SAPCD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)8.29524925
2peripheral nervous system neuron development (GO:0048935)8.23817282
3negative regulation of dendrite morphogenesis (GO:0050774)7.50279372
4detection of temperature stimulus involved in sensory perception (GO:0050961)6.85708677
5detection of temperature stimulus involved in sensory perception of pain (GO:0050965)6.85708677
6negative regulation of calcium ion transport into cytosol (GO:0010523)6.43691935
7regulation of protein heterodimerization activity (GO:0043497)6.33878781
8detection of temperature stimulus (GO:0016048)6.31817482
9cell migration in hindbrain (GO:0021535)6.31204036
10cotranslational protein targeting to membrane (GO:0006613)6.30959176
11protein targeting to ER (GO:0045047)6.26831729
12establishment of protein localization to endoplasmic reticulum (GO:0072599)6.00684359
13protein localization to endoplasmic reticulum (GO:0070972)5.86347618
14ribosomal small subunit biogenesis (GO:0042274)5.63162040
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.60716204
16ATP synthesis coupled proton transport (GO:0015986)5.28684827
17energy coupled proton transport, down electrochemical gradient (GO:0015985)5.28684827
18maturation of SSU-rRNA (GO:0030490)5.17071107
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.15735120
20centriole replication (GO:0007099)4.99189340
21negative regulation of homotypic cell-cell adhesion (GO:0034111)4.81166175
22kinetochore organization (GO:0051383)4.66957529
23kinetochore assembly (GO:0051382)4.60932654
24establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.60181625
25mitochondrion transport along microtubule (GO:0047497)4.60181625
26negative regulation of dendrite development (GO:2000171)4.50224524
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.48779268
28epithelial cilium movement (GO:0003351)4.30727528
29chromatin remodeling at centromere (GO:0031055)4.20956103
30establishment of mitochondrion localization (GO:0051654)4.17764981
31regulation of NFAT protein import into nucleus (GO:0051532)4.10824073
32nuclear-transcribed mRNA catabolic process (GO:0000956)4.10732029
33protein targeting to membrane (GO:0006612)4.09192096
34respiratory electron transport chain (GO:0022904)4.08832258
35calcium-mediated signaling using intracellular calcium source (GO:0035584)4.06269819
36replication fork processing (GO:0031297)4.05997067
37electron transport chain (GO:0022900)4.05058321
38regulation of translational termination (GO:0006449)4.00076854
39regulation of platelet aggregation (GO:0090330)3.97541567
40ribosomal large subunit biogenesis (GO:0042273)3.96920713
41CENP-A containing nucleosome assembly (GO:0034080)3.92473516
42mRNA catabolic process (GO:0006402)3.89874302
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.89156950
44NADH dehydrogenase complex assembly (GO:0010257)3.89156950
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.89156950
46inositol phosphate catabolic process (GO:0071545)3.86259256
47intermediate filament organization (GO:0045109)3.85549659
48innervation (GO:0060384)3.78706377
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.78265817
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77716001
51ribosomal small subunit assembly (GO:0000028)3.76486411
52centriole assembly (GO:0098534)3.74144233
53protein complex biogenesis (GO:0070271)3.67836048
54cilium movement (GO:0003341)3.67278087
55granulocyte differentiation (GO:0030851)3.67083464
56RNA catabolic process (GO:0006401)3.64716862
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.63660719
58synapsis (GO:0007129)3.63117106
59translation (GO:0006412)3.56266826
60DNA strand elongation involved in DNA replication (GO:0006271)3.53702019
61cranial nerve development (GO:0021545)3.50371088
62base-excision repair, AP site formation (GO:0006285)3.48343264
63negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.47352073
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.46510606
65telomere maintenance via semi-conservative replication (GO:0032201)3.43485530
66DNA strand renaturation (GO:0000733)3.42558384
67ATP biosynthetic process (GO:0006754)3.41620756
68protein localization to microtubule (GO:0035372)3.34337521
69neuron fate specification (GO:0048665)3.33478833
70DNA topological change (GO:0006265)3.33014647
71axonemal dynein complex assembly (GO:0070286)3.32277197
72pyrimidine nucleotide catabolic process (GO:0006244)3.32261648
73meiotic chromosome segregation (GO:0045132)3.32161519
74motile cilium assembly (GO:0044458)3.31501721
75maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.31079181
76establishment of integrated proviral latency (GO:0075713)3.30950546
77mitochondrial respiratory chain complex assembly (GO:0033108)3.29237350
78DNA strand elongation (GO:0022616)3.27637611
79GMP metabolic process (GO:0046037)3.27372697
80response to acidic pH (GO:0010447)3.25231600
81resolution of meiotic recombination intermediates (GO:0000712)3.24290922
82purine nucleoside triphosphate biosynthetic process (GO:0009145)3.23739495
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.23621357
84negative regulation of bone resorption (GO:0045779)3.20750020
85viral transcription (GO:0019083)3.18544908
86CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.17301365
87pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.16428574
88negative regulation of erythrocyte differentiation (GO:0045647)3.15764307
89axon development (GO:0061564)3.15566805
90histone exchange (GO:0043486)3.14701694
91intraciliary transport (GO:0042073)3.14389310
92purine-containing compound salvage (GO:0043101)3.13636128
93DNA unwinding involved in DNA replication (GO:0006268)3.13524055
94ventricular trabecula myocardium morphogenesis (GO:0003222)3.13395918
95embryonic hemopoiesis (GO:0035162)3.13336997
96chaperone-mediated protein transport (GO:0072321)3.13111023
97positive regulation of B cell differentiation (GO:0045579)3.11822717
98male meiosis I (GO:0007141)3.10195171
99T cell lineage commitment (GO:0002360)3.04912318
100inner mitochondrial membrane organization (GO:0007007)3.03757972
101lens fiber cell differentiation (GO:0070306)3.03719733
102translational elongation (GO:0006414)3.03057778
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01649079
104translational termination (GO:0006415)3.00142113
105megakaryocyte development (GO:0035855)2.99146401
106establishment or maintenance of monopolar cell polarity (GO:0061339)2.97916409
107establishment of monopolar cell polarity (GO:0061162)2.97916409
108ribonucleoprotein complex biogenesis (GO:0022613)2.97819170
109ribonucleoside triphosphate biosynthetic process (GO:0009201)2.97320613
110oxidative phosphorylation (GO:0006119)2.95702888
111cellular component biogenesis (GO:0044085)2.95638256
112centrosome organization (GO:0051297)2.95301367
113regulation of mitochondrial translation (GO:0070129)2.92703826
114meiosis I (GO:0007127)2.90676212
115regulation of relaxation of muscle (GO:1901077)2.90629790
116definitive hemopoiesis (GO:0060216)2.90146243
117protein neddylation (GO:0045116)2.87093795
118exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85658268
119aerobic respiration (GO:0009060)2.85535444
120DNA replication-independent nucleosome assembly (GO:0006336)2.84203958
121DNA replication-independent nucleosome organization (GO:0034724)2.84203958
122recombinational repair (GO:0000725)2.83351997
123deoxyribonucleotide catabolic process (GO:0009264)2.81362209
124cellular protein complex localization (GO:0034629)2.79913981
125positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.79501218
126hydrogen ion transmembrane transport (GO:1902600)2.78872317
127modulation by virus of host process (GO:0019054)2.78782568
128double-strand break repair via homologous recombination (GO:0000724)2.78716428
129microtubule depolymerization (GO:0007019)2.78412890
130cellular protein complex disassembly (GO:0043624)2.78238031
131negative regulation of striated muscle cell apoptotic process (GO:0010664)2.78213907
132positive regulation of protein export from nucleus (GO:0046827)2.78162468
133positive regulation of megakaryocyte differentiation (GO:0045654)2.77690607
134rRNA modification (GO:0000154)2.76944230
135neuron fate determination (GO:0048664)2.75315615
136protein complex localization (GO:0031503)2.74774462
137regulation of protein homodimerization activity (GO:0043496)2.74478989
138DNA replication initiation (GO:0006270)2.74049487
139nucleoside triphosphate biosynthetic process (GO:0009142)2.72984218
140microtubule organizing center organization (GO:0031023)2.71774957
141regulation of erythrocyte differentiation (GO:0045646)2.70725047
142deoxyribose phosphate biosynthetic process (GO:0046385)2.70488614
1432-deoxyribonucleotide biosynthetic process (GO:0009265)2.70488614
144negative regulation of platelet activation (GO:0010544)2.70310541
145mechanoreceptor differentiation (GO:0042490)2.70050384
146DNA deamination (GO:0045006)2.69754011
147viral life cycle (GO:0019058)2.69028904
148cell proliferation in forebrain (GO:0021846)2.68518698
149organelle disassembly (GO:1903008)2.68313634
150glucocorticoid receptor signaling pathway (GO:0042921)2.68228755
151Arp2/3 complex-mediated actin nucleation (GO:0034314)2.67342216
152protein targeting (GO:0006605)2.67049723
153GTP biosynthetic process (GO:0006183)2.66623259
154establishment of protein localization to membrane (GO:0090150)2.66444685
155chromosome organization involved in meiosis (GO:0070192)2.66135370
156preassembly of GPI anchor in ER membrane (GO:0016254)2.65923723
157negative regulation of bone remodeling (GO:0046851)2.65118302
158detection of mechanical stimulus involved in sensory perception (GO:0050974)2.64751880
159nucleotide-excision repair, DNA gap filling (GO:0006297)2.60394758
160heart trabecula morphogenesis (GO:0061384)2.59816126
161protein complex disassembly (GO:0043241)2.59552344
162regulation of glycogen (starch) synthase activity (GO:2000465)2.59343168
163macromolecular complex disassembly (GO:0032984)2.59030867
164neuronal action potential propagation (GO:0019227)2.58974627
165telomere maintenance via recombination (GO:0000722)2.58363479
166translational initiation (GO:0006413)2.57113660
167protein refolding (GO:0042026)2.54793175
168mitotic G1 DNA damage checkpoint (GO:0031571)2.54271223
169platelet formation (GO:0030220)2.54169070
170protein localization to kinetochore (GO:0034501)2.53776110
171ribonucleoprotein complex disassembly (GO:0032988)2.52460252
172positive regulation of cell cycle checkpoint (GO:1901978)2.51714831
173cullin deneddylation (GO:0010388)2.50414220
174nerve development (GO:0021675)2.49558466
175positive regulation of granulocyte differentiation (GO:0030854)2.47490386
176SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.47352852
177negative regulation of RNA splicing (GO:0033119)2.47178539
178DNA replication checkpoint (GO:0000076)2.47078713
179regulation of cell maturation (GO:1903429)2.46064999
180negative regulation of neurological system process (GO:0031645)2.45428965
181mitotic recombination (GO:0006312)2.44443729
182deoxyribonucleotide biosynthetic process (GO:0009263)2.43098283
183iron coordination entity transport (GO:1901678)2.42852710
184intermediate filament cytoskeleton organization (GO:0045104)2.41940507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.16415399
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.46755624
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.37388773
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.32149877
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.06671886
6MYC_22102868_ChIP-Seq_BL_Human2.94706857
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.89621463
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81847907
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.74577292
10VDR_21846776_ChIP-Seq_THP-1_Human2.70008336
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.52443447
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50458635
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45005755
14CIITA_25753668_ChIP-Seq_RAJI_Human2.40762984
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39583291
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35240644
17* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25501407
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.25426511
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.24984705
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21039089
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.21022387
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.19841042
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.19299736
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15959701
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13647399
26ZNF274_21170338_ChIP-Seq_K562_Hela2.13177954
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11214402
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10584636
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.08813785
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02896877
31XRN2_22483619_ChIP-Seq_HELA_Human1.99092702
32GATA1_22025678_ChIP-Seq_K562_Human1.94211516
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92438287
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90560972
35VDR_23849224_ChIP-Seq_CD4+_Human1.88996141
36FOXP3_21729870_ChIP-Seq_TREG_Human1.87920058
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.87290404
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86978693
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83317232
40SCL_19346495_ChIP-Seq_HPC-7_Human1.82647001
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81371997
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79974266
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75409717
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74842815
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71790367
46EZH2_22144423_ChIP-Seq_EOC_Human1.69784019
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69712072
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.68032579
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.66635675
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61856244
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61838433
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61805578
53GABP_19822575_ChIP-Seq_HepG2_Human1.60266727
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60118303
55TTF2_22483619_ChIP-Seq_HELA_Human1.55176072
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.54975374
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52392830
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52121702
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50105275
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48153224
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45578519
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.44694236
63DCP1A_22483619_ChIP-Seq_HELA_Human1.43805595
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42948495
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42898920
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.39006678
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38611598
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36715391
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36584950
70VDR_24763502_ChIP-Seq_THP-1_Human1.35267680
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33432673
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32006312
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.31187198
74EWS_26573619_Chip-Seq_HEK293_Human1.30638548
75FUS_26573619_Chip-Seq_HEK293_Human1.30637409
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.29635800
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27296413
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.27074188
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25268665
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24333077
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24117145
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24003281
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23515364
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22282785
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21557002
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20923119
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20629885
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20489872
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19653138
90IGF1R_20145208_ChIP-Seq_DFB_Human1.19170127
91KDM5A_27292631_Chip-Seq_BREAST_Human1.18525061
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18268256
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17530128
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17512832
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17468679
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17027667
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16989257
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16708285
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.16352220
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15024371
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14562414
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12044538
103MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11639477
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10797517
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10794700
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.10330102
107CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10136839
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09403395
109VDR_22108803_ChIP-Seq_LS180_Human1.06827100
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06257990
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06143145
112MYC_18940864_ChIP-ChIP_HL60_Human1.06112981
113RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06070543
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05566957
115UTX_26944678_Chip-Seq_JUKART_Human1.05564199
116CBX2_27304074_Chip-Seq_ESCs_Mouse1.05530155
117FOXP1_21924763_ChIP-Seq_HESCs_Human1.04902491
118IRF1_19129219_ChIP-ChIP_H3396_Human1.04284978
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03695106
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03201898
121TP53_22573176_ChIP-Seq_HFKS_Human1.00935291
122EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99878965
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99867161
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99098773
125ELK1_19687146_ChIP-ChIP_HELA_Human0.98997069
126ERA_21632823_ChIP-Seq_H3396_Human0.98262673
127E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97798879
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97515633
129TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96021876
130KDM2B_26808549_Chip-Seq_DND41_Human0.95113605
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93162792
132WDR5_24793694_ChIP-Seq_LNCAP_Human0.92286235
133PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90287206
134P53_21459846_ChIP-Seq_SAOS-2_Human0.90278814
135ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89709821
136NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88123884
137BCL6_27268052_Chip-Seq_Bcells_Human0.86167215
138AR_20517297_ChIP-Seq_VCAP_Human0.85661921
139POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84220807
140TAF2_19829295_ChIP-Seq_ESCs_Human0.83295037
141NANOG_20526341_ChIP-Seq_ESCs_Human0.83014732
142GATA3_21867929_ChIP-Seq_TH1_Mouse0.82493663
143ELF1_20517297_ChIP-Seq_JURKAT_Human0.82334902
144CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81309440
145SOX2_16153702_ChIP-ChIP_HESCs_Human0.80319085
146NCOR_22424771_ChIP-Seq_293T_Human0.79859636
147ETV2_25802403_ChIP-Seq_MESCs_Mouse0.79449053
148TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78135024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level6.45801203
2MP0002735_abnormal_chemical_nociception5.95529782
3MP0006292_abnormal_olfactory_placode5.15436435
4MP0001986_abnormal_taste_sensitivity4.02823298
5MP0000566_synostosis3.96601646
6MP0009379_abnormal_foot_pigmentation3.56291906
7MP0003136_yellow_coat_color3.51436628
8MP0006276_abnormal_autonomic_nervous3.25011581
9MP0004270_analgesia3.13793321
10MP0010030_abnormal_orbit_morphology2.91554072
11MP0001348_abnormal_lacrimal_gland2.63342406
12MP0001545_abnormal_hematopoietic_system2.62585640
13MP0005397_hematopoietic_system_phenotyp2.62585640
14MP0002938_white_spotting2.61521806
15MP0002396_abnormal_hematopoietic_system2.56259072
16MP0002751_abnormal_autonomic_nervous2.48394157
17MP0002653_abnormal_ependyma_morphology2.39708302
18MP0003656_abnormal_erythrocyte_physiolo2.31750470
19MP0008789_abnormal_olfactory_epithelium2.28179770
20MP0004858_abnormal_nervous_system2.22416822
21MP0003191_abnormal_cellular_cholesterol2.21111229
22MP0010094_abnormal_chromosome_stability2.17128435
23MP0000372_irregular_coat_pigmentation2.06081944
24MP0002736_abnormal_nociception_after2.03972863
25MP0009278_abnormal_bone_marrow1.95351613
26MP0002234_abnormal_pharynx_morphology1.87794871
27MP0005499_abnormal_olfactory_system1.84804084
28MP0005394_taste/olfaction_phenotype1.84804084
29MP0003693_abnormal_embryo_hatching1.81134462
30MP0008877_abnormal_DNA_methylation1.76715904
31MP0008995_early_reproductive_senescence1.74518157
32MP0004808_abnormal_hematopoietic_stem1.71292123
33MP0001919_abnormal_reproductive_system1.68396051
34MP0002734_abnormal_mechanical_nocicepti1.68168769
35MP0001293_anophthalmia1.64086478
36MP0002733_abnormal_thermal_nociception1.63834180
37MP0000631_abnormal_neuroendocrine_gland1.60037008
38MP0008932_abnormal_embryonic_tissue1.55580227
39MP0003077_abnormal_cell_cycle1.54247151
40MP0003806_abnormal_nucleotide_metabolis1.53664000
41MP0005646_abnormal_pituitary_gland1.53534087
42MP0001970_abnormal_pain_threshold1.53296621
43MP0001485_abnormal_pinna_reflex1.52238005
44MP0002638_abnormal_pupillary_reflex1.52187295
45MP0001968_abnormal_touch/_nociception1.50030432
46MP0003111_abnormal_nucleus_morphology1.50015820
47MP0002184_abnormal_innervation1.47913800
48MP0000015_abnormal_ear_pigmentation1.46798924
49MP0003938_abnormal_ear_development1.46305019
50MP0008569_lethality_at_weaning1.46119363
51MP0002210_abnormal_sex_determination1.42299665
52MP0004957_abnormal_blastocyst_morpholog1.39650807
53MP0002249_abnormal_larynx_morphology1.39305246
54MP0005084_abnormal_gallbladder_morpholo1.37757315
55MP0004742_abnormal_vestibular_system1.37550679
56MP0002398_abnormal_bone_marrow1.35891709
57MP0003121_genomic_imprinting1.35832523
58MP0006072_abnormal_retinal_apoptosis1.35754774
59MP0003283_abnormal_digestive_organ1.35199739
60MP0008775_abnormal_heart_ventricle1.34766142
61MP0003787_abnormal_imprinting1.34029136
62MP0000026_abnormal_inner_ear1.27371671
63MP0000049_abnormal_middle_ear1.26672020
64MP0005408_hypopigmentation1.26505143
65MP0001188_hyperpigmentation1.25909367
66MP0009333_abnormal_splenocyte_physiolog1.25313290
67MP0002132_abnormal_respiratory_system1.24847727
68MP0001929_abnormal_gametogenesis1.24642651
69MP0003879_abnormal_hair_cell1.19871247
70MP0000689_abnormal_spleen_morphology1.19869585
71MP0009046_muscle_twitch1.19579146
72MP0001346_abnormal_lacrimal_gland1.18664827
73MP0002697_abnormal_eye_size1.18483720
74MP0003718_maternal_effect1.16773807
75MP0005171_absent_coat_pigmentation1.16669047
76MP0009780_abnormal_chondrocyte_physiolo1.16593257
77MP0005551_abnormal_eye_electrophysiolog1.16552960
78MP0002722_abnormal_immune_system1.15376476
79MP0003943_abnormal_hepatobiliary_system1.11957177
80MP0008875_abnormal_xenobiotic_pharmacok1.11429706
81MP0005377_hearing/vestibular/ear_phenot1.11132807
82MP0003878_abnormal_ear_physiology1.11132807
83MP0005409_darkened_coat_color1.10976231
84MP0001730_embryonic_growth_arrest1.09545106
85MP0002332_abnormal_exercise_endurance1.09482395
86MP0008007_abnormal_cellular_replicative1.08097878
87MP0000778_abnormal_nervous_system1.07797412
88MP0001145_abnormal_male_reproductive1.07621410
89MP0002095_abnormal_skin_pigmentation1.07549458
90MP0002102_abnormal_ear_morphology1.06718572
91MP0000749_muscle_degeneration1.06615658
92MP0001286_abnormal_eye_development1.05574013
93MP0000955_abnormal_spinal_cord1.05453894
94MP0003698_abnormal_male_reproductive1.05201895
95MP0003705_abnormal_hypodermis_morpholog1.04433905
96MP0000653_abnormal_sex_gland1.01730116
97MP0003122_maternal_imprinting1.01614226
98MP0002067_abnormal_sensory_capabilities1.01144719
99MP0003567_abnormal_fetal_cardiomyocyte1.00731123
100MP0005248_abnormal_Harderian_gland1.00457836
101MP0000490_abnormal_crypts_of0.99568987
102MP0006036_abnormal_mitochondrial_physio0.98767500
103MP0005389_reproductive_system_phenotype0.96859122
104MP0005195_abnormal_posterior_eye0.96206609
105MP0002233_abnormal_nose_morphology0.95503990
106MP0002928_abnormal_bile_duct0.92441454
107MP0010352_gastrointestinal_tract_polyps0.91785055
108MP0000703_abnormal_thymus_morphology0.91737210
109MP0001542_abnormal_bone_strength0.91642549
110MP0005174_abnormal_tail_pigmentation0.90876989
111MP0001764_abnormal_homeostasis0.90747296
112MP0009697_abnormal_copulation0.89890394
113MP0004133_heterotaxia0.89869927
114MP0002163_abnormal_gland_morphology0.89443382
115MP0000350_abnormal_cell_proliferation0.88842875
116MP0002429_abnormal_blood_cell0.87953033
117MP0003786_premature_aging0.87870619
118MP0005075_abnormal_melanosome_morpholog0.85684766
119MP0003763_abnormal_thymus_physiology0.85114072
120MP0002272_abnormal_nervous_system0.84548035
121MP0008872_abnormal_physiological_respon0.84376759
122MP0008057_abnormal_DNA_replication0.83293947
123MP0005645_abnormal_hypothalamus_physiol0.82424512
124MP0000313_abnormal_cell_death0.82417390
125MP0000465_gastrointestinal_hemorrhage0.82330735
126MP0001849_ear_inflammation0.81905635
127MP0004885_abnormal_endolymph0.81876781
128MP0006035_abnormal_mitochondrial_morpho0.81528753
129MP0004811_abnormal_neuron_physiology0.81221560
130MP0003186_abnormal_redox_activity0.80940245
131MP0008058_abnormal_DNA_repair0.80694064
132MP0003123_paternal_imprinting0.79006377
133MP0005671_abnormal_response_to0.78629068
134MP0005253_abnormal_eye_physiology0.78299113
135MP0000716_abnormal_immune_system0.77620097
136MP0005410_abnormal_fertilization0.77513430
137MP0001800_abnormal_humoral_immune0.76969349
138MP0002837_dystrophic_cardiac_calcinosis0.75563591
139MP0002282_abnormal_trachea_morphology0.75015810
140MP0005464_abnormal_platelet_physiology0.74925229
141MP0004883_abnormal_blood_vessel0.73760888
142MP0002557_abnormal_social/conspecific_i0.73475340
143MP0004142_abnormal_muscle_tone0.72684886
144MP0002019_abnormal_tumor_incidence0.72630630
145MP0003646_muscle_fatigue0.72103952
146MP0001119_abnormal_female_reproductive0.71824829
147MP0002160_abnormal_reproductive_system0.71441237
148MP0003866_abnormal_defecation0.71028308
149MP0003300_gastrointestinal_ulcer0.70771480
150MP0001324_abnormal_eye_pigmentation0.69459756
151MP0002075_abnormal_coat/hair_pigmentati0.69134725
152MP0002080_prenatal_lethality0.68837636
153MP0002229_neurodegeneration0.68326485
154MP0003315_abnormal_perineum_morphology0.67707115
155MP0008770_decreased_survivor_rate0.67422820
156MP0002752_abnormal_somatic_nervous0.67172781
157MP0003828_pulmonary_edema0.66652200
158MP0001697_abnormal_embryo_size0.63994963
159MP0001529_abnormal_vocalization0.61683268
160MP0002420_abnormal_adaptive_immunity0.61312112
161MP0002405_respiratory_system_inflammati0.56739724
162MP0001819_abnormal_immune_cell0.56133986
163MP0005385_cardiovascular_system_phenoty0.54922991
164MP0001544_abnormal_cardiovascular_syste0.54922991
165MP0001963_abnormal_hearing_physiology0.54859744
166MP0000685_abnormal_immune_system0.53344830
167MP0005193_abnormal_anterior_eye0.53209515

Predicted human phenotypes

RankGene SetZ-score
1Nuclear cataract (HP:0100018)6.38408755
2Zonular cataract (HP:0010920)5.62018959
3Myokymia (HP:0002411)4.91308631
4Hypothermia (HP:0002045)4.73937477
5Abnormality of the heme biosynthetic pathway (HP:0010472)4.52269188
6Ulnar claw (HP:0001178)4.35251588
7Petechiae (HP:0000967)4.25086242
8Agammaglobulinemia (HP:0004432)4.16781186
9Acute necrotizing encephalopathy (HP:0006965)3.96726992
10Febrile seizures (HP:0002373)3.93822589
11Abnormal number of erythroid precursors (HP:0012131)3.74741836
12Action tremor (HP:0002345)3.69194244
13Abnormality of cells of the erythroid lineage (HP:0012130)3.67021165
14Chromsome breakage (HP:0040012)3.64586052
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.59903560
16Acute encephalopathy (HP:0006846)3.58471412
17Abnormality of midbrain morphology (HP:0002418)3.53596936
18Molar tooth sign on MRI (HP:0002419)3.53596936
19Abnormal mitochondria in muscle tissue (HP:0008316)3.47441435
20Tongue fasciculations (HP:0001308)3.40574827
21Nephronophthisis (HP:0000090)3.40131341
22Pancreatic fibrosis (HP:0100732)3.29785041
23Cellulitis (HP:0100658)3.22602922
24Papilloma (HP:0012740)3.20589715
25Verrucae (HP:0200043)3.20589715
26Prolonged bleeding time (HP:0003010)3.19224234
27Acanthocytosis (HP:0001927)3.12444838
28Muscle fibrillation (HP:0010546)3.06352047
29Rib fusion (HP:0000902)3.04977558
30Progressive macrocephaly (HP:0004481)3.03171551
31Septo-optic dysplasia (HP:0100842)3.02430327
32Pancreatic cysts (HP:0001737)2.96639108
333-Methylglutaconic aciduria (HP:0003535)2.93450375
34True hermaphroditism (HP:0010459)2.89252004
35Delusions (HP:0000746)2.85054685
36Broad palm (HP:0001169)2.79064582
37Short middle phalanx of the 5th finger (HP:0004220)2.75613559
38Abnormality of DNA repair (HP:0003254)2.74462158
39Orthostatic hypotension (HP:0001278)2.74125720
40Overlapping toe (HP:0001845)2.73557731
41Hepatocellular necrosis (HP:0001404)2.72665840
42Abnormal ciliary motility (HP:0012262)2.72579319
43Abnormal respiratory motile cilium physiology (HP:0012261)2.70360299
44Abnormality of the renal medulla (HP:0100957)2.68870190
45Abnormality of the labia minora (HP:0012880)2.65218413
46Dysautonomia (HP:0002459)2.64781625
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.64087329
48Abnormality of the renal collecting system (HP:0004742)2.63832043
49Medial flaring of the eyebrow (HP:0010747)2.63111251
50Duplicated collecting system (HP:0000081)2.62497677
51Areflexia of lower limbs (HP:0002522)2.61631815
52Absent thumb (HP:0009777)2.60431692
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.59778195
54Sclerocornea (HP:0000647)2.57940062
55Impaired pain sensation (HP:0007328)2.55509686
56Abnormality of pain sensation (HP:0010832)2.55509686
57Microvesicular hepatic steatosis (HP:0001414)2.54645497
58Cerebral edema (HP:0002181)2.54140003
59Concave nail (HP:0001598)2.51911320
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49996844
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49996844
62Congenital cataract (HP:0000519)2.48248269
63B lymphocytopenia (HP:0010976)2.47630962
64Abnormality of B cell number (HP:0010975)2.47630962
65Hypoplasia of the pons (HP:0012110)2.47214152
66Neuroendocrine neoplasm (HP:0100634)2.46374199
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44641013
68Panhypogammaglobulinemia (HP:0003139)2.44589149
69Pheochromocytoma (HP:0002666)2.43724538
70Facial hemangioma (HP:0000329)2.38890303
71Ectopic kidney (HP:0000086)2.37649083
72Osteomyelitis (HP:0002754)2.37385938
73Cystic liver disease (HP:0006706)2.33809153
74Emotional lability (HP:0000712)2.33205607
75Abnormal respiratory epithelium morphology (HP:0012253)2.33103999
76Abnormal respiratory motile cilium morphology (HP:0005938)2.33103999
77Abnormality of the pons (HP:0007361)2.32934919
78Amblyopia (HP:0000646)2.32117518
79Triphalangeal thumb (HP:0001199)2.31984614
80Abnormality of the ileum (HP:0001549)2.31041633
81Meckel diverticulum (HP:0002245)2.30908152
82Hypercortisolism (HP:0001578)2.27695211
83Absent septum pellucidum (HP:0001331)2.26479620
84Abnormality of abdominal situs (HP:0011620)2.26323187
85Abdominal situs inversus (HP:0003363)2.26323187
86Atonic seizures (HP:0010819)2.24501858
87Abnormal biliary tract physiology (HP:0012439)2.24327826
88Bile duct proliferation (HP:0001408)2.24327826
89Chronic hepatic failure (HP:0100626)2.24005105
90Anencephaly (HP:0002323)2.23412191
91Akinesia (HP:0002304)2.22881233
92Fasciculations (HP:0002380)2.22791654
93Aplasia/Hypoplasia of the tongue (HP:0010295)2.22646422
94Growth hormone excess (HP:0000845)2.22429821
95Apathy (HP:0000741)2.22356514
96Poikilocytosis (HP:0004447)2.22294895
97Abnormality of dental color (HP:0011073)2.22194827
98Hypoplasia of the capital femoral epiphysis (HP:0003090)2.22059054
99Pallor (HP:0000980)2.21773058
100Stridor (HP:0010307)2.21314024
101Duplication of thumb phalanx (HP:0009942)2.20281975
102Birth length less than 3rd percentile (HP:0003561)2.20258376
103Diminished motivation (HP:0000745)2.18773027
104Optic disc pallor (HP:0000543)2.18638828
105Acute lymphatic leukemia (HP:0006721)2.18296175
106Congenital primary aphakia (HP:0007707)2.17565652
107Hepatic necrosis (HP:0002605)2.17109884
108Postaxial foot polydactyly (HP:0001830)2.16612133
109Abnormality of the aortic arch (HP:0012303)2.14605654
110Depressed nasal ridge (HP:0000457)2.11128789
111Absent/shortened dynein arms (HP:0200106)2.07793694
112Dynein arm defect of respiratory motile cilia (HP:0012255)2.07793694
113Gait imbalance (HP:0002141)2.06008390
114Tubulointerstitial nephritis (HP:0001970)2.05841783
115Abnormality of chromosome stability (HP:0003220)2.05837622
116Duodenal stenosis (HP:0100867)2.03612063
117Small intestinal stenosis (HP:0012848)2.03612063
118Abnormality of cochlea (HP:0000375)2.01499493
119Type I transferrin isoform profile (HP:0003642)2.00103717
120Abnormal autonomic nervous system physiology (HP:0012332)1.99693224
121Foot dorsiflexor weakness (HP:0009027)1.99436684
122Reticulocytosis (HP:0001923)1.99416091
123Severe visual impairment (HP:0001141)1.98174264
124Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97278201
125Cerebellar dysplasia (HP:0007033)1.97273295
126Generalized hypotonia (HP:0001290)1.95487391
127Polycythemia (HP:0001901)1.95464320
128Poor coordination (HP:0002370)1.95368216
129Short 5th finger (HP:0009237)1.94769402
130Congenital, generalized hypertrichosis (HP:0004540)1.94435292
131Aganglionic megacolon (HP:0002251)1.94373510
132Aplastic anemia (HP:0001915)1.94286809
133Increased hepatocellular lipid droplets (HP:0006565)1.94011388
134Testicular atrophy (HP:0000029)1.92778337
135Abnormality of the preputium (HP:0100587)1.92673691
136Self-mutilation (HP:0000742)1.92366586
137Abnormality of reticulocytes (HP:0004312)1.92188647
138Congenital stationary night blindness (HP:0007642)1.91772342
139Steppage gait (HP:0003376)1.91652147
140Neoplasm of the peripheral nervous system (HP:0100007)1.90549642
141Congenital hepatic fibrosis (HP:0002612)1.90116926
142Nephrogenic diabetes insipidus (HP:0009806)1.89494012
143Lipid accumulation in hepatocytes (HP:0006561)1.89369157
144Irregular epiphyses (HP:0010582)1.88213212
145Mitochondrial inheritance (HP:0001427)1.86883164
146Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.86496170
147Preaxial hand polydactyly (HP:0001177)1.86321017
148Partial duplication of thumb phalanx (HP:0009944)1.86231158
149Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85968936
150Rhinitis (HP:0012384)1.85390085
151Thrombocytosis (HP:0001894)1.85265489
152Postaxial hand polydactyly (HP:0001162)1.84693600
153Abnormality of the renal cortex (HP:0011035)1.84266882
154Respiratory failure (HP:0002878)1.84237635
155Holoprosencephaly (HP:0001360)1.83509556
156Increased serum lactate (HP:0002151)1.83440939
157Sloping forehead (HP:0000340)1.83256053
158Arthropathy (HP:0003040)1.82217710
159Horseshoe kidney (HP:0000085)1.82033413
160Fetal akinesia sequence (HP:0001989)1.81907705
161Patellar aplasia (HP:0006443)1.81765403
162Autoamputation (HP:0001218)1.81736556
163Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80314871
164Pulmonary fibrosis (HP:0002206)1.80166588
165Spastic gait (HP:0002064)1.79832341
166Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79672366
167Reticulocytopenia (HP:0001896)1.79339858
168Delayed gross motor development (HP:0002194)1.77670453
169Abnormality of the foot musculature (HP:0001436)1.77402400
170Poor suck (HP:0002033)1.75858690
171Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.75389168
172Abnormal rod and cone electroretinograms (HP:0008323)1.74516987
173Macrocytic anemia (HP:0001972)1.71904359
174Thyroiditis (HP:0100646)1.71164320
175Termporal pattern (HP:0011008)1.70702146
176Insidious onset (HP:0003587)1.70702146
177Increased CSF lactate (HP:0002490)1.69791471
178Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.69512541
179Cutaneous melanoma (HP:0012056)1.68285031
180Chronic otitis media (HP:0000389)1.68178096
181Failure to thrive in infancy (HP:0001531)1.67447195
182Cerebral hypomyelination (HP:0006808)1.66860824
183Meningitis (HP:0001287)1.65509035
184Segmental peripheral demyelination/remyelination (HP:0003481)1.63276459
185Breast hypoplasia (HP:0003187)1.63243041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK34.26244993
2SCYL24.20113951
3VRK23.16645352
4MATK3.11486775
5MINK12.94416063
6NUAK12.89635547
7ZAK2.78649456
8CASK2.77693975
9PLK42.55987727
10SIK32.54281966
11MAP3K112.49773961
12PASK2.48061763
13RPS6KB22.35833530
14PNCK2.35242751
15NEK92.34110876
16EEF2K2.33957352
17MAP3K102.27627443
18TAOK32.14120365
19WNK42.08769206
20MAPK132.05682226
21BCKDK2.03269752
22MAP4K12.02393845
23NTRK32.01967892
24YES11.95704420
25NTRK11.90009120
26STK161.80466924
27CDC71.77856790
28CDK191.76540142
29WEE11.70840522
30TTK1.55700886
31LRRK21.46489120
32RPS6KA21.46038332
33BUB11.45146854
34NEK21.43910983
35TESK21.40748870
36ATR1.38350278
37NEK11.36842370
38EIF2AK11.33197759
39SYK1.29171999
40RPS6KC11.29037235
41RPS6KL11.29037235
42PIM21.26348965
43LIMK11.26243675
44AURKA1.24546906
45MARK31.23845780
46PINK11.22911465
47BRSK11.20523322
48NTRK21.20474043
49MST41.20462571
50TNK21.19496027
51RPS6KA61.17413859
52SGK21.16191056
53NME11.15898072
54AURKB1.15808524
55MAP3K71.15474594
56ADRBK21.14637650
57FLT31.14470880
58MAPK151.12591907
59NME21.11115162
60KIT1.10934817
61TAF11.08772700
62MAP3K121.08631596
63PIM11.05642032
64VRK11.03524153
65GRK61.02791753
66STK241.02099030
67PLK31.01401208
68TYRO30.98762128
69TIE10.98159510
70EPHB20.97930134
71BRSK20.97816921
72MAP4K20.96555853
73DMPK0.95048551
74LMTK20.92077075
75CDK30.89128866
76GRK10.88922094
77BTK0.86625668
78CSF1R0.85055587
79BMPR1B0.84302968
80FGFR20.82867267
81UHMK10.81749199
82WNK30.81385848
83CDK40.78912481
84PTK2B0.77661663
85TGFBR10.77593626
86PDK20.75837706
87CCNB10.73914390
88MAP2K70.73829330
89ADRBK10.73424281
90STK390.72554907
91MKNK20.72378334
92PIK3CA0.71475428
93SGK30.70822128
94ATM0.70015317
95BMX0.69358744
96CDK70.69214262
97BRAF0.68011279
98PRKCQ0.67547403
99MAPKAPK50.66663155
100FES0.65765105
101CDK80.64478142
102STK30.64116233
103MAPK110.64080386
104PRKCH0.63896492
105GRK70.62909649
106MAP2K60.62824400
107MAP2K10.62102396
108CHEK10.61804362
109SGK4940.61269972
110SGK2230.61269972
111HIPK20.60113421
112MAPKAPK20.59154425
113DYRK20.59096177
114CAMK1G0.58746290
115PRKCG0.58275699
116INSRR0.58168086
117MAP3K40.57751780
118STK100.57602781
119RPS6KB10.57527516
120PKN20.57167639
121MKNK10.56867338
122CSNK1E0.56832413
123KDR0.56395604
124TLK10.55625145
125PTK60.54301595
126CAMK10.52815614
127CDK10.52135899
128OXSR10.50426576
129MAP3K130.50283750
130DYRK1B0.50270264
131CSNK2A20.48085880
132PBK0.47991553
133SRPK10.46211555
134STK40.46098500
135WNK10.46023466
136TEC0.45756204
137MAPK40.45474671
138ZAP700.45384109
139STK110.44561983
140PRPF4B0.43677080
141DYRK30.43411920
142CSNK1A10.43364470
143PLK10.43230953
144CDK140.41812045
145PIK3CG0.41137547
146ROCK20.40746222
147CDK180.39158369
148AKT10.37709471
149LYN0.37547477
150MAPK30.36951891
151PRKD30.35166287
152PRKACB0.34086207
153CHEK20.33817692
154CDK11A0.33028875
155CDK20.32858314
156PRKG20.31733714
157MAP2K30.31337197
158CLK10.28288366
159TBK10.27719500
160MAP2K40.27709391
161MAP3K80.27024341
162CSNK2A10.26992730

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.16999379
2Mismatch repair_Homo sapiens_hsa034303.48366624
3Proteasome_Homo sapiens_hsa030503.26414728
4Ribosome_Homo sapiens_hsa030103.24089501
5Base excision repair_Homo sapiens_hsa034103.14559002
6Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.97221212
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.47812887
8Non-homologous end-joining_Homo sapiens_hsa034502.20627804
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12628980
10Cell cycle_Homo sapiens_hsa041102.10283846
11Protein export_Homo sapiens_hsa030602.09929556
12Spliceosome_Homo sapiens_hsa030401.95583521
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.94330941
14Parkinsons disease_Homo sapiens_hsa050121.93379589
15Homologous recombination_Homo sapiens_hsa034401.86286906
16Thyroid cancer_Homo sapiens_hsa052161.84383480
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80102651
18Nucleotide excision repair_Homo sapiens_hsa034201.79779438
19RNA polymerase_Homo sapiens_hsa030201.74656383
20Linoleic acid metabolism_Homo sapiens_hsa005911.72610110
21Pyrimidine metabolism_Homo sapiens_hsa002401.70703294
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70497845
23Primary immunodeficiency_Homo sapiens_hsa053401.70296374
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54075135
25Epstein-Barr virus infection_Homo sapiens_hsa051691.52894079
26B cell receptor signaling pathway_Homo sapiens_hsa046621.48214770
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47919794
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47625200
29Oocyte meiosis_Homo sapiens_hsa041141.46703816
30Oxidative phosphorylation_Homo sapiens_hsa001901.42777442
31RNA transport_Homo sapiens_hsa030131.41471712
32Huntingtons disease_Homo sapiens_hsa050161.39463490
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.37788781
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37668900
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33349819
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.33207933
37Butanoate metabolism_Homo sapiens_hsa006501.31010461
38Olfactory transduction_Homo sapiens_hsa047401.26026717
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23732772
40Phototransduction_Homo sapiens_hsa047441.23587279
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20339476
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.19468423
43Alzheimers disease_Homo sapiens_hsa050101.12069852
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06299265
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03694914
46Basal cell carcinoma_Homo sapiens_hsa052170.98686954
47Synaptic vesicle cycle_Homo sapiens_hsa047210.92203991
48Ether lipid metabolism_Homo sapiens_hsa005650.91073076
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90582679
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90284001
51Shigellosis_Homo sapiens_hsa051310.88468234
52Pentose phosphate pathway_Homo sapiens_hsa000300.88000779
53Acute myeloid leukemia_Homo sapiens_hsa052210.87975773
54mRNA surveillance pathway_Homo sapiens_hsa030150.87271945
55Colorectal cancer_Homo sapiens_hsa052100.86556562
56Cardiac muscle contraction_Homo sapiens_hsa042600.85890254
57ErbB signaling pathway_Homo sapiens_hsa040120.82438071
58Nitrogen metabolism_Homo sapiens_hsa009100.82103842
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80877044
60Fat digestion and absorption_Homo sapiens_hsa049750.80232307
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79767497
62Folate biosynthesis_Homo sapiens_hsa007900.78981827
63Glutathione metabolism_Homo sapiens_hsa004800.76739976
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76115411
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75864089
66Selenocompound metabolism_Homo sapiens_hsa004500.75305201
67Metabolic pathways_Homo sapiens_hsa011000.74507796
68Viral carcinogenesis_Homo sapiens_hsa052030.73474171
69Chemical carcinogenesis_Homo sapiens_hsa052040.72823831
70Platelet activation_Homo sapiens_hsa046110.72411936
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72216761
72Purine metabolism_Homo sapiens_hsa002300.71498732
73Endometrial cancer_Homo sapiens_hsa052130.71248703
74One carbon pool by folate_Homo sapiens_hsa006700.71066446
75Asthma_Homo sapiens_hsa053100.69516097
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.69126211
77Salmonella infection_Homo sapiens_hsa051320.68208278
78Alcoholism_Homo sapiens_hsa050340.67420893
79Non-small cell lung cancer_Homo sapiens_hsa052230.67287815
80Basal transcription factors_Homo sapiens_hsa030220.66182822
81Arachidonic acid metabolism_Homo sapiens_hsa005900.66180578
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65560620
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65221759
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63791821
85Pyruvate metabolism_Homo sapiens_hsa006200.62839233
86Melanoma_Homo sapiens_hsa052180.62610882
87Endocytosis_Homo sapiens_hsa041440.61709935
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60890356
89Hedgehog signaling pathway_Homo sapiens_hsa043400.60845480
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60557609
91Chronic myeloid leukemia_Homo sapiens_hsa052200.60501688
92Insulin signaling pathway_Homo sapiens_hsa049100.60179060
93Dopaminergic synapse_Homo sapiens_hsa047280.59722446
94p53 signaling pathway_Homo sapiens_hsa041150.59177492
95Hematopoietic cell lineage_Homo sapiens_hsa046400.58947845
96Glioma_Homo sapiens_hsa052140.57346118
97RNA degradation_Homo sapiens_hsa030180.56093687
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.55768648
99Peroxisome_Homo sapiens_hsa041460.55320928
100Propanoate metabolism_Homo sapiens_hsa006400.54197246
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53928978
102VEGF signaling pathway_Homo sapiens_hsa043700.53913512
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.53629476
104Nicotine addiction_Homo sapiens_hsa050330.52531436
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.51747253
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51387609
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.50565809
108Apoptosis_Homo sapiens_hsa042100.48786214
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48536429
110N-Glycan biosynthesis_Homo sapiens_hsa005100.48239204
111Tyrosine metabolism_Homo sapiens_hsa003500.47132254
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45937339
113Prolactin signaling pathway_Homo sapiens_hsa049170.44237735
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43379873
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.42081106
116Systemic lupus erythematosus_Homo sapiens_hsa053220.41464531
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41246509
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.39968712
119Fanconi anemia pathway_Homo sapiens_hsa034600.39322623
120Gap junction_Homo sapiens_hsa045400.38979767
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38051839
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37366488
123Measles_Homo sapiens_hsa051620.36985959
124Ovarian steroidogenesis_Homo sapiens_hsa049130.36509930
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36456727
126Steroid biosynthesis_Homo sapiens_hsa001000.35763772
127HIF-1 signaling pathway_Homo sapiens_hsa040660.35531008
128HTLV-I infection_Homo sapiens_hsa051660.31777496
129Pathways in cancer_Homo sapiens_hsa052000.31574762
130Taste transduction_Homo sapiens_hsa047420.30655922
131Regulation of autophagy_Homo sapiens_hsa041400.30629795
132Herpes simplex infection_Homo sapiens_hsa051680.29425535
133MAPK signaling pathway_Homo sapiens_hsa040100.28861013
134Glycerolipid metabolism_Homo sapiens_hsa005610.28338355
135Tryptophan metabolism_Homo sapiens_hsa003800.26558486
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26535761
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26442410
138Retinol metabolism_Homo sapiens_hsa008300.26297872
139Cholinergic synapse_Homo sapiens_hsa047250.26052834
140Sulfur relay system_Homo sapiens_hsa041220.23946914
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.23877389
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23714434
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23219788
144Hepatitis B_Homo sapiens_hsa051610.23062608
145Glucagon signaling pathway_Homo sapiens_hsa049220.22556086
146Pancreatic cancer_Homo sapiens_hsa052120.22003630
147Lysine degradation_Homo sapiens_hsa003100.17746948
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17561651
149Fatty acid elongation_Homo sapiens_hsa000620.15035426
150beta-Alanine metabolism_Homo sapiens_hsa004100.14259133
151Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12999586
152Vitamin digestion and absorption_Homo sapiens_hsa049770.11359365
153Notch signaling pathway_Homo sapiens_hsa043300.08394684
154Wnt signaling pathway_Homo sapiens_hsa043100.06743612
155Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05424979
156Phenylalanine metabolism_Homo sapiens_hsa003600.03255218

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