SAMD12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.55447849
2synaptic vesicle exocytosis (GO:0016079)5.21946204
3vocalization behavior (GO:0071625)5.14015495
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.83916140
5response to histamine (GO:0034776)4.82852710
6protein localization to synapse (GO:0035418)4.80270317
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.75696075
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.74520204
9presynaptic membrane assembly (GO:0097105)4.73338946
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.58294315
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.51468664
12neurotransmitter-gated ion channel clustering (GO:0072578)4.50988211
13regulation of glutamate receptor signaling pathway (GO:1900449)4.49370111
14postsynaptic membrane organization (GO:0001941)4.49217243
15neuron-neuron synaptic transmission (GO:0007270)4.39413611
16glutamate secretion (GO:0014047)4.35972821
17glutamate receptor signaling pathway (GO:0007215)4.27690136
18presynaptic membrane organization (GO:0097090)4.23880863
19synaptic transmission, glutamatergic (GO:0035249)4.21842804
20regulation of synaptic vesicle exocytosis (GO:2000300)4.14760295
21locomotory exploration behavior (GO:0035641)4.10521577
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.06567156
23neuronal action potential propagation (GO:0019227)3.98073596
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.97832214
25negative regulation of synaptic transmission, GABAergic (GO:0032229)3.92890255
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86575403
27long-term synaptic potentiation (GO:0060291)3.83180723
28neurotransmitter secretion (GO:0007269)3.81517742
29negative regulation of dendrite morphogenesis (GO:0050774)3.78615521
30exploration behavior (GO:0035640)3.74841225
31neuron recognition (GO:0008038)3.72731783
32positive regulation of synaptic transmission, GABAergic (GO:0032230)3.69550476
33regulation of synaptic vesicle transport (GO:1902803)3.64518037
34negative regulation of dendrite development (GO:2000171)3.62682392
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.62308333
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.57386116
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.55861778
38adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.49388222
39proline transport (GO:0015824)3.49324945
40regulation of postsynaptic membrane potential (GO:0060078)3.48343495
41negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.46778347
42regulation of neuronal synaptic plasticity (GO:0048168)3.46475235
43synaptic vesicle maturation (GO:0016188)3.46313867
44regulation of synaptic transmission, glutamatergic (GO:0051966)3.45314181
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.44472040
46negative regulation of hormone biosynthetic process (GO:0032353)3.43353928
47serotonin metabolic process (GO:0042428)3.42939435
48synaptic transmission, dopaminergic (GO:0001963)3.40735652
49positive regulation of synapse assembly (GO:0051965)3.39746996
50positive regulation of membrane potential (GO:0045838)3.39105811
51regulation of type B pancreatic cell apoptotic process (GO:2000674)3.37317551
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.34067810
53righting reflex (GO:0060013)3.32097465
54dopamine transport (GO:0015872)3.30206482
55synaptic vesicle endocytosis (GO:0048488)3.30129195
56regulation of synapse structural plasticity (GO:0051823)3.29281000
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27323911
58insulin secretion (GO:0030073)3.25967960
59negative regulation of cytosolic calcium ion concentration (GO:0051481)3.25469698
60gamma-aminobutyric acid transport (GO:0015812)3.23818013
61transmission of nerve impulse (GO:0019226)3.23216462
62regulation of synaptic plasticity (GO:0048167)3.21792557
63ATP hydrolysis coupled proton transport (GO:0015991)3.19901370
64energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.19901370
65cellular response to ammonium ion (GO:0071242)3.15021033
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14015420
67axonal fasciculation (GO:0007413)3.13798917
68primary amino compound metabolic process (GO:1901160)3.13110901
69regulation of glutamate secretion (GO:0014048)3.11949176
70neurotransmitter transport (GO:0006836)3.11859552
71regulation of female receptivity (GO:0045924)3.11199611
72water-soluble vitamin biosynthetic process (GO:0042364)3.10093993
73cell migration in hindbrain (GO:0021535)3.10014391
74positive regulation of protein autophosphorylation (GO:0031954)3.09864889
75startle response (GO:0001964)3.09721155
76synapse assembly (GO:0007416)3.09529642
77regulation of axon regeneration (GO:0048679)3.08934034
78regulation of neuron projection regeneration (GO:0070570)3.08934034
79cerebellar granule cell differentiation (GO:0021707)3.07471055
80long-term memory (GO:0007616)3.06408678
81membrane depolarization (GO:0051899)3.05884689
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05604395
83female mating behavior (GO:0060180)3.05368030
84layer formation in cerebral cortex (GO:0021819)3.03902401
85membrane hyperpolarization (GO:0060081)3.03753106
86regulation of vesicle fusion (GO:0031338)3.03607552
87long term synaptic depression (GO:0060292)3.02509277
88cellular potassium ion homeostasis (GO:0030007)3.00926647
89innervation (GO:0060384)3.00614436
90learning (GO:0007612)3.00225918
91regulation of synaptic transmission, GABAergic (GO:0032228)3.00129068
92regulation of neurotransmitter secretion (GO:0046928)2.99656031
93negative regulation of hormone metabolic process (GO:0032351)2.98773898
94regulation of dendritic spine morphogenesis (GO:0061001)2.98588436
95transferrin transport (GO:0033572)2.98312646
96detection of calcium ion (GO:0005513)2.97576143
97L-fucose catabolic process (GO:0042355)2.97106768
98fucose catabolic process (GO:0019317)2.97106768
99L-fucose metabolic process (GO:0042354)2.97106768
100dendritic spine morphogenesis (GO:0060997)2.93797377
101membrane depolarization during action potential (GO:0086010)2.92818313
102synaptic transmission (GO:0007268)2.92672722
103dopamine receptor signaling pathway (GO:0007212)2.91739556
104regulation of neurotransmitter levels (GO:0001505)2.91540207
105positive regulation of synapse maturation (GO:0090129)2.90705512
106positive regulation of synaptic transmission (GO:0050806)2.90233191
107behavioral response to ethanol (GO:0048149)2.89441462
108positive regulation of neurotransmitter secretion (GO:0001956)2.88012008
109phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.87056741
110calcium-mediated signaling using intracellular calcium source (GO:0035584)2.86552530
111behavioral response to cocaine (GO:0048148)2.84822511
112response to cocaine (GO:0042220)2.84041231
113regulation of synapse assembly (GO:0051963)2.83919602
114detection of light stimulus involved in visual perception (GO:0050908)2.83775087
115detection of light stimulus involved in sensory perception (GO:0050962)2.83775087
116inositol phosphate catabolic process (GO:0071545)2.82622856
117cerebellar Purkinje cell differentiation (GO:0021702)2.82236103
118cochlea development (GO:0090102)2.81509431
119reflex (GO:0060004)2.80737747
120regulation of calcium ion-dependent exocytosis (GO:0017158)2.79793667
121regulation of heart rate by cardiac conduction (GO:0086091)2.77895223
122regulation of hexokinase activity (GO:1903299)2.75282922
123regulation of glucokinase activity (GO:0033131)2.75282922
124cellular ketone body metabolic process (GO:0046950)2.75203647
125neuronal action potential (GO:0019228)2.72518195
126cardiac conduction (GO:0061337)2.71332340
127membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.67926730
128retinal cone cell development (GO:0046549)2.67826878
129action potential (GO:0001508)2.67734047
1303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.66875900
131purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.66875900
132sulfation (GO:0051923)2.66644619
133establishment of protein localization to Golgi (GO:0072600)2.65726296
134inositol phosphate dephosphorylation (GO:0046855)2.63942153
135phosphorylated carbohydrate dephosphorylation (GO:0046838)2.63942153
136regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.61830430
137response to amphetamine (GO:0001975)2.61125006
138regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.59619915
139regulation of neurotransmitter uptake (GO:0051580)2.59403827
140calcium ion-dependent exocytosis (GO:0017156)2.56257542
141protein polyglutamylation (GO:0018095)2.54571405
142regulation of sodium ion transmembrane transporter activity (GO:2000649)2.52448395
143calcium ion import (GO:0070509)2.51128197
144inositol phosphate-mediated signaling (GO:0048016)2.50745618
145multicellular organismal signaling (GO:0035637)2.49059556
146sleep (GO:0030431)2.48752919
147protein targeting to Golgi (GO:0000042)2.48207295
148keratinocyte development (GO:0003334)2.47562916
149protein K11-linked deubiquitination (GO:0035871)2.47562709
150behavioral response to nicotine (GO:0035095)2.46144323
151chemosensory behavior (GO:0007635)2.44916296
152regulation of neurotransmitter transport (GO:0051588)2.44872800
153potassium ion transport (GO:0006813)2.44349225
154detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44335672
155glycosphingolipid biosynthetic process (GO:0006688)2.42830982
156ketone body metabolic process (GO:1902224)2.40982528
157cellular potassium ion transport (GO:0071804)2.39851424
158potassium ion transmembrane transport (GO:0071805)2.39851424
159dopamine biosynthetic process (GO:0042416)2.39734951
160retrograde transport, vesicle recycling within Golgi (GO:0000301)2.39411875
161axoneme assembly (GO:0035082)2.39316919
162relaxation of cardiac muscle (GO:0055119)2.39074962
163magnesium ion transport (GO:0015693)2.38955209
164positive regulation of meiosis (GO:0045836)2.37866567
165negative regulation of systemic arterial blood pressure (GO:0003085)2.37369437
166regulation of action potential (GO:0098900)2.37069823
167membrane repolarization during action potential (GO:0086011)2.37030164
168G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.37012945
169regulation of acrosome reaction (GO:0060046)2.34162086
170positive regulation of potassium ion transmembrane transport (GO:1901381)2.33953434
171prostate gland growth (GO:0060736)2.33866133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.54511206
2GBX2_23144817_ChIP-Seq_PC3_Human4.57884063
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.39702072
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17777945
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02442904
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02215152
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69389106
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60244428
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57327416
10TAF15_26573619_Chip-Seq_HEK293_Human2.56762307
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55533342
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.48893767
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46263306
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46263306
15REST_21632747_ChIP-Seq_MESCs_Mouse2.34630831
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33488996
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.31039400
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30795090
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26808171
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12585776
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12027340
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06536572
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04561284
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.99621180
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96677388
26SMAD4_21799915_ChIP-Seq_A2780_Human1.94227823
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.93969138
28* P300_19829295_ChIP-Seq_ESCs_Human1.92649982
29* RARB_27405468_Chip-Seq_BRAIN_Mouse1.92031694
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.88929368
31ZNF274_21170338_ChIP-Seq_K562_Hela1.87407300
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86825066
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83830977
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78244310
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77704606
36DROSHA_22980978_ChIP-Seq_HELA_Human1.75775693
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74587140
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72646235
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66241254
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65339817
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65324446
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62650422
43AR_21572438_ChIP-Seq_LNCaP_Human1.60242862
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.58328909
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57253903
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55574005
47AR_25329375_ChIP-Seq_VCAP_Human1.54880273
48FUS_26573619_Chip-Seq_HEK293_Human1.54839272
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.53923577
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51501387
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51267962
52* SMAD3_21741376_ChIP-Seq_EPCs_Human1.50689165
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46715027
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46400057
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42205539
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41209446
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40235082
58* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38095643
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37807137
60CBP_20019798_ChIP-Seq_JUKART_Human1.37807137
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36476310
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34439765
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.31276299
64* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29323633
65P53_22387025_ChIP-Seq_ESCs_Mouse1.28228475
66STAT3_23295773_ChIP-Seq_U87_Human1.25354893
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24879335
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.24827360
69TP53_18474530_ChIP-ChIP_U2OS_Human1.23689096
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23205942
71RNF2_27304074_Chip-Seq_NSC_Mouse1.21728165
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21315340
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.21095673
74BCAT_22108803_ChIP-Seq_LS180_Human1.21032639
75* PRDM14_20953172_ChIP-Seq_ESCs_Human1.20096730
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.19869576
77* AHR_22903824_ChIP-Seq_MCF-7_Human1.19753800
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19347982
79TCF4_23295773_ChIP-Seq_U87_Human1.18882834
80CDX2_22108803_ChIP-Seq_LS180_Human1.18433781
81IGF1R_20145208_ChIP-Seq_DFB_Human1.17485402
82* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17425390
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17112519
84* SMAD4_21741376_ChIP-Seq_EPCs_Human1.16967236
85* RUNX2_22187159_ChIP-Seq_PCA_Human1.16752454
86* ARNT_22903824_ChIP-Seq_MCF-7_Human1.16450459
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16107567
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.15532319
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.15166818
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.14681114
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.12941621
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11369702
93TP53_16413492_ChIP-PET_HCT116_Human1.11167869
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.11082345
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09781469
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.09686305
97* JUN_21703547_ChIP-Seq_K562_Human1.09483137
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.09412250
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09362982
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09048032
101SMAD3_21741376_ChIP-Seq_HESCs_Human1.08035811
102P300_18555785_Chip-Seq_ESCs_Mouse1.07906158
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06847972
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.05727604
105TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05341284
106ER_23166858_ChIP-Seq_MCF-7_Human1.05187333
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04339151
108KDM2B_26808549_Chip-Seq_REH_Human1.03183175
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02893632
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.02478161
111EWS_26573619_Chip-Seq_HEK293_Human1.02300027
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01683941
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01484031
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01484031
115* AR_19668381_ChIP-Seq_PC3_Human0.98442705
116VDR_22108803_ChIP-Seq_LS180_Human0.97640084
117TCF4_22108803_ChIP-Seq_LS180_Human0.97639724
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96598783
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96585442
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96249372
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96102249
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.95804476
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.94603765
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94268841
125RING1B_27294783_Chip-Seq_NPCs_Mouse0.93971276
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93303172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.98601853
2MP0003880_abnormal_central_pattern4.77800677
3MP0001968_abnormal_touch/_nociception4.18886710
4MP0002736_abnormal_nociception_after4.01352503
5MP0003635_abnormal_synaptic_transmissio3.76022861
6MP0004270_analgesia3.71037807
7MP0009745_abnormal_behavioral_response3.26763885
8MP0002735_abnormal_chemical_nociception3.24667471
9MP0002063_abnormal_learning/memory/cond3.02432528
10MP0002064_seizures2.91284049
11MP0002822_catalepsy2.84381535
12MP0002734_abnormal_mechanical_nocicepti2.81894385
13MP0002572_abnormal_emotion/affect_behav2.73966630
14MP0009046_muscle_twitch2.69008738
15MP0002272_abnormal_nervous_system2.63366999
16MP0003195_calcinosis2.54465176
17MP0006276_abnormal_autonomic_nervous2.51460250
18MP0002733_abnormal_thermal_nociception2.45333790
19MP0008877_abnormal_DNA_methylation2.36030063
20MP0001501_abnormal_sleep_pattern2.35404352
21MP0010234_abnormal_vibrissa_follicle2.35317138
22MP0001440_abnormal_grooming_behavior2.22430962
23MP0001486_abnormal_startle_reflex2.19511962
24MP0001970_abnormal_pain_threshold2.14663618
25MP0002067_abnormal_sensory_capabilities2.09391856
26MP0002184_abnormal_innervation2.04099198
27MP0003283_abnormal_digestive_organ1.98208961
28MP0005423_abnormal_somatic_nervous1.96247274
29MP0001188_hyperpigmentation1.83955805
30MP0003787_abnormal_imprinting1.83627575
31MP0004858_abnormal_nervous_system1.79390042
32MP0005646_abnormal_pituitary_gland1.76068119
33MP0002557_abnormal_social/conspecific_i1.74409615
34MP0003329_amyloid_beta_deposits1.68739091
35MP0010678_abnormal_skin_adnexa1.68370499
36MP0001984_abnormal_olfaction1.68050239
37MP0006072_abnormal_retinal_apoptosis1.67139395
38MP0001529_abnormal_vocalization1.64601629
39MP0000778_abnormal_nervous_system1.64190854
40MP0004924_abnormal_behavior1.62463434
41MP0005386_behavior/neurological_phenoty1.62463434
42MP0002909_abnormal_adrenal_gland1.61226726
43MP0004885_abnormal_endolymph1.56811313
44MP0002163_abnormal_gland_morphology1.54731543
45MP0004811_abnormal_neuron_physiology1.54493152
46MP0001905_abnormal_dopamine_level1.53811337
47MP0004043_abnormal_pH_regulation1.51999332
48MP0002837_dystrophic_cardiac_calcinosis1.47731310
49MP0009379_abnormal_foot_pigmentation1.46511235
50MP0002160_abnormal_reproductive_system1.43654784
51MP0003879_abnormal_hair_cell1.40573368
52MP0000427_abnormal_hair_cycle1.40552031
53MP0002102_abnormal_ear_morphology1.39790754
54MP0010386_abnormal_urinary_bladder1.38691473
55MP0002928_abnormal_bile_duct1.37753928
56MP0000383_abnormal_hair_follicle1.37067157
57MP0000955_abnormal_spinal_cord1.35658428
58MP0008569_lethality_at_weaning1.35655127
59MP0004142_abnormal_muscle_tone1.29376649
60MP0002882_abnormal_neuron_morphology1.28430206
61MP0001986_abnormal_taste_sensitivity1.28231376
62MP0009780_abnormal_chondrocyte_physiolo1.28230949
63MP0002066_abnormal_motor_capabilities/c1.26016246
64MP0005253_abnormal_eye_physiology1.24910835
65MP0001944_abnormal_pancreas_morphology1.21191340
66MP0001502_abnormal_circadian_rhythm1.15866493
67MP0002876_abnormal_thyroid_physiology1.14339710
68MP0005645_abnormal_hypothalamus_physiol1.12214627
69MP0005220_abnormal_exocrine_pancreas1.11666021
70MP0002138_abnormal_hepatobiliary_system1.11466090
71MP0001765_abnormal_ion_homeostasis1.10827048
72MP0004147_increased_porphyrin_level1.10724898
73MP0005171_absent_coat_pigmentation1.06499729
74MP0002693_abnormal_pancreas_physiology1.05799125
75MP0000569_abnormal_digit_pigmentation1.04783283
76MP0008874_decreased_physiological_sensi1.02070162
77MP0004742_abnormal_vestibular_system1.00041125
78MP0003122_maternal_imprinting0.99348694
79MP0004145_abnormal_muscle_electrophysio0.98091843
80MP0002638_abnormal_pupillary_reflex0.95893425
81MP0008875_abnormal_xenobiotic_pharmacok0.95655077
82MP0000613_abnormal_salivary_gland0.95230804
83MP0003136_yellow_coat_color0.92817844
84MP0003045_fibrosis0.92532980
85MP0003633_abnormal_nervous_system0.91402029
86MP0003631_nervous_system_phenotype0.91027262
87MP0000751_myopathy0.90925194
88MP0002152_abnormal_brain_morphology0.89663770
89MP0005367_renal/urinary_system_phenotyp0.89452975
90MP0000516_abnormal_urinary_system0.89452975
91MP0005389_reproductive_system_phenotype0.88972932
92MP0003119_abnormal_digestive_system0.88777889
93MP0004134_abnormal_chest_morphology0.86052677
94MP0002069_abnormal_eating/drinking_beha0.85533182
95MP0001963_abnormal_hearing_physiology0.84795944
96MP0004085_abnormal_heartbeat0.83755952
97MP0001756_abnormal_urination0.83719688
98MP0000013_abnormal_adipose_tissue0.83068895
99MP0001664_abnormal_digestion0.83067716
100MP0003632_abnormal_nervous_system0.82450530
101MP0005084_abnormal_gallbladder_morpholo0.81941597
102MP0002234_abnormal_pharynx_morphology0.81285044
103MP0002229_neurodegeneration0.80950360
104MP0008872_abnormal_physiological_respon0.79668993
105MP0003252_abnormal_bile_duct0.79358384
106MP0000538_abnormal_urinary_bladder0.76817713
107MP0002752_abnormal_somatic_nervous0.76492323
108MP0005409_darkened_coat_color0.75627968
109MP0005551_abnormal_eye_electrophysiolog0.75153990
110MP0006292_abnormal_olfactory_placode0.73720781
111MP0000604_amyloidosis0.73289354
112MP0005623_abnormal_meninges_morphology0.72920164
113MP0000681_abnormal_thyroid_gland0.72215925
114MP0004133_heterotaxia0.71375265
115MP0004484_altered_response_of0.71170295
116MP0005332_abnormal_amino_acid0.69952164
117MP0000639_abnormal_adrenal_gland0.68540993
118MP0004215_abnormal_myocardial_fiber0.68245706
119MP0001177_atelectasis0.67456983
120MP0002751_abnormal_autonomic_nervous0.67306719
121MP0005410_abnormal_fertilization0.67280341
122MP0005379_endocrine/exocrine_gland_phen0.66951906
123MP0003634_abnormal_glial_cell0.66014741
124MP0000631_abnormal_neuroendocrine_gland0.61861917
125MP0003183_abnormal_peptide_metabolism0.60375172
126MP0000015_abnormal_ear_pigmentation0.59132008
127MP0005535_abnormal_body_temperature0.57953678
128MP0002653_abnormal_ependyma_morphology0.57189490
129MP0004036_abnormal_muscle_relaxation0.56705318
130MP0000026_abnormal_inner_ear0.56236607
131MP0004883_abnormal_blood_vessel0.55209269
132MP0001943_abnormal_respiration0.53853230
133MP0001485_abnormal_pinna_reflex0.52585941
134MP0005174_abnormal_tail_pigmentation0.51782367
135MP0002090_abnormal_vision0.51081991
136MP0010770_preweaning_lethality0.47178705
137MP0002082_postnatal_lethality0.47178705
138MP0003121_genomic_imprinting0.45622961

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.08140937
2Atonic seizures (HP:0010819)5.64244441
3Focal seizures (HP:0007359)5.53720377
4Myokymia (HP:0002411)5.13813064
5Visual hallucinations (HP:0002367)5.09322416
6Epileptic encephalopathy (HP:0200134)5.05255559
7Febrile seizures (HP:0002373)4.86472446
8Absence seizures (HP:0002121)4.39668855
9Hyperventilation (HP:0002883)4.37673736
10Dialeptic seizures (HP:0011146)4.06523059
11Progressive cerebellar ataxia (HP:0002073)3.79570164
12Generalized tonic-clonic seizures (HP:0002069)3.70099515
13Hypothermia (HP:0002045)3.27458835
14Broad-based gait (HP:0002136)3.24567708
15Action tremor (HP:0002345)3.20300597
16Pancreatic cysts (HP:0001737)3.09074751
17Limb dystonia (HP:0002451)3.03233316
18Amblyopia (HP:0000646)3.02783104
19Abnormality of the renal cortex (HP:0011035)2.83755620
20Congenital stationary night blindness (HP:0007642)2.82495724
21Poor eye contact (HP:0000817)2.78347862
22Pancreatic fibrosis (HP:0100732)2.76270271
23Cerebral inclusion bodies (HP:0100314)2.76116745
24Impaired vibration sensation in the lower limbs (HP:0002166)2.75419588
25Gait imbalance (HP:0002141)2.73628517
26Gaze-evoked nystagmus (HP:0000640)2.66595621
27Pheochromocytoma (HP:0002666)2.59679867
28Abnormal eating behavior (HP:0100738)2.59180087
29Abnormal hair whorl (HP:0010721)2.58950616
30Neurofibrillary tangles (HP:0002185)2.58622039
31Termporal pattern (HP:0011008)2.58396541
32Insidious onset (HP:0003587)2.58396541
33Excessive salivation (HP:0003781)2.57825922
34Drooling (HP:0002307)2.57825922
35Supranuclear gaze palsy (HP:0000605)2.56757399
36Anxiety (HP:0000739)2.51097603
37Progressive inability to walk (HP:0002505)2.50037796
38True hermaphroditism (HP:0010459)2.48422739
39Abolished electroretinogram (ERG) (HP:0000550)2.47048534
40Polyphagia (HP:0002591)2.46482339
41Scanning speech (HP:0002168)2.46211931
42Congenital sensorineural hearing impairment (HP:0008527)2.43943901
43Nephronophthisis (HP:0000090)2.42859659
44Neuroendocrine neoplasm (HP:0100634)2.41461676
45Aplasia/Hypoplasia of the fovea (HP:0008060)2.40671498
46Hypoplasia of the fovea (HP:0007750)2.40671498
47Depression (HP:0000716)2.40051269
48Epileptiform EEG discharges (HP:0011182)2.39787800
49Increased circulating renin level (HP:0000848)2.39602463
50Ankle clonus (HP:0011448)2.38947570
51Hamartoma of the eye (HP:0010568)2.37872151
52Abnormal mitochondria in muscle tissue (HP:0008316)2.37236219
53Truncal ataxia (HP:0002078)2.36883588
54Mutism (HP:0002300)2.35933486
55Fetal akinesia sequence (HP:0001989)2.35718887
56Acute necrotizing encephalopathy (HP:0006965)2.35694825
57Dysdiadochokinesis (HP:0002075)2.35661087
58Progressive macrocephaly (HP:0004481)2.35094001
59Ketoacidosis (HP:0001993)2.34689454
60Inability to walk (HP:0002540)2.34488751
61Abnormality of the corticospinal tract (HP:0002492)2.34285204
62Dysmetria (HP:0001310)2.33393894
63Renal cortical cysts (HP:0000803)2.31632054
64Methylmalonic acidemia (HP:0002912)2.31289171
65Mitochondrial inheritance (HP:0001427)2.31273777
66Molar tooth sign on MRI (HP:0002419)2.30518955
67Abnormality of midbrain morphology (HP:0002418)2.30518955
68Abnormality of macular pigmentation (HP:0008002)2.29266728
69Congenital primary aphakia (HP:0007707)2.28859983
70Abnormal social behavior (HP:0012433)2.28811211
71Impaired social interactions (HP:0000735)2.28811211
72Diplopia (HP:0000651)2.26689320
73Abnormality of binocular vision (HP:0011514)2.26689320
74Abnormal rod and cone electroretinograms (HP:0008323)2.26653617
75Medial flaring of the eyebrow (HP:0010747)2.26630699
76Generalized myoclonic seizures (HP:0002123)2.25290796
77Polydipsia (HP:0001959)2.24235834
78Abnormal drinking behavior (HP:0030082)2.24235834
79Abnormality of the renal medulla (HP:0100957)2.21918534
80Urinary bladder sphincter dysfunction (HP:0002839)2.21823248
81Blue irides (HP:0000635)2.18411990
82Attenuation of retinal blood vessels (HP:0007843)2.17465417
83Abnormality of renin-angiotensin system (HP:0000847)2.17189479
84EEG with generalized epileptiform discharges (HP:0011198)2.16025412
85Ulnar claw (HP:0001178)2.15459789
86Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.14156292
87Hyperglycemia (HP:0003074)2.13513173
88Hemiparesis (HP:0001269)2.12281166
89Furrowed tongue (HP:0000221)2.12196259
90Autoamputation (HP:0001218)2.11734761
91Genetic anticipation (HP:0003743)2.11723892
92Decreased circulating renin level (HP:0003351)2.11714619
93Decreased central vision (HP:0007663)2.10352580
94Neoplasm of the adrenal cortex (HP:0100641)2.09432488
95Stereotypic behavior (HP:0000733)2.08859636
96Abnormality of vitamin B metabolism (HP:0004340)2.08665759
97Protruding tongue (HP:0010808)2.08515260
98Nephrogenic diabetes insipidus (HP:0009806)2.06693217
99Exotropia (HP:0000577)2.04947777
100Impaired pain sensation (HP:0007328)2.04538342
101Abnormality of pain sensation (HP:0010832)2.04538342
102Hypoglycemic seizures (HP:0002173)2.04255701
103Genital tract atresia (HP:0001827)2.04189317
104Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.04035742
105Short 1st metacarpal (HP:0010034)2.04035742
106Bradykinesia (HP:0002067)2.03453825
107Hyperthyroidism (HP:0000836)2.03448365
108Hypomagnesemia (HP:0002917)2.01335306
109Abnormal pancreas size (HP:0012094)2.01023130
110Akinesia (HP:0002304)2.00813106
111Abnormality of the fovea (HP:0000493)2.00777679
112Hyperinsulinemic hypoglycemia (HP:0000825)2.00458917
113Large for gestational age (HP:0001520)2.00212932
114Abnormality of the nasal septum (HP:0000419)1.99630753
115Congenital, generalized hypertrichosis (HP:0004540)1.99566801
116Hypsarrhythmia (HP:0002521)1.98395811
117Heterochromia iridis (HP:0001100)1.96693998
118Insulin-resistant diabetes mellitus (HP:0000831)1.95251050
119Urinary urgency (HP:0000012)1.95216966
120Incomplete penetrance (HP:0003829)1.95049333
121Cystic liver disease (HP:0006706)1.95020865
122Spastic gait (HP:0002064)1.93966391
123Syncope (HP:0001279)1.93903127
124Impaired smooth pursuit (HP:0007772)1.93686267
125Shoulder girdle muscle weakness (HP:0003547)1.93648982
126Agitation (HP:0000713)1.93628464
127Goiter (HP:0000853)1.93086181
128Dysautonomia (HP:0002459)1.92392979
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.91961436
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91961436
131Aqueductal stenosis (HP:0002410)1.91466461
132Intention tremor (HP:0002080)1.91103861
133Tubular atrophy (HP:0000092)1.91044062
134Myotonia (HP:0002486)1.89785965
135Keratoconus (HP:0000563)1.88971421
136Increased corneal curvature (HP:0100692)1.88971421
137Postural tremor (HP:0002174)1.88273611
138Hypoglycemic coma (HP:0001325)1.88083858
139Poor suck (HP:0002033)1.87430136
140Abnormal autonomic nervous system physiology (HP:0012332)1.86757328
141Focal dystonia (HP:0004373)1.86647092
142Metabolic alkalosis (HP:0200114)1.86538173
143Torticollis (HP:0000473)1.86303237
144Hypoventilation (HP:0002791)1.85586218
145Increased CSF lactate (HP:0002490)1.85377134
146Vaginal atresia (HP:0000148)1.85200240
147Failure to thrive in infancy (HP:0001531)1.84610572
148Esotropia (HP:0000565)1.84469672
149Astrocytoma (HP:0009592)1.83537572
150Abnormality of the astrocytes (HP:0100707)1.83537572
151Lower limb asymmetry (HP:0100559)1.83490022
152Postural instability (HP:0002172)1.83274105
153Specific learning disability (HP:0001328)1.81895294
154Short hallux (HP:0010109)1.80905524
155Hyperactive renin-angiotensin system (HP:0000841)1.79123810
156Ventricular fibrillation (HP:0001663)1.76978100
157Abnormality of the 1st metacarpal (HP:0010009)1.76460849
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.75938265
159Tongue fasciculations (HP:0001308)1.74822299
160Aplasia/Hypoplasia of the hallux (HP:0008362)1.73583114
161Hyperaldosteronism (HP:0000859)1.71796474
162Papilledema (HP:0001085)1.71293138
163Conjunctival hamartoma (HP:0100780)1.71290159
164Pendular nystagmus (HP:0012043)1.71086166
165Abnormality of vitamin metabolism (HP:0100508)1.70247846
166Abnormality of ocular smooth pursuit (HP:0000617)1.70097347
167Thyroiditis (HP:0100646)1.69215800
168Dyskinesia (HP:0100660)1.68794640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.38230624
2MAP3K124.14041159
3EPHA43.70857160
4NTRK33.62038244
5MAP3K43.12628268
6MAP2K72.90855533
7MARK12.74886196
8PINK12.52995658
9MAP3K92.42823507
10STK392.39882124
11GRK12.39827832
12MAP4K22.25730286
13MINK12.18919047
14MST42.09854763
15DAPK22.09530554
16PLK22.09444642
17MAP2K42.09147736
18RIPK41.97622154
19TNIK1.90091030
20LMTK21.86637354
21DAPK11.86346493
22PNCK1.85678797
23CDK191.81325974
24MAPK131.73427571
25FGFR21.71891174
26NTRK21.70516789
27GRK51.62668952
28ARAF1.59507235
29NME11.58683818
30NTRK11.56879647
31STK38L1.51296009
32ADRBK21.49049076
33CAMKK21.47550143
34FES1.46887207
35NUAK11.36776436
36ACVR1B1.30565146
37MST1R1.28070845
38INSRR1.27629955
39SIK31.27347526
40CDK51.24786387
41MUSK1.12482500
42ADRBK11.12235190
43CAMK2A1.11794733
44EIF2AK31.10870801
45KSR11.10443057
46PRKCG1.08499498
47PRPF4B1.08228111
48PTK2B1.08034480
49MAP3K61.05704963
50CAMK2B0.99438157
51MYLK0.99355729
52OXSR10.97722032
53SGK20.96682528
54MET0.93662355
55GRK70.91499365
56SGK2230.90213831
57SGK4940.90213831
58CSNK1G20.89292241
59TSSK60.89087511
60PAK60.88966126
61AKT30.87558086
62KSR20.87473026
63MAPKAPK50.87093817
64WNK40.85881356
65PRKCE0.83929627
66TRPM70.83774513
67TRIM280.83657405
68STK240.82260715
69UHMK10.82074795
70SIK20.81136000
71BCR0.81047366
72CDK180.76165375
73TAOK30.75439944
74FRK0.75158135
75PRKG20.73959298
76CDK140.73946963
77PRKCI0.73556068
78BMPR20.72044943
79CAMKK10.72041534
80TAF10.71927185
81STK380.70428130
82WNK30.70004174
83STK30.69554038
84CAMK10.69303123
85FER0.69093456
86CDK150.67760495
87FGR0.66788033
88CSNK1G30.66237199
89PRKCH0.64536683
90PHKG20.63858798
91PHKG10.63858798
92TIE10.63638646
93MAP2K10.63545363
94MARK20.59999532
95DYRK1A0.58633114
96CDK11A0.58579726
97STK110.56967846
98MAP3K20.56776895
99RPS6KA20.55374160
100CAMK2D0.54319138
101LATS20.53989128
102ERBB30.53506286
103BMPR1B0.53274559
104EPHA20.52535806
105CSNK1A10.51269361
106DYRK20.49983650
107ZAK0.49622837
108MAP3K130.49463072
109NLK0.49274045
110CSNK1G10.48513590
111MKNK20.47868217
112CSNK1A1L0.46900238
113CSNK1D0.46758625
114NEK60.46014680
115HIPK20.45774437
116SGK10.43870054
117MATK0.43204821
118SGK30.43089423
119PAK30.42448335
120PRKAA10.41350560
121RET0.41017566
122TYRO30.40839046
123CAMK2G0.40809109
124EIF2AK20.40729913
125ROCK20.40530159
126PRKCZ0.40093898
127PRKCA0.39949399
128WNK10.39337695
129PRKG10.38390743
130MAPK120.38366994
131RAF10.36225233
132MAP2K60.36162200
133BRSK20.35989645
134PRKACA0.35747225
135DAPK30.35370439
136PDK10.34837942
137MAPK40.34534924
138CAMK40.33502224
139PIK3CA0.32116547
140FYN0.31993865

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.10114822
2Synaptic vesicle cycle_Homo sapiens_hsa047213.58470153
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.54887753
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85145900
5Collecting duct acid secretion_Homo sapiens_hsa049662.75385967
6Long-term potentiation_Homo sapiens_hsa047202.58598680
7Circadian entrainment_Homo sapiens_hsa047132.54272957
8GABAergic synapse_Homo sapiens_hsa047272.49079483
9Olfactory transduction_Homo sapiens_hsa047402.46424912
10Amphetamine addiction_Homo sapiens_hsa050312.41786154
11Morphine addiction_Homo sapiens_hsa050322.34339448
12Glutamatergic synapse_Homo sapiens_hsa047242.33126434
13Oxidative phosphorylation_Homo sapiens_hsa001902.23023898
14Dopaminergic synapse_Homo sapiens_hsa047282.18884926
15Taste transduction_Homo sapiens_hsa047422.18733920
16Serotonergic synapse_Homo sapiens_hsa047261.95318845
17Salivary secretion_Homo sapiens_hsa049701.94946098
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82554880
19Alzheimers disease_Homo sapiens_hsa050101.78529779
20Sulfur metabolism_Homo sapiens_hsa009201.77252663
21Cholinergic synapse_Homo sapiens_hsa047251.76006306
22Vibrio cholerae infection_Homo sapiens_hsa051101.72968163
23Insulin secretion_Homo sapiens_hsa049111.68571265
24Renin secretion_Homo sapiens_hsa049241.68321827
25Cocaine addiction_Homo sapiens_hsa050301.64983336
26Long-term depression_Homo sapiens_hsa047301.63330466
27Parkinsons disease_Homo sapiens_hsa050121.63081869
28Gastric acid secretion_Homo sapiens_hsa049711.58472795
29Vitamin B6 metabolism_Homo sapiens_hsa007501.58372607
30Protein export_Homo sapiens_hsa030601.58272353
31Calcium signaling pathway_Homo sapiens_hsa040201.56399632
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49625207
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44918830
34Cardiac muscle contraction_Homo sapiens_hsa042601.44916797
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44254370
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44202061
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39967542
38Oxytocin signaling pathway_Homo sapiens_hsa049211.39523595
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36042013
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29976112
41Axon guidance_Homo sapiens_hsa043601.26457648
42Huntingtons disease_Homo sapiens_hsa050161.24687455
43Selenocompound metabolism_Homo sapiens_hsa004501.22832791
44Caffeine metabolism_Homo sapiens_hsa002321.17859214
45Phototransduction_Homo sapiens_hsa047441.17640283
46GnRH signaling pathway_Homo sapiens_hsa049121.16983885
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16101830
48Gap junction_Homo sapiens_hsa045401.14179563
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13678371
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12390409
51Tryptophan metabolism_Homo sapiens_hsa003801.04565568
52Melanogenesis_Homo sapiens_hsa049161.03456434
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02792126
54cAMP signaling pathway_Homo sapiens_hsa040241.01623034
55ABC transporters_Homo sapiens_hsa020101.00621810
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98994484
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98186381
58Estrogen signaling pathway_Homo sapiens_hsa049150.95637978
59Mineral absorption_Homo sapiens_hsa049780.95549113
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95422513
61Nitrogen metabolism_Homo sapiens_hsa009100.95406237
62Ether lipid metabolism_Homo sapiens_hsa005650.95288075
63Histidine metabolism_Homo sapiens_hsa003400.92913188
64beta-Alanine metabolism_Homo sapiens_hsa004100.92446966
65Chemical carcinogenesis_Homo sapiens_hsa052040.89461291
66Retinol metabolism_Homo sapiens_hsa008300.87006686
67Linoleic acid metabolism_Homo sapiens_hsa005910.86351805
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.85432576
69ErbB signaling pathway_Homo sapiens_hsa040120.84481259
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83809592
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.83721527
72Rheumatoid arthritis_Homo sapiens_hsa053230.83269784
73Glioma_Homo sapiens_hsa052140.82085668
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81242127
75Propanoate metabolism_Homo sapiens_hsa006400.79565971
76Regulation of autophagy_Homo sapiens_hsa041400.78879298
77Bile secretion_Homo sapiens_hsa049760.76235729
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76141441
79Type II diabetes mellitus_Homo sapiens_hsa049300.76031731
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75265638
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69594182
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68745089
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68361134
84Thyroid hormone synthesis_Homo sapiens_hsa049180.68297513
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67975820
86Sphingolipid metabolism_Homo sapiens_hsa006000.67420109
87Folate biosynthesis_Homo sapiens_hsa007900.66385862
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65712603
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65186701
90Ovarian steroidogenesis_Homo sapiens_hsa049130.63961078
91African trypanosomiasis_Homo sapiens_hsa051430.60299827
92Type I diabetes mellitus_Homo sapiens_hsa049400.59531229
93Tight junction_Homo sapiens_hsa045300.59016083
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57199729
95Phagosome_Homo sapiens_hsa041450.55342252
96Peroxisome_Homo sapiens_hsa041460.55105828
97Pancreatic secretion_Homo sapiens_hsa049720.54420581
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54200559
99Dorso-ventral axis formation_Homo sapiens_hsa043200.53749134
100Oocyte meiosis_Homo sapiens_hsa041140.53568076
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51650342
102Glucagon signaling pathway_Homo sapiens_hsa049220.50904805
103Dilated cardiomyopathy_Homo sapiens_hsa054140.50601074
104Choline metabolism in cancer_Homo sapiens_hsa052310.49644768
105Ras signaling pathway_Homo sapiens_hsa040140.48602010
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48299125
107MAPK signaling pathway_Homo sapiens_hsa040100.47376679
108Alcoholism_Homo sapiens_hsa050340.46304199
109Glycerolipid metabolism_Homo sapiens_hsa005610.45794099
110Basal transcription factors_Homo sapiens_hsa030220.45327339
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.44524175
112Rap1 signaling pathway_Homo sapiens_hsa040150.44074924
113Prion diseases_Homo sapiens_hsa050200.41233330
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.40407499
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40292504
116Wnt signaling pathway_Homo sapiens_hsa043100.39347769
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38814472
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37391885
119RNA degradation_Homo sapiens_hsa030180.37387760
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.36027844
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.35446223
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35386328
123Hippo signaling pathway_Homo sapiens_hsa043900.35183232
124Melanoma_Homo sapiens_hsa052180.32820584
125Circadian rhythm_Homo sapiens_hsa047100.32425240
126VEGF signaling pathway_Homo sapiens_hsa043700.31521860
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29897485
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.29665203
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29519211
130Inositol phosphate metabolism_Homo sapiens_hsa005620.29101598
131Colorectal cancer_Homo sapiens_hsa052100.21451846
132Insulin signaling pathway_Homo sapiens_hsa049100.21160440
133Butanoate metabolism_Homo sapiens_hsa006500.20786371
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20189367
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18395894
136Renin-angiotensin system_Homo sapiens_hsa046140.18292652
137Pyruvate metabolism_Homo sapiens_hsa006200.17612038
138Endometrial cancer_Homo sapiens_hsa052130.17309099
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16827822

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