SAMD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sterile alpha motif domain-containing protein. The encoded protein localizes to the cytoplasm and may play a role in regulating cell proliferation and apoptosis. Mutations in this gene are the cause of normophosphatemic familial tumoral calcinosis. Alternate splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1type I interferon signaling pathway (GO:0060337)5.60181195
2cellular response to type I interferon (GO:0071357)5.60181195
3response to type I interferon (GO:0034340)5.55473617
4positive regulation of gamma-delta T cell activation (GO:0046645)5.54439927
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.14202522
6negative regulation of cell killing (GO:0031342)5.14202522
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.09963399
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.79409773
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.72961507
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.72961507
11modulation by symbiont of host immune response (GO:0052553)4.72961507
12positive regulation by symbiont of host defense response (GO:0052509)4.72961507
13modulation by symbiont of host defense response (GO:0052031)4.72961507
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.72961507
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.56344728
16response to interferon-alpha (GO:0035455)4.55309104
17antigen processing and presentation of endogenous antigen (GO:0019883)4.49291336
18positive regulation of interferon-alpha production (GO:0032727)4.48298345
19cellular response to interferon-alpha (GO:0035457)4.39505655
20regulation of interferon-alpha production (GO:0032647)4.38937410
21macrophage activation involved in immune response (GO:0002281)4.33239012
22detection of molecule of bacterial origin (GO:0032490)4.32795866
23regulation of interferon-beta biosynthetic process (GO:0045357)4.30254032
24regulation of B cell receptor signaling pathway (GO:0050855)4.16210211
25negative regulation of T cell mediated immunity (GO:0002710)4.07555765
26negative regulation of viral genome replication (GO:0045071)4.07401442
27negative regulation of interleukin-12 production (GO:0032695)4.06926650
28positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.03987487
29detection of other organism (GO:0098543)3.99143055
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.98372247
31regulation of gamma-delta T cell activation (GO:0046643)3.91103845
32response to peptidoglycan (GO:0032494)3.90029395
33T cell migration (GO:0072678)3.88288922
34interferon-gamma-mediated signaling pathway (GO:0060333)3.86218375
35detection of external biotic stimulus (GO:0098581)3.78659221
36response to host immune response (GO:0052572)3.69752146
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.69752146
38microglial cell activation (GO:0001774)3.66026425
39neutrophil activation involved in immune response (GO:0002283)3.59898171
40detection of bacterium (GO:0016045)3.58682629
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.50165729
42response to host (GO:0075136)3.50165729
43response to host defenses (GO:0052200)3.50165729
44immunoglobulin mediated immune response (GO:0016064)3.46718667
45regulation of gamma-delta T cell differentiation (GO:0045586)3.46087943
46response to interferon-beta (GO:0035456)3.44360535
47negative T cell selection (GO:0043383)3.42447185
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.42329377
49positive regulation of interferon-beta production (GO:0032728)3.40268329
50negative thymic T cell selection (GO:0045060)3.38710192
51regulation of type I interferon-mediated signaling pathway (GO:0060338)3.35925634
52cellular extravasation (GO:0045123)3.35325196
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.33997916
54response to interleukin-15 (GO:0070672)3.32714341
55positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.31911701
56detection of biotic stimulus (GO:0009595)3.25712987
57macrophage activation (GO:0042116)3.23887503
58defense response to virus (GO:0051607)3.20806007
59leukocyte aggregation (GO:0070486)3.19158198
60B cell receptor signaling pathway (GO:0050853)3.17849495
61antigen processing and presentation via MHC class Ib (GO:0002475)3.17176664
62cellular response to virus (GO:0098586)3.15197129
63regulation of RIG-I signaling pathway (GO:0039535)3.13614596
64regulation of necroptotic process (GO:0060544)3.10510030
65cellular response to exogenous dsRNA (GO:0071360)3.08380423
66cellular response to interleukin-15 (GO:0071350)3.08033837
67myeloid cell activation involved in immune response (GO:0002275)3.06990156
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03731175
69negative regulation of leukocyte mediated immunity (GO:0002704)3.01805656
70regulation of MHC class I biosynthetic process (GO:0045343)3.00927398
71regulation of tolerance induction (GO:0002643)2.99194687
72negative regulation of type 2 immune response (GO:0002829)2.99169415
73cellular response to interferon-beta (GO:0035458)2.99109315
74regulation of T cell tolerance induction (GO:0002664)2.98018806
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.97205918
76regulation of viral genome replication (GO:0045069)2.97004071
77defense response to protozoan (GO:0042832)2.95960874
78cellular response to interferon-gamma (GO:0071346)2.93641204
79positive regulation of type 2 immune response (GO:0002830)2.92779967
80positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.92742798
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92449059
82positive thymic T cell selection (GO:0045059)2.91176285
83positive regulation of toll-like receptor signaling pathway (GO:0034123)2.90918749
84regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89360508
85germinal center formation (GO:0002467)2.88968005
86regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.88518010
87regulation of type 2 immune response (GO:0002828)2.87862702
88regulation of interferon-beta production (GO:0032648)2.87479319
89regulation of alpha-beta T cell proliferation (GO:0046640)2.86221353
90regulation of regulatory T cell differentiation (GO:0045589)2.85991562
91hepatocyte apoptotic process (GO:0097284)2.85594680
92B cell mediated immunity (GO:0019724)2.84306486
93regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.83202521
94neutrophil activation (GO:0042119)2.81805406
95regulation of T-helper 1 cell differentiation (GO:0045625)2.79271191
96positive regulation of tolerance induction (GO:0002645)2.79187016
97neutrophil mediated immunity (GO:0002446)2.79108338
98regulation of dendritic cell antigen processing and presentation (GO:0002604)2.79037123
99positive T cell selection (GO:0043368)2.76272052
100NIK/NF-kappaB signaling (GO:0038061)2.75430326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human7.38978933
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.62339151
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.84746593
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.58926208
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.25298385
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.80006189
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.59250782
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.32936915
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.32665612
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.25446672
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20975539
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16828545
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93851882
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.91833234
15GATA1_22025678_ChIP-Seq_K562_Human2.62343790
16RUNX_20019798_ChIP-Seq_JUKART_Human2.61618142
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50352415
18MYB_26560356_Chip-Seq_TH2_Human2.50289511
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.47726472
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.46294214
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.46134558
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.33460735
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.24354447
24SPI1_23547873_ChIP-Seq_NB4_Human2.20684485
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17294354
26MYB_26560356_Chip-Seq_TH1_Human2.02979232
27SCL_19346495_ChIP-Seq_HPC-7_Human1.99758045
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.93714805
29MAF_26560356_Chip-Seq_TH1_Human1.92786547
30SPI1_23127762_ChIP-Seq_K562_Human1.90923269
31VDR_24763502_ChIP-Seq_THP-1_Human1.77524785
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75975586
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72762732
34GATA3_27048872_Chip-Seq_THYMUS_Human1.68013350
35VDR_24787735_ChIP-Seq_THP-1_Human1.66072018
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.65879061
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63396981
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54936354
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.52569743
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52421746
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52176950
42GATA3_26560356_Chip-Seq_TH2_Human1.50250123
43PU_27001747_Chip-Seq_BMDM_Mouse1.48216005
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.47774919
45UTX_26944678_Chip-Seq_JUKART_Human1.42724821
46VDR_21846776_ChIP-Seq_THP-1_Human1.41630008
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34250024
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33294110
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29591954
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27744657
51TCF7_22412390_ChIP-Seq_EML_Mouse1.24942608
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24684460
53MYC_22102868_ChIP-Seq_BL_Human1.24093943
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19651331
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.18736890
56MAF_26560356_Chip-Seq_TH2_Human1.18449861
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16309662
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15296071
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13977725
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13786738
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06434406
62GATA1_19941826_ChIP-Seq_K562_Human1.06097796
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01258024
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00279109
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99908666
66KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98343883
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97505287
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97482086
69* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96061917
70* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96061917
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94743799
72FOXO3_23340844_ChIP-Seq_DLD1_Human0.93976745
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93926221
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92281216
75GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92233694
76* GATA2_19941826_ChIP-Seq_K562_Human0.91328940
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90694136
78KDM2B_26808549_Chip-Seq_DND41_Human0.90576286
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89796998
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88865319
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88738805
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87538949
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86733227
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84409433
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84314964
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81874683
87TFEB_21752829_ChIP-Seq_HELA_Human0.80442038
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78737155
89* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78619682
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77850388
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74015405
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73086118
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72898066
94SMRT_27268052_Chip-Seq_Bcells_Human0.72894011
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.72847784
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.72565066
97* SOX2_20726797_ChIP-Seq_SW620_Human0.70095000
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70090583
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67970146
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.67058313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.35511339
2MP0001835_abnormal_antigen_presentation4.31903360
3MP0003303_peritoneal_inflammation3.56383440
4MP0009785_altered_susceptibility_to3.21733946
5MP0003436_decreased_susceptibility_to3.17935183
6MP0001800_abnormal_humoral_immune2.86729778
7MP0006082_CNS_inflammation2.83660488
8MP0005671_abnormal_response_to2.79010362
9MP0005000_abnormal_immune_tolerance2.75871452
10MP0005025_abnormal_response_to2.70278035
11MP0001790_abnormal_immune_system2.65135178
12MP0005387_immune_system_phenotype2.65135178
13MP0000685_abnormal_immune_system2.63868479
14MP0003300_gastrointestinal_ulcer2.60791725
15MP0003763_abnormal_thymus_physiology2.55269421
16MP0002419_abnormal_innate_immunity2.53849965
17MP0002723_abnormal_immune_serum2.50843030
18MP0002452_abnormal_antigen_presenting2.47854652
19MP0002148_abnormal_hypersensitivity_rea2.46373743
20MP0002420_abnormal_adaptive_immunity2.26141289
21MP0001819_abnormal_immune_cell2.25485881
22MP0002166_altered_tumor_susceptibility2.16535154
23MP0008260_abnormal_autophagy2.05510378
24MP0000569_abnormal_digit_pigmentation2.01256494
25MP0004947_skin_inflammation1.96595523
26MP0010155_abnormal_intestine_physiology1.95507864
27MP0005451_abnormal_body_composition1.89546153
28MP0002398_abnormal_bone_marrow1.81867201
29MP0003191_abnormal_cellular_cholesterol1.80573526
30MP0001533_abnormal_skeleton_physiology1.79365456
31MP0000716_abnormal_immune_system1.78138745
32MP0002405_respiratory_system_inflammati1.78047680
33MP0001845_abnormal_inflammatory_respons1.77776120
34MP0009333_abnormal_splenocyte_physiolog1.73831057
35MP0005464_abnormal_platelet_physiology1.69849669
36MP0002006_tumorigenesis1.67250225
37MP0009764_decreased_sensitivity_to1.54899650
38MP0008469_abnormal_protein_level1.46434163
39MP0002722_abnormal_immune_system1.46106288
40MP0000689_abnormal_spleen_morphology1.45657042
41MP0000858_altered_metastatic_potential1.44064427
42MP0000465_gastrointestinal_hemorrhage1.42318054
43MP0002429_abnormal_blood_cell1.41083872
44MP0004883_abnormal_blood_vessel1.40412971
45MP0003866_abnormal_defecation1.37692313
46MP0003172_abnormal_lysosome_physiology1.35435796
47MP0003656_abnormal_erythrocyte_physiolo1.35048121
48MP0005310_abnormal_salivary_gland1.34651026
49MP0005164_abnormal_response_to1.34076179
50MP0003828_pulmonary_edema1.34034340
51MP0003448_altered_tumor_morphology1.30354562
52MP0001853_heart_inflammation1.29365148
53MP0000703_abnormal_thymus_morphology1.28862168
54MP0004381_abnormal_hair_follicle1.28709919
55MP0001545_abnormal_hematopoietic_system1.24120746
56MP0005397_hematopoietic_system_phenotyp1.24120746
57MP0002396_abnormal_hematopoietic_system1.24102395
58MP0003091_abnormal_cell_migration1.20612052
59MP0002998_abnormal_bone_remodeling1.19164079
60MP0003075_altered_response_to1.17469031
61MP0004808_abnormal_hematopoietic_stem1.17424264
62MP0003045_fibrosis1.14911606
63MP0003183_abnormal_peptide_metabolism1.14755097
64MP0005166_decreased_susceptibility_to1.12938460
65MP0002332_abnormal_exercise_endurance1.11570454
66MP0009278_abnormal_bone_marrow1.07337181
67MP0001851_eye_inflammation1.07151456
68MP0000343_altered_response_to1.03686948
69MP0002877_abnormal_melanocyte_morpholog1.02700032
70MP0004510_myositis1.01348089
71MP0003221_abnormal_cardiomyocyte_apopto0.99428418
72MP0003690_abnormal_glial_cell0.97686957
73MP0003453_abnormal_keratinocyte_physiol0.97319151
74MP0008004_abnormal_stomach_pH0.97312942
75MP0009763_increased_sensitivity_to0.96673665
76MP0010352_gastrointestinal_tract_polyps0.96333693
77MP0006054_spinal_hemorrhage0.94690949
78MP0008057_abnormal_DNA_replication0.93324768
79MP0005058_abnormal_lysosome_morphology0.93183689
80MP0000015_abnormal_ear_pigmentation0.91255340
81MP0000604_amyloidosis0.88020481
82MP0010234_abnormal_vibrissa_follicle0.84970462
83MP0001873_stomach_inflammation0.84809072
84MP0002009_preneoplasia0.76804667
85MP0002132_abnormal_respiratory_system0.76784508
86MP0000249_abnormal_blood_vessel0.74513173
87MP0003806_abnormal_nucleotide_metabolis0.73242304
88MP0005075_abnormal_melanosome_morpholog0.72663769
89MP0005023_abnormal_wound_healing0.70550041
90MP0005390_skeleton_phenotype0.69761806
91MP0001663_abnormal_digestive_system0.69657433
92MP0001958_emphysema0.69194623
93MP0009765_abnormal_xenobiotic_induced0.65975706
94MP0002933_joint_inflammation0.65736887
95MP0003795_abnormal_bone_structure0.65197379
96MP0000371_diluted_coat_color0.64741383
97MP0003566_abnormal_cell_adhesion0.64657970
98MP0008874_decreased_physiological_sensi0.62564191
99MP0003705_abnormal_hypodermis_morpholog0.62416333
100MP0002019_abnormal_tumor_incidence0.61848156

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.38803658
2Eczematoid dermatitis (HP:0000976)5.30287314
3T lymphocytopenia (HP:0005403)4.90389552
4Recurrent abscess formation (HP:0002722)4.89534088
5Optic neuritis (HP:0100653)4.76678972
6Retrobulbar optic neuritis (HP:0100654)4.76678972
7Orchitis (HP:0100796)4.74238496
8Myositis (HP:0100614)4.69973022
9Abnormality of T cell number (HP:0011839)4.68716033
10Recurrent fungal infections (HP:0002841)4.22386376
11Chronic mucocutaneous candidiasis (HP:0002728)4.02245685
12Recurrent cutaneous fungal infections (HP:0011370)4.02245685
13Recurrent viral infections (HP:0004429)3.97254089
14Elevated erythrocyte sedimentation rate (HP:0003565)3.94870103
15Abnormality of macrophages (HP:0004311)3.94003075
16Recurrent skin infections (HP:0001581)3.89893572
17Stomatitis (HP:0010280)3.77127209
18Gastrointestinal infarctions (HP:0005244)3.74143257
19Mediastinal lymphadenopathy (HP:0100721)3.68706891
20Keratoconjunctivitis sicca (HP:0001097)3.63514618
21Vasculitis (HP:0002633)3.50928996
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.47851823
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.43985440
24Recurrent gram-negative bacterial infections (HP:0005420)3.36619452
25Meningitis (HP:0001287)3.33418335
26Keratoconjunctivitis (HP:0001096)3.28006405
27Abnormality of T cells (HP:0002843)3.21306833
28Autoimmune hemolytic anemia (HP:0001890)3.19218580
29Pulmonary infiltrates (HP:0002113)3.15640008
30Hemoptysis (HP:0002105)3.14892779
31Spontaneous hematomas (HP:0007420)3.13854164
32Recurrent bronchitis (HP:0002837)3.05107210
33Encephalitis (HP:0002383)3.04958064
34Arterial thrombosis (HP:0004420)2.97086516
35Gingival bleeding (HP:0000225)2.96810626
36* Gingivitis (HP:0000230)2.86237856
37Chronic obstructive pulmonary disease (HP:0006510)2.84392365
38Obstructive lung disease (HP:0006536)2.84392365
39Peritonitis (HP:0002586)2.84175853
40Urticaria (HP:0001025)2.82567310
41Leukocytosis (HP:0001974)2.80393724
42Cellulitis (HP:0100658)2.72357311
43Increased IgM level (HP:0003496)2.68207796
44Chest pain (HP:0100749)2.66020503
45Pustule (HP:0200039)2.63262839
46Increased IgE level (HP:0003212)2.62465049
47Inflammation of the large intestine (HP:0002037)2.58444334
48Eosinophilia (HP:0001880)2.54337668
49Granulocytopenia (HP:0001913)2.53181693
50Cheilitis (HP:0100825)2.52819130
51Colitis (HP:0002583)2.52532325
52Gangrene (HP:0100758)2.50801777
53Hypergammaglobulinemia (HP:0010702)2.49332306
54Gastrointestinal inflammation (HP:0004386)2.43570312
55Autoimmune thrombocytopenia (HP:0001973)2.41372539
56Anorexia (HP:0002039)2.34557966
57Epistaxis (HP:0000421)2.34441113
58Abnormality of B cell number (HP:0010975)2.34020399
59Subacute progressive viral hepatitis (HP:0006572)2.32796594
60Osteomyelitis (HP:0002754)2.31986471
61Chronic diarrhea (HP:0002028)2.28238768
62Panhypogammaglobulinemia (HP:0003139)2.25527512
63Pulmonary embolism (HP:0002204)2.25342353
64Abnormality of T cell physiology (HP:0011840)2.25151338
65Viral hepatitis (HP:0006562)2.23014945
66Skin ulcer (HP:0200042)2.16868167
67Abnormality of eosinophils (HP:0001879)2.16687675
68Prolonged bleeding time (HP:0003010)2.16311484
69Interstitial pulmonary disease (HP:0006530)2.15630675
70Periodontitis (HP:0000704)2.14645059
71Abnormality of the endocardium (HP:0004306)2.13170128
72Abnormality of the pleura (HP:0002103)2.13107039
73Glomerulopathy (HP:0100820)2.12986781
74Slow saccadic eye movements (HP:0000514)2.11921686
75Abnormality of the peritoneum (HP:0002585)2.08958636
76Sepsis (HP:0100806)2.07640791
77Abnormality of glycolipid metabolism (HP:0010969)2.07200981
78Abnormality of liposaccharide metabolism (HP:0010968)2.07200981
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.07200981
80Fatigue (HP:0012378)2.06377901
81B lymphocytopenia (HP:0010976)2.04464258
82Chronic otitis media (HP:0000389)2.03546422
83Hematochezia (HP:0002573)2.02944771
84IgA deficiency (HP:0002720)2.02601507
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.01669329
86Loss of speech (HP:0002371)2.01212581
87IgG deficiency (HP:0004315)2.01016348
88Agammaglobulinemia (HP:0004432)2.00885019
89Lymphopenia (HP:0001888)1.98371336
90Basal ganglia calcification (HP:0002135)1.97545469
91Acute hepatic failure (HP:0006554)1.96910083
92Keratitis (HP:0000491)1.96145823
93Joint swelling (HP:0001386)1.96050764
94Episodic fever (HP:0001954)1.90682968
95Abnormality of the pericardium (HP:0001697)1.87072496
96Thyroiditis (HP:0100646)1.86474351
97Amaurosis fugax (HP:0100576)1.83405205
98Abnormality of the vasculature of the conjunctiva (HP:0008054)1.82770358
99Skin rash (HP:0000988)1.82195095
100Verrucae (HP:0200043)1.82128519

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK23.81487135
2RIPK43.37548878
3IKBKE3.18527908
4BLK3.13460943
5JAK33.06645601
6MAP4K12.98736431
7JAK12.90692878
8MAP3K142.72532975
9IRAK42.58606098
10FGFR42.46189855
11PRPF4B2.38217932
12CSK2.36521467
13TXK2.28588676
14FGFR32.16713373
15BMPR21.96995434
16MAP2K31.96304996
17TBK11.86325648
18KIT1.81996044
19ZAP701.77419295
20BTK1.70857068
21MAP3K131.70162999
22FES1.60649174
23SYK1.59161190
24FGR1.52243706
25ERN11.50784692
26GRK61.45721983
27IRAK31.40821353
28TAOK31.39324094
29JAK21.39000728
30MAP3K31.33811528
31TEC1.32853517
32HCK1.32106928
33ITK1.29901434
34PIK3CG1.27504403
35IKBKB1.24610650
36GRK71.22834932
37LYN1.21588561
38STK101.21363123
39IRAK11.20880776
40EPHB11.20731312
41LCK1.18707633
42RIPK11.17315262
43MAP3K21.14178457
44TGFBR21.11475586
45MATK1.06822191
46CAMKK21.04321909
47CSF1R1.00623472
48NEK90.99697250
49MAP3K10.98868930
50IRAK20.89833110
51SIK30.89311104
52YES10.87324404
53NLK0.87135093
54LRRK20.84245885
55MARK30.81242753
56MAPK110.80308931
57TAOK20.77052826
58MAP3K60.75724649
59TAOK10.73887139
60PIM10.70327999
61TRPM70.68521821
62HIPK20.68231743
63CDC42BPA0.64671347
64KSR20.62993695
65CDK60.60357551
66TNK20.60209904
67PDK10.59935384
68CDK120.58946602
69MAP3K50.57417160
70WNK10.57391783
71CHUK0.56117463
72MAPK70.54958311
73MELK0.54721004
74PTK2B0.54412867
75MAP3K110.49299560
76MARK20.49193258
77MOS0.49025367
78PRKCQ0.48948497
79STK40.47486178
80SGK30.45524847
81MST1R0.45362784
82EGFR0.42227734
83MAP3K100.42129027
84ACVR1B0.42114935
85PDGFRB0.41949587
86STK240.41916442
87FYN0.41680216
88CDK40.41402229
89KSR10.40408737
90RAF10.39090130
91EPHA30.38315039
92CLK10.38121850
93PDPK10.36718491
94SGK20.33126635
95ABL10.31895592
96MAPKAPK20.30918011
97MAP3K120.28214039
98RET0.28109451
99BRD40.27823692
100MAP2K60.27026615

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.81866707
2RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.56501119
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.55816001
4Measles_Homo sapiens_hsa051622.55684209
5Osteoclast differentiation_Homo sapiens_hsa043802.52948879
6Allograft rejection_Homo sapiens_hsa053302.46781540
7Graft-versus-host disease_Homo sapiens_hsa053322.41283938
8Autoimmune thyroid disease_Homo sapiens_hsa053202.29868053
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26724158
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.23876762
11Influenza A_Homo sapiens_hsa051642.21760106
12Staphylococcus aureus infection_Homo sapiens_hsa051502.15135779
13B cell receptor signaling pathway_Homo sapiens_hsa046622.07100279
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.03769148
15Primary immunodeficiency_Homo sapiens_hsa053402.00334147
16Tuberculosis_Homo sapiens_hsa051521.95249690
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.95096138
18Herpes simplex infection_Homo sapiens_hsa051681.82743257
19Asthma_Homo sapiens_hsa053101.82052181
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.76887739
21Toxoplasmosis_Homo sapiens_hsa051451.76103717
22Hepatitis C_Homo sapiens_hsa051601.74640467
23Malaria_Homo sapiens_hsa051441.73014019
24Type I diabetes mellitus_Homo sapiens_hsa049401.69673569
25TNF signaling pathway_Homo sapiens_hsa046681.67723268
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66293430
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.65948939
28Antigen processing and presentation_Homo sapiens_hsa046121.65730450
29T cell receptor signaling pathway_Homo sapiens_hsa046601.64041939
30Hematopoietic cell lineage_Homo sapiens_hsa046401.59877245
31Hepatitis B_Homo sapiens_hsa051611.57537388
32Legionellosis_Homo sapiens_hsa051341.56070034
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44133086
34Viral myocarditis_Homo sapiens_hsa054161.42836335
35Chemokine signaling pathway_Homo sapiens_hsa040621.41265018
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38350306
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35495362
38Acute myeloid leukemia_Homo sapiens_hsa052211.35476476
39African trypanosomiasis_Homo sapiens_hsa051431.26945005
40Rheumatoid arthritis_Homo sapiens_hsa053231.19964963
41Pancreatic cancer_Homo sapiens_hsa052121.17283679
42Pertussis_Homo sapiens_hsa051331.17157915
43Non-small cell lung cancer_Homo sapiens_hsa052231.16222347
44Apoptosis_Homo sapiens_hsa042101.11774365
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08437614
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08001388
47Prolactin signaling pathway_Homo sapiens_hsa049171.04794875
48Phagosome_Homo sapiens_hsa041451.03375589
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.96798678
50Chronic myeloid leukemia_Homo sapiens_hsa052200.95807163
51Platelet activation_Homo sapiens_hsa046110.95071864
52Salmonella infection_Homo sapiens_hsa051320.93768547
53Shigellosis_Homo sapiens_hsa051310.93409182
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92178541
55Other glycan degradation_Homo sapiens_hsa005110.91796818
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88502803
57VEGF signaling pathway_Homo sapiens_hsa043700.80726501
58Dorso-ventral axis formation_Homo sapiens_hsa043200.78927866
59Viral carcinogenesis_Homo sapiens_hsa052030.76612124
60Epstein-Barr virus infection_Homo sapiens_hsa051690.74682458
61Renal cell carcinoma_Homo sapiens_hsa052110.72203563
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.71308438
63Amoebiasis_Homo sapiens_hsa051460.69679613
64FoxO signaling pathway_Homo sapiens_hsa040680.69324730
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62841870
66Small cell lung cancer_Homo sapiens_hsa052220.62350451
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60287090
68HTLV-I infection_Homo sapiens_hsa051660.58928492
69Lysosome_Homo sapiens_hsa041420.58723137
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.58235574
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57889343
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.55807192
73mTOR signaling pathway_Homo sapiens_hsa041500.54398223
74Endometrial cancer_Homo sapiens_hsa052130.52242859
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52056779
76Inositol phosphate metabolism_Homo sapiens_hsa005620.51031153
77Endocytosis_Homo sapiens_hsa041440.50967859
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50499568
79HIF-1 signaling pathway_Homo sapiens_hsa040660.49160757
80Prostate cancer_Homo sapiens_hsa052150.46799519
81Notch signaling pathway_Homo sapiens_hsa043300.44598066
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43905687
83Insulin resistance_Homo sapiens_hsa049310.42550071
84Bladder cancer_Homo sapiens_hsa052190.42193216
85Glioma_Homo sapiens_hsa052140.40921441
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.39679678
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39400380
88Proteoglycans in cancer_Homo sapiens_hsa052050.39336908
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38509582
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38041627
91GnRH signaling pathway_Homo sapiens_hsa049120.37939058
92Systemic lupus erythematosus_Homo sapiens_hsa053220.37705339
93ErbB signaling pathway_Homo sapiens_hsa040120.36178562
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32040926
95Type II diabetes mellitus_Homo sapiens_hsa049300.32028275
96Choline metabolism in cancer_Homo sapiens_hsa052310.31743045
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31131493
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30486977
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30473997
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30049266

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