus involved in sensory perception (GO:0050962)2.61744793
80T cell costimulation (GO:0031295)2.61596357
81negative regulation of sequestering of calcium ion (GO:0051283)2.61489378
82release of sequestered calcium ion into cytosol (GO:0051209)2.61489378
83regulation of pigment cell differentiation (GO:0050932)2.61420797
84ear development (GO:0043583)2.61393268
85alkaloid metabolic process (GO:0009820)2.60862749
86negative regulation of Ras GTPase activity (GO:0034261)2.60795678
87neuron maturation (GO:0042551)2.59043423
88mitochondrial DNA replication (GO:0006264)2.58688291
89lymphocyte costimulation (GO:0031294)2.57549625
90fucose catabolic process (GO:0019317)2.55844537
91L-fucose metabolic process (GO:0042354)2.55844537
92L-fucose catabolic process (GO:0042355)2.55844537
93replication fork processing (GO:0031297)2.55135058
94regulation of calcium-mediated signaling (GO:0050848)2.55062890
95positive regulation of T-helper cell differentiation (GO:0045624)2.54028719
96phosphatidylglycerol biosynthetic process (GO:0006655)2.53352931
97regulation of chronic inflammatory response (GO:0002676)2.52803725
98positive regulation of protein homooligomerization (GO:0032464)2.52413161
99behavioral response to nicotine (GO:0035095)2.49702873
100negative regulation of complement activation (GO:0045916)2.49549368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.16955978
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse6.37345747
3RBPJ_22232070_ChIP-Seq_NCS_Mouse6.20456757
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.41947138
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.95965378
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.47521451
7VDR_22108803_ChIP-Seq_LS180_Human2.66557345
8ZNF274_21170338_ChIP-Seq_K562_Hela2.33046809
9RUNX_20019798_ChIP-Seq_JUKART_Human2.24051580
10TAF15_26573619_Chip-Seq_HEK293_Human2.19284587
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10176330
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01576530
13AR_21572438_ChIP-Seq_LNCaP_Human1.97310927
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.96596183
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87890030
16GATA1_22025678_ChIP-Seq_K562_Human1.86076588
17RXR_22108803_ChIP-Seq_LS180_Human1.84805521
18MYB_26560356_Chip-Seq_TH2_Human1.84644163
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.83415098
20FOXM1_23109430_ChIP-Seq_U2OS_Human1.82874497
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67136399
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63499173
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.61778242
24MYB_26560356_Chip-Seq_TH1_Human1.60913666
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60818534
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.60549526
27TP53_16413492_ChIP-PET_HCT116_Human1.51243181
28GATA3_27048872_Chip-Seq_THYMUS_Human1.48378238
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46249287
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44412461
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43397699
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43397699
33ARNT_22903824_ChIP-Seq_MCF-7_Human1.35427995
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30992351
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30262730
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29400699
37AHR_22903824_ChIP-Seq_MCF-7_Human1.26349330
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24630725
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24028170
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22901405
41BCAT_22108803_ChIP-Seq_LS180_Human1.21884536
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21249150
43STAT3_23295773_ChIP-Seq_U87_Human1.20790065
44P300_19829295_ChIP-Seq_ESCs_Human1.20345089
45PRDM14_20953172_ChIP-Seq_ESCs_Human1.18875531
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18506105
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.18370120
48VDR_24787735_ChIP-Seq_THP-1_Human1.17008179
49GBX2_23144817_ChIP-Seq_PC3_Human1.13809828
50TCF4_22108803_ChIP-Seq_LS180_Human1.13673078
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11511181
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11503844
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10294942
54EWS_26573619_Chip-Seq_HEK293_Human1.09238742
55GATA3_26560356_Chip-Seq_TH2_Human1.08713865
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08636500
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08510410
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08449586
59SMAD3_21741376_ChIP-Seq_HESCs_Human1.06939131
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05608431
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.05375286
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05300644
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04496449
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.02915346
65SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01453351
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99548577
67PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98964036
68AR_25329375_ChIP-Seq_VCAP_Human0.98754541
69NFE2_27457419_Chip-Seq_LIVER_Mouse0.98677723
70GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96981713
71MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96381416
72SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96082128
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94909483
74SMAD3_21741376_ChIP-Seq_EPCs_Human0.94070064
75FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94043045
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92987497
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92058798
78EZH2_27294783_Chip-Seq_NPCs_Mouse0.91023894
79SMAD4_21799915_ChIP-Seq_A2780_Human0.90461091
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89954053
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89196306
82SCL_19346495_ChIP-Seq_HPC-7_Human0.88564442
83SMAD4_21741376_ChIP-Seq_HESCs_Human0.87154750
84BRD4_25478319_ChIP-Seq_HGPS_Human0.86254957
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85631798
86UTX_26944678_Chip-Seq_JUKART_Human0.85329645
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85029559
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84013056
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82737895
90SOX2_21211035_ChIP-Seq_LN229_Gbm0.82139292
91WDR5_24793694_ChIP-Seq_LNCAP_Human0.81499761
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80593910
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79415590
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79340237
95WT1_19549856_ChIP-ChIP_CCG9911_Human0.79170446
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78778375
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78751524
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78008231
99SMRT_27268052_Chip-Seq_Bcells_Human0.77608366
100GATA1_19941826_ChIP-Seq_K562_Human0.75901969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex4.62929005
2MP0000569_abnormal_digit_pigmentation4.35607292
3MP0000566_synostosis3.96805432
4MP0001873_stomach_inflammation3.46857478
5MP0005671_abnormal_response_to3.44115738
6MP0003763_abnormal_thymus_physiology3.26045947
7MP0005310_abnormal_salivary_gland3.16473502
8MP0005360_urolithiasis3.01345314
9MP0001853_heart_inflammation2.80537071
10MP0000427_abnormal_hair_cycle2.55391280
11MP0005076_abnormal_cell_differentiation2.38788653
12MP0003045_fibrosis2.29192206
13MP0000383_abnormal_hair_follicle2.26036874
14MP0008004_abnormal_stomach_pH2.25237832
15MP0001800_abnormal_humoral_immune2.15003492
16MP0004381_abnormal_hair_follicle2.10311555
17MP0002009_preneoplasia2.05645505
18MP0005451_abnormal_body_composition2.03681398
19MP0004145_abnormal_muscle_electrophysio2.02454111
20MP0002933_joint_inflammation1.86377216
21MP0010094_abnormal_chromosome_stability1.67152851
22MP0000371_diluted_coat_color1.66267186
23MP0002163_abnormal_gland_morphology1.58107359
24MP0002405_respiratory_system_inflammati1.58020282
25MP0010307_abnormal_tumor_latency1.57758542
26MP0003880_abnormal_central_pattern1.56693057
27MP0005174_abnormal_tail_pigmentation1.54437947
28MP0002723_abnormal_immune_serum1.53897073
29MP0003786_premature_aging1.52444935
30MP0005000_abnormal_immune_tolerance1.52093622
31MP0002168_other_aberrant_phenotype1.51768863
32MP0002420_abnormal_adaptive_immunity1.48514021
33MP0001819_abnormal_immune_cell1.44690272
34MP0000015_abnormal_ear_pigmentation1.41883434
35MP0002452_abnormal_antigen_presenting1.41797659
36MP0002398_abnormal_bone_marrow1.38650633
37MP0000516_abnormal_urinary_system1.35319201
38MP0005367_renal/urinary_system_phenotyp1.35319201
39MP0005253_abnormal_eye_physiology1.34991064
40MP0001348_abnormal_lacrimal_gland1.33759564
41MP0010386_abnormal_urinary_bladder1.32171211
42MP0003646_muscle_fatigue1.29340948
43MP0002938_white_spotting1.26970768
44MP0006072_abnormal_retinal_apoptosis1.26192231
45MP0000703_abnormal_thymus_morphology1.22965625
46MP0004043_abnormal_pH_regulation1.19970148
47MP0005395_other_phenotype1.19850574
48MP0002419_abnormal_innate_immunity1.18852516
49MP0010678_abnormal_skin_adnexa1.17277361
50MP0001835_abnormal_antigen_presentation1.16339643
51MP0002277_abnormal_respiratory_mucosa1.15267288
52MP0001502_abnormal_circadian_rhythm1.12632018
53MP0003329_amyloid_beta_deposits1.12224426
54MP0002075_abnormal_coat/hair_pigmentati1.11959124
55MP0002148_abnormal_hypersensitivity_rea1.10880356
56MP0000716_abnormal_immune_system1.08317481
57MP0005423_abnormal_somatic_nervous1.07789614
58MP0003724_increased_susceptibility_to1.07740544
59MP0000685_abnormal_immune_system1.07396811
60MP0001790_abnormal_immune_system1.05845133
61MP0005387_immune_system_phenotype1.05845133
62MP0008007_abnormal_cellular_replicative1.05601790
63MP0009785_altered_susceptibility_to1.05264193
64MP0002254_reproductive_system_inflammat1.03458627
65MP0005025_abnormal_response_to0.99752328
66MP0002095_abnormal_skin_pigmentation0.99488061
67MP0002876_abnormal_thyroid_physiology0.97996189
68MP0002722_abnormal_immune_system0.95930868
69MP0003436_decreased_susceptibility_to0.95718629
70MP0003950_abnormal_plasma_membrane0.94338892
71MP0000689_abnormal_spleen_morphology0.94059613
72MP0009745_abnormal_behavioral_response0.94050637
73MP0010155_abnormal_intestine_physiology0.93072296
74MP0008770_decreased_survivor_rate0.92070657
75MP0003136_yellow_coat_color0.90149676
76MP0005551_abnormal_eye_electrophysiolog0.88197442
77MP0003718_maternal_effect0.86614706
78MP0004947_skin_inflammation0.85712791
79MP0003866_abnormal_defecation0.80842070
80MP0000647_abnormal_sebaceous_gland0.79225542
81MP0001663_abnormal_digestive_system0.78516175
82MP0000749_muscle_degeneration0.77348074
83MP0008995_early_reproductive_senescence0.76217322
84MP0003690_abnormal_glial_cell0.73403218
85MP0001919_abnormal_reproductive_system0.73376211
86MP0002332_abnormal_exercise_endurance0.73322499
87MP0000372_irregular_coat_pigmentation0.72994357
88MP0002429_abnormal_blood_cell0.71341491
89MP0000538_abnormal_urinary_bladder0.71034874
90MP0002098_abnormal_vibrissa_morphology0.70802483
91MP0009763_increased_sensitivity_to0.70040232
92MP0001661_extended_life_span0.69386483
93MP0003091_abnormal_cell_migration0.67545677
94MP0000579_abnormal_nail_morphology0.65177181
95MP0002970_abnormal_white_adipose0.64506939
96MP0000604_amyloidosis0.62992257
97MP0001243_abnormal_dermal_layer0.62548389
98MP0000470_abnormal_stomach_morphology0.62198811
99MP0005075_abnormal_melanosome_morpholog0.61866813
100MP0000367_abnormal_coat/_hair0.60845342

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)6.03752397
2T lymphocytopenia (HP:0005403)5.79906643
3IgA deficiency (HP:0002720)4.95612252
4IgM deficiency (HP:0002850)4.85999540
5Sparse lateral eyebrow (HP:0005338)4.62614071
6Abnormality of the prostate (HP:0008775)4.08662710
7Ureteral stenosis (HP:0000071)3.83020778
8Squamous cell carcinoma (HP:0002860)3.71792422
9Entropion (HP:0000621)3.70510373
10Abnormality of DNA repair (HP:0003254)3.66846896
11Chronic diarrhea (HP:0002028)3.66060344
12Hyperventilation (HP:0002883)3.59309222
13Ureteral obstruction (HP:0006000)3.57773118
14Selective tooth agenesis (HP:0001592)3.51977107
15IgG deficiency (HP:0004315)3.39166661
16Abnormality of T cells (HP:0002843)3.27402204
17Dyschromatopsia (HP:0007641)3.25424005
18Autoimmune thrombocytopenia (HP:0001973)3.23682310
19Severe combined immunodeficiency (HP:0004430)3.15885155
20Abnormality of homocysteine metabolism (HP:0010919)3.06310019
21Homocystinuria (HP:0002156)3.06310019
22Dislocated radial head (HP:0003083)3.00951664
23Diplopia (HP:0000651)2.95780135
24Abnormality of binocular vision (HP:0011514)2.95780135
25Methylmalonic acidemia (HP:0002912)2.92254542
26Abnormal number of incisors (HP:0011064)2.91854376
27Sensory axonal neuropathy (HP:0003390)2.87974800
28Stomatitis (HP:0010280)2.86183653
29Hypoplasia of the thymus (HP:0000778)2.85160584
30Microvesicular hepatic steatosis (HP:0001414)2.80700242
31Neonatal respiratory distress (HP:0002643)2.78325440
32Bile duct proliferation (HP:0001408)2.77017868
33Abnormal biliary tract physiology (HP:0012439)2.77017868
34Generalized hypopigmentation of hair (HP:0011358)2.76163296
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.75632085
36Fair hair (HP:0002286)2.75305076
37Abnormality of the radial head (HP:0003995)2.74678029
38Thyroiditis (HP:0100646)2.71642639
39Autoimmune hemolytic anemia (HP:0001890)2.69879758
40Renal cortical cysts (HP:0000803)2.67338337
41Clumsiness (HP:0002312)2.62298925
42Ectropion (HP:0000656)2.55679109
43Prominent nose (HP:0000448)2.53783408
44Abnormal spermatogenesis (HP:0008669)2.51152463
45High pitched voice (HP:0001620)2.48910828
46Neonatal hypoglycemia (HP:0001998)2.45738217
47Depressed nasal tip (HP:0000437)2.44861766
48Abnormality of the 2nd finger (HP:0004100)2.40691719
49Aplasia/Hypoplasia involving the musculature (HP:0001460)2.39844824
50Recurrent fungal infections (HP:0002841)2.39369145
51Abnormality of male internal genitalia (HP:0000022)2.37340005
52Abnormality of oral frenula (HP:0000190)2.36164136
53Azoospermia (HP:0000027)2.35067826
54Abnormality of midbrain morphology (HP:0002418)2.33232839
55Molar tooth sign on MRI (HP:0002419)2.33232839
56Gait imbalance (HP:0002141)2.31271839
57Tubulointerstitial nephritis (HP:0001970)2.30252430
58Progressive muscle weakness (HP:0003323)2.29119951
59Abnormality of the fingertips (HP:0001211)2.27720794
60Combined immunodeficiency (HP:0005387)2.27255526
61Absent speech (HP:0001344)2.26650889
62Hypochromic anemia (HP:0001931)2.19766003
63Recurrent cutaneous fungal infections (HP:0011370)2.15870057
64Chronic mucocutaneous candidiasis (HP:0002728)2.15870057
65Follicular hyperkeratosis (HP:0007502)2.15775291
66Poikiloderma (HP:0001029)2.14535558
67Conjunctival telangiectasia (HP:0000524)2.14286711
68Progressive cerebellar ataxia (HP:0002073)2.12921628
69Malnutrition (HP:0004395)2.10305301
70Testicular atrophy (HP:0000029)2.06289694
71Abnormality of the nasal septum (HP:0000419)2.05499220
72Narrow palate (HP:0000189)2.02029903
73Recurrent viral infections (HP:0004429)1.99155788
74Sacral dimple (HP:0000960)1.97251466
75Abnormality of eosinophils (HP:0001879)1.97055845
76Abnormality of the humeroradial joint (HP:0100744)1.96650161
77Methylmalonic aciduria (HP:0012120)1.96559743
78Abnormality of chromosome stability (HP:0003220)1.96373146
79Abnormality of the renal cortex (HP:0011035)1.95579868
80Gaze-evoked nystagmus (HP:0000640)1.94895318
81Status epilepticus (HP:0002133)1.92848043
82Lip pit (HP:0100267)1.91684160
83Pulmonary infiltrates (HP:0002113)1.91363875
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.89236318
85Coronal craniosynostosis (HP:0004440)1.87533269
86Type I diabetes mellitus (HP:0100651)1.86244458
87Amyotrophic lateral sclerosis (HP:0007354)1.83727281
88Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83184818
89Abnormality of the vitamin B12 metabolism (HP:0004341)1.81415298
90Abnormality of the pleura (HP:0002103)1.81084172
91Neurofibrillary tangles (HP:0002185)1.77374482
92Fetal akinesia sequence (HP:0001989)1.75883868
93Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73666574
94Inappropriate behavior (HP:0000719)1.73547989
95Protruding tongue (HP:0010808)1.72819408
96Progressive external ophthalmoplegia (HP:0000590)1.72462072
97Anal stenosis (HP:0002025)1.72294085
98Type I transferrin isoform profile (HP:0003642)1.71264366
99Abnormality of the axillary hair (HP:0100134)1.70716412
100Abnormality of secondary sexual hair (HP:0009888)1.70716412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK9.53265005
2MKNK22.71851919
3ACVR1B2.68743557
4AKT32.63941538
5MAPK132.46684529
6WNK32.44450852
7TRIB32.40306158
8MAPK112.30421931
9ITK2.19744162
10MARK12.15954893
11PHKG11.95197778
12PHKG21.95197778
13BUB11.92863317
14FRK1.77368685
15NME11.72797785
16TLK11.71623500
17TEC1.52906544
18ADRBK21.51663723
19CDK121.51104321
20PIM21.42310440
21TTK1.39340755
22PKN11.37321010
23MAPKAPK31.30974219
24BTK1.29579330
25PLK41.29087586
26BCR1.28358196
27MKNK11.23309553
28MAPK121.18048786
29GRK71.17876188
30DAPK21.16691457
31TRPM71.13446840
32NTRK31.10819869
33MARK31.09342483
34PIM11.05903559
35PIK3CA1.03672727
36EEF2K1.02973756
37RIPK11.00992560
38RPS6KA41.00870087
39MAP4K10.98435116
40SYK0.96761089
41CSK0.93417289
42MELK0.88118962
43DYRK1A0.85843478
44MARK20.81179481
45OXSR10.80632776
46PDK10.78403528
47MAP3K100.76415719
48VRK10.75913007
49STK100.75168086
50ZAK0.74017544
51PDPK10.72347064
52BLK0.72133175
53SIK20.71637934
54CASK0.71504412
55TAOK30.67055786
56EIF2AK20.66062348
57PDK20.64473616
58MAP3K70.64314476
59GRK60.58835584
60BMPR1B0.58660981
61LCK0.55920762
62GSK3A0.55424012
63PRKCQ0.55215167
64DYRK20.53818214
65MTOR0.53542743
66STK390.48166938
67WNK40.47651858
68ICK0.44776949
69MAP2K30.42516803
70CHEK20.41999650
71MAPK150.40737562
72PTK2B0.40175736
73JAK20.39232999
74PRKAA10.38948761
75PRKCE0.38709276
76MAPKAPK20.38585237
77RPS6KA10.38379074
78CDC42BPA0.37893817
79LYN0.37093585
80NTRK20.33653541
81STK38L0.33002870
82CHUK0.32930647
83PIK3CG0.32324275
84ABL20.32066160
85IKBKB0.31477072
86MAP3K140.30159315
87BMPR20.28940686
88MAP4K20.28463428
89MAPK90.28366806
90ATR0.28008898
91FES0.26887303
92ZAP700.26641482
93FYN0.25368854
94JAK30.23594184
95MAPK10.23469334
96RPS6KA50.23118475
97ABL10.23116915
98HCK0.20343433
99PAK20.20269085
100CAMKK20.20028483

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053203.52081087
2Primary immunodeficiency_Homo sapiens_hsa053403.43691132
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.84455260
4Rheumatoid arthritis_Homo sapiens_hsa053232.47526875
5T cell receptor signaling pathway_Homo sapiens_hsa046602.37080676
6Homologous recombination_Homo sapiens_hsa034402.31352212
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.30585757
8Graft-versus-host disease_Homo sapiens_hsa053322.23951640
9Allograft rejection_Homo sapiens_hsa053301.97487321
10Glycerolipid metabolism_Homo sapiens_hsa005611.91786411
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82802451
12Hematopoietic cell lineage_Homo sapiens_hsa046401.80841807
13Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.71763716
14One carbon pool by folate_Homo sapiens_hsa006701.68338437
15Measles_Homo sapiens_hsa051621.65031318
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63707269
17Systemic lupus erythematosus_Homo sapiens_hsa053221.62487892
18Vitamin digestion and absorption_Homo sapiens_hsa049771.57302609
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56337190
20Lysine degradation_Homo sapiens_hsa003101.55414010
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50758579
22p53 signaling pathway_Homo sapiens_hsa041151.49474626
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48764846
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.48106431
25Antigen processing and presentation_Homo sapiens_hsa046121.45833860
26Fanconi anemia pathway_Homo sapiens_hsa034601.44637721
27Staphylococcus aureus infection_Homo sapiens_hsa051501.43655532
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.38994155
29Type I diabetes mellitus_Homo sapiens_hsa049401.37461183
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37390224
31Histidine metabolism_Homo sapiens_hsa003401.34252893
32Circadian rhythm_Homo sapiens_hsa047101.31292679
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18454865
34Taste transduction_Homo sapiens_hsa047421.14683331
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13901707
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08008109
37ABC transporters_Homo sapiens_hsa020101.07329584
38HTLV-I infection_Homo sapiens_hsa051661.00252789
39Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99890271
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94619808
41TNF signaling pathway_Homo sapiens_hsa046680.93813052
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.91977795
43beta-Alanine metabolism_Homo sapiens_hsa004100.91867949
44Salmonella infection_Homo sapiens_hsa051320.88825197
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87845380
46Olfactory transduction_Homo sapiens_hsa047400.86884641
47FoxO signaling pathway_Homo sapiens_hsa040680.86111512
48Insulin resistance_Homo sapiens_hsa049310.82142387
49RNA polymerase_Homo sapiens_hsa030200.80320855
50TGF-beta signaling pathway_Homo sapiens_hsa043500.79124410
51Type II diabetes mellitus_Homo sapiens_hsa049300.79121439
52MicroRNAs in cancer_Homo sapiens_hsa052060.78547150
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77214936
54Morphine addiction_Homo sapiens_hsa050320.76431758
55Chemokine signaling pathway_Homo sapiens_hsa040620.75540402
56Notch signaling pathway_Homo sapiens_hsa043300.72888714
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71840710
58Osteoclast differentiation_Homo sapiens_hsa043800.69562788
59Nucleotide excision repair_Homo sapiens_hsa034200.68512233
60Phototransduction_Homo sapiens_hsa047440.67718820
61Tuberculosis_Homo sapiens_hsa051520.66805860
62Asthma_Homo sapiens_hsa053100.64898890
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64546116
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63593124
65MAPK signaling pathway_Homo sapiens_hsa040100.62074412
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59940709
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.55732548
68Alcoholism_Homo sapiens_hsa050340.55437362
69Hepatitis B_Homo sapiens_hsa051610.55115325
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54665878
71Selenocompound metabolism_Homo sapiens_hsa004500.53250266
72RNA degradation_Homo sapiens_hsa030180.52160064
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51651463
74Nicotine addiction_Homo sapiens_hsa050330.51190056
75African trypanosomiasis_Homo sapiens_hsa051430.50135185
76Retinol metabolism_Homo sapiens_hsa008300.48673940
77Toxoplasmosis_Homo sapiens_hsa051450.47393581
78Arachidonic acid metabolism_Homo sapiens_hsa005900.47056406
79Complement and coagulation cascades_Homo sapiens_hsa046100.44518540
80Viral carcinogenesis_Homo sapiens_hsa052030.43408912
81Leishmaniasis_Homo sapiens_hsa051400.43005828
82Influenza A_Homo sapiens_hsa051640.41385186
83Cell cycle_Homo sapiens_hsa041100.39787379
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38309936
85cAMP signaling pathway_Homo sapiens_hsa040240.37814917
86Apoptosis_Homo sapiens_hsa042100.37383275
87Ether lipid metabolism_Homo sapiens_hsa005650.36464375
88Calcium signaling pathway_Homo sapiens_hsa040200.36419191
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35833361
90Salivary secretion_Homo sapiens_hsa049700.35811581
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.35192785
92Ovarian steroidogenesis_Homo sapiens_hsa049130.33369233
93Platelet activation_Homo sapiens_hsa046110.31923337
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31415133
95Endocytosis_Homo sapiens_hsa041440.30560541
96Linoleic acid metabolism_Homo sapiens_hsa005910.30166678
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30115872
98Tryptophan metabolism_Homo sapiens_hsa003800.29872150
99Small cell lung cancer_Homo sapiens_hsa052220.29818268
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.29594215

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