SAP30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.80068911
2cotranslational protein targeting to membrane (GO:0006613)4.74849959
3protein targeting to ER (GO:0045047)4.70178374
4establishment of protein localization to endoplasmic reticulum (GO:0072599)4.54870307
5cellular protein complex disassembly (GO:0043624)4.40541971
6protein localization to endoplasmic reticulum (GO:0070972)4.33930411
7viral life cycle (GO:0019058)4.31379710
8DNA deamination (GO:0045006)4.29238427
9DNA topological change (GO:0006265)4.20235147
10DNA strand elongation involved in DNA replication (GO:0006271)4.16305867
11mitotic metaphase plate congression (GO:0007080)4.04676490
12protein localization to kinetochore (GO:0034501)4.03274318
13protein complex disassembly (GO:0043241)4.03046118
14telomere maintenance via semi-conservative replication (GO:0032201)3.99537247
15DNA strand elongation (GO:0022616)3.93591921
16DNA replication initiation (GO:0006270)3.90965028
17macromolecular complex disassembly (GO:0032984)3.82073278
18telomere maintenance via recombination (GO:0000722)3.68723350
19heterochromatin organization (GO:0070828)3.68104078
20protein localization to chromosome, centromeric region (GO:0071459)3.62945778
21mitotic nuclear envelope disassembly (GO:0007077)3.62843980
22mitotic sister chromatid cohesion (GO:0007064)3.59714564
23DNA replication checkpoint (GO:0000076)3.59086633
24folic acid-containing compound biosynthetic process (GO:0009396)3.57536591
25DNA unwinding involved in DNA replication (GO:0006268)3.54624164
26kinetochore organization (GO:0051383)3.49217164
27mitotic chromosome condensation (GO:0007076)3.47169047
28metaphase plate congression (GO:0051310)3.46006384
29translation (GO:0006412)3.45267683
30DNA replication-dependent nucleosome organization (GO:0034723)3.44932769
31DNA replication-dependent nucleosome assembly (GO:0006335)3.44932769
32nuclear-transcribed mRNA catabolic process (GO:0000956)3.44274697
33mitotic recombination (GO:0006312)3.44006430
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.42783322
35nuclear pore organization (GO:0006999)3.42761451
36protein K6-linked ubiquitination (GO:0085020)3.42669238
37mitotic sister chromatid segregation (GO:0000070)3.40082481
38kinetochore assembly (GO:0051382)3.36473989
39maturation of 5.8S rRNA (GO:0000460)3.36362822
40chromosome condensation (GO:0030261)3.35919645
41membrane disassembly (GO:0030397)3.35555620
42nuclear envelope disassembly (GO:0051081)3.35555620
43chromatin remodeling at centromere (GO:0031055)3.33462630
44nuclear pore complex assembly (GO:0051292)3.31681048
45formation of translation preinitiation complex (GO:0001731)3.31461848
46mRNA catabolic process (GO:0006402)3.30195910
47establishment of chromosome localization (GO:0051303)3.29568861
48protein targeting to membrane (GO:0006612)3.28945340
49CENP-A containing nucleosome assembly (GO:0034080)3.27933234
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.26377400
51regulation of helicase activity (GO:0051095)3.25157678
52regulation of double-strand break repair via homologous recombination (GO:0010569)3.24414031
53dosage compensation (GO:0007549)3.23383797
54deoxyribonucleotide biosynthetic process (GO:0009263)3.20710248
55chromatin assembly (GO:0031497)3.20583209
56RNA catabolic process (GO:0006401)3.19534250
57meiotic chromosome segregation (GO:0045132)3.19454382
58ribosome assembly (GO:0042255)3.17912070
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17895757
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.17554276
61regulation of DNA endoreduplication (GO:0032875)3.16392739
62attachment of spindle microtubules to kinetochore (GO:0008608)3.15985637
63regulation of sister chromatid cohesion (GO:0007063)3.13640483
64DNA packaging (GO:0006323)3.12228429
65ribosomal small subunit assembly (GO:0000028)3.11171353
66deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10828281
67negative regulation of RNA splicing (GO:0033119)3.09654673
68telomere maintenance via telomere lengthening (GO:0010833)3.08812947
69maturation of SSU-rRNA (GO:0030490)3.08359308
70viral transcription (GO:0019083)3.07135959
71nucleotide-excision repair, DNA gap filling (GO:0006297)3.06181345
72DNA replication-independent nucleosome assembly (GO:0006336)3.05533467
73DNA replication-independent nucleosome organization (GO:0034724)3.05533467
74positive regulation of chromosome segregation (GO:0051984)3.05049883
75resolution of meiotic recombination intermediates (GO:0000712)3.04676510
76sister chromatid segregation (GO:0000819)3.04525475
77cellular component biogenesis (GO:0044085)3.03833743
78translational termination (GO:0006415)3.03830223
79replication fork processing (GO:0031297)3.03641761
80regulation of spindle organization (GO:0090224)3.01715004
81establishment of protein localization to mitochondrial membrane (GO:0090151)3.01305192
82negative regulation of mRNA processing (GO:0050686)3.00714064
83ATP-dependent chromatin remodeling (GO:0043044)2.99197442
84chaperone-mediated protein transport (GO:0072321)2.97927705
85ribosomal large subunit biogenesis (GO:0042273)2.95741941
86nucleobase-containing small molecule interconversion (GO:0015949)2.95696320
87mitotic spindle checkpoint (GO:0071174)2.95001562
88ribosome biogenesis (GO:0042254)2.92493958
89nucleosome assembly (GO:0006334)2.89691249
90somatic hypermutation of immunoglobulin genes (GO:0016446)2.87770367
91somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87770367
92translational initiation (GO:0006413)2.84380759
93ribonucleoprotein complex biogenesis (GO:0022613)2.83305354
94chromatin assembly or disassembly (GO:0006333)2.82863628
95positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76800984
96positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76800984
97positive regulation of mitotic sister chromatid separation (GO:1901970)2.76800984
98translational elongation (GO:0006414)2.76225482
99histone exchange (GO:0043486)2.74567376
100nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.74208617
101rRNA processing (GO:0006364)2.73048727
102regulation of chromosome segregation (GO:0051983)2.72574066
103chromosome segregation (GO:0007059)2.71711221
104negative regulation of chromosome segregation (GO:0051985)2.68959732
105regulation of posttranscriptional gene silencing (GO:0060147)2.68227331
106regulation of gene silencing by miRNA (GO:0060964)2.68227331
107regulation of gene silencing by RNA (GO:0060966)2.68227331
108mismatch repair (GO:0006298)2.68152231
109regulation of centrosome cycle (GO:0046605)2.68069837
110regulation of histone H3-K9 methylation (GO:0051570)2.67744924
111nuclear envelope organization (GO:0006998)2.66452524
112ribosomal small subunit biogenesis (GO:0042274)2.66449240
113base-excision repair (GO:0006284)2.66396773
114rRNA metabolic process (GO:0016072)2.63604283
115immunoglobulin mediated immune response (GO:0016064)2.63397488
116B cell mediated immunity (GO:0019724)2.62983077
117regulation of mitotic spindle organization (GO:0060236)2.62946852
118DNA geometric change (GO:0032392)2.62929244
119DNA duplex unwinding (GO:0032508)2.62348106
120spindle checkpoint (GO:0031577)2.61708417
121IMP metabolic process (GO:0046040)2.61341697
122regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.61188659
123IMP biosynthetic process (GO:0006188)2.60931291
124protein localization to chromosome (GO:0034502)2.60555966
125nucleobase biosynthetic process (GO:0046112)2.60331566
126DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.59244367
127pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58104337
128regulation of mitotic metaphase/anaphase transition (GO:0030071)2.57633229
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.57218827
130spliceosomal snRNP assembly (GO:0000387)2.52860886
131negative regulation of mitotic sister chromatid separation (GO:2000816)2.52465696
132negative regulation of mitotic sister chromatid segregation (GO:0033048)2.52465696
133negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.52465696
134negative regulation of sister chromatid segregation (GO:0033046)2.52465696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.03252617
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.39804713
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.73007583
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36216577
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17911991
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17767846
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56768747
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47965870
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37782303
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.31607394
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.15262231
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12423947
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09232283
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.08184364
15* EST1_17652178_ChIP-ChIP_JURKAT_Human2.03681488
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01292231
17* ETS1_20019798_ChIP-Seq_JURKAT_Human1.99570910
18XRN2_22483619_ChIP-Seq_HELA_Human1.96041639
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.90801208
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87993818
21AR_21909140_ChIP-Seq_LNCAP_Human1.86723442
22NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86155676
23VDR_23849224_ChIP-Seq_CD4+_Human1.85064712
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84700062
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82288878
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82160367
27MYC_22102868_ChIP-Seq_BL_Human1.81177985
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80542249
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79586397
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73137790
31* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69837263
32DCP1A_22483619_ChIP-Seq_HELA_Human1.67638220
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.66733823
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59341212
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59280743
36VDR_21846776_ChIP-Seq_THP-1_Human1.56158956
37GABP_19822575_ChIP-Seq_HepG2_Human1.56116105
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54850981
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53918300
40TTF2_22483619_ChIP-Seq_HELA_Human1.53024161
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51119377
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49444715
43FOXP3_21729870_ChIP-Seq_TREG_Human1.45741854
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44713144
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44602687
46KDM5A_27292631_Chip-Seq_BREAST_Human1.39254372
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39218691
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39202305
49* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37662619
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.36014886
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35809172
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35173584
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32093083
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31589079
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30876630
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30876630
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30876630
58ELK1_19687146_ChIP-ChIP_HELA_Human1.30366494
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29742215
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28682354
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28505209
62* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27680564
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27197937
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25525355
65SPI1_23547873_ChIP-Seq_NB4_Human1.25503769
66TFEB_21752829_ChIP-Seq_HELA_Human1.24426350
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23817880
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22955923
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22544048
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22210065
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21135769
72* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20211462
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.17558758
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.17194585
75* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15907577
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15734806
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15298548
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14638949
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14484021
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14483675
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14210123
82CIITA_25753668_ChIP-Seq_RAJI_Human1.13853726
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12698476
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12667440
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09462440
86* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08387169
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07961337
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07523902
89* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07217947
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06832964
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06308310
92* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03537374
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.03283642
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02839160
95ZNF263_19887448_ChIP-Seq_K562_Human1.02806849
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.02233425
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02216262
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00712093
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00297550
100* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98535546
101NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95703980
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95526935
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94937653
104* SOX2_16153702_ChIP-ChIP_HESCs_Human0.94296736
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94237265
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94196690
107* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94015745
108NOTCH1_21737748_ChIP-Seq_TLL_Human0.93878103
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93765033
110BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92708286
111* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92196025
112SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91923548
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91582133
114MYC_18940864_ChIP-ChIP_HL60_Human0.91289104
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89606536
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88590691
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87599961
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.87176679
119ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85862147
120IRF1_19129219_ChIP-ChIP_H3396_Human0.85792312
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83541693
122CHD1_26751641_Chip-Seq_LNCaP_Human0.79957415
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77831354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.52751969
2MP0010094_abnormal_chromosome_stability3.84100323
3MP0003111_abnormal_nucleus_morphology3.65260155
4MP0004957_abnormal_blastocyst_morpholog3.57735686
5MP0008057_abnormal_DNA_replication3.48836775
6MP0003077_abnormal_cell_cycle3.40584123
7MP0009379_abnormal_foot_pigmentation3.26977095
8MP0008058_abnormal_DNA_repair2.40537637
9MP0008007_abnormal_cellular_replicative2.32341202
10MP0010307_abnormal_tumor_latency2.30492836
11MP0010352_gastrointestinal_tract_polyps2.15646956
12MP0000490_abnormal_crypts_of2.08583611
13MP0003718_maternal_effect2.07376801
14MP0008932_abnormal_embryonic_tissue2.05860553
15MP0009278_abnormal_bone_marrow1.99820111
16MP0002163_abnormal_gland_morphology1.98221177
17MP0000350_abnormal_cell_proliferation1.94818475
18MP0001545_abnormal_hematopoietic_system1.91286576
19MP0005397_hematopoietic_system_phenotyp1.91286576
20MP0005076_abnormal_cell_differentiation1.79950332
21MP0001730_embryonic_growth_arrest1.77641883
22MP0002396_abnormal_hematopoietic_system1.75822755
23MP0003436_decreased_susceptibility_to1.67682910
24MP0001835_abnormal_antigen_presentation1.66014524
25MP0002653_abnormal_ependyma_morphology1.63802366
26MP0009333_abnormal_splenocyte_physiolog1.55964137
27MP0002019_abnormal_tumor_incidence1.50906206
28MP0003786_premature_aging1.48665238
29MP0009785_altered_susceptibility_to1.45370573
30MP0001672_abnormal_embryogenesis/_devel1.44671166
31MP0005380_embryogenesis_phenotype1.44671166
32MP0001697_abnormal_embryo_size1.44235739
33MP0000858_altered_metastatic_potential1.41593315
34MP0000313_abnormal_cell_death1.39876312
35MP0009697_abnormal_copulation1.37543615
36MP0003303_peritoneal_inflammation1.35732717
37MP0002085_abnormal_embryonic_tissue1.34998223
38MP0003646_muscle_fatigue1.33302985
39MP0002398_abnormal_bone_marrow1.29700632
40MP0003123_paternal_imprinting1.28708102
41MP0000049_abnormal_middle_ear1.28344664
42MP0000685_abnormal_immune_system1.27796614
43MP0004808_abnormal_hematopoietic_stem1.27448505
44MP0006292_abnormal_olfactory_placode1.26993630
45MP0002084_abnormal_developmental_patter1.24823238
46MP0002086_abnormal_extraembryonic_tissu1.23844856
47MP0003984_embryonic_growth_retardation1.23536394
48MP0008789_abnormal_olfactory_epithelium1.23414495
49MP0002080_prenatal_lethality1.23232383
50MP0003937_abnormal_limbs/digits/tail_de1.22924592
51MP0009053_abnormal_anal_canal1.21909030
52MP0001529_abnormal_vocalization1.21054237
53MP0002088_abnormal_embryonic_growth/wei1.20698419
54MP0002452_abnormal_antigen_presenting1.20484926
55MP0005000_abnormal_immune_tolerance1.20113136
56MP0005025_abnormal_response_to1.19765933
57MP0002697_abnormal_eye_size1.18844700
58MP0000689_abnormal_spleen_morphology1.18511382
59MP0001286_abnormal_eye_development1.17726438
60MP0002092_abnormal_eye_morphology1.16888711
61MP0000678_abnormal_parathyroid_gland1.16834849
62MP0003448_altered_tumor_morphology1.16301697
63MP0006035_abnormal_mitochondrial_morpho1.15009064
64MP0010030_abnormal_orbit_morphology1.13747158
65MP0001800_abnormal_humoral_immune1.13716181
66MP0002722_abnormal_immune_system1.13447676
67MP0002148_abnormal_hypersensitivity_rea1.12446058
68MP0002160_abnormal_reproductive_system1.12067949
69MP0003186_abnormal_redox_activity1.11986133
70MP0003567_abnormal_fetal_cardiomyocyte1.11591335
71MP0008877_abnormal_DNA_methylation1.09503906
72MP0006082_CNS_inflammation1.08268235
73MP0003385_abnormal_body_wall1.08226276
74MP0005394_taste/olfaction_phenotype1.08220552
75MP0005499_abnormal_olfactory_system1.08220552
76MP0002006_tumorigenesis1.06615708
77MP0002405_respiratory_system_inflammati1.06368720
78MP0002419_abnormal_innate_immunity1.05168991
79MP0002723_abnormal_immune_serum1.04629316
80MP0001819_abnormal_immune_cell1.04485598
81MP0003763_abnormal_thymus_physiology1.03712806
82MP0003941_abnormal_skin_development1.03628132
83MP0002095_abnormal_skin_pigmentation1.03387149
84MP0002210_abnormal_sex_determination1.03304120
85MP0002420_abnormal_adaptive_immunity1.03175643
86MP0002429_abnormal_blood_cell1.03138939
87MP0001119_abnormal_female_reproductive1.02761742
88MP0001727_abnormal_embryo_implantation1.01979069
89MP0000716_abnormal_immune_system1.01772945
90MP0003755_abnormal_palate_morphology0.99147591
91MP0000703_abnormal_thymus_morphology0.98519573
92MP0001293_anophthalmia0.97680612
93MP0004197_abnormal_fetal_growth/weight/0.97653598
94MP0002111_abnormal_tail_morphology0.96359917
95MP0009250_abnormal_appendicular_skeleto0.96259055
96MP0003121_genomic_imprinting0.95443255
97MP0000371_diluted_coat_color0.88824266
98MP0003861_abnormal_nervous_system0.88222721
99MP0001915_intracranial_hemorrhage0.88053381
100MP0000428_abnormal_craniofacial_morphol0.87266552
101MP0005671_abnormal_response_to0.86851476
102MP0001853_heart_inflammation0.86408603
103MP0005174_abnormal_tail_pigmentation0.85575983
104MP0001145_abnormal_male_reproductive0.85498379
105MP0003890_abnormal_embryonic-extraembry0.84924315
106MP0002938_white_spotting0.84246176
107MP0003453_abnormal_keratinocyte_physiol0.83713684
108MP0003942_abnormal_urinary_system0.83364517
109MP0005023_abnormal_wound_healing0.82804534
110MP0010155_abnormal_intestine_physiology0.82337588
111MP0006036_abnormal_mitochondrial_physio0.81246032
112MP0005623_abnormal_meninges_morphology0.81139812
113MP0000631_abnormal_neuroendocrine_gland0.80359945
114MP0005379_endocrine/exocrine_gland_phen0.79884185
115MP0002233_abnormal_nose_morphology0.79562805
116MP0000653_abnormal_sex_gland0.79413451
117MP0002114_abnormal_axial_skeleton0.78945873
118MP0002102_abnormal_ear_morphology0.78310644
119MP0003315_abnormal_perineum_morphology0.77960769
120MP0005171_absent_coat_pigmentation0.77241481
121MP0001929_abnormal_gametogenesis0.77112366
122MP0005391_vision/eye_phenotype0.76578156
123MP0003935_abnormal_craniofacial_develop0.76542712
124MP0002132_abnormal_respiratory_system0.76403503
125MP0003566_abnormal_cell_adhesion0.75989130
126MP0005621_abnormal_cell_physiology0.75275256
127MP0002877_abnormal_melanocyte_morpholog0.74217116
128MP0009672_abnormal_birth_weight0.73660786
129MP0003656_abnormal_erythrocyte_physiolo0.72953270
130MP0005389_reproductive_system_phenotype0.72358546
131MP0002282_abnormal_trachea_morphology0.71519476
132MP0001845_abnormal_inflammatory_respons0.70612870
133MP0002177_abnormal_outer_ear0.70251511
134MP0003699_abnormal_female_reproductive0.70055000
135MP0000358_abnormal_cell_content/0.69724567
136MP0005384_cellular_phenotype0.68900722
137MP0003221_abnormal_cardiomyocyte_apopto0.68868300
138MP0003136_yellow_coat_color0.68078153
139MP0002161_abnormal_fertility/fecundity0.67712882
140MP0003698_abnormal_male_reproductive0.67397947
141MP0003705_abnormal_hypodermis_morpholog0.67059720
142MP0005501_abnormal_skin_physiology0.66942932
143MP0003828_pulmonary_edema0.66672859
144MP0002277_abnormal_respiratory_mucosa0.66198597
145MP0000015_abnormal_ear_pigmentation0.65564399
146MP0002116_abnormal_craniofacial_bone0.65510931
147MP0002009_preneoplasia0.64471919
148MP0005193_abnormal_anterior_eye0.62770220

Predicted human phenotypes

RankGene SetZ-score
1Agnosia (HP:0010524)3.90321930
2Chromsome breakage (HP:0040012)3.88701039
3Birth length less than 3rd percentile (HP:0003561)3.88143049
4Reticulocytopenia (HP:0001896)3.68601804
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.67069632
6Breast hypoplasia (HP:0003187)3.51865205
7Increased nuchal translucency (HP:0010880)3.32168624
8Patellar aplasia (HP:0006443)3.23847137
9Recurrent abscess formation (HP:0002722)3.17157425
10Aplasia/Hypoplasia of the patella (HP:0006498)3.04552672
11Abnormality of cells of the erythroid lineage (HP:0012130)2.91848393
12Short middle phalanx of the 5th finger (HP:0004220)2.91146548
13Abnormality of chromosome stability (HP:0003220)2.89960978
14Ependymoma (HP:0002888)2.83863056
15Eczematoid dermatitis (HP:0000976)2.83669675
16Horseshoe kidney (HP:0000085)2.82258805
17Abnormal number of erythroid precursors (HP:0012131)2.76960725
18Myelodysplasia (HP:0002863)2.75109006
19Broad distal phalanx of finger (HP:0009836)2.75101570
20Recurrent bacterial skin infections (HP:0005406)2.73524600
21Facial hemangioma (HP:0000329)2.71291480
22Absent thumb (HP:0009777)2.70362136
23Pustule (HP:0200039)2.68836994
24Oral leukoplakia (HP:0002745)2.68800364
25Rhabdomyosarcoma (HP:0002859)2.68498899
26Selective tooth agenesis (HP:0001592)2.68318025
27Abnormality of the preputium (HP:0100587)2.68107103
28Abnormality of the ileum (HP:0001549)2.67855290
29Medulloblastoma (HP:0002885)2.67292723
30Abnormality of the anterior horn cell (HP:0006802)2.67158365
31Degeneration of anterior horn cells (HP:0002398)2.67158365
32Poikiloderma (HP:0001029)2.64629462
33Absent radius (HP:0003974)2.63942151
34Abnormal mitochondria in muscle tissue (HP:0008316)2.62580894
35Amaurosis fugax (HP:0100576)2.60169689
36Meckel diverticulum (HP:0002245)2.59194017
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.58187743
38Mediastinal lymphadenopathy (HP:0100721)2.57355767
39Aplastic anemia (HP:0001915)2.55548483
40Acute necrotizing encephalopathy (HP:0006965)2.55292545
41Colon cancer (HP:0003003)2.52449905
42Overlapping toe (HP:0001845)2.49591596
43Abnormality of the carotid arteries (HP:0005344)2.48589219
44Nephroblastoma (Wilms tumor) (HP:0002667)2.47183427
45Microvesicular hepatic steatosis (HP:0001414)2.46447760
46Rib fusion (HP:0000902)2.44841518
47Carpal bone hypoplasia (HP:0001498)2.44452917
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.44429077
49Aplasia involving forearm bones (HP:0009822)2.43965271
50Absent forearm bone (HP:0003953)2.43965271
51Volvulus (HP:0002580)2.43914286
52Overriding aorta (HP:0002623)2.42468328
53Abnormality of the phalanges of the hallux (HP:0010057)2.38026177
54Pallor (HP:0000980)2.36229356
55Deep palmar crease (HP:0006191)2.34349519
56Embryonal renal neoplasm (HP:0011794)2.33784496
57Cleft eyelid (HP:0000625)2.29396345
58Duplication of thumb phalanx (HP:0009942)2.27995196
59Increased hepatocellular lipid droplets (HP:0006565)2.25657601
60Abnormality of reticulocytes (HP:0004312)2.24428867
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24289960
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24289960
63Abnormality of the duodenum (HP:0002246)2.24261806
64Premature graying of hair (HP:0002216)2.23733848
65Abnormal lung lobation (HP:0002101)2.23719724
66Tracheoesophageal fistula (HP:0002575)2.23243631
67Basal cell carcinoma (HP:0002671)2.22291896
68Syringomyelia (HP:0003396)2.21522895
69Spinal cord lesions (HP:0100561)2.21522895
70Multiple enchondromatosis (HP:0005701)2.20625105
71Thrombocytosis (HP:0001894)2.18189575
72Abnormal number of incisors (HP:0011064)2.17805622
73Oligodactyly (HP:0012165)2.17010569
74Abnormality of the labia minora (HP:0012880)2.16719099
75Rough bone trabeculation (HP:0100670)2.15385524
76Progressive muscle weakness (HP:0003323)2.15279335
77Bone marrow hypocellularity (HP:0005528)2.15212605
78Acute lymphatic leukemia (HP:0006721)2.14977298
79Abnormality of glycolysis (HP:0004366)2.14386357
80Increased IgM level (HP:0003496)2.14368803
81Rectovaginal fistula (HP:0000143)2.14278284
82Rectal fistula (HP:0100590)2.14278284
83Acute encephalopathy (HP:0006846)2.14139169
84Pulmonary fibrosis (HP:0002206)2.11568553
85Squamous cell carcinoma (HP:0002860)2.11360092
86Cortical dysplasia (HP:0002539)2.09744657
87Increased serum pyruvate (HP:0003542)2.09597992
88Aplasia/hypoplasia of the humerus (HP:0006507)2.09326763
893-Methylglutaconic aciduria (HP:0003535)2.09326035
90Clubbing of toes (HP:0100760)2.09011623
91Oligodactyly (hands) (HP:0001180)2.08776433
92Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.07346999
93Small intestinal stenosis (HP:0012848)2.07249448
94Duodenal stenosis (HP:0100867)2.07249448
95Progressive macrocephaly (HP:0004481)2.06972262
96IgM deficiency (HP:0002850)2.06243873
97Microretrognathia (HP:0000308)2.05224592
98Neoplasm of the oral cavity (HP:0100649)2.04921152
99Premature ovarian failure (HP:0008209)2.04778521
100Supernumerary spleens (HP:0009799)2.03629370
101Insomnia (HP:0100785)2.03583401
102Increased CSF lactate (HP:0002490)2.02804059
103Mitochondrial inheritance (HP:0001427)2.02679304
104Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02410196
105Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.02088759
106Lymphoma (HP:0002665)1.98078583
107Neoplasm of the pancreas (HP:0002894)1.97852675
108Impulsivity (HP:0100710)1.97765414
109Atresia of the external auditory canal (HP:0000413)1.97266370
110Neoplasm of striated muscle (HP:0009728)1.95811642
111Renal duplication (HP:0000075)1.94721420
112Male infertility (HP:0003251)1.93993920
113Trismus (HP:0000211)1.93702907
114Missing ribs (HP:0000921)1.92912235
115Renal Fanconi syndrome (HP:0001994)1.92590193
116Poor head control (HP:0002421)1.91216320
117Prostate neoplasm (HP:0100787)1.90513357
118Intestinal fistula (HP:0100819)1.89133386
119Elevated erythrocyte sedimentation rate (HP:0003565)1.88636562
120Respiratory difficulties (HP:0002880)1.87932085
121Lipid accumulation in hepatocytes (HP:0006561)1.87568179
122Autoimmune thrombocytopenia (HP:0001973)1.87288583
123Sloping forehead (HP:0000340)1.87190520
124Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87128943
125Astrocytoma (HP:0009592)1.86019663
126Abnormality of the astrocytes (HP:0100707)1.86019663
127Macrocytic anemia (HP:0001972)1.85821933
128Obstructive lung disease (HP:0006536)1.85050036
129Chronic obstructive pulmonary disease (HP:0006510)1.85050036
130Progressive external ophthalmoplegia (HP:0000590)1.84009845
131Abnormality of macrophages (HP:0004311)1.83636186
132Personality changes (HP:0000751)1.82957722
133Tongue fasciculations (HP:0001308)1.82781936
134Vaginal fistula (HP:0004320)1.82479535
135Choanal atresia (HP:0000453)1.82230262
136Acute myeloid leukemia (HP:0004808)1.81538508
137Exertional dyspnea (HP:0002875)1.81521746
138Abnormality of T cell physiology (HP:0011840)1.79957047
139Short humerus (HP:0005792)1.79862644
140Short thumb (HP:0009778)1.79146783
14111 pairs of ribs (HP:0000878)1.78903544
142Porencephaly (HP:0002132)1.78484579
143Triphalangeal thumb (HP:0001199)1.77979791
144Cafe-au-lait spot (HP:0000957)1.77583931
145Cutaneous melanoma (HP:0012056)1.75848599
146Esophageal atresia (HP:0002032)1.75648715
147Prominent nose (HP:0000448)1.75647211
148Arteriovenous malformation (HP:0100026)1.75629385
149Ectopic kidney (HP:0000086)1.74632553
150Increased serum lactate (HP:0002151)1.74027246
151High anterior hairline (HP:0009890)1.71269321
152Absent septum pellucidum (HP:0001331)1.68906534
153Partial duplication of the phalanx of hand (HP:0009999)1.67634841
154Abnormality of the septum pellucidum (HP:0007375)1.67031484
155Exercise intolerance (HP:0003546)1.65473258
156Holoprosencephaly (HP:0001360)1.64336537
157Embryonal neoplasm (HP:0002898)1.64254474
158Duplicated collecting system (HP:0000081)1.62375078
159Aplasia/Hypoplasia of the earlobes (HP:0009906)1.62197213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.42215508
2WEE13.39115189
3NEK23.25536872
4BUB13.08444405
5TTK2.34137323
6ACVR1B2.27150221
7TESK22.19054167
8ARAF2.18671788
9NME22.02380305
10PLK41.97591492
11CCNB11.92736311
12EIF2AK11.87136144
13DYRK31.85796656
14CDK71.83145040
15PLK11.82177506
16EEF2K1.78213654
17RPS6KB21.77605370
18CDK121.75531776
19STK101.68556724
20PBK1.67575774
21TLK11.65031218
22MAP3K101.64219706
23NEK11.62663108
24RPS6KA41.58861657
25PIM11.55674591
26CHEK21.55064253
27AURKB1.52916360
28CDK41.50439989
29SRPK11.48141569
30MAP3K61.47711535
31EIF2AK31.47239154
32PNCK1.45014820
33ATR1.42362864
34MAP3K81.40950343
35MAP3K131.37692656
36MAP3K111.37195197
37VRK11.34738723
38STK41.33713351
39PIM21.33160705
40STK31.29603056
41BRSK21.29167854
42MAP3K91.27867927
43MAPKAPK31.27194985
44VRK21.18757451
45FLT31.16108926
46MATK1.14883416
47PAK41.13416477
48MOS1.11118050
49IRAK31.10152777
50TYK21.09252817
51CDK61.05508948
52AURKA1.04037401
53CDK81.02107792
54STK240.93635482
55SMG10.93091354
56ERBB40.90055537
57MARK30.89756731
58KIT0.89267593
59LATS10.89084619
60TBK10.88199497
61CHEK10.88144370
62IKBKB0.87784865
63MAP4K10.86434610
64MKNK10.86235988
65SCYL20.86165217
66JAK30.82808451
67IRAK40.82533795
68PRPF4B0.79885631
69CLK10.79005056
70PKN20.78279616
71LRRK20.77319786
72BRAF0.77229884
73BLK0.76783034
74TAOK30.75232136
75ATM0.74371458
76* CDK20.73157234
77RAF10.72091636
78CDK10.71104094
79PLK30.70310603
80CSK0.69739950
81YES10.68533736
82LATS20.68472659
83DYRK20.68443940
84CSNK2A20.66414414
85STK38L0.64279144
86MAP3K50.63602012
87DYRK1B0.63100914
88NEK90.62481902
89TAF10.62278435
90STK160.62204285
91BCKDK0.61833333
92TGFBR10.61796708
93BMX0.61199896
94IRAK20.61163854
95EPHA20.59359327
96PASK0.59167727
97DAPK30.58946497
98MKNK20.58430868
99EIF2AK20.58398049
100FGR0.58391074
101PDK20.57955871
102TSSK60.57880843
103ABL20.56877957
104ICK0.56415149
105TRPM70.55629638
106CHUK0.55490273
107PAK10.54762955
108TAOK20.53871289
109BTK0.53183047
110MELK0.52555343
111MST40.52071596
112AKT20.51625626
113CSNK2A10.51078273
114KSR20.50699186
115CDK11A0.50443190
116MAPK110.50143436
117NME10.49723755
118ZAK0.48253925
119CDK90.48212032
120RPS6KA50.48127517
121LYN0.48078366
122TESK10.47956728
123RPS6KA10.46483012
124CDK30.46147788
125BRD40.44693993
126CDK150.43934759
127CSNK1E0.43694327
128BRSK10.43605048
129DMPK0.42616648
130ILK0.41883315
131ALK0.40287851
132CDK140.39894530
133CDK180.38919263
134KSR10.30967722
135MAP2K70.29638781
136EPHB20.28549176

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.45860626
2Mismatch repair_Homo sapiens_hsa034303.87763840
3Base excision repair_Homo sapiens_hsa034103.01288237
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97589964
5Ribosome_Homo sapiens_hsa030102.75020075
6Homologous recombination_Homo sapiens_hsa034402.68349266
7Spliceosome_Homo sapiens_hsa030402.64968327
8RNA transport_Homo sapiens_hsa030132.60982523
9Cell cycle_Homo sapiens_hsa041102.60889424
10Nucleotide excision repair_Homo sapiens_hsa034202.42592789
11RNA polymerase_Homo sapiens_hsa030202.40119250
12One carbon pool by folate_Homo sapiens_hsa006702.07726081
13Fanconi anemia pathway_Homo sapiens_hsa034602.05013196
14Pyrimidine metabolism_Homo sapiens_hsa002401.96190556
15RNA degradation_Homo sapiens_hsa030181.94223635
16Oxidative phosphorylation_Homo sapiens_hsa001901.93296728
17Parkinsons disease_Homo sapiens_hsa050121.92568338
18p53 signaling pathway_Homo sapiens_hsa041151.89036222
19Proteasome_Homo sapiens_hsa030501.87021889
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80178973
21Huntingtons disease_Homo sapiens_hsa050161.73655110
22Basal transcription factors_Homo sapiens_hsa030221.67929201
23Herpes simplex infection_Homo sapiens_hsa051681.57993767
24Systemic lupus erythematosus_Homo sapiens_hsa053221.55927909
25mRNA surveillance pathway_Homo sapiens_hsa030151.45627055
26Protein export_Homo sapiens_hsa030601.43043623
27Non-homologous end-joining_Homo sapiens_hsa034501.39032216
28Legionellosis_Homo sapiens_hsa051341.34132856
29Leishmaniasis_Homo sapiens_hsa051401.28041132
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27909389
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27623285
32Epstein-Barr virus infection_Homo sapiens_hsa051691.20622080
33Viral carcinogenesis_Homo sapiens_hsa052031.18172620
34Alzheimers disease_Homo sapiens_hsa050101.16096909
35Antigen processing and presentation_Homo sapiens_hsa046121.08436876
36Folate biosynthesis_Homo sapiens_hsa007901.05626208
37Measles_Homo sapiens_hsa051621.04895627
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.04404510
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02301111
40Notch signaling pathway_Homo sapiens_hsa043300.98004135
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97923040
42Sulfur relay system_Homo sapiens_hsa041220.96323497
43Apoptosis_Homo sapiens_hsa042100.92903738
44Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92171975
45Influenza A_Homo sapiens_hsa051640.91882023
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91585964
47Pentose phosphate pathway_Homo sapiens_hsa000300.88712971
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88235004
49MicroRNAs in cancer_Homo sapiens_hsa052060.88140615
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85695028
51Hepatitis B_Homo sapiens_hsa051610.83435220
52Small cell lung cancer_Homo sapiens_hsa052220.83088527
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82766230
54HTLV-I infection_Homo sapiens_hsa051660.81051032
55Purine metabolism_Homo sapiens_hsa002300.78604290
56Colorectal cancer_Homo sapiens_hsa052100.77712527
57Shigellosis_Homo sapiens_hsa051310.77326327
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76315193
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74146740
60Asthma_Homo sapiens_hsa053100.70760302
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.69675336
62Graft-versus-host disease_Homo sapiens_hsa053320.69143442
63Allograft rejection_Homo sapiens_hsa053300.69086579
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68561503
65Oocyte meiosis_Homo sapiens_hsa041140.67802598
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66484583
67Chronic myeloid leukemia_Homo sapiens_hsa052200.66463402
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66002789
69Other glycan degradation_Homo sapiens_hsa005110.64224955
70TGF-beta signaling pathway_Homo sapiens_hsa043500.63578361
71Osteoclast differentiation_Homo sapiens_hsa043800.63368760
72Carbon metabolism_Homo sapiens_hsa012000.63254614
73mTOR signaling pathway_Homo sapiens_hsa041500.63210472
74Pyruvate metabolism_Homo sapiens_hsa006200.62929665
75Primary immunodeficiency_Homo sapiens_hsa053400.62871649
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61576819
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60185776
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59651659
79TNF signaling pathway_Homo sapiens_hsa046680.58318411
80Tuberculosis_Homo sapiens_hsa051520.57923047
81Biosynthesis of amino acids_Homo sapiens_hsa012300.57919851
82Viral myocarditis_Homo sapiens_hsa054160.57376322
83B cell receptor signaling pathway_Homo sapiens_hsa046620.57145196
84Thyroid cancer_Homo sapiens_hsa052160.56339078
85Malaria_Homo sapiens_hsa051440.54416364
86Pancreatic cancer_Homo sapiens_hsa052120.54318302
87Bladder cancer_Homo sapiens_hsa052190.53596063
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53354939
89Pertussis_Homo sapiens_hsa051330.52281219
90Non-small cell lung cancer_Homo sapiens_hsa052230.51526856
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49871324
92Acute myeloid leukemia_Homo sapiens_hsa052210.49617417
93Toxoplasmosis_Homo sapiens_hsa051450.48576210
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.48038903
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.47207216
96Salmonella infection_Homo sapiens_hsa051320.46900243
97Steroid biosynthesis_Homo sapiens_hsa001000.46673050
98Selenocompound metabolism_Homo sapiens_hsa004500.45667470
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45454443
100Renal cell carcinoma_Homo sapiens_hsa052110.44435540
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.44352499
102Hematopoietic cell lineage_Homo sapiens_hsa046400.43958372
103Basal cell carcinoma_Homo sapiens_hsa052170.42662123
104Cardiac muscle contraction_Homo sapiens_hsa042600.42659822
105Hedgehog signaling pathway_Homo sapiens_hsa043400.42476152
106Hippo signaling pathway_Homo sapiens_hsa043900.42070856
107HIF-1 signaling pathway_Homo sapiens_hsa040660.42011156
108Melanoma_Homo sapiens_hsa052180.40369167
109Wnt signaling pathway_Homo sapiens_hsa043100.39936440
110Glutathione metabolism_Homo sapiens_hsa004800.38723563
111N-Glycan biosynthesis_Homo sapiens_hsa005100.37730868
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.36457833
113Alcoholism_Homo sapiens_hsa050340.35744022
114Prostate cancer_Homo sapiens_hsa052150.35720634
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35170195
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33429862
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33205105
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32410585
119Adherens junction_Homo sapiens_hsa045200.32371864
120Vitamin B6 metabolism_Homo sapiens_hsa007500.31817321
121Pathways in cancer_Homo sapiens_hsa052000.29026706
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.28648321
123Metabolic pathways_Homo sapiens_hsa011000.28090312
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27259135
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27229523
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27105908
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27045893
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.26646935
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24738460
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23611882
131Endometrial cancer_Homo sapiens_hsa052130.23396419
132VEGF signaling pathway_Homo sapiens_hsa043700.23070360
133Glioma_Homo sapiens_hsa052140.20416435
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18164286
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15926429
136Lysine degradation_Homo sapiens_hsa003100.11168725
137ErbB signaling pathway_Homo sapiens_hsa040120.10438697
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.09436604
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.09384050

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