SARAF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.60951425
2Golgi transport vesicle coating (GO:0048200)3.91472504
3COPI coating of Golgi vesicle (GO:0048205)3.91472504
4nucleobase catabolic process (GO:0046113)3.72196327
5negative regulation of cell killing (GO:0031342)3.71855597
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.71855597
7activated T cell proliferation (GO:0050798)3.65642199
8sensory perception of smell (GO:0007608)3.54500379
9negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.35203100
10tolerance induction (GO:0002507)3.28419408
11gamma-aminobutyric acid transport (GO:0015812)3.26377285
12negative T cell selection (GO:0043383)3.19382381
13ionotropic glutamate receptor signaling pathway (GO:0035235)3.19323271
14positive regulation of mitochondrial fission (GO:0090141)3.18796379
15detection of calcium ion (GO:0005513)3.13149660
16negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.04638630
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04117971
18vocalization behavior (GO:0071625)3.03009763
19negative thymic T cell selection (GO:0045060)3.01406041
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01272847
21activation of protein kinase A activity (GO:0034199)2.96390673
22ER overload response (GO:0006983)2.93684954
23regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.92281202
24positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.92181550
25mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.92181550
26establishment of mitochondrion localization (GO:0051654)2.88434869
27synaptic vesicle maturation (GO:0016188)2.88363093
28negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87153075
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87034202
30regulation of amyloid precursor protein catabolic process (GO:1902991)2.87010859
31positive regulation of gamma-delta T cell activation (GO:0046645)2.84342427
32cilium or flagellum-dependent cell motility (GO:0001539)2.82088894
33protein maturation by protein folding (GO:0022417)2.81057376
34regulation of neurotransmitter levels (GO:0001505)2.80601982
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78403209
36regulation of beta-amyloid formation (GO:1902003)2.78026654
37synaptic transmission, glutamatergic (GO:0035249)2.76655835
38regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76417334
39cellular potassium ion homeostasis (GO:0030007)2.76174625
40retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.75683108
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.71961743
42glycosphingolipid biosynthetic process (GO:0006688)2.71432473
43regulation of synaptic vesicle exocytosis (GO:2000300)2.71404168
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.69879500
45negative regulation of immunoglobulin mediated immune response (GO:0002890)2.69288107
46negative regulation of B cell mediated immunity (GO:0002713)2.69288107
47toxin metabolic process (GO:0009404)2.68772659
48signal peptide processing (GO:0006465)2.68298999
49synaptic vesicle exocytosis (GO:0016079)2.68153421
50protein localization to synapse (GO:0035418)2.65939953
51neuron-neuron synaptic transmission (GO:0007270)2.62317075
52regulation of synaptic transmission, glutamatergic (GO:0051966)2.61511846
53ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.61321198
54postsynaptic membrane organization (GO:0001941)2.61033589
55neurotransmitter-gated ion channel clustering (GO:0072578)2.60286975
56protein retention in ER lumen (GO:0006621)2.58638620
57synapse assembly (GO:0007416)2.57535712
58cellular response to glucagon stimulus (GO:0071377)2.55431252
59regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.55138626
60neuromuscular process controlling posture (GO:0050884)2.54737184
61negative regulation of lymphocyte mediated immunity (GO:0002707)2.53962876
62axonemal dynein complex assembly (GO:0070286)2.53001864
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.50873051
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50207429
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.50207429
66potassium ion homeostasis (GO:0055075)2.48395595
67regulation of gamma-delta T cell differentiation (GO:0045586)2.47892343
68presynaptic membrane assembly (GO:0097105)2.47585975
69long-term synaptic potentiation (GO:0060291)2.46910002
70regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.46363633
71glutamate receptor signaling pathway (GO:0007215)2.45750576
72sodium ion export (GO:0071436)2.45145746
73positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.44982159
74regulation of synaptic vesicle transport (GO:1902803)2.44332945
75axoneme assembly (GO:0035082)2.42301574
76auditory behavior (GO:0031223)2.41401330
77calcium-mediated signaling using intracellular calcium source (GO:0035584)2.40802172
78cilium movement (GO:0003341)2.40571293
79neuronal ion channel clustering (GO:0045161)2.39808149
80presynaptic membrane organization (GO:0097090)2.39416786
81sensory perception of chemical stimulus (GO:0007606)2.39040374
82neuron cell-cell adhesion (GO:0007158)2.38861303
83synaptic vesicle docking involved in exocytosis (GO:0016081)2.38773615
84organelle transport along microtubule (GO:0072384)2.38475682
85sialylation (GO:0097503)2.37850445
86synaptic vesicle transport (GO:0048489)2.37796696
87establishment of synaptic vesicle localization (GO:0097480)2.37796696
88gamma-aminobutyric acid signaling pathway (GO:0007214)2.37064089
89creatine metabolic process (GO:0006600)2.36663737
90glutamate secretion (GO:0014047)2.35762948
91potassium ion import (GO:0010107)2.35617700
92regulation of voltage-gated calcium channel activity (GO:1901385)2.34512039
93peptide hormone processing (GO:0016486)2.34047473
94mating behavior (GO:0007617)2.33692644
95establishment of vesicle localization (GO:0051650)2.33593121
96positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.32898967
97positive T cell selection (GO:0043368)2.31949278
98regulation of feeding behavior (GO:0060259)2.30911533
99response to auditory stimulus (GO:0010996)2.30610894
100positive regulation of membrane potential (GO:0045838)2.30339151
101neurofilament cytoskeleton organization (GO:0060052)2.30250414
102epithelial cilium movement (GO:0003351)2.29848936
103response to dietary excess (GO:0002021)2.29073917
104positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.28742260
105acidic amino acid transport (GO:0015800)2.28523467
106cellular response to interleukin-15 (GO:0071350)2.28150394
107nucleoside diphosphate catabolic process (GO:0009134)2.27807746
108protein insertion into membrane (GO:0051205)2.27001627
109dopamine biosynthetic process (GO:0042416)2.26374433
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.26195049
111epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.26028928
112exploration behavior (GO:0035640)2.26026495
113dendritic spine morphogenesis (GO:0060997)2.25947439
114regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.25508465
115negative regulation of glycoprotein biosynthetic process (GO:0010561)2.24753772
116positive regulation of granulocyte differentiation (GO:0030854)2.24527200
117dendritic spine organization (GO:0097061)2.24455075
118central nervous system myelination (GO:0022010)2.24335351
119axon ensheathment in central nervous system (GO:0032291)2.24335351
120regulation of autophagic vacuole assembly (GO:2000785)2.24108300
121relaxation of cardiac muscle (GO:0055119)2.23623548
122neurotransmitter biosynthetic process (GO:0042136)2.23483326
123regulation of neurotransmitter secretion (GO:0046928)2.22486540
124regulation of gamma-delta T cell activation (GO:0046643)2.21637248
125T cell migration (GO:0072678)2.21392593
126succinate metabolic process (GO:0006105)2.21239357
127response to pheromone (GO:0019236)2.21219310
128response to interleukin-15 (GO:0070672)2.20921595
129cell communication by electrical coupling (GO:0010644)2.18760132
130regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.18208116
131regulation of interleukin-4 production (GO:0032673)2.17618150
132neuronal action potential propagation (GO:0019227)2.17145208
133regulation of synapse structural plasticity (GO:0051823)2.16546860
134cerebellar Purkinje cell layer development (GO:0021680)2.15545764
135vesicle coating (GO:0006901)2.13982620
136protein localization to cilium (GO:0061512)2.12481640
137negative regulation of inclusion body assembly (GO:0090084)2.11476468
138magnesium ion transport (GO:0015693)2.10995189
139activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.09850846
140insulin secretion (GO:0030073)2.09727084
141positive regulation of potassium ion transmembrane transport (GO:1901381)2.09499872
142positive regulation of potassium ion transport (GO:0043268)2.08179854
143protein targeting to Golgi (GO:0000042)2.06228696
144COPII vesicle coating (GO:0048208)2.05220632
145neurotransmitter secretion (GO:0007269)2.04438180
146positive regulation of insulin secretion (GO:0032024)2.03337782
147regulation of insulin secretion (GO:0050796)2.00792076
148locomotory exploration behavior (GO:0035641)2.00220609
149regulation of type B pancreatic cell apoptotic process (GO:2000674)1.99566763
150regulation of calcium ion-dependent exocytosis (GO:0017158)1.99340816
151regulation of vesicle fusion (GO:0031338)1.98997589
152positive regulation of exocytosis (GO:0045921)1.96940918
153neurotransmitter transport (GO:0006836)1.96127773
154regulation of ARF protein signal transduction (GO:0032012)1.95995023
155transmission of nerve impulse (GO:0019226)1.94915639
156membrane depolarization during cardiac muscle cell action potential (GO:0086012)1.94824238
157protein localization to Golgi apparatus (GO:0034067)1.93736444
158vesicle transport along microtubule (GO:0047496)1.93231045
159negative regulation of neurotransmitter transport (GO:0051589)1.93142128
160cellular copper ion homeostasis (GO:0006878)1.93118428
161adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)1.93069401
162nerve growth factor signaling pathway (GO:0038180)1.92237259
163macroautophagy (GO:0016236)1.91548683
164positive regulation of growth hormone secretion (GO:0060124)1.91022353
165negative regulation of glycoprotein metabolic process (GO:1903019)1.90997233
166response to glucagon (GO:0033762)1.90900498
167regulation of neuronal synaptic plasticity (GO:0048168)1.89749384
168membrane repolarization (GO:0086009)1.87785212
169regulation of isotype switching to IgG isotypes (GO:0048302)1.87269263
170regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.86942002
171positive regulation of nuclease activity (GO:0032075)1.86383743
172positive regulation of peptide secretion (GO:0002793)1.86059324
173endocrine pancreas development (GO:0031018)1.85954058
174layer formation in cerebral cortex (GO:0021819)1.85950176
175photoreceptor cell differentiation (GO:0046530)1.85876978
176eye photoreceptor cell differentiation (GO:0001754)1.85876978
177L-serine transport (GO:0015825)1.85461755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.28436662
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.65678738
3SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18099434
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12801866
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12020030
6MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06389939
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97189668
8POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96522664
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91923407
10JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86192760
11REST_21632747_ChIP-Seq_MESCs_Mouse1.84343981
12DROSHA_22980978_ChIP-Seq_HELA_Human1.81827839
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80027721
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79495597
15JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76737352
16SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76303002
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.75635753
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69926639
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69926639
20REST_18959480_ChIP-ChIP_MESCs_Mouse1.64073337
21GBX2_23144817_ChIP-Seq_PC3_Human1.62755167
22NR3C1_23031785_ChIP-Seq_PC12_Mouse1.61756014
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.58515816
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.50477689
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48449690
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.43723071
27GATA1_22025678_ChIP-Seq_K562_Human1.41060032
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39034130
29TAF15_26573619_Chip-Seq_HEK293_Human1.38714517
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.37206686
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.29048997
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.28534911
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28019260
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.27250180
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26639665
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25601911
37RNF2_27304074_Chip-Seq_NSC_Mouse1.25394144
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23989422
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21826300
40ZNF274_21170338_ChIP-Seq_K562_Hela1.17591256
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.16021075
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12067984
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11575280
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10872195
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10382910
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10282722
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09124874
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08349956
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08188045
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07186339
51RUNX_20019798_ChIP-Seq_JUKART_Human1.06992599
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05712069
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05100956
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04973238
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04915035
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03357713
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02734425
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.02463609
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01618751
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01548044
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01269892
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00143861
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99755162
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99307940
65GATA1_19941826_ChIP-Seq_K562_Human0.99291899
66ZNF263_19887448_ChIP-Seq_K562_Human0.98272182
67NANOG_18555785_Chip-Seq_ESCs_Mouse0.97014484
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96678665
69TAL1_26923725_Chip-Seq_HPCs_Mouse0.96411317
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96091175
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95562364
72SMAD4_21799915_ChIP-Seq_A2780_Human0.95546639
73KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95515302
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94576405
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94070198
76IRF8_21731497_ChIP-ChIP_J774_Mouse0.92830480
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92528056
78CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92308705
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91804615
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91032649
81MYB_26560356_Chip-Seq_TH2_Human0.90928790
82BCAT_22108803_ChIP-Seq_LS180_Human0.90323729
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90238433
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90200816
85AR_21572438_ChIP-Seq_LNCaP_Human0.90092362
86GATA3_27048872_Chip-Seq_THYMUS_Human0.89583692
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89539056
88STAT3_23295773_ChIP-Seq_U87_Human0.89432039
89WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89250707
90ER_23166858_ChIP-Seq_MCF-7_Human0.89221007
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88409027
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88068840
93P53_22387025_ChIP-Seq_ESCs_Mouse0.87965353
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.87559705
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87339044
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87197141
97ERG_21242973_ChIP-ChIP_JURKAT_Human0.86946992
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86371758
99CBP_20019798_ChIP-Seq_JUKART_Human0.85502074
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85502074
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84522107
102ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83955172
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83607214
104EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83576551
105IGF1R_20145208_ChIP-Seq_DFB_Human0.82992270
106CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82601272
107LXR_22158963_ChIP-Seq_LIVER_Mouse0.82535076
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82422941
109SOX2_21211035_ChIP-Seq_LN229_Gbm0.82252824
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82127198
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81892221
112LXR_22292898_ChIP-Seq_THP-1_Human0.81694610
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81675240
114TET1_21490601_ChIP-Seq_MESCs_Mouse0.81521222
115IRF8_27001747_Chip-Seq_BMDM_Mouse0.81177916
116RING1B_27294783_Chip-Seq_ESCs_Mouse0.80684046
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80077656
118TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80054467
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80004316
120OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79790622
121RUNX2_22187159_ChIP-Seq_PCA_Human0.79402252
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79267620
123ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79221733
124EP300_21415370_ChIP-Seq_HL-1_Mouse0.79019100
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.78976641
126PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78671016
127ZFP57_27257070_Chip-Seq_ESCs_Mouse0.77964000
128CLOCK_20551151_ChIP-Seq_293T_Human0.77799770
129FLI1_21867929_ChIP-Seq_TH2_Mouse0.77721662
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.77559260
131RXR_22158963_ChIP-Seq_LIVER_Mouse0.76490650
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76355805
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76355805
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76253871
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.75967319
136AR_25329375_ChIP-Seq_VCAP_Human0.75753734
137P300_19829295_ChIP-Seq_ESCs_Human0.75720188
138GATA2_21666600_ChIP-Seq_HMVEC_Human0.75429241
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.75181369
140CTCF_27219007_Chip-Seq_Bcells_Human0.75060196
141KDM2B_26808549_Chip-Seq_K562_Human0.74957850
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.74700287
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.73776673
144E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.72309494
145VDR_22108803_ChIP-Seq_LS180_Human0.72065258
146BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70743493
147FOXH1_21741376_ChIP-Seq_ESCs_Human0.69771926
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.69760669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction3.44134500
2MP0002909_abnormal_adrenal_gland3.00531701
3MP0004859_abnormal_synaptic_plasticity2.83514863
4MP0003329_amyloid_beta_deposits2.78931939
5MP0000013_abnormal_adipose_tissue2.40968786
6MP0005645_abnormal_hypothalamus_physiol2.40512281
7MP0003787_abnormal_imprinting2.38137283
8MP0003724_increased_susceptibility_to2.31855228
9MP0004270_analgesia2.31015423
10MP0002837_dystrophic_cardiac_calcinosis2.24916295
11MP0003635_abnormal_synaptic_transmissio2.23809040
12MP0005058_abnormal_lysosome_morphology2.07062971
13MP0003880_abnormal_central_pattern2.05672100
14MP0004043_abnormal_pH_regulation2.03211766
15MP0001501_abnormal_sleep_pattern1.94425155
16MP0009780_abnormal_chondrocyte_physiolo1.91324946
17MP0002064_seizures1.86363035
18MP0002272_abnormal_nervous_system1.85652999
19MP0003195_calcinosis1.83018784
20MP0002822_catalepsy1.82141143
21MP0002693_abnormal_pancreas_physiology1.73932573
22MP0000465_gastrointestinal_hemorrhage1.70648096
23MP0006276_abnormal_autonomic_nervous1.70240501
24MP0001502_abnormal_circadian_rhythm1.67817289
25MP0002653_abnormal_ependyma_morphology1.67199152
26MP0009745_abnormal_behavioral_response1.67080782
27MP0005671_abnormal_response_to1.66117631
28MP0004858_abnormal_nervous_system1.65817024
29MP0000604_amyloidosis1.65149776
30MP0003183_abnormal_peptide_metabolism1.64834654
31MP0005646_abnormal_pituitary_gland1.64748425
32MP0010386_abnormal_urinary_bladder1.64715333
33MP0005379_endocrine/exocrine_gland_phen1.60665830
34MP0002063_abnormal_learning/memory/cond1.59102904
35MP0001944_abnormal_pancreas_morphology1.58137331
36MP0005535_abnormal_body_temperature1.57942153
37MP0005423_abnormal_somatic_nervous1.55636426
38MP0002734_abnormal_mechanical_nocicepti1.53927506
39MP0003172_abnormal_lysosome_physiology1.50894611
40MP0002572_abnormal_emotion/affect_behav1.49010586
41MP0002102_abnormal_ear_morphology1.47961036
42MP0002735_abnormal_chemical_nociception1.46732716
43MP0002733_abnormal_thermal_nociception1.46167567
44MP0004510_myositis1.45872375
45MP0000920_abnormal_myelination1.45717817
46MP0003763_abnormal_thymus_physiology1.39162041
47MP0000778_abnormal_nervous_system1.38642289
48MP0001486_abnormal_startle_reflex1.35857036
49MP0001970_abnormal_pain_threshold1.35294275
50MP0001188_hyperpigmentation1.33427029
51MP0001905_abnormal_dopamine_level1.33317332
52MP0002877_abnormal_melanocyte_morpholog1.30799304
53MP0004130_abnormal_muscle_cell1.30240648
54MP0003633_abnormal_nervous_system1.29843178
55MP0002078_abnormal_glucose_homeostasis1.29234667
56MP0004811_abnormal_neuron_physiology1.28348725
57MP0003634_abnormal_glial_cell1.28211721
58MP0002736_abnormal_nociception_after1.27812219
59MP0001765_abnormal_ion_homeostasis1.26250670
60MP0008961_abnormal_basal_metabolism1.26005133
61MP0003690_abnormal_glial_cell1.25139528
62MP0003436_decreased_susceptibility_to1.24049129
63MP0008569_lethality_at_weaning1.20460209
64MP0002557_abnormal_social/conspecific_i1.19402399
65MP0002184_abnormal_innervation1.16253115
66MP0000747_muscle_weakness1.15472351
67MP0000003_abnormal_adipose_tissue1.15399623
68MP0001440_abnormal_grooming_behavior1.14885982
69MP0002229_neurodegeneration1.13997445
70MP0004036_abnormal_muscle_relaxation1.13613074
71MP0009046_muscle_twitch1.12969053
72MP0004145_abnormal_muscle_electrophysio1.11553610
73MP0002067_abnormal_sensory_capabilities1.11352344
74MP0001529_abnormal_vocalization1.08318466
75MP0000751_myopathy1.08285200
76MP0006082_CNS_inflammation1.08192516
77MP0001986_abnormal_taste_sensitivity1.07081118
78MP0005220_abnormal_exocrine_pancreas1.06959305
79MP0005394_taste/olfaction_phenotype1.06354694
80MP0005499_abnormal_olfactory_system1.06354694
81MP0002876_abnormal_thyroid_physiology1.06217524
82MP0003075_altered_response_to1.05493756
83MP0008260_abnormal_autophagy1.05374360
84MP0004885_abnormal_endolymph1.04876567
85MP0001968_abnormal_touch/_nociception1.04821485
86MP0005310_abnormal_salivary_gland1.04818327
87MP0004924_abnormal_behavior1.04304896
88MP0005386_behavior/neurological_phenoty1.04304896
89MP0009840_abnormal_foam_cell1.04008424
90MP0002638_abnormal_pupillary_reflex1.03439762
91MP0005000_abnormal_immune_tolerance1.02727414
92MP0008877_abnormal_DNA_methylation1.02635063
93MP0003300_gastrointestinal_ulcer1.01780083
94MP0003011_delayed_dark_adaptation0.99745733
95MP0000955_abnormal_spinal_cord0.99253510
96MP0001800_abnormal_humoral_immune0.98074715
97MP0003221_abnormal_cardiomyocyte_apopto0.97338081
98MP0005365_abnormal_bile_salt0.96267513
99MP0000230_abnormal_systemic_arterial0.96139286
100MP0001666_abnormal_nutrient_absorption0.95336650
101MP0002090_abnormal_vision0.95182499
102MP0004142_abnormal_muscle_tone0.94444563
103MP0003959_abnormal_lean_body0.94059327
104MP0003303_peritoneal_inflammation0.93098991
105MP0003632_abnormal_nervous_system0.92765934
106MP0003868_abnormal_feces_composition0.92041141
107MP0004742_abnormal_vestibular_system0.91981543
108MP0003283_abnormal_digestive_organ0.91810223
109MP0003121_genomic_imprinting0.91496468
110MP0002882_abnormal_neuron_morphology0.90676732
111MP0003953_abnormal_hormone_level0.88851714
112MP0006072_abnormal_retinal_apoptosis0.88460286
113MP0002118_abnormal_lipid_homeostasis0.87815391
114MP0008995_early_reproductive_senescence0.87277167
115MP0002723_abnormal_immune_serum0.87071291
116MP0005083_abnormal_biliary_tract0.87004138
117MP0002066_abnormal_motor_capabilities/c0.86828168
118MP0003866_abnormal_defecation0.86644166
119MP0002420_abnormal_adaptive_immunity0.85223781
120MP0005167_abnormal_blood-brain_barrier0.85156895
121MP0002139_abnormal_hepatobiliary_system0.84943645
122MP0003631_nervous_system_phenotype0.84199887
123MP0003122_maternal_imprinting0.83869545
124MP0001664_abnormal_digestion0.83529423
125MP0005025_abnormal_response_to0.83278261
126MP0001819_abnormal_immune_cell0.83243898
127MP0005551_abnormal_eye_electrophysiolog0.83127421
128MP0008874_decreased_physiological_sensi0.82733203
129MP0002419_abnormal_innate_immunity0.82577296
130MP0004085_abnormal_heartbeat0.82356854
131MP0001485_abnormal_pinna_reflex0.82231421
132MP0003879_abnormal_hair_cell0.82196968
133MP0005584_abnormal_enzyme/coenzyme_acti0.81713546
134MP0002928_abnormal_bile_duct0.81098245
135MP0009785_altered_susceptibility_to0.80522544
136MP0002069_abnormal_eating/drinking_beha0.79491618
137MP0005253_abnormal_eye_physiology0.79272440
138MP0005448_abnormal_energy_balance0.78686266
139MP0001177_atelectasis0.74400631
140MP0005387_immune_system_phenotype0.73050484
141MP0001790_abnormal_immune_system0.73050484
142MP0001835_abnormal_antigen_presentation0.71186099
143MP0002452_abnormal_antigen_presenting0.71074503
144MP0001963_abnormal_hearing_physiology0.70766537
145MP0002009_preneoplasia0.70209596
146MP0002332_abnormal_exercise_endurance0.69931315

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)4.22283876
2Neurofibrillary tangles (HP:0002185)4.02192747
3Amyotrophic lateral sclerosis (HP:0007354)3.83106251
4Visual hallucinations (HP:0002367)3.61677394
5Hypothermia (HP:0002045)3.60695057
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.58563462
7Pheochromocytoma (HP:0002666)3.50327491
8Retinal dysplasia (HP:0007973)3.37136763
9Supranuclear gaze palsy (HP:0000605)3.33558227
10Neuroendocrine neoplasm (HP:0100634)3.29686804
11Cerebral inclusion bodies (HP:0100314)3.25939133
12Febrile seizures (HP:0002373)3.25245927
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.23946486
14Ketoacidosis (HP:0001993)3.23565967
15Abnormal respiratory epithelium morphology (HP:0012253)3.18937845
16Abnormal respiratory motile cilium morphology (HP:0005938)3.18937845
17Dysostosis multiplex (HP:0000943)3.17894704
18Gait imbalance (HP:0002141)3.09050967
19Hyperinsulinemic hypoglycemia (HP:0000825)3.08272439
20Stomatitis (HP:0010280)3.04926804
21Agitation (HP:0000713)3.04277040
22Hypoglycemic seizures (HP:0002173)3.00637900
23Mutism (HP:0002300)2.97006929
24Abnormality of binocular vision (HP:0011514)2.95502929
25Diplopia (HP:0000651)2.95502929
26Peripheral hypomyelination (HP:0007182)2.91111647
27Abnormal ciliary motility (HP:0012262)2.90887913
28Abnormal respiratory motile cilium physiology (HP:0012261)2.88297010
29Progressive cerebellar ataxia (HP:0002073)2.83092728
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.74139736
31Absent/shortened dynein arms (HP:0200106)2.74139736
32Atonic seizures (HP:0010819)2.68955292
33Congenital primary aphakia (HP:0007707)2.68432653
34Hypoglycemic coma (HP:0001325)2.67121204
35Urinary urgency (HP:0000012)2.65714347
36Abnormality of aromatic amino acid family metabolism (HP:0004338)2.63898977
37Type II lissencephaly (HP:0007260)2.61857417
38Abnormality of the corticospinal tract (HP:0002492)2.60643378
39Nephrogenic diabetes insipidus (HP:0009806)2.59781942
40Medial flaring of the eyebrow (HP:0010747)2.58395594
41Hemiplegia (HP:0002301)2.57609926
42Urinary glycosaminoglycan excretion (HP:0003541)2.56025598
43Mucopolysacchariduria (HP:0008155)2.56025598
44Atrophy/Degeneration involving motor neurons (HP:0007373)2.53474962
45Progressive neurologic deterioration (HP:0002344)2.51809463
46Eczematoid dermatitis (HP:0000976)2.48522208
47Limb dystonia (HP:0002451)2.47765661
48Split foot (HP:0001839)2.43637094
49Focal motor seizures (HP:0011153)2.42536946
50Anxiety (HP:0000739)2.42202385
51Ketosis (HP:0001946)2.41734682
52Symptomatic seizures (HP:0011145)2.40378112
53Abnormality of calcium-phosphate metabolism (HP:0100530)2.39959481
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38449827
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38449827
56Abnormality of polysaccharide metabolism (HP:0011012)2.38449827
57Ankle clonus (HP:0011448)2.34230728
58Absent speech (HP:0001344)2.32981386
59Cerebral hemorrhage (HP:0001342)2.31683866
60Myokymia (HP:0002411)2.30327636
61Hemiparesis (HP:0001269)2.28804334
62T lymphocytopenia (HP:0005403)2.25506044
63Excessive salivation (HP:0003781)2.24959724
64Retinal atrophy (HP:0001105)2.24829988
65Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.21218438
66Absence seizures (HP:0002121)2.20255430
67Specific learning disability (HP:0001328)2.18739285
68Ulnar claw (HP:0001178)2.18080703
69Depression (HP:0000716)2.17567294
70Progressive inability to walk (HP:0002505)2.17114405
71Large for gestational age (HP:0001520)2.16076520
72Palpitations (HP:0001962)2.16033590
73Late onset (HP:0003584)2.15167946
74Exercise-induced myalgia (HP:0003738)2.15038054
75Drooling (HP:0002307)2.14291840
76Severe combined immunodeficiency (HP:0004430)2.12818627
77Increased cerebral lipofuscin (HP:0011813)2.11690719
78Elevated erythrocyte sedimentation rate (HP:0003565)2.11683376
79Delusions (HP:0000746)2.11210731
80Impaired vibration sensation in the lower limbs (HP:0002166)2.11073206
81Recurrent sinusitis (HP:0011108)2.11027267
82Vacuolated lymphocytes (HP:0001922)2.07831174
83Morphological abnormality of the pyramidal tract (HP:0002062)2.06666405
84Decreased circulating renin level (HP:0003351)2.06665449
85Abnormality of T cell number (HP:0011839)2.05966977
86Increased circulating renin level (HP:0000848)2.03232951
87Abnormal pupillary function (HP:0007686)2.03157273
88Bronchiectasis (HP:0002110)2.03121321
89Postural instability (HP:0002172)2.00531204
90Spastic tetraplegia (HP:0002510)2.00267548
91Abnormality of liposaccharide metabolism (HP:0010968)1.99970866
92Abnormality of glycosphingolipid metabolism (HP:0004343)1.99970866
93Abnormality of glycolipid metabolism (HP:0010969)1.99970866
94Megalencephaly (HP:0001355)1.98964314
95Dysdiadochokinesis (HP:0002075)1.97423243
96Poor suck (HP:0002033)1.97414134
97Psychosis (HP:0000709)1.97381580
98Increased neuronal autofluorescent lipopigment (HP:0002074)1.94372818
99Focal seizures (HP:0007359)1.93889284
100Generalized tonic-clonic seizures (HP:0002069)1.93083729
101Sleep apnea (HP:0010535)1.92066723
102Hyperparathyroidism (HP:0000843)1.91803785
103Dialeptic seizures (HP:0011146)1.91094502
104Abnormality of the lower motor neuron (HP:0002366)1.90153379
105Restlessness (HP:0000711)1.89007464
106Abnormality of the pancreatic islet cells (HP:0006476)1.88342869
107Abnormality of endocrine pancreas physiology (HP:0012093)1.88342869
108Papilledema (HP:0001085)1.88056372
109Myoglobinuria (HP:0002913)1.87776847
110Spastic gait (HP:0002064)1.85885957
111Abnormality of eosinophils (HP:0001879)1.85219368
112Hypercortisolism (HP:0001578)1.85219103
113Myositis (HP:0100614)1.84480024
114Sensorimotor neuropathy (HP:0007141)1.84361105
115Scanning speech (HP:0002168)1.83682827
116Rapidly progressive (HP:0003678)1.83676729
117Torticollis (HP:0000473)1.82870018
118Genital tract atresia (HP:0001827)1.82668094
119Genetic anticipation (HP:0003743)1.82545829
120Asymmetric septal hypertrophy (HP:0001670)1.82008698
121Dyskinesia (HP:0100660)1.81684431
122Urinary bladder sphincter dysfunction (HP:0002839)1.81498360
123Menstrual irregularities (HP:0000858)1.80694171
124Anosmia (HP:0000458)1.80475033
125EEG with generalized epileptiform discharges (HP:0011198)1.78839416
126Growth hormone excess (HP:0000845)1.78492431
127Truncal ataxia (HP:0002078)1.77825359
128Clonus (HP:0002169)1.77188770
129Retrobulbar optic neuritis (HP:0100654)1.76487387
130Optic neuritis (HP:0100653)1.76487387
131Oligomenorrhea (HP:0000876)1.76427807
132Vaginal atresia (HP:0000148)1.76204030
133Dysmetria (HP:0001310)1.74816018
134Degeneration of the lateral corticospinal tracts (HP:0002314)1.73620826
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73620826
136Stomach cancer (HP:0012126)1.73468813
137Rigidity (HP:0002063)1.73151049
138Intention tremor (HP:0002080)1.73150913
139Epileptiform EEG discharges (HP:0011182)1.72266351
140Prolonged QT interval (HP:0001657)1.72193700
141Diminished motivation (HP:0000745)1.72105934
142Abnormal neuron morphology (HP:0012757)1.71135663
143Abnormality of the motor neurons (HP:0002450)1.71135663
144Hypsarrhythmia (HP:0002521)1.71102551
145Apathy (HP:0000741)1.71083619
146Syncope (HP:0001279)1.70994042
147Hypokalemia (HP:0002900)1.69126175
148Abnormality of the nasal mucosa (HP:0000433)1.68892324
149Abnormal eating behavior (HP:0100738)1.68628835
150Hyperphosphatemia (HP:0002905)1.67917091
151Tachypnea (HP:0002789)1.67877570
152Abnormality of macular pigmentation (HP:0008002)1.67862555
153Abnormality of renin-angiotensin system (HP:0000847)1.67141659
154Abnormal mitochondria in muscle tissue (HP:0008316)1.65024894
155Hyperventilation (HP:0002883)1.64190852
156Rhinitis (HP:0012384)1.63484374
157Action tremor (HP:0002345)1.63305242
158Nasal polyposis (HP:0100582)1.63252497
159Abnormality of the intrinsic pathway (HP:0010989)1.60739029
160Insulin-resistant diabetes mellitus (HP:0000831)1.60545071
161Hypokalemic alkalosis (HP:0001949)1.59309848
162Epileptic encephalopathy (HP:0200134)1.58602919
163Failure to thrive in infancy (HP:0001531)1.58494583
164Lower limb muscle weakness (HP:0007340)1.58244128
165Neuronal loss in central nervous system (HP:0002529)1.58179649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR2.80803326
2PHKG12.58569960
3PHKG22.58569960
4MAPK152.47535206
5CAMKK22.21735707
6SIK32.17991568
7INSRR2.09221840
8NTRK12.03044289
9CASK2.01367499
10NTRK31.99662152
11BCKDK1.95087855
12MAP3K21.89226517
13ARAF1.88983753
14SIK21.78975825
15ERBB31.73197956
16TAOK31.65602449
17MAP4K21.63318528
18WNK41.62782627
19PAK31.62768575
20MAPKAPK51.58886664
21TRIM281.54890147
22ERN11.50877718
23TNIK1.47578180
24PRKD31.47037172
25STK391.46647777
26MAP3K91.41892005
27PRKCH1.38848913
28EPHB11.38497787
29TRIB31.36403242
30HIPK21.35572180
31NTRK21.31881363
32TXK1.31704961
33MAP3K131.31023092
34LMTK21.28564313
35KSR21.24750109
36MAP3K121.24455309
37GRK61.23624559
38DYRK1B1.21117844
39RIPK41.18116553
40FGFR41.17952617
41FLT31.17291175
42ITK1.16965490
43MAP3K11.14347568
44OXSR11.11440092
45CAMKK11.09470599
46CAMK2D1.09146866
47UHMK11.07915150
48IRAK11.07392259
49MAP3K111.06886539
50CDK191.06122804
51CSNK1G21.05443515
52TESK11.05285206
53CAMK2B1.05236765
54DYRK1A1.04800076
55MAP3K41.03037872
56MINK11.02287169
57RET1.01527942
58MUSK1.00965538
59ZAP700.94875444
60CSNK1G30.94570362
61CDK50.93331487
62EPHA30.92325082
63IRAK20.92319077
64SIK10.90377555
65MAP2K70.90345293
66TESK20.90067933
67CAMK2G0.89450911
68DYRK20.89350152
69EPHA40.88039650
70PAK60.87526005
71SYK0.85385048
72CAMK2A0.85153301
73MAP2K40.83952603
74SCYL20.83465498
75NLK0.82538597
76MARK10.80224712
77LCK0.78680798
78MAP3K50.78039586
79PASK0.74862598
80HCK0.74621219
81GRK50.74368017
82MARK20.74288683
83CSK0.72901911
84MAP3K60.72531285
85MAPKAPK30.71701093
86TGFBR20.71235736
87PINK10.69920216
88CSNK1G10.69536758
89JAK10.68437130
90GRK70.68419660
91JAK30.67375334
92PRKD20.66712896
93MAP4K10.66677060
94PRKCG0.66266448
95CDK140.64983254
96MAPK130.64653835
97PDK10.64350327
98FES0.64205660
99IKBKE0.63926453
100CAMK40.63629507
101PDPK10.62968703
102DAPK20.62444603
103CSNK1A1L0.62184030
104LYN0.61594713
105TBK10.61533603
106CAMK1G0.60592125
107SGK20.59382665
108RPS6KA40.59169604
109MOS0.59010342
110JAK20.58128392
111SGK4940.57597383
112SGK2230.57597383
113PRKCE0.57242479
114ADRBK20.56050038
115NEK60.55698718
116MYLK0.55519052
117KSR10.55212851
118BMPR20.55006335
119TYK20.53735018
120BTK0.53734111
121CAMK10.52351056
122STK380.50016458
123PLK20.49496304
124LIMK10.49407098
125PRKCQ0.48980147
126PRKD10.48913246
127TYRO30.48390897
128PKN20.47989592
129MAP3K70.47789488
130PRPF4B0.47441119
131MAPK70.46178979
132MAPK120.46025324
133TNK20.45983368
134WNK30.45621930
135STK110.42299575
136PRKCZ0.41903292
137FYN0.41754665
138MAP3K140.41660518
139CDK180.39646848
140EGFR0.38548489

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.67108754
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.60958918
3Protein export_Homo sapiens_hsa030602.39548503
4Insulin secretion_Homo sapiens_hsa049112.24194827
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.96944402
6Synaptic vesicle cycle_Homo sapiens_hsa047211.87595945
7Sulfur metabolism_Homo sapiens_hsa009201.83788259
8Vibrio cholerae infection_Homo sapiens_hsa051101.76264417
9Cocaine addiction_Homo sapiens_hsa050301.74499134
10GABAergic synapse_Homo sapiens_hsa047271.72805806
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49723284
12Amphetamine addiction_Homo sapiens_hsa050311.49412838
13Circadian entrainment_Homo sapiens_hsa047131.47960243
14Collecting duct acid secretion_Homo sapiens_hsa049661.46296946
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43721701
16Morphine addiction_Homo sapiens_hsa050321.42024694
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40527369
18Dopaminergic synapse_Homo sapiens_hsa047281.38195911
19Primary immunodeficiency_Homo sapiens_hsa053401.36497703
20Pancreatic secretion_Homo sapiens_hsa049721.35387197
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29625832
22Lysosome_Homo sapiens_hsa041421.26558923
23Taste transduction_Homo sapiens_hsa047421.25069694
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24926424
25Cholinergic synapse_Homo sapiens_hsa047251.22748044
26Serotonergic synapse_Homo sapiens_hsa047261.22088912
27Gastric acid secretion_Homo sapiens_hsa049711.19119869
28Salivary secretion_Homo sapiens_hsa049701.19054562
29Fatty acid elongation_Homo sapiens_hsa000621.18327525
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17708553
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16805719
32Glutamatergic synapse_Homo sapiens_hsa047241.15738212
33Oxidative phosphorylation_Homo sapiens_hsa001901.13693868
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12616710
35Nicotine addiction_Homo sapiens_hsa050331.12243643
36Phototransduction_Homo sapiens_hsa047441.11998345
37Long-term potentiation_Homo sapiens_hsa047201.11425034
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10255487
39Renin secretion_Homo sapiens_hsa049241.08911441
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07628806
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07584117
42Phagosome_Homo sapiens_hsa041451.02512550
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01786377
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00566802
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00556493
46Nitrogen metabolism_Homo sapiens_hsa009101.00266651
47Type II diabetes mellitus_Homo sapiens_hsa049300.96793088
48N-Glycan biosynthesis_Homo sapiens_hsa005100.96327366
49Other glycan degradation_Homo sapiens_hsa005110.96096163
50Alzheimers disease_Homo sapiens_hsa050100.95707759
51Thyroid hormone synthesis_Homo sapiens_hsa049180.95221074
52Parkinsons disease_Homo sapiens_hsa050120.95032118
53Butanoate metabolism_Homo sapiens_hsa006500.94167898
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93451318
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92284465
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89484978
57Propanoate metabolism_Homo sapiens_hsa006400.89011302
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86641096
59Fatty acid metabolism_Homo sapiens_hsa012120.84002334
60Chemokine signaling pathway_Homo sapiens_hsa040620.82528309
61Calcium signaling pathway_Homo sapiens_hsa040200.81135331
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81042546
63Cardiac muscle contraction_Homo sapiens_hsa042600.80733971
64cAMP signaling pathway_Homo sapiens_hsa040240.80420832
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.80211040
66Prion diseases_Homo sapiens_hsa050200.80107435
67Osteoclast differentiation_Homo sapiens_hsa043800.80103134
68Autoimmune thyroid disease_Homo sapiens_hsa053200.79638033
69Fatty acid degradation_Homo sapiens_hsa000710.79544966
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79248399
71Allograft rejection_Homo sapiens_hsa053300.76967722
72Graft-versus-host disease_Homo sapiens_hsa053320.75934088
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74515165
74Estrogen signaling pathway_Homo sapiens_hsa049150.74447912
75Type I diabetes mellitus_Homo sapiens_hsa049400.73916193
76Salmonella infection_Homo sapiens_hsa051320.70767305
77Glucagon signaling pathway_Homo sapiens_hsa049220.69458232
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.68610687
79Tuberculosis_Homo sapiens_hsa051520.68250558
80Oxytocin signaling pathway_Homo sapiens_hsa049210.68122552
81GnRH signaling pathway_Homo sapiens_hsa049120.67854554
82Histidine metabolism_Homo sapiens_hsa003400.66902990
83Ras signaling pathway_Homo sapiens_hsa040140.66725200
84Bile secretion_Homo sapiens_hsa049760.66127188
85ABC transporters_Homo sapiens_hsa020100.65432155
86Regulation of autophagy_Homo sapiens_hsa041400.65066571
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65041655
88Sphingolipid metabolism_Homo sapiens_hsa006000.64910096
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.64492799
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61462316
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61144021
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60457539
93Circadian rhythm_Homo sapiens_hsa047100.59866299
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.59251555
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58829970
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57615082
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57519203
98Shigellosis_Homo sapiens_hsa051310.57486816
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.57349446
100Pertussis_Homo sapiens_hsa051330.57242865
101Legionellosis_Homo sapiens_hsa051340.56868558
102Axon guidance_Homo sapiens_hsa043600.56737167
103Long-term depression_Homo sapiens_hsa047300.56727619
104Insulin resistance_Homo sapiens_hsa049310.55824532
105Viral myocarditis_Homo sapiens_hsa054160.55001589
106Ether lipid metabolism_Homo sapiens_hsa005650.54488036
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53632338
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52494706
109Dilated cardiomyopathy_Homo sapiens_hsa054140.52378960
110Gap junction_Homo sapiens_hsa045400.52355479
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52044490
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51693535
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51350175
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.49575144
115Hematopoietic cell lineage_Homo sapiens_hsa046400.48951405
116MAPK signaling pathway_Homo sapiens_hsa040100.47917699
117Tryptophan metabolism_Homo sapiens_hsa003800.47439916
118Rheumatoid arthritis_Homo sapiens_hsa053230.47436618
119Choline metabolism in cancer_Homo sapiens_hsa052310.46824812
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46755897
121Fatty acid biosynthesis_Homo sapiens_hsa000610.45294215
122T cell receptor signaling pathway_Homo sapiens_hsa046600.45118490
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43982165
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43183524
125Peroxisome_Homo sapiens_hsa041460.43086896
126Endocytosis_Homo sapiens_hsa041440.41873516
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41616367
128Insulin signaling pathway_Homo sapiens_hsa049100.41608039
129Glycerolipid metabolism_Homo sapiens_hsa005610.41480757
130Linoleic acid metabolism_Homo sapiens_hsa005910.41406018
131Pyruvate metabolism_Homo sapiens_hsa006200.41238550
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40504033
133Ovarian steroidogenesis_Homo sapiens_hsa049130.40472624
134Staphylococcus aureus infection_Homo sapiens_hsa051500.38266687
135beta-Alanine metabolism_Homo sapiens_hsa004100.37889808
136Antigen processing and presentation_Homo sapiens_hsa046120.37501924
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37448763
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.36674171
139Inositol phosphate metabolism_Homo sapiens_hsa005620.36456545
140Leishmaniasis_Homo sapiens_hsa051400.36119319

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