SAMHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.49565778
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.49565778
3antigen processing and presentation of endogenous antigen (GO:0019883)6.26435891
4positive regulation of gamma-delta T cell activation (GO:0046645)5.43951286
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.00191464
6detection of other organism (GO:0098543)4.70521946
7response to type I interferon (GO:0034340)4.62639025
8cellular response to type I interferon (GO:0071357)4.59476119
9type I interferon signaling pathway (GO:0060337)4.59476119
10positive regulation of interferon-alpha production (GO:0032727)4.56169212
11negative regulation of interleukin-12 production (GO:0032695)4.48456285
12detection of bacterium (GO:0016045)4.40115717
13detection of molecule of bacterial origin (GO:0032490)4.39943251
14positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.37604503
15regulation of interferon-alpha production (GO:0032647)4.35830733
16positive regulation by symbiont of host defense response (GO:0052509)4.24311002
17modulation by symbiont of host defense response (GO:0052031)4.24311002
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.24311002
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.24311002
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.24311002
21modulation by symbiont of host immune response (GO:0052553)4.24311002
22detection of external biotic stimulus (GO:0098581)4.22155490
23regulation of interleukin-12 biosynthetic process (GO:0045075)4.08383733
24T cell migration (GO:0072678)4.05693287
25negative thymic T cell selection (GO:0045060)4.04532735
26negative regulation of cell killing (GO:0031342)3.98453502
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.98453502
28immunoglobulin mediated immune response (GO:0016064)3.98252152
29interferon-gamma-mediated signaling pathway (GO:0060333)3.96820405
30regulation of B cell receptor signaling pathway (GO:0050855)3.92407948
31microglial cell activation (GO:0001774)3.92321853
32regulation of interferon-beta biosynthetic process (GO:0045357)3.90298798
33negative T cell selection (GO:0043383)3.89373594
34neutrophil activation involved in immune response (GO:0002283)3.88427001
35NIK/NF-kappaB signaling (GO:0038061)3.87322154
36positive regulation of mast cell activation (GO:0033005)3.86305138
37regulation of T cell tolerance induction (GO:0002664)3.80301535
38regulation of gamma-delta T cell differentiation (GO:0045586)3.79369333
39regulation of gamma-delta T cell activation (GO:0046643)3.78548968
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.76778657
41regulation of alpha-beta T cell proliferation (GO:0046640)3.74508777
42detection of biotic stimulus (GO:0009595)3.73724497
43positive thymic T cell selection (GO:0045059)3.68580461
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.68247481
45regulation of type I interferon-mediated signaling pathway (GO:0060338)3.67926412
46positive regulation of antigen processing and presentation (GO:0002579)3.67296865
47negative regulation of T cell mediated immunity (GO:0002710)3.63964785
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.61520400
49regulation of mast cell degranulation (GO:0043304)3.61304747
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.59836097
51leukocyte aggregation (GO:0070486)3.59151743
52macrophage activation (GO:0042116)3.54370870
53response to peptidoglycan (GO:0032494)3.52138465
54positive regulation of mast cell activation involved in immune response (GO:0033008)3.49387594
55positive regulation of mast cell degranulation (GO:0043306)3.49387594
56positive regulation of interferon-beta production (GO:0032728)3.39263477
57neutrophil activation (GO:0042119)3.38474772
58cellular response to interferon-beta (GO:0035458)3.36056803
59myeloid dendritic cell activation (GO:0001773)3.36043225
60regulation of myeloid leukocyte mediated immunity (GO:0002886)3.35255196
61JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.35116681
62regulation of dendritic cell antigen processing and presentation (GO:0002604)3.34255220
63regulation of mast cell activation (GO:0033003)3.33928283
64myeloid dendritic cell differentiation (GO:0043011)3.33590560
65regulation of mast cell activation involved in immune response (GO:0033006)3.33349487
66negative regulation of leukocyte mediated immunity (GO:0002704)3.32387259
67macrophage activation involved in immune response (GO:0002281)3.30348005
68granulocyte activation (GO:0036230)3.30264069
69regulation of antigen processing and presentation (GO:0002577)3.29896720
70defense response to protozoan (GO:0042832)3.28896085
71natural killer cell mediated immunity (GO:0002228)3.27025754
72natural killer cell mediated cytotoxicity (GO:0042267)3.27025754
73regulation of leukocyte degranulation (GO:0043300)3.26591664
74respiratory burst (GO:0045730)3.26046010
75regulation of RIG-I signaling pathway (GO:0039535)3.25883613
76positive regulation of alpha-beta T cell proliferation (GO:0046641)3.25842104
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.23794821
78response to muramyl dipeptide (GO:0032495)3.23757899
79thymic T cell selection (GO:0045061)3.22629966
80positive regulation of tolerance induction (GO:0002645)3.21380584
81regulation of B cell differentiation (GO:0045577)3.20720566
82positive regulation of natural killer cell differentiation (GO:0032825)3.20511817
83B cell receptor signaling pathway (GO:0050853)3.19884852
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.19381613
85tolerance induction (GO:0002507)3.18435896
86positive regulation of cellular amide metabolic process (GO:0034250)3.17004831
87B cell mediated immunity (GO:0019724)3.16818322
88response to interferon-alpha (GO:0035455)3.16374689
89T cell selection (GO:0045058)3.15832242
90positive regulation of B cell differentiation (GO:0045579)3.13863665
91response to interleukin-15 (GO:0070672)3.11296389
92regulation of T-helper 1 cell differentiation (GO:0045625)3.11255482
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.11227044
94regulation of tolerance induction (GO:0002643)3.10801334
95positive regulation of isotype switching (GO:0045830)3.10544016
96positive regulation of interleukin-12 production (GO:0032735)3.10139530
97cellular response to interferon-gamma (GO:0071346)3.09082406
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.08830039
99response to host immune response (GO:0052572)3.08830039
100positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.08717464
101response to protozoan (GO:0001562)3.07909406
102activated T cell proliferation (GO:0050798)3.04611429
103regulation of response to interferon-gamma (GO:0060330)3.03637567
104positive regulation of interleukin-2 production (GO:0032743)3.01942008
105positive regulation of humoral immune response (GO:0002922)3.01352983
106cellular response to virus (GO:0098586)3.01334631
107cellular response to zinc ion (GO:0071294)2.99623024
108neutrophil mediated immunity (GO:0002446)2.99096577
109regulation of isotype switching to IgG isotypes (GO:0048302)2.97873489
110production of molecular mediator involved in inflammatory response (GO:0002532)2.96662160
111lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95489487
112regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95295990
113antigen processing and presentation via MHC class Ib (GO:0002475)2.93681636
114positive regulation of type 2 immune response (GO:0002830)2.92197518
115leukocyte cell-cell adhesion (GO:0007159)2.91656861
116interferon-gamma production (GO:0032609)2.91363607
117positive regulation of leukocyte degranulation (GO:0043302)2.90668438
118Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89531145
119regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.88617198
120negative regulation of erythrocyte differentiation (GO:0045647)2.87594041
121positive T cell selection (GO:0043368)2.86779219
122regulation of interleukin-12 production (GO:0032655)2.86676721
123myeloid cell activation involved in immune response (GO:0002275)2.84999739
124cellular extravasation (GO:0045123)2.84743665
125response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.84188679
126response to host (GO:0075136)2.84188679
127response to host defenses (GO:0052200)2.84188679
128response to interferon-beta (GO:0035456)2.83451441
129negative regulation of viral genome replication (GO:0045071)2.82912503
130negative regulation of cytokine production involved in immune response (GO:0002719)2.82834076
131regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.82325032
132positive regulation of cytokine biosynthetic process (GO:0042108)2.79694396
133myeloid leukocyte activation (GO:0002274)2.79385922
134regulation of T-helper 2 cell differentiation (GO:0045628)2.78640439
135dendritic cell migration (GO:0036336)2.77230470
136regulation of hypersensitivity (GO:0002883)2.75595650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.70969309
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.69598168
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.44177506
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.82372858
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.65281749
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.28268756
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.67256095
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.31275150
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30416580
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.25337926
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.24870068
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15615997
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.10508714
14* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.07726381
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.98868871
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65989686
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60932380
18MYB_26560356_Chip-Seq_TH2_Human2.51955540
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.45482983
20E2F7_22180533_ChIP-Seq_HELA_Human2.40922553
21RUNX_20019798_ChIP-Seq_JUKART_Human2.38347363
22* MAF_26560356_Chip-Seq_TH1_Human2.37101659
23* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.37046469
24MYB_26560356_Chip-Seq_TH1_Human2.17962777
25MYC_22102868_ChIP-Seq_BL_Human2.14960957
26SPI1_23547873_ChIP-Seq_NB4_Human2.14904327
27VDR_21846776_ChIP-Seq_THP-1_Human2.06398821
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01658880
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01545374
30* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.97073108
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89033550
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87269951
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85812101
34* RUNX1_22412390_ChIP-Seq_EML_Mouse1.80560039
35UTX_26944678_Chip-Seq_JUKART_Human1.79701778
36VDR_24763502_ChIP-Seq_THP-1_Human1.76491955
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75626527
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70178350
39SCL_19346495_ChIP-Seq_HPC-7_Human1.64573563
40PU_27001747_Chip-Seq_BMDM_Mouse1.59247360
41SPI1_23127762_ChIP-Seq_K562_Human1.58646638
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53649661
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52882849
44GATA1_22025678_ChIP-Seq_K562_Human1.52641572
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52559068
46GATA3_27048872_Chip-Seq_THYMUS_Human1.52426080
47MAF_26560356_Chip-Seq_TH2_Human1.52287901
48* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49631457
49TCF7_22412390_ChIP-Seq_EML_Mouse1.49582671
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47401781
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46383433
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39713092
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38082564
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33767046
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32790242
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28522642
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.22768590
58GATA3_26560356_Chip-Seq_TH2_Human1.21867698
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21761530
60KDM2B_26808549_Chip-Seq_DND41_Human1.20727777
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18221964
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16957502
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.13886285
64GATA1_19941826_ChIP-Seq_K562_Human1.13721460
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.11478025
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10911207
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08283481
68VDR_24787735_ChIP-Seq_THP-1_Human1.07556647
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05760416
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05500485
71* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05063531
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04363888
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02914729
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.02310416
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02269691
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02159057
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01047472
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00129502
79GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98539659
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98371654
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98349516
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97217194
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96441084
84ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94609765
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92251097
86GATA2_19941826_ChIP-Seq_K562_Human0.91995459
87IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88931161
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86792959
89GATA2_21666600_ChIP-Seq_HMVEC_Human0.85528149
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85169485
91SMRT_27268052_Chip-Seq_Bcells_Human0.84889071
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84794154
93FOXM1_23109430_ChIP-Seq_U2OS_Human0.84589942
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.83771813
95* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82345434
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82268121
97GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81106049
98TFEB_21752829_ChIP-Seq_HELA_Human0.79681382
99LXR_22292898_ChIP-Seq_THP-1_Human0.78923917
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77769779
101NCOR1_26117541_ChIP-Seq_K562_Human0.77675932
102STAT1_20625510_ChIP-Seq_HELA_Human0.76238870
103* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75068254
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74981256
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74560446
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74150592
107BCL6_27268052_Chip-Seq_Bcells_Human0.73535710
108SPI1_20517297_ChIP-Seq_HL60_Human0.73067786
109EGR1_19032775_ChIP-ChIP_M12_Human0.71855345
110HOXB4_20404135_ChIP-ChIP_EML_Mouse0.71431917
111RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70929751
112LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.65207769
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.64553476
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.64553476
115KDM2B_26808549_Chip-Seq_JURKAT_Human0.64284028
116CIITA_25753668_ChIP-Seq_RAJI_Human0.63397154
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.62111621
118* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.61959560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.72065159
2MP0000685_abnormal_immune_system3.48957468
3MP0005387_immune_system_phenotype3.43205260
4MP0001790_abnormal_immune_system3.43205260
5MP0003436_decreased_susceptibility_to3.31497559
6MP0009785_altered_susceptibility_to3.27852751
7MP0005671_abnormal_response_to3.23129746
8MP0001800_abnormal_humoral_immune3.18123745
9MP0003303_peritoneal_inflammation3.12470447
10MP0005000_abnormal_immune_tolerance3.06734902
11MP0002452_abnormal_antigen_presenting2.89302883
12MP0002148_abnormal_hypersensitivity_rea2.88551388
13MP0004510_myositis2.87608423
14MP0005025_abnormal_response_to2.82411448
15MP0002723_abnormal_immune_serum2.75443384
16MP0002419_abnormal_innate_immunity2.65347709
17MP0006082_CNS_inflammation2.59277881
18MP0001819_abnormal_immune_cell2.58083715
19MP0002420_abnormal_adaptive_immunity2.56713690
20MP0003763_abnormal_thymus_physiology2.42092033
21MP0002166_altered_tumor_susceptibility2.34227270
22MP0003724_increased_susceptibility_to2.30912892
23MP0002398_abnormal_bone_marrow2.16600381
24MP0002405_respiratory_system_inflammati2.09065345
25MP0000716_abnormal_immune_system2.06705958
26MP0002006_tumorigenesis2.06680801
27MP0004947_skin_inflammation2.02309726
28MP0003300_gastrointestinal_ulcer1.97706836
29MP0010155_abnormal_intestine_physiology1.93580700
30MP0001853_heart_inflammation1.89624603
31MP0005464_abnormal_platelet_physiology1.86069912
32MP0009333_abnormal_splenocyte_physiolog1.84387081
33MP0008260_abnormal_autophagy1.83022570
34MP0001845_abnormal_inflammatory_respons1.81826608
35MP0001533_abnormal_skeleton_physiology1.75967678
36MP0000689_abnormal_spleen_morphology1.75733667
37MP0002429_abnormal_blood_cell1.68957900
38MP0002722_abnormal_immune_system1.67866213
39MP0003448_altered_tumor_morphology1.67281548
40MP0005058_abnormal_lysosome_morphology1.67010043
41MP0001873_stomach_inflammation1.65717244
42MP0002396_abnormal_hematopoietic_system1.65030835
43MP0004883_abnormal_blood_vessel1.59381332
44MP0005310_abnormal_salivary_gland1.57141554
45MP0005451_abnormal_body_composition1.56604714
46MP0003690_abnormal_glial_cell1.50612381
47MP0009278_abnormal_bone_marrow1.48114640
48MP0008469_abnormal_protein_level1.45102537
49MP0000858_altered_metastatic_potential1.43032838
50MP0004808_abnormal_hematopoietic_stem1.39545268
51MP0000703_abnormal_thymus_morphology1.36794313
52MP0000569_abnormal_digit_pigmentation1.36167553
53MP0001545_abnormal_hematopoietic_system1.36023768
54MP0005397_hematopoietic_system_phenotyp1.36023768
55MP0009764_decreased_sensitivity_to1.35484879
56MP0002138_abnormal_hepatobiliary_system1.35229090
57MP0002933_joint_inflammation1.32829817
58MP0008004_abnormal_stomach_pH1.23092283
59MP0002998_abnormal_bone_remodeling1.20775719
60MP0002132_abnormal_respiratory_system1.19330686
61MP0000343_altered_response_to1.16822479
62MP0003866_abnormal_defecation1.16442606
63MP0005076_abnormal_cell_differentiation1.14873069
64MP0010352_gastrointestinal_tract_polyps1.10806578
65MP0010307_abnormal_tumor_latency1.10629897
66MP0002277_abnormal_respiratory_mucosa1.08371192
67MP0003172_abnormal_lysosome_physiology1.08369401
68MP0001851_eye_inflammation1.06318273
69MP0000465_gastrointestinal_hemorrhage1.02444395
70MP0003566_abnormal_cell_adhesion1.02274447
71MP0003191_abnormal_cellular_cholesterol0.95529128
72MP0004381_abnormal_hair_follicle0.94423147
73MP0005174_abnormal_tail_pigmentation0.92617416
74MP0000490_abnormal_crypts_of0.91284539
75MP0002254_reproductive_system_inflammat0.89155184
76MP0003091_abnormal_cell_migration0.88095845
77MP0003453_abnormal_keratinocyte_physiol0.87099830
78MP0003656_abnormal_erythrocyte_physiolo0.86887784
79MP0005023_abnormal_wound_healing0.85081081
80MP0000604_amyloidosis0.83997691
81MP0005390_skeleton_phenotype0.81173253
82MP0009763_increased_sensitivity_to0.80804619
83MP0003045_fibrosis0.80354001
84MP0009840_abnormal_foam_cell0.79791403
85MP0002019_abnormal_tumor_incidence0.79789221
86MP0002009_preneoplasia0.78714625
87MP0003806_abnormal_nucleotide_metabolis0.78433311
88MP0005166_decreased_susceptibility_to0.74706475
89MP0003075_altered_response_to0.71902108
90MP0003329_amyloid_beta_deposits0.69626849
91MP0000249_abnormal_blood_vessel0.68018735
92MP0000920_abnormal_myelination0.66665512
93MP0001958_emphysema0.65930404
94MP0002136_abnormal_kidney_physiology0.64773145
95MP0005075_abnormal_melanosome_morpholog0.64251809
96MP0004130_abnormal_muscle_cell0.63621927
97MP0003795_abnormal_bone_structure0.63277495
98MP0005164_abnormal_response_to0.63060040
99MP0004782_abnormal_surfactant_physiolog0.61027982
100MP0002332_abnormal_exercise_endurance0.60828400
101MP0000767_abnormal_smooth_muscle0.60485154
102MP0003828_pulmonary_edema0.59304777
103MP0003279_aneurysm0.59300167
104MP0000371_diluted_coat_color0.59283954
105MP0003183_abnormal_peptide_metabolism0.58812982
106MP0006054_spinal_hemorrhage0.58432422
107MP0001986_abnormal_taste_sensitivity0.58033209
108MP0005388_respiratory_system_phenotype0.57349400
109MP0002133_abnormal_respiratory_system0.57349400
110MP0009115_abnormal_fat_cell0.56438259
111MP0001663_abnormal_digestive_system0.56022631
112MP0008874_decreased_physiological_sensi0.55627058
113MP0000015_abnormal_ear_pigmentation0.54095300
114MP0001348_abnormal_lacrimal_gland0.51859048
115MP0001881_abnormal_mammary_gland0.51435955
116MP0008438_abnormal_cutaneous_collagen0.49895122
117MP0009765_abnormal_xenobiotic_induced0.48624797
118MP0008057_abnormal_DNA_replication0.48201449
119MP0000627_abnormal_mammary_gland0.46806446
120MP0005621_abnormal_cell_physiology0.45791035
121MP0000313_abnormal_cell_death0.44576079

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.01464904
2Recurrent abscess formation (HP:0002722)5.67777577
3Recurrent bacterial skin infections (HP:0005406)5.28144171
4Chronic otitis media (HP:0000389)5.04114429
5Elevated erythrocyte sedimentation rate (HP:0003565)4.56275928
6Recurrent fungal infections (HP:0002841)4.51978114
7Recurrent viral infections (HP:0004429)4.41660834
8Autoimmune thrombocytopenia (HP:0001973)4.31175098
9Myositis (HP:0100614)4.24724173
10Recurrent bronchitis (HP:0002837)4.14961586
11Mediastinal lymphadenopathy (HP:0100721)4.13825897
12Recurrent gram-negative bacterial infections (HP:0005420)4.06049635
13Nasal polyposis (HP:0100582)4.02525302
14Abnormality of glycolipid metabolism (HP:0010969)3.96968176
15Abnormality of liposaccharide metabolism (HP:0010968)3.96968176
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.96968176
17Abnormality of macrophages (HP:0004311)3.84929240
18Recurrent skin infections (HP:0001581)3.82046252
19Recurrent cutaneous fungal infections (HP:0011370)3.72557819
20Chronic mucocutaneous candidiasis (HP:0002728)3.72557819
21Vasculitis (HP:0002633)3.65952296
22Abnormality of the nasal mucosa (HP:0000433)3.64641504
23Orchitis (HP:0100796)3.59125176
24Abnormality of T cell number (HP:0011839)3.55116546
25Pustule (HP:0200039)3.52860554
26T lymphocytopenia (HP:0005403)3.44073223
27Optic neuritis (HP:0100653)3.39334169
28Retrobulbar optic neuritis (HP:0100654)3.39334169
29Amyloidosis (HP:0011034)3.37722957
30Stomatitis (HP:0010280)3.35653782
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.35256162
32Chronic obstructive pulmonary disease (HP:0006510)3.31679805
33Obstructive lung disease (HP:0006536)3.31679805
34Cellulitis (HP:0100658)3.29651591
35Gingivitis (HP:0000230)3.20111594
36Increased IgM level (HP:0003496)3.16614017
37Spontaneous hematomas (HP:0007420)3.12931038
38Abnormality of T cells (HP:0002843)3.11851582
39Meningitis (HP:0001287)3.07612863
40IgM deficiency (HP:0002850)3.01318028
41Chronic sinusitis (HP:0011109)2.99087234
42Agammaglobulinemia (HP:0004432)2.98672962
43Interstitial pulmonary disease (HP:0006530)2.95112515
44Periodontitis (HP:0000704)2.94416721
45Inflammation of the large intestine (HP:0002037)2.91855396
46Increased IgE level (HP:0003212)2.87565136
47Pulmonary infiltrates (HP:0002113)2.87440659
48Colitis (HP:0002583)2.82950176
49Panhypogammaglobulinemia (HP:0003139)2.80200477
50Loss of speech (HP:0002371)2.77261982
51Hypergammaglobulinemia (HP:0010702)2.77131456
52Leukocytosis (HP:0001974)2.77028164
53Gastrointestinal inflammation (HP:0004386)2.76258361
54Abnormality of the fingertips (HP:0001211)2.74044359
55Eosinophilia (HP:0001880)2.73028054
56Abnormality of T cell physiology (HP:0011840)2.72565620
57Autoimmune hemolytic anemia (HP:0001890)2.71686171
58Emphysema (HP:0002097)2.70276405
59Systemic lupus erythematosus (HP:0002725)2.68191928
60Lymphopenia (HP:0001888)2.68080299
61Dysostosis multiplex (HP:0000943)2.66534914
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.65097636
63Gastrointestinal infarctions (HP:0005244)2.62775648
64Hemoptysis (HP:0002105)2.62002261
65Hematochezia (HP:0002573)2.59792751
66IgA deficiency (HP:0002720)2.59625891
67Gastrointestinal stroma tumor (HP:0100723)2.59293579
68Osteomyelitis (HP:0002754)2.58485662
69Pulmonary embolism (HP:0002204)2.57514307
70Vacuolated lymphocytes (HP:0001922)2.56606179
71Prolonged bleeding time (HP:0003010)2.51439626
72IgG deficiency (HP:0004315)2.48937041
73Arterial thrombosis (HP:0004420)2.46618362
74Osteolytic defects of the hand bones (HP:0009699)2.45961683
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.45961683
76Granulocytopenia (HP:0001913)2.43864721
77Gingival bleeding (HP:0000225)2.42782006
78Recurrent pneumonia (HP:0006532)2.40091932
79Increased cerebral lipofuscin (HP:0011813)2.39396419
80Recurrent lower respiratory tract infections (HP:0002783)2.36107197
81Abnormality of eosinophils (HP:0001879)2.35501587
82Purpura (HP:0000979)2.35101333
83Skin ulcer (HP:0200042)2.33595294
84Petechiae (HP:0000967)2.32727252
85Bronchitis (HP:0012387)2.29239626
86Urticaria (HP:0001025)2.28718502
87Peritonitis (HP:0002586)2.28690406
88Thick nail (HP:0001805)2.27491371
89Thrombocytosis (HP:0001894)2.24500768
90Gangrene (HP:0100758)2.24138311
91Encephalitis (HP:0002383)2.22847844
92Chronic diarrhea (HP:0002028)2.20487574
93Keratoconjunctivitis sicca (HP:0001097)2.20462446
94Anorexia (HP:0002039)2.19895248
95Myocardial infarction (HP:0001658)2.19394597
96Chest pain (HP:0100749)2.18089728
97Abnormality of the pleura (HP:0002103)2.16997838
98Combined immunodeficiency (HP:0005387)2.15935498
99Polyneuropathy (HP:0001271)2.14108815
100Amaurosis fugax (HP:0100576)2.13251119
101Cheilitis (HP:0100825)2.10639548
102Severe combined immunodeficiency (HP:0004430)2.10115735
103Recurrent sinusitis (HP:0011108)2.10025516
104Joint swelling (HP:0001386)2.09942500
105Glomerulopathy (HP:0100820)2.08731504
106Increased neuronal autofluorescent lipopigment (HP:0002074)2.07672281
107Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07253328
108Verrucae (HP:0200043)2.05906358
109Papilloma (HP:0012740)2.05906358
110Thyroiditis (HP:0100646)2.05301808
111Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04969266
112Abnormality of polysaccharide metabolism (HP:0011012)2.04969266
113Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04969266
114Mucopolysacchariduria (HP:0008155)2.04161184
115Urinary glycosaminoglycan excretion (HP:0003541)2.04161184
116Vertigo (HP:0002321)2.04121929
117Disinhibition (HP:0000734)2.02696545
118Keratoconjunctivitis (HP:0001096)2.00515656
119Episodic fever (HP:0001954)1.99564957
120* Basal ganglia calcification (HP:0002135)1.96893382
121Epistaxis (HP:0000421)1.96740223
122Abnormality of the vasculature of the conjunctiva (HP:0008054)1.96617243
123Arthralgia (HP:0002829)1.95929213
124Malnutrition (HP:0004395)1.95614294
125Abnormality of the peritoneum (HP:0002585)1.94432979
126Prostate neoplasm (HP:0100787)1.94303319
127Increased serum ferritin (HP:0003281)1.93910678
128B lymphocytopenia (HP:0010976)1.93836806
129Thrombophlebitis (HP:0004418)1.90669395
130Abnormality of the prostate (HP:0008775)1.88815809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.40866673
2TYK23.88275167
3MAP3K143.42006189
4JAK33.27327799
5BLK3.09630825
6IKBKE3.03550042
7TBK12.93419041
8TXK2.70460462
9IRAK42.62892458
10JAK12.57165381
11PRPF4B2.53503951
12FGFR42.51224452
13KIT2.45540341
14IKBKB2.14276136
15STK102.14225063
16ZAP702.12133252
17IRAK32.03790665
18MAP3K131.97484103
19FGFR31.91745090
20ERN11.91639724
21RIPK41.89192472
22CSK1.73727027
23SYK1.56842394
24ITK1.52501899
25EPHB11.50018163
26BTK1.50005984
27HCK1.45136162
28LCK1.42626286
29CHUK1.34168807
30MAP3K101.32850919
31CSF1R1.32838212
32RPS6KA41.32266703
33TNK21.30172616
34TEC1.26097725
35GRK61.23394490
36TGFBR21.23239018
37EPHA31.21514132
38PIM21.19916943
39LRRK21.16296319
40GRK71.14451724
41CAMKK21.12017707
42PIM11.11802778
43PIK3CG1.11588413
44JAK21.09057920
45CDK121.08322539
46NEK91.06326837
47MST41.06062800
48NME21.05514655
49TAOK11.04689125
50MARK31.02978542
51MAP2K31.00019632
52NLK0.99914696
53LYN0.99224085
54MAP3K10.98589495
55CDC42BPA0.97749924
56PBK0.96129242
57TRIB30.93105507
58TTN0.91074547
59YES10.89162161
60PDPK10.87335299
61CDK190.86446739
62STK40.81897971
63IRAK10.81353939
64MARK20.80994279
65TAOK30.80781290
66FES0.80554951
67PRKCQ0.79674949
68KSR20.78757912
69MAPK70.77952425
70CLK10.74230393
71MAP3K20.70845502
72MAPK120.70769918
73STK30.70011039
74SIK20.69804954
75TAOK20.68447195
76PTK60.65531461
77STK240.65124048
78SGK30.64190488
79MAP3K60.62744182
80CAMKK10.60982833
81BMPR20.60584450
82TRPM70.60151060
83KDR0.60078687
84CDK60.59838983
85FGR0.57194350
86PKN20.56341200
87EGFR0.52817239
88ALK0.51149043
89MOS0.50514110
90ABL10.49398797
91SGK20.48668062
92PRKCH0.48312856
93CDK40.47794640
94MAP3K50.45157926
95MAP3K30.45125514
96PTK2B0.44495249
97RPS6KL10.43963087
98RPS6KC10.43963087
99BMX0.43757980
100EEF2K0.43668898
101RPS6KA50.41120239
102SIK30.40599315
103DMPK0.40148289
104MATK0.39702656
105MAP3K70.39078377
106EIF2AK20.37943443
107MAP3K80.37870959
108NUAK10.37447316
109FLT30.35536656
110PRKD20.34411755
111RIPK10.34404248
112MAPKAPK20.33779934
113RET0.33521314
114PRKCD0.33509682
115ACVR1B0.33286058
116STK110.32721048
117NEK60.32629029
118CAMK40.32421919
119BRD40.32309773
120HIPK20.30834744
121PDGFRB0.30569251
122CAMK1D0.29687560
123RPS6KA60.28888899
124PDK10.26385894
125CDK90.25712451
126FYN0.25532572
127MAPK110.25456143
128INSR0.25268132
129IRAK20.25102910
130MAP3K110.23913298
131NEK20.19356982
132IGF1R0.18572251

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.01183597
2Leishmaniasis_Homo sapiens_hsa051402.94623499
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.85955814
4Measles_Homo sapiens_hsa051622.61762168
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.56366759
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.51446470
7Allograft rejection_Homo sapiens_hsa053302.49416385
8Osteoclast differentiation_Homo sapiens_hsa043802.37527909
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.31440291
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31128112
11Graft-versus-host disease_Homo sapiens_hsa053322.28236471
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.27217980
13B cell receptor signaling pathway_Homo sapiens_hsa046622.16360966
14Antigen processing and presentation_Homo sapiens_hsa046122.09783949
15Staphylococcus aureus infection_Homo sapiens_hsa051502.04528482
16Herpes simplex infection_Homo sapiens_hsa051681.99741881
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.96738009
18Influenza A_Homo sapiens_hsa051641.91258126
19Toxoplasmosis_Homo sapiens_hsa051451.81269668
20T cell receptor signaling pathway_Homo sapiens_hsa046601.79477451
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76448639
22Tuberculosis_Homo sapiens_hsa051521.74224024
23Pertussis_Homo sapiens_hsa051331.73410131
24TNF signaling pathway_Homo sapiens_hsa046681.70220283
25Hematopoietic cell lineage_Homo sapiens_hsa046401.68839609
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.68578047
27Malaria_Homo sapiens_hsa051441.67496249
28Legionellosis_Homo sapiens_hsa051341.63091378
29Viral myocarditis_Homo sapiens_hsa054161.62505013
30Autoimmune thyroid disease_Homo sapiens_hsa053201.57036800
31Chemokine signaling pathway_Homo sapiens_hsa040621.51704950
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50992482
33Apoptosis_Homo sapiens_hsa042101.48667540
34Hepatitis B_Homo sapiens_hsa051611.42597842
35Shigellosis_Homo sapiens_hsa051311.41956946
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41460723
37Asthma_Homo sapiens_hsa053101.40027012
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28003188
39Hepatitis C_Homo sapiens_hsa051601.27566052
40Acute myeloid leukemia_Homo sapiens_hsa052211.19909139
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.19240628
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17741137
43Salmonella infection_Homo sapiens_hsa051321.17697021
44Type I diabetes mellitus_Homo sapiens_hsa049401.15929828
45Rheumatoid arthritis_Homo sapiens_hsa053231.14971033
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11994025
47Chronic myeloid leukemia_Homo sapiens_hsa052201.05998924
48Pancreatic cancer_Homo sapiens_hsa052121.03833420
49African trypanosomiasis_Homo sapiens_hsa051431.00017713
50Epstein-Barr virus infection_Homo sapiens_hsa051690.97384166
51Lysosome_Homo sapiens_hsa041420.95285752
52Prolactin signaling pathway_Homo sapiens_hsa049170.91654889
53Small cell lung cancer_Homo sapiens_hsa052220.86577318
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85406105
55Platelet activation_Homo sapiens_hsa046110.85307992
56Viral carcinogenesis_Homo sapiens_hsa052030.83862181
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.81814668
58Phagosome_Homo sapiens_hsa041450.80897942
59Other glycan degradation_Homo sapiens_hsa005110.78034039
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76931956
61HTLV-I infection_Homo sapiens_hsa051660.74321774
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74297573
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73139439
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.72088735
65Caffeine metabolism_Homo sapiens_hsa002320.62705593
66p53 signaling pathway_Homo sapiens_hsa041150.60744960
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57972428
68Amoebiasis_Homo sapiens_hsa051460.57966752
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57755984
70Notch signaling pathway_Homo sapiens_hsa043300.56040975
71HIF-1 signaling pathway_Homo sapiens_hsa040660.52960247
72VEGF signaling pathway_Homo sapiens_hsa043700.52303356
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.51483639
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50253214
75Complement and coagulation cascades_Homo sapiens_hsa046100.49984920
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.47882249
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47526857
78MicroRNAs in cancer_Homo sapiens_hsa052060.46781427
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45799744
80GnRH signaling pathway_Homo sapiens_hsa049120.45082329
81Proteoglycans in cancer_Homo sapiens_hsa052050.43997898
82Non-small cell lung cancer_Homo sapiens_hsa052230.41428646
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40335212
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40169950
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.39698415
86FoxO signaling pathway_Homo sapiens_hsa040680.39332765
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39077954
88Choline metabolism in cancer_Homo sapiens_hsa052310.38589172
89Colorectal cancer_Homo sapiens_hsa052100.38273721
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37574745
91Endocytosis_Homo sapiens_hsa041440.36690542
92Insulin resistance_Homo sapiens_hsa049310.35172307
93Prostate cancer_Homo sapiens_hsa052150.32774143
94Endometrial cancer_Homo sapiens_hsa052130.31709584
95Type II diabetes mellitus_Homo sapiens_hsa049300.30461415
96Renal cell carcinoma_Homo sapiens_hsa052110.29549793
97Pathways in cancer_Homo sapiens_hsa052000.28145227
98MAPK signaling pathway_Homo sapiens_hsa040100.27538489
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27439719
100Non-homologous end-joining_Homo sapiens_hsa034500.25783548
101Collecting duct acid secretion_Homo sapiens_hsa049660.24945406
102Adherens junction_Homo sapiens_hsa045200.24794631
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.24728679
104Focal adhesion_Homo sapiens_hsa045100.23621437
105Base excision repair_Homo sapiens_hsa034100.23547106
106Systemic lupus erythematosus_Homo sapiens_hsa053220.23485835
107Estrogen signaling pathway_Homo sapiens_hsa049150.22450864
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21347583
109Dorso-ventral axis formation_Homo sapiens_hsa043200.20245224
110mTOR signaling pathway_Homo sapiens_hsa041500.19082597
111Inositol phosphate metabolism_Homo sapiens_hsa005620.17341037
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16073522
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15422158
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14226065

Most similar genes based on co-expression Upload to Enrichr

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