SAMD15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.25381680
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.02267145
3cilium movement (GO:0003341)6.50437822
4epithelial cilium movement (GO:0003351)6.50386790
5cilium or flagellum-dependent cell motility (GO:0001539)5.98657551
6ribosomal small subunit biogenesis (GO:0042274)5.94128640
7proteasome assembly (GO:0043248)5.40671564
8DNA deamination (GO:0045006)5.38686688
9behavioral response to nicotine (GO:0035095)5.28298308
10motile cilium assembly (GO:0044458)5.25423008
11maturation of SSU-rRNA (GO:0030490)5.17036927
12axoneme assembly (GO:0035082)4.98004604
13rRNA modification (GO:0000154)4.90356720
14transcription elongation from RNA polymerase III promoter (GO:0006385)4.82751085
15termination of RNA polymerase III transcription (GO:0006386)4.82751085
16ribosome assembly (GO:0042255)4.80538474
17ribosomal large subunit biogenesis (GO:0042273)4.79182152
18regulation of nuclear cell cycle DNA replication (GO:0033262)4.72811136
19viral transcription (GO:0019083)4.62823529
20translational termination (GO:0006415)4.50368794
21ribonucleoprotein complex biogenesis (GO:0022613)4.48202379
22protein polyglutamylation (GO:0018095)4.48031376
23intraciliary transport (GO:0042073)4.36076628
24protein-cofactor linkage (GO:0018065)4.33957071
25deoxyribonucleoside diphosphate metabolic process (GO:0009186)4.30760956
26DNA damage response, detection of DNA damage (GO:0042769)4.30649554
27protein localization to cilium (GO:0061512)4.27841916
28deoxyribonucleotide biosynthetic process (GO:0009263)4.16114787
29nonmotile primary cilium assembly (GO:0035058)4.08278908
307-methylguanosine mRNA capping (GO:0006370)4.07828331
31spliceosomal snRNP assembly (GO:0000387)4.02734946
32cilium organization (GO:0044782)4.02028366
33RNA destabilization (GO:0050779)3.99342434
347-methylguanosine RNA capping (GO:0009452)3.99304307
35RNA capping (GO:0036260)3.99304307
36cilium assembly (GO:0042384)3.96419270
37ribosome biogenesis (GO:0042254)3.87742995
38rRNA processing (GO:0006364)3.85730811
39deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.85145556
40cellular anion homeostasis (GO:0030002)3.84800027
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.82577396
42transmission of nerve impulse (GO:0019226)3.81588572
43translational elongation (GO:0006414)3.80834166
44cotranslational protein targeting to membrane (GO:0006613)3.80210899
45translational initiation (GO:0006413)3.79206434
46transcription from RNA polymerase I promoter (GO:0006360)3.78319288
47protein targeting to ER (GO:0045047)3.75668656
48termination of RNA polymerase I transcription (GO:0006363)3.75128079
49ribosomal small subunit assembly (GO:0000028)3.74062119
50rRNA metabolic process (GO:0016072)3.73242940
51rRNA methylation (GO:0031167)3.68714623
52retinal ganglion cell axon guidance (GO:0031290)3.66733836
53spliceosomal complex assembly (GO:0000245)3.65956782
54translation (GO:0006412)3.65131302
55cellular protein complex disassembly (GO:0043624)3.64118139
56transcription elongation from RNA polymerase I promoter (GO:0006362)3.61121167
57regulation of mesoderm development (GO:2000380)3.61009568
58telomere maintenance via semi-conservative replication (GO:0032201)3.58999615
59fucose catabolic process (GO:0019317)3.58368794
60L-fucose metabolic process (GO:0042354)3.58368794
61L-fucose catabolic process (GO:0042355)3.58368794
62establishment of integrated proviral latency (GO:0075713)3.58230873
63transcription-coupled nucleotide-excision repair (GO:0006283)3.57125325
64cellular component biogenesis (GO:0044085)3.55906343
65regulation of cilium movement (GO:0003352)3.55346145
66DNA-dependent DNA replication (GO:0006261)3.55277081
67establishment of protein localization to endoplasmic reticulum (GO:0072599)3.55217234
68CENP-A containing nucleosome assembly (GO:0034080)3.54406708
69cilium morphogenesis (GO:0060271)3.53570228
70kinetochore assembly (GO:0051382)3.52967664
71protein localization to endoplasmic reticulum (GO:0070972)3.52771593
72RNA methylation (GO:0001510)3.52235201
73DNA replication checkpoint (GO:0000076)3.51539200
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50342228
75mitotic metaphase plate congression (GO:0007080)3.49378555
76maturation of 5.8S rRNA (GO:0000460)3.48812715
77viral life cycle (GO:0019058)3.47995381
78L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.43636739
79mitochondrial DNA replication (GO:0006264)3.43531208
80pseudouridine synthesis (GO:0001522)3.43516769
81cell proliferation in forebrain (GO:0021846)3.42822101
82positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.42125814
83chromatin remodeling at centromere (GO:0031055)3.41576176
84vitamin catabolic process (GO:0009111)3.41094281
85fat-soluble vitamin catabolic process (GO:0042363)3.41094281
86DNA strand elongation involved in DNA replication (GO:0006271)3.39145556
87regulation of mitochondrial translation (GO:0070129)3.38754197
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37747116
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37696457
90nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.37667416
91negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.34132415
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33477919
93specification of organ identity (GO:0010092)3.31029745
94regulation of centriole replication (GO:0046599)3.29133083
95retinal cone cell development (GO:0046549)3.25634465
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.25450872
97negative regulation of ligase activity (GO:0051352)3.25450872
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24730489
99detection of light stimulus involved in sensory perception (GO:0050962)3.24421768
100detection of light stimulus involved in visual perception (GO:0050908)3.24421768
101regulation of double-strand break repair via homologous recombination (GO:0010569)3.23530629
102amino acid salvage (GO:0043102)3.23422230
103L-methionine salvage (GO:0071267)3.23422230
104L-methionine biosynthetic process (GO:0071265)3.23422230
105DNA strand elongation (GO:0022616)3.19587255
106establishment of protein localization to mitochondrial membrane (GO:0090151)3.18467660
107tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18394699
108RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18394699
109telomere maintenance via recombination (GO:0000722)3.17707886
110DNA replication initiation (GO:0006270)3.16087954
111GTP biosynthetic process (GO:0006183)3.15506131
112microtubule bundle formation (GO:0001578)3.15228181
113heart field specification (GO:0003128)3.15079164
114secondary heart field specification (GO:0003139)3.15079164
115negative regulation of androgen receptor signaling pathway (GO:0060766)3.14194945
116regulation of cellular amino acid metabolic process (GO:0006521)3.13816404
117intra-S DNA damage checkpoint (GO:0031573)3.12546921
118transcription initiation from RNA polymerase I promoter (GO:0006361)3.12015954
119signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11841939
120signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11841939
121signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11841939
122protein complex disassembly (GO:0043241)3.09959574
123signal transduction involved in DNA damage checkpoint (GO:0072422)3.09881856
124signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09881856
125deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09833904
126kinetochore organization (GO:0051383)3.07838364
127nucleobase-containing small molecule interconversion (GO:0015949)3.07681524
128signal transduction involved in cell cycle checkpoint (GO:0072395)3.07461783
129left/right pattern formation (GO:0060972)3.06574418
130cellular component assembly involved in morphogenesis (GO:0010927)3.06528451
131telomere maintenance via telomere lengthening (GO:0010833)3.05178859
132single strand break repair (GO:0000012)3.05074833
133tRNA methylation (GO:0030488)3.05030520
134short-term memory (GO:0007614)3.04786773
135neuronal action potential (GO:0019228)3.04648261
136negative regulation of DNA-dependent DNA replication (GO:2000104)3.03653343
137negative regulation of transcription regulatory region DNA binding (GO:2000678)3.03479081
138sleep (GO:0030431)3.03356909
139positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99903103
140establishment of protein localization to mitochondrion (GO:0072655)2.99715620
141regulation of neurotransmitter uptake (GO:0051580)2.98456609
142centriole replication (GO:0007099)2.97954150
143sperm motility (GO:0030317)2.93338728
144pyrimidine nucleobase catabolic process (GO:0006208)2.92527282
145regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88253085
146adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.86939368
147phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.85413962
148G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74114426
149primary amino compound metabolic process (GO:1901160)2.73077436
150regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.72778933
151cell projection assembly (GO:0030031)2.72193683
152postsynaptic membrane organization (GO:0001941)2.69981581
153synaptic transmission, dopaminergic (GO:0001963)2.67385107
154parturition (GO:0007567)2.66635782
155left/right axis specification (GO:0070986)2.64914673
156behavioral response to cocaine (GO:0048148)2.62432304
157photoreceptor cell development (GO:0042461)2.60629744
158regulation of cardioblast proliferation (GO:0003264)2.59657983
159regulation of secondary heart field cardioblast proliferation (GO:0003266)2.59657983
160smoothened signaling pathway (GO:0007224)2.59394897
161multicellular organism reproduction (GO:0032504)2.57550662
162cornea development in camera-type eye (GO:0061303)2.56864403
163regulation of collateral sprouting (GO:0048670)2.54942722
164negative regulation of telomere maintenance (GO:0032205)2.54646077
165response to amphetamine (GO:0001975)2.52548183
166regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.52009402
167lateral sprouting from an epithelium (GO:0060601)2.51630759
168positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.50321982
169serotonin metabolic process (GO:0042428)2.50031997
170presynaptic membrane organization (GO:0097090)2.49475467
171retinal rod cell development (GO:0046548)2.48979779
172base-excision repair, AP site formation (GO:0006285)2.45275382
173microtubule-based movement (GO:0007018)2.42539988
174regulation of microtubule-based movement (GO:0060632)2.41622687
175limb development (GO:0060173)2.41423569
176appendage development (GO:0048736)2.41423569
177sensory perception of smell (GO:0007608)2.40790506
178eye photoreceptor cell development (GO:0042462)2.39940842
179somite rostral/caudal axis specification (GO:0032525)2.39386786
180photoreceptor cell maintenance (GO:0045494)2.37760919
181cell migration involved in gastrulation (GO:0042074)2.36402851
182positive regulation of gastrulation (GO:2000543)2.35207053
183positive regulation of cell fate commitment (GO:0010455)2.33934135
184platelet dense granule organization (GO:0060155)2.33600583
185startle response (GO:0001964)2.33563019
186protein localization to synapse (GO:0035418)2.32683231
187cellular response to ATP (GO:0071318)2.32239783
188determination of left/right symmetry (GO:0007368)2.31650141
189spinal cord motor neuron differentiation (GO:0021522)2.31205518
190synaptic transmission, cholinergic (GO:0007271)2.30721799
191nucleobase catabolic process (GO:0046113)2.30099282
192positive regulation of oligodendrocyte differentiation (GO:0048714)2.29513436
193substrate-independent telencephalic tangential migration (GO:0021826)2.28892585
194substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.28892585
195regulation of female receptivity (GO:0045924)2.28663596
196inner ear receptor stereocilium organization (GO:0060122)2.27043049
197negative regulation of axon guidance (GO:1902668)2.25921355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.89801142
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.67523066
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.33807209
4EZH2_22144423_ChIP-Seq_EOC_Human4.10796950
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.97534889
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.91635607
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.82821757
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.81808182
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.70582745
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.60536238
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.31565723
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.27184709
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25760573
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00671044
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97418477
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90981562
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90056237
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82291914
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.75862746
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74136295
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70379834
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.69128822
23GBX2_23144817_ChIP-Seq_PC3_Human2.68902998
24ZNF274_21170338_ChIP-Seq_K562_Hela2.64618347
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53807595
26VDR_23849224_ChIP-Seq_CD4+_Human2.44270512
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42938978
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41987474
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39929707
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35408202
31XRN2_22483619_ChIP-Seq_HELA_Human2.32453359
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26761645
33VDR_22108803_ChIP-Seq_LS180_Human2.24237756
34FUS_26573619_Chip-Seq_HEK293_Human2.22789051
35CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21786845
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.16169729
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.16169729
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.16169729
39TTF2_22483619_ChIP-Seq_HELA_Human2.13470848
40E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11606842
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09876166
42NANOG_18555785_ChIP-Seq_MESCs_Mouse2.09648822
43FOXM1_23109430_ChIP-Seq_U2OS_Human2.09449502
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08213947
45YY1_21170310_ChIP-Seq_MESCs_Mouse2.06053312
46NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03789978
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.98741794
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97682944
49FOXP3_21729870_ChIP-Seq_TREG_Human1.95221517
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94493872
51EWS_26573619_Chip-Seq_HEK293_Human1.94458148
52DCP1A_22483619_ChIP-Seq_HELA_Human1.92866474
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.91545137
54P300_19829295_ChIP-Seq_ESCs_Human1.91132570
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85711504
56ELK1_19687146_ChIP-ChIP_HELA_Human1.82782237
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82260514
58IGF1R_20145208_ChIP-Seq_DFB_Human1.78596909
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.78448079
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.75487864
61REST_21632747_ChIP-Seq_MESCs_Mouse1.71293268
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.70999859
63TAF15_26573619_Chip-Seq_HEK293_Human1.68708077
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.66975157
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65027625
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.64125514
67SMAD4_21799915_ChIP-Seq_A2780_Human1.63208424
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57826942
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57455525
70ER_23166858_ChIP-Seq_MCF-7_Human1.55757691
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.55174230
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54649684
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.53447155
74GABP_19822575_ChIP-Seq_HepG2_Human1.52026380
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51856485
76BCAT_22108803_ChIP-Seq_LS180_Human1.51336229
77RNF2_27304074_Chip-Seq_NSC_Mouse1.50409057
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49433322
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.49068682
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48527391
81STAT3_23295773_ChIP-Seq_U87_Human1.48526435
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48363564
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47297965
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46592334
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46403213
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44770523
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44710925
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.44340077
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.44029777
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.43656917
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43524031
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.43394416
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42382828
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40413511
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.39561551
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39140401
97CBP_20019798_ChIP-Seq_JUKART_Human1.37594690
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37594690
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.37514407
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37031777
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36103475
102SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35366112
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35360743
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35110407
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33482966
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33482966
107AHR_22903824_ChIP-Seq_MCF-7_Human1.33072547
108PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31658431
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31381710
110AR_25329375_ChIP-Seq_VCAP_Human1.30696364
111TCF4_23295773_ChIP-Seq_U87_Human1.30326232
112SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29887659
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28098377
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26970867
115MYC_18940864_ChIP-ChIP_HL60_Human1.25105667
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25036398
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24656415
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23145703
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21844627
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20309273
121PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19036202
122DROSHA_22980978_ChIP-Seq_HELA_Human1.18691979
123SALL1_21062744_ChIP-ChIP_HESCs_Human1.18090584
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17874086
125TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17796883
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17272952
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16924863
128TP63_19390658_ChIP-ChIP_HaCaT_Human1.16605781
129JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15062090
130ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15019442
131JUN_21703547_ChIP-Seq_K562_Human1.14207927
132TCF4_22108803_ChIP-Seq_LS180_Human1.14101382
133NCOR_22424771_ChIP-Seq_293T_Human1.13813812
134SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12725574
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11591224
136SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11014329
137TP53_22573176_ChIP-Seq_HFKS_Human1.10849018
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08422093
139RUNX2_22187159_ChIP-Seq_PCA_Human1.07943098
140AR_21909140_ChIP-Seq_LNCAP_Human1.07919779
141SMAD4_21741376_ChIP-Seq_EPCs_Human1.07702215
142RNF2_27304074_Chip-Seq_ESCs_Mouse1.06778141
143SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06742424
144KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06015298
145HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04667109
146GATA3_21878914_ChIP-Seq_MCF-7_Human1.03094932
147SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01934110
148SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01580480
149REST_18959480_ChIP-ChIP_MESCs_Mouse1.01523545
150GATA1_26923725_Chip-Seq_HPCs_Mouse1.00703498
151SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99873265
152TAL1_26923725_Chip-Seq_HPCs_Mouse0.99611711
153TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98870786
154NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98654937
155NANOG_19829295_ChIP-Seq_ESCs_Human0.98626747
156SOX2_19829295_ChIP-Seq_ESCs_Human0.98626747
157GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98366243
158TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98227658
159E2F1_21310950_ChIP-Seq_MCF-7_Human0.98130501
160CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97501592
161ERA_21632823_ChIP-Seq_H3396_Human0.96856673
162SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96811062
163SOX2_21211035_ChIP-Seq_LN229_Gbm0.95546711
164HOXB7_26014856_ChIP-Seq_BT474_Human0.95232437
165NANOG_16153702_ChIP-ChIP_HESCs_Human0.94959617
166SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94427118
167SOX17_20123909_ChIP-Seq_XEN_Mouse0.94411035
168POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94228422
169CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93142783
170CIITA_25753668_ChIP-Seq_RAJI_Human0.91553124
171CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91339512
172SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91173296
173KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90753359
174FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90324283
175CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86935136
176STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86705179
177ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86583932
178KDM5A_27292631_Chip-Seq_BREAST_Human0.86130484
179CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85326213
180SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85232983
181YY1_22570637_ChIP-Seq_MALME-3M_Human0.84441789
182SOX2_16153702_ChIP-ChIP_HESCs_Human0.83730732
183KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82589750
184OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82381709
185TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81358201
186NANOG_18692474_ChIP-Seq_MEFs_Mouse0.81277984
187IRF1_19129219_ChIP-ChIP_H3396_Human0.80824177
188CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79969135
189BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79214911
190DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77230922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.69457542
2MP0003693_abnormal_embryo_hatching4.32633238
3MP0001986_abnormal_taste_sensitivity4.09279000
4MP0009379_abnormal_foot_pigmentation4.05629604
5MP0003111_abnormal_nucleus_morphology3.65291691
6MP0005423_abnormal_somatic_nervous3.42975295
7MP0003136_yellow_coat_color3.39175588
8MP0003718_maternal_effect3.22470464
9MP0004957_abnormal_blastocyst_morpholog2.93742827
10MP0000566_synostosis2.93203399
11MP0008932_abnormal_embryonic_tissue2.90461195
12MP0002234_abnormal_pharynx_morphology2.90076682
13MP0008058_abnormal_DNA_repair2.89689481
14MP0008057_abnormal_DNA_replication2.88523420
15MP0003941_abnormal_skin_development2.87072978
16MP0003077_abnormal_cell_cycle2.63223691
17MP0002102_abnormal_ear_morphology2.60320705
18MP0010094_abnormal_chromosome_stability2.58342476
19MP0006292_abnormal_olfactory_placode2.56021325
20MP0004381_abnormal_hair_follicle2.32884258
21MP0002736_abnormal_nociception_after2.20201105
22MP0003786_premature_aging2.19397907
23MP0001188_hyperpigmentation2.12354730
24MP0003011_delayed_dark_adaptation2.11884527
25MP0008007_abnormal_cellular_replicative2.11808335
26MP0001984_abnormal_olfaction2.09026435
27MP0001968_abnormal_touch/_nociception2.06870990
28MP0004133_heterotaxia2.03542068
29MP0008875_abnormal_xenobiotic_pharmacok1.89644565
30MP0008877_abnormal_DNA_methylation1.85209803
31MP0005646_abnormal_pituitary_gland1.85209256
32MP0002909_abnormal_adrenal_gland1.83903579
33MP0002277_abnormal_respiratory_mucosa1.81232758
34MP0002160_abnormal_reproductive_system1.81206403
35MP0000778_abnormal_nervous_system1.81048767
36MP0003315_abnormal_perineum_morphology1.72522443
37MP0000631_abnormal_neuroendocrine_gland1.71521155
38MP0005389_reproductive_system_phenotype1.64462938
39MP0002837_dystrophic_cardiac_calcinosis1.59464194
40MP0005409_darkened_coat_color1.58570414
41MP0002928_abnormal_bile_duct1.52515376
42MP0002734_abnormal_mechanical_nocicepti1.48839061
43MP0009046_muscle_twitch1.48299834
44MP0002272_abnormal_nervous_system1.44551427
45MP0003787_abnormal_imprinting1.43491099
46MP0001919_abnormal_reproductive_system1.43267480
47MP0000762_abnormal_tongue_morphology1.42584628
48MP0005395_other_phenotype1.40845852
49MP0004885_abnormal_endolymph1.40083155
50MP0003938_abnormal_ear_development1.38359471
51MP0002210_abnormal_sex_determination1.37969240
52MP0002282_abnormal_trachea_morphology1.37645635
53MP0009745_abnormal_behavioral_response1.35231851
54MP0002735_abnormal_chemical_nociception1.35158677
55MP0004742_abnormal_vestibular_system1.32853632
56MP0004142_abnormal_muscle_tone1.29330755
57MP0002557_abnormal_social/conspecific_i1.27643601
58MP0004145_abnormal_muscle_electrophysio1.27504364
59MP0000383_abnormal_hair_follicle1.25606325
60MP0002132_abnormal_respiratory_system1.22099941
61MP0003283_abnormal_digestive_organ1.22024034
62MP0002572_abnormal_emotion/affect_behav1.19734759
63MP0000955_abnormal_spinal_cord1.19050290
64MP0001145_abnormal_male_reproductive1.18498042
65MP0001970_abnormal_pain_threshold1.17725088
66MP0001486_abnormal_startle_reflex1.15241513
67MP0002184_abnormal_innervation1.14026806
68MP0005195_abnormal_posterior_eye1.13575886
69MP0005410_abnormal_fertilization1.13237456
70MP0008872_abnormal_physiological_respon1.11147218
71MP0008995_early_reproductive_senescence1.10481303
72MP0003806_abnormal_nucleotide_metabolis1.10466185
73MP0000613_abnormal_salivary_gland1.10209746
74MP0003937_abnormal_limbs/digits/tail_de1.10203526
75MP0001324_abnormal_eye_pigmentation1.09329291
76MP0001529_abnormal_vocalization1.07618040
77MP0005084_abnormal_gallbladder_morpholo1.06754647
78MP0003950_abnormal_plasma_membrane1.06603209
79MP0001929_abnormal_gametogenesis1.05174461
80MP0003890_abnormal_embryonic-extraembry1.04852533
81MP0000653_abnormal_sex_gland1.03308523
82MP0000427_abnormal_hair_cycle1.01981159
83MP0000049_abnormal_middle_ear1.00150328
84MP0001727_abnormal_embryo_implantation0.99019305
85MP0001286_abnormal_eye_development0.98834312
86MP0003635_abnormal_synaptic_transmissio0.98551251
87MP0003121_genomic_imprinting0.98432792
88MP0001853_heart_inflammation0.98220139
89MP0010030_abnormal_orbit_morphology0.97251469
90MP0005360_urolithiasis0.97221481
91MP0001730_embryonic_growth_arrest0.96586832
92MP0002063_abnormal_learning/memory/cond0.96574997
93MP0003119_abnormal_digestive_system0.96173690
94MP0000350_abnormal_cell_proliferation0.95235861
95MP0002882_abnormal_neuron_morphology0.93053930
96MP0000534_abnormal_ureter_morphology0.93003656
97MP0006072_abnormal_retinal_apoptosis0.92767137
98MP0001873_stomach_inflammation0.92278849
99MP0008789_abnormal_olfactory_epithelium0.92186983
100MP0002751_abnormal_autonomic_nervous0.92021800
101MP0008260_abnormal_autophagy0.91926406
102MP0001502_abnormal_circadian_rhythm0.91745077
103MP0003942_abnormal_urinary_system0.91335751
104MP0002067_abnormal_sensory_capabilities0.91153606
105MP0004043_abnormal_pH_regulation0.90901857
106MP0001963_abnormal_hearing_physiology0.90740153
107MP0002233_abnormal_nose_morphology0.90452537
108MP0002733_abnormal_thermal_nociception0.90256571
109MP0003698_abnormal_male_reproductive0.89586583
110MP0002085_abnormal_embryonic_tissue0.88317978
111MP0009053_abnormal_anal_canal0.88197918
112MP0000313_abnormal_cell_death0.87757742
113MP0000678_abnormal_parathyroid_gland0.87433839
114MP0003755_abnormal_palate_morphology0.86921592
115MP0003122_maternal_imprinting0.86891377
116MP0005248_abnormal_Harderian_gland0.86713571
117MP0005171_absent_coat_pigmentation0.86501270
118MP0004859_abnormal_synaptic_plasticity0.85964608
119MP0000372_irregular_coat_pigmentation0.85419277
120MP0005386_behavior/neurological_phenoty0.85303975
121MP0004924_abnormal_behavior0.85303975
122MP0010386_abnormal_urinary_bladder0.84254284
123MP0005075_abnormal_melanosome_morpholog0.83436885
124MP0002752_abnormal_somatic_nervous0.83417972
125MP0001440_abnormal_grooming_behavior0.83172155
126MP0006035_abnormal_mitochondrial_morpho0.83069154
127MP0001293_anophthalmia0.82230795
128MP0005187_abnormal_penis_morphology0.82005734
129MP0003878_abnormal_ear_physiology0.81523595
130MP0005377_hearing/vestibular/ear_phenot0.81523595
131MP0003880_abnormal_central_pattern0.80819718
132MP0003123_paternal_imprinting0.79392554
133MP0002111_abnormal_tail_morphology0.78361696
134MP0003936_abnormal_reproductive_system0.78303875
135MP0001905_abnormal_dopamine_level0.77630529
136MP0005253_abnormal_eye_physiology0.77466523
137MP0001542_abnormal_bone_strength0.77246698
138MP0005379_endocrine/exocrine_gland_phen0.77229603
139MP0000647_abnormal_sebaceous_gland0.77204265
140MP0000026_abnormal_inner_ear0.75593614
141MP0005394_taste/olfaction_phenotype0.73365161
142MP0005499_abnormal_olfactory_system0.73365161
143MP0001485_abnormal_pinna_reflex0.70869579
144MP0000462_abnormal_digestive_system0.70515612
145MP0005451_abnormal_body_composition0.68507498
146MP0002938_white_spotting0.67165109
147MP0003186_abnormal_redox_activity0.67113635
148MP0005380_embryogenesis_phenotype0.66089700
149MP0001672_abnormal_embryogenesis/_devel0.66089700
150MP0001697_abnormal_embryo_size0.65362139
151MP0002080_prenatal_lethality0.64119402
152MP0000432_abnormal_head_morphology0.63253718
153MP0002638_abnormal_pupillary_reflex0.62943418
154MP0006276_abnormal_autonomic_nervous0.60794377
155MP0001119_abnormal_female_reproductive0.59329605
156MP0005391_vision/eye_phenotype0.57335886
157MP0001661_extended_life_span0.56531583
158MP0005551_abnormal_eye_electrophysiolog0.56201852
159MP0003861_abnormal_nervous_system0.55858089

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.15908191
2Absent/shortened dynein arms (HP:0200106)7.15908191
3Abnormal respiratory epithelium morphology (HP:0012253)6.62894061
4Abnormal respiratory motile cilium morphology (HP:0005938)6.62894061
5Abnormal ciliary motility (HP:0012262)6.50685011
6Progressive external ophthalmoplegia (HP:0000590)6.34225391
7Abnormal respiratory motile cilium physiology (HP:0012261)6.20970174
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.84248387
9Breast hypoplasia (HP:0003187)5.60653781
10Duplicated collecting system (HP:0000081)5.37216512
11Muscle abnormality related to mitochondrial dysfunction (HP:0003800)5.18810285
12Rhinitis (HP:0012384)4.91671396
13Abnormality of the renal collecting system (HP:0004742)4.61217139
14Molar tooth sign on MRI (HP:0002419)4.43513420
15Abnormality of midbrain morphology (HP:0002418)4.43513420
16Pancreatic fibrosis (HP:0100732)4.15341120
17Pancreatic cysts (HP:0001737)4.10453376
18True hermaphroditism (HP:0010459)4.09991062
19Reticulocytopenia (HP:0001896)4.08975472
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.90289700
21Birth length less than 3rd percentile (HP:0003561)3.89772288
22Nephronophthisis (HP:0000090)3.76859827
23Cerebral hypomyelination (HP:0006808)3.73485349
24Chronic hepatic failure (HP:0100626)3.62327816
25Macrocytic anemia (HP:0001972)3.61309778
26Medial flaring of the eyebrow (HP:0010747)3.42667567
27Chronic bronchitis (HP:0004469)3.37746248
28Bronchiectasis (HP:0002110)3.37643670
29External ophthalmoplegia (HP:0000544)3.19928665
30Rough bone trabeculation (HP:0100670)3.18463083
31Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16855355
32Carpal bone hypoplasia (HP:0001498)3.15748484
33Absent radius (HP:0003974)3.11302419
34Long foot (HP:0001833)3.09662292
35Gait imbalance (HP:0002141)3.08878686
36Abnormality of the renal medulla (HP:0100957)3.08306622
37Aplasia/Hypoplasia of the earlobes (HP:0009906)3.05780386
38Occipital encephalocele (HP:0002085)3.02030661
39Congenital primary aphakia (HP:0007707)2.99696156
40Aplasia involving forearm bones (HP:0009822)2.95339260
41Absent forearm bone (HP:0003953)2.95339260
42Congenital stationary night blindness (HP:0007642)2.94262369
43Acute lymphatic leukemia (HP:0006721)2.93943840
44Hypoplastic nipples (HP:0002557)2.92635062
45Cystic liver disease (HP:0006706)2.92371190
46Abnormality of cells of the erythroid lineage (HP:0012130)2.89344479
47Ureteral duplication (HP:0000073)2.85771592
48Chromsome breakage (HP:0040012)2.85507675
49Progressive muscle weakness (HP:0003323)2.78033936
50Tubular atrophy (HP:0000092)2.76912993
51Nephrogenic diabetes insipidus (HP:0009806)2.76011241
52Aplasia/Hypoplasia involving the musculature (HP:0001460)2.74464860
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.73938965
54Abnormal number of erythroid precursors (HP:0012131)2.72116307
55Pallor (HP:0000980)2.67311760
56Upper limb muscle weakness (HP:0003484)2.65925273
57Granulocytopenia (HP:0001913)2.65245029
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58429879
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58429879
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.56337055
61Acute necrotizing encephalopathy (HP:0006965)2.55078527
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.54202446
63Stomach cancer (HP:0012126)2.49596031
64Decreased central vision (HP:0007663)2.48131012
65Adactyly (HP:0009776)2.47673607
66Infertility (HP:0000789)2.47026902
67Secondary amenorrhea (HP:0000869)2.44600934
68Type II lissencephaly (HP:0007260)2.43869056
69Anencephaly (HP:0002323)2.42439975
70Genital tract atresia (HP:0001827)2.42325444
71Mitochondrial inheritance (HP:0001427)2.42178669
72Glucose intolerance (HP:0000833)2.42065247
73Abnormal trabecular bone morphology (HP:0100671)2.41166589
74Horseshoe kidney (HP:0000085)2.41122576
75Sclerocornea (HP:0000647)2.40986509
76Exercise intolerance (HP:0003546)2.40132300
77Vaginal atresia (HP:0000148)2.39902630
78Meckel diverticulum (HP:0002245)2.39659005
79Conical tooth (HP:0000698)2.39404767
80Triphalangeal thumb (HP:0001199)2.36565845
81Patellar aplasia (HP:0006443)2.34605775
82Increased serum lactate (HP:0002151)2.33472579
83Parakeratosis (HP:0001036)2.32799994
84Bony spicule pigmentary retinopathy (HP:0007737)2.31138825
85Aplasia/Hypoplasia of the patella (HP:0006498)2.30053023
86Anterior segment dysgenesis (HP:0007700)2.29233444
87Increased hepatocellular lipid droplets (HP:0006565)2.28825043
88Abnormal ventriculo-arterial connection (HP:0011563)2.28024198
89Transposition of the great arteries (HP:0001669)2.28024198
90Abnormal connection of the cardiac segments (HP:0011545)2.28024198
91Proximal tubulopathy (HP:0000114)2.27362881
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.27119701
93Abnormality of the preputium (HP:0100587)2.25842797
94Postaxial foot polydactyly (HP:0001830)2.24611819
95Sparse eyelashes (HP:0000653)2.24081635
96Recurrent sinusitis (HP:0011108)2.23662170
97Oral leukoplakia (HP:0002745)2.22298779
98Lip pit (HP:0100267)2.21186583
99Aplasia/Hypoplasia of the breasts (HP:0010311)2.20930657
1003-Methylglutaconic aciduria (HP:0003535)2.20268451
101Abnormality of the ileum (HP:0001549)2.19946580
102Abnormality of the renal cortex (HP:0011035)2.18991321
103Absent thumb (HP:0009777)2.18857055
104Postaxial hand polydactyly (HP:0001162)2.18584790
105Poor coordination (HP:0002370)2.16607962
106Abnormality of the labia minora (HP:0012880)2.15671717
107Renal Fanconi syndrome (HP:0001994)2.15589230
108Supernumerary spleens (HP:0009799)2.15272815
109Aplasia/hypoplasia of the uterus (HP:0008684)2.14185863
110Breast aplasia (HP:0100783)2.13068207
111Autoimmune thrombocytopenia (HP:0001973)2.11930539
112Cleft eyelid (HP:0000625)2.10122413
113Concave nail (HP:0001598)2.09521111
114Hepatocellular necrosis (HP:0001404)2.09122807
115Tubulointerstitial nephritis (HP:0001970)2.07483603
116Male pseudohermaphroditism (HP:0000037)2.07298575
117Epileptic encephalopathy (HP:0200134)2.06546617
118Trismus (HP:0000211)2.06304876
119Testicular atrophy (HP:0000029)2.05219078
120Absent hand (HP:0004050)2.05188442
121Pulmonary artery stenosis (HP:0004415)2.03027244
122Increased CSF lactate (HP:0002490)2.01084596
123Abnormal mitochondria in muscle tissue (HP:0008316)2.00170474
124Premature graying of hair (HP:0002216)1.99597193
125Chronic sinusitis (HP:0011109)1.99242790
126Congenital hepatic fibrosis (HP:0002612)1.99223952
127Premature ovarian failure (HP:0008209)1.97968299
128Narrow forehead (HP:0000341)1.97600344
129Clubbing of toes (HP:0100760)1.96680910
130Abnormality of the axillary hair (HP:0100134)1.96203969
131Abnormality of secondary sexual hair (HP:0009888)1.96203969
132Microvesicular hepatic steatosis (HP:0001414)1.96190095
133Oligodactyly (hands) (HP:0001180)1.92941418
134Congenital ichthyosiform erythroderma (HP:0007431)1.92757855
135Preaxial hand polydactyly (HP:0001177)1.92391834
136Impulsivity (HP:0100710)1.89515831
137CNS hypomyelination (HP:0003429)1.89470008
138Fetal akinesia sequence (HP:0001989)1.88721237
139Attenuation of retinal blood vessels (HP:0007843)1.87747688
140Progressive macrocephaly (HP:0004481)1.87648288
141Amniotic constriction ring (HP:0009775)1.87504271
142Abnormality of placental membranes (HP:0011409)1.87504271
143Supernumerary bones of the axial skeleton (HP:0009144)1.86771821
144Depressed nasal tip (HP:0000437)1.85995688
145Aplasia/Hypoplasia of the uvula (HP:0010293)1.85240362
146Type 2 muscle fiber atrophy (HP:0003554)1.84921738
147Synostosis involving the elbow (HP:0003938)1.84643255
148Humeroradial synostosis (HP:0003041)1.84643255
149Acute encephalopathy (HP:0006846)1.83361170
150Aplasia of the musculature (HP:0100854)1.83046196
151Furrowed tongue (HP:0000221)1.82954457
152Abolished electroretinogram (ERG) (HP:0000550)1.82184418
153Constricted visual fields (HP:0001133)1.80524156
154Nasal polyposis (HP:0100582)1.80510963
155Congenital, generalized hypertrichosis (HP:0004540)1.80358166
156Aplasia/Hypoplasia of the tibia (HP:0005772)1.80117283
157Abdominal situs inversus (HP:0003363)1.79231437
158Overfolded helix (HP:0000396)1.78971668
159Exertional dyspnea (HP:0002875)1.78349523
160Abnormality of abdominal situs (HP:0011620)1.78344266
161Stenosis of the external auditory canal (HP:0000402)1.76145516
162Polydipsia (HP:0001959)1.75213278
163Abnormal drinking behavior (HP:0030082)1.75213278
164Chorioretinal coloboma (HP:0000567)1.73795891
165Progressive cerebellar ataxia (HP:0002073)1.73389640
166Aganglionic megacolon (HP:0002251)1.71964804
167Broad foot (HP:0001769)1.71356479
168Renal dysplasia (HP:0000110)1.70493989
169Aplasia/Hypoplasia of the lens (HP:0008063)1.70293511
170Aplasia/Hypoplasia of the spleen (HP:0010451)1.69850120
171Abnormality of macular pigmentation (HP:0008002)1.68287116
172Retinal dysplasia (HP:0007973)1.67884572
173Failure to thrive in infancy (HP:0001531)1.67398518
174Short tibia (HP:0005736)1.65546353
175Abnormality of cochlea (HP:0000375)1.63390548
176Asplenia (HP:0001746)1.63258925
177Cerebellar dysplasia (HP:0007033)1.61153834
178Specific learning disability (HP:0001328)1.60719129
179Enlarged epiphyses (HP:0010580)1.58928425
180Anophthalmia (HP:0000528)1.58714191
181Chin dimple (HP:0010751)1.58070373
182Oculomotor apraxia (HP:0000657)1.56570459
183Highly arched eyebrow (HP:0002553)1.56074005
184Oligodactyly (HP:0012165)1.55361669
185Optic nerve hypoplasia (HP:0000609)1.54745846
186Tubulointerstitial abnormality (HP:0001969)1.53517930
187Prominent nasal bridge (HP:0000426)1.52822354
188Abnormal rod and cone electroretinograms (HP:0008323)1.52080823
189Astigmatism (HP:0000483)1.50299020
190Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.50069627
191Multicystic kidney dysplasia (HP:0000003)1.49981245
192Myokymia (HP:0002411)1.49938002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK36.05786143
2BUB14.66537152
3PLK44.54648515
4STK164.28641698
5PIK3CA3.80016623
6MARK13.67518025
7ZAK3.62435002
8MAPK153.32594229
9IRAK22.98942837
10IRAK42.85996801
11NUAK12.74670866
12EIF2AK12.70991645
13WNK32.70843245
14CAMKK22.66245205
15IRAK12.51029057
16TLK12.46223206
17WEE12.43029021
18SRPK12.29297075
19TESK22.19578407
20TTK2.10977813
21FRK2.04818209
22EPHA22.03133679
23PINK12.01980407
24OXSR11.98443738
25PNCK1.88033566
26PBK1.79799865
27CAMK1D1.77932891
28VRK11.69363025
29WNK41.61022298
30MAPK131.59739976
31CAMK1G1.57966496
32MAP3K41.56235608
33INSRR1.48184994
34EPHA41.47092493
35MAP4K21.46361140
36MUSK1.46255939
37DYRK31.40243750
38TSSK61.38041037
39PRKCG1.37996395
40PAK31.28889571
41PLK31.22980174
42EIF2AK31.20586709
43PLK11.18299264
44CDC42BPA1.15145428
45MINK11.13372086
46NME11.11375675
47NME21.10556771
48AKT31.10421700
49MKNK21.09512012
50NTRK21.07546017
51TRIM281.07122187
52DYRK21.05842419
53MKNK10.96658258
54MAP2K70.95295771
55CHEK20.95055955
56CSNK1G20.94617763
57AURKA0.92168327
58CDC70.88844208
59PRKCI0.88587090
60CAMKK10.88576470
61RPS6KB20.88112559
62STK38L0.85143420
63EIF2AK20.84051756
64MAP3K90.83277128
65CASK0.81453076
66PAK40.80314050
67ATR0.79066479
68CSNK1G30.76310936
69MAP2K40.74386724
70NEK60.74309274
71ABL20.72922827
72LIMK10.71056534
73LATS20.70531202
74BRAF0.69913353
75AURKB0.69142794
76CSNK1G10.68929700
77CSNK1A1L0.65731774
78CDK90.65554149
79CAMK10.65130962
80RPS6KA50.62157277
81MAP2K60.62001421
82ADRBK10.61871165
83MARK30.60562426
84KDR0.60373382
85CDK70.60143844
86MAP2K20.59966000
87CAMK2B0.59752620
88TESK10.58353653
89GRK50.57588363
90PTK20.57000847
91CHEK10.55904038
92PRKCE0.54791736
93CAMK2G0.53994803
94PRKACA0.53773527
95PRKCZ0.53688738
96STK40.52313755
97TNIK0.51304554
98CCNB10.50753314
99ROCK20.50379622
100BLK0.49019157
101MST40.48964481
102CSNK2A10.47594969
103PAK10.47299735
104CAMK2D0.46515274
105PRKD30.46180841
106CSNK2A20.46123781
107PIM20.46108468
108BRD40.45886143
109NTRK30.44837453
110CLK10.44256370
111MAP3K80.43409566
112EPHB20.42757602
113ATM0.42730293
114STK30.42161103
115PRKG10.41868610
116ERBB30.40812514
117SGK2230.38546655
118SGK4940.38546655
119PRKCH0.38436530
120PTK2B0.38436089
121CSNK1E0.37727203
122CSNK1D0.37646687
123WNK10.37527424
124MAP3K110.37498549
125MAPKAPK30.37134915
126BMPR20.37125325
127GRK10.36860941
128VRK20.36819793
129TAF10.36710948
130SIK20.36492103
131NEK20.35818046
132BCR0.35113900
133STK110.34754674
134TGFBR10.34203869
135PRKCA0.33531210
136CDK50.33508628
137PKN10.33411969
138ACVR1B0.31726299
139PLK20.30669866
140BRSK20.30068280
141CDK10.29272554
142CDK20.28081020
143ARAF0.26909139
144ADRBK20.26855225
145STK390.25055314
146BMPR1B0.23872837
147CDK190.22498757
148IKBKB0.22399031
149MAPK40.22317620
150NEK10.21079149
151MAPK70.19413399
152ROCK10.18411381
153PRKDC0.17551614
154DAPK30.16917463
155FES0.16506001
156YES10.15722396
157BRSK10.15107688
158CDK30.14481511
159ALK0.13951893
160NLK0.13376655
161GRK70.12980937
162CAMK2A0.12345282

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.05492078
2RNA polymerase_Homo sapiens_hsa030204.62056022
3Proteasome_Homo sapiens_hsa030504.24151673
4DNA replication_Homo sapiens_hsa030303.52695301
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35062528
6Mismatch repair_Homo sapiens_hsa034303.19814360
7Spliceosome_Homo sapiens_hsa030403.03190663
8Fanconi anemia pathway_Homo sapiens_hsa034603.01951998
9Pyrimidine metabolism_Homo sapiens_hsa002403.01359166
10Oxidative phosphorylation_Homo sapiens_hsa001902.63798272
11Homologous recombination_Homo sapiens_hsa034402.52638001
12Caffeine metabolism_Homo sapiens_hsa002322.45657902
13Nucleotide excision repair_Homo sapiens_hsa034202.41498052
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35224723
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27476828
16RNA transport_Homo sapiens_hsa030132.26716325
17Chemical carcinogenesis_Homo sapiens_hsa052042.15965123
18Basal transcription factors_Homo sapiens_hsa030222.14494951
19Parkinsons disease_Homo sapiens_hsa050122.07679759
20One carbon pool by folate_Homo sapiens_hsa006702.05848048
21Huntingtons disease_Homo sapiens_hsa050162.04726178
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02636239
23Base excision repair_Homo sapiens_hsa034101.90000906
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82473135
25Olfactory transduction_Homo sapiens_hsa047401.78598259
26Purine metabolism_Homo sapiens_hsa002301.78200388
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73167154
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71909570
29Phototransduction_Homo sapiens_hsa047441.67877452
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66514884
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62575841
32Cell cycle_Homo sapiens_hsa041101.60562772
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.59544305
34RNA degradation_Homo sapiens_hsa030181.51111647
35Nitrogen metabolism_Homo sapiens_hsa009101.50656353
36Alzheimers disease_Homo sapiens_hsa050101.45025190
37Taste transduction_Homo sapiens_hsa047421.43366434
38Non-homologous end-joining_Homo sapiens_hsa034501.43161561
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40380518
40Protein export_Homo sapiens_hsa030601.37810670
41p53 signaling pathway_Homo sapiens_hsa041151.32228860
42Butanoate metabolism_Homo sapiens_hsa006501.26194619
43Histidine metabolism_Homo sapiens_hsa003401.26160726
44Epstein-Barr virus infection_Homo sapiens_hsa051691.23510474
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21112595
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.15829426
47Vitamin B6 metabolism_Homo sapiens_hsa007501.13471816
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08638635
49Morphine addiction_Homo sapiens_hsa050321.06927412
50Glutathione metabolism_Homo sapiens_hsa004801.05330761
51Sulfur metabolism_Homo sapiens_hsa009201.02251783
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99228035
53Selenocompound metabolism_Homo sapiens_hsa004500.98448520
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.95845548
55mRNA surveillance pathway_Homo sapiens_hsa030150.94476601
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93682541
57Folate biosynthesis_Homo sapiens_hsa007900.92956718
58Tryptophan metabolism_Homo sapiens_hsa003800.91366442
59Peroxisome_Homo sapiens_hsa041460.89516816
60Circadian entrainment_Homo sapiens_hsa047130.89404967
61GABAergic synapse_Homo sapiens_hsa047270.89251915
62Glutamatergic synapse_Homo sapiens_hsa047240.87121692
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.86289462
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83822591
65Insulin secretion_Homo sapiens_hsa049110.82003050
66Sphingolipid metabolism_Homo sapiens_hsa006000.80612928
67Propanoate metabolism_Homo sapiens_hsa006400.80182894
68Arachidonic acid metabolism_Homo sapiens_hsa005900.78788839
69Serotonergic synapse_Homo sapiens_hsa047260.78609757
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78198545
71Linoleic acid metabolism_Homo sapiens_hsa005910.78087819
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76615040
73Dopaminergic synapse_Homo sapiens_hsa047280.76311108
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75602961
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.74154579
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73582744
77Cocaine addiction_Homo sapiens_hsa050300.72800769
78Systemic lupus erythematosus_Homo sapiens_hsa053220.70965596
79African trypanosomiasis_Homo sapiens_hsa051430.68691111
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68362879
81Cardiac muscle contraction_Homo sapiens_hsa042600.67684961
82cAMP signaling pathway_Homo sapiens_hsa040240.66672636
83Metabolic pathways_Homo sapiens_hsa011000.64723927
84Ether lipid metabolism_Homo sapiens_hsa005650.64675671
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63983995
86Oocyte meiosis_Homo sapiens_hsa041140.60003874
87Arginine and proline metabolism_Homo sapiens_hsa003300.59638270
88Cholinergic synapse_Homo sapiens_hsa047250.58421117
89ABC transporters_Homo sapiens_hsa020100.57950446
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57045796
91Calcium signaling pathway_Homo sapiens_hsa040200.54225760
92Sulfur relay system_Homo sapiens_hsa041220.52939964
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51506879
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49480722
95Glycerolipid metabolism_Homo sapiens_hsa005610.48098468
96Collecting duct acid secretion_Homo sapiens_hsa049660.47431214
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42813839
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42641907
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.41927107
100Pentose phosphate pathway_Homo sapiens_hsa000300.41166379
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40915180
102Other glycan degradation_Homo sapiens_hsa005110.38676515
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36313785
104Regulation of autophagy_Homo sapiens_hsa041400.35738871
105Salivary secretion_Homo sapiens_hsa049700.33300414
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32368767
107Starch and sucrose metabolism_Homo sapiens_hsa005000.32069215
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31298513
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30628634
110Type II diabetes mellitus_Homo sapiens_hsa049300.28385593
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23402980
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23064523
113Retinol metabolism_Homo sapiens_hsa008300.22984358
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22432507
115Autoimmune thyroid disease_Homo sapiens_hsa053200.22428877
116Viral carcinogenesis_Homo sapiens_hsa052030.22407300
117Hedgehog signaling pathway_Homo sapiens_hsa043400.19768362
118Biosynthesis of amino acids_Homo sapiens_hsa012300.19284745
119Tyrosine metabolism_Homo sapiens_hsa003500.19182356
120Fatty acid elongation_Homo sapiens_hsa000620.18485167
121Alcoholism_Homo sapiens_hsa050340.18352000
122Phenylalanine metabolism_Homo sapiens_hsa003600.18219199
123Basal cell carcinoma_Homo sapiens_hsa052170.17498861
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.16554774
125Nicotine addiction_Homo sapiens_hsa050330.16348759
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.15343352
127Renin-angiotensin system_Homo sapiens_hsa046140.14916210
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14239787
129Herpes simplex infection_Homo sapiens_hsa051680.13192123
130Graft-versus-host disease_Homo sapiens_hsa053320.12958307
131HTLV-I infection_Homo sapiens_hsa051660.11969458
132Vibrio cholerae infection_Homo sapiens_hsa051100.11658872
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11597365
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08846324
135Wnt signaling pathway_Homo sapiens_hsa043100.08135929
136Primary immunodeficiency_Homo sapiens_hsa053400.07662248
137Tight junction_Homo sapiens_hsa045300.07566818
138Steroid biosynthesis_Homo sapiens_hsa001000.07359607
139Melanoma_Homo sapiens_hsa052180.07093211
140Rheumatoid arthritis_Homo sapiens_hsa053230.06019822
141beta-Alanine metabolism_Homo sapiens_hsa004100.03883212
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.03722529
143TGF-beta signaling pathway_Homo sapiens_hsa043500.03628314
144Axon guidance_Homo sapiens_hsa043600.03503114
145Vitamin digestion and absorption_Homo sapiens_hsa049770.03014730
146Hippo signaling pathway_Homo sapiens_hsa043900.02862149
147Fructose and mannose metabolism_Homo sapiens_hsa000510.02496607

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