

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitotic metaphase plate congression (GO:0007080) | 5.75513110 |
| 2 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 5.67090653 |
| 3 | mitotic sister chromatid segregation (GO:0000070) | 5.20691723 |
| 4 | regulation of spindle organization (GO:0090224) | 5.08885561 |
| 5 | protein localization to kinetochore (GO:0034501) | 5.06545546 |
| 6 | metaphase plate congression (GO:0051310) | 4.79517239 |
| 7 | purine nucleobase biosynthetic process (GO:0009113) | 4.76466257 |
| 8 | protein localization to chromosome, centromeric region (GO:0071459) | 4.64320589 |
| 9 | sister chromatid segregation (GO:0000819) | 4.61008428 |
| 10 | nucleobase biosynthetic process (GO:0046112) | 4.55995870 |
| 11 | proline biosynthetic process (GO:0006561) | 4.49390214 |
| 12 | regulation of translational fidelity (GO:0006450) | 4.41583476 |
| 13 | kinetochore organization (GO:0051383) | 4.32011591 |
| 14 | kinetochore assembly (GO:0051382) | 4.30454521 |
| 15 | establishment of chromosome localization (GO:0051303) | 4.22992383 |
| 16 | spindle checkpoint (GO:0031577) | 4.22950070 |
| 17 | DNA deamination (GO:0045006) | 4.19476814 |
| 18 | positive regulation of chromosome segregation (GO:0051984) | 4.19316294 |
| 19 | DNA replication checkpoint (GO:0000076) | 4.14235358 |
| 20 | regulation of mitotic spindle organization (GO:0060236) | 4.12508011 |
| 21 | maturation of SSU-rRNA (GO:0030490) | 4.12412356 |
| 22 | regulation of chromosome segregation (GO:0051983) | 4.11001491 |
| 23 | negative regulation of chromosome segregation (GO:0051985) | 4.10875177 |
| 24 | ribosome assembly (GO:0042255) | 4.10422242 |
| 25 | CENP-A containing nucleosome assembly (GO:0034080) | 4.10035382 |
| 26 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 4.05804469 |
| 27 | negative regulation of sister chromatid segregation (GO:0033046) | 4.05804469 |
| 28 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 4.05804469 |
| 29 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 4.05804469 |
| 30 | spindle assembly checkpoint (GO:0071173) | 4.04651709 |
| 31 | mitotic spindle assembly checkpoint (GO:0007094) | 4.04000348 |
| 32 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.02065279 |
| 33 | mitotic spindle checkpoint (GO:0071174) | 3.99857539 |
| 34 | DNA topological change (GO:0006265) | 3.99234283 |
| 35 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.96687322 |
| 36 | mitotic nuclear envelope disassembly (GO:0007077) | 3.94694581 |
| 37 | nuclear pore complex assembly (GO:0051292) | 3.94397874 |
| 38 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.93219372 |
| 39 | DNA replication initiation (GO:0006270) | 3.92473039 |
| 40 | chromatin remodeling at centromere (GO:0031055) | 3.92347352 |
| 41 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.88936794 |
| 42 | protein complex localization (GO:0031503) | 3.88768319 |
| 43 | mitotic chromosome condensation (GO:0007076) | 3.83362973 |
| 44 | ribosome biogenesis (GO:0042254) | 3.82956026 |
| 45 | DNA strand elongation (GO:0022616) | 3.81292822 |
| 46 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.79932061 |
| 47 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.76476744 |
| 48 | chromosome condensation (GO:0030261) | 3.76166921 |
| 49 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.74659182 |
| 50 | DNA replication-independent nucleosome organization (GO:0034724) | 3.74659182 |
| 51 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 3.72353558 |
| 52 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.71308576 |
| 53 | protein localization to chromosome (GO:0034502) | 3.68338648 |
| 54 | proteasome assembly (GO:0043248) | 3.67791091 |
| 55 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.67418436 |
| 56 | spliceosomal snRNP assembly (GO:0000387) | 3.66799388 |
| 57 | formation of translation preinitiation complex (GO:0001731) | 3.64748520 |
| 58 | nuclear envelope disassembly (GO:0051081) | 3.63540798 |
| 59 | membrane disassembly (GO:0030397) | 3.63540798 |
| 60 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.61825402 |
| 61 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.61825402 |
| 62 | regulation of sister chromatid segregation (GO:0033045) | 3.61825402 |
| 63 | heterochromatin organization (GO:0070828) | 3.59863860 |
| 64 | regulation of exit from mitosis (GO:0007096) | 3.59859398 |
| 65 | DNA unwinding involved in DNA replication (GO:0006268) | 3.57272376 |
| 66 | ribosomal large subunit biogenesis (GO:0042273) | 3.55875343 |
| 67 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.55333321 |
| 68 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.54911876 |
| 69 | histone exchange (GO:0043486) | 3.52256871 |
| 70 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.49643764 |
| 71 | microtubule depolymerization (GO:0007019) | 3.49147078 |
| 72 | cellular protein complex localization (GO:0034629) | 3.46346721 |
| 73 | folic acid metabolic process (GO:0046655) | 3.43518924 |
| 74 | nuclear pore organization (GO:0006999) | 3.39310456 |
| 75 | chromosome segregation (GO:0007059) | 3.39277278 |
| 76 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.37627190 |
| 77 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.37205190 |
| 78 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.37205190 |
| 79 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.37205190 |
| 80 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.37183767 |
| 81 | rRNA processing (GO:0006364) | 3.36531522 |
| 82 | regulation of translational termination (GO:0006449) | 3.35857565 |
| 83 | rRNA modification (GO:0000154) | 3.33710439 |
| 84 | mitotic recombination (GO:0006312) | 3.32673177 |
| 85 | telomere maintenance via recombination (GO:0000722) | 3.32497774 |
| 86 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.31937138 |
| 87 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.31937138 |
| 88 | spliceosomal complex assembly (GO:0000245) | 3.30093496 |
| 89 | negative regulation of mitosis (GO:0045839) | 3.29952232 |
| 90 | regulation of centrosome cycle (GO:0046605) | 3.28482847 |
| 91 | rRNA metabolic process (GO:0016072) | 3.27527660 |
| 92 | termination of RNA polymerase III transcription (GO:0006386) | 3.24302959 |
| 93 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.24302959 |
| 94 | translational initiation (GO:0006413) | 3.23234728 |
| 95 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.21582932 |
| 96 | viral transcription (GO:0019083) | 3.18100257 |
| 97 | DNA packaging (GO:0006323) | 3.17974407 |
| 98 | regulation of telomere maintenance via telomerase (GO:0032210) | 3.17712966 |
| 99 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.16280255 |
| 100 | histone-serine phosphorylation (GO:0035404) | 3.16196256 |
| 101 | ribosomal small subunit assembly (GO:0000028) | 3.16074454 |
| 102 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.16048463 |
| 103 | activation of Rac GTPase activity (GO:0032863) | 3.14681008 |
| 104 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.13919929 |
| 105 | translational termination (GO:0006415) | 3.13709724 |
| 106 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.12699693 |
| 107 | protein K6-linked ubiquitination (GO:0085020) | 3.11357100 |
| 108 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.10970080 |
| 109 | nuclear envelope organization (GO:0006998) | 3.08712197 |
| 110 | telomere maintenance via telomere lengthening (GO:0010833) | 3.08543202 |
| 111 | viral mRNA export from host cell nucleus (GO:0046784) | 3.08394894 |
| 112 | ribosomal small subunit biogenesis (GO:0042274) | 3.08036420 |
| 113 | translational elongation (GO:0006414) | 3.07466678 |
| 114 | rRNA transcription (GO:0009303) | 3.06060423 |
| 115 | negative regulation of ligase activity (GO:0051352) | 3.05119710 |
| 116 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.05119710 |
| 117 | proline metabolic process (GO:0006560) | 3.04003613 |
| 118 | DNA duplex unwinding (GO:0032508) | 3.03911564 |
| 119 | establishment of integrated proviral latency (GO:0075713) | 3.03862782 |
| 120 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 3.01754459 |
| 121 | negative regulation of DNA-templated transcription, elongation (GO:0032785) | 3.01754459 |
| 122 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.99762050 |
| 123 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.99635896 |
| 124 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435) | 2.98282706 |
| 125 | DNA conformation change (GO:0071103) | 2.97819236 |
| 126 | mitotic sister chromatid cohesion (GO:0007064) | 2.97137814 |
| 127 | regulation of sister chromatid cohesion (GO:0007063) | 2.95433056 |
| 128 | pore complex assembly (GO:0046931) | 2.94122561 |
| 129 | negative regulation of mRNA processing (GO:0050686) | 2.89105302 |
| 130 | desmosome organization (GO:0002934) | 2.88864594 |
| 131 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 2.88249690 |
| 132 | DNA geometric change (GO:0032392) | 2.87952873 |
| 133 | negative regulation of mRNA metabolic process (GO:1903312) | 2.87341233 |
| 134 | histone arginine methylation (GO:0034969) | 2.84725770 |
| 135 | Golgi transport vesicle coating (GO:0048200) | 2.84588786 |
| 136 | COPI coating of Golgi vesicle (GO:0048205) | 2.84588786 |
| 137 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.79282640 |
| 138 | viral life cycle (GO:0019058) | 2.79157685 |
| 139 | nucleosome disassembly (GO:0006337) | 2.77973013 |
| 140 | protein-DNA complex disassembly (GO:0032986) | 2.77973013 |
| 141 | maternal placenta development (GO:0001893) | 2.75943220 |
| 142 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.75171383 |
| 143 | cotranslational protein targeting to membrane (GO:0006613) | 2.74909196 |
| 144 | cellular protein complex disassembly (GO:0043624) | 2.74451220 |
| 145 | chromatin assembly or disassembly (GO:0006333) | 2.74259991 |
| 146 | negative regulation of RNA splicing (GO:0033119) | 2.72984023 |
| 147 | protein targeting to ER (GO:0045047) | 2.71655823 |
| 148 | protein complex disassembly (GO:0043241) | 2.70344097 |
| 149 | regulation of chromatin binding (GO:0035561) | 2.68919923 |
| 150 | chromatin assembly (GO:0031497) | 2.68340464 |
| 151 | nuclear envelope reassembly (GO:0031468) | 2.67191964 |
| 152 | mitotic nuclear envelope reassembly (GO:0007084) | 2.67191964 |
| 153 | apoptotic process involved in morphogenesis (GO:0060561) | 2.65997333 |
| 154 | ncRNA 3-end processing (GO:0043628) | 2.64831506 |
| 155 | positive regulation of DNA-dependent DNA replication (GO:2000105) | 2.64155469 |
| 156 | regulation of mitochondrial translation (GO:0070129) | 2.63940736 |
| 157 | L-serine metabolic process (GO:0006563) | 2.61005600 |
| 158 | establishment of apical/basal cell polarity (GO:0035089) | 2.60566890 |
| 159 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.59739965 |
| 160 | peptidyl-arginine methylation (GO:0018216) | 2.58452744 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.41556779 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 6.47959475 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.06992648 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.94563733 |
| 5 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.87255537 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.49710164 |
| 7 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.29489919 |
| 8 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.06999805 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.01982722 |
| 10 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.95093821 |
| 11 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.92375804 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.84830574 |
| 13 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.84785681 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.84642324 |
| 15 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.80691669 |
| 16 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.63908241 |
| 17 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.47227488 |
| 18 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.43849963 |
| 19 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.42702448 |
| 20 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.25729690 |
| 21 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.22197427 |
| 22 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.16814192 |
| 23 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.06421801 |
| 24 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.06256755 |
| 25 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.03051914 |
| 26 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.01774399 |
| 27 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 2.01600087 |
| 28 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.91076035 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.89570296 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.88752360 |
| 31 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.88089582 |
| 32 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.87892533 |
| 33 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.87280433 |
| 34 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.85661591 |
| 35 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.83632058 |
| 36 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.83355060 |
| 37 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.81493599 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.78929665 |
| 39 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.78903649 |
| 40 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.77893736 |
| 41 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.76559873 |
| 42 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.75742106 |
| 43 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.70329113 |
| 44 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.61384572 |
| 45 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.59103660 |
| 46 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.58176982 |
| 47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.53595410 |
| 48 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.50540592 |
| 49 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.49241533 |
| 50 | MYC_22102868_ChIP-Seq_BL_Human | 1.49096514 |
| 51 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.48964662 |
| 52 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.48008209 |
| 53 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.46894598 |
| 54 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.46463985 |
| 55 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.43853301 |
| 56 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.43649329 |
| 57 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.40825110 |
| 58 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.37827607 |
| 59 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.37053620 |
| 60 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.36201847 |
| 61 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.31319054 |
| 62 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.30901802 |
| 63 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.30416339 |
| 64 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.29859289 |
| 65 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29287609 |
| 66 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.27270684 |
| 67 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.27080780 |
| 68 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.26487733 |
| 69 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.24201991 |
| 70 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.23143646 |
| 71 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.22309641 |
| 72 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.22173833 |
| 73 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.21854915 |
| 74 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.21697010 |
| 75 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.21263226 |
| 76 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.18208388 |
| 77 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.16227354 |
| 78 | ATF3_27146783_Chip-Seq_COLON_Human | 1.15325486 |
| 79 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.14665243 |
| 80 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.14623726 |
| 81 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.13861959 |
| 82 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.13723978 |
| 83 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.13594959 |
| 84 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.12281939 |
| 85 | CHD1_26751641_Chip-Seq_LNCaP_Human | 1.11860568 |
| 86 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.11854324 |
| 87 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.11758619 |
| 88 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.10630655 |
| 89 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10553373 |
| 90 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.10538584 |
| 91 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.09490259 |
| 92 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.09362740 |
| 93 | P68_20966046_ChIP-Seq_HELA_Human | 1.08882041 |
| 94 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.05925050 |
| 95 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.01929177 |
| 96 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.01294724 |
| 97 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.01172469 |
| 98 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.00335067 |
| 99 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.99198942 |
| 100 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.98164428 |
| 101 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.97769367 |
| 102 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.97521307 |
| 103 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.96885928 |
| 104 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.96435336 |
| 105 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.94442340 |
| 106 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.94271070 |
| 107 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.93469523 |
| 108 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93321808 |
| 109 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.93219694 |
| 110 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.92821107 |
| 111 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.92724248 |
| 112 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.92205021 |
| 113 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.91982293 |
| 114 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.91407031 |
| 115 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.90832772 |
| 116 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.89793650 |
| 117 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.89573214 |
| 118 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.88615874 |
| 119 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.88146436 |
| 120 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.83441306 |
| 121 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.82486175 |
| 122 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.81376301 |
| 123 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.80912905 |
| 124 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.80854791 |
| 125 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.78926520 |
| 126 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.77290467 |
| 127 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.76931687 |
| 128 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.76223575 |
| 129 | POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.75654695 |
| 130 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.75361476 |
| 131 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.73646545 |
| 132 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.73579356 |
| 133 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.72925592 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 6.98539930 |
| 2 | MP0003111_abnormal_nucleus_morphology | 5.71230844 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.63488036 |
| 4 | MP0003077_abnormal_cell_cycle | 4.43977111 |
| 5 | MP0010094_abnormal_chromosome_stability | 4.41764161 |
| 6 | MP0010234_abnormal_vibrissa_follicle | 4.25690497 |
| 7 | MP0008057_abnormal_DNA_replication | 3.14786728 |
| 8 | MP0003705_abnormal_hypodermis_morpholog | 3.00682857 |
| 9 | MP0008058_abnormal_DNA_repair | 3.00152235 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.92135649 |
| 11 | MP0008007_abnormal_cellular_replicative | 2.70449962 |
| 12 | MP0003718_maternal_effect | 2.56841122 |
| 13 | MP0001730_embryonic_growth_arrest | 2.50348706 |
| 14 | MP0004185_abnormal_adipocyte_glucose | 2.32515224 |
| 15 | MP0003786_premature_aging | 2.27584302 |
| 16 | MP0002796_impaired_skin_barrier | 2.26569758 |
| 17 | MP0000350_abnormal_cell_proliferation | 2.24589452 |
| 18 | MP0005451_abnormal_body_composition | 2.24275236 |
| 19 | MP0005501_abnormal_skin_physiology | 2.07885363 |
| 20 | MP0003123_paternal_imprinting | 2.06628482 |
| 21 | MP0002877_abnormal_melanocyte_morpholog | 2.01610860 |
| 22 | MP0001672_abnormal_embryogenesis/_devel | 1.94932866 |
| 23 | MP0005380_embryogenesis_phenotype | 1.94932866 |
| 24 | MP0002396_abnormal_hematopoietic_system | 1.85033909 |
| 25 | MP0009379_abnormal_foot_pigmentation | 1.84582203 |
| 26 | MP0003878_abnormal_ear_physiology | 1.83110354 |
| 27 | MP0005377_hearing/vestibular/ear_phenot | 1.83110354 |
| 28 | MP0010307_abnormal_tumor_latency | 1.80805748 |
| 29 | MP0001697_abnormal_embryo_size | 1.80089228 |
| 30 | MP0010030_abnormal_orbit_morphology | 1.79684778 |
| 31 | MP0004233_abnormal_muscle_weight | 1.71253905 |
| 32 | MP0008260_abnormal_autophagy | 1.69742174 |
| 33 | MP0002080_prenatal_lethality | 1.69625898 |
| 34 | MP0002098_abnormal_vibrissa_morphology | 1.68711685 |
| 35 | MP0004264_abnormal_extraembryonic_tissu | 1.67222959 |
| 36 | MP0002085_abnormal_embryonic_tissue | 1.66827959 |
| 37 | MP0003984_embryonic_growth_retardation | 1.64948106 |
| 38 | MP0002088_abnormal_embryonic_growth/wei | 1.61613371 |
| 39 | MP0001346_abnormal_lacrimal_gland | 1.59443728 |
| 40 | MP0002249_abnormal_larynx_morphology | 1.57200355 |
| 41 | MP0008877_abnormal_DNA_methylation | 1.49531447 |
| 42 | MP0000490_abnormal_crypts_of | 1.47246656 |
| 43 | MP0002653_abnormal_ependyma_morphology | 1.44160014 |
| 44 | MP0000313_abnormal_cell_death | 1.43810491 |
| 45 | MP0003938_abnormal_ear_development | 1.43441877 |
| 46 | MP0002084_abnormal_developmental_patter | 1.39399215 |
| 47 | MP0000678_abnormal_parathyroid_gland | 1.38760628 |
| 48 | MP0003453_abnormal_keratinocyte_physiol | 1.36396445 |
| 49 | MP0009333_abnormal_splenocyte_physiolog | 1.36077164 |
| 50 | MP0002102_abnormal_ear_morphology | 1.32831746 |
| 51 | MP0002086_abnormal_extraembryonic_tissu | 1.32594182 |
| 52 | MP0003567_abnormal_fetal_cardiomyocyte | 1.30072564 |
| 53 | MP0003941_abnormal_skin_development | 1.29259130 |
| 54 | MP0003942_abnormal_urinary_system | 1.27414298 |
| 55 | MP0002697_abnormal_eye_size | 1.27095593 |
| 56 | MP0002019_abnormal_tumor_incidence | 1.26293817 |
| 57 | MP0000579_abnormal_nail_morphology | 1.25784850 |
| 58 | MP0009840_abnormal_foam_cell | 1.24874972 |
| 59 | MP0001545_abnormal_hematopoietic_system | 1.24581202 |
| 60 | MP0005397_hematopoietic_system_phenotyp | 1.24581202 |
| 61 | MP0001849_ear_inflammation | 1.22931621 |
| 62 | MP0004858_abnormal_nervous_system | 1.22394016 |
| 63 | MP0003315_abnormal_perineum_morphology | 1.21834838 |
| 64 | MP0002210_abnormal_sex_determination | 1.20838812 |
| 65 | MP0009278_abnormal_bone_marrow | 1.19164616 |
| 66 | MP0004808_abnormal_hematopoietic_stem | 1.17088506 |
| 67 | MP0010352_gastrointestinal_tract_polyps | 1.16294161 |
| 68 | MP0004782_abnormal_surfactant_physiolog | 1.13453527 |
| 69 | MP0010678_abnormal_skin_adnexa | 1.12985260 |
| 70 | MP0001293_anophthalmia | 1.12059469 |
| 71 | MP0006292_abnormal_olfactory_placode | 1.11189880 |
| 72 | MP0000566_synostosis | 1.09679595 |
| 73 | MP0003119_abnormal_digestive_system | 1.08363187 |
| 74 | MP0001145_abnormal_male_reproductive | 1.07724893 |
| 75 | MP0005257_abnormal_intraocular_pressure | 1.07409837 |
| 76 | MP0003937_abnormal_limbs/digits/tail_de | 1.05204460 |
| 77 | MP0005666_abnormal_adipose_tissue | 1.04622038 |
| 78 | MP0002132_abnormal_respiratory_system | 1.03885222 |
| 79 | MP0004197_abnormal_fetal_growth/weight/ | 1.01361001 |
| 80 | MP0001348_abnormal_lacrimal_gland | 1.00473079 |
| 81 | MP0001929_abnormal_gametogenesis | 0.99823153 |
| 82 | MP0000467_abnormal_esophagus_morphology | 0.99371881 |
| 83 | MP0000377_abnormal_hair_follicle | 0.99241605 |
| 84 | MP0002089_abnormal_postnatal_growth/wei | 0.98643068 |
| 85 | MP0001216_abnormal_epidermal_layer | 0.98107147 |
| 86 | MP0000428_abnormal_craniofacial_morphol | 0.97576994 |
| 87 | MP0000762_abnormal_tongue_morphology | 0.97520221 |
| 88 | MP0009672_abnormal_birth_weight | 0.96351261 |
| 89 | MP0002111_abnormal_tail_morphology | 0.94100807 |
| 90 | MP0000627_abnormal_mammary_gland | 0.93842250 |
| 91 | MP0000703_abnormal_thymus_morphology | 0.92905351 |
| 92 | MP0000462_abnormal_digestive_system | 0.92811315 |
| 93 | MP0005076_abnormal_cell_differentiation | 0.92179055 |
| 94 | MP0009053_abnormal_anal_canal | 0.91821362 |
| 95 | MP0000537_abnormal_urethra_morphology | 0.89407838 |
| 96 | MP0000534_abnormal_ureter_morphology | 0.89381156 |
| 97 | MP0000653_abnormal_sex_gland | 0.89103730 |
| 98 | MP0005389_reproductive_system_phenotype | 0.88455546 |
| 99 | MP0010771_integument_phenotype | 0.87022941 |
| 100 | MP0005409_darkened_coat_color | 0.83726568 |
| 101 | MP0003221_abnormal_cardiomyocyte_apopto | 0.83415701 |
| 102 | MP0001919_abnormal_reproductive_system | 0.81861435 |
| 103 | MP0002160_abnormal_reproductive_system | 0.81703958 |
| 104 | MP0002722_abnormal_immune_system | 0.81252256 |
| 105 | MP0001881_abnormal_mammary_gland | 0.80227150 |
| 106 | MP0002060_abnormal_skin_morphology | 0.80062856 |
| 107 | MP0001727_abnormal_embryo_implantation | 0.77543200 |
| 108 | MP0003890_abnormal_embryonic-extraembry | 0.77458123 |
| 109 | MP0002092_abnormal_eye_morphology | 0.75656921 |
| 110 | MP0000477_abnormal_intestine_morphology | 0.75190377 |
| 111 | MP0005621_abnormal_cell_physiology | 0.73507141 |
| 112 | MP0001873_stomach_inflammation | 0.72937989 |
| 113 | MP0000358_abnormal_cell_content/ | 0.72150094 |
| 114 | MP0006035_abnormal_mitochondrial_morpho | 0.72068517 |
| 115 | MP0001340_abnormal_eyelid_morphology | 0.71209384 |
| 116 | MP0003566_abnormal_cell_adhesion | 0.70952343 |
| 117 | MP0001286_abnormal_eye_development | 0.70080032 |
| 118 | MP0005384_cellular_phenotype | 0.69956064 |
| 119 | MP0001119_abnormal_female_reproductive | 0.69207709 |
| 120 | MP0003385_abnormal_body_wall | 0.68463746 |
| 121 | MP0000049_abnormal_middle_ear | 0.68303591 |
| 122 | MP0000689_abnormal_spleen_morphology | 0.68009018 |
| 123 | MP0000750_abnormal_muscle_regeneration | 0.67916527 |
| 124 | MP0002398_abnormal_bone_marrow | 0.67465592 |
| 125 | MP0002751_abnormal_autonomic_nervous | 0.67098076 |
| 126 | MP0001661_extended_life_span | 0.66059041 |
| 127 | MP0009703_decreased_birth_body | 0.65554486 |
| 128 | MP0005395_other_phenotype | 0.64055837 |
| 129 | MP0003699_abnormal_female_reproductive | 0.63763620 |
| 130 | MP0003136_yellow_coat_color | 0.63756581 |
| 131 | MP0003115_abnormal_respiratory_system | 0.63152935 |
| 132 | MP0000383_abnormal_hair_follicle | 0.62536828 |
| 133 | MP0008995_early_reproductive_senescence | 0.62373025 |
| 134 | MP0002938_white_spotting | 0.61970262 |
| 135 | MP0003861_abnormal_nervous_system | 0.60887384 |
| 136 | MP0002163_abnormal_gland_morphology | 0.58778398 |
| 137 | MP0002932_abnormal_joint_morphology | 0.57488080 |
| 138 | MP0003935_abnormal_craniofacial_develop | 0.57174692 |
| 139 | MP0003121_genomic_imprinting | 0.56346860 |
| 140 | MP0000733_abnormal_muscle_development | 0.55598583 |
| 141 | MP0008789_abnormal_olfactory_epithelium | 0.54293023 |
| 142 | MP0002161_abnormal_fertility/fecundity | 0.53822293 |
| 143 | MP0002114_abnormal_axial_skeleton | 0.53427066 |
| 144 | MP0002429_abnormal_blood_cell | 0.52178444 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Breast hypoplasia (HP:0003187) | 4.70527427 |
| 2 | Birth length less than 3rd percentile (HP:0003561) | 4.65317633 |
| 3 | Patellar aplasia (HP:0006443) | 4.07996408 |
| 4 | Carpal bone hypoplasia (HP:0001498) | 4.05615718 |
| 5 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.98228076 |
| 6 | Cerebral hypomyelination (HP:0006808) | 3.91481744 |
| 7 | Reticulocytopenia (HP:0001896) | 3.91044879 |
| 8 | Impulsivity (HP:0100710) | 3.75655277 |
| 9 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.67452511 |
| 10 | Hyperacusis (HP:0010780) | 3.66556297 |
| 11 | Rough bone trabeculation (HP:0100670) | 3.63648845 |
| 12 | Septate vagina (HP:0001153) | 3.60615732 |
| 13 | Chromsome breakage (HP:0040012) | 3.48044545 |
| 14 | Absent radius (HP:0003974) | 3.44826904 |
| 15 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.43318742 |
| 16 | Oral leukoplakia (HP:0002745) | 3.37895013 |
| 17 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.33215434 |
| 18 | Aplasia involving forearm bones (HP:0009822) | 3.32419191 |
| 19 | Absent forearm bone (HP:0003953) | 3.32419191 |
| 20 | Abnormal number of erythroid precursors (HP:0012131) | 3.20081705 |
| 21 | Abnormality of the preputium (HP:0100587) | 3.17141430 |
| 22 | Meckel diverticulum (HP:0002245) | 3.10962855 |
| 23 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 3.10389868 |
| 24 | Asymmetry of the thorax (HP:0001555) | 2.99791414 |
| 25 | Abnormality of the ileum (HP:0001549) | 2.93971508 |
| 26 | Macrocytic anemia (HP:0001972) | 2.82788370 |
| 27 | Ulnar bowing (HP:0003031) | 2.81493099 |
| 28 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.80989866 |
| 29 | Small intestinal stenosis (HP:0012848) | 2.76177565 |
| 30 | Duodenal stenosis (HP:0100867) | 2.76177565 |
| 31 | Abnormality of chromosome stability (HP:0003220) | 2.71968548 |
| 32 | Premature ovarian failure (HP:0008209) | 2.70503504 |
| 33 | Absent thumb (HP:0009777) | 2.65818593 |
| 34 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.62909195 |
| 35 | Ureteral duplication (HP:0000073) | 2.59586422 |
| 36 | Insomnia (HP:0100785) | 2.59561566 |
| 37 | Horseshoe kidney (HP:0000085) | 2.58864598 |
| 38 | Trismus (HP:0000211) | 2.58721261 |
| 39 | Multiple enchondromatosis (HP:0005701) | 2.56857166 |
| 40 | Secondary amenorrhea (HP:0000869) | 2.53534982 |
| 41 | Abnormal trabecular bone morphology (HP:0100671) | 2.52346906 |
| 42 | Oligodactyly (HP:0012165) | 2.50540393 |
| 43 | Entropion (HP:0000621) | 2.49248676 |
| 44 | Degeneration of anterior horn cells (HP:0002398) | 2.46771829 |
| 45 | Abnormality of the anterior horn cell (HP:0006802) | 2.46771829 |
| 46 | Selective tooth agenesis (HP:0001592) | 2.46518881 |
| 47 | Microvesicular hepatic steatosis (HP:0001414) | 2.45499332 |
| 48 | Progressive muscle weakness (HP:0003323) | 2.44197436 |
| 49 | Colon cancer (HP:0003003) | 2.43199915 |
| 50 | Abnormality of the umbilical cord (HP:0010881) | 2.42769228 |
| 51 | Bone marrow hypocellularity (HP:0005528) | 2.42183604 |
| 52 | Neoplasm of the pancreas (HP:0002894) | 2.41881161 |
| 53 | Absent epiphyses (HP:0010577) | 2.41239338 |
| 54 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.41239338 |
| 55 | Glossoptosis (HP:0000162) | 2.40138362 |
| 56 | Pili torti (HP:0003777) | 2.39190848 |
| 57 | Deviation of the thumb (HP:0009603) | 2.38109350 |
| 58 | Triphalangeal thumb (HP:0001199) | 2.37583924 |
| 59 | Testicular atrophy (HP:0000029) | 2.36457298 |
| 60 | Broad distal phalanx of finger (HP:0009836) | 2.36236996 |
| 61 | Elfin facies (HP:0004428) | 2.35114157 |
| 62 | Microretrognathia (HP:0000308) | 2.34663447 |
| 63 | Pallor (HP:0000980) | 2.33611072 |
| 64 | Medulloblastoma (HP:0002885) | 2.33060786 |
| 65 | Small epiphyses (HP:0010585) | 2.29360326 |
| 66 | Duplication of thumb phalanx (HP:0009942) | 2.28755514 |
| 67 | Myelodysplasia (HP:0002863) | 2.28500668 |
| 68 | Overriding aorta (HP:0002623) | 2.28380707 |
| 69 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 2.27270752 |
| 70 | Abnormality of the duodenum (HP:0002246) | 2.27051654 |
| 71 | High anterior hairline (HP:0009890) | 2.25684731 |
| 72 | Premature graying of hair (HP:0002216) | 2.25188716 |
| 73 | Atresia of the external auditory canal (HP:0000413) | 2.24218485 |
| 74 | Abnormality of the labia minora (HP:0012880) | 2.22959672 |
| 75 | Tracheoesophageal fistula (HP:0002575) | 2.21394334 |
| 76 | Short middle phalanx of the 5th finger (HP:0004220) | 2.17189818 |
| 77 | Hypoplasia of the radius (HP:0002984) | 2.16381173 |
| 78 | Sloping forehead (HP:0000340) | 2.14409849 |
| 79 | 11 pairs of ribs (HP:0000878) | 2.12954956 |
| 80 | Microglossia (HP:0000171) | 2.11576064 |
| 81 | Oligodactyly (hands) (HP:0001180) | 2.11416856 |
| 82 | Cellular immunodeficiency (HP:0005374) | 2.11195845 |
| 83 | Missing ribs (HP:0000921) | 2.10703521 |
| 84 | Abnormality of reticulocytes (HP:0004312) | 2.09632001 |
| 85 | Ependymoma (HP:0002888) | 2.08511733 |
| 86 | Progressive external ophthalmoplegia (HP:0000590) | 2.08101708 |
| 87 | Cleft eyelid (HP:0000625) | 2.06929325 |
| 88 | Irregular epiphyses (HP:0010582) | 2.06156012 |
| 89 | CNS hypomyelination (HP:0003429) | 2.03659848 |
| 90 | Patellar dislocation (HP:0002999) | 2.03400720 |
| 91 | Increased nuchal translucency (HP:0010880) | 2.03350761 |
| 92 | Short thumb (HP:0009778) | 2.02632494 |
| 93 | Abnormal lung lobation (HP:0002101) | 1.99968936 |
| 94 | Hyperglycinemia (HP:0002154) | 1.99648974 |
| 95 | Achilles tendon contracture (HP:0001771) | 1.99245490 |
| 96 | Ragged-red muscle fibers (HP:0003200) | 1.97155618 |
| 97 | Abnormal number of incisors (HP:0011064) | 1.96466110 |
| 98 | Sparse lateral eyebrow (HP:0005338) | 1.95643807 |
| 99 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.95540701 |
| 100 | Vaginal fistula (HP:0004320) | 1.94039398 |
| 101 | Personality changes (HP:0000751) | 1.93655570 |
| 102 | Ectopic kidney (HP:0000086) | 1.91282166 |
| 103 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.91202330 |
| 104 | Hypoparathyroidism (HP:0000829) | 1.90233310 |
| 105 | Renal duplication (HP:0000075) | 1.90062364 |
| 106 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.89904849 |
| 107 | Self-mutilation (HP:0000742) | 1.89099277 |
| 108 | Duplicated collecting system (HP:0000081) | 1.86784078 |
| 109 | Sparse eyelashes (HP:0000653) | 1.85996641 |
| 110 | Cafe-au-lait spot (HP:0000957) | 1.85827074 |
| 111 | Micronodular cirrhosis (HP:0001413) | 1.85741482 |
| 112 | Facial hemangioma (HP:0000329) | 1.84490850 |
| 113 | Rhabdomyosarcoma (HP:0002859) | 1.83967700 |
| 114 | Abnormality of the carotid arteries (HP:0005344) | 1.82910452 |
| 115 | Megaloblastic anemia (HP:0001889) | 1.81978770 |
| 116 | Squamous cell carcinoma (HP:0002860) | 1.81596026 |
| 117 | Prominent nose (HP:0000448) | 1.81371953 |
| 118 | Broad face (HP:0000283) | 1.80535948 |
| 119 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.80198633 |
| 120 | Concave nail (HP:0001598) | 1.79834625 |
| 121 | Aplastic anemia (HP:0001915) | 1.79381565 |
| 122 | Choanal atresia (HP:0000453) | 1.79184355 |
| 123 | Flat acetabular roof (HP:0003180) | 1.78963616 |
| 124 | Congenital, generalized hypertrichosis (HP:0004540) | 1.75954501 |
| 125 | Pustule (HP:0200039) | 1.73849764 |
| 126 | Abnormality of the Achilles tendon (HP:0005109) | 1.73580660 |
| 127 | Progressive hearing impairment (HP:0001730) | 1.72573031 |
| 128 | Truncus arteriosus (HP:0001660) | 1.72218919 |
| 129 | Long palpebral fissure (HP:0000637) | 1.71414411 |
| 130 | Ankyloglossia (HP:0010296) | 1.71101447 |
| 131 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.70507000 |
| 132 | Intestinal fistula (HP:0100819) | 1.70023664 |
| 133 | Short nail (HP:0001799) | 1.69584419 |
| 134 | Pelvic girdle muscle weakness (HP:0003749) | 1.69583722 |
| 135 | Partial duplication of thumb phalanx (HP:0009944) | 1.69165856 |
| 136 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.68805076 |
| 137 | Germ cell neoplasia (HP:0100728) | 1.68393298 |
| 138 | Supernumerary spleens (HP:0009799) | 1.68098581 |
| 139 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.67918478 |
| 140 | Poikiloderma (HP:0001029) | 1.66682185 |
| 141 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.66562959 |
| 142 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.66562959 |
| 143 | Single umbilical artery (HP:0001195) | 1.66562959 |
| 144 | Breast aplasia (HP:0100783) | 1.66375021 |
| 145 | Dysmetric saccades (HP:0000641) | 1.66207230 |
| 146 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.66042827 |
| 147 | Overlapping toe (HP:0001845) | 1.65603465 |
| 148 | Hyperthyroidism (HP:0000836) | 1.65342953 |
| 149 | Proximal placement of thumb (HP:0009623) | 1.65136417 |
| 150 | Abnormality of glycolysis (HP:0004366) | 1.64601099 |
| 151 | Spinal cord compression (HP:0002176) | 1.63511747 |
| 152 | Abnormal hair laboratory examination (HP:0003328) | 1.62094576 |
| 153 | Rectovaginal fistula (HP:0000143) | 1.61431852 |
| 154 | Rectal fistula (HP:0100590) | 1.61431852 |
| 155 | Abnormality of cochlea (HP:0000375) | 1.60805071 |
| 156 | Preauricular skin tag (HP:0000384) | 1.60381292 |
| 157 | Thin bony cortex (HP:0002753) | 1.60338688 |
| 158 | Abnormality of the gastric mucosa (HP:0004295) | 1.60062040 |
| 159 | Partial duplication of the phalanx of hand (HP:0009999) | 1.59931461 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 8.02576091 |
| 2 | WEE1 | 4.63636842 |
| 3 | NEK2 | 3.60238458 |
| 4 | SMG1 | 3.48520562 |
| 5 | SIK1 | 3.15540007 |
| 6 | BRSK1 | 2.81640726 |
| 7 | BRSK2 | 2.68342047 |
| 8 | PLK4 | 2.68123392 |
| 9 | TTK | 2.64012122 |
| 10 | MST1R | 2.61530278 |
| 11 | EIF2AK1 | 2.55689960 |
| 12 | STK16 | 2.43469998 |
| 13 | CDC7 | 2.42486662 |
| 14 | ICK | 2.31143638 |
| 15 | PLK1 | 2.25736342 |
| 16 | SRPK1 | 2.17186081 |
| 17 | TSSK6 | 2.12982299 |
| 18 | PKN2 | 2.09415007 |
| 19 | TLK1 | 2.03661429 |
| 20 | VRK2 | 1.85221870 |
| 21 | AURKB | 1.80723114 |
| 22 | DYRK3 | 1.79122989 |
| 23 | TESK2 | 1.76521231 |
| 24 | EPHA2 | 1.76098623 |
| 25 | AURKA | 1.75665192 |
| 26 | MKNK2 | 1.66082813 |
| 27 | CCNB1 | 1.65613994 |
| 28 | PLK3 | 1.63748407 |
| 29 | NME2 | 1.63685886 |
| 30 | NEK1 | 1.58844270 |
| 31 | MKNK1 | 1.52844401 |
| 32 | CHEK2 | 1.51903756 |
| 33 | IRAK2 | 1.44450095 |
| 34 | EIF2AK3 | 1.43403119 |
| 35 | ZAK | 1.41464846 |
| 36 | STK10 | 1.40749071 |
| 37 | MAP3K8 | 1.38235103 |
| 38 | CDK7 | 1.32758015 |
| 39 | CDK4 | 1.32351267 |
| 40 | VRK1 | 1.31681996 |
| 41 | AKT3 | 1.30874019 |
| 42 | ACVR1B | 1.29863862 |
| 43 | MELK | 1.27488726 |
| 44 | RPS6KA4 | 1.26758199 |
| 45 | ATR | 1.15307342 |
| 46 | MAP3K10 | 1.10908545 |
| 47 | CHEK1 | 1.09603151 |
| 48 | STK4 | 1.05680868 |
| 49 | MET | 1.02337125 |
| 50 | LMTK2 | 1.00743450 |
| 51 | BRAF | 0.98032918 |
| 52 | RPS6KB2 | 0.91456249 |
| 53 | ILK | 0.89539383 |
| 54 | PAK1 | 0.86499861 |
| 55 | PTK6 | 0.85974872 |
| 56 | FGFR4 | 0.82962264 |
| 57 | PRPF4B | 0.80523467 |
| 58 | PAK4 | 0.77544839 |
| 59 | EEF2K | 0.76749473 |
| 60 | CDK2 | 0.75864544 |
| 61 | PRKCI | 0.75290237 |
| 62 | TAF1 | 0.72792275 |
| 63 | PRKD3 | 0.72592311 |
| 64 | ARAF | 0.70282129 |
| 65 | PNCK | 0.68708301 |
| 66 | PTK2 | 0.67173154 |
| 67 | STK3 | 0.67138255 |
| 68 | CDK1 | 0.62065893 |
| 69 | EIF2AK2 | 0.61905297 |
| 70 | MAPK11 | 0.61052028 |
| 71 | AKT2 | 0.59070942 |
| 72 | UHMK1 | 0.58854367 |
| 73 | TESK1 | 0.58346548 |
| 74 | CAMK1D | 0.58111794 |
| 75 | IRAK3 | 0.57171712 |
| 76 | PIM1 | 0.56786930 |
| 77 | MARK3 | 0.56646614 |
| 78 | ATM | 0.55772654 |
| 79 | ALK | 0.55763707 |
| 80 | PASK | 0.53822326 |
| 81 | CDK8 | 0.53113816 |
| 82 | BMX | 0.52929372 |
| 83 | CSNK2A1 | 0.52668859 |
| 84 | TTN | 0.52091619 |
| 85 | MAP3K9 | 0.52087962 |
| 86 | CSNK2A2 | 0.51349679 |
| 87 | STK39 | 0.49701239 |
| 88 | MUSK | 0.49648479 |
| 89 | RPS6KA5 | 0.46720712 |
| 90 | IRAK4 | 0.46110704 |
| 91 | PIM2 | 0.44583691 |
| 92 | MAP4K1 | 0.43966779 |
| 93 | CDK12 | 0.41864092 |
| 94 | RIPK1 | 0.41107003 |
| 95 | DDR2 | 0.40085880 |
| 96 | TRIB3 | 0.38478118 |
| 97 | NME1 | 0.38471225 |
| 98 | MAP3K11 | 0.37615431 |
| 99 | ERBB4 | 0.37364727 |
| 100 | KDR | 0.36592087 |
| 101 | PDGFRA | 0.35921118 |
| 102 | CDK6 | 0.35101540 |
| 103 | WNK4 | 0.34280463 |
| 104 | PDPK1 | 0.33845521 |
| 105 | LATS2 | 0.32565428 |
| 106 | DMPK | 0.31664750 |
| 107 | TAOK1 | 0.30453688 |
| 108 | CSNK1E | 0.30174976 |
| 109 | NEK6 | 0.28826485 |
| 110 | CDK15 | 0.28818080 |
| 111 | RPS6KB1 | 0.28749987 |
| 112 | MTOR | 0.27561692 |
| 113 | MAP2K2 | 0.27225204 |
| 114 | DYRK2 | 0.26957149 |
| 115 | MAPKAPK2 | 0.26388205 |
| 116 | DYRK1B | 0.25626350 |
| 117 | RPS6KA1 | 0.22593537 |
| 118 | SCYL2 | 0.22349392 |
| 119 | PBK | 0.21889730 |
| 120 | CLK1 | 0.21646888 |
| 121 | LRRK2 | 0.21355192 |
| 122 | TAOK2 | 0.20333408 |
| 123 | GRK6 | 0.19546574 |
| 124 | CSNK1G3 | 0.18700770 |
| 125 | MAPKAPK3 | 0.18343677 |
| 126 | PDK4 | 0.18230553 |
| 127 | PDK3 | 0.18230553 |
| 128 | BRD4 | 0.17619999 |
| 129 | MAPK9 | 0.16631448 |
| 130 | PRKDC | 0.16507527 |
| 131 | BCKDK | 0.15536613 |
| 132 | CDK11A | 0.14903239 |
| 133 | BLK | 0.13427559 |
| 134 | CSNK1G1 | 0.13414890 |
| 135 | STK38L | 0.13083755 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.35911265 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.85473098 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.81440444 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 3.53180844 |
| 5 | Spliceosome_Homo sapiens_hsa03040 | 3.50122381 |
| 6 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 3.39131144 |
| 7 | RNA transport_Homo sapiens_hsa03013 | 3.31893997 |
| 8 | Proteasome_Homo sapiens_hsa03050 | 3.30225045 |
| 9 | Ribosome_Homo sapiens_hsa03010 | 3.26049781 |
| 10 | Cell cycle_Homo sapiens_hsa04110 | 3.22877648 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 3.17192509 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.85472115 |
| 13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.58736826 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.55189264 |
| 15 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.32914925 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.95689226 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.94520616 |
| 18 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.87149875 |
| 19 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.85922228 |
| 20 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.75962991 |
| 21 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.71457796 |
| 22 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.67847624 |
| 23 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.56305543 |
| 24 | RNA degradation_Homo sapiens_hsa03018 | 1.55192223 |
| 25 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.45547730 |
| 26 | Purine metabolism_Homo sapiens_hsa00230 | 1.45268017 |
| 27 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.42994449 |
| 28 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.26725485 |
| 29 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.26213890 |
| 30 | Sulfur relay system_Homo sapiens_hsa04122 | 1.21168180 |
| 31 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.20506086 |
| 32 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.15283742 |
| 33 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.05372012 |
| 34 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.03451648 |
| 35 | Endometrial cancer_Homo sapiens_hsa05213 | 1.03181921 |
| 36 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.96778327 |
| 37 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.96358561 |
| 38 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.96122834 |
| 39 | Lysine degradation_Homo sapiens_hsa00310 | 0.94947497 |
| 40 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.93959342 |
| 41 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.90255025 |
| 42 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.86359000 |
| 43 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.84655227 |
| 44 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.82733617 |
| 45 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.82069511 |
| 46 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.79892477 |
| 47 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.79124217 |
| 48 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.79058401 |
| 49 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.75510051 |
| 50 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.74068360 |
| 51 | HTLV-I infection_Homo sapiens_hsa05166 | 0.72776076 |
| 52 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.66643186 |
| 53 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.66094384 |
| 54 | Glioma_Homo sapiens_hsa05214 | 0.66078974 |
| 55 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.65163041 |
| 56 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.63725599 |
| 57 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.63137792 |
| 58 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.62817997 |
| 59 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.62774179 |
| 60 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.62758062 |
| 61 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.61292135 |
| 62 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.60267466 |
| 63 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.59096970 |
| 64 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.57470911 |
| 65 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.57150310 |
| 66 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.56159066 |
| 67 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.52438849 |
| 68 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.52408976 |
| 69 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.51392517 |
| 70 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.50074892 |
| 71 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.49902617 |
| 72 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.49723233 |
| 73 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.49588589 |
| 74 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.48818843 |
| 75 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.48142140 |
| 76 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.47226452 |
| 77 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.46365313 |
| 78 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.45091912 |
| 79 | Adherens junction_Homo sapiens_hsa04520 | 0.41892126 |
| 80 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.41560713 |
| 81 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.41351154 |
| 82 | Alcoholism_Homo sapiens_hsa05034 | 0.39417706 |
| 83 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.38808738 |
| 84 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.38622976 |
| 85 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.38003140 |
| 86 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.36457856 |
| 87 | Apoptosis_Homo sapiens_hsa04210 | 0.35996382 |
| 88 | Bladder cancer_Homo sapiens_hsa05219 | 0.35290480 |
| 89 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.34202891 |
| 90 | Thyroid cancer_Homo sapiens_hsa05216 | 0.34081644 |
| 91 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.33885862 |
| 92 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.33084443 |
| 93 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.31214367 |
| 94 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.30996281 |
| 95 | Carbon metabolism_Homo sapiens_hsa01200 | 0.29994477 |
| 96 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.29213014 |
| 97 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.27453253 |
| 98 | Colorectal cancer_Homo sapiens_hsa05210 | 0.26807859 |
| 99 | Huntingtons disease_Homo sapiens_hsa05016 | 0.25894430 |
| 100 | Hepatitis B_Homo sapiens_hsa05161 | 0.25779404 |
| 101 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.24499786 |
| 102 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.24353136 |
| 103 | Metabolic pathways_Homo sapiens_hsa01100 | 0.24229807 |
| 104 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.23913576 |
| 105 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.23446292 |
| 106 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.18331340 |
| 107 | Pathways in cancer_Homo sapiens_hsa05200 | 0.17100111 |
| 108 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.16945455 |
| 109 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.16373811 |
| 110 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.16340864 |
| 111 | Galactose metabolism_Homo sapiens_hsa00052 | 0.15574493 |
| 112 | Legionellosis_Homo sapiens_hsa05134 | 0.13642337 |
| 113 | Prostate cancer_Homo sapiens_hsa05215 | 0.13532086 |
| 114 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.13465692 |
| 115 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.11293864 |
| 116 | Protein export_Homo sapiens_hsa03060 | 0.11187123 |
| 117 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.11110630 |
| 118 | Tight junction_Homo sapiens_hsa04530 | 0.08417343 |
| 119 | Measles_Homo sapiens_hsa05162 | 0.08313791 |
| 120 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.07663425 |
| 121 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.06944880 |
| 122 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.06475617 |
| 123 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.05885872 |
| 124 | Circadian rhythm_Homo sapiens_hsa04710 | 0.05724670 |
| 125 | Influenza A_Homo sapiens_hsa05164 | 0.05199275 |
| 126 | Melanoma_Homo sapiens_hsa05218 | 0.04599973 |
| 127 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.04435888 |

