SAMM50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.39246777
2transcription from mitochondrial promoter (GO:0006390)8.25173508
3embryonic process involved in female pregnancy (GO:0060136)7.21003227
4replication fork processing (GO:0031297)6.64365921
5DNA deamination (GO:0045006)6.48898072
6positive regulation of protein homooligomerization (GO:0032464)6.28614412
7establishment of apical/basal cell polarity (GO:0035089)6.07527647
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.91889849
9regulation of integrin activation (GO:0033623)5.85491794
10oxidative demethylation (GO:0070989)5.80208789
11regulation of protein homooligomerization (GO:0032462)5.59431510
12mitochondrial DNA metabolic process (GO:0032042)5.53567010
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.51258760
14establishment of monopolar cell polarity (GO:0061162)5.19639720
15establishment or maintenance of monopolar cell polarity (GO:0061339)5.19639720
16mitotic G1 DNA damage checkpoint (GO:0031571)5.13013333
17energy coupled proton transport, down electrochemical gradient (GO:0015985)5.11530997
18ATP synthesis coupled proton transport (GO:0015986)5.11530997
19somatic hypermutation of immunoglobulin genes (GO:0016446)5.09053853
20somatic diversification of immune receptors via somatic mutation (GO:0002566)5.09053853
21negative regulation of fatty acid biosynthetic process (GO:0045717)5.01397342
22regulation of translational fidelity (GO:0006450)4.91220595
23glutamine family amino acid biosynthetic process (GO:0009084)4.82880307
24DNA strand renaturation (GO:0000733)4.59435836
25* establishment of protein localization to mitochondrial membrane (GO:0090151)4.57573446
26embryonic placenta development (GO:0001892)4.53551474
27ribosomal small subunit assembly (GO:0000028)4.52086208
28mitotic G1/S transition checkpoint (GO:0044819)4.51585001
29chaperone-mediated protein transport (GO:0072321)4.45867254
30formation of translation preinitiation complex (GO:0001731)4.44392730
31G1 DNA damage checkpoint (GO:0044783)4.40353302
32viral mRNA export from host cell nucleus (GO:0046784)4.35848394
33ribosomal small subunit biogenesis (GO:0042274)4.32549180
34mRNA cleavage (GO:0006379)4.25228119
35negative regulation of JAK-STAT cascade (GO:0046426)4.22834822
36poly(A)+ mRNA export from nucleus (GO:0016973)4.22166694
37cellular response to zinc ion (GO:0071294)4.19644259
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.19547611
39proteasome assembly (GO:0043248)4.15726912
40respiratory electron transport chain (GO:0022904)4.13324488
41viral transcription (GO:0019083)4.11755977
42negative regulation of cell cycle arrest (GO:0071157)4.11568804
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.10192582
44spliceosomal tri-snRNP complex assembly (GO:0000244)4.08784057
45electron transport chain (GO:0022900)4.02702949
46translational termination (GO:0006415)4.01807561
47mitochondrial RNA metabolic process (GO:0000959)3.99910597
48sulfur amino acid catabolic process (GO:0000098)3.97041315
49base-excision repair (GO:0006284)3.93691804
50telomere maintenance via semi-conservative replication (GO:0032201)3.89899442
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.89836783
52rRNA modification (GO:0000154)3.89667144
53ribosomal large subunit biogenesis (GO:0042273)3.88701488
54positive regulation of protein oligomerization (GO:0032461)3.87075321
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.86115423
56maturation of SSU-rRNA (GO:0030490)3.81395787
57cotranslational protein targeting to membrane (GO:0006613)3.80038826
58cellular response to ATP (GO:0071318)3.79204239
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.76020174
60mitochondrial respiratory chain complex I assembly (GO:0032981)3.76020174
61NADH dehydrogenase complex assembly (GO:0010257)3.76020174
62protein targeting to ER (GO:0045047)3.75320743
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74225662
64negative regulation of protein oligomerization (GO:0032460)3.72591561
65apoptotic process involved in morphogenesis (GO:0060561)3.69541578
66mitochondrial respiratory chain complex assembly (GO:0033108)3.68567155
67translational elongation (GO:0006414)3.67678494
68protein complex biogenesis (GO:0070271)3.66808262
69establishment of protein localization to endoplasmic reticulum (GO:0072599)3.60188190
70regulation of protein oligomerization (GO:0032459)3.59136054
71positive regulation of developmental pigmentation (GO:0048087)3.58813052
72protein localization to endoplasmic reticulum (GO:0070972)3.58296983
73tricarboxylic acid cycle (GO:0006099)3.57659825
74translation (GO:0006412)3.54036892
75double-strand break repair via nonhomologous end joining (GO:0006303)3.52318830
76non-recombinational repair (GO:0000726)3.52318830
77dosage compensation (GO:0007549)3.50120174
78IMP metabolic process (GO:0046040)3.49694639
79translational initiation (GO:0006413)3.49475283
80DNA damage response, detection of DNA damage (GO:0042769)3.48801380
81inner mitochondrial membrane organization (GO:0007007)3.48768581
82negative regulation of Ras GTPase activity (GO:0034261)3.48655736
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.48554658
84DNA integration (GO:0015074)3.47648555
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.46899174
86cullin deneddylation (GO:0010388)3.46240968
87peptidyl-histidine modification (GO:0018202)3.44607134
88negative regulation of mRNA processing (GO:0050686)3.43131993
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.42069427
90negative regulation of ligase activity (GO:0051352)3.40666579
91negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40666579
92establishment of integrated proviral latency (GO:0075713)3.39195673
93positive regulation by host of viral transcription (GO:0043923)3.38595347
94IMP biosynthetic process (GO:0006188)3.38401413
95ribonucleoprotein complex biogenesis (GO:0022613)3.38145564
96cellular component biogenesis (GO:0044085)3.37416968
97nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.31124673
98positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.31007120
99positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.31007120
100positive regulation of mitotic sister chromatid separation (GO:1901970)3.31007120
101embryonic camera-type eye development (GO:0031076)3.29292800
102protein deneddylation (GO:0000338)3.29243712
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29098360
104aerobic respiration (GO:0009060)3.29056314
105termination of RNA polymerase III transcription (GO:0006386)3.28466905
106transcription elongation from RNA polymerase III promoter (GO:0006385)3.28466905
107base-excision repair, AP site formation (GO:0006285)3.27742305
108actin-myosin filament sliding (GO:0033275)3.26981522
109muscle filament sliding (GO:0030049)3.26981522
110trophectodermal cell differentiation (GO:0001829)3.26843777
111convergent extension (GO:0060026)3.26242121
112regulation of gene silencing by RNA (GO:0060966)3.26062317
113regulation of posttranscriptional gene silencing (GO:0060147)3.26062317
114regulation of gene silencing by miRNA (GO:0060964)3.26062317
115purine nucleobase biosynthetic process (GO:0009113)3.25611893
116histone H4-K12 acetylation (GO:0043983)3.22491139
117regulation of cellular amino acid metabolic process (GO:0006521)3.22475010
118regulation of sister chromatid cohesion (GO:0007063)3.21983422
119viral life cycle (GO:0019058)3.21982646
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21644675
121ATP biosynthetic process (GO:0006754)3.21005312
122alkaloid metabolic process (GO:0009820)3.20418954
123* protein targeting to mitochondrion (GO:0006626)3.20335692
124pseudouridine synthesis (GO:0001522)3.18906192
125labyrinthine layer development (GO:0060711)3.18699658
126DNA strand elongation involved in DNA replication (GO:0006271)3.18134622
127DNA topological change (GO:0006265)3.17800285
128GDP-mannose metabolic process (GO:0019673)3.16824316
129negative regulation of fatty acid metabolic process (GO:0045922)3.16692884
130DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16418924
131regulation of mitochondrial translation (GO:0070129)3.16402767
132protein neddylation (GO:0045116)3.15977234
133nucleobase biosynthetic process (GO:0046112)3.15589940
134anatomical structure regression (GO:0060033)3.15286144
135termination of RNA polymerase II transcription (GO:0006369)3.14697226
136chromatin remodeling at centromere (GO:0031055)3.13977673
137signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.12468997
138signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.12468997
139signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.12468997
140intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12238106
141signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12238106
142nodal signaling pathway (GO:0038092)3.11833876
143purine nucleoside monophosphate biosynthetic process (GO:0009127)3.11720819
144purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.11720819
145rRNA methylation (GO:0031167)3.10677941
146regulation of RNA export from nucleus (GO:0046831)3.09937174
147mitochondrial fusion (GO:0008053)3.07895477
148oxidative phosphorylation (GO:0006119)3.07731282
149CENP-A containing nucleosome assembly (GO:0034080)3.06890210
150cellular protein complex disassembly (GO:0043624)3.06802161
151spliceosomal snRNP assembly (GO:0000387)3.05759705
152tRNA aminoacylation for protein translation (GO:0006418)3.05693404
153glial cell migration (GO:0008347)3.05603984
154signal transduction involved in DNA damage checkpoint (GO:0072422)3.05277131
155signal transduction involved in DNA integrity checkpoint (GO:0072401)3.05277131
156ubiquinone biosynthetic process (GO:0006744)3.04026178
157telomere maintenance via recombination (GO:0000722)3.02713079
158purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02490422
159signal transduction involved in cell cycle checkpoint (GO:0072395)3.01806836
160purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01508122
161mitochondrial DNA replication (GO:0006264)3.00922549
162rRNA processing (GO:0006364)3.00679355
163* protein localization to mitochondrion (GO:0070585)3.00177044
164amino acid activation (GO:0043038)3.00051414
165tRNA aminoacylation (GO:0043039)3.00051414
166NADH metabolic process (GO:0006734)2.99965254
167maturation of 5.8S rRNA (GO:0000460)2.98029364
168negative regulation of RNA splicing (GO:0033119)2.97321197
169* establishment of protein localization to mitochondrion (GO:0072655)2.96912000
170DNA double-strand break processing (GO:0000729)2.96772764
171face development (GO:0060324)2.95455233
172regulation of cell size (GO:0008361)2.95182884
173DNA strand elongation (GO:0022616)2.95043684
174ribosome biogenesis (GO:0042254)2.94662163
175meiotic chromosome segregation (GO:0045132)2.94598519
176positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93988599
177L-serine metabolic process (GO:0006563)2.93580768
178positive regulation of DNA repair (GO:0045739)2.93246338
179nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93182430
180ubiquinone metabolic process (GO:0006743)2.92525768
181very-low-density lipoprotein particle assembly (GO:0034379)2.91794673
182ribonucleoside triphosphate biosynthetic process (GO:0009201)2.90265472
183regulation of double-strand break repair via homologous recombination (GO:0010569)2.89160209
184determination of adult lifespan (GO:0008340)2.82718045
185DNA demethylation (GO:0080111)2.80086099
186nuclear envelope reassembly (GO:0031468)2.79977668
187mitotic nuclear envelope reassembly (GO:0007084)2.79977668
188hypotonic response (GO:0006971)2.79319438
189regulation of DNA damage checkpoint (GO:2000001)2.79054449
190negative regulation of heart rate (GO:0010459)2.77153082
191DNA ligation (GO:0006266)2.76741649
192regulation of double-strand break repair (GO:2000779)2.75822325
193proline biosynthetic process (GO:0006561)10.9000306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.89593921
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.60242073
3* GABP_17652178_ChIP-ChIP_JURKAT_Human4.20727180
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.91268738
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.58447135
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.51010336
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.07150574
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89581197
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88632571
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.86251773
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.83985547
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.83201037
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75238985
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67647385
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.65361224
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.65361224
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.65361224
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48446037
19VDR_21846776_ChIP-Seq_THP-1_Human2.42453677
20E2F7_22180533_ChIP-Seq_HELA_Human2.42329254
21FOXP3_21729870_ChIP-Seq_TREG_Human2.29015301
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.28808788
23* VDR_23849224_ChIP-Seq_CD4+_Human2.27897024
24ELK1_19687146_ChIP-ChIP_HELA_Human2.27027230
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22135835
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.19451568
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18621505
28TTF2_22483619_ChIP-Seq_HELA_Human2.17783801
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.14231362
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.13127334
31STAT3_1855785_ChIP-Seq_MESCs_Mouse2.10740775
32MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07555115
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.05056057
34LXR_22292898_ChIP-Seq_THP-1_Human2.03030816
35* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.02769107
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00291157
37* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.99547138
38* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.97821299
39* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.91439331
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88689922
41POU5F1_16518401_ChIP-PET_MESCs_Mouse1.87980361
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87067562
43ZNF263_19887448_ChIP-Seq_K562_Human1.81060556
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.80558982
45MYC_22102868_ChIP-Seq_BL_Human1.78463227
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.75947798
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75350187
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74654322
49TCF3_18692474_ChIP-Seq_MESCs_Mouse1.73038812
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.68470190
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67475996
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62699536
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.61477433
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59456401
55* RXR_22158963_ChIP-Seq_LIVER_Mouse1.58194901
56* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58184523
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58141414
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57692887
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55767062
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55640754
61* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.54601184
62NANOG_21062744_ChIP-ChIP_HESCs_Human1.54243504
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.54231388
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.53457537
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51034914
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.50807239
67RACK7_27058665_Chip-Seq_MCF-7_Human1.50251773
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48339966
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48190717
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47761544
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45675521
72* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44393885
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40800600
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39336078
75* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39139290
76* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37327314
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36672845
78MYC_18940864_ChIP-ChIP_HL60_Human1.35751545
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34961392
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33940724
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33266848
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32296567
83THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31784017
84* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29384584
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29178361
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.28496134
87* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26949920
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26485964
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25995510
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25288159
91KDM2B_26808549_Chip-Seq_DND41_Human1.24670527
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.23780466
93* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.23723102
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23154820
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22814870
96RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22750918
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22667906
98OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22165865
99* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20942968
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20759052
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20302346
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.19874907
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19779783
104NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19629650
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19560353
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19401122
107* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18925581
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18820046
109ETS1_20019798_ChIP-Seq_JURKAT_Human1.17498529
110CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16874631
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15944496
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15421795
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15411999
114ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14589701
115ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14298107
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13819593
117RARB_24833708_ChIP-Seq_LIVER_Mouse1.13805442
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13716973
119* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13703494
120AR_21909140_ChIP-Seq_LNCAP_Human1.13513916
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12809373
122* ETS1_21867929_ChIP-Seq_TH2_Mouse1.11769708
123* GABP_19822575_ChIP-Seq_HepG2_Human1.11644713
124* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11196574
125DCP1A_22483619_ChIP-Seq_HELA_Human1.10782810
126SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08974340
127SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08600725
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08593374
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07568484
130* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07365753
131* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06392972
132XRN2_22483619_ChIP-Seq_HELA_Human1.06097703
133SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05430730
134RARA_24833708_ChIP-Seq_LIVER_Mouse1.05197784
135CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05159519
136KDM5A_27292631_Chip-Seq_BREAST_Human1.05146390
137PHF8_20622854_ChIP-Seq_HELA_Human1.05120545
138CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02914439
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02895389
140GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02698770
141KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02391233
142CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02210052
143* BCOR_27268052_Chip-Seq_Bcells_Human1.02069249
144CIITA_25753668_ChIP-Seq_RAJI_Human1.01819778
145NANOG_16153702_ChIP-ChIP_HESCs_Human1.01655646
146* SOX17_20123909_ChIP-Seq_XEN_Mouse0.99649192
147ELK1_22589737_ChIP-Seq_MCF10A_Human0.95563354
148FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91731719
149CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91164007
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89870059
151TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87880111
152SOX2_16153702_ChIP-ChIP_HESCs_Human0.87013048
153TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86416957
154FOXP1_21924763_ChIP-Seq_HESCs_Human0.85025206
155CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82399317
156SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79931080
157HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.77951992
158GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75735626
159CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74866530
160SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74740044
161CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74721892
162BP1_19119308_ChIP-ChIP_Hs578T_Human0.73443650
163TFEB_21752829_ChIP-Seq_HELA_Human0.67736182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.54669423
2MP0009278_abnormal_bone_marrow4.15848612
3MP0004233_abnormal_muscle_weight3.63080937
4MP0000372_irregular_coat_pigmentation3.56784141
5MP0005171_absent_coat_pigmentation3.56461193
6MP0004145_abnormal_muscle_electrophysio3.47949638
7MP0010030_abnormal_orbit_morphology3.38681126
8MP0003646_muscle_fatigue3.28468543
9MP0000749_muscle_degeneration2.93725518
10MP0008789_abnormal_olfactory_epithelium2.63042603
11MP0002009_preneoplasia2.59125515
12MP0003186_abnormal_redox_activity2.49724540
13MP0005085_abnormal_gallbladder_physiolo2.32999321
14MP0004147_increased_porphyrin_level2.32001660
15MP0009379_abnormal_foot_pigmentation2.30730446
16MP0003283_abnormal_digestive_organ2.29555949
17MP0002938_white_spotting2.23866733
18MP0010094_abnormal_chromosome_stability2.19968439
19MP0002837_dystrophic_cardiac_calcinosis2.17400051
20MP0005397_hematopoietic_system_phenotyp2.10314373
21MP0001545_abnormal_hematopoietic_system2.10314373
22MP0002102_abnormal_ear_morphology2.08707437
23MP0008995_early_reproductive_senescence2.06771730
24MP0005365_abnormal_bile_salt2.05808989
25MP0004133_heterotaxia2.02306640
26MP0004957_abnormal_blastocyst_morpholog2.01799050
27MP0002269_muscular_atrophy1.96448536
28MP0001529_abnormal_vocalization1.93644121
29MP0003890_abnormal_embryonic-extraembry1.92199940
30MP0005394_taste/olfaction_phenotype1.89372216
31MP0005499_abnormal_olfactory_system1.89372216
32MP0010352_gastrointestinal_tract_polyps1.88393617
33MP0003806_abnormal_nucleotide_metabolis1.87903543
34MP0006035_abnormal_mitochondrial_morpho1.86086793
35MP0002653_abnormal_ependyma_morphology1.82202490
36MP0006292_abnormal_olfactory_placode1.79620046
37MP0003136_yellow_coat_color1.78079420
38MP0003453_abnormal_keratinocyte_physiol1.73405172
39MP0003119_abnormal_digestive_system1.73376996
40MP0008007_abnormal_cellular_replicative1.70139975
41MP0005076_abnormal_cell_differentiation1.65343375
42MP0002086_abnormal_extraembryonic_tissu1.63931668
43MP0005330_cardiomyopathy1.63454442
44MP0006072_abnormal_retinal_apoptosis1.62829132
45MP0003786_premature_aging1.62025819
46MP0003567_abnormal_fetal_cardiomyocyte1.58943957
47MP0002249_abnormal_larynx_morphology1.56242453
48MP0001697_abnormal_embryo_size1.52194529
49MP0005408_hypopigmentation1.49813363
50MP0009697_abnormal_copulation1.49466104
51MP0000759_abnormal_skeletal_muscle1.48375872
52MP0002084_abnormal_developmental_patter1.48068637
53MP0005174_abnormal_tail_pigmentation1.47552969
54MP0004036_abnormal_muscle_relaxation1.45909774
55MP0004197_abnormal_fetal_growth/weight/1.45171826
56MP0003111_abnormal_nucleus_morphology1.43941366
57MP0000371_diluted_coat_color1.43688956
58MP0002282_abnormal_trachea_morphology1.43643955
59MP0000490_abnormal_crypts_of1.40568695
60MP0005058_abnormal_lysosome_morphology1.37985846
61MP0000579_abnormal_nail_morphology1.36554677
62MP0004215_abnormal_myocardial_fiber1.36215631
63MP0001293_anophthalmia1.36131305
64MP0003172_abnormal_lysosome_physiology1.34869860
65MP0003705_abnormal_hypodermis_morpholog1.33826498
66MP0005266_abnormal_metabolism1.33571707
67MP0002085_abnormal_embryonic_tissue1.32151585
68MP0001672_abnormal_embryogenesis/_devel1.26170695
69MP0005380_embryogenesis_phenotype1.26170695
70MP0008932_abnormal_embryonic_tissue1.26019398
71MP0002796_impaired_skin_barrier1.24965957
72MP0000751_myopathy1.24769790
73MP0008058_abnormal_DNA_repair1.23685414
74MP0003137_abnormal_impulse_conducting1.19485053
75MP0010630_abnormal_cardiac_muscle1.18699766
76MP0005670_abnormal_white_adipose1.18323877
77MP0001730_embryonic_growth_arrest1.17883375
78MP0004084_abnormal_cardiac_muscle1.17364947
79MP0003077_abnormal_cell_cycle1.15115906
80MP0001661_extended_life_span1.14758112
81MP0000358_abnormal_cell_content/1.14614801
82MP0005369_muscle_phenotype1.13287447
83MP0003828_pulmonary_edema1.12829631
84MP0000470_abnormal_stomach_morphology1.12813490
85MP0003878_abnormal_ear_physiology1.11536673
86MP0005377_hearing/vestibular/ear_phenot1.11536673
87MP0003941_abnormal_skin_development1.11402462
88MP0002638_abnormal_pupillary_reflex1.10933954
89MP0003656_abnormal_erythrocyte_physiolo1.09977927
90MP0000639_abnormal_adrenal_gland1.09549819
91MP0005620_abnormal_muscle_contractility1.06411267
92MP0005075_abnormal_melanosome_morpholog1.06137794
93MP0005360_urolithiasis1.05916520
94MP0002332_abnormal_exercise_endurance1.05204726
95MP0003693_abnormal_embryo_hatching1.04610511
96MP0001984_abnormal_olfaction1.04373232
97MP0004130_abnormal_muscle_cell1.04105849
98MP0002080_prenatal_lethality1.04102208
99MP0000350_abnormal_cell_proliferation1.03776565
100MP0000750_abnormal_muscle_regeneration1.03599116
101MP0003984_embryonic_growth_retardation1.03073276
102MP0009115_abnormal_fat_cell1.02542119
103MP0004185_abnormal_adipocyte_glucose1.01618861
104MP0002019_abnormal_tumor_incidence1.01219594
105MP0006036_abnormal_mitochondrial_physio0.98724150
106MP0002088_abnormal_embryonic_growth/wei0.98647337
107MP0002111_abnormal_tail_morphology0.98056029
108MP0004264_abnormal_extraembryonic_tissu0.97736087
109MP0002163_abnormal_gland_morphology0.97650914
110MP0009672_abnormal_birth_weight0.96423933
111MP0008877_abnormal_DNA_methylation0.95636600
112MP0002972_abnormal_cardiac_muscle0.95587842
113MP0004087_abnormal_muscle_fiber0.94606653
114MP0000462_abnormal_digestive_system0.94259540
115MP0003221_abnormal_cardiomyocyte_apopto0.90991398
116MP0005084_abnormal_gallbladder_morpholo0.90786035
117MP0003011_delayed_dark_adaptation0.88702721
118MP0003315_abnormal_perineum_morphology0.87645834
119MP0005501_abnormal_skin_physiology0.86240841
120MP0002970_abnormal_white_adipose0.85774351
121MP0008775_abnormal_heart_ventricle0.85299546
122MP0001340_abnormal_eyelid_morphology0.85149438
123MP0003566_abnormal_cell_adhesion0.83629569
124MP0002139_abnormal_hepatobiliary_system0.83272116
125MP0004019_abnormal_vitamin_homeostasis0.82915813
126MP0004142_abnormal_muscle_tone0.82837889
127MP0002233_abnormal_nose_morphology0.82292775
128MP0010307_abnormal_tumor_latency0.82158431
129MP0002060_abnormal_skin_morphology0.80774083
130MP0002822_catalepsy0.79933244
131MP0002075_abnormal_coat/hair_pigmentati0.79279606
132MP0002234_abnormal_pharynx_morphology0.79065983
133MP0002160_abnormal_reproductive_system0.78840869
134MP0002971_abnormal_brown_adipose0.77842778
135MP0002210_abnormal_sex_determination0.77068484
136MP0003718_maternal_effect0.76196575
137MP0002932_abnormal_joint_morphology0.76186410
138MP0002106_abnormal_muscle_physiology0.76128238
139MP0000762_abnormal_tongue_morphology0.75716492
140MP0001286_abnormal_eye_development0.75596326
141MP0005023_abnormal_wound_healing0.75204340
142MP0003937_abnormal_limbs/digits/tail_de0.74969223
143MP0003121_genomic_imprinting0.74684989
144MP0002095_abnormal_skin_pigmentation0.74478466
145MP0000049_abnormal_middle_ear0.74344896
146MP0009053_abnormal_anal_canal0.73785430
147MP0005332_abnormal_amino_acid0.73060967
148MP0002697_abnormal_eye_size0.72789615
149MP0001346_abnormal_lacrimal_gland0.72281754
150MP0005666_abnormal_adipose_tissue0.72219394
151MP0000609_abnormal_liver_physiology0.71371460
152MP0000313_abnormal_cell_death0.70913814
153MP0002736_abnormal_nociception_after0.70528621
154MP0000685_abnormal_immune_system0.70419623
155MP0005319_abnormal_enzyme/_coenzyme0.70068006
156MP0000747_muscle_weakness0.69662126
157MP0001485_abnormal_pinna_reflex0.69271543
158MP0002127_abnormal_cardiovascular_syste0.68874121

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)5.20180867
2Muscle fiber inclusion bodies (HP:0100299)5.14092359
3Rib fusion (HP:0000902)5.08454024
4Pustule (HP:0200039)5.06461031
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.91688323
6Annular pancreas (HP:0001734)4.80232289
7Acute necrotizing encephalopathy (HP:0006965)4.72069517
8Concave nail (HP:0001598)4.69602867
9Turricephaly (HP:0000262)4.61924725
10Alopecia of scalp (HP:0002293)4.57461312
11Rectovaginal fistula (HP:0000143)4.52462190
12Rectal fistula (HP:0100590)4.52462190
13Facial hemangioma (HP:0000329)4.51699307
14Abnormal mitochondria in muscle tissue (HP:0008316)4.49096808
15Exercise-induced muscle cramps (HP:0003710)4.46484816
16Acute encephalopathy (HP:0006846)4.36291539
17Poikiloderma (HP:0001029)4.33495757
18Hypochromic microcytic anemia (HP:0004840)4.25541663
19Increased IgM level (HP:0003496)4.25376203
20Vaginal fistula (HP:0004320)4.18445836
21Ulnar bowing (HP:0003031)4.17946362
22Intestinal fistula (HP:0100819)4.00413274
23Mitochondrial inheritance (HP:0001427)3.96985056
24Abnormal hemoglobin (HP:0011902)3.95095557
25Increased CSF lactate (HP:0002490)3.77353475
26Tongue fasciculations (HP:0001308)3.73911842
27Hepatocellular necrosis (HP:0001404)3.71572766
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.71539878
29Increased serum pyruvate (HP:0003542)3.69791071
30Muscle fibrillation (HP:0010546)3.63570495
31Progressive macrocephaly (HP:0004481)3.63494402
32Hepatic necrosis (HP:0002605)3.56762048
33Short humerus (HP:0005792)3.56294094
34Abnormality of glycolysis (HP:0004366)3.53982730
35Coronal craniosynostosis (HP:0004440)3.46123549
36Aplasia/hypoplasia of the humerus (HP:0006507)3.44045284
37Male infertility (HP:0003251)3.40459875
38Cerebral edema (HP:0002181)3.37880568
39Increased intramyocellular lipid droplets (HP:0012240)3.35589263
40Orthostatic hypotension (HP:0001278)3.35442201
41Rhabdomyolysis (HP:0003201)3.35173138
42Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.33961655
43Vertebral hypoplasia (HP:0008417)3.33961655
44Exercise intolerance (HP:0003546)3.26065775
45Large for gestational age (HP:0001520)3.22073107
46Pancreatic islet-cell hyperplasia (HP:0004510)3.21882767
47Increased hepatocellular lipid droplets (HP:0006565)3.20473290
48Lactic acidosis (HP:0003128)3.10918400
49Decreased activity of mitochondrial respiratory chain (HP:0008972)3.06223649
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.06223649
51Short chin (HP:0000331)3.06028326
52Congenital hip dislocation (HP:0001374)3.05508534
53Mucopolysacchariduria (HP:0008155)3.05483390
54Urinary glycosaminoglycan excretion (HP:0003541)3.05483390
55Type 1 muscle fiber predominance (HP:0003803)3.05462117
56Reticulocytopenia (HP:0001896)3.04060889
57Diaphragmatic weakness (HP:0009113)2.99376932
58Lipid accumulation in hepatocytes (HP:0006561)2.99341467
59Polycythemia (HP:0001901)2.98155950
60Increased serum lactate (HP:0002151)2.96123420
61Increased muscle lipid content (HP:0009058)2.94589359
62Asymmetric septal hypertrophy (HP:0001670)2.94332816
63Intestinal atresia (HP:0011100)2.94046915
64Abnormality of cells of the erythroid lineage (HP:0012130)2.91052941
65Premature skin wrinkling (HP:0100678)2.89193064
66Squamous cell carcinoma (HP:0002860)2.84511312
67Basal cell carcinoma (HP:0002671)2.84403852
68Myopathic facies (HP:0002058)2.84084727
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81892761
70Abnormality of alanine metabolism (HP:0010916)2.81892761
71Hyperalaninemia (HP:0003348)2.81892761
72Abnormality of male internal genitalia (HP:0000022)2.80440903
73Rimmed vacuoles (HP:0003805)2.76350967
74Absent radius (HP:0003974)2.74071921
75Muscle hypertrophy of the lower extremities (HP:0008968)2.73863921
76Anteriorly placed anus (HP:0001545)2.73609284
77Broad alveolar ridges (HP:0000187)2.72188773
78Albinism (HP:0001022)2.72048001
79Growth hormone excess (HP:0000845)2.70239499
80Abnormality of polysaccharide metabolism (HP:0011012)2.68915146
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68915146
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68915146
83Cerebral aneurysm (HP:0004944)2.67091845
84Renal Fanconi syndrome (HP:0001994)2.65170449
85Absent thumb (HP:0009777)2.63981278
86Exercise-induced myalgia (HP:0003738)2.62913064
87Dysostosis multiplex (HP:0000943)2.61873436
88Selective tooth agenesis (HP:0001592)2.61856301
89Abnormal number of erythroid precursors (HP:0012131)2.61620151
90Dysautonomia (HP:0002459)2.60443679
91Hypochromic anemia (HP:0001931)2.58418626
92Hypotrichosis (HP:0001006)2.57392267
93Distal arthrogryposis (HP:0005684)2.55947184
94Hamartoma (HP:0010566)2.55643313
95Abnormality of the aortic arch (HP:0012303)2.55039150
96Type I transferrin isoform profile (HP:0003642)2.54786462
97Alacrima (HP:0000522)2.54727326
98Absent forearm bone (HP:0003953)2.53800797
99Aplasia involving forearm bones (HP:0009822)2.53800797
100Muscle fiber atrophy (HP:0100295)2.51852276
101Joint stiffness (HP:0001387)2.48904905
102Respiratory failure (HP:0002878)2.48789126
103Macrocytic anemia (HP:0001972)2.47775756
104Ketoacidosis (HP:0001993)2.47506339
105Calf muscle hypertrophy (HP:0008981)2.44660708
106Hypokinesia (HP:0002375)2.39512677
107Bowed forearm bones (HP:0003956)2.37347368
108Bowing of the arm (HP:0006488)2.37347368
109Microvesicular hepatic steatosis (HP:0001414)2.35855791
110Generalized amyotrophy (HP:0003700)2.32364570
111Choanal stenosis (HP:0000452)2.30989410
112Respiratory difficulties (HP:0002880)2.30914633
113Myoglobinuria (HP:0002913)2.29895087
1143-Methylglutaconic aciduria (HP:0003535)2.27157576
115Hyperglycinuria (HP:0003108)2.21919165
116Leukodystrophy (HP:0002415)2.20008956
117Hypobetalipoproteinemia (HP:0003563)2.19740385
118Astrocytoma (HP:0009592)2.19538939
119Abnormality of the astrocytes (HP:0100707)2.19538939
120Abnormality of the pancreatic islet cells (HP:0006476)2.18445133
121Abnormality of endocrine pancreas physiology (HP:0012093)2.18445133
122Bulbar palsy (HP:0001283)2.16704226
123Optic disc pallor (HP:0000543)2.16676149
124Redundant skin (HP:0001582)2.16448437
125Myotonia (HP:0002486)2.13776941
126Calcaneovalgus deformity (HP:0001848)2.13642786
127IgA deficiency (HP:0002720)2.13367643
128Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13011173
129Vertebral fusion (HP:0002948)2.11713592
130Lower limb hyperreflexia (HP:0002395)2.11158906
131Premature graying of hair (HP:0002216)2.10746387
132Hypercortisolism (HP:0001578)2.10578284
133Patellar aplasia (HP:0006443)2.10522272
134Bifid uvula (HP:0000193)2.09704270
135Hypotelorism (HP:0000601)2.08972946
136Volvulus (HP:0002580)2.07814890
137Hyperglycinemia (HP:0002154)2.07086458
138Clumsiness (HP:0002312)2.07037122
139Progressive muscle weakness (HP:0003323)2.06012507
140Stenosis of the external auditory canal (HP:0000402)2.04184969
141Abnormal protein glycosylation (HP:0012346)2.04143037
142Abnormal glycosylation (HP:0012345)2.04143037
143Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04143037
144Abnormal protein N-linked glycosylation (HP:0012347)2.04143037
145Aplasia of the musculature (HP:0100854)2.03400146
146Amniotic constriction ring (HP:0009775)2.01935947
147Abnormality of placental membranes (HP:0011409)2.01935947
148Multiple enchondromatosis (HP:0005701)2.01693579
149Lethargy (HP:0001254)2.01587476
150Abnormality of glycine metabolism (HP:0010895)1.99101832
151Abnormality of serine family amino acid metabolism (HP:0010894)1.99101832
152Cerebral hypomyelination (HP:0006808)1.98337672
153EMG: myopathic abnormalities (HP:0003458)1.97912224
154Abnormality of serum amino acid levels (HP:0003112)1.97370480
155Abnormality of the lower motor neuron (HP:0002366)1.96148317
156Capillary hemangiomas (HP:0005306)1.93839372
157Dicarboxylic aciduria (HP:0003215)1.92396231
158Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92396231
159Hyperammonemia (HP:0001987)1.91191586
160Aplasia/Hypoplasia of the patella (HP:0006498)1.89795676
161Deformed tarsal bones (HP:0008119)1.88623895
162Ketosis (HP:0001946)1.87878777
163Degeneration of anterior horn cells (HP:0002398)1.87141377
164Abnormality of the anterior horn cell (HP:0006802)1.87141377
165CNS demyelination (HP:0007305)1.86056108
166Ragged-red muscle fibers (HP:0003200)1.85142484
167Abnormality of the calf musculature (HP:0001430)1.84467787
168Neck muscle weakness (HP:0000467)1.84110212
169Gastrointestinal dysmotility (HP:0002579)1.83800960
170Reduced antithrombin III activity (HP:0001976)1.83716563
171Popliteal pterygium (HP:0009756)1.82608363
172Neoplasm of the adrenal gland (HP:0100631)1.82056435
173Muscle stiffness (HP:0003552)1.81682925
174Split hand (HP:0001171)1.81665252
175Colon cancer (HP:0003003)1.81278634
176Pancreatic fibrosis (HP:0100732)1.77696592
177Gastrointestinal atresia (HP:0002589)1.77217563
178Abnormality of the labia minora (HP:0012880)1.77064976
179Methylmalonic acidemia (HP:0002912)1.76495483
180Metaphyseal cupping (HP:0003021)1.76367056
181Decreased lacrimation (HP:0000633)1.74895742
182Ependymoma (HP:0002888)1.74694923
183Shoulder girdle muscle weakness (HP:0003547)1.71988593
184Aplastic anemia (HP:0001915)1.70709150
185Horseshoe kidney (HP:0000085)1.70465623
186Pancytopenia (HP:0001876)1.70186955
187Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.68809510
188Methylmalonic aciduria (HP:0012120)1.68690467
189Type 2 muscle fiber atrophy (HP:0003554)1.68393125
190Microretrognathia (HP:0000308)1.67919156
191Abnormality of renal resorption (HP:0011038)1.63881230
192Pallor (HP:0000980)1.60026291
193X-linked dominant inheritance (HP:0001423)1.58802553
194Paralysis (HP:0003470)1.58384423
195Abnormality of fatty-acid metabolism (HP:0004359)1.57174438
196Aplasia/Hypoplasia of the sacrum (HP:0008517)1.56954700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.80708200
2MAPK154.91281028
3DDR24.76153492
4MAP3K64.27022792
5VRK24.20046420
6OBSCN3.93213430
7TSSK63.65636357
8MAP3K113.53586089
9PINK13.25197757
10MATK2.80144689
11TYRO32.75268769
12SRPK12.61249309
13FGR2.60992152
14DAPK12.35659866
15STK162.32253031
16PDK22.28086899
17BMX2.25133634
18PBK2.18931649
19UHMK12.16914861
20PIM22.15127211
21PDGFRA2.13063824
22EIF2AK12.07594966
23CSK2.05811829
24VRK12.03695735
25DYRK1B1.99441941
26PRKD21.97956352
27NUAK11.91088786
28TRIM281.86262987
29ZAK1.85435163
30NME11.81729051
31YES11.73375944
32CDK71.68506215
33LIMK11.58254059
34EIF2AK31.53667369
35PLK31.53468511
36TAF11.50209781
37MAP3K101.48421731
38PLK41.47824996
39PHKG11.45754911
40PHKG21.45754911
41TRIB31.45273771
42CDK61.44962302
43LATS21.42285834
44DYRK21.40219100
45PIM11.34714002
46TRPM71.34308088
47TIE11.29735418
48MAPK111.29722675
49BMPR1B1.28691337
50RPS6KL11.24653677
51RPS6KC11.24653677
52BCKDK1.19061384
53NEK11.15939024
54CDC42BPA1.13742654
55MKNK11.11672865
56CSNK1G31.08938138
57RPS6KA61.07441626
58GSK3A1.04000218
59ARAF1.03289398
60AKT30.98545142
61CSNK1G10.93854730
62WNK30.91384960
63MST40.90031395
64EIF2AK20.89986966
65RPS6KB20.88628585
66TLK10.87116645
67MAP3K120.87080613
68BRAF0.86562661
69DYRK30.86134633
70CHEK20.85258310
71CDK190.84850415
72PLK10.80773254
73MTOR0.79907177
74CSNK1A1L0.79012725
75CSNK1G20.77042432
76CDK80.76238549
77DAPK30.75048486
78MKNK20.74863553
79PRKAA10.73275798
80SCYL20.73192234
81MAPKAPK30.72435553
82RPS6KA10.71431916
83BRSK10.70139887
84CCNB10.69427106
85SMG10.69414136
86TAOK20.68365679
87RPS6KA50.67791994
88FLT30.65243313
89PKN20.63505078
90HIPK20.62675885
91MAP4K20.59834979
92KDR0.56209368
93TTN0.55935195
94MAPKAPK50.55740090
95LRRK20.55405729
96RAF10.54680516
97TGFBR10.54613470
98NEK20.53505331
99CDK120.52647183
100TESK10.52032167
101ERBB40.51356566
102ILK0.51057575
103DMPK0.50878657
104EPHA20.50718426
105MUSK0.49274666
106GRK10.48901058
107PNCK0.48745026
108ATR0.48651856
109WNK40.48379690
110ABL20.47884834
111RPS6KA40.47194991
112ERBB30.47120824
113WEE10.46624263
114MOS0.46454518
115RIPK10.44603953
116CDK20.44288242
117BCR0.43512239
118CSNK1E0.41870229
119EGFR0.41562002
120AURKA0.40264661
121CDK40.40126850
122PRKAA20.39919501
123CSNK2A10.39886016
124STK40.39539702
125PAK10.39025326
126GRK50.37871236
127PDK40.37614008
128PDK30.37614008
129TAOK10.37122827
130ALK0.37100254
131CAMK2G0.36923218
132CDK30.36580219
133CDC70.36560443
134TESK20.35633874
135EPHB20.34672047
136MAPK40.33857658
137RPS6KB10.33550241
138BUB10.33441008
139SIK10.33439570
140PDGFRB0.31777357
141MAPK10.31478647
142MAPK30.31408217
143LYN0.31019335
144CSNK1A10.30952647
145ERN10.30866125
146AURKB0.30657057
147CSNK2A20.30144302
148STK390.29508171
149MAP3K90.29126082
150PAK40.28843909
151NME20.28242633
152PAK20.27909050
153STK100.27740160
154PTK20.26836667
155PRPF4B0.26155438
156PRKD10.25675823
157CHEK10.25089322
158MAP3K80.24399824
159EEF2K0.23552934
160MAPKAPK20.22431003
161MAPK140.21459477
162CAMK2B0.20913222
163CAMK2D0.20871649
164ATM0.20506728
165MAPK100.20447114
166AKT20.20238824
167TTK0.19309374
168STK30.18729271
169INSR0.18476132

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.01472622
2Mismatch repair_Homo sapiens_hsa034304.34944668
3Base excision repair_Homo sapiens_hsa034103.98756590
4Proteasome_Homo sapiens_hsa030503.66199458
5DNA replication_Homo sapiens_hsa030303.49584656
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.29809174
7Oxidative phosphorylation_Homo sapiens_hsa001903.17137041
8Parkinsons disease_Homo sapiens_hsa050123.09544618
9Biosynthesis of amino acids_Homo sapiens_hsa012302.45440789
10Fatty acid metabolism_Homo sapiens_hsa012122.31404353
11RNA polymerase_Homo sapiens_hsa030202.25432019
12Protein export_Homo sapiens_hsa030602.23241356
13Arginine and proline metabolism_Homo sapiens_hsa003302.20212924
14Huntingtons disease_Homo sapiens_hsa050162.17726846
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.00267449
16Alzheimers disease_Homo sapiens_hsa050101.97394969
17Sulfur relay system_Homo sapiens_hsa041221.91540776
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85875367
19Nucleotide excision repair_Homo sapiens_hsa034201.84087245
20Arginine biosynthesis_Homo sapiens_hsa002201.83128882
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78042696
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.77908219
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74955872
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69834000
25Non-homologous end-joining_Homo sapiens_hsa034501.68579771
26Folate biosynthesis_Homo sapiens_hsa007901.64076275
27mTOR signaling pathway_Homo sapiens_hsa041501.60656512
28Spliceosome_Homo sapiens_hsa030401.58071102
29RNA transport_Homo sapiens_hsa030131.55310053
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53989295
31Pyrimidine metabolism_Homo sapiens_hsa002401.51863483
32Notch signaling pathway_Homo sapiens_hsa043301.47600096
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46597141
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41896076
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41860194
36Circadian rhythm_Homo sapiens_hsa047101.36772364
37mRNA surveillance pathway_Homo sapiens_hsa030151.35717095
38Basal transcription factors_Homo sapiens_hsa030221.35518487
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32818141
40Lysine degradation_Homo sapiens_hsa003101.32593112
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32288725
42Hippo signaling pathway_Homo sapiens_hsa043901.27538791
43RNA degradation_Homo sapiens_hsa030181.27460053
44Homologous recombination_Homo sapiens_hsa034401.26614599
45Fructose and mannose metabolism_Homo sapiens_hsa000511.26502161
46Carbon metabolism_Homo sapiens_hsa012001.25648125
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22630475
48p53 signaling pathway_Homo sapiens_hsa041151.22011939
49Propanoate metabolism_Homo sapiens_hsa006401.20447438
50Hedgehog signaling pathway_Homo sapiens_hsa043401.13923476
51Adherens junction_Homo sapiens_hsa045201.13650692
52One carbon pool by folate_Homo sapiens_hsa006701.12250479
53Bladder cancer_Homo sapiens_hsa052191.10672538
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09904568
55Fatty acid degradation_Homo sapiens_hsa000711.09275812
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09221146
57Purine metabolism_Homo sapiens_hsa002301.08371722
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07943421
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05944742
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04739081
61Ribosome_Homo sapiens_hsa030101.03408926
62Pyruvate metabolism_Homo sapiens_hsa006200.97908903
63Steroid biosynthesis_Homo sapiens_hsa001000.92710514
64Fanconi anemia pathway_Homo sapiens_hsa034600.92262895
65Cell cycle_Homo sapiens_hsa041100.89845627
66Galactose metabolism_Homo sapiens_hsa000520.88013342
67Selenocompound metabolism_Homo sapiens_hsa004500.84887410
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84801067
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84383523
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.83632912
71Vitamin B6 metabolism_Homo sapiens_hsa007500.82142044
72TGF-beta signaling pathway_Homo sapiens_hsa043500.81919447
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81234312
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.77873676
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74589579
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.74587870
77Glutathione metabolism_Homo sapiens_hsa004800.74582576
78VEGF signaling pathway_Homo sapiens_hsa043700.73616791
79Tryptophan metabolism_Homo sapiens_hsa003800.71351151
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.70992168
81Shigellosis_Homo sapiens_hsa051310.67507051
82AMPK signaling pathway_Homo sapiens_hsa041520.66918489
83Nitrogen metabolism_Homo sapiens_hsa009100.61747703
84Starch and sucrose metabolism_Homo sapiens_hsa005000.60080071
85Fatty acid elongation_Homo sapiens_hsa000620.59820094
86Basal cell carcinoma_Homo sapiens_hsa052170.59690704
87Viral myocarditis_Homo sapiens_hsa054160.59452424
88Tyrosine metabolism_Homo sapiens_hsa003500.59402364
89Fat digestion and absorption_Homo sapiens_hsa049750.58490362
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57626063
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57238359
92Insulin signaling pathway_Homo sapiens_hsa049100.56006756
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.54356321
94Wnt signaling pathway_Homo sapiens_hsa043100.52645541
95Phenylalanine metabolism_Homo sapiens_hsa003600.51564530
96Oocyte meiosis_Homo sapiens_hsa041140.51282971
97PPAR signaling pathway_Homo sapiens_hsa033200.49486146
98Sulfur metabolism_Homo sapiens_hsa009200.48730571
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48174651
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46941424
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46211067
102Thyroid cancer_Homo sapiens_hsa052160.43228328
103Tight junction_Homo sapiens_hsa045300.42738992
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.42606469
105Colorectal cancer_Homo sapiens_hsa052100.42438687
106beta-Alanine metabolism_Homo sapiens_hsa004100.41727951
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40599290
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.40387693
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38708721
110Butanoate metabolism_Homo sapiens_hsa006500.37898462
111Primary immunodeficiency_Homo sapiens_hsa053400.36736158
112Dilated cardiomyopathy_Homo sapiens_hsa054140.36675802
113Legionellosis_Homo sapiens_hsa051340.36465750
114Acute myeloid leukemia_Homo sapiens_hsa052210.35624702
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35599691
116MicroRNAs in cancer_Homo sapiens_hsa052060.35219548
117Pentose phosphate pathway_Homo sapiens_hsa000300.35186331
118Small cell lung cancer_Homo sapiens_hsa052220.35151825
119Chronic myeloid leukemia_Homo sapiens_hsa052200.33516326
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32972525
121Cardiac muscle contraction_Homo sapiens_hsa042600.31520262
122Viral carcinogenesis_Homo sapiens_hsa052030.30946367
123N-Glycan biosynthesis_Homo sapiens_hsa005100.30438246
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29171421
125Peroxisome_Homo sapiens_hsa041460.28735340
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27751591
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27085426
128Glycerolipid metabolism_Homo sapiens_hsa005610.25373337
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23850161
130Glucagon signaling pathway_Homo sapiens_hsa049220.23791621
131Metabolic pathways_Homo sapiens_hsa011000.23460851
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23093368
133Chemical carcinogenesis_Homo sapiens_hsa052040.16607447
134Epstein-Barr virus infection_Homo sapiens_hsa051690.15587582
135Histidine metabolism_Homo sapiens_hsa003400.14923257
136Vitamin digestion and absorption_Homo sapiens_hsa049770.13516058
137Regulation of autophagy_Homo sapiens_hsa041400.12445386
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12123455
139Phototransduction_Homo sapiens_hsa047440.10680622

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