SAMD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G8.92446212
2leukocyte aggregation (GO:0070486)8.70038783
3cellular response to interleukin-15 (GO:0071350)8.27572850
4regulation of isotype switching to IgG isotypes (GO:0048302)7.69474086
5positive thymic T cell selection (GO:0045059)7.63766741
6negative thymic T cell selection (GO:0045060)7.44333349
7negative T cell selection (GO:0043383)7.38379682
8response to interleukin-15 (GO:0070672)7.25432918
9interferon-gamma production (GO:0032609)6.99368530
10T cell migration (GO:0072678)6.94141050
11sequestering of actin monomers (GO:0042989)6.85636947
12thymic T cell selection (GO:0045061)6.70866064
13regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)6.64738614
14positive regulation of gamma-delta T cell activation (GO:0046645)6.60653685
15positive T cell selection (GO:0043368)6.48899206
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.43903028
17negative regulation of cell killing (GO:0031342)6.43903028
18positive regulation of lamellipodium assembly (GO:0010592)6.28186262
19regulation of B cell receptor signaling pathway (GO:0050855)6.17731976
20negative regulation of B cell mediated immunity (GO:0002713)6.15937622
21negative regulation of immunoglobulin mediated immune response (GO:0002890)6.15937622
22regulation of natural killer cell mediated immunity (GO:0002715)5.70303989
23regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.70303989
24T cell costimulation (GO:0031295)5.59843236
25lymphocyte costimulation (GO:0031294)5.56737690
26T cell selection (GO:0045058)5.46384056
27T cell receptor signaling pathway (GO:0050852)5.31745522
28regulation of gamma-delta T cell differentiation (GO:0045586)5.28391503
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.27734566
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.27734566
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.04140825
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.89204682
33positive regulation of lamellipodium organization (GO:1902745)4.83973646
34positive regulation of isotype switching (GO:0045830)4.79999840
35regulation of respiratory burst (GO:0060263)4.78098855
36positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.77321450
37positive regulation of natural killer cell mediated immunity (GO:0002717)4.77321450
38antigen receptor-mediated signaling pathway (GO:0050851)4.75769270
39activated T cell proliferation (GO:0050798)4.72707521
40regulation of T cell tolerance induction (GO:0002664)4.67401670
41regulation of B cell differentiation (GO:0045577)4.66695851
42regulation of immunoglobulin mediated immune response (GO:0002889)4.66491018
43leukocyte cell-cell adhesion (GO:0007159)4.65865269
44regulation of gamma-delta T cell activation (GO:0046643)4.63206037
45regulation of isotype switching (GO:0045191)4.59257917
46natural killer cell activation (GO:0030101)4.53461713
47regulation of leukocyte mediated cytotoxicity (GO:0001910)4.49193929
48regulation of B cell mediated immunity (GO:0002712)4.49130368
49negative regulation of lymphocyte mediated immunity (GO:0002707)4.45480649
50cytidine deamination (GO:0009972)4.40654993
51cytidine metabolic process (GO:0046087)4.40654993
52cytidine catabolic process (GO:0006216)4.40654993
53negative regulation of type 2 immune response (GO:0002829)4.34390381
54antigen processing and presentation of endogenous antigen (GO:0019883)4.34065260
55regulation of T cell receptor signaling pathway (GO:0050856)4.26635770
56lymphocyte migration (GO:0072676)4.25376035
57positive regulation of alpha-beta T cell proliferation (GO:0046641)4.24899247
58positive regulation of astrocyte differentiation (GO:0048711)4.22088931
59negative regulation of T cell receptor signaling pathway (GO:0050860)4.20792323
60DNA deamination (GO:0045006)4.20293232
61cellular defense response (GO:0006968)4.19246115
62Arp2/3 complex-mediated actin nucleation (GO:0034314)4.18608599
63positive regulation of DNA recombination (GO:0045911)4.17689301
64regulation of immunoglobulin production (GO:0002637)4.13926418
65positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.11890638
66pyrimidine ribonucleoside catabolic process (GO:0046133)4.10764232
67positive regulation of immunoglobulin mediated immune response (GO:0002891)4.08414785
68positive regulation of B cell mediated immunity (GO:0002714)4.08414785
69regulation of interferon-gamma-mediated signaling pathway (GO:0060334)4.07655783
70positive regulation of macrophage differentiation (GO:0045651)4.06954998
71regulation of response to interferon-gamma (GO:0060330)4.00522647
72regulation of cell killing (GO:0031341)3.99648945
73regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.97767013
74regulation of hydrogen peroxide metabolic process (GO:0010310)3.95364843
75negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.95144278
76regulation of alpha-beta T cell proliferation (GO:0046640)3.85955978
77antigen processing and presentation via MHC class Ib (GO:0002475)3.85766676
78negative regulation of execution phase of apoptosis (GO:1900118)3.82074645
79regulation of activation of Janus kinase activity (GO:0010533)3.80672686
80Peyers patch development (GO:0048541)3.79001454
81mucosal-associated lymphoid tissue development (GO:0048537)3.79001454
82adaptation of signaling pathway (GO:0023058)3.77808403
83positive regulation of T cell mediated cytotoxicity (GO:0001916)3.75558754
84positive regulation of tolerance induction (GO:0002645)3.74010755
85regulation of lymphocyte mediated immunity (GO:0002706)3.71821811
86positive regulation of cell killing (GO:0031343)3.70265612
87regulation of regulatory T cell differentiation (GO:0045589)3.61323416
88B cell receptor signaling pathway (GO:0050853)3.55433887
89positive regulation of calcium-mediated signaling (GO:0050850)3.54191186
90regulation of immunoglobulin secretion (GO:0051023)3.51220332
91negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.49170064
92regulation of type I interferon-mediated signaling pathway (GO:0060338)3.48655545
93mast cell activation (GO:0045576)3.42975493
94immune response-activating cell surface receptor signaling pathway (GO:0002429)3.42637140
95regulation of lamellipodium assembly (GO:0010591)3.37524625
96negative regulation of T cell mediated immunity (GO:0002710)3.36397253
97positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.36320083
98cellular response to zinc ion (GO:0071294)3.33320352
99T cell differentiation (GO:0030217)3.32614950
100positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.29843013
101negative regulation of leukocyte mediated immunity (GO:0002704)3.25733343
102positive regulation of lymphocyte mediated immunity (GO:0002708)3.24195550
103T cell activation (GO:0042110)3.21533456
104regulation of defense response to virus by virus (GO:0050690)3.19502258
105regulation of tolerance induction (GO:0002643)3.17385080
106natural killer cell differentiation (GO:0001779)3.15764908
107positive regulation of immunoglobulin production (GO:0002639)3.10052515
108cellular response to type I interferon (GO:0071357)3.09781787
109type I interferon signaling pathway (GO:0060337)3.09781787
110positive regulation of granulocyte differentiation (GO:0030854)3.09594111
111positive regulation of T cell activation (GO:0050870)3.09409176
112actin nucleation (GO:0045010)3.07934629
113response to xenobiotic stimulus (GO:0009410)3.07866278
114negative regulation of necroptotic process (GO:0060546)3.07153969
115negative regulation of humoral immune response (GO:0002921)3.06953028
116negative regulation of stress fiber assembly (GO:0051497)3.06531460
117regulation of T cell mediated cytotoxicity (GO:0001914)3.06290564
118response to type I interferon (GO:0034340)3.06278591
119negative regulation of phagocytosis (GO:0050765)3.02126629
120dendritic cell migration (GO:0036336)2.98593631
121respiratory burst (GO:0045730)2.97994746
122cytolysis (GO:0019835)2.97336162
123negative regulation of T cell apoptotic process (GO:0070233)2.96225707
124negative regulation of mast cell activation (GO:0033004)2.95065784
125positive regulation of natural killer cell differentiation (GO:0032825)2.94879631
126mast cell activation involved in immune response (GO:0002279)2.92391685
127mast cell degranulation (GO:0043303)2.92391685
128response to interferon-beta (GO:0035456)2.89724227
129dendritic cell chemotaxis (GO:0002407)2.86016214
130positive regulation of B cell differentiation (GO:0045579)2.82868966
131negative regulation of viral genome replication (GO:0045071)2.80326913
132hepatocyte apoptotic process (GO:0097284)2.75960497
133T cell mediated immunity (GO:0002456)2.75128086
134alpha-beta T cell activation (GO:0046631)2.74128017
135negative regulation of innate immune response (GO:0045824)2.73911118
136alpha-beta T cell differentiation (GO:0046632)2.73275581
137negative regulation of cAMP-mediated signaling (GO:0043951)2.66615506
138neutrophil activation (GO:0042119)2.65950343
139tolerance induction (GO:0002507)2.64805985
140positive regulation of interleukin-4 production (GO:0032753)2.64159580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.51583710
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.43175621
3STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.56177362
4STAT4_19710469_ChIP-ChIP_TH1__Mouse4.28888275
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.11016423
6ELF1_17652178_ChIP-ChIP_JURKAT_Human4.03367925
7RUNX_20019798_ChIP-Seq_JUKART_Human3.83645321
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.66787850
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.52298876
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.34323932
11MAF_26560356_Chip-Seq_TH1_Human3.30924930
12* MYB_26560356_Chip-Seq_TH2_Human3.26304635
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.22747223
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.17927555
15UTX_26944678_Chip-Seq_JUKART_Human3.16280670
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.00287826
17MYB_26560356_Chip-Seq_TH1_Human2.97390199
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92792435
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.60043135
20MYC_22102868_ChIP-Seq_BL_Human2.57859810
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46689732
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26394782
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.23196472
24GATA3_27048872_Chip-Seq_THYMUS_Human2.20690243
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.11731946
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.09201746
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04895732
28MAF_26560356_Chip-Seq_TH2_Human2.02317449
29* SMAD_19615063_ChIP-ChIP_OVARY_Human2.01001454
30SPI1_23547873_ChIP-Seq_NB4_Human2.00949535
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91011765
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.89429712
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88828017
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.83981902
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83446112
36VDR_22108803_ChIP-Seq_LS180_Human1.79387176
37VDR_21846776_ChIP-Seq_THP-1_Human1.76161483
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69783113
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.65282487
40GATA1_22025678_ChIP-Seq_K562_Human1.62064904
41VDR_24763502_ChIP-Seq_THP-1_Human1.61339014
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60158889
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59920205
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55090187
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50923711
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48469005
47SPI1_23127762_ChIP-Seq_K562_Human1.47004500
48IGF1R_20145208_ChIP-Seq_DFB_Human1.45576572
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45072559
50* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.44726289
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.44031561
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.43620229
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42459688
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41949982
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41291201
56GATA3_26560356_Chip-Seq_TH2_Human1.40838895
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40243011
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39754055
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38508509
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37499840
61ZNF274_21170338_ChIP-Seq_K562_Hela1.36889250
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36033162
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34118459
64EGR1_19032775_ChIP-ChIP_M12_Human1.33894819
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32543909
66TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.30310281
67CIITA_25753668_ChIP-Seq_RAJI_Human1.29460661
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29163089
69ER_23166858_ChIP-Seq_MCF-7_Human1.28542689
70BCAT_22108803_ChIP-Seq_LS180_Human1.28383293
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28126959
72KDM2B_26808549_Chip-Seq_DND41_Human1.28111810
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.24142095
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21166675
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19916562
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.19811301
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19563061
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.19450674
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18549667
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.17779284
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17687455
82TCF7_22412390_ChIP-Seq_EML_Mouse1.17531703
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13871742
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13646962
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13578015
86FLI1_21867929_ChIP-Seq_CD8_Mouse1.12865839
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10055269
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06985323
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06349676
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06125157
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06038018
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05001195
93TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.04790394
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04643442
95VDR_23849224_ChIP-Seq_CD4+_Human1.03452618
96TP53_22573176_ChIP-Seq_HFKS_Human1.02398740
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02093482
98GBX2_23144817_ChIP-Seq_PC3_Human1.00776778
99GATA3_26560356_Chip-Seq_TH1_Human1.00585456
100LXR_22292898_ChIP-Seq_THP-1_Human0.98963126
101NANOG_20526341_ChIP-Seq_ESCs_Human0.98652283
102TAF15_26573619_Chip-Seq_HEK293_Human0.98356772
103BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97742441
104NCOR_22424771_ChIP-Seq_293T_Human0.97569618
105RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97345099
106* EZH2_27294783_Chip-Seq_NPCs_Mouse0.97296626
107GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96662749
108CBP_20019798_ChIP-Seq_JUKART_Human0.96646398
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96646398
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96494372
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96264658
112ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95978786
113SMRT_27268052_Chip-Seq_Bcells_Human0.95827286
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95652408
115SCL_19346495_ChIP-Seq_HPC-7_Human0.95627132
116KDM2B_26808549_Chip-Seq_JURKAT_Human0.95481392
117* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94825530
118SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.94799569
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94536546
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93400230
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93222372
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92353459
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92236599
124EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92078322
125ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91867838
126REST_21632747_ChIP-Seq_MESCs_Mouse0.90948124
127PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90914779
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90733483
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90191585
130GATA3_21878914_ChIP-Seq_MCF-7_Human0.90004563
131RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89946644
132* CRX_20693478_ChIP-Seq_RETINA_Mouse0.89717628
133* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89461051
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89267483
135RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88089710
136TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87789902
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87547343
138FOXA1_25329375_ChIP-Seq_VCAP_Human0.87305466
139FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87305466
140P300_19829295_ChIP-Seq_ESCs_Human0.87102475
141TAF2_19829295_ChIP-Seq_ESCs_Human0.85635310
142CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85146037
143* FOXP3_21729870_ChIP-Seq_TREG_Human0.85037299
144* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.84849172
145* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83031497
146PU_27001747_Chip-Seq_BMDM_Mouse0.82821748
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82581361
148AR_20517297_ChIP-Seq_VCAP_Human0.82409827
149KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79912869
150TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.78522385
151SA1_27219007_Chip-Seq_ERYTHROID_Human0.78241293
152EZH2_22144423_ChIP-Seq_EOC_Human0.78033641
153FLI1_27457419_Chip-Seq_LIVER_Mouse0.77062378
154DNAJC2_21179169_ChIP-ChIP_NT2_Human0.74564118
155CTCF_27219007_Chip-Seq_ERYTHROID_Human0.72638786
156GATA1_19941827_ChIP-Seq_MEL_Mouse0.71690949
157* SPI1_20517297_ChIP-Seq_HL60_Human0.70989749
158SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69722060
159PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66875746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.24220296
2MP0003763_abnormal_thymus_physiology5.74220155
3MP0006082_CNS_inflammation4.66418007
4MP0009785_altered_susceptibility_to4.16493827
5MP0000685_abnormal_immune_system3.75620611
6MP0001835_abnormal_antigen_presentation3.68763795
7MP0003724_increased_susceptibility_to3.34683027
8MP0005387_immune_system_phenotype3.02257102
9MP0001790_abnormal_immune_system3.02257102
10MP0002405_respiratory_system_inflammati3.02158820
11MP0005025_abnormal_response_to3.01913534
12MP0001800_abnormal_humoral_immune2.99748640
13MP0002420_abnormal_adaptive_immunity2.98288186
14MP0001819_abnormal_immune_cell2.92706303
15MP0005000_abnormal_immune_tolerance2.89088546
16MP0002723_abnormal_immune_serum2.77790527
17MP0002398_abnormal_bone_marrow2.65746340
18MP0003329_amyloid_beta_deposits2.45282834
19MP0003866_abnormal_defecation2.42721684
20MP0000716_abnormal_immune_system2.35477321
21MP0002452_abnormal_antigen_presenting2.33794130
22MP0000703_abnormal_thymus_morphology2.25726501
23MP0003787_abnormal_imprinting2.22112543
24MP0002722_abnormal_immune_system2.15966483
25MP0001851_eye_inflammation2.15587074
26MP0002933_joint_inflammation2.04531767
27MP0009333_abnormal_splenocyte_physiolog2.04367144
28MP0002166_altered_tumor_susceptibility1.92888755
29MP0008877_abnormal_DNA_methylation1.91415443
30MP0000689_abnormal_spleen_morphology1.90840450
31MP0005075_abnormal_melanosome_morpholog1.90658576
32MP0004947_skin_inflammation1.87114220
33MP0000858_altered_metastatic_potential1.83764922
34MP0000569_abnormal_digit_pigmentation1.82561559
35MP0002132_abnormal_respiratory_system1.82213812
36MP0002429_abnormal_blood_cell1.81704726
37MP0003448_altered_tumor_morphology1.77579505
38MP0003436_decreased_susceptibility_to1.72352392
39MP0002006_tumorigenesis1.72072002
40MP0010155_abnormal_intestine_physiology1.66680768
41MP0001986_abnormal_taste_sensitivity1.64787886
42MP0001845_abnormal_inflammatory_respons1.63922962
43MP0004130_abnormal_muscle_cell1.63102957
44MP0000604_amyloidosis1.62975084
45MP0002419_abnormal_innate_immunity1.60413290
46MP0003045_fibrosis1.50189057
47MP0005464_abnormal_platelet_physiology1.49676708
48MP0003195_calcinosis1.45437973
49MP0002148_abnormal_hypersensitivity_rea1.45022719
50MP0005310_abnormal_salivary_gland1.43362370
51MP0003646_muscle_fatigue1.39904409
52MP0001873_stomach_inflammation1.37768808
53MP0001853_heart_inflammation1.37548442
54MP0010352_gastrointestinal_tract_polyps1.37380278
55MP0002163_abnormal_gland_morphology1.37233591
56MP0002396_abnormal_hematopoietic_system1.29200661
57MP0008469_abnormal_protein_level1.24815454
58MP0005645_abnormal_hypothalamus_physiol1.22574143
59MP0002138_abnormal_hepatobiliary_system1.17299262
60MP0002102_abnormal_ear_morphology1.15989199
61MP0002693_abnormal_pancreas_physiology1.15260495
62MP0003011_delayed_dark_adaptation1.13054365
63MP0002277_abnormal_respiratory_mucosa1.12427371
64MP0005551_abnormal_eye_electrophysiolog1.10886927
65MP0002019_abnormal_tumor_incidence1.07900807
66MP0002909_abnormal_adrenal_gland1.06289166
67MP0005379_endocrine/exocrine_gland_phen1.06031628
68MP0004142_abnormal_muscle_tone1.05859490
69MP0001533_abnormal_skeleton_physiology1.03522163
70MP0008872_abnormal_physiological_respon1.02256261
71MP0002822_catalepsy1.01960926
72MP0003880_abnormal_central_pattern1.01321404
73MP0000920_abnormal_myelination0.99937462
74MP0001968_abnormal_touch/_nociception0.99862908
75MP0009763_increased_sensitivity_to0.98789628
76MP0001849_ear_inflammation0.96344056
77MP0003300_gastrointestinal_ulcer0.96239292
78MP0004510_myositis0.95113234
79MP0009384_cardiac_valve_regurgitation0.91124864
80MP0001919_abnormal_reproductive_system0.90932958
81MP0009745_abnormal_behavioral_response0.90163309
82MP0001905_abnormal_dopamine_level0.89971214
83MP0004885_abnormal_endolymph0.89200474
84MP0000372_irregular_coat_pigmentation0.89069042
85MP0003879_abnormal_hair_cell0.86487694
86MP0004381_abnormal_hair_follicle0.85935499
87MP0004145_abnormal_muscle_electrophysio0.85821689
88MP0001765_abnormal_ion_homeostasis0.85538324
89MP0004043_abnormal_pH_regulation0.85185122
90MP0005174_abnormal_tail_pigmentation0.83003542
91MP0005646_abnormal_pituitary_gland0.82719758
92MP0004134_abnormal_chest_morphology0.82212436
93MP0002837_dystrophic_cardiac_calcinosis0.80185266
94MP0005166_decreased_susceptibility_to0.79556816
95MP0002928_abnormal_bile_duct0.77437442
96MP0005389_reproductive_system_phenotype0.76965588
97MP0001485_abnormal_pinna_reflex0.75919048
98MP0000465_gastrointestinal_hemorrhage0.74443128
99MP0005023_abnormal_wound_healing0.73475175
100MP0003252_abnormal_bile_duct0.69899461
101MP0002736_abnormal_nociception_after0.69303713
102MP0002095_abnormal_skin_pigmentation0.68447970
103MP0003828_pulmonary_edema0.67763874
104MP0004883_abnormal_blood_vessel0.67072798
105MP0005253_abnormal_eye_physiology0.67057026
106MP0001501_abnormal_sleep_pattern0.64833998
107MP0003878_abnormal_ear_physiology0.64381283
108MP0005377_hearing/vestibular/ear_phenot0.64381283
109MP0005058_abnormal_lysosome_morphology0.63020230
110MP0008873_increased_physiological_sensi0.63004649
111MP0003638_abnormal_response/metabolism_0.62954099
112MP0000477_abnormal_intestine_morphology0.61806863
113MP0009765_abnormal_xenobiotic_induced0.61406611
114MP0002876_abnormal_thyroid_physiology0.60204283
115MP0009764_decreased_sensitivity_to0.60075871
116MP0003172_abnormal_lysosome_physiology0.59620776
117MP0003303_peritoneal_inflammation0.59620082
118MP0008770_decreased_survivor_rate0.58748173
119MP0002998_abnormal_bone_remodeling0.57881449
120MP0003950_abnormal_plasma_membrane0.57797469
121MP0000490_abnormal_crypts_of0.57652680
122MP0003633_abnormal_nervous_system0.57249154
123MP0003718_maternal_effect0.50909758
124MP0008569_lethality_at_weaning0.49899264
125MP0001188_hyperpigmentation0.49539482
126MP0005076_abnormal_cell_differentiation0.45838680
127MP0002083_premature_death0.44604272
128MP0001191_abnormal_skin_condition0.42631427
129MP0008875_abnormal_xenobiotic_pharmacok0.42381814
130MP0008007_abnormal_cellular_replicative0.41191499
131MP0005083_abnormal_biliary_tract0.40459627
132MP0002009_preneoplasia0.39924577
133MP0008874_decreased_physiological_sensi0.39562303
134MP0002064_seizures0.39492363
135MP0000609_abnormal_liver_physiology0.36221149
136MP0001664_abnormal_digestion0.36121788
137MP0001348_abnormal_lacrimal_gland0.35919569
138MP0003943_abnormal_hepatobiliary_system0.35918215
139MP0001243_abnormal_dermal_layer0.35630357
140MP0000343_altered_response_to0.34552094
141MP0002136_abnormal_kidney_physiology0.34324270
142MP0000015_abnormal_ear_pigmentation0.34189405
143MP0006072_abnormal_retinal_apoptosis0.34035752
144MP0005423_abnormal_somatic_nervous0.33913029
145MP0003077_abnormal_cell_cycle0.32984536
146MP0005395_other_phenotype0.32534674

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)7.86731086
2Increased IgM level (HP:0003496)7.66451375
3Severe combined immunodeficiency (HP:0004430)6.80850386
4T lymphocytopenia (HP:0005403)6.24213478
5IgG deficiency (HP:0004315)6.11064049
6Abnormality of T cell number (HP:0011839)5.99370516
7Combined immunodeficiency (HP:0005387)5.97664573
8Nasal polyposis (HP:0100582)5.28227609
9Abnormality of T cells (HP:0002843)5.24466192
10Eczematoid dermatitis (HP:0000976)4.92029640
11IgM deficiency (HP:0002850)4.57681343
12Recurrent bronchitis (HP:0002837)4.52752512
13Autoimmune hemolytic anemia (HP:0001890)4.34706005
14Abnormality of the nasal mucosa (HP:0000433)4.26229421
15Abnormality of T cell physiology (HP:0011840)4.20625986
16Chronic diarrhea (HP:0002028)4.04818494
17Elevated erythrocyte sedimentation rate (HP:0003565)3.89584998
18Gastrointestinal infarctions (HP:0005244)3.86326319
19Recurrent fungal infections (HP:0002841)3.79598341
20Thyroiditis (HP:0100646)3.78448454
21Panhypogammaglobulinemia (HP:0003139)3.78001303
22Chronic mucocutaneous candidiasis (HP:0002728)3.63959472
23Recurrent cutaneous fungal infections (HP:0011370)3.63959472
24Joint swelling (HP:0001386)3.60837536
25Hypoproteinemia (HP:0003075)3.59506522
26Gingivitis (HP:0000230)3.54631766
27Chronic otitis media (HP:0000389)3.48985738
28Hypergammaglobulinemia (HP:0010702)3.45729445
29Congenital stationary night blindness (HP:0007642)3.44051494
30Hypoplasia of the thymus (HP:0000778)3.37014846
31IgA deficiency (HP:0002720)3.30412455
32Recurrent bacterial skin infections (HP:0005406)3.29318264
33Lymphopenia (HP:0001888)3.23332221
34Abnormality of eosinophils (HP:0001879)3.17713547
35Abnormality of cells of the lymphoid lineage (HP:0012140)3.14147742
36Radial bowing (HP:0002986)3.04680319
37Hepatitis (HP:0012115)3.00198292
38Recurrent abscess formation (HP:0002722)2.95735016
39Meningitis (HP:0001287)2.94845467
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.94147141
41Keratoconjunctivitis (HP:0001096)2.92992633
42Abnormal rod and cone electroretinograms (HP:0008323)2.89200261
43Leukocytosis (HP:0001974)2.85545253
44Chronic obstructive pulmonary disease (HP:0006510)2.82716300
45Obstructive lung disease (HP:0006536)2.82716300
46Amyotrophic lateral sclerosis (HP:0007354)2.81567744
47Aplastic anemia (HP:0001915)2.73297640
48Myositis (HP:0100614)2.71628543
49Frequent falls (HP:0002359)2.70826192
50Keratoconjunctivitis sicca (HP:0001097)2.67854058
51Encephalitis (HP:0002383)2.66806860
52Mediastinal lymphadenopathy (HP:0100721)2.66779204
53Agammaglobulinemia (HP:0004432)2.64891808
54Abnormality of the renal cortex (HP:0011035)2.52720026
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.51764456
56Hypoalbuminemia (HP:0003073)2.51325703
57Abnormal albumin level (HP:0012116)2.51325703
58Abnormality of binocular vision (HP:0011514)2.49078258
59Diplopia (HP:0000651)2.49078258
60Recurrent sinusitis (HP:0011108)2.48857921
61Hypochromic microcytic anemia (HP:0004840)2.47666427
62Bronchitis (HP:0012387)2.45622269
63Neuroendocrine neoplasm (HP:0100634)2.44866851
64Genetic anticipation (HP:0003743)2.43569069
65Recurrent viral infections (HP:0004429)2.42729791
66Pancreatic cysts (HP:0001737)2.41447646
67Asplenia (HP:0001746)2.36343558
68Progressive inability to walk (HP:0002505)2.35490024
69Short tibia (HP:0005736)2.33618255
70Agitation (HP:0000713)2.32107952
71Pancreatic fibrosis (HP:0100732)2.31948393
72Vasculitis (HP:0002633)2.31819935
73Granulocytopenia (HP:0001913)2.29488128
74Pustule (HP:0200039)2.29416773
75Hemiplegia (HP:0002301)2.27205133
76Aplasia/Hypoplasia of the spleen (HP:0010451)2.26062517
77Recurrent gram-negative bacterial infections (HP:0005420)2.25373399
78Increased intramyocellular lipid droplets (HP:0012240)2.24840974
79Dyskinesia (HP:0100660)2.23887247
80Recurrent skin infections (HP:0001581)2.23884986
81Tetraplegia (HP:0002445)2.21246586
82Progressive cerebellar ataxia (HP:0002073)2.16477595
83Abnormality of macrophages (HP:0004311)2.16356474
84Hemoptysis (HP:0002105)2.15542548
85Attenuation of retinal blood vessels (HP:0007843)2.14536721
86Abnormality of oral frenula (HP:0000190)2.14086370
87Pulmonary fibrosis (HP:0002206)2.13957606
88Pulmonary infiltrates (HP:0002113)2.13130314
89Lymphoma (HP:0002665)2.11880934
90Inflammation of the large intestine (HP:0002037)2.11174035
91Fibular hypoplasia (HP:0003038)2.09414854
92Abnormal gallbladder physiology (HP:0012438)2.08142808
93Cholecystitis (HP:0001082)2.08142808
94Hypochromic anemia (HP:0001931)2.06484071
95Prolonged bleeding time (HP:0003010)2.00046142
96Increased IgE level (HP:0003212)1.99894717
97Abolished electroretinogram (ERG) (HP:0000550)1.97177092
98Gingival bleeding (HP:0000225)1.95872458
99Gastrointestinal inflammation (HP:0004386)1.95386560
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.95281842
101Autoimmune thrombocytopenia (HP:0001973)1.94853113
102Abnormality of the fingertips (HP:0001211)1.94596516
103Chest pain (HP:0100749)1.94409999
104Stomach cancer (HP:0012126)1.94391751
105Spondylolisthesis (HP:0003302)1.94091122
106Chronic sinusitis (HP:0011109)1.93428090
107Constricted visual fields (HP:0001133)1.93359622
108Retrobulbar optic neuritis (HP:0100654)1.93017882
109Optic neuritis (HP:0100653)1.93017882
110Amaurosis fugax (HP:0100576)1.91980103
111True hermaphroditism (HP:0010459)1.90810888
112Recurrent otitis media (HP:0000403)1.89968135
113Abnormality of B cell number (HP:0010975)1.89233025
114Spontaneous hematomas (HP:0007420)1.89061716
115Acute hepatic failure (HP:0006554)1.88599139
116Renal cortical cysts (HP:0000803)1.88046051
117Eosinophilia (HP:0001880)1.87763839
118Gangrene (HP:0100758)1.87458850
119Increased muscle lipid content (HP:0009058)1.86516097
120Urinary urgency (HP:0000012)1.86446704
121Papilledema (HP:0001085)1.85638486
122Vacuolated lymphocytes (HP:0001922)1.85001574
123Pulmonary embolism (HP:0002204)1.84263582
124Episodic fever (HP:0001954)1.81746433
125Epistaxis (HP:0000421)1.81188530
126Orchitis (HP:0100796)1.80857232
127Menstrual irregularities (HP:0000858)1.76189755
128Bowing of the arm (HP:0006488)1.75560577
129Bowed forearm bones (HP:0003956)1.75560577
130Abnormal drinking behavior (HP:0030082)1.74683756
131Polydipsia (HP:0001959)1.74683756
132Oral leukoplakia (HP:0002745)1.74572775
133Hematochezia (HP:0002573)1.74456542
134Anorexia (HP:0002039)1.74190025
135Microcytic anemia (HP:0001935)1.73180187
136Bronchiectasis (HP:0002110)1.72925738
137Alveolar cell carcinoma (HP:0006519)1.71449836
138Arterial thrombosis (HP:0004420)1.68486342
139Hyperlipoproteinemia (HP:0010980)1.67557444
140Cellular immunodeficiency (HP:0005374)1.66748562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.23648187
2TESK25.83051850
3KDR4.45543615
4MAP4K14.34994967
5MAP3K124.33938696
6FRK3.62697847
7ZAP703.09025980
8TESK13.02382000
9ITK2.68218616
10TAOK32.35694150
11JAK12.29332581
12ADRBK22.18942387
13BUB12.17378534
14LCK2.17328459
15IKBKE1.91999708
16IRAK41.88067708
17JAK31.85877573
18LIMK11.85353199
19STK101.71555579
20GRK61.69891841
21CAMKK21.65330045
22PRKCQ1.63510525
23MUSK1.60338663
24FGFR11.58013189
25RIPK41.56395506
26TYK21.56056006
27MAP2K61.49563836
28CASK1.47823789
29TBK11.40605288
30TNK21.39478645
31CSK1.38495187
32WNK31.34992188
33BTK1.25405988
34EPHA31.24807539
35EIF2AK11.23322940
36PIK3CG1.20683565
37HCK1.19159924
38GRK11.18870362
39FGFR41.15126354
40CLK11.09378375
41MYLK1.05394607
42PRKCH1.02549013
43MST41.01736146
44TEC1.01694943
45LYN0.99090574
46MAPK130.97837945
47SYK0.97439637
48MAP4K20.91042458
49PTK2B0.89976570
50PINK10.89702795
51FES0.87991608
52ACVR1B0.86641305
53WNK40.85418168
54BLK0.85036188
55CAMKK10.84204848
56EIF2AK30.83666265
57IRAK20.79548411
58EPHB10.78266603
59DAPK30.78023280
60RAF10.77720428
61ADRBK10.77126749
62ALK0.76316536
63FYN0.75372469
64INSR0.73303834
65SIK20.72971680
66CDK190.72686603
67DAPK10.71204536
68MARK30.70655718
69DMPK0.68666297
70LRRK20.67011949
71MAP3K110.65868353
72IGF1R0.65231998
73IRAK10.64112946
74GRK50.63240028
75PASK0.62714118
76NLK0.62221712
77MAP3K40.60544016
78NTRK20.59537715
79GRK70.59029308
80OXSR10.56672480
81STK110.55889599
82SGK20.55527070
83TRPM70.54840990
84INSRR0.53468140
85PAK30.52966042
86TLK10.49395695
87NUAK10.49008341
88ZAK0.48324282
89MAP3K100.47730788
90SGK2230.46063946
91SGK4940.46063946
92ROCK10.45981625
93MAP2K30.45892346
94SIK30.45398760
95BMPR1B0.45291593
96NTRK30.44556691
97SRC0.43950627
98FGFR20.43075631
99ERN10.42689171
100ILK0.42549800
101ARAF0.41781659
102IKBKB0.40880607
103MAP2K70.39987431
104MAP3K70.39866854
105NEK90.39855090
106PIM20.39232967
107FGR0.36654574
108BMPR20.33580225
109MAPKAPK30.33314247
110JAK20.33075919
111TTN0.32729876
112SIK10.32676961
113MAP3K30.32423480
114SGK30.32003541
115STK380.31982562
116PRKG20.31660950
117ERBB20.31520240
118MAP3K140.30777416
119HIPK20.30742288
120STK160.30693110
121CDK90.30664907
122MARK20.29855156
123FGFR30.29465923
124SCYL20.29052467
125PIM10.29014711
126MAP3K130.26144904
127CSF1R0.21992433
128ROCK20.20584509
129PRKCD0.20577708
130ABL10.19489733
131MAP3K50.18990151
132PRKD20.16753791
133PDK10.16264199
134RPS6KA60.16044438
135BRD40.13965014
136TAOK10.13961934
137CSNK1G30.13037809
138DAPK20.12920625
139RPS6KA40.12672550
140CSNK1A1L0.12259382
141PRKCA0.11049045
142CSNK1A10.10817128
143KIT0.09547231
144TGFBR20.09015711
145CDK30.08766896
146PRKCI0.08443588

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.34658192
2Graft-versus-host disease_Homo sapiens_hsa053325.22758633
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.99016011
4Allograft rejection_Homo sapiens_hsa053304.10402053
5T cell receptor signaling pathway_Homo sapiens_hsa046603.62123097
6Viral myocarditis_Homo sapiens_hsa054163.34843091
7Antigen processing and presentation_Homo sapiens_hsa046123.29614544
8Autoimmune thyroid disease_Homo sapiens_hsa053203.00557633
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.57631322
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.39927333
11Measles_Homo sapiens_hsa051622.27775813
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.14278126
13Asthma_Homo sapiens_hsa053102.03280301
14Phototransduction_Homo sapiens_hsa047441.92977352
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.86255386
16Leishmaniasis_Homo sapiens_hsa051401.80433009
17B cell receptor signaling pathway_Homo sapiens_hsa046621.79935961
18Hematopoietic cell lineage_Homo sapiens_hsa046401.54226904
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48925097
20Malaria_Homo sapiens_hsa051441.47497685
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.47052688
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41842419
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38100022
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.36005109
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20405533
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20092452
27VEGF signaling pathway_Homo sapiens_hsa043701.20024841
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.13954526
29Shigellosis_Homo sapiens_hsa051311.12155926
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08611020
31Osteoclast differentiation_Homo sapiens_hsa043801.07916030
32Chemokine signaling pathway_Homo sapiens_hsa040621.07357436
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05585530
34Apoptosis_Homo sapiens_hsa042101.05479394
35Oxidative phosphorylation_Homo sapiens_hsa001901.03352138
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01570097
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01520321
38Type I diabetes mellitus_Homo sapiens_hsa049401.01449556
39Colorectal cancer_Homo sapiens_hsa052100.99198352
40Linoleic acid metabolism_Homo sapiens_hsa005910.96426846
41Ribosome_Homo sapiens_hsa030100.95857141
42Toxoplasmosis_Homo sapiens_hsa051450.88037071
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87269417
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85385995
45Pancreatic cancer_Homo sapiens_hsa052120.83468336
46Nitrogen metabolism_Homo sapiens_hsa009100.83161555
47Herpes simplex infection_Homo sapiens_hsa051680.80907814
48HTLV-I infection_Homo sapiens_hsa051660.78035573
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77728104
50Staphylococcus aureus infection_Homo sapiens_hsa051500.77143932
51Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74824411
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71604410
53Parkinsons disease_Homo sapiens_hsa050120.69494698
54Ether lipid metabolism_Homo sapiens_hsa005650.68973264
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65473869
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65362246
57Taste transduction_Homo sapiens_hsa047420.62231131
58Serotonergic synapse_Homo sapiens_hsa047260.60563191
59Adherens junction_Homo sapiens_hsa045200.59520342
60Platelet activation_Homo sapiens_hsa046110.57647770
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57642246
62GABAergic synapse_Homo sapiens_hsa047270.57370477
63Type II diabetes mellitus_Homo sapiens_hsa049300.55112332
64Salmonella infection_Homo sapiens_hsa051320.54626027
65Spliceosome_Homo sapiens_hsa030400.54532464
66Pentose phosphate pathway_Homo sapiens_hsa000300.54045397
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53470904
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52990436
69Renin secretion_Homo sapiens_hsa049240.50603967
70Collecting duct acid secretion_Homo sapiens_hsa049660.50232305
71Cardiac muscle contraction_Homo sapiens_hsa042600.49811220
72Phagosome_Homo sapiens_hsa041450.49239639
73Endocytosis_Homo sapiens_hsa041440.48363090
74African trypanosomiasis_Homo sapiens_hsa051430.47195139
75Cholinergic synapse_Homo sapiens_hsa047250.46963293
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46891917
77Alzheimers disease_Homo sapiens_hsa050100.45885276
78Circadian entrainment_Homo sapiens_hsa047130.45689505
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45422201
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.44338118
81Caffeine metabolism_Homo sapiens_hsa002320.43385916
82ABC transporters_Homo sapiens_hsa020100.42473924
83Butanoate metabolism_Homo sapiens_hsa006500.42318596
84Hepatitis B_Homo sapiens_hsa051610.42054585
85Rap1 signaling pathway_Homo sapiens_hsa040150.39130246
86p53 signaling pathway_Homo sapiens_hsa041150.38404162
87Ovarian steroidogenesis_Homo sapiens_hsa049130.37672971
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.37368641
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37206393
90Pertussis_Homo sapiens_hsa051330.35321810
91Arachidonic acid metabolism_Homo sapiens_hsa005900.35025231
92Proteasome_Homo sapiens_hsa030500.34699323
93Insulin secretion_Homo sapiens_hsa049110.33905260
94Dopaminergic synapse_Homo sapiens_hsa047280.33753763
95Calcium signaling pathway_Homo sapiens_hsa040200.33628736
96Chemical carcinogenesis_Homo sapiens_hsa052040.32805826
97Tuberculosis_Homo sapiens_hsa051520.30783528
98Epstein-Barr virus infection_Homo sapiens_hsa051690.30373259
99DNA replication_Homo sapiens_hsa030300.29616108
100Hepatitis C_Homo sapiens_hsa051600.29519959
101Lysosome_Homo sapiens_hsa041420.29309531
102Axon guidance_Homo sapiens_hsa043600.27913394
103Acute myeloid leukemia_Homo sapiens_hsa052210.27379198
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27292905
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.27043311
106TNF signaling pathway_Homo sapiens_hsa046680.26910435
107Viral carcinogenesis_Homo sapiens_hsa052030.25852572
108Legionellosis_Homo sapiens_hsa051340.25683643
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25656987
110Influenza A_Homo sapiens_hsa051640.24071245
111Base excision repair_Homo sapiens_hsa034100.23746822
112Morphine addiction_Homo sapiens_hsa050320.22825539
113Long-term potentiation_Homo sapiens_hsa047200.21247591
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21234644
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20820948
116MAPK signaling pathway_Homo sapiens_hsa040100.19412884
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18978878
118Other glycan degradation_Homo sapiens_hsa005110.18837878
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17273872
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.16246999
121Rheumatoid arthritis_Homo sapiens_hsa053230.14913798
122Regulation of autophagy_Homo sapiens_hsa041400.14495560
123Gastric acid secretion_Homo sapiens_hsa049710.12944316
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12684238
125Non-small cell lung cancer_Homo sapiens_hsa052230.11906515
126Nicotine addiction_Homo sapiens_hsa050330.09130650
127Inositol phosphate metabolism_Homo sapiens_hsa005620.08606284
128RNA degradation_Homo sapiens_hsa030180.07897903
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.06576806
130Nucleotide excision repair_Homo sapiens_hsa034200.05420822
131Protein export_Homo sapiens_hsa030600.05279139
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.04876820
133Oxytocin signaling pathway_Homo sapiens_hsa049210.03958955
134Basal transcription factors_Homo sapiens_hsa030220.03796125
135Focal adhesion_Homo sapiens_hsa045100.03664830
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.03349248
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.00996939
138Ras signaling pathway_Homo sapiens_hsa040140.00854304
139Olfactory transduction_Homo sapiens_hsa04740-0.0356254
140cAMP signaling pathway_Homo sapiens_hsa04024-0.0289423

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