

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | response to pheromone (GO:0019236) | 6.32802772 |
| 2 | pyrimidine nucleobase catabolic process (GO:0006208) | 5.82443935 |
| 3 | cell migration in hindbrain (GO:0021535) | 5.33023597 |
| 4 | layer formation in cerebral cortex (GO:0021819) | 5.26146688 |
| 5 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.74559404 |
| 6 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.74332334 |
| 7 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.64747764 |
| 8 | synaptic vesicle maturation (GO:0016188) | 4.62569329 |
| 9 | locomotory exploration behavior (GO:0035641) | 4.40877853 |
| 10 | neuronal action potential propagation (GO:0019227) | 4.38864288 |
| 11 | nucleobase catabolic process (GO:0046113) | 4.38382219 |
| 12 | negative regulation of microtubule polymerization (GO:0031115) | 4.36206590 |
| 13 | neuron cell-cell adhesion (GO:0007158) | 4.34783004 |
| 14 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.34663939 |
| 15 | protein localization to synapse (GO:0035418) | 4.16936370 |
| 16 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.12569838 |
| 17 | vocalization behavior (GO:0071625) | 4.06431062 |
| 18 | neuron recognition (GO:0008038) | 4.04519050 |
| 19 | axonal fasciculation (GO:0007413) | 4.03337029 |
| 20 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.02950812 |
| 21 | dendritic spine morphogenesis (GO:0060997) | 3.94729792 |
| 22 | protoporphyrinogen IX metabolic process (GO:0046501) | 3.94507404 |
| 23 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.88829235 |
| 24 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.88220539 |
| 25 | positive regulation of fibroblast migration (GO:0010763) | 3.87278012 |
| 26 | dendrite morphogenesis (GO:0048813) | 3.85720022 |
| 27 | positive regulation of synapse maturation (GO:0090129) | 3.78096263 |
| 28 | regulation of synaptic vesicle transport (GO:1902803) | 3.73651785 |
| 29 | presynaptic membrane assembly (GO:0097105) | 3.73424255 |
| 30 | synaptic vesicle exocytosis (GO:0016079) | 3.67944575 |
| 31 | sodium ion export (GO:0071436) | 3.66963469 |
| 32 | presynaptic membrane organization (GO:0097090) | 3.64326425 |
| 33 | glutamate secretion (GO:0014047) | 3.61255145 |
| 34 | exploration behavior (GO:0035640) | 3.60824561 |
| 35 | granulocyte differentiation (GO:0030851) | 3.59837305 |
| 36 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.57806276 |
| 37 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.55815813 |
| 38 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.55136912 |
| 39 | neuron-neuron synaptic transmission (GO:0007270) | 3.53730735 |
| 40 | neurotransmitter transport (GO:0006836) | 3.53612821 |
| 41 | protoporphyrinogen IX biosynthetic process (GO:0006782) | 3.53359288 |
| 42 | positive regulation of membrane potential (GO:0045838) | 3.50106411 |
| 43 | positive regulation of dendritic spine development (GO:0060999) | 3.48645984 |
| 44 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.47047023 |
| 45 | transmission of nerve impulse (GO:0019226) | 3.46155976 |
| 46 | porphyrin-containing compound biosynthetic process (GO:0006779) | 3.45094988 |
| 47 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.44989000 |
| 48 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.42411274 |
| 49 | neuromuscular synaptic transmission (GO:0007274) | 3.41567736 |
| 50 | negative regulation of oligodendrocyte differentiation (GO:0048715) | 3.40949066 |
| 51 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.40759700 |
| 52 | regulation of postsynaptic membrane potential (GO:0060078) | 3.35067938 |
| 53 | erythrocyte maturation (GO:0043249) | 3.35003152 |
| 54 | regulation of synapse structural plasticity (GO:0051823) | 3.34946090 |
| 55 | regulation of neurotransmitter levels (GO:0001505) | 3.33111609 |
| 56 | cell communication by electrical coupling (GO:0010644) | 3.30322064 |
| 57 | platelet formation (GO:0030220) | 3.27728324 |
| 58 | establishment of nucleus localization (GO:0040023) | 3.25149716 |
| 59 | postsynaptic membrane organization (GO:0001941) | 3.24527735 |
| 60 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.23868257 |
| 61 | mitochondrion transport along microtubule (GO:0047497) | 3.23868257 |
| 62 | hippocampus development (GO:0021766) | 3.23512060 |
| 63 | axon extension (GO:0048675) | 3.22612745 |
| 64 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.21040441 |
| 65 | mechanosensory behavior (GO:0007638) | 3.19496443 |
| 66 | neurotransmitter secretion (GO:0007269) | 3.18609019 |
| 67 | dendritic spine organization (GO:0097061) | 3.17012625 |
| 68 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.14969786 |
| 69 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.13839475 |
| 70 | L-amino acid import (GO:0043092) | 3.11949596 |
| 71 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.10914869 |
| 72 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.10743910 |
| 73 | establishment of mitochondrion localization (GO:0051654) | 3.09908871 |
| 74 | regulation of neurotransmitter transport (GO:0051588) | 3.09456694 |
| 75 | membrane depolarization (GO:0051899) | 3.08430262 |
| 76 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.08212753 |
| 77 | synaptic transmission, glutamatergic (GO:0035249) | 3.08185248 |
| 78 | tetrapyrrole biosynthetic process (GO:0033014) | 3.06311655 |
| 79 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.06217572 |
| 80 | negative regulation of organelle assembly (GO:1902116) | 3.06018739 |
| 81 | clathrin coat assembly (GO:0048268) | 3.05888230 |
| 82 | central nervous system myelination (GO:0022010) | 3.05320007 |
| 83 | axon ensheathment in central nervous system (GO:0032291) | 3.05320007 |
| 84 | proline transport (GO:0015824) | 3.05025997 |
| 85 | neuronal ion channel clustering (GO:0045161) | 3.03331769 |
| 86 | glutamate receptor signaling pathway (GO:0007215) | 3.02830534 |
| 87 | auditory behavior (GO:0031223) | 3.02364252 |
| 88 | actin filament capping (GO:0051693) | 3.00689526 |
| 89 | positive regulation of neurotransmitter transport (GO:0051590) | 2.99200025 |
| 90 | cerebellar granule cell differentiation (GO:0021707) | 2.97649064 |
| 91 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.96227123 |
| 92 | heart valve formation (GO:0003188) | 2.96162019 |
| 93 | axon cargo transport (GO:0008088) | 2.95571731 |
| 94 | cell differentiation in hindbrain (GO:0021533) | 2.94959363 |
| 95 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.94693736 |
| 96 | dopamine receptor signaling pathway (GO:0007212) | 2.93811499 |
| 97 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.93174504 |
| 98 | central nervous system neuron axonogenesis (GO:0021955) | 2.92827279 |
| 99 | cerebellar Purkinje cell layer development (GO:0021680) | 2.92163664 |
| 100 | glycine transport (GO:0015816) | 2.89786815 |
| 101 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.89786654 |
| 102 | positive regulation of synapse assembly (GO:0051965) | 2.88891389 |
| 103 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.88762397 |
| 104 | long-term memory (GO:0007616) | 2.87985973 |
| 105 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.87520199 |
| 106 | amino acid import (GO:0043090) | 2.87511469 |
| 107 | adult walking behavior (GO:0007628) | 2.87476160 |
| 108 | negative regulation of catenin import into nucleus (GO:0035414) | 2.86849274 |
| 109 | regulation of synaptic plasticity (GO:0048167) | 2.85916165 |
| 110 | embryonic hemopoiesis (GO:0035162) | 2.85798707 |
| 111 | synaptic vesicle endocytosis (GO:0048488) | 2.85283068 |
| 112 | synapse organization (GO:0050808) | 2.84984349 |
| 113 | cerebellum development (GO:0021549) | 2.84572076 |
| 114 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.83342645 |
| 115 | potassium ion import (GO:0010107) | 2.82738321 |
| 116 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.82519118 |
| 117 | atrioventricular valve morphogenesis (GO:0003181) | 2.82292764 |
| 118 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.81613562 |
| 119 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.81548064 |
| 120 | response to auditory stimulus (GO:0010996) | 2.80100922 |
| 121 | potassium ion homeostasis (GO:0055075) | 2.79986726 |
| 122 | neuron projection extension (GO:1990138) | 2.79698836 |
| 123 | intraspecies interaction between organisms (GO:0051703) | 2.79662661 |
| 124 | innervation (GO:0060384) | 2.79323887 |
| 125 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316 | 2.79211686 |
| 126 | detection of temperature stimulus involved in sensory perception (GO:0050961) | 2.78960812 |
| 127 | detection of temperature stimulus involved in sensory perception of pain (GO:0050965) | 2.78960812 |
| 128 | neuromuscular process controlling balance (GO:0050885) | 2.77980454 |
| 129 | regulation of synapse maturation (GO:0090128) | 2.77881850 |
| 130 | synapse assembly (GO:0007416) | 2.77812466 |
| 131 | gamma-aminobutyric acid transport (GO:0015812) | 2.74828040 |
| 132 | activation of protein kinase A activity (GO:0034199) | 2.74153908 |
| 133 | regulation of neurotransmitter secretion (GO:0046928) | 2.73157608 |
| 134 | membrane depolarization during action potential (GO:0086010) | 2.71973175 |
| 135 | erythrocyte development (GO:0048821) | 2.70916423 |
| 136 | regulation of vesicle fusion (GO:0031338) | 2.70808958 |
| 137 | mitochondrial fragmentation involved in apoptotic process (GO:0043653) | 2.68641104 |
| 138 | cellular potassium ion homeostasis (GO:0030007) | 2.68618188 |
| 139 | regulation of axon extension (GO:0030516) | 2.68541777 |
| 140 | detection of temperature stimulus (GO:0016048) | 2.67800692 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.43720167 |
| 2 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 3.19959341 |
| 3 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.12013179 |
| 4 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.98186250 |
| 5 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.80053972 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.80053972 |
| 7 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.79371843 |
| 8 | * EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.76384781 |
| 9 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.75362938 |
| 10 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.72541045 |
| 11 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.65594701 |
| 12 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.60644303 |
| 13 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.60349329 |
| 14 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.50067622 |
| 15 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.48538960 |
| 16 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.46313969 |
| 17 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.43647066 |
| 18 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.42237896 |
| 19 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.39348245 |
| 20 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.27154432 |
| 21 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.23497569 |
| 22 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 2.22535939 |
| 23 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.22096940 |
| 24 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.15064818 |
| 25 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.14657377 |
| 26 | * EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 2.12223801 |
| 27 | * KDM2B_26808549_Chip-Seq_K562_Human | 2.10653692 |
| 28 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.08707980 |
| 29 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.02838527 |
| 30 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.01751630 |
| 31 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.94643893 |
| 32 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.94499996 |
| 33 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.92747745 |
| 34 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.87252467 |
| 35 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.86668438 |
| 36 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.86663326 |
| 37 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.84424838 |
| 38 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.82864114 |
| 39 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.75605968 |
| 40 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.72652173 |
| 41 | * RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.68829160 |
| 42 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.65238602 |
| 43 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.63593334 |
| 44 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.61538597 |
| 45 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.61437556 |
| 46 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.61100187 |
| 47 | * GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.56056047 |
| 48 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.55805721 |
| 49 | GATA1_19941826_ChIP-Seq_K562_Human | 1.55626229 |
| 50 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.49899022 |
| 51 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.46196847 |
| 52 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.44472834 |
| 53 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.38493002 |
| 54 | * KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 1.35121755 |
| 55 | * KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.34626742 |
| 56 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.33243580 |
| 57 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.32186049 |
| 58 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.30616545 |
| 59 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.30541447 |
| 60 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.28653378 |
| 61 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.27378259 |
| 62 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.26449092 |
| 63 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.24900296 |
| 64 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.23998767 |
| 65 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.19631183 |
| 66 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.18053092 |
| 67 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.17740610 |
| 68 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.17194614 |
| 69 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.17077992 |
| 70 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.14041087 |
| 71 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.08188319 |
| 72 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.05720518 |
| 73 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.05521671 |
| 74 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.04557868 |
| 75 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.03190595 |
| 76 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.02585057 |
| 77 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.02559384 |
| 78 | AR_19668381_ChIP-Seq_PC3_Human | 1.01063968 |
| 79 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.99146737 |
| 80 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.98799648 |
| 81 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.96289949 |
| 82 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.95944223 |
| 83 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.95863685 |
| 84 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.95563516 |
| 85 | MYC_22102868_ChIP-Seq_BL_Human | 0.95408478 |
| 86 | SOX3_22085726_ChIP-Seq_NPCs_Mouse | 0.95349754 |
| 87 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.95191502 |
| 88 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94745711 |
| 89 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.94372122 |
| 90 | P68_20966046_ChIP-Seq_HELA_Human | 0.93105812 |
| 91 | * TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.92955552 |
| 92 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.92910635 |
| 93 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.90732917 |
| 94 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89358355 |
| 95 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.88933117 |
| 96 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.87806733 |
| 97 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.87767163 |
| 98 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.86857708 |
| 99 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.86792043 |
| 100 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.86146071 |
| 101 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.86040564 |
| 102 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.85977754 |
| 103 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.85953034 |
| 104 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.85941903 |
| 105 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.85755010 |
| 106 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.84112704 |
| 107 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.83710392 |
| 108 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.83602905 |
| 109 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.83562326 |
| 110 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.83370402 |
| 111 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.83251573 |
| 112 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 0.83142823 |
| 113 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.82161904 |
| 114 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.82161904 |
| 115 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.82007814 |
| 116 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.81962574 |
| 117 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.81554645 |
| 118 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.81480414 |
| 119 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.81240160 |
| 120 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 0.80972223 |
| 121 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.80581701 |
| 122 | * NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.78906060 |
| 123 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.78070585 |
| 124 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.77576579 |
| 125 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.77333897 |
| 126 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.76043235 |
| 127 | MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse | 0.75604728 |
| 128 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.75498887 |
| 129 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.75066887 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 4.83911669 |
| 2 | MP0001968_abnormal_touch/_nociception | 3.19847952 |
| 3 | MP0005423_abnormal_somatic_nervous | 3.18544881 |
| 4 | MP0003880_abnormal_central_pattern | 3.06376012 |
| 5 | MP0004270_analgesia | 2.99600007 |
| 6 | MP0003635_abnormal_synaptic_transmissio | 2.94774689 |
| 7 | MP0003656_abnormal_erythrocyte_physiolo | 2.93093166 |
| 8 | MP0002735_abnormal_chemical_nociception | 2.84021297 |
| 9 | MP0006276_abnormal_autonomic_nervous | 2.81036523 |
| 10 | MP0000778_abnormal_nervous_system | 2.73862816 |
| 11 | MP0002733_abnormal_thermal_nociception | 2.64471532 |
| 12 | MP0002734_abnormal_mechanical_nocicepti | 2.61085883 |
| 13 | MP0003122_maternal_imprinting | 2.57459332 |
| 14 | MP0002736_abnormal_nociception_after | 2.53811248 |
| 15 | MP0002063_abnormal_learning/memory/cond | 2.43747956 |
| 16 | MP0002184_abnormal_innervation | 2.27752662 |
| 17 | MP0005645_abnormal_hypothalamus_physiol | 2.21508838 |
| 18 | MP0004858_abnormal_nervous_system | 2.16329983 |
| 19 | MP0001970_abnormal_pain_threshold | 2.15492035 |
| 20 | MP0004811_abnormal_neuron_physiology | 2.05916856 |
| 21 | MP0004147_increased_porphyrin_level | 2.05773449 |
| 22 | MP0009745_abnormal_behavioral_response | 2.02777193 |
| 23 | MP0000955_abnormal_spinal_cord | 1.98069712 |
| 24 | MP0002064_seizures | 1.95974253 |
| 25 | MP0002822_catalepsy | 1.88407725 |
| 26 | MP0009046_muscle_twitch | 1.88291571 |
| 27 | MP0005394_taste/olfaction_phenotype | 1.87695763 |
| 28 | MP0005499_abnormal_olfactory_system | 1.87695763 |
| 29 | MP0008789_abnormal_olfactory_epithelium | 1.82580682 |
| 30 | MP0001440_abnormal_grooming_behavior | 1.80780197 |
| 31 | MP0002653_abnormal_ependyma_morphology | 1.78860959 |
| 32 | MP0002067_abnormal_sensory_capabilities | 1.75444510 |
| 33 | MP0002557_abnormal_social/conspecific_i | 1.74256540 |
| 34 | MP0002572_abnormal_emotion/affect_behav | 1.74160490 |
| 35 | MP0002272_abnormal_nervous_system | 1.65205052 |
| 36 | MP0001188_hyperpigmentation | 1.64928698 |
| 37 | MP0004885_abnormal_endolymph | 1.64829397 |
| 38 | MP0002882_abnormal_neuron_morphology | 1.61812591 |
| 39 | MP0001986_abnormal_taste_sensitivity | 1.55020790 |
| 40 | MP0008569_lethality_at_weaning | 1.54354019 |
| 41 | MP0001486_abnormal_startle_reflex | 1.54327633 |
| 42 | MP0001984_abnormal_olfaction | 1.52364481 |
| 43 | MP0001501_abnormal_sleep_pattern | 1.43296537 |
| 44 | MP0003879_abnormal_hair_cell | 1.42270971 |
| 45 | MP0002152_abnormal_brain_morphology | 1.39795800 |
| 46 | MP0001905_abnormal_dopamine_level | 1.38918192 |
| 47 | MP0003329_amyloid_beta_deposits | 1.37797886 |
| 48 | MP0003861_abnormal_nervous_system | 1.32373565 |
| 49 | MP0008961_abnormal_basal_metabolism | 1.29114488 |
| 50 | MP0000537_abnormal_urethra_morphology | 1.29031703 |
| 51 | MP0002751_abnormal_autonomic_nervous | 1.27363782 |
| 52 | MP0005409_darkened_coat_color | 1.26421397 |
| 53 | MP0003121_genomic_imprinting | 1.24014057 |
| 54 | MP0000631_abnormal_neuroendocrine_gland | 1.23782750 |
| 55 | MP0000569_abnormal_digit_pigmentation | 1.22814814 |
| 56 | MP0003787_abnormal_imprinting | 1.22624057 |
| 57 | MP0002066_abnormal_motor_capabilities/c | 1.19888201 |
| 58 | MP0004924_abnormal_behavior | 1.17420920 |
| 59 | MP0005386_behavior/neurological_phenoty | 1.17420920 |
| 60 | MP0003123_paternal_imprinting | 1.14599336 |
| 61 | MP0004742_abnormal_vestibular_system | 1.14190503 |
| 62 | MP0003633_abnormal_nervous_system | 1.12605378 |
| 63 | MP0010030_abnormal_orbit_morphology | 1.09913105 |
| 64 | MP0002102_abnormal_ear_morphology | 1.09752607 |
| 65 | MP0003283_abnormal_digestive_organ | 1.09563764 |
| 66 | MP0001502_abnormal_circadian_rhythm | 1.09038129 |
| 67 | MP0002752_abnormal_somatic_nervous | 1.08714923 |
| 68 | MP0003631_nervous_system_phenotype | 1.07156637 |
| 69 | MP0001177_atelectasis | 1.06387847 |
| 70 | MP0002909_abnormal_adrenal_gland | 1.03639776 |
| 71 | MP0000534_abnormal_ureter_morphology | 0.99571481 |
| 72 | MP0001963_abnormal_hearing_physiology | 0.99090424 |
| 73 | MP0008995_early_reproductive_senescence | 0.96066443 |
| 74 | MP0001348_abnormal_lacrimal_gland | 0.95933833 |
| 75 | MP0005646_abnormal_pituitary_gland | 0.95651482 |
| 76 | MP0006292_abnormal_olfactory_placode | 0.94998574 |
| 77 | MP0005187_abnormal_penis_morphology | 0.94676626 |
| 78 | MP0009780_abnormal_chondrocyte_physiolo | 0.92208307 |
| 79 | MP0001299_abnormal_eye_distance/ | 0.91771774 |
| 80 | MP0003632_abnormal_nervous_system | 0.90233590 |
| 81 | MP0008770_decreased_survivor_rate | 0.89902856 |
| 82 | MP0008872_abnormal_physiological_respon | 0.89324362 |
| 83 | MP0005377_hearing/vestibular/ear_phenot | 0.89170301 |
| 84 | MP0003878_abnormal_ear_physiology | 0.89170301 |
| 85 | MP0000026_abnormal_inner_ear | 0.87315236 |
| 86 | MP0000049_abnormal_middle_ear | 0.87254348 |
| 87 | MP0004130_abnormal_muscle_cell | 0.87217274 |
| 88 | MP0001529_abnormal_vocalization | 0.87077260 |
| 89 | MP0002638_abnormal_pupillary_reflex | 0.87040501 |
| 90 | MP0001270_distended_abdomen | 0.86731372 |
| 91 | MP0005171_absent_coat_pigmentation | 0.85878417 |
| 92 | MP0003942_abnormal_urinary_system | 0.85543305 |
| 93 | MP0004133_heterotaxia | 0.84562688 |
| 94 | MP0002081_perinatal_lethality | 0.83268937 |
| 95 | MP0000920_abnormal_myelination | 0.83013623 |
| 96 | MP0003690_abnormal_glial_cell | 0.82578687 |
| 97 | MP0006072_abnormal_retinal_apoptosis | 0.82438750 |
| 98 | MP0003137_abnormal_impulse_conducting | 0.81798234 |
| 99 | MP0004145_abnormal_muscle_electrophysio | 0.81322256 |
| 100 | MP0002089_abnormal_postnatal_growth/wei | 0.81041411 |
| 101 | MP0002234_abnormal_pharynx_morphology | 0.81001265 |
| 102 | MP0003119_abnormal_digestive_system | 0.79812783 |
| 103 | MP0002069_abnormal_eating/drinking_beha | 0.78547588 |
| 104 | MP0002229_neurodegeneration | 0.78469286 |
| 105 | MP0004142_abnormal_muscle_tone | 0.78359603 |
| 106 | MP0003938_abnormal_ear_development | 0.75319371 |
| 107 | MP0005623_abnormal_meninges_morphology | 0.74651324 |
| 108 | MP0001485_abnormal_pinna_reflex | 0.71850562 |
| 109 | MP0005167_abnormal_blood-brain_barrier | 0.71605049 |
| 110 | MP0000751_myopathy | 0.71409024 |
| 111 | MP0010769_abnormal_survival | 0.69561923 |
| 112 | MP0005397_hematopoietic_system_phenotyp | 0.68750374 |
| 113 | MP0001545_abnormal_hematopoietic_system | 0.68750374 |
| 114 | MP0008874_decreased_physiological_sensi | 0.68728944 |
| 115 | MP0003634_abnormal_glial_cell | 0.68532295 |
| 116 | MP0005551_abnormal_eye_electrophysiolog | 0.68456235 |
| 117 | MP0001943_abnormal_respiration | 0.68191237 |
| 118 | MP0003385_abnormal_body_wall | 0.67690496 |
| 119 | MP0003136_yellow_coat_color | 0.66582669 |
| 120 | MP0010768_mortality/aging | 0.66047483 |
| 121 | MP0010770_preweaning_lethality | 0.65617654 |
| 122 | MP0002082_postnatal_lethality | 0.65617654 |
| 123 | MP0010386_abnormal_urinary_bladder | 0.64811014 |
| 124 | MP0005083_abnormal_biliary_tract | 0.63109872 |
| 125 | MP0002249_abnormal_larynx_morphology | 0.62710433 |
| 126 | MP0003315_abnormal_perineum_morphology | 0.62217711 |
| 127 | MP0005253_abnormal_eye_physiology | 0.61816113 |
| 128 | MP0004085_abnormal_heartbeat | 0.59011498 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 5.63617324 |
| 2 | Insomnia (HP:0100785) | 4.56696907 |
| 3 | Poikilocytosis (HP:0004447) | 4.40165301 |
| 4 | Myokymia (HP:0002411) | 4.20495564 |
| 5 | Atonic seizures (HP:0010819) | 4.11557631 |
| 6 | Reticulocytosis (HP:0001923) | 3.91743774 |
| 7 | Failure to thrive in infancy (HP:0001531) | 3.87900016 |
| 8 | Focal seizures (HP:0007359) | 3.77182915 |
| 9 | Acanthocytosis (HP:0001927) | 3.62412156 |
| 10 | Visual hallucinations (HP:0002367) | 3.51794405 |
| 11 | Annular pancreas (HP:0001734) | 3.48912404 |
| 12 | Supranuclear gaze palsy (HP:0000605) | 3.45116702 |
| 13 | Hyperacusis (HP:0010780) | 3.26949597 |
| 14 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.20484834 |
| 15 | Akinesia (HP:0002304) | 3.18823564 |
| 16 | Ankle clonus (HP:0011448) | 3.05305570 |
| 17 | Limb dystonia (HP:0002451) | 3.00970131 |
| 18 | Neurofibrillary tangles (HP:0002185) | 2.99172489 |
| 19 | Progressive cerebellar ataxia (HP:0002073) | 2.97798833 |
| 20 | Epileptic encephalopathy (HP:0200134) | 2.88711646 |
| 21 | Short middle phalanx of the 5th finger (HP:0004220) | 2.86662721 |
| 22 | Obstructive sleep apnea (HP:0002870) | 2.83188336 |
| 23 | Focal motor seizures (HP:0011153) | 2.82665361 |
| 24 | Turricephaly (HP:0000262) | 2.79081613 |
| 25 | Depression (HP:0000716) | 2.78568606 |
| 26 | Hemiparesis (HP:0001269) | 2.77895752 |
| 27 | Polyphagia (HP:0002591) | 2.76154105 |
| 28 | Cortical dysplasia (HP:0002539) | 2.75797802 |
| 29 | Large eyes (HP:0001090) | 2.73317128 |
| 30 | Hemiplegia (HP:0002301) | 2.73098997 |
| 31 | Action tremor (HP:0002345) | 2.72303418 |
| 32 | Mutism (HP:0002300) | 2.63881996 |
| 33 | Elfin facies (HP:0004428) | 2.61672503 |
| 34 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.57918406 |
| 35 | Craniofacial dystonia (HP:0012179) | 2.56815106 |
| 36 | Amyotrophic lateral sclerosis (HP:0007354) | 2.55762665 |
| 37 | Poor eye contact (HP:0000817) | 2.54360719 |
| 38 | Fetal akinesia sequence (HP:0001989) | 2.52514247 |
| 39 | Hypoventilation (HP:0002791) | 2.52405901 |
| 40 | Agitation (HP:0000713) | 2.49035715 |
| 41 | Megalencephaly (HP:0001355) | 2.48913473 |
| 42 | Febrile seizures (HP:0002373) | 2.48783043 |
| 43 | Cerebral inclusion bodies (HP:0100314) | 2.48159232 |
| 44 | Amblyopia (HP:0000646) | 2.48113772 |
| 45 | Hypoplasia of the brainstem (HP:0002365) | 2.46019264 |
| 46 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.46019264 |
| 47 | Diplopia (HP:0000651) | 2.43314204 |
| 48 | Abnormality of binocular vision (HP:0011514) | 2.43314204 |
| 49 | Protruding tongue (HP:0010808) | 2.42151123 |
| 50 | Postural instability (HP:0002172) | 2.40016851 |
| 51 | Absent speech (HP:0001344) | 2.39363213 |
| 52 | Renal duplication (HP:0000075) | 2.35325912 |
| 53 | Abnormal eating behavior (HP:0100738) | 2.32425214 |
| 54 | Abnormality of the lower motor neuron (HP:0002366) | 2.29966246 |
| 55 | Lower limb muscle weakness (HP:0007340) | 2.29811653 |
| 56 | Sacral dimple (HP:0000960) | 2.28691074 |
| 57 | Truncal ataxia (HP:0002078) | 2.28118867 |
| 58 | Termporal pattern (HP:0011008) | 2.24928118 |
| 59 | Insidious onset (HP:0003587) | 2.24928118 |
| 60 | Renovascular hypertension (HP:0100817) | 2.23764846 |
| 61 | Generalized hypotonia (HP:0001290) | 2.23273404 |
| 62 | Impaired social interactions (HP:0000735) | 2.22901071 |
| 63 | Abnormal social behavior (HP:0012433) | 2.22901071 |
| 64 | Pointed chin (HP:0000307) | 2.21324574 |
| 65 | Overriding aorta (HP:0002623) | 2.19982711 |
| 66 | Sporadic (HP:0003745) | 2.18067334 |
| 67 | Dysmetria (HP:0001310) | 2.17034723 |
| 68 | Lissencephaly (HP:0001339) | 2.16477142 |
| 69 | Hyperventilation (HP:0002883) | 2.15803314 |
| 70 | Petechiae (HP:0000967) | 2.14941574 |
| 71 | Broad palm (HP:0001169) | 2.14895035 |
| 72 | Pachygyria (HP:0001302) | 2.14603462 |
| 73 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.14351491 |
| 74 | Esotropia (HP:0000565) | 2.13744966 |
| 75 | Cerebral hypomyelination (HP:0006808) | 2.13523437 |
| 76 | Generalized tonic-clonic seizures (HP:0002069) | 2.12447783 |
| 77 | Drooling (HP:0002307) | 2.12134074 |
| 78 | Excessive salivation (HP:0003781) | 2.12134074 |
| 79 | Peripheral hypomyelination (HP:0007182) | 2.07268987 |
| 80 | Intention tremor (HP:0002080) | 2.07140344 |
| 81 | Sleep apnea (HP:0010535) | 2.06640006 |
| 82 | Impaired smooth pursuit (HP:0007772) | 2.04857732 |
| 83 | Stereotypic behavior (HP:0000733) | 2.03481436 |
| 84 | Absence seizures (HP:0002121) | 2.03119516 |
| 85 | Papilledema (HP:0001085) | 2.02632909 |
| 86 | Genetic anticipation (HP:0003743) | 2.01691030 |
| 87 | Hypercortisolism (HP:0001578) | 2.01074871 |
| 88 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 2.00030735 |
| 89 | Clonus (HP:0002169) | 1.99101619 |
| 90 | Polycythemia (HP:0001901) | 1.98665980 |
| 91 | Abnormality of reticulocytes (HP:0004312) | 1.98394688 |
| 92 | Status epilepticus (HP:0002133) | 1.98310560 |
| 93 | Torticollis (HP:0000473) | 1.96907110 |
| 94 | Short 5th finger (HP:0009237) | 1.95376637 |
| 95 | Broad-based gait (HP:0002136) | 1.95269954 |
| 96 | Urinary urgency (HP:0000012) | 1.94728030 |
| 97 | Anxiety (HP:0000739) | 1.93663692 |
| 98 | Abnormality of the corticospinal tract (HP:0002492) | 1.93174089 |
| 99 | Spastic tetraplegia (HP:0002510) | 1.89163605 |
| 100 | EEG with generalized epileptiform discharges (HP:0011198) | 1.88127933 |
| 101 | Neoplasm of the heart (HP:0100544) | 1.88027652 |
| 102 | Shallow orbits (HP:0000586) | 1.87483458 |
| 103 | Myotonia (HP:0002486) | 1.86257506 |
| 104 | Flat cornea (HP:0007720) | 1.86004786 |
| 105 | Coronal craniosynostosis (HP:0004440) | 1.85313321 |
| 106 | Hypsarrhythmia (HP:0002521) | 1.83476553 |
| 107 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.82741206 |
| 108 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.82741206 |
| 109 | Complete atrioventricular canal defect (HP:0001674) | 1.80897743 |
| 110 | Dialeptic seizures (HP:0011146) | 1.80412846 |
| 111 | Narrow nasal bridge (HP:0000446) | 1.80290276 |
| 112 | Apathy (HP:0000741) | 1.79643583 |
| 113 | Epileptiform EEG discharges (HP:0011182) | 1.79141401 |
| 114 | Morphological abnormality of the middle ear (HP:0008609) | 1.78388526 |
| 115 | Aqueductal stenosis (HP:0002410) | 1.78169389 |
| 116 | Incomplete penetrance (HP:0003829) | 1.77956669 |
| 117 | Specific learning disability (HP:0001328) | 1.77318954 |
| 118 | Focal dystonia (HP:0004373) | 1.77276430 |
| 119 | Spastic gait (HP:0002064) | 1.77132008 |
| 120 | Precocious puberty (HP:0000826) | 1.76737595 |
| 121 | Retinal dysplasia (HP:0007973) | 1.76710116 |
| 122 | Lower limb amyotrophy (HP:0007210) | 1.76036447 |
| 123 | Shoulder girdle muscle weakness (HP:0003547) | 1.75793475 |
| 124 | Rapidly progressive (HP:0003678) | 1.75378915 |
| 125 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.75368239 |
| 126 | Open mouth (HP:0000194) | 1.73805928 |
| 127 | Bowel diverticulosis (HP:0005222) | 1.73307665 |
| 128 | Heterotopia (HP:0002282) | 1.72392052 |
| 129 | Bradykinesia (HP:0002067) | 1.71909595 |
| 130 | Exotropia (HP:0000577) | 1.71423130 |
| 131 | Atrioventricular canal defect (HP:0006695) | 1.71298745 |
| 132 | Broad distal phalanx of finger (HP:0009836) | 1.71261759 |
| 133 | Progressive inability to walk (HP:0002505) | 1.71004845 |
| 134 | Spinal canal stenosis (HP:0003416) | 1.70996968 |
| 135 | Hypoplasia of the corpus callosum (HP:0002079) | 1.70889427 |
| 136 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.70798601 |
| 137 | Polymicrogyria (HP:0002126) | 1.70782391 |
| 138 | Neuronal loss in central nervous system (HP:0002529) | 1.69775241 |
| 139 | Bronchomalacia (HP:0002780) | 1.68888194 |
| 140 | Megalocornea (HP:0000485) | 1.68063075 |
| 141 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.66789317 |
| 142 | Short 4th metacarpal (HP:0010044) | 1.66789317 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 5.81193567 |
| 2 | MAP3K9 | 3.02919712 |
| 3 | MINK1 | 2.63441912 |
| 4 | NTRK3 | 2.42688459 |
| 5 | MAPK13 | 2.25710988 |
| 6 | MAP3K4 | 2.24343334 |
| 7 | SIK2 | 2.23943788 |
| 8 | NTRK2 | 2.21740541 |
| 9 | DYRK2 | 2.20193043 |
| 10 | UHMK1 | 2.19760334 |
| 11 | PAK6 | 2.11684959 |
| 12 | KSR1 | 2.08016631 |
| 13 | EPHB2 | 2.01902409 |
| 14 | ICK | 1.89198525 |
| 15 | MAP3K10 | 1.86805532 |
| 16 | PHKG1 | 1.85410563 |
| 17 | PHKG2 | 1.85410563 |
| 18 | MAP2K7 | 1.85373142 |
| 19 | DAPK2 | 1.69589301 |
| 20 | NTRK1 | 1.59377224 |
| 21 | CDK19 | 1.51461534 |
| 22 | EEF2K | 1.47755529 |
| 23 | RPS6KA2 | 1.46328562 |
| 24 | TAOK1 | 1.45629358 |
| 25 | CDK5 | 1.40609361 |
| 26 | TRIB3 | 1.36472101 |
| 27 | SIK3 | 1.33647176 |
| 28 | MAP2K4 | 1.33636015 |
| 29 | PLK2 | 1.30016522 |
| 30 | RET | 1.29584024 |
| 31 | ERBB2 | 1.25781488 |
| 32 | CDK14 | 1.25565336 |
| 33 | LIMK1 | 1.24198836 |
| 34 | CDK18 | 1.22774083 |
| 35 | ERBB3 | 1.22442103 |
| 36 | PKN1 | 1.22401466 |
| 37 | KSR2 | 1.19635489 |
| 38 | CDK15 | 1.17136535 |
| 39 | CAMKK1 | 1.16026282 |
| 40 | WNK3 | 1.14270166 |
| 41 | LATS2 | 1.13046275 |
| 42 | CDK11A | 1.09815850 |
| 43 | GRK5 | 1.09321316 |
| 44 | LMTK2 | 1.05092641 |
| 45 | MAP3K2 | 1.01939034 |
| 46 | PINK1 | 1.00772053 |
| 47 | CAMK2B | 0.98928707 |
| 48 | RIPK1 | 0.98103903 |
| 49 | MARK2 | 0.96116936 |
| 50 | SGK2 | 0.96032640 |
| 51 | MAP3K12 | 0.95455881 |
| 52 | SCYL2 | 0.94647710 |
| 53 | PRKCZ | 0.92834508 |
| 54 | BCR | 0.92553466 |
| 55 | DYRK1A | 0.90988959 |
| 56 | CAMK2A | 0.87640593 |
| 57 | MAPK15 | 0.87403139 |
| 58 | IRAK2 | 0.87392646 |
| 59 | TYRO3 | 0.86318013 |
| 60 | DYRK3 | 0.86113416 |
| 61 | SGK223 | 0.84374439 |
| 62 | SGK494 | 0.84374439 |
| 63 | PRKCG | 0.84036968 |
| 64 | BRSK1 | 0.82138449 |
| 65 | CSNK1G2 | 0.81611275 |
| 66 | ALK | 0.81042510 |
| 67 | PDGFRA | 0.78883941 |
| 68 | WNK4 | 0.77155574 |
| 69 | TNIK | 0.77052359 |
| 70 | DDR2 | 0.76287393 |
| 71 | PAK3 | 0.74356979 |
| 72 | WNK1 | 0.74003264 |
| 73 | BRD4 | 0.73652418 |
| 74 | PKN2 | 0.72299494 |
| 75 | STK11 | 0.71271807 |
| 76 | CAMKK2 | 0.70881385 |
| 77 | PRKD3 | 0.70606223 |
| 78 | FGFR2 | 0.70324848 |
| 79 | NEK1 | 0.69324209 |
| 80 | STK38 | 0.68182591 |
| 81 | CAMK2G | 0.67463860 |
| 82 | DYRK1B | 0.64493695 |
| 83 | EPHA3 | 0.64162458 |
| 84 | CDC42BPA | 0.62073840 |
| 85 | ARAF | 0.61020520 |
| 86 | ROCK1 | 0.59189802 |
| 87 | CASK | 0.58938474 |
| 88 | CSNK1G3 | 0.57924148 |
| 89 | MAPK9 | 0.57923982 |
| 90 | OXSR1 | 0.56970321 |
| 91 | PNCK | 0.55980284 |
| 92 | BMX | 0.54900690 |
| 93 | RPS6KA1 | 0.52631151 |
| 94 | PRKAA1 | 0.51827184 |
| 95 | TRIM28 | 0.50619317 |
| 96 | DAPK1 | 0.49398280 |
| 97 | DAPK3 | 0.48802940 |
| 98 | PRPF4B | 0.47855256 |
| 99 | MAPK8 | 0.47601276 |
| 100 | ROCK2 | 0.46592637 |
| 101 | SGK3 | 0.46411127 |
| 102 | MAP2K2 | 0.46333629 |
| 103 | AURKA | 0.45894128 |
| 104 | BMPR1B | 0.45850992 |
| 105 | SGK1 | 0.45624530 |
| 106 | BRAF | 0.45555361 |
| 107 | EPHA4 | 0.45426218 |
| 108 | ADRBK1 | 0.44756485 |
| 109 | TIE1 | 0.43550068 |
| 110 | MAP2K1 | 0.43109569 |
| 111 | CSNK1A1L | 0.42694211 |
| 112 | MAP3K6 | 0.42403163 |
| 113 | ADRBK2 | 0.41400859 |
| 114 | CAMK1 | 0.41086502 |
| 115 | PRKCH | 0.40927374 |
| 116 | PRKD1 | 0.40652301 |
| 117 | RPS6KA3 | 0.40078927 |
| 118 | CAMK1G | 0.39076504 |
| 119 | GSK3B | 0.38261474 |
| 120 | PRKCE | 0.36871023 |
| 121 | AKT2 | 0.36165944 |
| 122 | MAPK12 | 0.36094279 |
| 123 | FYN | 0.35990977 |
| 124 | PTK2B | 0.35681231 |
| 125 | CAMK2D | 0.35200926 |
| 126 | MAPK10 | 0.35094749 |
| 127 | CAMK4 | 0.34796820 |
| 128 | HIPK2 | 0.33592812 |
| 129 | TNK2 | 0.33043270 |
| 130 | MAP3K11 | 0.32930731 |
| 131 | CDK1 | 0.32463344 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.96074765 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 2.67979659 |
| 3 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.44804494 |
| 4 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 2.19562500 |
| 5 | GABAergic synapse_Homo sapiens_hsa04727 | 2.03070854 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.99381108 |
| 7 | Axon guidance_Homo sapiens_hsa04360 | 1.98028112 |
| 8 | Circadian entrainment_Homo sapiens_hsa04713 | 1.97436600 |
| 9 | Olfactory transduction_Homo sapiens_hsa04740 | 1.93374148 |
| 10 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.85836442 |
| 11 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.78959458 |
| 12 | Gap junction_Homo sapiens_hsa04540 | 1.77082649 |
| 13 | Morphine addiction_Homo sapiens_hsa05032 | 1.76223772 |
| 14 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.68657006 |
| 15 | Long-term potentiation_Homo sapiens_hsa04720 | 1.63943940 |
| 16 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.63479778 |
| 17 | Insulin secretion_Homo sapiens_hsa04911 | 1.57992362 |
| 18 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.56473335 |
| 19 | Endometrial cancer_Homo sapiens_hsa05213 | 1.54832010 |
| 20 | Glioma_Homo sapiens_hsa05214 | 1.52584189 |
| 21 | Alcoholism_Homo sapiens_hsa05034 | 1.46670608 |
| 22 | Salivary secretion_Homo sapiens_hsa04970 | 1.46257051 |
| 23 | Colorectal cancer_Homo sapiens_hsa05210 | 1.42043557 |
| 24 | Taste transduction_Homo sapiens_hsa04742 | 1.39684256 |
| 25 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.34363098 |
| 26 | Cocaine addiction_Homo sapiens_hsa05030 | 1.31938184 |
| 27 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.31800595 |
| 28 | Long-term depression_Homo sapiens_hsa04730 | 1.29031459 |
| 29 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.27932647 |
| 30 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.27828446 |
| 31 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.26182442 |
| 32 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.25388745 |
| 33 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.24628540 |
| 34 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.24596537 |
| 35 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.24473126 |
| 36 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.19230862 |
| 37 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.18311624 |
| 38 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.15638058 |
| 39 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.15578140 |
| 40 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.14375339 |
| 41 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.12912922 |
| 42 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.12359821 |
| 43 | Melanogenesis_Homo sapiens_hsa04916 | 1.06984306 |
| 44 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.06705181 |
| 45 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.04234233 |
| 46 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.02593246 |
| 47 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.02273078 |
| 48 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.01094163 |
| 49 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.98180061 |
| 50 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.98114324 |
| 51 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.93085406 |
| 52 | Renin secretion_Homo sapiens_hsa04924 | 0.92588625 |
| 53 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.90392146 |
| 54 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.89596030 |
| 55 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.87699219 |
| 56 | Phototransduction_Homo sapiens_hsa04744 | 0.87371279 |
| 57 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.87162800 |
| 58 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.84751033 |
| 59 | Endocytosis_Homo sapiens_hsa04144 | 0.84430084 |
| 60 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.84366070 |
| 61 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.84209377 |
| 62 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.83885308 |
| 63 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.83883048 |
| 64 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.83074988 |
| 65 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.82655231 |
| 66 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.82534944 |
| 67 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.81378285 |
| 68 | Bladder cancer_Homo sapiens_hsa05219 | 0.80206509 |
| 69 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.79947422 |
| 70 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.79632529 |
| 71 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.79534114 |
| 72 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.79046642 |
| 73 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.78923448 |
| 74 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.78725436 |
| 75 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.78457779 |
| 76 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.76533374 |
| 77 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.76316866 |
| 78 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.76218537 |
| 79 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.76119300 |
| 80 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.76085735 |
| 81 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.75096875 |
| 82 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.72050454 |
| 83 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.68861195 |
| 84 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.68597074 |
| 85 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.67714544 |
| 86 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.67070566 |
| 87 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.67025884 |
| 88 | Melanoma_Homo sapiens_hsa05218 | 0.66325213 |
| 89 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.64965777 |
| 90 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.64933749 |
| 91 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.64689860 |
| 92 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.63630491 |
| 93 | Bile secretion_Homo sapiens_hsa04976 | 0.63432879 |
| 94 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.63429821 |
| 95 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.62955368 |
| 96 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.61617049 |
| 97 | Platelet activation_Homo sapiens_hsa04611 | 0.60890314 |
| 98 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.60873925 |
| 99 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.59593112 |
| 100 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.57634187 |
| 101 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.54265953 |
| 102 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.51219465 |
| 103 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.51148786 |
| 104 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.51106407 |
| 105 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.50610180 |
| 106 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.50211210 |
| 107 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.49163140 |
| 108 | Prion diseases_Homo sapiens_hsa05020 | 0.48147472 |
| 109 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.47670340 |
| 110 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.47178816 |
| 111 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.46543075 |
| 112 | Circadian rhythm_Homo sapiens_hsa04710 | 0.46028906 |
| 113 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.45222251 |
| 114 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.43243109 |
| 115 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.38849770 |
| 116 | Tight junction_Homo sapiens_hsa04530 | 0.36873767 |
| 117 | Focal adhesion_Homo sapiens_hsa04510 | 0.36569028 |
| 118 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.31347543 |
| 119 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.29490984 |
| 120 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.28787230 |
| 121 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.27415886 |

