SAMD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron recognition (GO:0008038)4.87706569
2axonal fasciculation (GO:0007413)4.66978850
3dendritic spine morphogenesis (GO:0060997)4.65717776
4neuron cell-cell adhesion (GO:0007158)4.39994086
5behavioral response to nicotine (GO:0035095)4.16586753
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.13905625
7vocalization behavior (GO:0071625)4.09489118
8negative regulation of axon guidance (GO:1902668)4.04446341
9neuronal action potential propagation (GO:0019227)4.01619862
10axon extension involved in axon guidance (GO:0048846)3.94603019
11neuron projection extension involved in neuron projection guidance (GO:1902284)3.94603019
12protein localization to synapse (GO:0035418)3.84679232
13layer formation in cerebral cortex (GO:0021819)3.76215456
14innervation (GO:0060384)3.74870041
15regulation of axon guidance (GO:1902667)3.68376589
16response to pheromone (GO:0019236)3.67675940
17L-fucose catabolic process (GO:0042355)3.66685551
18fucose catabolic process (GO:0019317)3.66685551
19L-fucose metabolic process (GO:0042354)3.66685551
20glutamate receptor signaling pathway (GO:0007215)3.65084250
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.62227600
22retinal ganglion cell axon guidance (GO:0031290)3.59258530
23positive regulation of synapse assembly (GO:0051965)3.53531138
24postsynaptic membrane organization (GO:0001941)3.49179253
25regulation of glutamate receptor signaling pathway (GO:1900449)3.47941119
26nucleobase catabolic process (GO:0046113)3.45045885
27cellular ketone body metabolic process (GO:0046950)3.40716428
28axon extension (GO:0048675)3.38454125
29presynaptic membrane assembly (GO:0097105)3.38328955
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.33698204
31cell migration in hindbrain (GO:0021535)3.32014857
32dopaminergic neuron differentiation (GO:0071542)3.31025862
33negative regulation of axon extension involved in axon guidance (GO:0048843)3.29484283
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.23151841
35regulation of short-term neuronal synaptic plasticity (GO:0048172)3.21183248
36regulation of axon extension involved in axon guidance (GO:0048841)3.18590054
37dendritic spine organization (GO:0097061)3.15878416
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.15443830
39synaptic transmission, glutamatergic (GO:0035249)3.15330138
40regulation of synapse assembly (GO:0051963)3.15137133
41negative regulation of axon extension (GO:0030517)3.13958869
42motor neuron axon guidance (GO:0008045)3.12591166
43protein localization to cilium (GO:0061512)3.10471060
44negative chemotaxis (GO:0050919)3.08408265
45neuron-neuron synaptic transmission (GO:0007270)3.07325401
46central nervous system projection neuron axonogenesis (GO:0021952)3.07027766
47endocrine pancreas development (GO:0031018)3.05450643
48ketone body metabolic process (GO:1902224)3.04494969
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98768547
50detection of light stimulus involved in visual perception (GO:0050908)2.98340376
51detection of light stimulus involved in sensory perception (GO:0050962)2.98340376
52gamma-aminobutyric acid signaling pathway (GO:0007214)2.97386623
53cornea development in camera-type eye (GO:0061303)2.95224308
54regulation of dendritic spine morphogenesis (GO:0061001)2.95197760
55limb bud formation (GO:0060174)2.95179571
56indole-containing compound catabolic process (GO:0042436)2.93413039
57indolalkylamine catabolic process (GO:0046218)2.93413039
58tryptophan catabolic process (GO:0006569)2.93413039
59presynaptic membrane organization (GO:0097090)2.92557652
60neuron remodeling (GO:0016322)2.91398171
61detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.91096899
62proline transport (GO:0015824)2.91087892
63exploration behavior (GO:0035640)2.90587605
64transmission of nerve impulse (GO:0019226)2.90101186
65establishment of planar polarity (GO:0001736)2.89697117
66establishment of tissue polarity (GO:0007164)2.89697117
67indolalkylamine metabolic process (GO:0006586)2.88510227
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.87959826
69gamma-aminobutyric acid transport (GO:0015812)2.87293120
70neuron projection extension (GO:1990138)2.87131762
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.86083690
72response to histamine (GO:0034776)2.85121554
73cochlea development (GO:0090102)2.84310812
74kidney morphogenesis (GO:0060993)2.84153534
75water-soluble vitamin biosynthetic process (GO:0042364)2.82553541
76behavioral response to ethanol (GO:0048149)2.82319046
77neuronal action potential (GO:0019228)2.81934722
78synaptic vesicle exocytosis (GO:0016079)2.81912834
79regulation of action potential (GO:0098900)2.80583808
80regulation of long-term neuronal synaptic plasticity (GO:0048169)2.79896567
81behavioral fear response (GO:0001662)2.78538682
82behavioral defense response (GO:0002209)2.78538682
83ephrin receptor signaling pathway (GO:0048013)2.76907873
84negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76574699
85chondrocyte development (GO:0002063)2.76465233
86epithelial cilium movement (GO:0003351)2.74656593
87regulation of synapse organization (GO:0050807)2.74126222
88exogenous drug catabolic process (GO:0042738)2.73425651
89synapse assembly (GO:0007416)2.72630678
90regulation of glucokinase activity (GO:0033131)2.70914284
91regulation of hexokinase activity (GO:1903299)2.70914284
92positive regulation of glycolytic process (GO:0045821)2.70886376
93positive regulation of meiosis (GO:0045836)2.68762762
94startle response (GO:0001964)2.68565228
95drug catabolic process (GO:0042737)2.67256938
96synapse organization (GO:0050808)2.66775648
97S-adenosylmethionine metabolic process (GO:0046500)2.66543387
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.66162257
99positive regulation of gastrulation (GO:2000543)2.65973936
100intraciliary transport (GO:0042073)2.65577453
101positive regulation of growth hormone secretion (GO:0060124)2.65426559
102tryptophan metabolic process (GO:0006568)2.64824884
103somite rostral/caudal axis specification (GO:0032525)2.64647490
104establishment of nucleus localization (GO:0040023)2.64451435
105photoreceptor cell maintenance (GO:0045494)2.64290578
106reflex (GO:0060004)2.61938773
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.60865373
108regulation of respiratory system process (GO:0044065)2.60062792
109cerebral cortex radially oriented cell migration (GO:0021799)2.59613866
110regulation of acrosome reaction (GO:0060046)2.59030673
111dendrite morphogenesis (GO:0048813)2.58584420
112positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.58532065
113regulation of synaptic transmission, glutamatergic (GO:0051966)2.58125720
114regulation of protein kinase A signaling (GO:0010738)2.55699123
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.55081316
116auditory behavior (GO:0031223)2.54500045
117fear response (GO:0042596)2.54431882
118regulation of synapse structural plasticity (GO:0051823)2.54367061
119regulation of postsynaptic membrane potential (GO:0060078)2.54304372
120cell-cell junction maintenance (GO:0045217)2.54134014
121positive regulation of synaptic transmission, GABAergic (GO:0032230)2.53429970
122positive regulation of meiotic cell cycle (GO:0051446)2.53302179
123neuronal ion channel clustering (GO:0045161)2.53126565
124glycerophospholipid catabolic process (GO:0046475)2.52377298
125regulation of respiratory gaseous exchange (GO:0043576)2.52250626
126regulation of synaptic vesicle exocytosis (GO:2000300)2.51778832
127righting reflex (GO:0060013)2.51681491
128cAMP-mediated signaling (GO:0019933)2.51412998
129pyrimidine nucleobase catabolic process (GO:0006208)2.51173239
130inner ear receptor cell development (GO:0060119)2.50352805
131regulation of dendritic spine development (GO:0060998)2.50318566
132glutamate secretion (GO:0014047)2.50297580
133negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49900758
134nitric oxide mediated signal transduction (GO:0007263)2.49394334
135positive regulation of dendritic spine development (GO:0060999)2.49110621
136regulation of excitatory postsynaptic membrane potential (GO:0060079)2.49066528
137regulation of neuronal synaptic plasticity (GO:0048168)2.48522178
138lateral sprouting from an epithelium (GO:0060601)2.48413266
139regulation of axon extension (GO:0030516)2.47318326
140central nervous system neuron axonogenesis (GO:0021955)2.47181871
141regulation of vesicle fusion (GO:0031338)2.46583867
142atrial cardiac muscle cell action potential (GO:0086014)2.46030605
143glandular epithelial cell differentiation (GO:0002067)2.44931691
144neurotransmitter-gated ion channel clustering (GO:0072578)2.44482039
145retinal cone cell development (GO:0046549)2.44113406
146locomotory exploration behavior (GO:0035641)2.43862763
147cilium organization (GO:0044782)2.39376998
148inner ear receptor stereocilium organization (GO:0060122)2.38639698
149axoneme assembly (GO:0035082)2.38052195
150positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.37523181
151protein polyglutamylation (GO:0018095)2.36764743
152insulin secretion (GO:0030073)2.36253554
153artery development (GO:0060840)2.35719741
154type B pancreatic cell development (GO:0003323)2.35628394
155nodal signaling pathway (GO:0038092)2.34305322
156establishment of protein localization to Golgi (GO:0072600)2.33885707
157cilium assembly (GO:0042384)2.33626985
158oxidative demethylation (GO:0070989)2.32926494
159action potential (GO:0001508)2.30876441
160cilium morphogenesis (GO:0060271)2.29636913
161heme transport (GO:0015886)2.29149118
162piRNA metabolic process (GO:0034587)2.28698772
163indole-containing compound metabolic process (GO:0042430)2.27744528
164signal transduction involved in regulation of gene expression (GO:0023019)2.27723178
165negative regulation of mast cell activation (GO:0033004)2.27232075
166pancreas development (GO:0031016)2.26778495
167response to dietary excess (GO:0002021)2.26627951
168polyol catabolic process (GO:0046174)2.26058541
169appendage development (GO:0048736)2.25461262
170limb development (GO:0060173)2.25461262
171magnesium ion transport (GO:0015693)2.24579525
172photoreceptor cell development (GO:0042461)2.24520343
173inositol phosphate catabolic process (GO:0071545)2.24343177
174calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.23949439
175smoothened signaling pathway (GO:0007224)2.23189201
176phenylpropanoid metabolic process (GO:0009698)2.22505712
177alanine transport (GO:0032328)2.21782510
178arginine metabolic process (GO:0006525)2.21261546
179regulation of type B pancreatic cell apoptotic process (GO:2000674)2.20823227
180positive regulation of embryonic development (GO:0040019)2.19665748
181fucosylation (GO:0036065)2.18915778
182calcium ion import (GO:0070509)2.18814615
183primary amino compound metabolic process (GO:1901160)2.18190662
184hindbrain development (GO:0030902)2.17680999
185aromatic amino acid family catabolic process (GO:0009074)2.17653359
186purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.17481548
1873-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.17481548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.14623513
2GBX2_23144817_ChIP-Seq_PC3_Human3.45741981
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07445518
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01856249
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98728732
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.95452296
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.90252391
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.89402905
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78939250
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78939250
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.71790772
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69373838
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66244276
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61077609
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45488401
16TAF15_26573619_Chip-Seq_HEK293_Human2.32143069
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26222512
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.25635298
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.17834399
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.17026634
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.14946327
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13598366
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12680210
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09489593
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08516056
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.96935691
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.94743078
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91155975
29AR_21572438_ChIP-Seq_LNCaP_Human1.91032036
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87071216
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85341926
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.81228280
33* P300_19829295_ChIP-Seq_ESCs_Human1.76335874
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75087505
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73070957
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70808905
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65596957
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65053409
39REST_21632747_ChIP-Seq_MESCs_Mouse1.62496164
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62171505
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.60066740
42RNF2_27304074_Chip-Seq_NSC_Mouse1.58754646
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58225934
44ZNF274_21170338_ChIP-Seq_K562_Hela1.57862078
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53333840
46SMAD4_21799915_ChIP-Seq_A2780_Human1.51890617
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51348888
48FUS_26573619_Chip-Seq_HEK293_Human1.50780146
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50437618
50CBP_20019798_ChIP-Seq_JUKART_Human1.50437618
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.50323179
52* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48496632
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.48452514
54* RING1B_27294783_Chip-Seq_ESCs_Mouse1.48319653
55TCF4_23295773_ChIP-Seq_U87_Human1.47755955
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42716167
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42507833
58TP53_18474530_ChIP-ChIP_U2OS_Human1.41867754
59VDR_22108803_ChIP-Seq_LS180_Human1.41829668
60* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40956551
61* RING1B_27294783_Chip-Seq_NPCs_Mouse1.40536446
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.40478470
63AHR_22903824_ChIP-Seq_MCF-7_Human1.38824067
64* DROSHA_22980978_ChIP-Seq_HELA_Human1.38579852
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38039281
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.35662353
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35555727
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34968649
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30886200
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30655370
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29818526
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29646024
73TP53_16413492_ChIP-PET_HCT116_Human1.29641696
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27571939
75IRF1_19129219_ChIP-ChIP_H3396_Human1.27254383
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.27014625
77AR_25329375_ChIP-Seq_VCAP_Human1.25548073
78* EZH2_27294783_Chip-Seq_NPCs_Mouse1.24275207
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24128636
80* TCF4_22108803_ChIP-Seq_LS180_Human1.23676498
81* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22472142
82IGF1R_20145208_ChIP-Seq_DFB_Human1.22388472
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.22344480
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21678050
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21664613
86P53_22387025_ChIP-Seq_ESCs_Mouse1.20347097
87* RARB_27405468_Chip-Seq_BRAIN_Mouse1.19751767
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19448196
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.18616117
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.18440171
91* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17996170
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.16604706
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.15299225
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14859645
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13059059
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12260353
97* EWS_26573619_Chip-Seq_HEK293_Human1.11519079
98SMAD4_21741376_ChIP-Seq_EPCs_Human1.11407050
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11318094
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11289736
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11016316
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09821237
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.09646769
104ERG_21242973_ChIP-ChIP_JURKAT_Human1.09613701
105FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08800448
106TP53_22573176_ChIP-Seq_HFKS_Human1.08166620
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07744408
108* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07716759
109* RUNX2_22187159_ChIP-Seq_PCA_Human1.07671029
110ER_23166858_ChIP-Seq_MCF-7_Human1.07325625
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06340169
112* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06318963
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04943306
114* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04302768
115* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04302768
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03857728
117SOX2_19829295_ChIP-Seq_ESCs_Human1.03652000
118NANOG_19829295_ChIP-Seq_ESCs_Human1.03652000
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03581782
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.03410354
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.03349476
122* FLI1_21867929_ChIP-Seq_TH2_Mouse1.03147799
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03013505
124CDX2_22108803_ChIP-Seq_LS180_Human1.02824913
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02266158
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01823490
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.01295572
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00885054
129* BCAT_22108803_ChIP-Seq_LS180_Human1.00319030
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.00264227
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99141479
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99140308
133JUN_21703547_ChIP-Seq_K562_Human0.99098453
134MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98731767
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98529463
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98068961
137POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97841933
138AR_19668381_ChIP-Seq_PC3_Human0.96952924
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95599187
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95599187
141* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95551298
142STAT3_23295773_ChIP-Seq_U87_Human0.95388380
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95366132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.96341624
2MP0004859_abnormal_synaptic_plasticity3.65796033
3MP0004270_analgesia3.03274950
4MP0003195_calcinosis2.94536145
5MP0003635_abnormal_synaptic_transmissio2.81532100
6MP0000778_abnormal_nervous_system2.57403993
7MP0001968_abnormal_touch/_nociception2.40568019
8MP0002063_abnormal_learning/memory/cond2.39817203
9MP0003283_abnormal_digestive_organ2.32634591
10MP0003787_abnormal_imprinting2.29537220
11MP0006276_abnormal_autonomic_nervous2.27036705
12MP0002184_abnormal_innervation2.20106842
13MP0003122_maternal_imprinting2.19469046
14MP0002736_abnormal_nociception_after2.18014292
15MP0009745_abnormal_behavioral_response2.11836044
16MP0008877_abnormal_DNA_methylation2.09689895
17MP0000537_abnormal_urethra_morphology2.09653974
18MP0001529_abnormal_vocalization2.09410436
19MP0009379_abnormal_foot_pigmentation2.08163164
20MP0002876_abnormal_thyroid_physiology2.07834564
21MP0002572_abnormal_emotion/affect_behav2.01592960
22MP0002734_abnormal_mechanical_nocicepti1.98346579
23MP0002064_seizures1.96826178
24MP0005551_abnormal_eye_electrophysiolog1.96241041
25MP0002234_abnormal_pharynx_morphology1.90905461
26MP0001188_hyperpigmentation1.87520492
27MP0004885_abnormal_endolymph1.87218512
28MP0002735_abnormal_chemical_nociception1.81257099
29MP0005423_abnormal_somatic_nervous1.77058754
30MP0000569_abnormal_digit_pigmentation1.72979692
31MP0002139_abnormal_hepatobiliary_system1.69214810
32MP0001501_abnormal_sleep_pattern1.69066334
33MP0001440_abnormal_grooming_behavior1.69057965
34MP0002272_abnormal_nervous_system1.65232760
35MP0005360_urolithiasis1.65134627
36MP0006072_abnormal_retinal_apoptosis1.62871874
37MP0004043_abnormal_pH_regulation1.60767063
38MP0001486_abnormal_startle_reflex1.58804430
39MP0000566_synostosis1.57523973
40MP0002102_abnormal_ear_morphology1.53613928
41MP0002928_abnormal_bile_duct1.52044516
42MP0005253_abnormal_eye_physiology1.51538722
43MP0003011_delayed_dark_adaptation1.50761093
44MP0001986_abnormal_taste_sensitivity1.50260199
45MP0000427_abnormal_hair_cycle1.49321592
46MP0006292_abnormal_olfactory_placode1.48416401
47MP0001944_abnormal_pancreas_morphology1.48024853
48MP0002557_abnormal_social/conspecific_i1.47681662
49MP0003252_abnormal_bile_duct1.45844388
50MP0005646_abnormal_pituitary_gland1.44239729
51MP0005085_abnormal_gallbladder_physiolo1.43971257
52MP0008875_abnormal_xenobiotic_pharmacok1.43862124
53MP0002067_abnormal_sensory_capabilities1.41862951
54MP0004858_abnormal_nervous_system1.41417931
55MP0009046_muscle_twitch1.40883001
56MP0010386_abnormal_urinary_bladder1.38233003
57MP0000955_abnormal_spinal_cord1.37131766
58MP0003718_maternal_effect1.36863245
59MP0005409_darkened_coat_color1.36220253
60MP0002751_abnormal_autonomic_nervous1.35719133
61MP0002282_abnormal_trachea_morphology1.33576400
62MP0003385_abnormal_body_wall1.32922267
63MP0010030_abnormal_orbit_morphology1.31526447
64MP0000383_abnormal_hair_follicle1.29959558
65MP0008961_abnormal_basal_metabolism1.29368617
66MP0002837_dystrophic_cardiac_calcinosis1.28611480
67MP0004142_abnormal_muscle_tone1.27644077
68MP0000049_abnormal_middle_ear1.24372541
69MP0009780_abnormal_chondrocyte_physiolo1.21803259
70MP0003942_abnormal_urinary_system1.21156415
71MP0004019_abnormal_vitamin_homeostasis1.21006243
72MP0005623_abnormal_meninges_morphology1.20972945
73MP0000647_abnormal_sebaceous_gland1.20775672
74MP0004147_increased_porphyrin_level1.20078105
75MP0002882_abnormal_neuron_morphology1.19705611
76MP0000534_abnormal_ureter_morphology1.19479173
77MP0002733_abnormal_thermal_nociception1.18064643
78MP0005503_abnormal_tendon_morphology1.16983712
79MP0000751_myopathy1.16721512
80MP0003938_abnormal_ear_development1.16080140
81MP0000631_abnormal_neuroendocrine_gland1.16024552
82MP0004811_abnormal_neuron_physiology1.15084908
83MP0004272_abnormal_basement_membrane1.14834920
84MP0001299_abnormal_eye_distance/1.11707509
85MP0005365_abnormal_bile_salt1.11299504
86MP0001970_abnormal_pain_threshold1.11213454
87MP0002938_white_spotting1.09857814
88MP0002138_abnormal_hepatobiliary_system1.09290656
89MP0010678_abnormal_skin_adnexa1.08130329
90MP0009250_abnormal_appendicular_skeleto1.07877246
91MP0003861_abnormal_nervous_system1.07520253
92MP0003890_abnormal_embryonic-extraembry1.07381856
93MP0002152_abnormal_brain_morphology1.06833811
94MP0009053_abnormal_anal_canal1.06516166
95MP0003121_genomic_imprinting1.06382242
96MP0003755_abnormal_palate_morphology1.05311187
97MP0004145_abnormal_muscle_electrophysio1.03944018
98MP0003937_abnormal_limbs/digits/tail_de1.03063940
99MP0003329_amyloid_beta_deposits1.00863519
100MP0005084_abnormal_gallbladder_morpholo1.00822120
101MP0001485_abnormal_pinna_reflex0.99050323
102MP0003137_abnormal_impulse_conducting0.98879746
103MP0004924_abnormal_behavior0.98425979
104MP0005386_behavior/neurological_phenoty0.98425979
105MP0005379_endocrine/exocrine_gland_phen0.98096570
106MP0008872_abnormal_physiological_respon0.96552281
107MP0002066_abnormal_motor_capabilities/c0.96297286
108MP0010329_abnormal_lipoprotein_level0.95327117
109MP0000462_abnormal_digestive_system0.95279640
110MP0005394_taste/olfaction_phenotype0.93731443
111MP0005499_abnormal_olfactory_system0.93731443
112MP0004133_heterotaxia0.93684589
113MP0003123_paternal_imprinting0.92220750
114MP0004233_abnormal_muscle_weight0.91589421
115MP0002233_abnormal_nose_morphology0.89590939
116MP0000762_abnormal_tongue_morphology0.89587666
117MP0002693_abnormal_pancreas_physiology0.89381444
118MP0002249_abnormal_larynx_morphology0.86970381
119MP0002752_abnormal_somatic_nervous0.86962461
120MP0002116_abnormal_craniofacial_bone0.86879415
121MP0010234_abnormal_vibrissa_follicle0.85882628
122MP0000026_abnormal_inner_ear0.85720704
123MP0001756_abnormal_urination0.85374247
124MP0005275_abnormal_skin_tensile0.85035073
125MP0002638_abnormal_pupillary_reflex0.84860514
126MP0008438_abnormal_cutaneous_collagen0.83920225
127MP0000538_abnormal_urinary_bladder0.82848228
128MP0002909_abnormal_adrenal_gland0.82684819
129MP0005645_abnormal_hypothalamus_physiol0.82040068
130MP0001984_abnormal_olfaction0.81485874
131MP0003119_abnormal_digestive_system0.81298404
132MP0008789_abnormal_olfactory_epithelium0.81094165
133MP0005391_vision/eye_phenotype0.80790445
134MP0005195_abnormal_posterior_eye0.80592363
135MP0005187_abnormal_penis_morphology0.80572999
136MP0005332_abnormal_amino_acid0.80412354
137MP0002160_abnormal_reproductive_system0.80101140
138MP0000372_irregular_coat_pigmentation0.80032396
139MP0002177_abnormal_outer_ear0.79298277
140MP0004742_abnormal_vestibular_system0.78872580
141MP0009384_cardiac_valve_regurgitation0.78242367
142MP0000230_abnormal_systemic_arterial0.77904951
143MP0004484_altered_response_of0.77001148
144MP0004085_abnormal_heartbeat0.76948397
145MP0005248_abnormal_Harderian_gland0.74348411

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.69008262
2Focal seizures (HP:0007359)3.87878514
3Nephronophthisis (HP:0000090)3.81980800
4Intestinal atresia (HP:0011100)3.73260804
5Abnormality of midbrain morphology (HP:0002418)3.69581373
6Molar tooth sign on MRI (HP:0002419)3.69581373
7Pancreatic cysts (HP:0001737)3.65315755
8Atonic seizures (HP:0010819)3.55654294
9Abnormality of the renal cortex (HP:0011035)3.51449901
10Pancreatic fibrosis (HP:0100732)3.46921980
11Tubular atrophy (HP:0000092)3.39334122
12Abnormality of the renal medulla (HP:0100957)3.38596378
13Febrile seizures (HP:0002373)3.12766180
14True hermaphroditism (HP:0010459)3.07763683
15Amblyopia (HP:0000646)3.06645745
16Chronic hepatic failure (HP:0100626)3.01143385
17Hypothermia (HP:0002045)2.96646703
18Medial flaring of the eyebrow (HP:0010747)2.94458239
19Broad-based gait (HP:0002136)2.92176542
20Congenital stationary night blindness (HP:0007642)2.91568447
21Exotropia (HP:0000577)2.84497954
22Absence seizures (HP:0002121)2.83674158
23Termporal pattern (HP:0011008)2.75242256
24Insidious onset (HP:0003587)2.75242256
25Polydipsia (HP:0001959)2.74471198
26Abnormal drinking behavior (HP:0030082)2.74471198
27Myokymia (HP:0002411)2.73551185
28Morphological abnormality of the middle ear (HP:0008609)2.67004375
29Epileptic encephalopathy (HP:0200134)2.66253587
30Renal cortical cysts (HP:0000803)2.65686556
31Hyperthyroidism (HP:0000836)2.65607687
32Hyperventilation (HP:0002883)2.65277878
33Polyphagia (HP:0002591)2.64731370
34Dialeptic seizures (HP:0011146)2.56434411
35Drooling (HP:0002307)2.55830907
36Excessive salivation (HP:0003781)2.55830907
37Nuclear cataract (HP:0100018)2.53162829
38Hypoventilation (HP:0002791)2.49202014
39Generalized tonic-clonic seizures (HP:0002069)2.48900926
40Buphthalmos (HP:0000557)2.48495613
41Pendular nystagmus (HP:0012043)2.42912530
42Attenuation of retinal blood vessels (HP:0007843)2.41381212
43Gaze-evoked nystagmus (HP:0000640)2.39912735
44Tubulointerstitial fibrosis (HP:0005576)2.39490341
45Cystic liver disease (HP:0006706)2.37803064
46Progressive cerebellar ataxia (HP:0002073)2.32605542
47Keratoconus (HP:0000563)2.32168141
48Increased corneal curvature (HP:0100692)2.32168141
49Heterochromia iridis (HP:0001100)2.29834436
50Protruding tongue (HP:0010808)2.29427495
51Cerebellar dysplasia (HP:0007033)2.27577800
52Gait imbalance (HP:0002141)2.24626698
53Gastrointestinal atresia (HP:0002589)2.22141621
54Labial hypoplasia (HP:0000066)2.20910870
55Amyotrophic lateral sclerosis (HP:0007354)2.20787482
56Anophthalmia (HP:0000528)2.19915730
57Narrow nasal bridge (HP:0000446)2.19099995
58Abnormal rod and cone electroretinograms (HP:0008323)2.18931005
59Abnormal pancreas size (HP:0012094)2.18857777
60Polyuria (HP:0000103)2.17856504
61Bony spicule pigmentary retinopathy (HP:0007737)2.17617280
62Tubulointerstitial abnormality (HP:0001969)2.17115333
63Bronchomalacia (HP:0002780)2.15076417
64Hydroureter (HP:0000072)2.13355219
65Choroideremia (HP:0001139)2.10518624
66Hemiparesis (HP:0001269)2.09372878
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.09358938
68Fair hair (HP:0002286)2.07955580
69Abnormality of urine glucose concentration (HP:0011016)2.07387157
70Glycosuria (HP:0003076)2.07387157
71Pachygyria (HP:0001302)2.07232084
72Prominent supraorbital ridges (HP:0000336)2.06341004
73Atelectasis (HP:0100750)2.05936540
74Abnormality of the labia minora (HP:0012880)2.05545935
75Congenital, generalized hypertrichosis (HP:0004540)2.05166972
76Congenital primary aphakia (HP:0007707)2.04675418
77Congenital hepatic fibrosis (HP:0002612)2.01952802
78Abnormality of vitamin B metabolism (HP:0004340)2.01932770
79Epidermoid cyst (HP:0200040)2.00914147
80Cerebral inclusion bodies (HP:0100314)2.00784818
81Absent speech (HP:0001344)1.99640960
82Truncus arteriosus (HP:0001660)1.99156067
83Genital tract atresia (HP:0001827)1.98923018
84Congenital sensorineural hearing impairment (HP:0008527)1.97701393
85Furrowed tongue (HP:0000221)1.97522541
86Hypsarrhythmia (HP:0002521)1.97438446
87Hypoplastic female external genitalia (HP:0012815)1.97253942
88Aqueductal stenosis (HP:0002410)1.95812701
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.95283214
90Large for gestational age (HP:0001520)1.94013600
91Abnormal biliary tract physiology (HP:0012439)1.93768725
92Bile duct proliferation (HP:0001408)1.93768725
93Limb dystonia (HP:0002451)1.93736302
94Inability to walk (HP:0002540)1.93651614
95Visual hallucinations (HP:0002367)1.90695150
96Ketoacidosis (HP:0001993)1.90439954
97Aplasia involving bones of the extremities (HP:0009825)1.89787718
98Aplasia involving bones of the upper limbs (HP:0009823)1.89787718
99Aplasia of the phalanges of the hand (HP:0009802)1.89787718
100Atrophic scars (HP:0001075)1.87750370
101Down-sloping shoulders (HP:0200021)1.87124568
102Autism (HP:0000717)1.86336326
103Abnormal biliary tract morphology (HP:0012440)1.86302314
104Postaxial foot polydactyly (HP:0001830)1.86147956
105Hypoplasia of the fovea (HP:0007750)1.86055961
106Aplasia/Hypoplasia of the fovea (HP:0008060)1.86055961
107Abnormality of salivation (HP:0100755)1.85841700
108Abolished electroretinogram (ERG) (HP:0000550)1.85617813
109Abnormal eating behavior (HP:0100738)1.85446629
110Postaxial hand polydactyly (HP:0001162)1.84438890
111Nephrogenic diabetes insipidus (HP:0009806)1.83886649
112Congenital glaucoma (HP:0001087)1.83092933
113Anencephaly (HP:0002323)1.83047477
114Neurofibrillary tangles (HP:0002185)1.82400913
115Agitation (HP:0000713)1.82238842
116Vaginal atresia (HP:0000148)1.81480512
117Chorioretinal atrophy (HP:0000533)1.80153069
118Methylmalonic acidemia (HP:0002912)1.79538462
119Megalencephaly (HP:0001355)1.79344966
120Cutaneous finger syndactyly (HP:0010554)1.79189216
121Proximal tubulopathy (HP:0000114)1.79120326
122Decreased circulating renin level (HP:0003351)1.79059019
123Ulnar claw (HP:0001178)1.78973271
124Concave nail (HP:0001598)1.78777702
125Sclerocornea (HP:0000647)1.78527471
126Abnormality of renal excretion (HP:0011036)1.78331079
127Sporadic (HP:0003745)1.78088314
128Abnormal urine output (HP:0012590)1.77842941
129Impaired vibration sensation in the lower limbs (HP:0002166)1.77609301
130Esotropia (HP:0000565)1.77364722
131Abnormality of the pons (HP:0007361)1.77118371
132Progressive inability to walk (HP:0002505)1.77118060
133Hypoplasia of the pons (HP:0012110)1.76944900
134Shallow orbits (HP:0000586)1.75900335
135Upper limb muscle weakness (HP:0003484)1.75896616
136Wrist flexion contracture (HP:0001239)1.75456752
137Hypoglycemic coma (HP:0001325)1.75422591
138Severe muscular hypotonia (HP:0006829)1.74873593
139Thickened helices (HP:0000391)1.74487072
140Abnormality of macular pigmentation (HP:0008002)1.72817197
141Type II lissencephaly (HP:0007260)1.72463240
142Male pseudohermaphroditism (HP:0000037)1.72095951
143Volvulus (HP:0002580)1.71179675
144Widely spaced teeth (HP:0000687)1.71112797
145Tented upper lip vermilion (HP:0010804)1.70720822
146Optic nerve hypoplasia (HP:0000609)1.70186775
147Blue irides (HP:0000635)1.69913936
148Shoulder girdle muscle weakness (HP:0003547)1.69887746
149Aplasia cutis congenita (HP:0001057)1.69462225
150Fragile nails (HP:0001808)1.69152336
151Neuronal loss in central nervous system (HP:0002529)1.69002207
152Short tibia (HP:0005736)1.68254342
153Aplasia/hypoplasia of the uterus (HP:0008684)1.67955561
154Epileptiform EEG discharges (HP:0011182)1.67219666
155Lissencephaly (HP:0001339)1.67079810
156Abnormality of the labia (HP:0000058)1.66309382
157Spinal cord compression (HP:0002176)1.65732986
158Bilateral microphthalmos (HP:0007633)1.64743280
159Short 4th metacarpal (HP:0010044)1.63898166
160Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63898166
161Venous insufficiency (HP:0005293)1.63110145
162Coronal craniosynostosis (HP:0004440)1.62910009
163Aplasia/Hypoplasia of the brainstem (HP:0007362)1.62149425
164Hypoplasia of the brainstem (HP:0002365)1.62149425
165Oligodactyly (hands) (HP:0001180)1.61887601
166Action tremor (HP:0002345)1.59950480
167Ankyloglossia (HP:0010296)1.59063639
168Supranuclear gaze palsy (HP:0000605)1.58196270
169Preaxial foot polydactyly (HP:0001841)1.57728585
170Zonular cataract (HP:0010920)1.56199704
171Progressive sensorineural hearing impairment (HP:0000408)1.55832221
172Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.55661989
173Truncal ataxia (HP:0002078)1.54995384
174Facial hemangioma (HP:0000329)1.54529654
175Hypoplastic nipples (HP:0002557)1.53788318
176Abnormality of the lower motor neuron (HP:0002366)1.52933259
177Generalized hypopigmentation of hair (HP:0011358)1.52515830
178EEG with generalized epileptiform discharges (HP:0011198)1.52372271
179Anosmia (HP:0000458)1.51675867

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.20390332
2EPHA44.09531279
3MARK13.46451469
4ACVR1B3.00464135
5MAP3K42.99913629
6KSR12.84691579
7MAP3K92.66004986
8EPHB22.58627088
9MAP4K22.58394362
10CASK2.55570522
11UHMK12.38069390
12MAP3K122.35133997
13MAP2K72.27015820
14ADRBK22.20768148
15NTRK22.20392047
16NTRK12.15248827
17MINK12.13893153
18GRK12.12129023
19RIPK42.07357126
20AKT32.06883555
21BCR2.05227576
22SIK32.01684150
23MAPK131.98606631
24OXSR11.94221801
25STK161.85311389
26WNK31.77609062
27MAP2K41.74899176
28PINK11.72649197
29SIK21.70545702
30INSRR1.58585757
31PNCK1.58244951
32LATS21.56137509
33PAK31.51552103
34FGFR21.38379147
35PAK61.33739378
36NUAK11.29265500
37NME11.20782033
38TGFBR11.20285679
39DDR21.19114913
40PLK21.18881783
41MST41.14217679
42ZAK1.13758391
43IRAK21.13048983
44NLK1.12608652
45FER1.12314119
46CAMK2A1.12205673
47CAMK2B1.11332343
48CDK51.10382788
49KSR21.09065490
50MKNK21.08309492
51DYRK21.07470053
52BMPR21.02043154
53GRK51.01746453
54TRIM281.01655107
55TIE10.99322521
56DAPK20.98407357
57ARAF0.95794567
58DMPK0.92415000
59PASK0.91853033
60CAMKK10.91834231
61TNIK0.90902866
62PDGFRA0.89790337
63PTK2B0.88993564
64STK30.87429281
65PRKCE0.86467021
66FRK0.85189243
67FGR0.84284529
68TAOK30.83956831
69TYRO30.82245981
70CDK180.81282747
71BRSK20.80698015
72SGK20.80549009
73MUSK0.79858246
74EPHA30.79431983
75CDK140.78218526
76CAMKK20.78218196
77MAP3K20.77941091
78ADRBK10.75696253
79CSNK1A1L0.74256131
80BMPR1B0.72986802
81TLK10.72299762
82LATS10.72279325
83ERBB30.70572275
84CDK150.68454112
85ERBB40.68113008
86SGK4940.67299066
87SGK2230.67299066
88ROCK20.66499553
89WNK40.65958552
90PRKCG0.65896442
91RET0.65582035
92PIK3CA0.64326671
93PRKCI0.63090433
94MAP2K10.62345002
95MAP2K60.61443277
96ROCK10.60362363
97PTK20.59760277
98GRK70.58144551
99CSNK1G20.57557305
100MAP3K60.57554644
101CDK11A0.56916046
102DAPK10.55783256
103CAMK2D0.55274874
104RAF10.52455470
105PRKCZ0.51343262
106STK390.51320676
107DYRK1A0.51037807
108EIF2AK30.48875503
109NEK60.47483663
110WNK10.46681003
111CSNK1G30.45255800
112MOS0.45205159
113RPS6KA40.45204196
114PRKG10.45005521
115STK110.44462172
116CAMK1G0.44413976
117PRKD30.44143129
118FYN0.43452125
119MKNK10.43233585
120STK380.42087717
121SGK10.40997742
122PRKACA0.40862641
123FGFR10.40838340
124CSNK1A10.39565004
125MARK20.39298749
126ERBB20.39269833
127STK38L0.38720187
128DYRK30.38534143
129CSNK1E0.38012136
130MET0.37971745
131CDC42BPA0.37419503
132PHKG20.37144354
133PHKG10.37144354
134PRKAA10.35698314
135ABL20.34539589
136RPS6KA20.34399059
137PDGFRB0.34388014
138TRPM70.34330657
139IRAK10.33743455
140CSNK1D0.33723368
141CDK80.33344242
142ICK0.32654633
143PAK20.32169668
144CSNK1G10.31174610
145PKN10.31059953
146PIK3CG0.30846493
147MAPK100.30085019
148PRKACB0.29700364
149VRK10.29169041
150STK240.29149229
151PRKCA0.29042347
152CHUK0.28583426

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.88685939
2Nicotine addiction_Homo sapiens_hsa050333.83998269
3Butanoate metabolism_Homo sapiens_hsa006502.71701407
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58353248
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56871215
6Caffeine metabolism_Homo sapiens_hsa002322.37585828
7Long-term potentiation_Homo sapiens_hsa047202.32571029
8Glutamatergic synapse_Homo sapiens_hsa047242.31963988
9Axon guidance_Homo sapiens_hsa043602.29996064
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.29850405
11Linoleic acid metabolism_Homo sapiens_hsa005912.29162599
12Circadian entrainment_Homo sapiens_hsa047132.22904707
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17843013
14Protein export_Homo sapiens_hsa030602.14129411
15GABAergic synapse_Homo sapiens_hsa047272.12140122
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10176027
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08666295
18Dopaminergic synapse_Homo sapiens_hsa047282.04055985
19Serotonergic synapse_Homo sapiens_hsa047262.01073330
20Taste transduction_Homo sapiens_hsa047422.00745463
21Morphine addiction_Homo sapiens_hsa050321.99838735
22Synaptic vesicle cycle_Homo sapiens_hsa047211.95633220
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94757081
24Tryptophan metabolism_Homo sapiens_hsa003801.90733215
25Amphetamine addiction_Homo sapiens_hsa050311.88159637
26Long-term depression_Homo sapiens_hsa047301.80658202
27Renin secretion_Homo sapiens_hsa049241.79464916
28Salivary secretion_Homo sapiens_hsa049701.75473546
29Ether lipid metabolism_Homo sapiens_hsa005651.66632432
30Retinol metabolism_Homo sapiens_hsa008301.66575997
31Gap junction_Homo sapiens_hsa045401.65626110
32Sulfur metabolism_Homo sapiens_hsa009201.64968746
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62976925
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59208918
35Oxytocin signaling pathway_Homo sapiens_hsa049211.58546055
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57120298
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.55857550
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.54731935
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54448607
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.51354843
41Nitrogen metabolism_Homo sapiens_hsa009101.49650305
42Selenocompound metabolism_Homo sapiens_hsa004501.49170962
43GnRH signaling pathway_Homo sapiens_hsa049121.47230504
44Melanogenesis_Homo sapiens_hsa049161.43970043
45Insulin secretion_Homo sapiens_hsa049111.43812168
46Calcium signaling pathway_Homo sapiens_hsa040201.42878222
47Cholinergic synapse_Homo sapiens_hsa047251.41858064
48Cardiac muscle contraction_Homo sapiens_hsa042601.41138475
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.40548243
50Propanoate metabolism_Homo sapiens_hsa006401.39794610
51Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39703212
52Olfactory transduction_Homo sapiens_hsa047401.39635397
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39102622
54Gastric acid secretion_Homo sapiens_hsa049711.39012745
55Dorso-ventral axis formation_Homo sapiens_hsa043201.38599847
56Cocaine addiction_Homo sapiens_hsa050301.37960802
57Chemical carcinogenesis_Homo sapiens_hsa052041.34280982
58Hedgehog signaling pathway_Homo sapiens_hsa043401.34263273
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33279443
60Collecting duct acid secretion_Homo sapiens_hsa049661.31740936
61Oxidative phosphorylation_Homo sapiens_hsa001901.27478228
62ErbB signaling pathway_Homo sapiens_hsa040121.26197337
63Alzheimers disease_Homo sapiens_hsa050101.24135698
64Glioma_Homo sapiens_hsa052141.21943591
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21815070
66Dilated cardiomyopathy_Homo sapiens_hsa054141.19314613
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18690020
68Wnt signaling pathway_Homo sapiens_hsa043101.18608170
69Basal cell carcinoma_Homo sapiens_hsa052171.16472931
70Estrogen signaling pathway_Homo sapiens_hsa049151.13406418
71ABC transporters_Homo sapiens_hsa020101.13312273
72Peroxisome_Homo sapiens_hsa041461.12628581
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12452865
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11755464
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11510257
76Fat digestion and absorption_Homo sapiens_hsa049751.08915753
77Vibrio cholerae infection_Homo sapiens_hsa051101.07848718
78Hippo signaling pathway_Homo sapiens_hsa043901.07241028
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05502105
80ECM-receptor interaction_Homo sapiens_hsa045121.03774725
81Basal transcription factors_Homo sapiens_hsa030221.01382297
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00661092
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00511285
84cAMP signaling pathway_Homo sapiens_hsa040241.00095904
85Fatty acid degradation_Homo sapiens_hsa000710.95787382
86Oocyte meiosis_Homo sapiens_hsa041140.94144075
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94090486
88beta-Alanine metabolism_Homo sapiens_hsa004100.92671693
89Bile secretion_Homo sapiens_hsa049760.92385498
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91516798
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90303579
92Mineral absorption_Homo sapiens_hsa049780.88448032
93Parkinsons disease_Homo sapiens_hsa050120.88328756
94Phototransduction_Homo sapiens_hsa047440.88167227
95Circadian rhythm_Homo sapiens_hsa047100.88120587
96Rap1 signaling pathway_Homo sapiens_hsa040150.87379966
97Histidine metabolism_Homo sapiens_hsa003400.87107414
98Arachidonic acid metabolism_Homo sapiens_hsa005900.86855503
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.86016762
100VEGF signaling pathway_Homo sapiens_hsa043700.83436950
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77736351
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75184585
103Focal adhesion_Homo sapiens_hsa045100.75103725
104Steroid biosynthesis_Homo sapiens_hsa001000.74609935
105Renal cell carcinoma_Homo sapiens_hsa052110.74511520
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74463785
107Regulation of autophagy_Homo sapiens_hsa041400.74085274
108Fatty acid metabolism_Homo sapiens_hsa012120.74066787
109MAPK signaling pathway_Homo sapiens_hsa040100.73987512
110Ras signaling pathway_Homo sapiens_hsa040140.73950451
111Type II diabetes mellitus_Homo sapiens_hsa049300.73785681
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71714050
113Huntingtons disease_Homo sapiens_hsa050160.69706334
114Adherens junction_Homo sapiens_hsa045200.69475090
115Sphingolipid metabolism_Homo sapiens_hsa006000.68628233
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66540674
117Tight junction_Homo sapiens_hsa045300.65485233
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65220551
119Fatty acid biosynthesis_Homo sapiens_hsa000610.65031262
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64605978
121Choline metabolism in cancer_Homo sapiens_hsa052310.63033451
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.62157845
123Proteoglycans in cancer_Homo sapiens_hsa052050.60974057
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60884339
125RNA polymerase_Homo sapiens_hsa030200.59829578
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57458366
127Melanoma_Homo sapiens_hsa052180.57334815
128Pancreatic secretion_Homo sapiens_hsa049720.57242349
129Starch and sucrose metabolism_Homo sapiens_hsa005000.57194743
130Glycerolipid metabolism_Homo sapiens_hsa005610.57066961
131Bladder cancer_Homo sapiens_hsa052190.57048724
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.56562520
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.56046920
134Folate biosynthesis_Homo sapiens_hsa007900.55976783
135TGF-beta signaling pathway_Homo sapiens_hsa043500.55937764
136Amoebiasis_Homo sapiens_hsa051460.55368215
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54828036
138RNA degradation_Homo sapiens_hsa030180.54381356
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.53794383
140Metabolic pathways_Homo sapiens_hsa011000.53768818
141African trypanosomiasis_Homo sapiens_hsa051430.53558776
142Thyroid hormone synthesis_Homo sapiens_hsa049180.52399971
143Cyanoamino acid metabolism_Homo sapiens_hsa004600.52195855
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.51415509
145Protein digestion and absorption_Homo sapiens_hsa049740.50788814
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50044002
147Colorectal cancer_Homo sapiens_hsa052100.49005776
148Phagosome_Homo sapiens_hsa041450.48641560
149Endometrial cancer_Homo sapiens_hsa052130.48629912
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47801315
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47298533
152Vitamin digestion and absorption_Homo sapiens_hsa049770.47004927
153Vitamin B6 metabolism_Homo sapiens_hsa007500.46441170
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45346729
155MicroRNAs in cancer_Homo sapiens_hsa052060.45192027
156AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44344334
157Ovarian steroidogenesis_Homo sapiens_hsa049130.43426062
158Alcoholism_Homo sapiens_hsa050340.43245853
159Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42443302
160One carbon pool by folate_Homo sapiens_hsa006700.41765634
161Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41341931
162Pathways in cancer_Homo sapiens_hsa052000.40014085
163Glucagon signaling pathway_Homo sapiens_hsa049220.39752232
164Rheumatoid arthritis_Homo sapiens_hsa053230.39385416

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