SAMSN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.20684002
2NIK/NF-kappaB signaling (GO:0038061)5.34028236
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.83359698
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.83359698
5antigen processing and presentation of endogenous antigen (GO:0019883)4.79205897
6negative regulation of interleukin-12 production (GO:0032695)4.77814318
7positive regulation of B cell differentiation (GO:0045579)4.25084000
8positive regulation of gamma-delta T cell activation (GO:0046645)4.22296488
9myeloid dendritic cell activation (GO:0001773)4.16304638
10regulation of T-helper 1 cell differentiation (GO:0045625)4.11220492
11defense response to protozoan (GO:0042832)4.09632454
12antigen processing and presentation via MHC class Ib (GO:0002475)4.09101994
13myeloid dendritic cell differentiation (GO:0043011)4.07509075
14regulation of vitamin D biosynthetic process (GO:0060556)4.00129018
15positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.92762465
16neutrophil activation involved in immune response (GO:0002283)3.90003114
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.89024825
18negative regulation of cell killing (GO:0031342)3.89024825
19regulation of RIG-I signaling pathway (GO:0039535)3.86626003
20positive regulation of natural killer cell differentiation (GO:0032825)3.85236539
21regulation of interleukin-12 biosynthetic process (GO:0045075)3.81960079
22regulation of chronic inflammatory response (GO:0002676)3.79621880
23lipopolysaccharide-mediated signaling pathway (GO:0031663)3.77964987
24response to interferon-beta (GO:0035456)3.76599675
25regulation of T cell tolerance induction (GO:0002664)3.75977918
26immunoglobulin mediated immune response (GO:0016064)3.73993569
27response to protozoan (GO:0001562)3.73152558
28regulation of interleukin-2 biosynthetic process (GO:0045076)3.72491941
29regulation of B cell differentiation (GO:0045577)3.70621498
30ribosomal small subunit assembly (GO:0000028)3.70205607
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.68897901
32T-helper 1 type immune response (GO:0042088)3.64898479
33response to muramyl dipeptide (GO:0032495)3.61621239
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.60369517
35positive regulation by organism of defense response of other organism involved in symbiotic interact3.60369517
36modulation by symbiont of host immune response (GO:0052553)3.60369517
37positive regulation by symbiont of host defense response (GO:0052509)3.60369517
38modulation by symbiont of host defense response (GO:0052031)3.60369517
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.60369517
40cellular response to type I interferon (GO:0071357)3.55582799
41type I interferon signaling pathway (GO:0060337)3.55582799
42positive regulation of T-helper cell differentiation (GO:0045624)3.54934030
43dendritic cell differentiation (GO:0097028)3.54880582
44negative thymic T cell selection (GO:0045060)3.53683457
45response to type I interferon (GO:0034340)3.51475043
46response to interleukin-15 (GO:0070672)3.50753388
47regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.50438071
48macrophage activation involved in immune response (GO:0002281)3.46966924
49regulation of tolerance induction (GO:0002643)3.46677514
50regulation of alpha-beta T cell proliferation (GO:0046640)3.44765938
51cellular response to interleukin-15 (GO:0071350)3.41062598
52mature B cell differentiation (GO:0002335)3.40679248
53cellular response to interferon-beta (GO:0035458)3.40520214
54positive regulation of alpha-beta T cell proliferation (GO:0046641)3.39640013
55positive regulation of antigen processing and presentation (GO:0002579)3.39075813
56Arp2/3 complex-mediated actin nucleation (GO:0034314)3.37725073
57positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.37455089
58regulation of necroptotic process (GO:0060544)3.37098348
59B cell mediated immunity (GO:0019724)3.36775003
60positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.34887196
61neutrophil activation (GO:0042119)3.34457223
62regulation of activation of Janus kinase activity (GO:0010533)3.31508400
63negative regulation of T cell mediated immunity (GO:0002710)3.31433994
64negative T cell selection (GO:0043383)3.30234498
65interferon-gamma-mediated signaling pathway (GO:0060333)3.28993498
66regulation of T-helper cell differentiation (GO:0045622)3.28504718
67positive regulation of T cell mediated cytotoxicity (GO:0001916)3.27737580
68positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.26102897
69mature B cell differentiation involved in immune response (GO:0002313)3.26067474
70regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.25510480
71regulation of hypersensitivity (GO:0002883)3.24985092
72response to peptidoglycan (GO:0032494)3.24215956
73positive regulation of interleukin-12 production (GO:0032735)3.23783550
74leukocyte aggregation (GO:0070486)3.22235842
75positive regulation of interleukin-2 production (GO:0032743)3.21999582
76tolerance induction (GO:0002507)3.21938271
77regulation of interferon-beta biosynthetic process (GO:0045357)3.20305527
78positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.20288547
79regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.19176718
80negative regulation of interleukin-17 production (GO:0032700)3.18695663
81necroptotic process (GO:0070266)3.18418773
82granulocyte activation (GO:0036230)3.18389890
83cellular extravasation (GO:0045123)3.18370732
84positive regulation of interleukin-10 production (GO:0032733)3.16550172
85regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.15119952
86regulation of natural killer cell mediated immunity (GO:0002715)3.15119952
87CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.12366191
88T-helper cell differentiation (GO:0042093)3.12366191
89regulation of vitamin metabolic process (GO:0030656)3.11618590
90germinal center formation (GO:0002467)3.10672977
91regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.10299471
92regulation of T cell mediated cytotoxicity (GO:0001914)3.09322781
93positive regulation of type 2 immune response (GO:0002830)3.08778322
94natural killer cell mediated immunity (GO:0002228)3.07981369
95natural killer cell mediated cytotoxicity (GO:0042267)3.07981369
96detection of molecule of bacterial origin (GO:0032490)3.07649092
97regulation of antigen processing and presentation (GO:0002577)3.07327052
98detection of other organism (GO:0098543)3.06915564
99positive regulation of tolerance induction (GO:0002645)3.06700935
100regulation of natural killer cell differentiation (GO:0032823)3.05917176
101regulation of regulatory T cell differentiation (GO:0045589)3.02867969
102positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.01817344
103cellular response to zinc ion (GO:0071294)3.01445671
104positive regulation of NF-kappaB import into nucleus (GO:0042346)3.00761200
105regulation of dendritic cell antigen processing and presentation (GO:0002604)2.98863005
106negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.98832790
107negative regulation of T-helper cell differentiation (GO:0045623)2.98832790
108positive regulation of natural killer cell activation (GO:0032816)2.97480280
109positive regulation of chemokine biosynthetic process (GO:0045080)2.97405991
110regulation of interferon-alpha production (GO:0032647)2.97094680
111regulation of B cell receptor signaling pathway (GO:0050855)2.96150868
112positive regulation of interleukin-17 production (GO:0032740)2.95247511
113regulation of interleukin-17 production (GO:0032660)2.94965694
114positive regulation of cytokine biosynthetic process (GO:0042108)2.94644001
115myeloid cell activation involved in immune response (GO:0002275)2.93999132
116regulation of memory T cell differentiation (GO:0043380)2.93184208
117positive regulation of natural killer cell mediated immunity (GO:0002717)2.92326070
118natural killer cell activation (GO:0030101)2.91765437
119cytidine metabolic process (GO:0046087)2.91719206
120cytidine catabolic process (GO:0006216)2.91719206
121cytidine deamination (GO:0009972)2.91719206
122negative regulation of cytokine production involved in immune response (GO:0002719)2.90516525
123regulation of natural killer cell activation (GO:0032814)2.90164110
124interferon-gamma production (GO:0032609)2.89535291
125positive regulation of interferon-alpha production (GO:0032727)2.89414706
126production of molecular mediator involved in inflammatory response (GO:0002532)2.86924924
127regulation of gamma-delta T cell differentiation (GO:0045586)2.85721518
128regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.85549813
129lymphocyte chemotaxis (GO:0048247)2.84748269
130positive regulation of activated T cell proliferation (GO:0042104)2.84440464
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.83720476
132regulation of interleukin-12 production (GO:0032655)2.82665170
133regulation of T-helper 1 type immune response (GO:0002825)2.82560208
134negative regulation of necroptotic process (GO:0060546)2.81237218
135T cell migration (GO:0072678)2.80993791
136positive regulation of defense response to virus by host (GO:0002230)2.79793219
137positive regulation of humoral immune response (GO:0002922)2.78865645
138regulation of gamma-delta T cell activation (GO:0046643)2.78550476
139positive regulation of T-helper 1 type immune response (GO:0002827)2.76762675
140response to interferon-alpha (GO:0035455)2.75834379
141definitive hemopoiesis (GO:0060216)2.75281301
142negative regulation of viral genome replication (GO:0045071)2.74762328
143mast cell activation (GO:0045576)2.74269494
144T cell homeostasis (GO:0043029)2.73931819
145natural killer cell differentiation (GO:0001779)2.73586358
146positive regulation of macrophage differentiation (GO:0045651)2.73556388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.78820605
2IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.75168159
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.62123558
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.40167570
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.78440696
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.72888607
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.65078806
8SCL_19346495_ChIP-Seq_HPC-7_Human3.56113236
9* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.33109286
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.26720691
11E2F7_22180533_ChIP-Seq_HELA_Human3.24734286
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.95265708
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.93558759
14* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.91227901
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.90157645
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.79991768
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76263253
18* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.64681935
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.58992514
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55355644
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49873832
22* SPI1_23547873_ChIP-Seq_NB4_Human2.49613074
23MYB_26560356_Chip-Seq_TH2_Human2.41880784
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.31305753
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.29732802
26RUNX_20019798_ChIP-Seq_JUKART_Human2.25172726
27GATA1_22025678_ChIP-Seq_K562_Human2.22042148
28VDR_21846776_ChIP-Seq_THP-1_Human2.17999438
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.16312075
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14684104
31MAF_26560356_Chip-Seq_TH1_Human2.12785874
32MYB_26560356_Chip-Seq_TH1_Human2.06858169
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.06337571
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.01092469
35VDR_24763502_ChIP-Seq_THP-1_Human1.93825515
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.89919143
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.88066714
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.85880971
39MYC_22102868_ChIP-Seq_BL_Human1.83362201
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82753141
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79517601
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.74192815
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73314471
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70679916
45* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66578707
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58908845
47GATA2_22383799_ChIP-Seq_G1ME_Mouse1.53979588
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47857057
49UTX_26944678_Chip-Seq_JUKART_Human1.47690374
50PU_27001747_Chip-Seq_BMDM_Mouse1.45663433
51TCF7_22412390_ChIP-Seq_EML_Mouse1.44388665
52* GATA3_27048872_Chip-Seq_THYMUS_Human1.42685582
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41938523
54* SPI1_23127762_ChIP-Seq_K562_Human1.40865408
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38907842
56* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38276789
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37667916
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35140854
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34485060
60MAF_26560356_Chip-Seq_TH2_Human1.33369377
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32926842
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31203458
63VDR_23849224_ChIP-Seq_CD4+_Human1.30384019
64* GATA1_19941826_ChIP-Seq_K562_Human1.29624846
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28317295
66* GATA3_26560356_Chip-Seq_TH2_Human1.25952879
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19546985
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18591597
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18248701
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17395931
71* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16133138
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.15907170
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11424315
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08806685
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.08683325
76VDR_24787735_ChIP-Seq_THP-1_Human1.05651565
77NCOR1_26117541_ChIP-Seq_K562_Human1.04316513
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.03933014
79* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03643459
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03279959
81* GATA2_19941826_ChIP-Seq_K562_Human1.03012064
82* FOXP3_21729870_ChIP-Seq_TREG_Human0.99304824
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99255182
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98458350
85ELK1_19687146_ChIP-ChIP_HELA_Human0.96823097
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96727318
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96463341
88EST1_17652178_ChIP-ChIP_JURKAT_Human0.93537627
89GATA2_21666600_ChIP-Seq_HMVEC_Human0.92006267
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91933644
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90159959
92* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89404010
93CIITA_25753668_ChIP-Seq_RAJI_Human0.89265666
94SRF_21415370_ChIP-Seq_HL-1_Mouse0.88568320
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88448160
96EGR1_19032775_ChIP-ChIP_M12_Human0.86990289
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86084524
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84584706
99MYC_18555785_ChIP-Seq_MESCs_Mouse0.83837296
100KDM2B_26808549_Chip-Seq_DND41_Human0.83133629
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81778839
102TFEB_21752829_ChIP-Seq_HELA_Human0.80768704
103ETS1_22383799_ChIP-Seq_G1ME_Mouse0.77086664
104KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76825035
105STAT1_20625510_ChIP-Seq_HELA_Human0.75797470
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75393521
107SMRT_27268052_Chip-Seq_Bcells_Human0.74275334
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.74226720
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.73606232
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.73529280
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.72573583
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71159086
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69775005
114XRN2_22483619_ChIP-Seq_HELA_Human0.65646557
115* GATA3_26560356_Chip-Seq_TH1_Human0.64055944
116STAT6_21828071_ChIP-Seq_BEAS2B_Human0.63864293
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.61894418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.96267503
2MP0000685_abnormal_immune_system3.86307604
3MP0005671_abnormal_response_to3.78000257
4MP0009785_altered_susceptibility_to3.61422780
5MP0002148_abnormal_hypersensitivity_rea3.31887043
6MP0003436_decreased_susceptibility_to3.07989211
7MP0005000_abnormal_immune_tolerance3.02055343
8MP0001790_abnormal_immune_system3.00788102
9MP0005387_immune_system_phenotype3.00788102
10* MP0001800_abnormal_humoral_immune2.86364426
11MP0002166_altered_tumor_susceptibility2.83528128
12MP0005025_abnormal_response_to2.74601361
13* MP0002452_abnormal_antigen_presenting2.66796938
14* MP0002723_abnormal_immune_serum2.66038103
15MP0002396_abnormal_hematopoietic_system2.61489060
16MP0001348_abnormal_lacrimal_gland2.55816793
17* MP0001819_abnormal_immune_cell2.51761518
18* MP0002420_abnormal_adaptive_immunity2.50972129
19MP0002419_abnormal_innate_immunity2.49565006
20MP0002006_tumorigenesis2.46775069
21MP0003763_abnormal_thymus_physiology2.41054484
22MP0003724_increased_susceptibility_to2.38674647
23MP0004510_myositis2.34801239
24MP0001853_heart_inflammation2.29000967
25* MP0002398_abnormal_bone_marrow2.26418459
26MP0005464_abnormal_platelet_physiology2.14204203
27* MP0000716_abnormal_immune_system2.08926249
28MP0002138_abnormal_hepatobiliary_system2.05961420
29MP0001873_stomach_inflammation2.02955188
30MP0001545_abnormal_hematopoietic_system2.01237939
31MP0005397_hematopoietic_system_phenotyp2.01237939
32MP0005310_abnormal_salivary_gland1.99108765
33MP0010155_abnormal_intestine_physiology1.90351621
34MP0002405_respiratory_system_inflammati1.89339891
35MP0002163_abnormal_gland_morphology1.83177182
36MP0006082_CNS_inflammation1.81949383
37MP0004808_abnormal_hematopoietic_stem1.81192988
38MP0000689_abnormal_spleen_morphology1.78127752
39* MP0002429_abnormal_blood_cell1.76628316
40MP0002722_abnormal_immune_system1.73606701
41MP0003303_peritoneal_inflammation1.72561784
42MP0001845_abnormal_inflammatory_respons1.66701404
43MP0005174_abnormal_tail_pigmentation1.65090080
44MP0009333_abnormal_splenocyte_physiolog1.63749364
45MP0002009_preneoplasia1.55511339
46MP0004947_skin_inflammation1.53915428
47MP0005167_abnormal_blood-brain_barrier1.41013837
48* MP0008469_abnormal_protein_level1.39801634
49MP0000490_abnormal_crypts_of1.39198706
50MP0008057_abnormal_DNA_replication1.38725383
51MP0000703_abnormal_thymus_morphology1.37005462
52MP0005451_abnormal_body_composition1.36424502
53MP0003866_abnormal_defecation1.34145523
54MP0009840_abnormal_foam_cell1.33047895
55MP0001533_abnormal_skeleton_physiology1.29352918
56MP0009764_decreased_sensitivity_to1.28202287
57MP0005075_abnormal_melanosome_morpholog1.27135484
58MP0008004_abnormal_stomach_pH1.22994256
59MP0003300_gastrointestinal_ulcer1.18143977
60MP0000465_gastrointestinal_hemorrhage1.16771810
61MP0002877_abnormal_melanocyte_morpholog1.10125428
62MP0008007_abnormal_cellular_replicative1.10011704
63MP0002254_reproductive_system_inflammat1.09840158
64MP0009278_abnormal_bone_marrow1.07762649
65MP0003806_abnormal_nucleotide_metabolis1.07321407
66MP0005379_endocrine/exocrine_gland_phen1.06254812
67MP0002933_joint_inflammation1.05601708
68MP0000858_altered_metastatic_potential1.04567742
69MP0003448_altered_tumor_morphology1.02876964
70MP0003045_fibrosis0.99986676
71MP0002277_abnormal_respiratory_mucosa0.99700653
72MP0002095_abnormal_skin_pigmentation0.99618692
73MP0000604_amyloidosis0.94146915
74MP0001346_abnormal_lacrimal_gland0.94077782
75MP0002019_abnormal_tumor_incidence0.91290068
76MP0000343_altered_response_to0.90865620
77MP0002332_abnormal_exercise_endurance0.84592075
78MP0005058_abnormal_lysosome_morphology0.81100234
79MP0009763_increased_sensitivity_to0.79353144
80MP0005164_abnormal_response_to0.78423005
81MP0004381_abnormal_hair_follicle0.77324611
82MP0003172_abnormal_lysosome_physiology0.77032225
83MP0000015_abnormal_ear_pigmentation0.76564501
84MP0003943_abnormal_hepatobiliary_system0.76545603
85MP0003453_abnormal_keratinocyte_physiol0.75706216
86MP0003191_abnormal_cellular_cholesterol0.75590901
87MP0003690_abnormal_glial_cell0.74406619
88MP0008058_abnormal_DNA_repair0.73546277
89MP0003075_altered_response_to0.73106032
90MP0002139_abnormal_hepatobiliary_system0.72521698
91MP0000371_diluted_coat_color0.72132585
92MP0000569_abnormal_digit_pigmentation0.69009006
93MP0010352_gastrointestinal_tract_polyps0.68637762
94MP0003183_abnormal_peptide_metabolism0.68461124
95MP0001851_eye_inflammation0.67644941
96MP0004883_abnormal_blood_vessel0.67060732
97MP0000249_abnormal_blood_vessel0.66775342
98MP0003195_calcinosis0.65839563
99MP0002998_abnormal_bone_remodeling0.65233241
100MP0009765_abnormal_xenobiotic_induced0.65053313
101MP0003646_muscle_fatigue0.63623822
102MP0008260_abnormal_autophagy0.63447048
103MP0003828_pulmonary_edema0.63306947
104MP0000313_abnormal_cell_death0.62908460
105MP0001663_abnormal_digestive_system0.62646993
106MP0002693_abnormal_pancreas_physiology0.62264310
107MP0004782_abnormal_surfactant_physiolog0.60742792
108MP0002132_abnormal_respiratory_system0.59900551
109MP0010307_abnormal_tumor_latency0.59667889
110MP0003795_abnormal_bone_structure0.59539207
111MP0000609_abnormal_liver_physiology0.58198624
112MP0003077_abnormal_cell_cycle0.56773076
113MP0005535_abnormal_body_temperature0.56325331
114MP0005390_skeleton_phenotype0.55204541
115MP0010094_abnormal_chromosome_stability0.54812746
116MP0003186_abnormal_redox_activity0.54375326
117MP0002928_abnormal_bile_duct0.53728655
118MP0000920_abnormal_myelination0.53300346
119MP0003656_abnormal_erythrocyte_physiolo0.53029001
120MP0001986_abnormal_taste_sensitivity0.52790163
121MP0003221_abnormal_cardiomyocyte_apopto0.52193525
122MP0005084_abnormal_gallbladder_morpholo0.51441845
123MP0003693_abnormal_embryo_hatching0.47347023
124MP0005166_decreased_susceptibility_to0.45901947

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.58274644
2Elevated erythrocyte sedimentation rate (HP:0003565)5.13209525
3Optic neuritis (HP:0100653)5.02657267
4Retrobulbar optic neuritis (HP:0100654)5.02657267
5Recurrent abscess formation (HP:0002722)5.01266308
6Recurrent bacterial skin infections (HP:0005406)4.81526119
7Orchitis (HP:0100796)4.78184266
8Eczematoid dermatitis (HP:0000976)4.43822019
9Thrombocytosis (HP:0001894)4.31825389
10Chronic otitis media (HP:0000389)4.20888065
11Recurrent fungal infections (HP:0002841)4.03081691
12Vasculitis (HP:0002633)3.88801083
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.84540893
14Abnormality of glycolipid metabolism (HP:0010969)3.81440523
15Abnormality of liposaccharide metabolism (HP:0010968)3.81440523
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.81440523
17Recurrent viral infections (HP:0004429)3.80358012
18Increased IgM level (HP:0003496)3.69183613
19IgM deficiency (HP:0002850)3.68152806
20Mediastinal lymphadenopathy (HP:0100721)3.64882123
21Autoimmune thrombocytopenia (HP:0001973)3.57401891
22Abnormality of macrophages (HP:0004311)3.46888911
23Recurrent skin infections (HP:0001581)3.40799501
24Recurrent bronchitis (HP:0002837)3.39487542
25Abnormality of B cell number (HP:0010975)3.36727546
26B lymphocytopenia (HP:0010976)3.36727546
27Abnormality of T cell physiology (HP:0011840)3.33737773
28Meningitis (HP:0001287)3.31552761
29Pulmonary infiltrates (HP:0002113)3.27955198
30Petechiae (HP:0000967)3.20230958
31Keratoconjunctivitis sicca (HP:0001097)3.19554805
32Aplastic anemia (HP:0001915)3.17682235
33Arterial thrombosis (HP:0004420)3.15781895
34Panhypogammaglobulinemia (HP:0003139)3.09185270
35Nasal polyposis (HP:0100582)3.06423740
36Recurrent cutaneous fungal infections (HP:0011370)3.03960096
37Chronic mucocutaneous candidiasis (HP:0002728)3.03960096
38Agammaglobulinemia (HP:0004432)3.02518195
39Hypergammaglobulinemia (HP:0010702)3.02423811
40Hemoptysis (HP:0002105)3.02395152
41IgG deficiency (HP:0004315)3.00024352
42Abnormality of T cells (HP:0002843)2.99048288
43Obstructive lung disease (HP:0006536)2.95536501
44Chronic obstructive pulmonary disease (HP:0006510)2.95536501
45Keratoconjunctivitis (HP:0001096)2.92613720
46Encephalitis (HP:0002383)2.92148470
47Fatigue (HP:0012378)2.91758911
48Abnormality of the nasal mucosa (HP:0000433)2.89784273
49Gastrointestinal infarctions (HP:0005244)2.87356555
50Cellulitis (HP:0100658)2.78743378
51Recurrent gram-negative bacterial infections (HP:0005420)2.76185791
52Spontaneous hematomas (HP:0007420)2.76043708
53Acute myeloid leukemia (HP:0004808)2.75678693
54Increased IgE level (HP:0003212)2.71701724
55Autoimmune hemolytic anemia (HP:0001890)2.70814101
56Abnormality of T cell number (HP:0011839)2.70322567
57Increased cerebral lipofuscin (HP:0011813)2.69934408
58Epistaxis (HP:0000421)2.68451565
59Inflammation of the large intestine (HP:0002037)2.67622504
60Leukocytosis (HP:0001974)2.65729386
61Anorexia (HP:0002039)2.64543199
62Chest pain (HP:0100749)2.63996555
63Abnormality of cells of the lymphoid lineage (HP:0012140)2.62993106
64Prolonged bleeding time (HP:0003010)2.62908113
65Granulocytopenia (HP:0001913)2.62673977
66Abnormality of the fingertips (HP:0001211)2.60760829
67Gingival bleeding (HP:0000225)2.60554853
68Gastrointestinal inflammation (HP:0004386)2.59481540
69Polyneuropathy (HP:0001271)2.58631412
70Chronic diarrhea (HP:0002028)2.58163076
71Abnormality of the prostate (HP:0008775)2.57686179
72Eosinophilia (HP:0001880)2.57543334
73Abnormality of eosinophils (HP:0001879)2.55479683
74Thyroiditis (HP:0100646)2.55051139
75Interstitial pulmonary disease (HP:0006530)2.54286840
76Gastrointestinal stroma tumor (HP:0100723)2.53072107
77Amaurosis fugax (HP:0100576)2.52814358
78Systemic lupus erythematosus (HP:0002725)2.50026203
79Disinhibition (HP:0000734)2.49262481
80Lymphopenia (HP:0001888)2.49026230
81Colitis (HP:0002583)2.47086725
82Stomatitis (HP:0010280)2.46277329
83Increased serum ferritin (HP:0003281)2.44473787
84Dysostosis multiplex (HP:0000943)2.39283622
85Combined immunodeficiency (HP:0005387)2.38904200
86Episodic fever (HP:0001954)2.36917428
87IgA deficiency (HP:0002720)2.36469188
88Pustule (HP:0200039)2.36097011
89Loss of speech (HP:0002371)2.34653378
90Neutropenia (HP:0001875)2.32377125
91Periodontitis (HP:0000704)2.32329104
92Abnormality of cells of the erythroid lineage (HP:0012130)2.28415133
93Abnormal number of erythroid precursors (HP:0012131)2.26538355
94Lymphoma (HP:0002665)2.23891791
95Albinism (HP:0001022)2.23001193
96Gangrene (HP:0100758)2.22487780
97Basal ganglia calcification (HP:0002135)2.22354396
98T lymphocytopenia (HP:0005403)2.21237182
99Increased neuronal autofluorescent lipopigment (HP:0002074)2.21136159
100Glomerulopathy (HP:0100820)2.18768287
101Gingivitis (HP:0000230)2.18752673
102Keratitis (HP:0000491)2.17769701
103Urticaria (HP:0001025)2.16197403
104Severe combined immunodeficiency (HP:0004430)2.15768437
105Vertigo (HP:0002321)2.15090737
106Hypertensive crisis (HP:0100735)2.13324488
107Pulmonary embolism (HP:0002204)2.13259402
108Reticulocytopenia (HP:0001896)2.13210432
109Arthralgia (HP:0002829)2.11378371
110Recurrent pneumonia (HP:0006532)2.11182788
111Exertional dyspnea (HP:0002875)2.10111145
112Abnormality of the pleura (HP:0002103)2.09404539
113Abnormal platelet function (HP:0011869)2.09224306
114Impaired platelet aggregation (HP:0003540)2.09224306
115Hematochezia (HP:0002573)2.08331762
116Osteomyelitis (HP:0002754)2.05732602
117Vacuolated lymphocytes (HP:0001922)2.05367180
118Abnormality of iron homeostasis (HP:0011031)2.04924738
119Alveolar cell carcinoma (HP:0006519)2.04222619
120Amyloidosis (HP:0011034)2.02768861
121Recurrent lower respiratory tract infections (HP:0002783)2.01834553
122Hypochromic anemia (HP:0001931)2.01292326
123Joint swelling (HP:0001386)1.99382229
124Mutism (HP:0002300)1.98701969
125Abnormality of the endocardium (HP:0004306)1.98536035
126Thrombophlebitis (HP:0004418)1.96998345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.23968347
2TXK3.58145328
3MAP4K13.57175192
4KIT3.23342370
5TBK13.05695389
6JAK33.04311522
7IKBKB2.91123101
8IRAK42.89246596
9FLT32.81730649
10TYK22.80921407
11IKBKE2.57361254
12TEC2.31915168
13BTK2.20936370
14MAP3K132.20156853
15CSF1R2.19597812
16CHUK1.97804385
17GRK71.96826757
18PIM21.89593131
19ZAP701.85043333
20PRPF4B1.82746076
21SYK1.82302119
22BLK1.77174281
23JAK11.66972308
24RIPK41.52706650
25IRAK31.51068276
26TAOK21.46353435
27PIM11.38110221
28NME21.37892721
29MAP2K31.36678120
30TGFBR11.32898438
31MATK1.27116146
32LCK1.25272656
33FGR1.24090613
34TAOK31.19306305
35NLK1.18457798
36TGFBR21.14589722
37RPS6KA41.11117317
38LYN1.10185976
39EPHB11.07735152
40MARK31.03484490
41MAP3K11.02119805
42ITK0.98074023
43FES0.97907885
44HCK0.96959847
45MAP3K120.96355910
46MAP2K60.96152946
47IRAK20.92360199
48STK160.89376376
49JAK20.89091755
50EEF2K0.89050489
51ACVR1B0.88070224
52NEK90.82020768
53ADRBK20.81426996
54TNIK0.81367131
55KSR20.80045474
56FGFR40.78025152
57EPHA30.77608329
58MAP3K30.77211571
59TAOK10.76457384
60FGFR30.75838192
61PIK3CG0.75751614
62LRRK20.75125992
63MOS0.74805593
64KDR0.72406905
65CAMKK20.71593351
66EIF2AK20.70518065
67MUSK0.69444597
68MAPKAPK20.69257691
69STK40.68542111
70CSK0.67535524
71IRAK10.64463622
72TNK20.64223870
73BMPR20.63942705
74MAP3K50.63620632
75MAPKAPK50.62547430
76RPS6KA50.61146360
77GRK60.61052518
78STK100.60097502
79TYRO30.59424073
80CLK10.57514314
81CDC42BPA0.57404931
82SIK30.56623752
83DDR20.56203805
84VRK10.54611634
85PDK10.52678699
86MAP3K110.51386611
87MKNK10.50257627
88WEE10.49518432
89SCYL20.47057073
90RIPK10.46604721
91TRPM70.46489147
92PRKCD0.43355335
93PRKAA20.42806579
94TESK20.42478993
95ABL10.41403954
96MAP3K60.40544073
97ATR0.39314119
98STK240.39095040
99RPS6KB20.39054809
100RPS6KA60.38934691
101RAF10.38826647
102YES10.38373879
103MAPKAPK30.38349979
104CDK190.37557963
105PRKCQ0.37282811
106PRKG20.36418690
107DAPK20.36387242
108EIF2AK30.35870130
109ERN10.35484007
110DYRK30.35424925
111CDK40.34910694
112FYN0.34571867
113HIPK20.33753044
114KSR10.31329190
115NEK20.31278320
116MAPK40.31124236
117CDK60.31105253
118MAP3K20.31003085
119EGFR0.30376098
120MST40.30177661
121MAPK110.29249498
122NUAK10.26292829
123ALK0.25471873
124INSR0.24806949
125MAPK30.24641484
126BRSK20.24423564
127IGF1R0.24368964
128CCNB10.24245165
129RPS6KA10.23951028
130EIF2AK10.21718067
131PDK20.21030380
132PDPK10.20765667
133MAPK70.19261367

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.09587062
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.09009446
3Leishmaniasis_Homo sapiens_hsa051402.94476821
4Graft-versus-host disease_Homo sapiens_hsa053322.75721437
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.74699194
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.72117414
7Primary immunodeficiency_Homo sapiens_hsa053402.55904148
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.54552738
9Autoimmune thyroid disease_Homo sapiens_hsa053202.54040127
10Measles_Homo sapiens_hsa051622.42374314
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.32687453
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.20394713
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18667623
14Asthma_Homo sapiens_hsa053102.04964038
15Type I diabetes mellitus_Homo sapiens_hsa049401.97524839
16Herpes simplex infection_Homo sapiens_hsa051681.91701129
17Osteoclast differentiation_Homo sapiens_hsa043801.91245454
18Legionellosis_Homo sapiens_hsa051341.85769195
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.83748921
20B cell receptor signaling pathway_Homo sapiens_hsa046621.79569835
21Antigen processing and presentation_Homo sapiens_hsa046121.71090810
22Ribosome_Homo sapiens_hsa030101.70645745
23TNF signaling pathway_Homo sapiens_hsa046681.68725506
24Hematopoietic cell lineage_Homo sapiens_hsa046401.66728957
25Toxoplasmosis_Homo sapiens_hsa051451.65585317
26Pertussis_Homo sapiens_hsa051331.63389734
27DNA replication_Homo sapiens_hsa030301.60933398
28Influenza A_Homo sapiens_hsa051641.59782027
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53209331
30Shigellosis_Homo sapiens_hsa051311.44115729
31Malaria_Homo sapiens_hsa051441.42607923
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41649475
33Apoptosis_Homo sapiens_hsa042101.38634238
34African trypanosomiasis_Homo sapiens_hsa051431.33523937
35T cell receptor signaling pathway_Homo sapiens_hsa046601.33280965
36Base excision repair_Homo sapiens_hsa034101.29697685
37Tuberculosis_Homo sapiens_hsa051521.28700672
38Chemokine signaling pathway_Homo sapiens_hsa040621.26419383
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22775280
40Acute myeloid leukemia_Homo sapiens_hsa052211.22190993
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22134871
42Viral myocarditis_Homo sapiens_hsa054161.13423305
43Hepatitis B_Homo sapiens_hsa051611.12988608
44Salmonella infection_Homo sapiens_hsa051321.10614891
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08392341
46Epstein-Barr virus infection_Homo sapiens_hsa051691.03709645
47Mismatch repair_Homo sapiens_hsa034301.03614405
48Rheumatoid arthritis_Homo sapiens_hsa053231.01628562
49Staphylococcus aureus infection_Homo sapiens_hsa051500.99957610
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99491251
51Proteasome_Homo sapiens_hsa030500.91321107
52p53 signaling pathway_Homo sapiens_hsa041150.89722210
53Homologous recombination_Homo sapiens_hsa034400.88473595
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86090766
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83244584
56Platelet activation_Homo sapiens_hsa046110.79860658
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76953608
58Hepatitis C_Homo sapiens_hsa051600.76070355
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73421878
60Prolactin signaling pathway_Homo sapiens_hsa049170.73038465
61Chronic myeloid leukemia_Homo sapiens_hsa052200.70847517
62Viral carcinogenesis_Homo sapiens_hsa052030.70634436
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67313491
64Other glycan degradation_Homo sapiens_hsa005110.65203336
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.64754007
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64606046
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63795700
68Prion diseases_Homo sapiens_hsa050200.62487984
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62287637
70Small cell lung cancer_Homo sapiens_hsa052220.60945945
71Spliceosome_Homo sapiens_hsa030400.58945695
72Non-homologous end-joining_Homo sapiens_hsa034500.58558104
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55989026
74HTLV-I infection_Homo sapiens_hsa051660.55012840
75Pyrimidine metabolism_Homo sapiens_hsa002400.53566261
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.51648997
77Pancreatic cancer_Homo sapiens_hsa052120.48629919
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.47797012
79Nucleotide excision repair_Homo sapiens_hsa034200.47495508
80RNA polymerase_Homo sapiens_hsa030200.45841957
81Dorso-ventral axis formation_Homo sapiens_hsa043200.43249934
82RNA degradation_Homo sapiens_hsa030180.42663885
83Systemic lupus erythematosus_Homo sapiens_hsa053220.42094581
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42006515
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41994458
86Bladder cancer_Homo sapiens_hsa052190.40052325
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39573347
88Caffeine metabolism_Homo sapiens_hsa002320.37428392
89Type II diabetes mellitus_Homo sapiens_hsa049300.36129728
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35667065
91Fanconi anemia pathway_Homo sapiens_hsa034600.32421034
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.30777789
93Renal cell carcinoma_Homo sapiens_hsa052110.29588111
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28755213
95HIF-1 signaling pathway_Homo sapiens_hsa040660.28474557
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28280298
97Phagosome_Homo sapiens_hsa041450.24988012
98FoxO signaling pathway_Homo sapiens_hsa040680.24087173
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23850512
100One carbon pool by folate_Homo sapiens_hsa006700.23687968
101Cell cycle_Homo sapiens_hsa041100.22166727
102Non-small cell lung cancer_Homo sapiens_hsa052230.22054146
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.21337420
104VEGF signaling pathway_Homo sapiens_hsa043700.20570256
105Insulin resistance_Homo sapiens_hsa049310.20143754
106Amoebiasis_Homo sapiens_hsa051460.19150709
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19134979
108Lysosome_Homo sapiens_hsa041420.19116689
109Basal transcription factors_Homo sapiens_hsa030220.18480904
110MAPK signaling pathway_Homo sapiens_hsa040100.18456647
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18283663
112Complement and coagulation cascades_Homo sapiens_hsa046100.18194121
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17450441
114Pentose phosphate pathway_Homo sapiens_hsa000300.16957348
115Endocytosis_Homo sapiens_hsa041440.16102761
116Collecting duct acid secretion_Homo sapiens_hsa049660.14982762
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11236667
118mTOR signaling pathway_Homo sapiens_hsa041500.10809561
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.08469263
120Prostate cancer_Homo sapiens_hsa052150.07597380
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07031633
122Sphingolipid metabolism_Homo sapiens_hsa006000.05333145
123GnRH signaling pathway_Homo sapiens_hsa049120.03738836
124Mineral absorption_Homo sapiens_hsa049780.03521622
125ErbB signaling pathway_Homo sapiens_hsa040120.03145623

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