SAP30BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.58225095
2maturation of SSU-rRNA (GO:0030490)4.32657370
3purine nucleobase biosynthetic process (GO:0009113)4.31973218
4ribosome assembly (GO:0042255)4.25553697
5nucleobase biosynthetic process (GO:0046112)4.23117744
6ribosome biogenesis (GO:0042254)4.19162843
7DNA replication checkpoint (GO:0000076)4.18699922
8proteasome assembly (GO:0043248)4.17385234
9DNA strand elongation involved in DNA replication (GO:0006271)4.14665244
10DNA deamination (GO:0045006)4.05491956
11formation of translation preinitiation complex (GO:0001731)4.03392682
12DNA replication initiation (GO:0006270)4.00925652
13DNA strand elongation (GO:0022616)3.92741916
147-methylguanosine mRNA capping (GO:0006370)3.88210669
15NIK/NF-kappaB signaling (GO:0038061)3.85555845
16spliceosomal snRNP assembly (GO:0000387)3.81660212
17RNA capping (GO:0036260)3.81120022
187-methylguanosine RNA capping (GO:0009452)3.81120022
19telomere maintenance via semi-conservative replication (GO:0032201)3.78044711
20ribonucleoprotein complex biogenesis (GO:0022613)3.73681262
21ribosomal small subunit assembly (GO:0000028)3.72028547
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.70097633
23spliceosomal complex assembly (GO:0000245)3.69275825
24metaphase plate congression (GO:0051310)3.67156932
25regulation of podosome assembly (GO:0071801)3.67058051
26protein localization to kinetochore (GO:0034501)3.66477229
27DNA replication-dependent nucleosome assembly (GO:0006335)3.66208483
28DNA replication-dependent nucleosome organization (GO:0034723)3.66208483
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.62966176
30DNA unwinding involved in DNA replication (GO:0006268)3.61668196
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.56633410
32rRNA modification (GO:0000154)3.55338351
33rRNA processing (GO:0006364)3.50060149
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49603178
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.48857509
36somatic hypermutation of immunoglobulin genes (GO:0016446)3.48857509
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.48519073
38chaperone-mediated protein transport (GO:0072321)3.48316110
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.46501180
40establishment of chromosome localization (GO:0051303)3.44801090
41transcription-coupled nucleotide-excision repair (GO:0006283)3.44421711
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.44248347
43termination of RNA polymerase III transcription (GO:0006386)3.44248347
44termination of RNA polymerase I transcription (GO:0006363)3.43062730
45CENP-A containing nucleosome assembly (GO:0034080)3.40981458
46antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.39076673
47rRNA metabolic process (GO:0016072)3.38384844
48transcription from RNA polymerase I promoter (GO:0006360)3.37586934
49ribosomal large subunit biogenesis (GO:0042273)3.36946304
50negative regulation of ligase activity (GO:0051352)3.35751741
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35751741
52IMP biosynthetic process (GO:0006188)3.35560950
53mitotic nuclear envelope disassembly (GO:0007077)3.33684174
54telomere maintenance via recombination (GO:0000722)3.32877518
55chromatin remodeling at centromere (GO:0031055)3.30690177
56transcription elongation from RNA polymerase I promoter (GO:0006362)3.27100005
57maturation of 5.8S rRNA (GO:0000460)3.25352342
58attachment of spindle microtubules to kinetochore (GO:0008608)3.23712228
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.23614300
60mitotic recombination (GO:0006312)3.23065358
61protein deneddylation (GO:0000338)3.20481020
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19177444
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.18815225
64telomere maintenance via telomere lengthening (GO:0010833)3.17166565
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17113378
66regulation of spindle organization (GO:0090224)3.16096410
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15668557
68mitotic sister chromatid segregation (GO:0000070)3.15435862
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12588768
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12588768
71signal transduction involved in cell cycle checkpoint (GO:0072395)3.11996656
72signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11888444
73signal transduction involved in DNA damage checkpoint (GO:0072422)3.11888444
74cullin deneddylation (GO:0010388)3.11538521
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11439727
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11439727
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11439727
78transcription initiation from RNA polymerase I promoter (GO:0006361)3.11348886
79ribosomal small subunit biogenesis (GO:0042274)3.10753797
80positive regulation of chemokine biosynthetic process (GO:0045080)3.10607927
81G1/S transition of mitotic cell cycle (GO:0000082)3.10487872
82cell cycle G1/S phase transition (GO:0044843)3.10487872
83DNA replication-independent nucleosome organization (GO:0034724)3.09010856
84DNA replication-independent nucleosome assembly (GO:0006336)3.09010856
85pseudouridine synthesis (GO:0001522)3.08973879
86transcription elongation from RNA polymerase II promoter (GO:0006368)3.07439334
87protein localization to chromosome, centromeric region (GO:0071459)3.07438897
88viral transcription (GO:0019083)3.07277988
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.07144402
90membrane disassembly (GO:0030397)3.06647909
91nuclear envelope disassembly (GO:0051081)3.06647909
92protein K6-linked ubiquitination (GO:0085020)3.05864900
93mRNA splicing, via spliceosome (GO:0000398)3.02430684
94RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.02430684
95pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.02387614
96IMP metabolic process (GO:0046040)3.02195746
97RNA splicing, via transesterification reactions (GO:0000375)3.02007460
98establishment of protein localization to mitochondrial membrane (GO:0090151)3.01608931
99regulation of cellular amino acid metabolic process (GO:0006521)2.99721933
100positive regulation of viral transcription (GO:0050434)2.98685245
101translational initiation (GO:0006413)2.95998629
102histone exchange (GO:0043486)2.94936258
103nucleotide-excision repair, DNA gap filling (GO:0006297)2.93420792
104viral mRNA export from host cell nucleus (GO:0046784)2.93015783
105kinetochore organization (GO:0051383)2.92620118
106energy coupled proton transport, down electrochemical gradient (GO:0015985)2.92332335
107ATP synthesis coupled proton transport (GO:0015986)2.92332335
108rRNA methylation (GO:0031167)2.91267657
109base-excision repair, AP site formation (GO:0006285)2.90977170
110positive regulation of chromosome segregation (GO:0051984)2.90054174
111cellular component biogenesis (GO:0044085)2.89950620
112regulation of vitamin D biosynthetic process (GO:0060556)2.88958222
113positive regulation of ligase activity (GO:0051351)2.87711988
114DNA-templated transcription, elongation (GO:0006354)2.87562274
115regulation of chemokine biosynthetic process (GO:0045073)2.87029970
116regulation of mitochondrial translation (GO:0070129)2.85609126
117response to peptidoglycan (GO:0032494)2.85354374
118purine nucleotide salvage (GO:0032261)2.84700318
119protein targeting to mitochondrion (GO:0006626)2.82689745
120translational termination (GO:0006415)2.80493893
121neutrophil activation involved in immune response (GO:0002283)2.80198675
122defense response to protozoan (GO:0042832)2.78235798
123negative regulation of B cell apoptotic process (GO:0002903)2.72887084
124myeloid dendritic cell differentiation (GO:0043011)2.71454037
125negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.69187343
126establishment of protein localization to mitochondrion (GO:0072655)2.67266665
127myeloid dendritic cell activation (GO:0001773)2.66802146
128response to protozoan (GO:0001562)2.66485528
129negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.65356870
130negative regulation of cell killing (GO:0031342)2.64856894
131negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.64856894
132SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64649625
133protein targeting to ER (GO:0045047)2.64136770
134negative regulation of interleukin-12 production (GO:0032695)2.64106070
135negative regulation of DNA-templated transcription, elongation (GO:0032785)2.62848471
136negative regulation of protein ubiquitination (GO:0031397)2.62838023
137positive regulation by organism of defense response of other organism involved in symbiotic interact2.61978560
138modulation by symbiont of host immune response (GO:0052553)2.61978560
139positive regulation by symbiont of host defense response (GO:0052509)2.61978560
140modulation by symbiont of host defense response (GO:0052031)2.61978560
141modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61978560
142modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61978560
143translational elongation (GO:0006414)2.61950548
144regulation of ubiquitin-protein transferase activity (GO:0051438)2.61689495
145viral life cycle (GO:0019058)2.61477557
146negative regulation of myeloid cell apoptotic process (GO:0033033)2.59658790
147cotranslational protein targeting to membrane (GO:0006613)2.58413354
148protein localization to mitochondrion (GO:0070585)2.58199154
149protein localization to endoplasmic reticulum (GO:0070972)2.56688668
150antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.55849655
151DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.55445291
152nucleotide salvage (GO:0043173)2.52950419
153leukocyte aggregation (GO:0070486)2.52018039
154negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.51864116
155positive regulation of cell cycle arrest (GO:0071158)2.51675765
156response to interferon-beta (GO:0035456)2.51631670
157regulation of ligase activity (GO:0051340)2.51497021
158establishment of protein localization to endoplasmic reticulum (GO:0072599)2.48597480
159antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.48092718
160positive regulation of isotype switching (GO:0045830)2.45747918
161GDP-mannose metabolic process (GO:0019673)2.45273385
162establishment of viral latency (GO:0019043)2.44422091
163regulation of immunoglobulin secretion (GO:0051023)2.44111187
164immunoglobulin mediated immune response (GO:0016064)2.43427428
165antigen processing and presentation of endogenous antigen (GO:0019883)2.42960838
166purine-containing compound salvage (GO:0043101)2.41755420
167translation (GO:0006412)2.41064410
168nucleoside salvage (GO:0043174)2.39986689
169nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.38591018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.24708382
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.16314473
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.64633694
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59704514
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45810456
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.38687369
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.35921249
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.32774819
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.32473297
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.31316299
11* EST1_17652178_ChIP-ChIP_JURKAT_Human3.30847015
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14467143
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.13309543
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07114060
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91251564
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88739535
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84741770
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75237820
19XRN2_22483619_ChIP-Seq_HELA_Human2.61223616
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58939774
21VDR_23849224_ChIP-Seq_CD4+_Human2.38882230
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36966148
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.33555174
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.29995662
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26101990
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20938369
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14140312
28DCP1A_22483619_ChIP-Seq_HELA_Human2.11474978
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06911611
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05008397
31GABP_19822575_ChIP-Seq_HepG2_Human2.03516368
32FOXP3_21729870_ChIP-Seq_TREG_Human1.99438036
33TTF2_22483619_ChIP-Seq_HELA_Human1.93505540
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.91390132
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.90444571
36* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88925007
37* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78980193
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76981829
39AR_21909140_ChIP-Seq_LNCAP_Human1.76872517
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73093839
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72112316
42* ELK1_19687146_ChIP-ChIP_HELA_Human1.68832214
43CIITA_25753668_ChIP-Seq_RAJI_Human1.68829044
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.67888448
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67326933
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.66085830
47* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64778140
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64022538
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63813998
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63079584
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.59815397
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58113799
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.55635436
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53882724
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53193283
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52264319
57SPI1_23547873_ChIP-Seq_NB4_Human1.51856174
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51500042
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.51356500
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44613034
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44473981
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41870263
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41207892
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.40473860
65* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40009998
66KDM5A_27292631_Chip-Seq_BREAST_Human1.39895888
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38215324
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32581709
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32196756
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28827823
71MYC_22102868_ChIP-Seq_BL_Human1.25270016
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23924605
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23605331
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22615146
75* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20901601
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20658938
77MAF_26560356_Chip-Seq_TH1_Human1.19677242
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19406770
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.19145502
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17544912
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17518442
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16221386
83UTX_26944678_Chip-Seq_JUKART_Human1.16192633
84MAF_26560356_Chip-Seq_TH2_Human1.15696392
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13933583
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12722470
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11921049
88TFEB_21752829_ChIP-Seq_HELA_Human1.11651080
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11500929
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11087899
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10768547
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09391530
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07974201
94* ELK1_22589737_ChIP-Seq_MCF10A_Human1.07690147
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05241549
96* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05122003
97MYC_18940864_ChIP-ChIP_HL60_Human1.05059009
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04375641
99VDR_24763502_ChIP-Seq_THP-1_Human1.03589545
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03309849
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03293294
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02704107
103* TET1_21451524_ChIP-Seq_MESCs_Mouse1.02226649
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01526581
105* RUNX1_22412390_ChIP-Seq_EML_Mouse1.01195001
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01167942
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01068330
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.00829079
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00740355
110* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99638155
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99413869
112SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99327412
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99039497
114EGR1_19374776_ChIP-ChIP_THP-1_Human0.97740344
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97652681
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97344654
117CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93930588
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92554573
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90773549
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90215359
121* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89870116
122* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88939360
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88816166
124GATA1_22025678_ChIP-Seq_K562_Human0.88080174
125IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85449231
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85388030
127YY1_22570637_ChIP-Seq_MALME-3M_Human0.84616786
128TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83963545
129VDR_21846776_ChIP-Seq_THP-1_Human0.82750722
130SOX2_18692474_ChIP-Seq_MESCs_Mouse0.81891607
131FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81144535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.42845333
2MP0003111_abnormal_nucleus_morphology4.36682207
3MP0010094_abnormal_chromosome_stability4.11639166
4MP0004957_abnormal_blastocyst_morpholog4.09961503
5MP0003077_abnormal_cell_cycle4.00124920
6MP0003436_decreased_susceptibility_to3.49958975
7MP0008058_abnormal_DNA_repair3.45842597
8MP0008007_abnormal_cellular_replicative3.42545467
9MP0001835_abnormal_antigen_presentation3.24613390
10MP0001853_heart_inflammation3.17406595
11MP0002148_abnormal_hypersensitivity_rea3.00608228
12MP0009785_altered_susceptibility_to2.90207435
13MP0003724_increased_susceptibility_to2.76307154
14MP0008057_abnormal_DNA_replication2.72004984
15MP0008932_abnormal_embryonic_tissue2.67019294
16MP0005000_abnormal_immune_tolerance2.62854216
17MP0003303_peritoneal_inflammation2.58185538
18MP0001730_embryonic_growth_arrest2.45445666
19MP0005058_abnormal_lysosome_morphology2.28810679
20MP0002419_abnormal_innate_immunity2.26034120
21MP0001800_abnormal_humoral_immune2.23984915
22MP0005025_abnormal_response_to2.21566939
23MP0000350_abnormal_cell_proliferation2.20584711
24MP0003123_paternal_imprinting2.19394775
25MP0002452_abnormal_antigen_presenting2.17671637
26MP0002723_abnormal_immune_serum2.15418281
27MP0009278_abnormal_bone_marrow2.06248337
28MP0001790_abnormal_immune_system2.04998393
29MP0005387_immune_system_phenotype2.04998393
30MP0006082_CNS_inflammation2.04540987
31MP0009840_abnormal_foam_cell2.01074492
32MP0009333_abnormal_splenocyte_physiolog1.97457727
33MP0003786_premature_aging1.96251603
34MP0003718_maternal_effect1.93102515
35MP0008877_abnormal_DNA_methylation1.91408922
36MP0000685_abnormal_immune_system1.90108621
37MP0002405_respiratory_system_inflammati1.88995662
38MP0005503_abnormal_tendon_morphology1.83022788
39MP0004947_skin_inflammation1.75268240
40MP0001873_stomach_inflammation1.71867035
41MP0010307_abnormal_tumor_latency1.71414861
42MP0003191_abnormal_cellular_cholesterol1.71312429
43MP0009764_decreased_sensitivity_to1.71051899
44MP0008260_abnormal_autophagy1.70766979
45MP0002396_abnormal_hematopoietic_system1.69751374
46MP0001529_abnormal_vocalization1.68823016
47MP0001533_abnormal_skeleton_physiology1.61903567
48MP0001697_abnormal_embryo_size1.59675356
49MP0002653_abnormal_ependyma_morphology1.59069861
50MP0003950_abnormal_plasma_membrane1.54823336
51MP0001845_abnormal_inflammatory_respons1.52541891
52MP0006292_abnormal_olfactory_placode1.51404616
53MP0002080_prenatal_lethality1.47968859
54MP0005397_hematopoietic_system_phenotyp1.47015631
55MP0001545_abnormal_hematopoietic_system1.47015631
56MP0000313_abnormal_cell_death1.46634975
57MP0010155_abnormal_intestine_physiology1.44735263
58MP0002085_abnormal_embryonic_tissue1.42948413
59MP0002132_abnormal_respiratory_system1.42838236
60MP0000343_altered_response_to1.40104171
61MP0005380_embryogenesis_phenotype1.40020261
62MP0001672_abnormal_embryogenesis/_devel1.40020261
63MP0005310_abnormal_salivary_gland1.37418068
64MP0000358_abnormal_cell_content/1.37146361
65MP0003763_abnormal_thymus_physiology1.34144922
66MP0004133_heterotaxia1.33602001
67MP0008469_abnormal_protein_level1.32131185
68MP0004510_myositis1.30119511
69MP0001293_anophthalmia1.29652881
70MP0003121_genomic_imprinting1.22846867
71MP0002084_abnormal_developmental_patter1.22802738
72MP0009765_abnormal_xenobiotic_induced1.22716967
73MP0003315_abnormal_perineum_morphology1.21531542
74MP0000490_abnormal_crypts_of1.20362113
75MP0002019_abnormal_tumor_incidence1.18646016
76MP0003984_embryonic_growth_retardation1.16200158
77MP0002088_abnormal_embryonic_growth/wei1.11817568
78MP0000537_abnormal_urethra_morphology1.10756898
79MP0001727_abnormal_embryo_implantation1.07632809
80MP0005384_cellular_phenotype1.07112712
81MP0002277_abnormal_respiratory_mucosa1.07057500
82MP0008789_abnormal_olfactory_epithelium1.06132616
83MP0003075_altered_response_to1.04614810
84MP0003866_abnormal_defecation1.00222593
85MP0005166_decreased_susceptibility_to0.99148327
86MP0002210_abnormal_sex_determination0.99031983
87MP0008995_early_reproductive_senescence0.98887074
88MP0003172_abnormal_lysosome_physiology0.97252354
89MP0002398_abnormal_bone_marrow0.96961552
90MP0000703_abnormal_thymus_morphology0.96305406
91MP0003941_abnormal_skin_development0.95610996
92MP0005621_abnormal_cell_physiology0.95370398
93MP0006036_abnormal_mitochondrial_physio0.95035673
94MP0002138_abnormal_hepatobiliary_system0.94748644
95MP0002751_abnormal_autonomic_nervous0.93894867
96MP0002722_abnormal_immune_system0.93449596
97MP0009672_abnormal_birth_weight0.93444721
98MP0002160_abnormal_reproductive_system0.91445916
99MP0006054_spinal_hemorrhage0.91076127
100MP0004197_abnormal_fetal_growth/weight/0.90227380
101MP0002086_abnormal_extraembryonic_tissu0.90101526
102MP0003119_abnormal_digestive_system0.89831870
103MP0002089_abnormal_postnatal_growth/wei0.88644299
104MP0001145_abnormal_male_reproductive0.88107749
105MP0005464_abnormal_platelet_physiology0.88020610
106MP0003186_abnormal_redox_activity0.87761869
107MP0009763_increased_sensitivity_to0.87205946
108MP0002254_reproductive_system_inflammat0.86189930
109MP0001929_abnormal_gametogenesis0.86043501
110MP0008873_increased_physiological_sensi0.85094771
111MP0000689_abnormal_spleen_morphology0.84749448
112MP0005499_abnormal_olfactory_system0.84232921
113MP0005394_taste/olfaction_phenotype0.84232921
114MP0000428_abnormal_craniofacial_morphol0.83931628
115MP0003011_delayed_dark_adaptation0.83306280
116MP0003656_abnormal_erythrocyte_physiolo0.81917131
117MP0003890_abnormal_embryonic-extraembry0.81619017
118MP0002429_abnormal_blood_cell0.81414973
119MP0001849_ear_inflammation0.78807735
120MP0005389_reproductive_system_phenotype0.78748864
121MP0003861_abnormal_nervous_system0.78714761
122MP0003453_abnormal_keratinocyte_physiol0.78607127
123MP0003937_abnormal_limbs/digits/tail_de0.78051038
124MP0001348_abnormal_lacrimal_gland0.77763678
125MP0001286_abnormal_eye_development0.75026040
126MP0005390_skeleton_phenotype0.74329027
127MP0002111_abnormal_tail_morphology0.73965277
128MP0004808_abnormal_hematopoietic_stem0.72347759
129MP0000858_altered_metastatic_potential0.71945795
130MP0010030_abnormal_orbit_morphology0.71600096
131MP0005023_abnormal_wound_healing0.71171853
132MP0003938_abnormal_ear_development0.70895886
133MP0002092_abnormal_eye_morphology0.70100753
134MP0010352_gastrointestinal_tract_polyps0.69840852
135MP0001216_abnormal_epidermal_layer0.69640922
136MP0000716_abnormal_immune_system0.69508662
137MP0002332_abnormal_exercise_endurance0.69270176
138MP0001905_abnormal_dopamine_level0.69193695
139MP0003806_abnormal_nucleotide_metabolis0.68963944
140MP0005075_abnormal_melanosome_morpholog0.68910820
141MP0001542_abnormal_bone_strength0.66820527
142MP0002998_abnormal_bone_remodeling0.66751497
143MP0000653_abnormal_sex_gland0.66443454
144MP0000733_abnormal_muscle_development0.66415789
145MP0003221_abnormal_cardiomyocyte_apopto0.64261354
146MP0008438_abnormal_cutaneous_collagen0.64109067
147MP0005501_abnormal_skin_physiology0.60743359
148MP0005508_abnormal_skeleton_morphology0.60098373
149MP0005391_vision/eye_phenotype0.60073774
150MP0006035_abnormal_mitochondrial_morpho0.59994297
151MP0003566_abnormal_cell_adhesion0.59920019
152MP0001119_abnormal_female_reproductive0.57876782
153MP0002114_abnormal_axial_skeleton0.57259143
154MP0005408_hypopigmentation0.56638379
155MP0005671_abnormal_response_to0.56021655
156MP0000015_abnormal_ear_pigmentation0.55659451
157MP0003448_altered_tumor_morphology0.55331076
158MP0002420_abnormal_adaptive_immunity0.54563574
159MP0001819_abnormal_immune_cell0.54293114
160MP0002233_abnormal_nose_morphology0.52316870

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)6.08340823
2Birth length less than 3rd percentile (HP:0003561)5.52684616
3Breast hypoplasia (HP:0003187)4.10147449
4CNS hypomyelination (HP:0003429)3.90682404
5Stomatitis (HP:0010280)3.89385784
6Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.78011824
7Oral leukoplakia (HP:0002745)3.70310433
8Abnormality of the labia minora (HP:0012880)3.65406494
9Recurrent bacterial skin infections (HP:0005406)3.62983919
10Patellar aplasia (HP:0006443)3.60525111
11Abnormal number of incisors (HP:0011064)3.49471684
12Aplasia/Hypoplasia of the patella (HP:0006498)3.44804259
13Rough bone trabeculation (HP:0100670)3.40721336
14Microvesicular hepatic steatosis (HP:0001414)3.37836471
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.36619127
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.36619127
17Carpal bone hypoplasia (HP:0001498)3.33018706
18Mediastinal lymphadenopathy (HP:0100721)3.32046263
19Recurrent abscess formation (HP:0002722)3.31801939
20Hepatocellular necrosis (HP:0001404)3.31432222
21Mitochondrial inheritance (HP:0001427)3.26130144
22Reticulocytopenia (HP:0001896)3.23721858
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.20555281
24Increased hepatocellular lipid droplets (HP:0006565)3.20307661
25Degeneration of anterior horn cells (HP:0002398)3.15490373
26Abnormality of the anterior horn cell (HP:0006802)3.15490373
27Abnormality of macrophages (HP:0004311)3.04851071
28Premature graying of hair (HP:0002216)2.98425485
29Aplastic anemia (HP:0001915)2.96830780
30Hypoplasia of the capital femoral epiphysis (HP:0003090)2.93934905
31Lipid accumulation in hepatocytes (HP:0006561)2.89382827
32Loss of speech (HP:0002371)2.87552269
33Chromsome breakage (HP:0040012)2.87417939
34Myositis (HP:0100614)2.87304380
35Increased CSF lactate (HP:0002490)2.85567732
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81287644
37Renal Fanconi syndrome (HP:0001994)2.78364695
38Increased intramyocellular lipid droplets (HP:0012240)2.78325335
393-Methylglutaconic aciduria (HP:0003535)2.77851333
40Elevated erythrocyte sedimentation rate (HP:0003565)2.77823772
41Hepatosplenomegaly (HP:0001433)2.76542029
42Increased IgM level (HP:0003496)2.70310295
43Acute necrotizing encephalopathy (HP:0006965)2.69721845
44Tongue fasciculations (HP:0001308)2.67882568
45Abnormal trabecular bone morphology (HP:0100671)2.66567432
46Facial cleft (HP:0002006)2.65178095
47Selective tooth agenesis (HP:0001592)2.64883516
48Absent radius (HP:0003974)2.63307795
49Hepatic necrosis (HP:0002605)2.62909633
50Respiratory difficulties (HP:0002880)2.62873562
51Recurrent viral infections (HP:0004429)2.62512395
52Impulsivity (HP:0100710)2.62119450
53Increased muscle lipid content (HP:0009058)2.60407869
54Postnatal microcephaly (HP:0005484)2.57342268
55Abnormal mitochondria in muscle tissue (HP:0008316)2.54983658
56Eczematoid dermatitis (HP:0000976)2.54844720
57Exertional dyspnea (HP:0002875)2.54304360
58Colon cancer (HP:0003003)2.49043063
59Obstructive lung disease (HP:0006536)2.48598151
60Chronic obstructive pulmonary disease (HP:0006510)2.48598151
61IgG deficiency (HP:0004315)2.48426509
62Absent forearm bone (HP:0003953)2.46931106
63Aplasia involving forearm bones (HP:0009822)2.46931106
64Abnormality of glycolipid metabolism (HP:0010969)2.45010932
65Abnormality of liposaccharide metabolism (HP:0010968)2.45010932
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.45010932
67Bone marrow hypocellularity (HP:0005528)2.44577353
68Agnosia (HP:0010524)2.44462261
69IgM deficiency (HP:0002850)2.41235016
70Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.40392693
71Type I transferrin isoform profile (HP:0003642)2.39168943
72Orchitis (HP:0100796)2.39143306
73Ileus (HP:0002595)2.38346185
74Horseshoe kidney (HP:0000085)2.37847463
75Meckel diverticulum (HP:0002245)2.37592699
76Microretrognathia (HP:0000308)2.37379873
77Increased serum ferritin (HP:0003281)2.36906194
78Aplasia/Hypoplasia of the sacrum (HP:0008517)2.36079374
79Abnormality of the alveolar ridges (HP:0006477)2.35492433
80Absent epiphyses (HP:0010577)2.35299841
81Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.35299841
82Trismus (HP:0000211)2.33513349
83Abnormality of the preputium (HP:0100587)2.33412664
84Abnormality of cells of the erythroid lineage (HP:0012130)2.31753615
85Progressive external ophthalmoplegia (HP:0000590)2.30708716
86Increased serum lactate (HP:0002151)2.30167192
87Delusions (HP:0000746)2.28909588
88Acute encephalopathy (HP:0006846)2.28374529
89Optic neuritis (HP:0100653)2.27411506
90Retrobulbar optic neuritis (HP:0100654)2.27411506
91Hypoplastic pelvis (HP:0008839)2.25324533
92Abnormality of the umbilical cord (HP:0010881)2.25036456
93Personality changes (HP:0000751)2.24991318
94Abnormality of the ileum (HP:0001549)2.24863888
95Abnormality of the fetal cardiovascular system (HP:0010948)2.24040603
96Abnormal umbilical cord blood vessels (HP:0011403)2.24040603
97Single umbilical artery (HP:0001195)2.24040603
98Natal tooth (HP:0000695)2.22180618
99Atrophy/Degeneration involving motor neurons (HP:0007373)2.19307540
100Pancytopenia (HP:0001876)2.19216084
101Muscle fibrillation (HP:0010546)2.19198828
102Thrombocytosis (HP:0001894)2.18790188
103Abnormal number of erythroid precursors (HP:0012131)2.17491242
104Vacuolated lymphocytes (HP:0001922)2.17407150
105Mild short stature (HP:0003502)2.16976675
106Recurrent fungal infections (HP:0002841)2.16655646
107Systemic lupus erythematosus (HP:0002725)2.14681570
108Progressive macrocephaly (HP:0004481)2.12790841
109Premature ovarian failure (HP:0008209)2.12508868
110Unsteady gait (HP:0002317)2.12268067
111Secondary amenorrhea (HP:0000869)2.11744903
112Abnormality of chromosome stability (HP:0003220)2.11677963
113Premature loss of primary teeth (HP:0006323)2.11117196
114Lactic acidosis (HP:0003128)2.10663349
115Pallor (HP:0000980)2.08400847
116Poor head control (HP:0002421)2.08367230
117Increased serum pyruvate (HP:0003542)2.07221189
118Abnormality of glycolysis (HP:0004366)2.07221189
119Glossoptosis (HP:0000162)2.06137071
120Ragged-red muscle fibers (HP:0003200)2.03817359
121Small intestinal stenosis (HP:0012848)2.03392491
122Duodenal stenosis (HP:0100867)2.03392491
123Lymphoma (HP:0002665)2.02543967
124Abnormality of alanine metabolism (HP:0010916)2.02175556
125Hyperalaninemia (HP:0003348)2.02175556
126Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02175556
127Sloping forehead (HP:0000340)2.01151616
128Abnormality of renal resorption (HP:0011038)2.00244922
129Panhypogammaglobulinemia (HP:0003139)2.00170324
130Exercise intolerance (HP:0003546)1.97524479
131Parakeratosis (HP:0001036)1.97332852
132Recurrent skin infections (HP:0001581)1.97024670
133Aplasia/Hypoplasia of the uvula (HP:0010293)1.96569823
134Abnormal lung lobation (HP:0002101)1.96492037
135Respiratory failure (HP:0002878)1.95836461
136Congenital, generalized hypertrichosis (HP:0004540)1.95420342
137Ependymoma (HP:0002888)1.95279284
138Macrocytic anemia (HP:0001972)1.93354919
139Neoplasm of the pancreas (HP:0002894)1.92988419
140Recurrent gram-negative bacterial infections (HP:0005420)1.92164518
141Autoimmune thrombocytopenia (HP:0001973)1.90200983
142Neutropenia (HP:0001875)1.89719006
143Interstitial pulmonary disease (HP:0006530)1.89652517
144Optic nerve coloboma (HP:0000588)1.89445506
145Duplicated collecting system (HP:0000081)1.88049210
146Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87481125
147Abnormal protein N-linked glycosylation (HP:0012347)1.87481125
148Abnormal protein glycosylation (HP:0012346)1.87481125
149Abnormal glycosylation (HP:0012345)1.87481125
150Increased cerebral lipofuscin (HP:0011813)1.87052962
151Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86908276
152Hypertensive crisis (HP:0100735)1.86568061
153Meningitis (HP:0001287)1.86190928
154T lymphocytopenia (HP:0005403)1.85318212
155Slender long bone (HP:0003100)1.85289626
156Diaphragmatic weakness (HP:0009113)1.85234268
157Granulocytopenia (HP:0001913)1.84910165
158Cellulitis (HP:0100658)1.84866328
159Tracheoesophageal fistula (HP:0002575)1.83882478
160Triphalangeal thumb (HP:0001199)1.83784892
161Neonatal short-limb short stature (HP:0008921)1.83434513
162Multiple enchondromatosis (HP:0005701)1.82619943
163Abnormality of T cells (HP:0002843)1.82602690
164Abnormality of iron homeostasis (HP:0011031)1.81959427
165Cortical visual impairment (HP:0100704)1.81910250
166Absent thumb (HP:0009777)1.81450801
167Cellular immunodeficiency (HP:0005374)1.81419844
168Pulmonary fibrosis (HP:0002206)1.80954564
169Supernumerary spleens (HP:0009799)1.80536930
170IgA deficiency (HP:0002720)1.80191894
171Emotional lability (HP:0000712)1.79551849
172Encephalitis (HP:0002383)1.79439885
173Asplenia (HP:0001746)1.78314931
174Irregular epiphyses (HP:0010582)1.78062008
175Abnormal gallbladder physiology (HP:0012438)1.74356352
176Cholecystitis (HP:0001082)1.74356352
177B lymphocytopenia (HP:0010976)1.74329675
178Progressive muscle weakness (HP:0003323)1.74290314
179Myelodysplasia (HP:0002863)1.74039929
180Abnormalities of placenta or umbilical cord (HP:0001194)1.73654691
181Conical tooth (HP:0000698)1.73389770
182Abnormality of the clitoris (HP:0000056)1.73357220
183Abnormality of the renal collecting system (HP:0004742)1.73094794
184Ureteral duplication (HP:0000073)1.72395021
185Death in infancy (HP:0001522)1.71803380
186Medulloblastoma (HP:0002885)1.71309532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.27226037
2EIF2AK14.48576225
3WEE13.06350881
4VRK22.93392434
5TLK12.85253110
6TSSK62.76624363
7CDC72.50931950
8SRPK12.47554629
9CCNB12.30347218
10IRAK32.24965987
11TESK22.11931215
12EIF2AK32.08285121
13ACVR1B2.07624273
14STK162.01754247
15VRK11.98946228
16PDK21.95385710
17TBK11.91450369
18MKNK11.89668837
19PLK11.76842296
20PLK31.76484631
21PLK41.74900406
22TXK1.73001896
23BRSK11.69404981
24INSRR1.68017543
25SIK31.67956581
26MAP3K111.67739312
27NEK21.67708870
28BRSK21.67146037
29TTK1.62899938
30NEK11.56028193
31DYRK21.51662647
32GRK61.51424481
33MATK1.47825392
34ARAF1.47374481
35TYK21.45849375
36MAP3K141.44985862
37BCKDK1.43604745
38PRPF4B1.42646531
39BCR1.41042657
40LIMK11.36600088
41AURKA1.33678190
42KDR1.33665027
43IKBKE1.32665498
44EPHA21.31328508
45PIM21.30111670
46AURKB1.28938788
47ZAK1.28811493
48DYRK31.25973867
49ATR1.24646247
50TRIB31.24162562
51PBK1.22889987
52CDK71.22306614
53CHEK21.21994055
54MAP3K31.21085349
55NME11.20545071
56TESK11.19838807
57CDK191.18585028
58BRAF1.17670876
59PASK1.16758110
60ERN11.11400378
61MAP2K31.08336242
62MET1.07695078
63BLK1.07423640
64RPS6KA41.07231818
65TRPM71.05774241
66NME21.05488088
67GRK71.04145558
68TAOK11.03688259
69MKNK21.02123501
70MAP3K81.01870047
71CLK11.01122532
72IRAK41.00656484
73ABL21.00433076
74PAK40.96488302
75PAK10.95161623
76MST40.93338536
77CHEK10.92649493
78LRRK20.92347682
79MAP2K20.91712359
80TAOK30.91536570
81TGFBR10.89708345
82CHUK0.87468936
83EIF2AK20.87461177
84STK38L0.86893883
85SIK10.85092678
86FES0.83046353
87CSK0.81866463
88FGR0.81145260
89STK40.75768650
90RPS6KA50.75421529
91NEK60.75206948
92AKT30.74161742
93CDK80.73001687
94MARK30.72617859
95LYN0.72303815
96CDK20.70709148
97ALK0.70162626
98MELK0.69190359
99ZAP700.68317233
100TNK20.67751716
101PIM10.67470942
102STK100.66165617
103SMG10.64523046
104CDK180.62488420
105SCYL20.61751593
106CDK11A0.60067149
107CDK10.59642065
108CDK150.58156258
109DAPK30.57104805
110SIK20.56834124
111PRKCI0.56718165
112NEK90.55430541
113RPS6KB20.52796123
114MAP4K10.52500790
115CSNK1G30.52457689
116CDK140.51448615
117LATS20.50686285
118MAP3K120.50645437
119CSNK2A10.48854776
120CDK40.47976265
121ATM0.46765636
122CSNK2A20.45903225
123BTK0.45507533
124MAPKAPK20.44271825
125MAP3K130.43809739
126DAPK10.43695236
127TGFBR20.43651435
128RPS6KA10.43599690
129LCK0.42126735
130BRD40.42078812
131STK240.41806889
132JAK30.39666312
133MAP2K60.38455815
134HCK0.37813136
135MOS0.37759991
136CDK120.37028572
137BMX0.35944363
138CDC42BPA0.35748850
139ILK0.34064058
140CSF1R0.33759010
141MAP3K50.33114408
142SYK0.32995020
143RPS6KL10.31821344
144RPS6KC10.31821344
145PLK20.29292832
146OXSR10.29054699
147IKBKB0.28748926
148ROCK20.28722739
149TAOK20.26995778
150CSNK1G10.26383227

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.09577864
2Proteasome_Homo sapiens_hsa030504.09572706
3RNA polymerase_Homo sapiens_hsa030203.84195898
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.82580755
5Mismatch repair_Homo sapiens_hsa034303.42767024
6Spliceosome_Homo sapiens_hsa030403.41349033
7Base excision repair_Homo sapiens_hsa034103.22160309
8Ribosome_Homo sapiens_hsa030103.18167665
9RNA transport_Homo sapiens_hsa030132.99192509
10Nucleotide excision repair_Homo sapiens_hsa034202.67595768
11Homologous recombination_Homo sapiens_hsa034402.51432368
12Cell cycle_Homo sapiens_hsa041102.50019950
13Basal transcription factors_Homo sapiens_hsa030222.48321765
14Pyrimidine metabolism_Homo sapiens_hsa002402.38151993
15Non-homologous end-joining_Homo sapiens_hsa034502.07524316
16One carbon pool by folate_Homo sapiens_hsa006702.04554705
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91604680
18Vitamin B6 metabolism_Homo sapiens_hsa007501.84896519
19RNA degradation_Homo sapiens_hsa030181.76616768
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74102588
21Fanconi anemia pathway_Homo sapiens_hsa034601.69491879
22mRNA surveillance pathway_Homo sapiens_hsa030151.61397166
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59750436
24p53 signaling pathway_Homo sapiens_hsa041151.56945615
25Osteoclast differentiation_Homo sapiens_hsa043801.56245137
26Leishmaniasis_Homo sapiens_hsa051401.54783938
27Rheumatoid arthritis_Homo sapiens_hsa053231.49021307
28Purine metabolism_Homo sapiens_hsa002301.41748339
29Epstein-Barr virus infection_Homo sapiens_hsa051691.34757234
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33889501
31Autoimmune thyroid disease_Homo sapiens_hsa053201.33283583
32Salmonella infection_Homo sapiens_hsa051321.27132693
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26365680
34Systemic lupus erythematosus_Homo sapiens_hsa053221.24748141
35Asthma_Homo sapiens_hsa053101.23327605
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20884626
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19533073
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14369365
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11195952
40Malaria_Homo sapiens_hsa051441.10446411
41TNF signaling pathway_Homo sapiens_hsa046681.09631234
42Influenza A_Homo sapiens_hsa051641.06762427
43Viral carcinogenesis_Homo sapiens_hsa052031.06579701
44Alzheimers disease_Homo sapiens_hsa050101.05771596
45Protein export_Homo sapiens_hsa030601.02229632
46Staphylococcus aureus infection_Homo sapiens_hsa051500.95899133
47Oocyte meiosis_Homo sapiens_hsa041140.95519068
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.95324177
49Tuberculosis_Homo sapiens_hsa051520.93695526
50Acute myeloid leukemia_Homo sapiens_hsa052210.93605218
51Lysosome_Homo sapiens_hsa041420.92935338
52Pertussis_Homo sapiens_hsa051330.91000573
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90372198
54Hematopoietic cell lineage_Homo sapiens_hsa046400.88766815
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85428937
56Hepatitis C_Homo sapiens_hsa051600.84635368
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82460054
58Antigen processing and presentation_Homo sapiens_hsa046120.80439686
59Type I diabetes mellitus_Homo sapiens_hsa049400.80147356
60Toxoplasmosis_Homo sapiens_hsa051450.78528152
61B cell receptor signaling pathway_Homo sapiens_hsa046620.75696366
62Alcoholism_Homo sapiens_hsa050340.75311858
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74998408
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74004451
65Viral myocarditis_Homo sapiens_hsa054160.72878521
66Bladder cancer_Homo sapiens_hsa052190.72850634
67African trypanosomiasis_Homo sapiens_hsa051430.72217649
68Herpes simplex infection_Homo sapiens_hsa051680.72132253
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71675659
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67715440
71T cell receptor signaling pathway_Homo sapiens_hsa046600.67417287
72Apoptosis_Homo sapiens_hsa042100.64476718
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.64332114
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63598964
75Primary immunodeficiency_Homo sapiens_hsa053400.63164711
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63071419
77Fatty acid elongation_Homo sapiens_hsa000620.61818495
78Pentose phosphate pathway_Homo sapiens_hsa000300.61359062
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.60769451
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59516843
81Huntingtons disease_Homo sapiens_hsa050160.58517150
82Steroid biosynthesis_Homo sapiens_hsa001000.56346025
83HTLV-I infection_Homo sapiens_hsa051660.55287667
84Shigellosis_Homo sapiens_hsa051310.55247796
85Folate biosynthesis_Homo sapiens_hsa007900.54702918
86Legionellosis_Homo sapiens_hsa051340.53583738
87Hippo signaling pathway_Homo sapiens_hsa043900.52095984
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50838134
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50765113
90Ether lipid metabolism_Homo sapiens_hsa005650.49862385
91Biosynthesis of amino acids_Homo sapiens_hsa012300.49615776
92Glutathione metabolism_Homo sapiens_hsa004800.48640300
93Regulation of autophagy_Homo sapiens_hsa041400.46740631
94Other glycan degradation_Homo sapiens_hsa005110.46032360
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.44228751
96Chemokine signaling pathway_Homo sapiens_hsa040620.43662578
97Parkinsons disease_Homo sapiens_hsa050120.42460968
98Oxidative phosphorylation_Homo sapiens_hsa001900.41832497
99MicroRNAs in cancer_Homo sapiens_hsa052060.38532152
100Arachidonic acid metabolism_Homo sapiens_hsa005900.38262579
101Fructose and mannose metabolism_Homo sapiens_hsa000510.36744474
102Colorectal cancer_Homo sapiens_hsa052100.34784135
103Sphingolipid metabolism_Homo sapiens_hsa006000.32595907
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30253772
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29012097
106Notch signaling pathway_Homo sapiens_hsa043300.27700960
107Linoleic acid metabolism_Homo sapiens_hsa005910.26969256
108Sulfur relay system_Homo sapiens_hsa041220.25825788
109HIF-1 signaling pathway_Homo sapiens_hsa040660.25542324
110Small cell lung cancer_Homo sapiens_hsa052220.25443828
111Tight junction_Homo sapiens_hsa045300.24921487
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.24129261
113Vibrio cholerae infection_Homo sapiens_hsa051100.23269569
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23096295
115Hepatitis B_Homo sapiens_hsa051610.22770540
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.22601368
117Endocytosis_Homo sapiens_hsa041440.21678169
118Allograft rejection_Homo sapiens_hsa053300.21607485
119Measles_Homo sapiens_hsa051620.21543947
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.21026572
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20577210
122TGF-beta signaling pathway_Homo sapiens_hsa043500.20279604
123Renin-angiotensin system_Homo sapiens_hsa046140.19517536
124Phagosome_Homo sapiens_hsa041450.19246709
125Hedgehog signaling pathway_Homo sapiens_hsa043400.18555626
126Pathways in cancer_Homo sapiens_hsa052000.17649517
127Basal cell carcinoma_Homo sapiens_hsa052170.17589076
128Collecting duct acid secretion_Homo sapiens_hsa049660.17403921
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16835294
130Thyroid cancer_Homo sapiens_hsa052160.16586355
131Graft-versus-host disease_Homo sapiens_hsa053320.16534236
132Chronic myeloid leukemia_Homo sapiens_hsa052200.16316597
133Synaptic vesicle cycle_Homo sapiens_hsa047210.14340532
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13881245
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13564319
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13323096
137Galactose metabolism_Homo sapiens_hsa000520.12948424
138NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12947417

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