SAP130

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.68313909
2DNA strand elongation involved in DNA replication (GO:0006271)5.06967923
3DNA strand elongation (GO:0022616)4.94950232
4DNA replication initiation (GO:0006270)4.91300071
5nuclear pore complex assembly (GO:0051292)4.85960001
6nuclear pore organization (GO:0006999)4.73213157
7mitotic sister chromatid cohesion (GO:0007064)4.67077985
8negative regulation of histone methylation (GO:0031061)4.32425166
9DNA topological change (GO:0006265)4.24738659
10chromosome condensation (GO:0030261)4.19497400
11regulation of RNA export from nucleus (GO:0046831)4.14663379
12histone H4-K12 acetylation (GO:0043983)4.02040219
13mitotic nuclear envelope disassembly (GO:0007077)3.98767096
14mitotic sister chromatid segregation (GO:0000070)3.95245599
15positive regulation of mitotic sister chromatid separation (GO:1901970)3.90425571
16positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.90425571
17positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.90425571
18sister chromatid segregation (GO:0000819)3.89026737
19glucocorticoid receptor signaling pathway (GO:0042921)3.84018010
20pore complex assembly (GO:0046931)3.79517347
21heterochromatin organization (GO:0070828)3.76221063
22DNA packaging (GO:0006323)3.75618916
23membrane disassembly (GO:0030397)3.74819983
24nuclear envelope disassembly (GO:0051081)3.74819983
25DNA replication checkpoint (GO:0000076)3.71484608
26protein localization to kinetochore (GO:0034501)3.69302846
27regulation of sister chromatid cohesion (GO:0007063)3.62629501
28paraxial mesoderm development (GO:0048339)3.59463949
29mitotic chromosome condensation (GO:0007076)3.55909597
30intracellular estrogen receptor signaling pathway (GO:0030520)3.54673846
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52127969
32telomere maintenance via semi-conservative replication (GO:0032201)3.49664990
33NLS-bearing protein import into nucleus (GO:0006607)3.48785589
34protein localization to chromosome, centromeric region (GO:0071459)3.47489249
35mRNA stabilization (GO:0048255)3.46328581
36RNA stabilization (GO:0043489)3.46328581
37positive regulation of chromosome segregation (GO:0051984)3.45034972
38establishment of integrated proviral latency (GO:0075713)3.44841524
39nucleosome disassembly (GO:0006337)3.44203650
40protein-DNA complex disassembly (GO:0032986)3.44203650
41dosage compensation (GO:0007549)3.42769736
42DNA synthesis involved in DNA repair (GO:0000731)3.42580310
43positive regulation of gene expression, epigenetic (GO:0045815)3.39109644
44regulation of nucleobase-containing compound transport (GO:0032239)3.37962928
45gene silencing by RNA (GO:0031047)3.37247521
46L-serine metabolic process (GO:0006563)3.35308941
47DNA conformation change (GO:0071103)3.33891441
48DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.31186927
49regulation of double-strand break repair via homologous recombination (GO:0010569)3.24434006
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22730839
51cytoplasmic mRNA processing body assembly (GO:0033962)3.22064230
52protein localization to chromosome (GO:0034502)3.17983089
53regulation of histone H3-K9 methylation (GO:0051570)3.16376311
54histone H4-K8 acetylation (GO:0043982)3.15229470
55histone H4-K5 acetylation (GO:0043981)3.15229470
56corticosteroid receptor signaling pathway (GO:0031958)3.12505353
57histone H3-K4 methylation (GO:0051568)3.09437571
58DNA damage response, signal transduction resulting in transcription (GO:0042772)3.08397432
59regulation of spindle organization (GO:0090224)3.06565742
60peptidyl-arginine omega-N-methylation (GO:0035247)3.06291848
61gene silencing (GO:0016458)3.05119912
62RNA localization (GO:0006403)3.04886124
63protein complex localization (GO:0031503)3.02621209
64negative regulation of mRNA processing (GO:0050686)3.01672234
65regulation of histone methylation (GO:0031060)3.01578885
66regulation of double-strand break repair (GO:2000779)3.01519149
67regulation of mitotic spindle organization (GO:0060236)3.00380012
68regulation of histone H3-K4 methylation (GO:0051569)2.99928796
69positive regulation of SMAD protein import into nucleus (GO:0060391)2.99490483
70nuclear envelope organization (GO:0006998)2.98568993
71chromosome segregation (GO:0007059)2.97726124
72histone H4-K16 acetylation (GO:0043984)2.96926986
73DNA unwinding involved in DNA replication (GO:0006268)2.96698380
74histone H2A monoubiquitination (GO:0035518)2.95148225
75regulation of NFAT protein import into nucleus (GO:0051532)2.94634690
76ATP-dependent chromatin remodeling (GO:0043044)2.92703379
77negative regulation of mRNA metabolic process (GO:1903312)2.92694544
78cellular protein complex localization (GO:0034629)2.92006843
79regulation of translational fidelity (GO:0006450)2.91528662
80negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90565530
81regulation of telomere maintenance via telomerase (GO:0032210)2.89926422
82establishment of chromosome localization (GO:0051303)2.88928775
83regulation of chromosome segregation (GO:0051983)2.88922430
84negative regulation of DNA repair (GO:0045738)2.88663985
85mitotic metaphase plate congression (GO:0007080)2.86963279
86N-terminal protein amino acid acetylation (GO:0006474)2.86599114
87negative regulation of gene expression, epigenetic (GO:0045814)2.85945443
88chromatin assembly or disassembly (GO:0006333)2.85716986
89histone H4 acetylation (GO:0043967)2.84330186
90regulation of DNA damage checkpoint (GO:2000001)2.83036018
91peptidyl-arginine N-methylation (GO:0035246)2.83014985
92peptidyl-arginine methylation (GO:0018216)2.83014985
93nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.82272473
94stress granule assembly (GO:0034063)2.81890589
95DNA ligation (GO:0006266)2.80992208
96peptidyl-lysine dimethylation (GO:0018027)2.80959665
97regulation of DNA methylation (GO:0044030)2.79274494
98telomere maintenance via recombination (GO:0000722)2.77692330
99DNA alkylation (GO:0006305)2.77364131
100DNA methylation (GO:0006306)2.77364131
101kinetochore organization (GO:0051383)2.76729279
102alternative mRNA splicing, via spliceosome (GO:0000380)2.76590008
103spliceosomal tri-snRNP complex assembly (GO:0000244)2.76001216
104DNA replication-independent nucleosome assembly (GO:0006336)2.75700524
105DNA replication-independent nucleosome organization (GO:0034724)2.75700524
106negative regulation of histone modification (GO:0031057)2.75196371
107mitotic recombination (GO:0006312)2.73183956
108trophectodermal cell differentiation (GO:0001829)2.73104597
109chromatin remodeling at centromere (GO:0031055)2.72311933
110histone H3-K9 methylation (GO:0051567)2.72028216
111negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.71667946
112sister chromatid cohesion (GO:0007062)2.71119420
113microtubule depolymerization (GO:0007019)2.70279632
114regulation of histone H3-K27 methylation (GO:0061085)2.69747731
115negative regulation of chromosome segregation (GO:0051985)2.68930534
116DNA geometric change (GO:0032392)2.68903988
117regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68862528
118DNA duplex unwinding (GO:0032508)2.67696083
119embryonic camera-type eye development (GO:0031076)2.66745412
120mRNA transport (GO:0051028)2.66426766
121chromatin assembly (GO:0031497)2.66009172
122regulation of mRNA stability (GO:0043488)2.65466253
123histone arginine methylation (GO:0034969)2.65049774
124regulation of stem cell maintenance (GO:2000036)2.64745510
125metaphase plate congression (GO:0051310)2.64725966
126histone lysine methylation (GO:0034968)2.64339994
127regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.63427670
128establishment of viral latency (GO:0019043)2.63045908
129DNA replication-dependent nucleosome assembly (GO:0006335)2.62581814
130DNA replication-dependent nucleosome organization (GO:0034723)2.62581814
131regulation of centriole replication (GO:0046599)2.62355555
132histone methylation (GO:0016571)2.62019679
133regulation of chromatin binding (GO:0035561)2.61719900
134regulation of RNA stability (GO:0043487)2.61279485
135regulation of sister chromatid segregation (GO:0033045)2.61053296
136regulation of mitotic sister chromatid separation (GO:0010965)2.61053296
137regulation of mitotic sister chromatid segregation (GO:0033047)2.61053296
138regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.60906396
139negative regulation of chromatin modification (GO:1903309)2.60600525
140regulation of gene silencing by RNA (GO:0060966)2.60179585
141regulation of posttranscriptional gene silencing (GO:0060147)2.60179585
142regulation of gene silencing by miRNA (GO:0060964)2.60179585
143hippo signaling (GO:0035329)2.60060878
144spindle assembly checkpoint (GO:0071173)2.59674683
145chromatin silencing (GO:0006342)2.59071378
146positive regulation of DNA-dependent DNA replication (GO:2000105)2.57022154
147regulation of centrosome cycle (GO:0046605)2.56829004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.55575104
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.28711666
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.94212761
4MYC_22102868_ChIP-Seq_BL_Human3.62340161
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24875290
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21461466
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97782850
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.89252488
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.68318338
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52985732
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37623060
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.28116845
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.19756124
14* E2F1_21310950_ChIP-Seq_MCF-7_Human2.08657986
15TCF7_22412390_ChIP-Seq_EML_Mouse2.07663562
16CIITA_25753668_ChIP-Seq_RAJI_Human2.00885262
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99718144
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.98634613
19AR_21909140_ChIP-Seq_LNCAP_Human1.93656928
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.91519364
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.90642297
22VDR_21846776_ChIP-Seq_THP-1_Human1.89523309
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.86427780
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86301977
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85089469
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83615951
27KDM2B_26808549_Chip-Seq_DND41_Human1.82116250
28ZFP281_27345836_Chip-Seq_ESCs_Mouse1.79412326
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78900850
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78577110
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74098966
32* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.73311391
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69506233
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65228189
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63700186
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62782566
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.60876679
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.58111004
39NANOG_21062744_ChIP-ChIP_HESCs_Human1.54289411
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53248325
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53201716
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51180051
43PKCTHETA_26484144_Chip-Seq_BREAST_Human1.48642334
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48380742
45* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47356122
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46745191
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43746247
48NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.42820783
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41431194
50KDM5A_27292631_Chip-Seq_BREAST_Human1.37129887
51POU5F1_16518401_ChIP-PET_MESCs_Mouse1.35608402
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34780069
53DCP1A_22483619_ChIP-Seq_HELA_Human1.34478681
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.33853206
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33539324
56XRN2_22483619_ChIP-Seq_HELA_Human1.31506828
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31369028
58* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31302591
59FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31190242
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31063046
61TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30494816
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29773247
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29313249
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29313249
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29313249
66* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29080002
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28937056
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28673141
69* ELK3_25401928_ChIP-Seq_HUVEC_Human1.28115921
70UTX_26944678_Chip-Seq_JUKART_Human1.28053696
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27078089
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26411354
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25684387
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.25378894
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23392839
76TTF2_22483619_ChIP-Seq_HELA_Human1.23277446
77NCOR1_26117541_ChIP-Seq_K562_Human1.23109418
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23103330
79* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21406883
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.21098336
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19569110
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18822740
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16983028
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16505177
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14804671
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14423477
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14151817
88GABP_19822575_ChIP-Seq_HepG2_Human1.12070063
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11209463
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09632964
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09529800
92MAF_26560356_Chip-Seq_TH1_Human1.07206460
93ATF3_27146783_Chip-Seq_COLON_Human1.05363450
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04980868
95KDM2B_26808549_Chip-Seq_K562_Human1.04297845
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.03780933
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01381752
98E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00691128
99SCL_19346495_ChIP-Seq_HPC-7_Human1.00135836
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00026876
101CHD1_26751641_Chip-Seq_LNCaP_Human0.98821790
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98618690
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98010339
104TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97702054
105ISL1_27105846_Chip-Seq_CPCs_Mouse0.96516161
106MYB_26560356_Chip-Seq_TH1_Human0.95625816
107* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91724323
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91410383
109SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90128494
110NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89054514
111ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87649779
112ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86738166
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86590240
114MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85601518
115ZNF263_19887448_ChIP-Seq_K562_Human0.85453423
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85264216
117CREB1_26743006_Chip-Seq_LNCaP_Human0.85225373
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84521969
119NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84095713
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82544504
121SOX17_20123909_ChIP-Seq_XEN_Mouse0.82110981
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81377941
123TFEB_21752829_ChIP-Seq_HELA_Human0.78001490
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77515149
125TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77006179
126FOXP3_21729870_ChIP-Seq_TREG_Human0.73909355
127RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.72572404
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71813769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.08919478
2MP0005076_abnormal_cell_differentiation3.07567062
3MP0003111_abnormal_nucleus_morphology3.00242891
4MP0008057_abnormal_DNA_replication2.90645229
5MP0010094_abnormal_chromosome_stability2.86476552
6MP0003077_abnormal_cell_cycle2.68486508
7MP0003705_abnormal_hypodermis_morpholog2.67349984
8MP0003693_abnormal_embryo_hatching2.67004794
9MP0010030_abnormal_orbit_morphology2.60708803
10MP0003890_abnormal_embryonic-extraembry2.42971755
11MP0004957_abnormal_blastocyst_morpholog2.40886977
12MP0003121_genomic_imprinting2.36560642
13MP0001730_embryonic_growth_arrest2.30377355
14MP0008877_abnormal_DNA_methylation2.29262178
15MP0002653_abnormal_ependyma_morphology2.28589913
16MP0002084_abnormal_developmental_patter2.08707962
17MP0005380_embryogenesis_phenotype2.05106394
18MP0001672_abnormal_embryogenesis/_devel2.05106394
19MP0009278_abnormal_bone_marrow2.03324090
20MP0000350_abnormal_cell_proliferation2.03197302
21MP0003123_paternal_imprinting2.00343027
22MP0002085_abnormal_embryonic_tissue1.98245683
23MP0008260_abnormal_autophagy1.96420703
24MP0003984_embryonic_growth_retardation1.95577105
25MP0002088_abnormal_embryonic_growth/wei1.93059992
26MP0001697_abnormal_embryo_size1.91098505
27MP0004197_abnormal_fetal_growth/weight/1.87306163
28MP0010307_abnormal_tumor_latency1.86918642
29MP0000566_synostosis1.84214507
30MP0003718_maternal_effect1.83411667
31MP0002086_abnormal_extraembryonic_tissu1.81557802
32MP0004185_abnormal_adipocyte_glucose1.77480706
33MP0008058_abnormal_DNA_repair1.76551319
34MP0008961_abnormal_basal_metabolism1.70836051
35MP0004264_abnormal_extraembryonic_tissu1.67736167
36MP0003122_maternal_imprinting1.60501212
37MP0001849_ear_inflammation1.59364116
38MP0003119_abnormal_digestive_system1.58449559
39MP0005409_darkened_coat_color1.58374139
40MP0008007_abnormal_cellular_replicative1.57940135
41MP0004808_abnormal_hematopoietic_stem1.56363161
42MP0009053_abnormal_anal_canal1.55405596
43MP0003567_abnormal_fetal_cardiomyocyte1.54767534
44MP0000569_abnormal_digit_pigmentation1.52046414
45MP0002080_prenatal_lethality1.48728118
46MP0003115_abnormal_respiratory_system1.47703123
47MP0003566_abnormal_cell_adhesion1.43345103
48MP0000733_abnormal_muscle_development1.42392178
49MP0002396_abnormal_hematopoietic_system1.40738609
50MP0001293_anophthalmia1.40573810
51MP0003935_abnormal_craniofacial_develop1.39335672
52MP0003941_abnormal_skin_development1.38083214
53MP0009697_abnormal_copulation1.37960075
54MP0009672_abnormal_birth_weight1.31790216
55MP0002925_abnormal_cardiovascular_devel1.30690719
56MP0005394_taste/olfaction_phenotype1.29858571
57MP0005499_abnormal_olfactory_system1.29858571
58MP0001545_abnormal_hematopoietic_system1.27412257
59MP0005397_hematopoietic_system_phenotyp1.27412257
60MP0003787_abnormal_imprinting1.24819244
61MP0008932_abnormal_embryonic_tissue1.22762861
62MP0000537_abnormal_urethra_morphology1.22665528
63MP0002233_abnormal_nose_morphology1.21784617
64MP0000428_abnormal_craniofacial_morphol1.21286895
65MP0001915_intracranial_hemorrhage1.21122399
66MP0004233_abnormal_muscle_weight1.20703751
67MP0005023_abnormal_wound_healing1.19324378
68MP0009703_decreased_birth_body1.19193587
69MP0000678_abnormal_parathyroid_gland1.16894703
70MP0008995_early_reproductive_senescence1.15086842
71MP0003937_abnormal_limbs/digits/tail_de1.14151876
72MP0002249_abnormal_larynx_morphology1.11057609
73MP0003861_abnormal_nervous_system1.10868722
74MP0000432_abnormal_head_morphology1.09404886
75MP0008789_abnormal_olfactory_epithelium1.09313619
76MP0002932_abnormal_joint_morphology1.07004292
77MP0002697_abnormal_eye_size1.04338134
78MP0000313_abnormal_cell_death1.02107258
79MP0004133_heterotaxia1.01223782
80MP0002092_abnormal_eye_morphology0.99939747
81MP0000703_abnormal_thymus_morphology0.99509784
82MP0003385_abnormal_body_wall0.96165344
83MP0005623_abnormal_meninges_morphology0.95792821
84MP0002210_abnormal_sex_determination0.94857699
85MP0000266_abnormal_heart_morphology0.94666185
86MP0002081_perinatal_lethality0.94459968
87MP0005187_abnormal_penis_morphology0.94153614
88MP0002116_abnormal_craniofacial_bone0.92590819
89MP0003698_abnormal_male_reproductive0.90933424
90MP0002877_abnormal_melanocyte_morpholog0.90669186
91MP0002161_abnormal_fertility/fecundity0.90449788
92MP0002796_impaired_skin_barrier0.89984055
93MP0010630_abnormal_cardiac_muscle0.89932697
94MP0005621_abnormal_cell_physiology0.88412845
95MP0005666_abnormal_adipose_tissue0.88320897
96MP0003091_abnormal_cell_migration0.86217449
97MP0008770_decreased_survivor_rate0.85737895
98MP0003943_abnormal_hepatobiliary_system0.85436659
99MP0003172_abnormal_lysosome_physiology0.85186838
100MP0002019_abnormal_tumor_incidence0.85108656
101MP0003699_abnormal_female_reproductive0.85061435
102MP0001145_abnormal_male_reproductive0.84795177
103MP0001929_abnormal_gametogenesis0.84753556
104MP0002111_abnormal_tail_morphology0.84301712
105MP0003755_abnormal_palate_morphology0.83595110
106MP0003283_abnormal_digestive_organ0.82888226
107MP0000358_abnormal_cell_content/0.82160787
108MP0005248_abnormal_Harderian_gland0.81501763
109MP0003183_abnormal_peptide_metabolism0.81233097
110MP0001286_abnormal_eye_development0.81075943
111MP0000534_abnormal_ureter_morphology0.80351423
112MP0005451_abnormal_body_composition0.80038329
113MP0000490_abnormal_crypts_of0.79263746
114MP0005384_cellular_phenotype0.78629178
115MP0003942_abnormal_urinary_system0.77120643
116MP0002152_abnormal_brain_morphology0.76838176
117MP0005501_abnormal_skin_physiology0.76302653
118MP0000653_abnormal_sex_gland0.74353512
119MP0003786_premature_aging0.74087567
120MP0006138_congestive_heart_failure0.73889963
121MP0002089_abnormal_postnatal_growth/wei0.73205241
122MP0001340_abnormal_eyelid_morphology0.72553936
123MP0000778_abnormal_nervous_system0.72390672
124MP0003300_gastrointestinal_ulcer0.71289860
125MP0002114_abnormal_axial_skeleton0.70111045
126MP0002282_abnormal_trachea_morphology0.69271711
127MP0006292_abnormal_olfactory_placode0.68358768
128MP0001614_abnormal_blood_vessel0.67842226

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.61810347
2Abnormality of cochlea (HP:0000375)3.70564303
3Ependymoma (HP:0002888)3.46169701
4Abnormality of the fingertips (HP:0001211)3.39543898
5Short 4th metacarpal (HP:0010044)3.39324032
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.39324032
7Long eyelashes (HP:0000527)3.27666131
8Trigonocephaly (HP:0000243)3.14319063
9Abnormality of the astrocytes (HP:0100707)3.13075925
10Astrocytoma (HP:0009592)3.13075925
11Increased nuchal translucency (HP:0010880)3.12661310
12Volvulus (HP:0002580)3.12428570
13Cortical dysplasia (HP:0002539)3.02749086
14Deep palmar crease (HP:0006191)2.89947709
15Hyperacusis (HP:0010780)2.88984522
16Abnormality of the phalanges of the hallux (HP:0010057)2.86096977
17Neoplasm of the oral cavity (HP:0100649)2.76691594
18Renal duplication (HP:0000075)2.74943432
19Abnormality of the labia minora (HP:0012880)2.74587063
20Overlapping toe (HP:0001845)2.72212091
21Morphological abnormality of the inner ear (HP:0011390)2.71775958
22Diastasis recti (HP:0001540)2.69974440
23Urethral obstruction (HP:0000796)2.67101124
24Medulloblastoma (HP:0002885)2.66098788
25Heterotopia (HP:0002282)2.59615510
26Shallow orbits (HP:0000586)2.58166618
27Hypoplasia of the capital femoral epiphysis (HP:0003090)2.58127693
28Facial cleft (HP:0002006)2.56150628
29Abnormality of the 4th metacarpal (HP:0010012)2.56093370
30Macroorchidism (HP:0000053)2.51642069
31Glioma (HP:0009733)2.49612147
32Ectopic kidney (HP:0000086)2.48223235
33Facial hemangioma (HP:0000329)2.48053395
34Birth length less than 3rd percentile (HP:0003561)2.46960299
35Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.46436092
36Absent epiphyses (HP:0010577)2.46436092
37Abnormality of the calcaneus (HP:0008364)2.43610508
38Prominent nose (HP:0000448)2.42037352
39Nephroblastoma (Wilms tumor) (HP:0002667)2.41129938
40Patellar aplasia (HP:0006443)2.39209541
41Proximal placement of thumb (HP:0009623)2.38572003
42Broad thumb (HP:0011304)2.38350959
43Deviation of the thumb (HP:0009603)2.37029927
44Renovascular hypertension (HP:0100817)2.32429433
45Abnormal number of incisors (HP:0011064)2.30942052
46Selective tooth agenesis (HP:0001592)2.24595170
47Embryonal renal neoplasm (HP:0011794)2.23925060
48Vertebral arch anomaly (HP:0008438)2.23014630
49Skull defect (HP:0001362)2.22431029
50Chin dimple (HP:0010751)2.20244499
51Colon cancer (HP:0003003)2.20024657
52Cutis marmorata (HP:0000965)2.18979013
53Anal stenosis (HP:0002025)2.18915069
54Aplasia/Hypoplasia of the patella (HP:0006498)2.16882032
55Shawl scrotum (HP:0000049)2.16269376
56Skin tags (HP:0010609)2.16155129
57Sparse lateral eyebrow (HP:0005338)2.15912221
58Broad distal phalanx of finger (HP:0009836)2.15260584
59Oligodactyly (HP:0012165)2.12769778
60Hepatoblastoma (HP:0002884)2.12378539
61Meckel diverticulum (HP:0002245)2.11696122
62Neoplasm of striated muscle (HP:0009728)2.11527154
63Duplication of thumb phalanx (HP:0009942)2.10320170
64Abnormal lung lobation (HP:0002101)2.05938153
65Abnormality of the distal phalanx of the thumb (HP:0009617)2.05400462
66Elfin facies (HP:0004428)2.04630179
67Broad palm (HP:0001169)2.03899480
68Broad phalanges of the hand (HP:0009768)2.03698213
69Obsessive-compulsive behavior (HP:0000722)2.02256711
70Gastrointestinal carcinoma (HP:0002672)2.00416603
71Malignant gastrointestinal tract tumors (HP:0006749)2.00416603
72Rib fusion (HP:0000902)1.99593696
73Megalocornea (HP:0000485)1.98497140
74Pseudobulbar signs (HP:0002200)1.97235056
75Narrow palate (HP:0000189)1.95969597
76Metaphyseal cupping (HP:0003021)1.94828822
77Abnormality of the ileum (HP:0001549)1.93296419
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.92489652
79Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92338519
80Irregular epiphyses (HP:0010582)1.91696684
81Small epiphyses (HP:0010585)1.90711935
82High anterior hairline (HP:0009890)1.90339578
83Abnormality of the preputium (HP:0100587)1.90177645
84Impulsivity (HP:0100710)1.89346381
85Genu recurvatum (HP:0002816)1.89106373
86Cerebral aneurysm (HP:0004944)1.87672196
87Broad finger (HP:0001500)1.87379571
88Pointed chin (HP:0000307)1.86808134
89Truncal obesity (HP:0001956)1.86508916
90Papillary thyroid carcinoma (HP:0002895)1.85209427
91Preauricular skin tag (HP:0000384)1.84160707
92Abnormality of the diencephalon (HP:0010662)1.83855388
93Abnormality of the lower motor neuron (HP:0002366)1.83766028
94Embryonal neoplasm (HP:0002898)1.83436072
95Abnormality of the carotid arteries (HP:0005344)1.82335009
96Aplasia/Hypoplasia of the uvula (HP:0010293)1.81720757
97Hand muscle atrophy (HP:0009130)1.81704099
98Abdominal situs inversus (HP:0003363)1.81679944
99Abnormality of abdominal situs (HP:0011620)1.81679944
100Insomnia (HP:0100785)1.81101937
101Bowel diverticulosis (HP:0005222)1.80596261
102Breast hypoplasia (HP:0003187)1.79638597
103Sandal gap (HP:0001852)1.79018439
104High pitched voice (HP:0001620)1.78979094
105Atresia of the external auditory canal (HP:0000413)1.78513350
106Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78136519
107Chromsome breakage (HP:0040012)1.77520753
108Capillary hemangiomas (HP:0005306)1.77436758
109Abnormality of chromosome segregation (HP:0002916)1.76492919
110Enlarged penis (HP:0000040)1.76402225
111Disproportionate tall stature (HP:0001519)1.76275229
112Hypopigmentation of the fundus (HP:0007894)1.75368721
113Spina bifida occulta (HP:0003298)1.75304359
114Leiomyosarcoma (HP:0100243)1.75281688
115Uterine leiomyosarcoma (HP:0002891)1.75281688
116Peripheral hypomyelination (HP:0007182)1.75192923
117Wrist flexion contracture (HP:0001239)1.75063291
118Generalized hypotonia (HP:0001290)1.74774217
119Overriding aorta (HP:0002623)1.74478845
120Abnormality of the intervertebral disk (HP:0005108)1.73793151
121Duodenal stenosis (HP:0100867)1.73608476
122Small intestinal stenosis (HP:0012848)1.73608476
123Long palpebral fissure (HP:0000637)1.72540426
124Supernumerary ribs (HP:0005815)1.72341271
125Tracheomalacia (HP:0002779)1.72249211
126Abnormality of the salivary glands (HP:0010286)1.72068661
127Transitional cell carcinoma of the bladder (HP:0006740)1.72016010
128Absent septum pellucidum (HP:0001331)1.71991721
129Microglossia (HP:0000171)1.71505600
130Short 5th finger (HP:0009237)1.70819996
131Abnormality of lateral ventricle (HP:0030047)1.70664535
132Neoplasm of the heart (HP:0100544)1.70400918
133Rhabdomyosarcoma (HP:0002859)1.69949605
134Absent radius (HP:0003974)1.69847524
135Thin ribs (HP:0000883)1.69465064
136Calcaneovalgus deformity (HP:0001848)1.69215914
137Cafe-au-lait spot (HP:0000957)1.69186850
138Broad phalanx (HP:0006009)1.69171597
139Patellar dislocation (HP:0002999)1.68858176
140Depressed nasal tip (HP:0000437)1.68691642
141Attention deficit hyperactivity disorder (HP:0007018)1.68495474
142Short philtrum (HP:0000322)1.67669215
143Abnormality of the septum pellucidum (HP:0007375)1.67334637
144Abnormality of chromosome stability (HP:0003220)1.66296780
145Short humerus (HP:0005792)1.66085271
146Smooth philtrum (HP:0000319)1.65767129
147Limited elbow extension (HP:0001377)1.65560059
148Deep philtrum (HP:0002002)1.65541999
149Lip pit (HP:0100267)1.64028648
150Septate vagina (HP:0001153)1.63913415
151Choanal atresia (HP:0000453)1.63410738
152Aneurysm (HP:0002617)1.62839660
153Midline defect of the nose (HP:0004122)1.62324672
154Carpal bone hypoplasia (HP:0001498)1.62197665
155Deviation of the hallux (HP:0010051)1.62129494
156Poor speech (HP:0002465)1.60313249
157Myelomeningocele (HP:0002475)1.60188976
158Split hand (HP:0001171)1.58099583
159Flared metaphyses (HP:0003015)1.57987782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.73886345
2EEF2K3.27313836
3CDC73.10355900
4LATS12.71574467
5MAP3K102.67030375
6BRD42.57383187
7NEK22.39790073
8ICK2.31062120
9SMG12.06837351
10LATS21.98235826
11STK101.82028135
12EIF2AK11.80737983
13WNK11.79348123
14CAMK1D1.77989983
15RIPK11.73784647
16MTOR1.72733302
17CAMK1G1.70504082
18TTK1.64482088
19TRIB31.55383113
20SIK11.48629990
21CDK71.45910226
22STK31.42544805
23ERN11.40954416
24DMPK1.35153599
25SIK31.34901435
26TAOK11.34607312
27BUB11.32906269
28CHEK21.32013616
29RPS6KB21.31249562
30BRAF1.29928641
31CHEK11.28691134
32SIK21.25933500
33FGFR41.22848514
34PDGFRA1.14942812
35ATR1.13875627
36CDK41.13814469
37KSR11.12299538
38PLK11.10944909
39PRPF4B1.09525148
40MELK1.09297697
41TYRO31.07002482
42PASK1.03381244
43NEK11.00987520
44CDK60.96958637
45MAP3K60.94851069
46CDK20.94620622
47ALK0.94471251
48CDK90.93686509
49PRKD30.89237013
50EPHA20.88553596
51PKN20.87752002
52SRPK10.87364841
53MAP3K80.87236417
54TSSK60.85104026
55BMX0.82137539
56PAK40.80185016
57SGK30.80163926
58AURKB0.79761710
59PNCK0.78283973
60NTRK30.78150528
61WEE10.77549655
62FGFR10.77342478
63PLK40.77179295
64TAF10.76989613
65DYRK30.76815080
66PTK20.76262248
67MAP4K10.76157530
68ATM0.76129497
69IRAK20.75449935
70CDK190.75303863
71BRSK10.75175851
72FGFR20.74634417
73RPS6KA40.73259502
74YES10.71887402
75BRSK20.71783100
76TGFBR10.71549445
77CDK10.70605803
78PLK30.68819281
79CHUK0.67613681
80CDC42BPA0.65750420
81MET0.63896569
82CDK11A0.62409708
83PDGFRB0.62002068
84PBK0.61760336
85KSR20.61403813
86MAPKAPK30.60936299
87RAF10.60477448
88PAK60.59924031
89MARK20.59727352
90AURKA0.59252676
91MAPK140.58560175
92STK40.57540715
93PAK20.57204820
94CDK150.57130294
95PIM10.56136504
96ERBB40.55958083
97CDK180.55325149
98TTN0.53658392
99AKT20.52960133
100GSK3B0.51949980
101MAPK10.51915449
102TESK20.51228359
103NEK60.50439775
104BLK0.48882750
105MAP3K90.48594066
106DYRK1B0.48230362
107PTK60.48032434
108ACVR1B0.45847381
109SGK20.45633285
110MAPK90.45473387
111CDK140.43629851
112STK38L0.43092936
113AKT10.43045098
114SCYL20.42897253
115MAPK100.41216271
116CSNK1E0.40696732
117DYRK20.40484692
118ERBB20.40278529
119RPS6KA10.40018699
120MKNK10.39283928
121DDR20.39202983
122NUAK10.38521594
123TRIM280.38462650
124MAPK110.38092909
125TAOK20.38050069
126PRKDC0.37937764
127EPHB20.37628278
128LRRK20.37054879
129PRKG20.36576229
130PRKAA10.36382867
131CSNK1D0.36278879
132FGFR30.35915120
133STK380.34974270

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.73119803
2RNA transport_Homo sapiens_hsa030132.53466799
3mRNA surveillance pathway_Homo sapiens_hsa030152.20330273
4Spliceosome_Homo sapiens_hsa030402.08647891
5Lysine degradation_Homo sapiens_hsa003102.01138029
6Notch signaling pathway_Homo sapiens_hsa043301.98217571
7DNA replication_Homo sapiens_hsa030301.88003100
8Mismatch repair_Homo sapiens_hsa034301.83275110
9Basal cell carcinoma_Homo sapiens_hsa052171.77299393
10MicroRNAs in cancer_Homo sapiens_hsa052061.75269234
11Adherens junction_Homo sapiens_hsa045201.71139905
12mTOR signaling pathway_Homo sapiens_hsa041501.68737992
13Base excision repair_Homo sapiens_hsa034101.68019121
14Chronic myeloid leukemia_Homo sapiens_hsa052201.64194871
15Colorectal cancer_Homo sapiens_hsa052101.62538077
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.59750285
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.57832623
18Hippo signaling pathway_Homo sapiens_hsa043901.55272310
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.54585478
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51312823
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49049376
22p53 signaling pathway_Homo sapiens_hsa041151.47526305
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46681271
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45764542
25RNA degradation_Homo sapiens_hsa030181.39669437
26Biosynthesis of amino acids_Homo sapiens_hsa012301.33736545
27Endometrial cancer_Homo sapiens_hsa052131.32533610
28Oocyte meiosis_Homo sapiens_hsa041141.32038993
29Hedgehog signaling pathway_Homo sapiens_hsa043401.30644395
30Pancreatic cancer_Homo sapiens_hsa052121.30050539
31Small cell lung cancer_Homo sapiens_hsa052221.29284824
32HTLV-I infection_Homo sapiens_hsa051661.27510562
33TGF-beta signaling pathway_Homo sapiens_hsa043501.26024458
34Non-homologous end-joining_Homo sapiens_hsa034501.25869247
35One carbon pool by folate_Homo sapiens_hsa006701.20355338
36Dorso-ventral axis formation_Homo sapiens_hsa043201.18320260
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16406255
38Fanconi anemia pathway_Homo sapiens_hsa034601.16029815
39Viral carcinogenesis_Homo sapiens_hsa052031.12404025
40Acute myeloid leukemia_Homo sapiens_hsa052211.11778402
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.10485593
42Proteoglycans in cancer_Homo sapiens_hsa052051.09531487
43Herpes simplex infection_Homo sapiens_hsa051681.07949505
44Non-small cell lung cancer_Homo sapiens_hsa052231.07158895
45Epstein-Barr virus infection_Homo sapiens_hsa051691.03548955
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03104646
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02452671
48Viral myocarditis_Homo sapiens_hsa054161.02047193
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01926385
50Hepatitis B_Homo sapiens_hsa051611.01546493
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01000521
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.99207873
53Renal cell carcinoma_Homo sapiens_hsa052110.98098618
54Wnt signaling pathway_Homo sapiens_hsa043100.97531627
55Prostate cancer_Homo sapiens_hsa052150.96949287
56Bladder cancer_Homo sapiens_hsa052190.96899307
57Steroid biosynthesis_Homo sapiens_hsa001000.95776181
58Glioma_Homo sapiens_hsa052140.92114569
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92068518
60Pathways in cancer_Homo sapiens_hsa052000.91335642
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90846416
62VEGF signaling pathway_Homo sapiens_hsa043700.90713904
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89506595
64Thyroid cancer_Homo sapiens_hsa052160.87571452
65Nucleotide excision repair_Homo sapiens_hsa034200.87237432
66Basal transcription factors_Homo sapiens_hsa030220.86340673
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85487096
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.83622609
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80844868
70FoxO signaling pathway_Homo sapiens_hsa040680.76353215
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74904213
72Homologous recombination_Homo sapiens_hsa034400.73139570
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73100034
74B cell receptor signaling pathway_Homo sapiens_hsa046620.72109813
75Focal adhesion_Homo sapiens_hsa045100.72069605
76Prolactin signaling pathway_Homo sapiens_hsa049170.71838383
77ErbB signaling pathway_Homo sapiens_hsa040120.71377010
78Estrogen signaling pathway_Homo sapiens_hsa049150.71355692
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70501587
80Type II diabetes mellitus_Homo sapiens_hsa049300.70497382
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69554184
82AMPK signaling pathway_Homo sapiens_hsa041520.69520366
83HIF-1 signaling pathway_Homo sapiens_hsa040660.68666429
84Insulin resistance_Homo sapiens_hsa049310.68327530
85Antigen processing and presentation_Homo sapiens_hsa046120.65186881
86Influenza A_Homo sapiens_hsa051640.65144519
87Gap junction_Homo sapiens_hsa045400.64932585
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64535791
89Shigellosis_Homo sapiens_hsa051310.63965282
90Pentose phosphate pathway_Homo sapiens_hsa000300.63487288
91Apoptosis_Homo sapiens_hsa042100.63017661
92Toxoplasmosis_Homo sapiens_hsa051450.61736417
93Carbon metabolism_Homo sapiens_hsa012000.59224735
94Insulin signaling pathway_Homo sapiens_hsa049100.58534054
95Choline metabolism in cancer_Homo sapiens_hsa052310.58332947
96Melanoma_Homo sapiens_hsa052180.57000610
97RNA polymerase_Homo sapiens_hsa030200.56665003
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56210987
99T cell receptor signaling pathway_Homo sapiens_hsa046600.55985588
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55808466
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54802489
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53585216
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51894952
104MAPK signaling pathway_Homo sapiens_hsa040100.51473266
105Rap1 signaling pathway_Homo sapiens_hsa040150.51272254
106Pyrimidine metabolism_Homo sapiens_hsa002400.50705379
107Tight junction_Homo sapiens_hsa045300.49853087
108Glucagon signaling pathway_Homo sapiens_hsa049220.49287130
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.48798736
110TNF signaling pathway_Homo sapiens_hsa046680.48642948
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.48298249
112Axon guidance_Homo sapiens_hsa043600.47990772
113Melanogenesis_Homo sapiens_hsa049160.46350845
114Circadian rhythm_Homo sapiens_hsa047100.44984795
115Inositol phosphate metabolism_Homo sapiens_hsa005620.44016546
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43290287
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42822443
118Vitamin B6 metabolism_Homo sapiens_hsa007500.42347268
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42004691
120Measles_Homo sapiens_hsa051620.40081129
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38675828
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.38611092
123N-Glycan biosynthesis_Homo sapiens_hsa005100.36520430
124Sulfur relay system_Homo sapiens_hsa041220.35715345
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33948991

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