SAMD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.13324724
2central nervous system myelination (GO:0022010)6.13324724
3fatty acid elongation (GO:0030497)4.60539453
4negative regulation of neurotransmitter transport (GO:0051589)4.12220542
5negative regulation of neurotransmitter secretion (GO:0046929)4.04335061
6long-chain fatty acid biosynthetic process (GO:0042759)4.00355347
7presynaptic membrane assembly (GO:0097105)3.90062978
8presynaptic membrane organization (GO:0097090)3.81583780
9neuron cell-cell adhesion (GO:0007158)3.77965062
10myelination (GO:0042552)3.60612157
11axon ensheathment (GO:0008366)3.58850375
12ensheathment of neurons (GO:0007272)3.58850375
13establishment of mitochondrion localization (GO:0051654)3.43640178
14neuronal action potential propagation (GO:0019227)3.43399633
15regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.40228333
16negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38591359
17L-amino acid import (GO:0043092)3.23693740
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.22012970
19protein localization to synapse (GO:0035418)3.21529545
20photoreceptor cell differentiation (GO:0046530)3.20810106
21eye photoreceptor cell differentiation (GO:0001754)3.20810106
22cerebral cortex radially oriented cell migration (GO:0021799)3.18977906
23regulation of short-term neuronal synaptic plasticity (GO:0048172)3.15984102
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.15611310
25regulation of Rac protein signal transduction (GO:0035020)3.12446519
26establishment of protein localization to Golgi (GO:0072600)3.11673116
27righting reflex (GO:0060013)3.11172027
28regulation of synaptic vesicle exocytosis (GO:2000300)3.09390018
29neuron recognition (GO:0008038)3.04732561
30protein targeting to Golgi (GO:0000042)3.04709436
31glutamate secretion (GO:0014047)3.04679990
32synaptic vesicle maturation (GO:0016188)3.04450052
33synaptic vesicle exocytosis (GO:0016079)3.03852974
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.03072444
35negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.01960135
36glycosphingolipid biosynthetic process (GO:0006688)3.01010047
37cholesterol biosynthetic process (GO:0006695)3.00157857
38regulation of cell communication by electrical coupling (GO:0010649)2.99990115
39vocalization behavior (GO:0071625)2.99841188
40response to methylmercury (GO:0051597)2.99721086
41positive regulation of protein autophosphorylation (GO:0031954)2.97352244
42negative regulation of protein localization to cell surface (GO:2000009)2.97085452
43platelet dense granule organization (GO:0060155)2.95800180
44dendritic spine morphogenesis (GO:0060997)2.95645822
45negative regulation of dendrite development (GO:2000171)2.94153914
46neural tube formation (GO:0001841)2.93418761
47atrial cardiac muscle cell action potential (GO:0086014)2.88436652
48glutamate receptor signaling pathway (GO:0007215)2.88072234
49glycerophospholipid catabolic process (GO:0046475)2.86553159
50regulation of protein glycosylation (GO:0060049)2.86496177
51apical protein localization (GO:0045176)2.85719736
52pyrimidine nucleobase catabolic process (GO:0006208)2.84471372
53positive regulation of meiosis (GO:0045836)2.83868523
54inositol phosphate catabolic process (GO:0071545)2.83637140
55neurotransmitter-gated ion channel clustering (GO:0072578)2.83287333
56response to pheromone (GO:0019236)2.80226626
57protein localization to cilium (GO:0061512)2.77283137
58positive regulation of muscle hypertrophy (GO:0014742)2.74651983
59positive regulation of cardiac muscle hypertrophy (GO:0010613)2.74651983
60retrograde transport, vesicle recycling within Golgi (GO:0000301)2.74376530
61postsynaptic membrane organization (GO:0001941)2.73304305
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.71917749
63regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.71529758
64dendrite morphogenesis (GO:0048813)2.69863315
65sterol biosynthetic process (GO:0016126)2.69621315
66regulation of neuronal synaptic plasticity (GO:0048168)2.69278313
67positive regulation of meiotic cell cycle (GO:0051446)2.68990977
68axonal fasciculation (GO:0007413)2.68201499
69neuron-neuron synaptic transmission (GO:0007270)2.67570063
70gamma-aminobutyric acid signaling pathway (GO:0007214)2.67552086
71negative regulation of cytosolic calcium ion concentration (GO:0051481)2.67377700
72transmission of nerve impulse (GO:0019226)2.67212915
73gamma-aminobutyric acid transport (GO:0015812)2.66782246
74synaptic transmission, glutamatergic (GO:0035249)2.66256097
75detection of calcium ion (GO:0005513)2.66219549
76cerebellar granule cell differentiation (GO:0021707)2.65857311
77negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.65011803
78regulation of long-term neuronal synaptic plasticity (GO:0048169)2.63990514
79neuron remodeling (GO:0016322)2.62799913
80adult walking behavior (GO:0007628)2.61533071
81regulation of hexokinase activity (GO:1903299)2.60065483
82regulation of glucokinase activity (GO:0033131)2.60065483
83positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59049793
84retinal cone cell development (GO:0046549)2.58402461
85regulation of glutamate receptor signaling pathway (GO:1900449)2.58366550
86L-serine transport (GO:0015825)2.55410650
87regulation of synaptic vesicle transport (GO:1902803)2.55281808
88establishment of nucleus localization (GO:0040023)2.54802409
89nucleobase catabolic process (GO:0046113)2.52821147
90import into cell (GO:0098657)2.51503586
91kidney morphogenesis (GO:0060993)2.50639510
92regulation of excitatory postsynaptic membrane potential (GO:0060079)2.49825850
93negative regulation of dendrite morphogenesis (GO:0050774)2.49822526
94regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.49749214
95keratinocyte development (GO:0003334)2.49705365
96dendrite development (GO:0016358)2.49308016
97peptidyl-cysteine modification (GO:0018198)2.48344154
98protein prenylation (GO:0018342)2.48239023
99prenylation (GO:0097354)2.48239023
100nerve growth factor signaling pathway (GO:0038180)2.47781219
101isoprenoid biosynthetic process (GO:0008299)2.47681239
102locomotory exploration behavior (GO:0035641)2.46997522
103C4-dicarboxylate transport (GO:0015740)2.46682127
104intra-Golgi vesicle-mediated transport (GO:0006891)2.46670998
105regulation of collateral sprouting (GO:0048670)2.46594510
106myelin maintenance (GO:0043217)2.46268986
107regulation of dendritic spine morphogenesis (GO:0061001)2.45728227
108amino acid import (GO:0043090)2.45580716
109oligodendrocyte differentiation (GO:0048709)2.44898872
110proline transport (GO:0015824)2.44896698
111asymmetric protein localization (GO:0008105)2.44047506
112protein localization to Golgi apparatus (GO:0034067)2.41958598
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.41945532
114Golgi to endosome transport (GO:0006895)2.41503164
115negative regulation of synaptic transmission (GO:0050805)2.41341950
116regulation of voltage-gated calcium channel activity (GO:1901385)2.41017776
117retinal ganglion cell axon guidance (GO:0031290)2.40375116
118negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.40279028
119regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.39920931
120long-term synaptic potentiation (GO:0060291)2.39704844
121inner ear receptor stereocilium organization (GO:0060122)2.38079726
122Rap protein signal transduction (GO:0032486)2.37357522
123regulation of synaptic transmission, GABAergic (GO:0032228)2.37156094
124positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.36645105
125membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.36558366
126protein K11-linked deubiquitination (GO:0035871)2.35491410
127limb bud formation (GO:0060174)2.35326239
128astrocyte development (GO:0014002)2.34948524
129phosphorylated carbohydrate dephosphorylation (GO:0046838)2.34882536
130inositol phosphate dephosphorylation (GO:0046855)2.34882536
131olfactory bulb development (GO:0021772)2.34580331
132long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.34392990
133regulation of neurotransmitter secretion (GO:0046928)2.34156915
134regulation of postsynaptic membrane potential (GO:0060078)2.33618038
135membrane assembly (GO:0071709)2.33390781
136regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33369189
137startle response (GO:0001964)2.33165857
138negative regulation of axon extension (GO:0030517)2.32758240
139positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.32019540
140regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.31688626
141regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.31428139
142long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.30957454
143intraciliary transport (GO:0042073)2.30873095
144mechanosensory behavior (GO:0007638)2.30730801
145magnesium ion transport (GO:0015693)2.30695048
146positive regulation of synapse assembly (GO:0051965)2.30636266
147response to lipoprotein particle (GO:0055094)2.30610266
148central nervous system projection neuron axonogenesis (GO:0021952)2.29671832
149regulation of calcium ion-dependent exocytosis (GO:0017158)2.29575671
150regulation of relaxation of muscle (GO:1901077)2.29516138
151polyol catabolic process (GO:0046174)2.28967282
152negative regulation of axonogenesis (GO:0050771)2.28733577
153prostate gland growth (GO:0060736)2.28276941
154insulin secretion (GO:0030073)2.28135597
155central nervous system neuron axonogenesis (GO:0021955)2.26438851
156positive regulation of oligodendrocyte differentiation (GO:0048714)2.26364783
157positive regulation of glycoprotein biosynthetic process (GO:0010560)2.25854327
158G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.25289469
159regulation of glutamate secretion (GO:0014048)2.25123154
160auditory behavior (GO:0031223)2.24660492
161negative regulation of hormone biosynthetic process (GO:0032353)2.24637666
162regulation of dendritic spine development (GO:0060998)2.24629887
163myelination in peripheral nervous system (GO:0022011)2.23938199
164peripheral nervous system axon ensheathment (GO:0032292)2.23938199
165regulation of protein autophosphorylation (GO:0031952)2.23851173
166positive regulation of membrane potential (GO:0045838)2.23388773
167cilium morphogenesis (GO:0060271)2.23383393
168parental behavior (GO:0060746)2.23048135
169cyclic nucleotide catabolic process (GO:0009214)2.21567370
170regulation of neurotransmitter uptake (GO:0051580)2.20659073
171glial cell proliferation (GO:0014009)2.20452382
172positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.19646087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.76178033
2* GBX2_23144817_ChIP-Seq_PC3_Human3.56433496
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.45933280
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37624873
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28116647
6TAF15_26573619_Chip-Seq_HEK293_Human2.23430689
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21093635
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10248155
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00469442
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99553824
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99434902
12RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97549503
13EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97549503
14SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94938462
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93425841
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91481318
17MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91160356
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.89251846
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86851982
20EWS_26573619_Chip-Seq_HEK293_Human1.86699486
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.83529268
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80834368
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79902215
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79049281
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76828095
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.74695446
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74026547
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72494483
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72039767
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68833110
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67917871
32BCAT_22108803_ChIP-Seq_LS180_Human1.66470845
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64194648
34P300_19829295_ChIP-Seq_ESCs_Human1.64135489
35AR_21572438_ChIP-Seq_LNCaP_Human1.63559481
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.63484604
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62921769
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61956182
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.61640764
40REST_21632747_ChIP-Seq_MESCs_Mouse1.59819506
41ER_23166858_ChIP-Seq_MCF-7_Human1.58061728
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.54763900
43SMAD4_21799915_ChIP-Seq_A2780_Human1.53784873
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.53215304
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.49691069
46DROSHA_22980978_ChIP-Seq_HELA_Human1.48527561
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47680653
48VDR_22108803_ChIP-Seq_LS180_Human1.46181715
49* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43293439
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43050281
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40576859
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38813952
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37977274
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34348176
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33951899
56CBP_20019798_ChIP-Seq_JUKART_Human1.31071901
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31071901
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30456124
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30300094
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29737323
61* STAT3_23295773_ChIP-Seq_U87_Human1.29563415
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29519695
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28603059
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28341257
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28341257
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27565758
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26603789
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.25884515
69TCF4_22108803_ChIP-Seq_LS180_Human1.25394285
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24813383
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24609472
72SMAD3_21741376_ChIP-Seq_HESCs_Human1.24539474
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.24495248
74RARB_27405468_Chip-Seq_BRAIN_Mouse1.24430467
75IGF1R_20145208_ChIP-Seq_DFB_Human1.23561393
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.22773162
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.21205981
78FUS_26573619_Chip-Seq_HEK293_Human1.20952212
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20362298
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20362298
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20095204
82AR_25329375_ChIP-Seq_VCAP_Human1.18576885
83FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18062108
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17413076
85* EP300_21415370_ChIP-Seq_HL-1_Mouse1.16788814
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.16539077
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16079852
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.15912860
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.15797795
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15723160
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.15372945
92TCF4_23295773_ChIP-Seq_U87_Human1.14284638
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14198826
94CDX2_22108803_ChIP-Seq_LS180_Human1.13526281
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13301026
96RNF2_27304074_Chip-Seq_NSC_Mouse1.13166433
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12149607
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.11958858
99RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11844061
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11641314
101AHR_22903824_ChIP-Seq_MCF-7_Human1.10874388
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10742712
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10411552
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10191865
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.10065335
106TP53_18474530_ChIP-ChIP_U2OS_Human1.09393612
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08982749
108TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08684307
109P53_22387025_ChIP-Seq_ESCs_Mouse1.07935239
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07524914
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.07406996
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07284429
113CJUN_26792858_Chip-Seq_BT549_Human1.06621749
114FLI1_27457419_Chip-Seq_LIVER_Mouse1.05517334
115KDM2B_26808549_Chip-Seq_REH_Human1.05397595
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04734994
117RUNX2_22187159_ChIP-Seq_PCA_Human1.03961566
118P300_18555785_Chip-Seq_ESCs_Mouse1.03375873
119CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02833826
120PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02200428
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00533858
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99387441
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99343009
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.97852384
125TAL1_26923725_Chip-Seq_HPCs_Mouse0.97003360
126SOX2_18555785_Chip-Seq_ESCs_Mouse0.96060759
127STAT3_18555785_Chip-Seq_ESCs_Mouse0.95315796
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93694793
129ZNF274_21170338_ChIP-Seq_K562_Hela0.93520413
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.93459626
131TP53_16413492_ChIP-PET_HCT116_Human0.93365502
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93343339
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93036419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.27279222
2MP0004270_analgesia4.17447097
3MP0004859_abnormal_synaptic_plasticity3.94969639
4MP0000920_abnormal_myelination3.31612221
5MP0003787_abnormal_imprinting3.18973991
6MP0003635_abnormal_synaptic_transmissio2.86598774
7MP0006054_spinal_hemorrhage2.83733280
8MP0002064_seizures2.61358711
9MP0001486_abnormal_startle_reflex2.59603131
10MP0002102_abnormal_ear_morphology2.58865636
11MP0009046_muscle_twitch2.53476667
12MP0009745_abnormal_behavioral_response2.49664746
13MP0002063_abnormal_learning/memory/cond2.46226000
14MP0002272_abnormal_nervous_system2.43409158
15MP0002734_abnormal_mechanical_nocicepti2.38446839
16MP0000778_abnormal_nervous_system2.37047092
17MP0003690_abnormal_glial_cell2.33933411
18MP0005423_abnormal_somatic_nervous2.33554269
19MP0003122_maternal_imprinting2.21014666
20MP0003329_amyloid_beta_deposits2.19082474
21MP0002572_abnormal_emotion/affect_behav2.16017675
22MP0001968_abnormal_touch/_nociception2.13577899
23MP0004742_abnormal_vestibular_system2.11364523
24MP0008877_abnormal_DNA_methylation2.09983008
25MP0003950_abnormal_plasma_membrane2.01750324
26MP0004885_abnormal_endolymph1.99119611
27MP0005551_abnormal_eye_electrophysiolog1.90526266
28MP0005171_absent_coat_pigmentation1.89115808
29MP0003634_abnormal_glial_cell1.85288085
30MP0000516_abnormal_urinary_system1.84009058
31MP0005367_renal/urinary_system_phenotyp1.84009058
32MP0001440_abnormal_grooming_behavior1.82679206
33MP0002837_dystrophic_cardiac_calcinosis1.82367015
34MP0003121_genomic_imprinting1.81577111
35MP0002067_abnormal_sensory_capabilities1.80523880
36MP0000427_abnormal_hair_cycle1.70209098
37MP0001905_abnormal_dopamine_level1.69407074
38MP0002736_abnormal_nociception_after1.67832526
39MP0002735_abnormal_chemical_nociception1.67493398
40MP0004142_abnormal_muscle_tone1.65309973
41MP0002229_neurodegeneration1.63326489
42MP0002254_reproductive_system_inflammat1.54748804
43MP0001529_abnormal_vocalization1.52469256
44MP0005174_abnormal_tail_pigmentation1.52032193
45MP0004924_abnormal_behavior1.51454374
46MP0005386_behavior/neurological_phenoty1.51454374
47MP0001970_abnormal_pain_threshold1.49871839
48MP0003633_abnormal_nervous_system1.46645251
49MP0009780_abnormal_chondrocyte_physiolo1.45989326
50MP0002882_abnormal_neuron_morphology1.44850469
51MP0000955_abnormal_spinal_cord1.44418881
52MP0002909_abnormal_adrenal_gland1.43277898
53MP0003632_abnormal_nervous_system1.42894478
54MP0003631_nervous_system_phenotype1.42732312
55MP0002733_abnormal_thermal_nociception1.42721617
56MP0003136_yellow_coat_color1.42707469
57MP0003890_abnormal_embryonic-extraembry1.42226433
58MP0004215_abnormal_myocardial_fiber1.41801334
59MP0000604_amyloidosis1.41745716
60MP0008569_lethality_at_weaning1.40943654
61MP0005646_abnormal_pituitary_gland1.39756362
62MP0005379_endocrine/exocrine_gland_phen1.39554506
63MP0005410_abnormal_fertilization1.38241778
64MP0004484_altered_response_of1.37264176
65MP0006276_abnormal_autonomic_nervous1.35274988
66MP0001188_hyperpigmentation1.33008395
67MP0002184_abnormal_innervation1.31705698
68MP0003283_abnormal_digestive_organ1.31242363
69MP0002066_abnormal_motor_capabilities/c1.31082511
70MP0004145_abnormal_muscle_electrophysio1.29455842
71MP0001984_abnormal_olfaction1.29190120
72MP0005409_darkened_coat_color1.28727575
73MP0002557_abnormal_social/conspecific_i1.27230732
74MP0001501_abnormal_sleep_pattern1.24675502
75MP0005248_abnormal_Harderian_gland1.21078698
76MP0002234_abnormal_pharynx_morphology1.19986588
77MP0005187_abnormal_penis_morphology1.19810546
78MP0001502_abnormal_circadian_rhythm1.18087126
79MP0001485_abnormal_pinna_reflex1.17375410
80MP0001963_abnormal_hearing_physiology1.15535704
81MP0004811_abnormal_neuron_physiology1.12419957
82MP0004134_abnormal_chest_morphology1.12380315
83MP0005645_abnormal_hypothalamus_physiol1.11501728
84MP0002752_abnormal_somatic_nervous1.06068399
85MP0002822_catalepsy1.05947009
86MP0002090_abnormal_vision1.05848307
87MP0003195_calcinosis1.02377765
88MP0010234_abnormal_vibrissa_follicle1.00467784
89MP0002751_abnormal_autonomic_nervous0.99363144
90MP0010678_abnormal_skin_adnexa0.98822074
91MP0004858_abnormal_nervous_system0.97695287
92MP0005253_abnormal_eye_physiology0.97043329
93MP0005167_abnormal_blood-brain_barrier0.96866790
94MP0002876_abnormal_thyroid_physiology0.96762339
95MP0005195_abnormal_posterior_eye0.95788330
96MP0001177_atelectasis0.95077280
97MP0002152_abnormal_brain_morphology0.94666803
98MP0001986_abnormal_taste_sensitivity0.94628090
99MP0001299_abnormal_eye_distance/0.94452037
100MP0004043_abnormal_pH_regulation0.93680150
101MP0003646_muscle_fatigue0.90288348
102MP0005623_abnormal_meninges_morphology0.87360720
103MP0008260_abnormal_autophagy0.87354248
104MP0004085_abnormal_heartbeat0.84245860
105MP0003137_abnormal_impulse_conducting0.83849565
106MP0000026_abnormal_inner_ear0.83848211
107MP0010386_abnormal_urinary_bladder0.83388020
108MP0000015_abnormal_ear_pigmentation0.82819390
109MP0002928_abnormal_bile_duct0.82349012
110MP0008872_abnormal_physiological_respon0.81904981
111MP0003755_abnormal_palate_morphology0.81887555
112MP0003879_abnormal_hair_cell0.81802884
113MP0000631_abnormal_neuroendocrine_gland0.81244906
114MP0000013_abnormal_adipose_tissue0.79761145
115MP0003045_fibrosis0.78702838
116MP0002168_other_aberrant_phenotype0.75666319
117MP0000383_abnormal_hair_follicle0.75594639
118MP0002163_abnormal_gland_morphology0.75159662
119MP0001944_abnormal_pancreas_morphology0.74980032
120MP0003119_abnormal_digestive_system0.74546379
121MP0000538_abnormal_urinary_bladder0.73540299
122MP0000372_irregular_coat_pigmentation0.72868878
123MP0002332_abnormal_exercise_endurance0.71391531
124MP0000749_muscle_degeneration0.70595479
125MP0003011_delayed_dark_adaptation0.70057229
126MP0000569_abnormal_digit_pigmentation0.68561998
127MP0002069_abnormal_eating/drinking_beha0.63707331
128MP0006072_abnormal_retinal_apoptosis0.62322915
129MP0008874_decreased_physiological_sensi0.61637329
130MP0000747_muscle_weakness0.61625262
131MP0005535_abnormal_body_temperature0.60534464
132MP0005058_abnormal_lysosome_morphology0.60478614
133MP0002638_abnormal_pupillary_reflex0.58497023
134MP0001324_abnormal_eye_pigmentation0.56781578
135MP0001664_abnormal_digestion0.56530880
136MP0001346_abnormal_lacrimal_gland0.55828059
137MP0003938_abnormal_ear_development0.55037407
138MP0000647_abnormal_sebaceous_gland0.53621390
139MP0005451_abnormal_body_composition0.52434278
140MP0002295_abnormal_pulmonary_circulatio0.52386456
141MP0001943_abnormal_respiration0.52065839

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.32355799
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.80274172
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.80274172
4Focal motor seizures (HP:0011153)4.41419390
5Abnormality of the corticospinal tract (HP:0002492)4.30674242
6Cerebral inclusion bodies (HP:0100314)4.05927446
7Insidious onset (HP:0003587)4.02627704
8Termporal pattern (HP:0011008)4.02627704
9Supranuclear gaze palsy (HP:0000605)3.92814281
10Intestinal atresia (HP:0011100)3.91516034
11Epileptic encephalopathy (HP:0200134)3.69789291
12Myokymia (HP:0002411)3.66358361
13Neoplasm of the adrenal cortex (HP:0100641)3.27549108
14Hyperventilation (HP:0002883)3.17284599
15Focal seizures (HP:0007359)3.16852214
16Akinesia (HP:0002304)3.08437578
17Volvulus (HP:0002580)3.06683240
18Aqueductal stenosis (HP:0002410)3.05206031
19Parakeratosis (HP:0001036)3.04261927
20Scanning speech (HP:0002168)3.00892470
21Ankle clonus (HP:0011448)3.00693592
22Spastic gait (HP:0002064)2.96558953
23Action tremor (HP:0002345)2.94905671
24Dysmetria (HP:0001310)2.92854649
25Progressive cerebellar ataxia (HP:0002073)2.90279646
26Pheochromocytoma (HP:0002666)2.84676508
27Onion bulb formation (HP:0003383)2.83541143
28Pancreatic cysts (HP:0001737)2.82607069
29Febrile seizures (HP:0002373)2.80136849
30Peripheral hypomyelination (HP:0007182)2.74550546
31Lower limb muscle weakness (HP:0007340)2.72504763
32Urinary bladder sphincter dysfunction (HP:0002839)2.66400000
33Atonic seizures (HP:0010819)2.64868406
34Intention tremor (HP:0002080)2.62639091
35Retinal dysplasia (HP:0007973)2.62450630
36Broad-based gait (HP:0002136)2.61747716
37Pancreatic fibrosis (HP:0100732)2.54752576
38Large for gestational age (HP:0001520)2.54373753
39Sensory axonal neuropathy (HP:0003390)2.50272277
40Neuroendocrine neoplasm (HP:0100634)2.48771774
41Dialeptic seizures (HP:0011146)2.47379474
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.47058136
43Clumsiness (HP:0002312)2.46046850
44Gaze-evoked nystagmus (HP:0000640)2.38012679
45Drooling (HP:0002307)2.36889287
46Excessive salivation (HP:0003781)2.36889287
47Fetal akinesia sequence (HP:0001989)2.36524576
48Abnormality of the renal cortex (HP:0011035)2.35888084
49Blue irides (HP:0000635)2.34823632
50Generalized tonic-clonic seizures (HP:0002069)2.34134198
51Thickened helices (HP:0000391)2.33732452
52Absence seizures (HP:0002121)2.33237941
53Gait imbalance (HP:0002141)2.32155182
54Postural tremor (HP:0002174)2.31858425
55Segmental peripheral demyelination/remyelination (HP:0003481)2.26256443
56Hyperinsulinemic hypoglycemia (HP:0000825)2.24630586
57Dysdiadochokinesis (HP:0002075)2.23235450
58Mutism (HP:0002300)2.23174740
59Limb dystonia (HP:0002451)2.23066090
60Abnormal pancreas size (HP:0012094)2.22266865
61Generalized myoclonic seizures (HP:0002123)2.21440877
62True hermaphroditism (HP:0010459)2.20357147
63Papillary thyroid carcinoma (HP:0002895)2.18667656
64Urinary urgency (HP:0000012)2.17408600
65Absent speech (HP:0001344)2.15675449
66Nephronophthisis (HP:0000090)2.15249143
67Ketoacidosis (HP:0001993)2.15001459
68Absent/shortened dynein arms (HP:0200106)2.14839107
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.14839107
70Ulnar claw (HP:0001178)2.13690693
71Truncal ataxia (HP:0002078)2.13200139
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.11975131
73Progressive inability to walk (HP:0002505)2.10749596
74Nephrogenic diabetes insipidus (HP:0009806)2.09015599
75Hypothermia (HP:0002045)2.08628828
76Abnormality of midbrain morphology (HP:0002418)2.08047149
77Molar tooth sign on MRI (HP:0002419)2.08047149
78Visual hallucinations (HP:0002367)2.07120800
79Medial flaring of the eyebrow (HP:0010747)2.06857790
80Slow saccadic eye movements (HP:0000514)2.05720928
81Epileptiform EEG discharges (HP:0011182)2.03717007
82Hypoglycemic seizures (HP:0002173)2.03687830
83Gastrointestinal atresia (HP:0002589)2.02145306
84Increased CSF protein (HP:0002922)1.99048520
85Abnormality of the renal medulla (HP:0100957)1.98943341
86Delayed gross motor development (HP:0002194)1.98796201
87Pancreatic islet-cell hyperplasia (HP:0004510)1.98638950
88Generalized hypopigmentation of hair (HP:0011358)1.98023490
89EEG with generalized epileptiform discharges (HP:0011198)1.97872720
90Spastic tetraparesis (HP:0001285)1.96099287
91Decreased motor nerve conduction velocity (HP:0003431)1.95656843
92Autoamputation (HP:0001218)1.95225635
93Abnormal auditory evoked potentials (HP:0006958)1.94756035
94Polydipsia (HP:0001959)1.94428342
95Abnormal drinking behavior (HP:0030082)1.94428342
96Tubular atrophy (HP:0000092)1.93266218
97Abnormal eating behavior (HP:0100738)1.93189040
98Specific learning disability (HP:0001328)1.93113636
99Curly hair (HP:0002212)1.92588271
100Relative macrocephaly (HP:0004482)1.92507465
101Neoplasm of the adrenal gland (HP:0100631)1.92139629
102Megalencephaly (HP:0001355)1.91295179
103Morphological abnormality of the pyramidal tract (HP:0002062)1.90587228
104Impaired vibration sensation in the lower limbs (HP:0002166)1.89605317
105Neuronal loss in central nervous system (HP:0002529)1.89133169
106Astrocytoma (HP:0009592)1.88177987
107Abnormality of the astrocytes (HP:0100707)1.88177987
108Absent septum pellucidum (HP:0001331)1.87277087
109Hypsarrhythmia (HP:0002521)1.86730104
110Poor eye contact (HP:0000817)1.86548522
111Congenital primary aphakia (HP:0007707)1.85210356
112Lissencephaly (HP:0001339)1.85109482
113Hepatoblastoma (HP:0002884)1.84973543
114Hypoglycemic coma (HP:0001325)1.84950881
115Fair hair (HP:0002286)1.84768508
116Type II lissencephaly (HP:0007260)1.84117634
117Widely spaced teeth (HP:0000687)1.84011602
118Congenital malformation of the right heart (HP:0011723)1.83706538
119Double outlet right ventricle (HP:0001719)1.83706538
120Vaginal atresia (HP:0000148)1.83675633
121Hemiparesis (HP:0001269)1.83258431
122Pachygyria (HP:0001302)1.82376504
123Renal cortical cysts (HP:0000803)1.81996634
124Nonprogressive disorder (HP:0003680)1.81855568
125Diplopia (HP:0000651)1.81635526
126Abnormality of binocular vision (HP:0011514)1.81635526
127Epidermoid cyst (HP:0200040)1.81255861
128Genital tract atresia (HP:0001827)1.80505152
129Aplasia involving bones of the upper limbs (HP:0009823)1.79822950
130Aplasia of the phalanges of the hand (HP:0009802)1.79822950
131Aplasia involving bones of the extremities (HP:0009825)1.79822950
132Thyroid carcinoma (HP:0002890)1.79767288
133Optic nerve hypoplasia (HP:0000609)1.79658675
134Steppage gait (HP:0003376)1.79588259
135Genetic anticipation (HP:0003743)1.79352393
136Axonal loss (HP:0003447)1.78786991
137Amblyopia (HP:0000646)1.78129187
138Calf muscle hypertrophy (HP:0008981)1.77416531
139Abnormality of salivation (HP:0100755)1.77339607
140Dyschromatopsia (HP:0007641)1.76313728
141Tongue fasciculations (HP:0001308)1.76221524
142Inappropriate behavior (HP:0000719)1.75841962
143Choroideremia (HP:0001139)1.75506982
144Disproportionate short-trunk short stature (HP:0003521)1.75402389
145Polyphagia (HP:0002591)1.75191394
146Paraplegia (HP:0010550)1.75128455
147Postaxial hand polydactyly (HP:0001162)1.74778415
148Gowers sign (HP:0003391)1.73323602
149Hamartoma of the eye (HP:0010568)1.73059408
150Inability to walk (HP:0002540)1.73054907
151Spastic paraplegia (HP:0001258)1.72736569
152Pulmonic stenosis (HP:0001642)1.72336251
153Thin upper lip vermilion (HP:0000219)1.69481424
154Protruding tongue (HP:0010808)1.69400841
155Cerebellar dysplasia (HP:0007033)1.69263176
156Furrowed tongue (HP:0000221)1.68677257
157Thyroiditis (HP:0100646)1.68536424
158Exotropia (HP:0000577)1.66914931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.68482970
2MARK13.44367765
3CASK3.39061797
4STK393.26374407
5PRPF4B3.16119422
6ACVR1B2.83567760
7OXSR12.76786019
8EPHA42.56558597
9PBK2.39127065
10TRIM282.11265210
11BCR2.10829973
12MUSK1.98609242
13MAP2K71.93545276
14MKNK21.89440685
15NTRK31.87452765
16STK38L1.79834085
17PKN11.69250218
18EPHB11.62625218
19MAPKAPK51.61721278
20EIF2AK31.60501221
21MAP4K21.59425706
22MAP3K41.56805239
23NTRK11.56474471
24DAPK21.52389149
25SGK2231.52300272
26SGK4941.52300272
27PLK21.51130439
28FER1.49833197
29MAPK131.47572445
30PNCK1.47463467
31NTRK21.45507871
32MINK11.41191305
33BMPR21.37716167
34MAP3K91.35843198
35TNIK1.34346492
36MST41.34122057
37CDK191.32776345
38NEK61.30371970
39RIPK41.28678430
40WNK41.27686724
41GRK11.26143391
42PAK61.24666415
43FGFR21.22845464
44UHMK11.21667378
45DYRK21.21645704
46CSNK1G21.19734002
47CDK51.18252343
48BRD41.15447563
49CAMK2B1.10127404
50CAMK2A1.09811407
51MAP3K121.06229378
52CSNK1A1L1.05841236
53WNK11.05771141
54FGR1.04861747
55PHKG11.04527112
56PHKG21.04527112
57CSNK1G30.99359769
58STK30.99137511
59PRKCE0.95229902
60MET0.93881327
61NLK0.93398469
62SIK30.93048752
63MAP2K40.93030673
64GRK50.90267457
65CAMK2D0.85996372
66LIMK10.84860320
67IRAK20.84817194
68MAP3K20.84750794
69ROCK20.83729770
70NUAK10.83132832
71ERBB40.82950187
72OBSCN0.82037652
73TGFBR10.79094660
74CSNK1G10.78367792
75WEE10.77951771
76PAK30.77136906
77CAMK1G0.76442223
78BMPR1B0.75082481
79AKT30.71380549
80CAMKK20.70861582
81GRK70.70831067
82KSR10.70328227
83TIE10.70322402
84CDK140.69831139
85TGFBR20.69787531
86DYRK1A0.69273483
87PINK10.69053448
88ERBB30.67875214
89MARK20.66532844
90MAPK120.65236428
91PRKCG0.65124657
92MKNK10.65087987
93PIK3CA0.64851363
94CDK180.63947890
95YES10.62880565
96SGK10.62502533
97SGK30.62432498
98KSR20.62382622
99PDPK10.61853499
100SGK20.61502556
101CDK150.59805079
102CAMK2G0.59665488
103PTK2B0.59556635
104PRKG10.58984864
105EPHA30.55664484
106ADRBK20.55569329
107PLK30.55130218
108PRKCQ0.54277595
109FES0.53347913
110FYN0.53116365
111STK110.52609405
112TYRO30.52121356
113PRKCH0.52043308
114ROCK10.51359738
115CAMKK10.50547303
116CDK11A0.50348789
117FGFR10.48806575
118ADRBK10.48654704
119BRSK20.48346978
120PRKD30.47874755
121CDK30.47240918
122ARAF0.47014074
123STK240.46827776
124INSRR0.46676364
125WNK30.45390326
126MAP3K140.45359827
127PDK10.45039927
128TRPM70.44715849
129LATS10.44672468
130IRAK10.44233752
131FLT30.43736624
132ABL20.42600646
133PRKCZ0.42577828
134CSNK1D0.37724788
135EIF2AK20.36262326
136FGFR30.35341796
137CAMK10.34201976
138ERBB20.33654438
139MAP2K10.32191770
140ABL10.31894660
141PDGFRB0.30686513

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.97513029
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.89792493
3Protein export_Homo sapiens_hsa030602.62672943
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46202267
5Nicotine addiction_Homo sapiens_hsa050332.27044327
6Phototransduction_Homo sapiens_hsa047442.15233751
7Synaptic vesicle cycle_Homo sapiens_hsa047212.13423813
8Fatty acid elongation_Homo sapiens_hsa000622.13200186
9GABAergic synapse_Homo sapiens_hsa047272.08093098
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.01297978
11Glutamatergic synapse_Homo sapiens_hsa047241.99671604
12Morphine addiction_Homo sapiens_hsa050321.85291537
13Collecting duct acid secretion_Homo sapiens_hsa049661.82047611
14Propanoate metabolism_Homo sapiens_hsa006401.78634589
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76534617
16Ether lipid metabolism_Homo sapiens_hsa005651.74718794
17Circadian entrainment_Homo sapiens_hsa047131.74568356
18Circadian rhythm_Homo sapiens_hsa047101.73367682
19Serotonergic synapse_Homo sapiens_hsa047261.63359950
20Olfactory transduction_Homo sapiens_hsa047401.59944049
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.58108146
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52588240
23Axon guidance_Homo sapiens_hsa043601.48313680
24Long-term depression_Homo sapiens_hsa047301.47601129
25Dopaminergic synapse_Homo sapiens_hsa047281.39568996
26Salivary secretion_Homo sapiens_hsa049701.37711591
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37637726
28Long-term potentiation_Homo sapiens_hsa047201.31918661
29Regulation of autophagy_Homo sapiens_hsa041401.29092341
30Cholinergic synapse_Homo sapiens_hsa047251.28552129
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22879419
32Renin secretion_Homo sapiens_hsa049241.22095805
33Amphetamine addiction_Homo sapiens_hsa050311.17686212
34Gastric acid secretion_Homo sapiens_hsa049711.15769670
35Taste transduction_Homo sapiens_hsa047421.14939829
36Sphingolipid metabolism_Homo sapiens_hsa006001.14554962
37Sulfur metabolism_Homo sapiens_hsa009201.13040411
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08797928
39Butanoate metabolism_Homo sapiens_hsa006501.08773453
40Vibrio cholerae infection_Homo sapiens_hsa051101.06700639
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05923336
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05039655
43beta-Alanine metabolism_Homo sapiens_hsa004101.04261127
44Cocaine addiction_Homo sapiens_hsa050301.02325993
45Insulin secretion_Homo sapiens_hsa049111.00933882
46TGF-beta signaling pathway_Homo sapiens_hsa043501.00909943
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97154135
48Hedgehog signaling pathway_Homo sapiens_hsa043400.95902502
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93948153
50Rheumatoid arthritis_Homo sapiens_hsa053230.93863424
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91164672
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91132633
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87747505
54Oxytocin signaling pathway_Homo sapiens_hsa049210.87643320
55ErbB signaling pathway_Homo sapiens_hsa040120.86700006
56Nitrogen metabolism_Homo sapiens_hsa009100.84334989
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84316389
58Phagosome_Homo sapiens_hsa041450.83669893
59Histidine metabolism_Homo sapiens_hsa003400.83637076
60Basal transcription factors_Homo sapiens_hsa030220.82296938
61Hippo signaling pathway_Homo sapiens_hsa043900.82279515
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81063862
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81004296
64Calcium signaling pathway_Homo sapiens_hsa040200.80382142
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80025141
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78026386
67Oocyte meiosis_Homo sapiens_hsa041140.77931266
68Oxidative phosphorylation_Homo sapiens_hsa001900.76776322
69Ovarian steroidogenesis_Homo sapiens_hsa049130.76582763
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.76486266
71Mineral absorption_Homo sapiens_hsa049780.76132644
72Wnt signaling pathway_Homo sapiens_hsa043100.76033170
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75059209
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.74831991
75cAMP signaling pathway_Homo sapiens_hsa040240.74459959
76Dorso-ventral axis formation_Homo sapiens_hsa043200.74060885
77Selenocompound metabolism_Homo sapiens_hsa004500.73410341
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72863982
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72334949
80Ras signaling pathway_Homo sapiens_hsa040140.72038699
81Gap junction_Homo sapiens_hsa045400.70631526
82Renal cell carcinoma_Homo sapiens_hsa052110.70065607
83Linoleic acid metabolism_Homo sapiens_hsa005910.69659088
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68876262
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68793646
86GnRH signaling pathway_Homo sapiens_hsa049120.68231998
87ABC transporters_Homo sapiens_hsa020100.68059771
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67957257
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66894398
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66577705
91Tryptophan metabolism_Homo sapiens_hsa003800.66219907
92Alzheimers disease_Homo sapiens_hsa050100.64554307
93Non-homologous end-joining_Homo sapiens_hsa034500.62846222
94Inositol phosphate metabolism_Homo sapiens_hsa005620.61320211
95Glucagon signaling pathway_Homo sapiens_hsa049220.60826032
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.60355967
97Pancreatic secretion_Homo sapiens_hsa049720.60050995
98RNA degradation_Homo sapiens_hsa030180.58320634
99Melanogenesis_Homo sapiens_hsa049160.56740789
100Thyroid hormone synthesis_Homo sapiens_hsa049180.56400702
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55361896
102Lysosome_Homo sapiens_hsa041420.53840881
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53434674
104FoxO signaling pathway_Homo sapiens_hsa040680.52738584
105Bile secretion_Homo sapiens_hsa049760.52643861
106Choline metabolism in cancer_Homo sapiens_hsa052310.52139786
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51058119
108Melanoma_Homo sapiens_hsa052180.50466536
109Type II diabetes mellitus_Homo sapiens_hsa049300.50161033
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50050893
111Vitamin B6 metabolism_Homo sapiens_hsa007500.48552816
112Adherens junction_Homo sapiens_hsa045200.48081300
113Fatty acid metabolism_Homo sapiens_hsa012120.46502619
114Cardiac muscle contraction_Homo sapiens_hsa042600.45610588
115MAPK signaling pathway_Homo sapiens_hsa040100.44707321
116Endocytosis_Homo sapiens_hsa041440.44139225
117Prion diseases_Homo sapiens_hsa050200.42600914
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42319060
119Glioma_Homo sapiens_hsa052140.41887255
120Autoimmune thyroid disease_Homo sapiens_hsa053200.40490254
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.40378063
122Chemokine signaling pathway_Homo sapiens_hsa040620.39636507
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.38238600
124Tight junction_Homo sapiens_hsa045300.36678669
125Estrogen signaling pathway_Homo sapiens_hsa049150.36432353
126Salmonella infection_Homo sapiens_hsa051320.36179943
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35353370
128Dilated cardiomyopathy_Homo sapiens_hsa054140.34531660
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34356974
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34083765
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33489991
132Peroxisome_Homo sapiens_hsa041460.32661421

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