SAP30L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)3.73582453
2negative regulation of cell killing (GO:0031342)3.67706640
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.67706640
4translational termination (GO:0006415)3.64632684
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.63357238
6sulfur amino acid catabolic process (GO:0000098)3.59305172
7DNA deamination (GO:0045006)3.51733848
8negative regulation of fatty acid metabolic process (GO:0045922)3.47947247
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.45582425
10negative regulation of fatty acid biosynthetic process (GO:0045717)3.42466182
11serine family amino acid catabolic process (GO:0009071)3.39985920
12translational elongation (GO:0006414)3.39249216
13negative regulation of erythrocyte differentiation (GO:0045647)3.38123981
14antigen processing and presentation of endogenous antigen (GO:0019883)3.30678589
15cellular response to virus (GO:0098586)3.27410946
16transcription from mitochondrial promoter (GO:0006390)3.24722207
17translational initiation (GO:0006413)3.19244655
18folic acid metabolic process (GO:0046655)3.18606736
19nucleotide salvage (GO:0043173)3.12519356
20regulation of ARF protein signal transduction (GO:0032012)3.12345986
21regulation of cholesterol homeostasis (GO:2000188)3.11546991
22glyoxylate metabolic process (GO:0046487)3.10937199
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10778551
24ribosomal small subunit assembly (GO:0000028)3.06143025
25regulation of hippo signaling (GO:0035330)3.05021761
26proline biosynthetic process (GO:0006561)3.02987622
27glycine metabolic process (GO:0006544)3.02782200
28purine nucleotide salvage (GO:0032261)3.01223523
29trophectodermal cell differentiation (GO:0001829)3.00774202
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97842727
31positive regulation of Rap GTPase activity (GO:0032854)2.96099288
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.95783574
33mitotic G1 DNA damage checkpoint (GO:0031571)2.94290957
34ribosomal small subunit biogenesis (GO:0042274)2.92759466
35protein localization to endosome (GO:0036010)2.91725253
36formation of translation preinitiation complex (GO:0001731)2.89402410
37regulation of gene silencing by RNA (GO:0060966)2.88372453
38regulation of posttranscriptional gene silencing (GO:0060147)2.88372453
39regulation of gene silencing by miRNA (GO:0060964)2.88372453
40negative regulation of sterol transport (GO:0032372)2.86865484
41negative regulation of cholesterol transport (GO:0032375)2.86865484
42macrophage activation involved in immune response (GO:0002281)2.85562578
43embryonic process involved in female pregnancy (GO:0060136)2.83005762
44detection of other organism (GO:0098543)2.82411599
45folic acid-containing compound biosynthetic process (GO:0009396)2.81159894
46homocysteine metabolic process (GO:0050667)2.79789186
47regulation of integrin activation (GO:0033623)2.77156137
48L-phenylalanine metabolic process (GO:0006558)2.76978207
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.76978207
50sodium ion export (GO:0071436)2.74460581
51maternal placenta development (GO:0001893)2.73168274
52regulation of early endosome to late endosome transport (GO:2000641)2.73167677
53cysteine metabolic process (GO:0006534)2.72950853
54flavonoid metabolic process (GO:0009812)2.72772647
55positive regulation of receptor recycling (GO:0001921)2.70793594
56detection of molecule of bacterial origin (GO:0032490)2.70438210
57positive regulation by symbiont of host defense response (GO:0052509)2.68724020
58modulation by symbiont of host defense response (GO:0052031)2.68724020
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68724020
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68724020
61positive regulation by organism of defense response of other organism involved in symbiotic interact2.68724020
62modulation by symbiont of host immune response (GO:0052553)2.68724020
63triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.68511183
64proline metabolic process (GO:0006560)2.67778567
65barbed-end actin filament capping (GO:0051016)2.65805420
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65760669
67cellular protein complex disassembly (GO:0043624)2.65307062
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.65251709
69regulation of SMAD protein import into nucleus (GO:0060390)2.65088684
70viral life cycle (GO:0019058)2.64705302
71detection of bacterium (GO:0016045)2.64229427
72signal complex assembly (GO:0007172)2.64214567
73hypotonic response (GO:0006971)2.61498633
74mitotic G1/S transition checkpoint (GO:0044819)2.59464528
75detection of external biotic stimulus (GO:0098581)2.59103941
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58429625
77intestinal cholesterol absorption (GO:0030299)2.57568224
78positive regulation of SMAD protein import into nucleus (GO:0060391)2.57290839
79stress fiber assembly (GO:0043149)2.56961477
80protein targeting to ER (GO:0045047)2.56291691
81response to laminar fluid shear stress (GO:0034616)2.53602887
82cellular potassium ion homeostasis (GO:0030007)2.53237970
83serine family amino acid metabolic process (GO:0009069)2.52698255
84kynurenine metabolic process (GO:0070189)2.52380421
85ribosome biogenesis (GO:0042254)2.51622778
86positive regulation of T cell apoptotic process (GO:0070234)2.51305776
874-hydroxyproline metabolic process (GO:0019471)2.51202086
88positive regulation of lipid storage (GO:0010884)2.50393381
89regulation of T-helper 2 cell differentiation (GO:0045628)2.49184060
90cotranslational protein targeting to membrane (GO:0006613)2.48925711
91actin filament polymerization (GO:0030041)2.48765583
92regulation of Rap GTPase activity (GO:0032317)2.48051279
93ribonucleoprotein complex biogenesis (GO:0022613)2.47786017
94G1 DNA damage checkpoint (GO:0044783)2.46886031
95regulation of fatty acid biosynthetic process (GO:0042304)2.46795717
96mitotic metaphase plate congression (GO:0007080)2.45595785
97positive regulation of gamma-delta T cell activation (GO:0046645)2.44321325
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.43898859
99macroautophagy (GO:0016236)2.42837792
100intestinal absorption (GO:0050892)2.42714132
101phospholipid efflux (GO:0033700)2.41979554
102establishment of protein localization to endoplasmic reticulum (GO:0072599)2.41059879
103positive regulation of protein homooligomerization (GO:0032464)2.39667360
104regulation of translational termination (GO:0006449)2.38381904
105regulation of histone phosphorylation (GO:0033127)2.37996839
106protein complex disassembly (GO:0043241)2.37381881
107urate metabolic process (GO:0046415)2.37088762
108positive regulation of triglyceride biosynthetic process (GO:0010867)2.37057375
109cellular response to catecholamine stimulus (GO:0071870)2.36989648
110cellular response to monoamine stimulus (GO:0071868)2.36989648
111regulation of cholesterol metabolic process (GO:0090181)2.36609965
1122-oxoglutarate metabolic process (GO:0006103)2.35827896
113lysine metabolic process (GO:0006553)2.34529619
114lysine catabolic process (GO:0006554)2.34529619
115protein localization to endoplasmic reticulum (GO:0070972)2.34459731
116cerebellar granule cell differentiation (GO:0021707)2.34004854
117maturation of SSU-rRNA (GO:0030490)2.32365018
118nucleoside salvage (GO:0043174)2.31927865
119inner cell mass cell proliferation (GO:0001833)2.31320781
120regulation of NFAT protein import into nucleus (GO:0051532)2.31241619
121leukocyte apoptotic process (GO:0071887)2.31077555
122regulation of ARF GTPase activity (GO:0032312)2.30537604
123regulation of extracellular matrix disassembly (GO:0010715)2.30506735
124interferon-gamma secretion (GO:0072643)2.29096411
125positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.28678253
126positive regulation of Cdc42 GTPase activity (GO:0043089)2.28641885
127urea metabolic process (GO:0019627)2.28178765
128urea cycle (GO:0000050)2.28178765
129mannose metabolic process (GO:0006013)2.28154586
130positive regulation of triglyceride metabolic process (GO:0090208)2.27969740
131T cell apoptotic process (GO:0070231)2.27595301
132tryptophan metabolic process (GO:0006568)2.27589200
133cortical actin cytoskeleton organization (GO:0030866)2.27202254
134ribosomal large subunit biogenesis (GO:0042273)2.27066115
135negative regulation of fatty acid transport (GO:2000192)2.26460571
136negative regulation of type 2 immune response (GO:0002829)2.26449019
137replication fork processing (GO:0031297)2.25440762
138positive regulation of cellular amide metabolic process (GO:0034250)2.25069092
139regulation of lipid kinase activity (GO:0043550)2.25045350
140mitochondrial DNA metabolic process (GO:0032042)2.24509629
141virion attachment to host cell (GO:0019062)2.23305480
142adhesion of symbiont to host cell (GO:0044650)2.23305480
143tryptophan catabolic process (GO:0006569)2.23286677
144indole-containing compound catabolic process (GO:0042436)2.23286677
145indolalkylamine catabolic process (GO:0046218)2.23286677
146protein retention in ER lumen (GO:0006621)2.22951053
147pteridine-containing compound biosynthetic process (GO:0042559)2.22470365
148cellular glucuronidation (GO:0052695)2.22121858
149regulation of type I interferon-mediated signaling pathway (GO:0060338)2.21852037
150amino-acid betaine metabolic process (GO:0006577)2.21409998
151modulation by symbiont of host cellular process (GO:0044068)2.20666564
152lipoprotein transport (GO:0042953)2.19437722
153regulation of cholesterol biosynthetic process (GO:0045540)2.19212103
154antigen processing and presentation via MHC class Ib (GO:0002475)2.19083685
155positive regulation of protein dephosphorylation (GO:0035307)2.18958042
156drug catabolic process (GO:0042737)2.18409008
157negative regulation of toll-like receptor signaling pathway (GO:0034122)2.18111476
158negative regulation of inclusion body assembly (GO:0090084)2.17688021
159planar cell polarity pathway involved in neural tube closure (GO:0090179)2.17596640
160adenosine receptor signaling pathway (GO:0001973)2.16523605
161positive regulation of lipid kinase activity (GO:0090218)2.16213485
162negative regulation of lymphocyte mediated immunity (GO:0002707)2.13854087
163detection of biotic stimulus (GO:0009595)2.13764071
164cortical cytoskeleton organization (GO:0030865)2.13370977
165angiotensin maturation (GO:0002003)2.13244650
166cellular response to epinephrine stimulus (GO:0071872)2.11558381
167negative regulation of leukocyte mediated immunity (GO:0002704)2.11222788
168cell communication by electrical coupling (GO:0010644)2.11119832
169positive regulation of myotube differentiation (GO:0010831)2.09424280
170negative regulation of Ras protein signal transduction (GO:0046580)2.08945819
171regulation of leukocyte degranulation (GO:0043300)2.07844866
172regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.07340997
173regulation of macrophage cytokine production (GO:0010935)2.06782017
174response to nerve growth factor (GO:1990089)2.06156883
175cellular response to nerve growth factor stimulus (GO:1990090)2.06156883
176cytoskeletal anchoring at plasma membrane (GO:0007016)2.05853348
177regulation of synaptic vesicle exocytosis (GO:2000300)2.05727931
178regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.05225444
179negative regulation of neurotransmitter secretion (GO:0046929)2.05003228
180positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.04475943
181negative regulation of myotube differentiation (GO:0010832)2.04077397
182activation of JUN kinase activity (GO:0007257)2.02823169
183regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.00794411
184regulation of extracellular matrix organization (GO:1903053)1.99852625
185focal adhesion assembly (GO:0048041)1.99528928
186cell-substrate adherens junction assembly (GO:0007045)1.99528928
187response to fluid shear stress (GO:0034405)1.99422428
188negative regulation of small GTPase mediated signal transduction (GO:0051058)1.97925525
189response to peptidoglycan (GO:0032494)1.97381666
190regulation of regulated secretory pathway (GO:1903305)1.97121435
191regulation of necroptotic process (GO:0060544)1.94579481
192regulation of branching involved in prostate gland morphogenesis (GO:0060687)1.94353239
193synaptic vesicle docking involved in exocytosis (GO:0016081)1.92772158
194positive thymic T cell selection (GO:0045059)1.92674914
195Rap protein signal transduction (GO:0032486)1.92455994
196negative regulation of granulocyte differentiation (GO:0030853)1.91919129
197macrophage activation (GO:0042116)1.91715995

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.03318007
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87130225
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.60032190
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.57485369
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.53161450
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.46416887
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.42075656
8ZNF263_19887448_ChIP-Seq_K562_Human2.36549481
9STAT3_1855785_ChIP-Seq_MESCs_Mouse2.24736624
10KDM2B_26808549_Chip-Seq_K562_Human2.19436830
11E2F7_22180533_ChIP-Seq_HELA_Human2.16916976
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.11888623
13MYC_22102868_ChIP-Seq_BL_Human2.10325162
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10136530
15VDR_21846776_ChIP-Seq_THP-1_Human1.94346651
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94345544
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.91888261
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.87248671
19MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86779099
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79627476
21KDM2B_26808549_Chip-Seq_JURKAT_Human1.76744861
22NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.76631363
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73627709
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73200355
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66959972
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.66198596
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66047799
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64255706
29KLF4_18555785_ChIP-Seq_MESCs_Mouse1.59202888
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58199095
31KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57436331
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57180891
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56684908
34RACK7_27058665_Chip-Seq_MCF-7_Human1.55913154
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55067119
36ATF3_27146783_Chip-Seq_COLON_Human1.54285832
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52393270
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51735752
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47957451
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.46714839
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45801239
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45765427
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45709490
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45649504
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44156938
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43776911
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42918442
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40613453
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39948445
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39719532
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.38467413
52LXR_22292898_ChIP-Seq_THP-1_Human1.38129328
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.37066220
54DROSHA_22980978_ChIP-Seq_HELA_Human1.37023225
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.36432903
56XRN2_22483619_ChIP-Seq_HELA_Human1.35772974
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35373129
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33350380
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32489053
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32186116
61DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31221752
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31056922
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31040839
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30897274
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30822122
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29647852
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29524614
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29511403
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.29313750
70TCF7_22412390_ChIP-Seq_EML_Mouse1.28377928
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27800103
72KDM2B_26808549_Chip-Seq_DND41_Human1.27214023
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24591234
74* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24529087
75CLOCK_20551151_ChIP-Seq_293T_Human1.24251500
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24034450
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24034450
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23853157
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23479779
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22389231
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22161001
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22134361
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21667343
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.21450241
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21298473
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21215622
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20976208
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20722583
89CREB1_26743006_Chip-Seq_LNCaP_Human1.20669250
90* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20480594
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18410686
92TBX20_22328084_ChIP-Seq_HEART_Mouse1.18392159
93TBX20_22080862_ChIP-Seq_HEART_Mouse1.18392159
94* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18330030
95IRF8_27001747_Chip-Seq_BMDM_Mouse1.17728013
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.17429585
97* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16778025
98SMC4_20622854_ChIP-Seq_HELA_Human1.16619911
99NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16511002
100MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16214408
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16109505
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15690302
103SOX2_18692474_ChIP-Seq_MEFs_Mouse1.15096801
104JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15046477
105BCOR_27268052_Chip-Seq_Bcells_Human1.14531076
106MAF_26560356_Chip-Seq_TH1_Human1.13729952
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13574664
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13362629
109RARB_27405468_Chip-Seq_BRAIN_Mouse1.13235295
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12517969
111DCP1A_22483619_ChIP-Seq_HELA_Human1.12192722
112SPI1_23127762_ChIP-Seq_K562_Human1.11663379
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11046704
114SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11038041
115* GABP_19822575_ChIP-Seq_HepG2_Human1.11016743
116* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09985471
117* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09852639
118FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09245411
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09211657
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08435276
121RUNX1_22412390_ChIP-Seq_EML_Mouse1.08174131
122MAF_26560356_Chip-Seq_TH2_Human1.07013990
123STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06670503
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05795856
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05790045
126SA1_27219007_Chip-Seq_ERYTHROID_Human1.05669874
127GATA1_19941827_ChIP-Seq_MEL_Mouse1.05639144
128KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04864959
129KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04864959
130KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04864959
131BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04601653
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04545457
133CTCF_21964334_Chip-Seq_Bcells_Human1.03923353
134RUNX1_27514584_Chip-Seq_MCF-7_Human1.03592019
135SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03561494
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03498253
137ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03231030
138CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02401901
139SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02352063
140EZH2_27294783_Chip-Seq_ESCs_Mouse1.02332837
141P68_20966046_ChIP-Seq_HELA_Human1.02032322
142KDM5A_27292631_Chip-Seq_BREAST_Human1.01997558
143AR_21909140_ChIP-Seq_LNCAP_Human1.01393743
144NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00941699
145MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00899873
146TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00706006
147NCOR1_26117541_ChIP-Seq_K562_Human1.00669124
148NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00326480
149STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00144867
150GABP_17652178_ChIP-ChIP_JURKAT_Human1.00086981
151UTX_26944678_Chip-Seq_JUKART_Human0.99869199
152CTCF_27219007_Chip-Seq_Bcells_Human0.99651171
153RUNX_20019798_ChIP-Seq_JUKART_Human0.99431748
154NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98977520
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98751652
156SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98412420
157CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98286441
158* BCL6_27268052_Chip-Seq_Bcells_Human0.98042448
159SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96832500
160VDR_24763502_ChIP-Seq_THP-1_Human0.96812207
161PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96266147
162POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95973614
163NANOG_21062744_ChIP-ChIP_HESCs_Human0.95902659
164RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95131969
165UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95025114
166HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94886828
167* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94672874
168SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94465307
169IRF8_22096565_ChIP-ChIP_GC-B_Human0.93964879
170SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93803259
171SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93739237
172MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92586696
173ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92342776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.00782559
2MP0005409_darkened_coat_color3.74661013
3MP0009840_abnormal_foam_cell3.46676532
4MP0005360_urolithiasis3.40215633
5MP0002139_abnormal_hepatobiliary_system3.16018791
6MP0003705_abnormal_hypodermis_morpholog2.84876248
7MP0003693_abnormal_embryo_hatching2.79279534
8MP0005085_abnormal_gallbladder_physiolo2.64060231
9MP0003646_muscle_fatigue2.62954623
10MP0003300_gastrointestinal_ulcer2.51341464
11MP0003191_abnormal_cellular_cholesterol2.49866334
12MP0003806_abnormal_nucleotide_metabolis2.47318863
13MP0003724_increased_susceptibility_to2.38102884
14MP0005365_abnormal_bile_salt2.38003889
15MP0001958_emphysema2.30657731
16MP0005083_abnormal_biliary_tract2.24487909
17MP0010352_gastrointestinal_tract_polyps2.22685605
18MP0005451_abnormal_body_composition2.22630305
19MP0004957_abnormal_blastocyst_morpholog2.19876788
20MP0003183_abnormal_peptide_metabolism2.08625925
21MP0008260_abnormal_autophagy2.08572111
22MP0003690_abnormal_glial_cell2.03696472
23MP0008438_abnormal_cutaneous_collagen1.89088922
24MP0003279_aneurysm1.87644734
25MP0008875_abnormal_xenobiotic_pharmacok1.85043931
26MP0003091_abnormal_cell_migration1.75545675
27MP0005377_hearing/vestibular/ear_phenot1.70675392
28MP0003878_abnormal_ear_physiology1.70675392
29MP0005275_abnormal_skin_tensile1.68549452
30MP0003941_abnormal_skin_development1.66737173
31MP0003879_abnormal_hair_cell1.62307693
32MP0009278_abnormal_bone_marrow1.59862519
33MP0003329_amyloid_beta_deposits1.55718285
34MP0003283_abnormal_digestive_organ1.52328175
35MP0005397_hematopoietic_system_phenotyp1.51358595
36MP0001545_abnormal_hematopoietic_system1.51358595
37MP0004185_abnormal_adipocyte_glucose1.47273604
38MP0000609_abnormal_liver_physiology1.44939932
39MP0002998_abnormal_bone_remodeling1.44146599
40MP0005167_abnormal_blood-brain_barrier1.41907371
41MP0004859_abnormal_synaptic_plasticity1.41676084
42MP0003111_abnormal_nucleus_morphology1.40250116
43MP0002971_abnormal_brown_adipose1.35393280
44MP0003718_maternal_effect1.34660184
45MP0001730_embryonic_growth_arrest1.33357740
46MP0003186_abnormal_redox_activity1.32190625
47MP0009333_abnormal_splenocyte_physiolog1.30937453
48MP0003221_abnormal_cardiomyocyte_apopto1.29705409
49MP0002822_catalepsy1.29322825
50MP0000751_myopathy1.25780389
51MP0003453_abnormal_keratinocyte_physiol1.24055562
52MP0001851_eye_inflammation1.23866847
53MP0002877_abnormal_melanocyte_morpholog1.22194241
54MP0005332_abnormal_amino_acid1.21834745
55MP0001188_hyperpigmentation1.21664461
56MP0009780_abnormal_chondrocyte_physiolo1.20763643
57MP0002896_abnormal_bone_mineralization1.19431615
58MP0010329_abnormal_lipoprotein_level1.18740729
59MP0005257_abnormal_intraocular_pressure1.18575117
60MP0005025_abnormal_response_to1.18282652
61MP0001533_abnormal_skeleton_physiology1.17752015
62MP0003077_abnormal_cell_cycle1.17645482
63MP0004019_abnormal_vitamin_homeostasis1.16614154
64MP0000920_abnormal_myelination1.16155777
65MP0001849_ear_inflammation1.15940120
66MP0002419_abnormal_innate_immunity1.15751138
67MP0000604_amyloidosis1.15498501
68MP0005375_adipose_tissue_phenotype1.15302196
69MP0000490_abnormal_crypts_of1.15054539
70MP0010307_abnormal_tumor_latency1.11205524
71MP0005166_decreased_susceptibility_to1.11123205
72MP0003252_abnormal_bile_duct1.11046224
73MP0001666_abnormal_nutrient_absorption1.10918308
74MP0005076_abnormal_cell_differentiation1.10775528
75MP0005380_embryogenesis_phenotype1.09345481
76MP0001672_abnormal_embryogenesis/_devel1.09345481
77MP0002796_impaired_skin_barrier1.09119863
78MP0004510_myositis1.08710374
79MP0003763_abnormal_thymus_physiology1.07914960
80MP0002086_abnormal_extraembryonic_tissu1.07267182
81MP0002653_abnormal_ependyma_morphology1.05811036
82MP0005503_abnormal_tendon_morphology1.04995014
83MP0003303_peritoneal_inflammation1.04032009
84MP0003984_embryonic_growth_retardation1.03838933
85MP0005319_abnormal_enzyme/_coenzyme1.03073061
86MP0010234_abnormal_vibrissa_follicle1.02631014
87MP0004883_abnormal_blood_vessel1.01974423
88MP0006082_CNS_inflammation1.01729315
89MP0000462_abnormal_digestive_system1.01717244
90MP0002088_abnormal_embryonic_growth/wei1.01351332
91MP0005666_abnormal_adipose_tissue1.01028682
92MP0000678_abnormal_parathyroid_gland0.99297459
93MP0003866_abnormal_defecation0.98583772
94MP0000598_abnormal_liver_morphology0.98370882
95MP0004947_skin_inflammation0.97285948
96MP0001790_abnormal_immune_system0.96641280
97MP0005387_immune_system_phenotype0.96641280
98MP0001697_abnormal_embryo_size0.96110923
99MP0003123_paternal_imprinting0.95820949
100MP0008874_decreased_physiological_sensi0.95678700
101MP0000747_muscle_weakness0.94930541
102MP0000750_abnormal_muscle_regeneration0.94570029
103MP0002269_muscular_atrophy0.93464108
104MP0000685_abnormal_immune_system0.93392913
105MP0005388_respiratory_system_phenotype0.92481110
106MP0002133_abnormal_respiratory_system0.92481110
107MP0000538_abnormal_urinary_bladder0.92235191
108MP0005381_digestive/alimentary_phenotyp0.92229297
109MP0003634_abnormal_glial_cell0.91173744
110MP0009643_abnormal_urine_homeostasis0.90129257
111MP0000759_abnormal_skeletal_muscle0.89073751
112MP0008569_lethality_at_weaning0.87747714
113MP0000858_altered_metastatic_potential0.87696298
114MP0002118_abnormal_lipid_homeostasis0.87253939
115MP0003566_abnormal_cell_adhesion0.86822350
116MP0006138_congestive_heart_failure0.86698251
117MP0003315_abnormal_perineum_morphology0.86004660
118MP0001663_abnormal_digestive_system0.85846914
119MP0008004_abnormal_stomach_pH0.85845503
120MP0006036_abnormal_mitochondrial_physio0.84987331
121MP0005164_abnormal_response_to0.84866304
122MP0003436_decreased_susceptibility_to0.83897417
123MP0009115_abnormal_fat_cell0.82696028
124MP0005501_abnormal_skin_physiology0.82552547
125MP0003075_altered_response_to0.82551232
126MP0003828_pulmonary_edema0.82376330
127MP0002019_abnormal_tumor_incidence0.82052466
128MP0004858_abnormal_nervous_system0.81773125
129MP0000350_abnormal_cell_proliferation0.81382746
130MP0002080_prenatal_lethality0.80940264
131MP0002085_abnormal_embryonic_tissue0.80823980
132MP0000733_abnormal_muscle_development0.80762942
133MP0002138_abnormal_hepatobiliary_system0.80576811
134MP0004197_abnormal_fetal_growth/weight/0.80561085
135MP0003567_abnormal_fetal_cardiomyocyte0.79422575
136MP0010630_abnormal_cardiac_muscle0.78785294
137MP0005023_abnormal_wound_healing0.78329133
138MP0005390_skeleton_phenotype0.78061504
139MP0002006_tumorigenesis0.76633135
140MP0001835_abnormal_antigen_presentation0.76578340
141MP0004087_abnormal_muscle_fiber0.76524071
142MP0010155_abnormal_intestine_physiology0.76216538
143MP0002084_abnormal_developmental_patter0.75979333
144MP0005330_cardiomyopathy0.75279539
145MP0009785_altered_susceptibility_to0.75252195
146MP0005058_abnormal_lysosome_morphology0.74655031
147MP0008932_abnormal_embryonic_tissue0.74297701
148MP0002277_abnormal_respiratory_mucosa0.73851659
149MP0004270_analgesia0.73761672
150MP0004808_abnormal_hematopoietic_stem0.73605893
151MP0005464_abnormal_platelet_physiology0.73486448
152MP0003656_abnormal_erythrocyte_physiolo0.72832387
153MP0010094_abnormal_chromosome_stability0.72515700
154MP0000343_altered_response_to0.71535577
155MP0000767_abnormal_smooth_muscle0.70867990
156MP0001800_abnormal_humoral_immune0.70110256
157MP0000477_abnormal_intestine_morphology0.69961393
158MP0000534_abnormal_ureter_morphology0.69602196
159MP0000013_abnormal_adipose_tissue0.69224259
160MP0002166_altered_tumor_susceptibility0.69054003
161MP0005408_hypopigmentation0.68738795
162MP0005535_abnormal_body_temperature0.68723520
163MP0000313_abnormal_cell_death0.68198835
164MP0005623_abnormal_meninges_morphology0.68127630
165MP0002249_abnormal_larynx_morphology0.66760918
166MP0004130_abnormal_muscle_cell0.66305845
167MP0003172_abnormal_lysosome_physiology0.65452931

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)4.53684837
2Multiple enchondromatosis (HP:0005701)3.87944156
3Obstructive sleep apnea (HP:0002870)3.46911086
4Hyperglycinemia (HP:0002154)3.18053813
5Hyperglycinuria (HP:0003108)3.16090448
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.04530701
7Abnormal cartilage morphology (HP:0002763)3.03107662
8Abnormality of monocarboxylic acid metabolism (HP:0010996)2.86850475
9Xanthomatosis (HP:0000991)2.85428038
10Thin bony cortex (HP:0002753)2.80050930
11Protrusio acetabuli (HP:0003179)2.79349463
12Progressive muscle weakness (HP:0003323)2.76625197
13Increased variability in muscle fiber diameter (HP:0003557)2.75273153
14Deep venous thrombosis (HP:0002625)2.72461514
15Type 1 muscle fiber predominance (HP:0003803)2.65411068
16Gout (HP:0001997)2.64823549
17Abnormality of glycine metabolism (HP:0010895)2.63378264
18Abnormality of serine family amino acid metabolism (HP:0010894)2.63378264
19Abnormality of the 1st metacarpal (HP:0010009)2.61703680
20Hyperammonemia (HP:0001987)2.61002608
21Tetraparesis (HP:0002273)2.60775302
22Aortic aneurysm (HP:0004942)2.59132179
23Recurrent gram-negative bacterial infections (HP:0005420)2.58781916
24Difficulty running (HP:0009046)2.55976994
25Hypobetalipoproteinemia (HP:0003563)2.54540822
26Gingivitis (HP:0000230)2.52789640
27Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51475313
28Peritonitis (HP:0002586)2.48737524
29Hypochromic anemia (HP:0001931)2.48149998
30Abnormality of skeletal muscle fiber size (HP:0012084)2.46902203
31Breech presentation (HP:0001623)2.45911630
32Intrahepatic cholestasis (HP:0001406)2.42108477
33Hyporeflexia of lower limbs (HP:0002600)2.40644004
34Myocardial infarction (HP:0001658)2.38860048
35Syringomyelia (HP:0003396)2.36092856
36Spinal cord lesions (HP:0100561)2.36092856
37Increased serum ferritin (HP:0003281)2.34822249
38Hypercortisolism (HP:0001578)2.34574928
39Recurrent abscess formation (HP:0002722)2.34099173
40Cellulitis (HP:0100658)2.33251580
41Nausea (HP:0002018)2.31114160
42Hyperparathyroidism (HP:0000843)2.26942157
43Vascular tortuosity (HP:0004948)2.25844085
44Abnormality of the Achilles tendon (HP:0005109)2.23492720
45Rhabdomyolysis (HP:0003201)2.23374297
46Abnormality of cells of the erythroid lineage (HP:0012130)2.19461519
47Spastic paraparesis (HP:0002313)2.19120338
48Abnormality of fatty-acid metabolism (HP:0004359)2.18649844
49Recurrent bacterial skin infections (HP:0005406)2.18566417
50Cupped ribs (HP:0000887)2.18016104
51Neurofibrillary tangles (HP:0002185)2.17830859
52Flat acetabular roof (HP:0003180)2.17523737
53Papilledema (HP:0001085)2.17434935
54Difficulty climbing stairs (HP:0003551)2.14515874
55Systemic lupus erythematosus (HP:0002725)2.12732495
56Abnormality of the aortic arch (HP:0012303)2.11830417
57Patellar aplasia (HP:0006443)2.11140764
58Arterial tortuosity (HP:0005116)2.10549160
59Asymmetric septal hypertrophy (HP:0001670)2.10339327
60Facial hemangioma (HP:0000329)2.10007429
61Late onset (HP:0003584)2.09328133
62Cerebral aneurysm (HP:0004944)2.08074077
63Exercise-induced myalgia (HP:0003738)2.07613915
64Pustule (HP:0200039)2.07400866
65Atrioventricular block (HP:0001678)2.07316734
66Achilles tendon contracture (HP:0001771)2.04049693
67Muscle fibrillation (HP:0010546)2.04013205
68Segmental peripheral demyelination/remyelination (HP:0003481)2.03968953
69Malnutrition (HP:0004395)2.03769423
70Broad metatarsal (HP:0001783)2.03455072
71Abnormality of the distal phalanx of the thumb (HP:0009617)2.03403119
72Abnormal hemoglobin (HP:0011902)2.03127777
73Hematochezia (HP:0002573)2.03065762
74Overlapping toe (HP:0001845)2.02995919
75Aplasia/Hypoplasia of the patella (HP:0006498)2.01384862
76Abnormality of complement system (HP:0005339)2.01363812
77Aneurysm (HP:0002617)2.00155163
78Hypolipoproteinemia (HP:0010981)2.00119466
79Mitral regurgitation (HP:0001653)1.99444489
80Spontaneous hematomas (HP:0007420)1.98104433
81Esophageal varix (HP:0002040)1.97404006
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97264717
83Dilatation of the ascending aorta (HP:0005111)1.97052836
84Supranuclear gaze palsy (HP:0000605)1.96700696
85Ketosis (HP:0001946)1.95890772
86Hand muscle atrophy (HP:0009130)1.95027008
87Adenoma sebaceum (HP:0009720)1.94187076
88Angiofibromas (HP:0010615)1.94187076
89Amyloidosis (HP:0011034)1.93047166
90Shawl scrotum (HP:0000049)1.92175882
91Cerebral inclusion bodies (HP:0100314)1.91787600
92Action tremor (HP:0002345)1.91688776
93Muscle fiber splitting (HP:0003555)1.90494703
94Petechiae (HP:0000967)1.90014606
95Emphysema (HP:0002097)1.89990798
96Abnormality of the phalanges of the hallux (HP:0010057)1.89989065
97Overgrowth (HP:0001548)1.88530124
98Ventricular tachycardia (HP:0004756)1.87345923
99Mitral valve prolapse (HP:0001634)1.86571482
100Abnormality of iron homeostasis (HP:0011031)1.86502117
101Vertebral compression fractures (HP:0002953)1.85362455
102Gastrointestinal infarctions (HP:0005244)1.85094314
103Myoglobinuria (HP:0002913)1.84507342
104Axonal loss (HP:0003447)1.82645999
105Mitral stenosis (HP:0001718)1.82480368
106Abnormality of macrophages (HP:0004311)1.82286464
107Abnormality of transition element cation homeostasis (HP:0011030)1.81554885
108Foot dorsiflexor weakness (HP:0009027)1.81523568
109Aplasia/hypoplasia of the humerus (HP:0006507)1.81463467
110Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80368369
111Dicarboxylic aciduria (HP:0003215)1.80368369
112Aortic dissection (HP:0002647)1.80169270
113Increased IgE level (HP:0003212)1.78216863
114Abnormality of sulfur amino acid metabolism (HP:0004339)1.77036107
115Tongue fasciculations (HP:0001308)1.76832386
116Hypoalphalipoproteinemia (HP:0003233)1.76740009
117Turricephaly (HP:0000262)1.76677331
118Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76501827
119Abnormal vertebral ossification (HP:0100569)1.75595216
120Rapidly progressive (HP:0003678)1.74983571
121Abnormality of purine metabolism (HP:0004352)1.74673091
122Ventricular fibrillation (HP:0001663)1.74579058
123Carpal bone hypoplasia (HP:0001498)1.74086912
124Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73836037
125Abnormality of nucleobase metabolism (HP:0010932)1.72982237
126Eczematoid dermatitis (HP:0000976)1.72784294
127Upper limb amyotrophy (HP:0009129)1.72657479
128Distal upper limb amyotrophy (HP:0007149)1.72657479
129Short phalanx of the thumb (HP:0009660)1.72178021
130Abnormal delivery (HP:0001787)1.71817258
131Ketoacidosis (HP:0001993)1.71376164
132Centrally nucleated skeletal muscle fibers (HP:0003687)1.70914111
133Abnormality of the nasal mucosa (HP:0000433)1.70428333
134Abnormality of pyrimidine metabolism (HP:0004353)1.69600530
135Hypoglycemic coma (HP:0001325)1.69321443
136Hyperextensible skin (HP:0000974)1.68811748
137Ankle clonus (HP:0011448)1.68783958
138Long toe (HP:0010511)1.68280275
139Distal lower limb muscle weakness (HP:0009053)1.68076107
140Abnormality of lateral ventricle (HP:0030047)1.67313226
141Orchitis (HP:0100796)1.67022153
142Bundle branch block (HP:0011710)1.66801243
143Shallow orbits (HP:0000586)1.66795075
144Mildly elevated creatine phosphokinase (HP:0008180)1.66644658
145Thoracolumbar scoliosis (HP:0002944)1.66128122
146Fragile skin (HP:0001030)1.66005645
147Breast hypoplasia (HP:0003187)1.65998460
148Hydroxyprolinuria (HP:0003080)1.65972536
149Abnormality of proline metabolism (HP:0010907)1.65972536
150Areflexia of lower limbs (HP:0002522)1.65763612
151Distal lower limb amyotrophy (HP:0008944)1.65660044
152Fat malabsorption (HP:0002630)1.65452928
153Abnormality of the fingertips (HP:0001211)1.64719480
154Abnormal number of erythroid precursors (HP:0012131)1.64093921
155Growth hormone excess (HP:0000845)1.63301120
156Exercise-induced muscle cramps (HP:0003710)1.63146690
157Abnormality of the foot musculature (HP:0001436)1.63006108
158Autoimmune thrombocytopenia (HP:0001973)1.62819423
159Complement deficiency (HP:0004431)1.62732433
160Male infertility (HP:0003251)1.62687470
161Bone pain (HP:0002653)1.62300616
162Increased connective tissue (HP:0009025)1.62068622
163Chondrocalcinosis (HP:0000934)1.62016796
164Enlarged penis (HP:0000040)1.61936438
165Neoplasm of head and neck (HP:0012288)1.61641501
166Esophageal neoplasm (HP:0100751)1.61641501
167Atelectasis (HP:0100750)1.61566075
168Genu recurvatum (HP:0002816)1.60885932
169Abnormality of serum amino acid levels (HP:0003112)1.60360126
170Metaphyseal cupping (HP:0003021)1.60293727
171Conjunctival hamartoma (HP:0100780)1.59471364
172Short humerus (HP:0005792)1.59303866
173Myositis (HP:0100614)1.58744110
174Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.58710060
175Deep palmar crease (HP:0006191)1.58529695
176Nasal polyposis (HP:0100582)1.57827077
177Osteolytic defects of the phalanges of the hand (HP:0009771)1.57524218
178Osteolytic defects of the hand bones (HP:0009699)1.57524218
179Germ cell neoplasia (HP:0100728)1.56113500
180Gastrointestinal stroma tumor (HP:0100723)1.56072018
181Hypophosphatemia (HP:0002148)1.55041446
182Short nail (HP:0001799)1.54699117
183Spinal cord compression (HP:0002176)1.54383786
184Partial duplication of thumb phalanx (HP:0009944)1.54300681
185Slender build (HP:0001533)1.53428788
186Hyperphosphatemia (HP:0002905)1.50865300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.21215486
2TRIB33.52053897
3PRPF4B3.40860782
4LATS23.36232679
5PKN22.73228970
6RIPK12.66198763
7MAP3K112.60403074
8MAP3K102.49631518
9ARAF2.31897732
10ERN12.17516146
11NEK22.09568667
12RIPK42.09334845
13PIM22.06113237
14TBK12.03863782
15MAP3K61.97884223
16BCKDK1.90114696
17TAOK11.73246513
18STK38L1.72242549
19ABL21.65122561
20PINK11.64273610
21SIK11.57650725
22MAP2K21.56359843
23MST1R1.55049762
24SGK31.53037787
25MAP3K21.52407554
26BRAF1.52204708
27SMG11.51170242
28LRRK21.50240477
29KSR21.48381856
30BMX1.45580148
31MARK21.41952701
32EEF2K1.39465060
33DYRK1B1.37944438
34IRAK41.37617310
35PDGFRA1.35932249
36MAP4K11.33546964
37SGK21.33520102
38ACVR1B1.33100779
39PIM11.32349853
40NTRK31.29719185
41SGK2231.25594312
42SGK4941.25594312
43CAMKK11.24542545
44PRKD21.22449321
45AKT31.20075202
46ICK1.20070276
47JAK31.19362974
48MAP3K11.17217423
49GRK61.15278841
50MAPK121.13964887
51MAPK111.12628255
52NEK11.12534421
53RAF11.10217674
54CDC42BPA1.07630706
55EPHB11.06416286
56MATK1.05517250
57TYK21.03821295
58MAP3K81.03515885
59MARK31.03218113
60EPHB21.02531043
61CDK70.99964824
62MAP2K30.99929712
63STK240.96904332
64HIPK20.96723459
65JAK10.96424337
66TTN0.96329616
67STK380.93106238
68BLK0.92384670
69SCYL20.90003332
70MAP3K130.89823091
71EPHA20.89688461
72NEK90.89106397
73DMPK0.88878276
74MAPK70.87806097
75MAP3K50.87736569
76FES0.85677011
77PLK40.85195442
78BRSK20.84598537
79CDK40.84446705
80RET0.84377816
81PRKCH0.83144836
82TYRO30.82357152
83PDGFRB0.81340967
84FGFR40.81165765
85IKBKB0.80617864
86MOS0.80583635
87MAP3K140.80230626
88PLK10.80014089
89UHMK10.79662577
90STK30.79637443
91RPS6KA10.79056599
92RPS6KA40.78945700
93DDR20.78735580
94DYRK20.78500300
95TGFBR10.77095248
96RPS6KA20.77031050
97PDK10.76340160
98PTK60.76190844
99ILK0.75144959
100IKBKE0.74319813
101PTK20.71864861
102STK110.71812017
103MAP3K90.71774514
104NTRK10.70244003
105STK100.70201895
106LATS10.69629461
107ALK0.69609010
108FGFR30.68761690
109PIK3CA0.68318440
110MAP3K70.68039285
111IRAK20.66581623
112IRAK30.64421860
113TAOK20.64295080
114CSK0.64288945
115ERBB40.64116362
116NTRK20.63818582
117ZAP700.63520438
118SIK20.62176166
119WEE10.61290644
120MAP2K40.61258496
121BUB10.61192862
122CDK80.61153533
123CHUK0.61081610
124PHKG20.60321207
125PHKG10.60321207
126KSR10.59396819
127CASK0.59196915
128DYRK30.58925841
129TGFBR20.58414750
130JAK20.57579921
131CDK190.57554587
132AURKB0.57362400
133OBSCN0.57308892
134HCK0.56068786
135CAMK40.55934671
136RPS6KB20.55872110
137CDK60.55712172
138CDK120.55348631
139CHEK20.55149771
140SGK10.55073049
141BRSK10.54073155
142PDPK10.52668911
143MAP3K30.52557278
144IRAK10.51931493
145YES10.50978094
146RPS6KC10.50857089
147RPS6KL10.50857089
148PRKCZ0.49026889
149PRKG20.47103841
150PRKD10.47056231
151PRKD30.46413375
152CAMK10.46093544
153PAK10.45559749
154RPS6KA60.45447675
155NLK0.43384634
156MTOR0.43345058
157PRKCI0.42889005
158PRKAA10.41283740

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.59009620
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.76785728
3Ribosome_Homo sapiens_hsa030102.64739310
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.54772240
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26919963
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.17026918
7Folate biosynthesis_Homo sapiens_hsa007902.05522138
8Arginine biosynthesis_Homo sapiens_hsa002202.04910408
9Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99437681
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69957395
11RNA polymerase_Homo sapiens_hsa030201.67919564
12Osteoclast differentiation_Homo sapiens_hsa043801.65651054
13B cell receptor signaling pathway_Homo sapiens_hsa046621.59524931
14Long-term potentiation_Homo sapiens_hsa047201.58506724
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.55843523
16Fat digestion and absorption_Homo sapiens_hsa049751.52862475
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.51083003
18Vitamin B6 metabolism_Homo sapiens_hsa007501.50485754
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48335375
20Fatty acid degradation_Homo sapiens_hsa000711.47579769
21Renal cell carcinoma_Homo sapiens_hsa052111.45590333
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45301033
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43487003
24Biosynthesis of amino acids_Homo sapiens_hsa012301.43233444
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.43122014
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.41953793
27VEGF signaling pathway_Homo sapiens_hsa043701.38397252
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38088681
29Tryptophan metabolism_Homo sapiens_hsa003801.34481027
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33351672
31Endometrial cancer_Homo sapiens_hsa052131.31133498
32GnRH signaling pathway_Homo sapiens_hsa049121.30114951
33Nitrogen metabolism_Homo sapiens_hsa009101.29891090
34Arginine and proline metabolism_Homo sapiens_hsa003301.28178818
35Thyroid cancer_Homo sapiens_hsa052161.26947093
36Phospholipase D signaling pathway_Homo sapiens_hsa040721.24419423
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22761119
38Galactose metabolism_Homo sapiens_hsa000521.22213951
39RNA transport_Homo sapiens_hsa030131.19935316
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.19705754
41Base excision repair_Homo sapiens_hsa034101.19592718
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.19450484
43DNA replication_Homo sapiens_hsa030301.18880571
44Carbon metabolism_Homo sapiens_hsa012001.17255066
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15760870
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14064007
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13658396
48Glioma_Homo sapiens_hsa052141.13307445
49Hepatitis C_Homo sapiens_hsa051601.13287421
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12984706
51Amoebiasis_Homo sapiens_hsa051461.12541516
52PPAR signaling pathway_Homo sapiens_hsa033201.12007245
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11410219
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10038621
55Starch and sucrose metabolism_Homo sapiens_hsa005001.09557129
56One carbon pool by folate_Homo sapiens_hsa006701.08865742
57Selenocompound metabolism_Homo sapiens_hsa004501.07430713
58Chemokine signaling pathway_Homo sapiens_hsa040621.07339196
59Pentose phosphate pathway_Homo sapiens_hsa000301.06551987
60Dorso-ventral axis formation_Homo sapiens_hsa043201.05156890
61Estrogen signaling pathway_Homo sapiens_hsa049151.04656771
62mTOR signaling pathway_Homo sapiens_hsa041501.03700138
63ErbB signaling pathway_Homo sapiens_hsa040121.03669817
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03477720
65p53 signaling pathway_Homo sapiens_hsa041151.03437477
66Sulfur metabolism_Homo sapiens_hsa009201.00936093
67Choline metabolism in cancer_Homo sapiens_hsa052311.00449261
68Tuberculosis_Homo sapiens_hsa051520.99364933
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98292419
70Chemical carcinogenesis_Homo sapiens_hsa052040.97727910
71Fructose and mannose metabolism_Homo sapiens_hsa000510.97511104
72Acute myeloid leukemia_Homo sapiens_hsa052210.97115421
73Inositol phosphate metabolism_Homo sapiens_hsa005620.97103485
74Complement and coagulation cascades_Homo sapiens_hsa046100.95151536
75Proteasome_Homo sapiens_hsa030500.93479466
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92828001
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92007946
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92007632
79Pyrimidine metabolism_Homo sapiens_hsa002400.91543882
80Endocytosis_Homo sapiens_hsa041440.90062768
81Toxoplasmosis_Homo sapiens_hsa051450.89481505
82Focal adhesion_Homo sapiens_hsa045100.88012119
83Rap1 signaling pathway_Homo sapiens_hsa040150.87117115
84Bladder cancer_Homo sapiens_hsa052190.86571939
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86398315
86Peroxisome_Homo sapiens_hsa041460.84877097
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84049084
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.83327896
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82729979
90beta-Alanine metabolism_Homo sapiens_hsa004100.82447672
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81091637
92Cell cycle_Homo sapiens_hsa041100.80990613
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80977532
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80345125
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79952425
96Cholinergic synapse_Homo sapiens_hsa047250.79365889
97Chronic myeloid leukemia_Homo sapiens_hsa052200.78987545
98MAPK signaling pathway_Homo sapiens_hsa040100.78709634
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78643811
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78524451
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78460736
102Renin secretion_Homo sapiens_hsa049240.78451125
103Gastric acid secretion_Homo sapiens_hsa049710.77872451
104Gap junction_Homo sapiens_hsa045400.76988069
105Prostate cancer_Homo sapiens_hsa052150.76816800
106Protein digestion and absorption_Homo sapiens_hsa049740.76697065
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76030598
108Melanogenesis_Homo sapiens_hsa049160.75713165
109Platelet activation_Homo sapiens_hsa046110.75692915
110Adherens junction_Homo sapiens_hsa045200.74913707
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74550866
112Malaria_Homo sapiens_hsa051440.74018425
113Glutathione metabolism_Homo sapiens_hsa004800.73566529
114Fatty acid metabolism_Homo sapiens_hsa012120.73155729
115TNF signaling pathway_Homo sapiens_hsa046680.72819271
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71130246
117T cell receptor signaling pathway_Homo sapiens_hsa046600.69930395
118Colorectal cancer_Homo sapiens_hsa052100.69342008
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68693951
120Proteoglycans in cancer_Homo sapiens_hsa052050.68345160
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.68113015
122Amphetamine addiction_Homo sapiens_hsa050310.68104470
123Dilated cardiomyopathy_Homo sapiens_hsa054140.67981695
124AMPK signaling pathway_Homo sapiens_hsa041520.67941232
125Other glycan degradation_Homo sapiens_hsa005110.67852549
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67125847
127Oxytocin signaling pathway_Homo sapiens_hsa049210.64622824
128Phagosome_Homo sapiens_hsa041450.64268344
129Mismatch repair_Homo sapiens_hsa034300.63948889
130Influenza A_Homo sapiens_hsa051640.63942256
131Herpes simplex infection_Homo sapiens_hsa051680.63906944
132Caffeine metabolism_Homo sapiens_hsa002320.61902586
133Salmonella infection_Homo sapiens_hsa051320.60926973
134cAMP signaling pathway_Homo sapiens_hsa040240.60568617
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59986050
136Spliceosome_Homo sapiens_hsa030400.59979910
137Ras signaling pathway_Homo sapiens_hsa040140.59764586
138Pertussis_Homo sapiens_hsa051330.59464493
139Propanoate metabolism_Homo sapiens_hsa006400.59071430
140Butanoate metabolism_Homo sapiens_hsa006500.58896351
141Legionellosis_Homo sapiens_hsa051340.58434834
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.58332260
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57689232
144Type II diabetes mellitus_Homo sapiens_hsa049300.57102055
145Axon guidance_Homo sapiens_hsa043600.55027974
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.54972760
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.54965359
148Insulin resistance_Homo sapiens_hsa049310.54411055
149Dopaminergic synapse_Homo sapiens_hsa047280.54090216
150Staphylococcus aureus infection_Homo sapiens_hsa051500.52803462
151Apoptosis_Homo sapiens_hsa042100.52594720
152Insulin signaling pathway_Homo sapiens_hsa049100.51217202
153Bile secretion_Homo sapiens_hsa049760.50631126
154Histidine metabolism_Homo sapiens_hsa003400.50314102
155Phenylalanine metabolism_Homo sapiens_hsa003600.49480539
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49466081
157Vitamin digestion and absorption_Homo sapiens_hsa049770.48014302
158Prolactin signaling pathway_Homo sapiens_hsa049170.47231071
159Small cell lung cancer_Homo sapiens_hsa052220.46842382
160Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45493803
161Shigellosis_Homo sapiens_hsa051310.43839343
162Lysine degradation_Homo sapiens_hsa003100.43348460
163HIF-1 signaling pathway_Homo sapiens_hsa040660.41797191
164FoxO signaling pathway_Homo sapiens_hsa040680.41310695
165Retinol metabolism_Homo sapiens_hsa008300.41213839
166Notch signaling pathway_Homo sapiens_hsa043300.40667787
167Fatty acid biosynthesis_Homo sapiens_hsa000610.40656228
168Pancreatic cancer_Homo sapiens_hsa052120.40473930
169Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39517662
170Hepatitis B_Homo sapiens_hsa051610.39049075
171Pyruvate metabolism_Homo sapiens_hsa006200.37105039
172MicroRNAs in cancer_Homo sapiens_hsa052060.36877005
173Leishmaniasis_Homo sapiens_hsa051400.36613707
174TGF-beta signaling pathway_Homo sapiens_hsa043500.36202168
175Non-small cell lung cancer_Homo sapiens_hsa052230.35933902
176Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35850981
177Prion diseases_Homo sapiens_hsa050200.34140424

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »