SARDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.00879142
2omega-hydroxylase P450 pathway (GO:0097267)7.80684613
3L-phenylalanine catabolic process (GO:0006559)7.58142765
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.58142765
5L-phenylalanine metabolic process (GO:0006558)7.26533903
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.26533903
7aromatic amino acid family catabolic process (GO:0009074)6.81996630
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.15320972
9indole-containing compound catabolic process (GO:0042436)6.14360284
10indolalkylamine catabolic process (GO:0046218)6.14360284
11tryptophan catabolic process (GO:0006569)6.14360284
12kynurenine metabolic process (GO:0070189)5.99458981
13glyoxylate metabolic process (GO:0046487)5.89756375
14bile acid biosynthetic process (GO:0006699)5.85544986
15tryptophan metabolic process (GO:0006568)5.79341534
16regulation of plasminogen activation (GO:0010755)5.64926862
17urea metabolic process (GO:0019627)5.59844566
18urea cycle (GO:0000050)5.59844566
19cysteine metabolic process (GO:0006534)5.56474251
20alpha-linolenic acid metabolic process (GO:0036109)5.53940144
21drug metabolic process (GO:0017144)5.52978759
22negative regulation of fibrinolysis (GO:0051918)5.46821117
23sulfur amino acid catabolic process (GO:0000098)5.42656367
24oxidative demethylation (GO:0070989)5.42643461
25high-density lipoprotein particle remodeling (GO:0034375)5.39227259
26peptidyl-glutamic acid carboxylation (GO:0017187)5.24638899
27protein carboxylation (GO:0018214)5.24638899
28regulation of fibrinolysis (GO:0051917)5.23843380
29nitrogen cycle metabolic process (GO:0071941)5.15492527
30complement activation, alternative pathway (GO:0006957)5.12457768
31regulation of protein activation cascade (GO:2000257)5.10219243
32bile acid metabolic process (GO:0008206)5.00182591
33homocysteine metabolic process (GO:0050667)4.99014008
34aromatic amino acid family metabolic process (GO:0009072)4.97104236
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.92318231
36ethanol metabolic process (GO:0006067)4.91117589
37lysine catabolic process (GO:0006554)4.90161480
38lysine metabolic process (GO:0006553)4.90161480
39* serine family amino acid catabolic process (GO:0009071)4.89609774
40intestinal cholesterol absorption (GO:0030299)4.84188818
41tyrosine metabolic process (GO:0006570)4.79060803
42regulation of complement activation (GO:0030449)4.76602969
43phenylpropanoid metabolic process (GO:0009698)4.74835544
44reverse cholesterol transport (GO:0043691)4.73215903
45amino-acid betaine metabolic process (GO:0006577)4.71327400
46regulation of cholesterol esterification (GO:0010872)4.70454364
47regulation of triglyceride catabolic process (GO:0010896)4.66428062
48* alpha-amino acid catabolic process (GO:1901606)4.66389557
49protein-lipid complex remodeling (GO:0034368)4.63530642
50macromolecular complex remodeling (GO:0034367)4.63530642
51plasma lipoprotein particle remodeling (GO:0034369)4.63530642
52negative regulation of blood coagulation (GO:0030195)4.53361216
53negative regulation of hemostasis (GO:1900047)4.53361216
54cellular ketone body metabolic process (GO:0046950)4.51907217
55S-adenosylmethionine metabolic process (GO:0046500)4.51727009
56triglyceride homeostasis (GO:0070328)4.49625928
57acylglycerol homeostasis (GO:0055090)4.49625928
58regulation of humoral immune response (GO:0002920)4.48835395
59negative regulation of cholesterol transport (GO:0032375)4.48489961
60negative regulation of sterol transport (GO:0032372)4.48489961
61acute-phase response (GO:0006953)4.47101500
62negative regulation of protein activation cascade (GO:2000258)4.44850787
63phospholipid efflux (GO:0033700)4.38954086
64coenzyme catabolic process (GO:0009109)4.37004294
65indolalkylamine metabolic process (GO:0006586)4.34757605
66glutamate metabolic process (GO:0006536)4.32895189
67* cellular amino acid catabolic process (GO:0009063)4.32746066
68plasma lipoprotein particle clearance (GO:0034381)4.30063359
69bile acid and bile salt transport (GO:0015721)4.28806396
70cellular modified amino acid catabolic process (GO:0042219)4.26959277
71cellular biogenic amine catabolic process (GO:0042402)4.25416208
72amine catabolic process (GO:0009310)4.25416208
73cellular glucuronidation (GO:0052695)4.22925606
74imidazole-containing compound metabolic process (GO:0052803)4.22635176
75cytolysis (GO:0019835)4.17376908
76serine family amino acid biosynthetic process (GO:0009070)4.15735026
77* serine family amino acid metabolic process (GO:0009069)4.13842929
78benzene-containing compound metabolic process (GO:0042537)4.12472906
79opsonization (GO:0008228)4.12213104
80negative regulation of coagulation (GO:0050819)4.11442517
81* glycine metabolic process (GO:0006544)4.11118909
82drug catabolic process (GO:0042737)4.09407355
83ethanol oxidation (GO:0006069)4.08836091
84plasma lipoprotein particle organization (GO:0071827)4.06058469
85positive regulation of hemostasis (GO:1900048)4.05807879
86positive regulation of blood coagulation (GO:0030194)4.05807879
87cholesterol efflux (GO:0033344)4.05258369
88dicarboxylic acid biosynthetic process (GO:0043650)4.05173790
89negative regulation of wound healing (GO:0061045)4.01410315
90arginine metabolic process (GO:0006525)4.00029385
91aldehyde catabolic process (GO:0046185)3.93997994
92ketone body metabolic process (GO:1902224)3.92907879
93low-density lipoprotein particle remodeling (GO:0034374)3.91286052
94fibrinolysis (GO:0042730)3.90939987
95positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.90241610
96plasma lipoprotein particle assembly (GO:0034377)3.87023653
97short-chain fatty acid metabolic process (GO:0046459)3.86805831
98positive regulation of fatty acid biosynthetic process (GO:0045723)3.85219824
99* carboxylic acid catabolic process (GO:0046395)3.79619468
100* organic acid catabolic process (GO:0016054)3.79619468
101disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.79163025
102killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.79163025
103uronic acid metabolic process (GO:0006063)3.77516048
104glucuronate metabolic process (GO:0019585)3.77516048
105protein-lipid complex subunit organization (GO:0071825)3.75490750
106acetyl-CoA metabolic process (GO:0006084)3.75289524
107cofactor catabolic process (GO:0051187)3.72313907
108regulation of bile acid biosynthetic process (GO:0070857)3.71619318
109alkaloid metabolic process (GO:0009820)3.70969249
110regulation of cholesterol homeostasis (GO:2000188)3.69577505
111positive regulation of coagulation (GO:0050820)3.68780497
112phospholipid homeostasis (GO:0055091)3.68754182
113cholesterol homeostasis (GO:0042632)3.68545278
114regulation of apoptotic cell clearance (GO:2000425)3.67593912
115blood coagulation, intrinsic pathway (GO:0007597)3.67547177
116aspartate family amino acid catabolic process (GO:0009068)3.67212724
117positive regulation of lipid catabolic process (GO:0050996)3.66764276
118positive regulation of triglyceride lipase activity (GO:0061365)3.66762966
119positive regulation of lipoprotein lipase activity (GO:0051006)3.66762966
120urate metabolic process (GO:0046415)3.65437888
121negative regulation of complement activation (GO:0045916)3.64440813
122drug transmembrane transport (GO:0006855)3.63878915
123sterol homeostasis (GO:0055092)3.63260330
124negative regulation of lipase activity (GO:0060192)3.61905269
125exogenous drug catabolic process (GO:0042738)3.60082362
126very-low-density lipoprotein particle assembly (GO:0034379)3.59996436
127complement activation, classical pathway (GO:0006958)3.57555336
1282-oxoglutarate metabolic process (GO:0006103)3.57325591
129complement activation (GO:0006956)3.55800939
130protein activation cascade (GO:0072376)3.54395326
131peptidyl-glutamic acid modification (GO:0018200)3.38520811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.35177254
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.17737499
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.77213772
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.47176303
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.13003292
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.01349790
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.95694034
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.01503655
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.88678433
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10445047
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10228277
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8758487
13* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98963178
14CLOCK_20551151_ChIP-Seq_293T_Human1.69320198
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68892940
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.64223651
17HTT_18923047_ChIP-ChIP_STHdh_Human1.44871341
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42857487
19GATA1_22025678_ChIP-Seq_K562_Human1.33195365
20IRF1_19129219_ChIP-ChIP_H3396_Human1.32852459
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28570737
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26799439
23ZNF274_21170338_ChIP-Seq_K562_Hela1.21900319
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21603750
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21505346
26RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17806683
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15088257
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.05281667
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04738832
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04161274
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03457264
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02885528
33IGF1R_20145208_ChIP-Seq_DFB_Human1.02774734
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00382769
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97858531
36SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97854276
37ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96911214
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96328413
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95819850
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94733507
41RAC3_21632823_ChIP-Seq_H3396_Human0.91408670
42MYC_19829295_ChIP-Seq_ESCs_Human0.90290508
43GBX2_23144817_ChIP-Seq_PC3_Human0.89798676
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89034145
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88568068
46EZH2_27294783_Chip-Seq_NPCs_Mouse0.88444094
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87789491
48EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87087214
49GATA4_25053715_ChIP-Seq_YYC3_Human0.86653121
50POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84625832
51AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82850710
52SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81822464
53ESR2_21235772_ChIP-Seq_MCF-7_Human0.81130030
54SOX2_21211035_ChIP-Seq_LN229_Human0.80777201
55FOXH1_21741376_ChIP-Seq_EPCs_Human0.80620824
56ZNF263_19887448_ChIP-Seq_K562_Human0.80282207
57SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79250779
58NCOR_22424771_ChIP-Seq_293T_Human0.78884608
59FLI1_27457419_Chip-Seq_LIVER_Mouse0.78583227
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78549511
61ERA_21632823_ChIP-Seq_H3396_Human0.77945629
62FOXA1_25329375_ChIP-Seq_VCAP_Human0.77213204
63FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77213204
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77146229
65IRF8_22096565_ChIP-ChIP_GC-B_Human0.77080726
66PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76687436
67OCT4_20526341_ChIP-Seq_ESCs_Human0.76524393
68CRX_20693478_ChIP-Seq_RETINA_Mouse0.75594325
69RARA_24833708_ChIP-Seq_LIVER_Mouse0.72524019
70VDR_22108803_ChIP-Seq_LS180_Human0.71635757
71KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71593879
72AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71185910
73E2F1_20622854_ChIP-Seq_HELA_Human0.70805756
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70378156
75* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70195390
76NANOG_19829295_ChIP-Seq_ESCs_Human0.69897069
77SOX2_19829295_ChIP-Seq_ESCs_Human0.69897069
78SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69608831
79* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.69052921
80NANOG_20526341_ChIP-Seq_ESCs_Human0.68815456
81FOXH1_21741376_ChIP-Seq_ESCs_Human0.67979572
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.67707214
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67585590
84ER_23166858_ChIP-Seq_MCF-7_Human0.67434730
85NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66813924
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66813924
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66527728
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65396062
89SMAD1_18555785_Chip-Seq_ESCs_Mouse0.64786175
90RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63887993
91CDX2_22108803_ChIP-Seq_LS180_Human0.63803428
92P300_27268052_Chip-Seq_Bcells_Human0.63538968
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.63433833
94LXR_22292898_ChIP-Seq_THP-1_Human0.63128646
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.63062128
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.63035717
97ESR1_21235772_ChIP-Seq_MCF-7_Human0.62476599
98BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62064403
99RARB_24833708_ChIP-Seq_LIVER_Mouse0.61362900
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.61341461
101OCT4_21477851_ChIP-Seq_ESCs_Mouse0.60528184
102NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.60248739
103* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.60050468
104SPI1_20517297_ChIP-Seq_HL60_Human0.59534759
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.58730283
106CEBPB_22108803_ChIP-Seq_LS180_Human0.58259972
107ELF1_20517297_ChIP-Seq_JURKAT_Human0.58165226
108* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.57430663
109* SRF_21415370_ChIP-Seq_HL-1_Mouse0.57280515
110NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.56462826
111EGR1_19032775_ChIP-ChIP_M12_Human0.56445498
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56255619
113FOXA1_25552417_ChIP-Seq_VCAP_Human0.53882384
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53724535
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51742734
116CDX2_20551321_ChIP-Seq_CACO-2_Human0.51639926
117AR_20517297_ChIP-Seq_VCAP_Human0.51496406
118* MYC_19915707_ChIP-ChIP_AK7_Human0.50855027
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.50824191
120ESET_19884257_ChIP-Seq_ESCs_Mouse0.49573095
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.49279183
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.49004479
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48767049
124CBP_21632823_ChIP-Seq_H3396_Human0.48649602
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.47231338
126* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46650222
127P53_21459846_ChIP-Seq_SAOS-2_Human0.46528524
128GATA1_19941826_ChIP-Seq_K562_Human0.45381417
129GATA6_25053715_ChIP-Seq_YYC3_Human0.44958697
130TAF2_19829295_ChIP-Seq_ESCs_Human0.43934042
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.43760857
132* STAT1_17558387_ChIP-Seq_HELA_Human0.43714993
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.43540023
134* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.43416632
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43166012
136GATA2_19941826_ChIP-Seq_K562_Human0.42827118
137* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42285989
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42094795
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.41013994
140STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40241746
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.38622547
142MYC_27129775_Chip-Seq_CORNEA_Mouse0.38307312
143BCAT_22108803_ChIP-Seq_LS180_Human0.37871161
144ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.37730937
145GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.36731259
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.36517873
147SOX2_20726797_ChIP-Seq_SW620_Human0.35794099
148CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35662295
149GATA3_24758297_ChIP-Seq_MCF-7_Human0.35472358
150LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34931573
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.34790973
152P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.34565251
153* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.34563526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.24059217
2MP0005360_urolithiasis7.65074129
3MP0005085_abnormal_gallbladder_physiolo6.32577014
4MP0005365_abnormal_bile_salt6.14735905
5MP0008875_abnormal_xenobiotic_pharmacok5.08257600
6MP0003806_abnormal_nucleotide_metabolis4.08427764
7MP0003252_abnormal_bile_duct3.89003686
8MP0010329_abnormal_lipoprotein_level3.52215786
9MP0009840_abnormal_foam_cell3.17043603
10MP0005083_abnormal_biliary_tract3.12858919
11MP0005332_abnormal_amino_acid2.95072909
12MP0003195_calcinosis2.91523315
13MP0001666_abnormal_nutrient_absorption2.65763802
14MP0004019_abnormal_vitamin_homeostasis2.30153087
15MP0003191_abnormal_cellular_cholesterol2.26457015
16MP0000609_abnormal_liver_physiology2.12502694
17MP0002118_abnormal_lipid_homeostasis2.09722152
18MP0002138_abnormal_hepatobiliary_system2.04032123
19MP0003868_abnormal_feces_composition1.90948690
20MP0005319_abnormal_enzyme/_coenzyme1.84015466
21MP0001764_abnormal_homeostasis1.65202142
22MP0005584_abnormal_enzyme/coenzyme_acti1.58556923
23MP0005451_abnormal_body_composition1.49256782
24MP0009697_abnormal_copulation1.44466421
25MP0009643_abnormal_urine_homeostasis1.39368695
26MP0003011_delayed_dark_adaptation1.31832432
27MP0003186_abnormal_redox_activity1.31271881
28MP0003705_abnormal_hypodermis_morpholog1.30363864
29MP0003656_abnormal_erythrocyte_physiolo1.20605078
30MP0003122_maternal_imprinting1.20419467
31MP0002132_abnormal_respiratory_system1.20136421
32MP0000598_abnormal_liver_morphology1.17230761
33MP0005647_abnormal_sex_gland1.10068529
34MP0006292_abnormal_olfactory_placode1.09513305
35MP0000604_amyloidosis1.04453499
36MP0005636_abnormal_mineral_homeostasis1.03273347
37MP0009764_decreased_sensitivity_to1.02463749
38MP0002254_reproductive_system_inflammat0.99909489
39MP0009763_increased_sensitivity_to0.97052915
40MP0010368_abnormal_lymphatic_system0.90869081
41MP0005670_abnormal_white_adipose0.89269466
42MP0003172_abnormal_lysosome_physiology0.87910557
43MP0005408_hypopigmentation0.87091146
44MP0009642_abnormal_blood_homeostasis0.87070580
45MP0005084_abnormal_gallbladder_morpholo0.86324956
46MP0008469_abnormal_protein_level0.85687499
47MP0002282_abnormal_trachea_morphology0.85245507
48MP0006036_abnormal_mitochondrial_physio0.84111282
49MP0005220_abnormal_exocrine_pancreas0.82572454
50MP0002876_abnormal_thyroid_physiology0.79422787
51MP0002078_abnormal_glucose_homeostasis0.78426226
52MP0005376_homeostasis/metabolism_phenot0.76930417
53MP0001915_intracranial_hemorrhage0.76616948
54MP0005379_endocrine/exocrine_gland_phen0.76574767
55MP0009765_abnormal_xenobiotic_induced0.75218054
56MP0001756_abnormal_urination0.74575359
57MP0004130_abnormal_muscle_cell0.73085080
58MP0002971_abnormal_brown_adipose0.72665936
59MP0001661_extended_life_span0.71940251
60MP0005535_abnormal_body_temperature0.69666605
61MP0005334_abnormal_fat_pad0.68170149
62MP0003879_abnormal_hair_cell0.67252933
63MP0003690_abnormal_glial_cell0.66553221
64MP0005551_abnormal_eye_electrophysiolog0.65924494
65MP0000566_synostosis0.65422077
66MP0003329_amyloid_beta_deposits0.65367328
67MP0009053_abnormal_anal_canal0.64058284
68MP0005266_abnormal_metabolism0.60326982
69MP0005646_abnormal_pituitary_gland0.59366766
70MP0002136_abnormal_kidney_physiology0.57356916
71MP0000639_abnormal_adrenal_gland0.55917540
72MP0005448_abnormal_energy_balance0.55483688
73MP0006035_abnormal_mitochondrial_morpho0.54901658
74MP0005377_hearing/vestibular/ear_phenot0.53631259
75MP0003878_abnormal_ear_physiology0.53631259
76MP0002249_abnormal_larynx_morphology0.53328540
77MP0005395_other_phenotype0.50588829
78MP0002089_abnormal_postnatal_growth/wei0.50124206
79MP0002928_abnormal_bile_duct0.50113869
80MP0003638_abnormal_response/metabolism_0.49575210
81MP0001944_abnormal_pancreas_morphology0.46958323
82MP0005666_abnormal_adipose_tissue0.46680251
83MP0005464_abnormal_platelet_physiology0.45476935
84MP0008874_decreased_physiological_sensi0.43010571
85MP0002837_dystrophic_cardiac_calcinosis0.42540829
86MP0003718_maternal_effect0.42351823
87MP0003953_abnormal_hormone_level0.41990237
88MP0005187_abnormal_penis_morphology0.41531462
89MP0004043_abnormal_pH_regulation0.41377493
90MP0008873_increased_physiological_sensi0.40399182
91MP0002822_catalepsy0.40113534
92MP0003075_altered_response_to0.39978242
93MP0004782_abnormal_surfactant_physiolog0.39582346
94MP0004133_heterotaxia0.39167261
95MP0002090_abnormal_vision0.38880980
96MP0009672_abnormal_birth_weight0.38629965
97MP0002168_other_aberrant_phenotype0.38398816
98MP0009384_cardiac_valve_regurgitation0.38254263
99MP0003724_increased_susceptibility_to0.37747640
100MP0005248_abnormal_Harderian_gland0.37517657
101MP0000230_abnormal_systemic_arterial0.36867746
102MP0002796_impaired_skin_barrier0.35816568
103MP0008872_abnormal_physiological_respon0.35595648
104MP0005166_decreased_susceptibility_to0.34593583
105MP0005410_abnormal_fertilization0.34482115
106MP0009115_abnormal_fat_cell0.34160140
107MP0005058_abnormal_lysosome_morphology0.33909973
108MP0003436_decreased_susceptibility_to0.33875554
109MP0003123_paternal_imprinting0.32460639
110MP0001765_abnormal_ion_homeostasis0.31578452
111MP0001243_abnormal_dermal_layer0.31520729
112MP0001324_abnormal_eye_pigmentation0.31502008
113MP0001986_abnormal_taste_sensitivity0.31395109
114MP0003943_abnormal_hepatobiliary_system0.30880999
115MP0002970_abnormal_white_adipose0.30740783
116MP0000579_abnormal_nail_morphology0.30630022
117MP0002909_abnormal_adrenal_gland0.30502916
118MP0000249_abnormal_blood_vessel0.30466072
119MP0004142_abnormal_muscle_tone0.30424066
120MP0003699_abnormal_female_reproductive0.29439157
121MP0004381_abnormal_hair_follicle0.29382968
122MP0002163_abnormal_gland_morphology0.28982063
123MP0004883_abnormal_blood_vessel0.28749970
124MP0002135_abnormal_kidney_morphology0.27188903
125MP0001881_abnormal_mammary_gland0.26869080
126MP0002060_abnormal_skin_morphology0.26692088
127MP0001853_heart_inflammation0.25621100
128MP0001845_abnormal_inflammatory_respons0.25359875
129MP0003646_muscle_fatigue0.25153246
130MP0001984_abnormal_olfaction0.24047556

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.33428139
2Deep venous thrombosis (HP:0002625)7.22727548
3Intrahepatic cholestasis (HP:0001406)7.08627112
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.53635647
5Prolonged partial thromboplastin time (HP:0003645)6.26404163
6Xanthomatosis (HP:0000991)6.23348045
7Hypobetalipoproteinemia (HP:0003563)6.15432633
8Hyperlipoproteinemia (HP:0010980)5.40612620
9Complement deficiency (HP:0004431)5.08409211
10Hyperammonemia (HP:0001987)4.68931062
11Hypolipoproteinemia (HP:0010981)4.65439221
12Joint hemorrhage (HP:0005261)4.64377850
13Hyperglycinemia (HP:0002154)4.58686310
14Ketosis (HP:0001946)4.42708582
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.41452111
16Epidermoid cyst (HP:0200040)4.38980306
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.31923821
18Abnormality of the common coagulation pathway (HP:0010990)4.28902984
19Hyperglycinuria (HP:0003108)4.26192833
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.25245972
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22091828
22Abnormality of methionine metabolism (HP:0010901)4.21682534
23Abnormality of glycine metabolism (HP:0010895)4.18797189
24Abnormality of serine family amino acid metabolism (HP:0010894)4.18797189
25Hypoalphalipoproteinemia (HP:0003233)4.10959305
26Fat malabsorption (HP:0002630)4.04689253
27Hypoglycemic coma (HP:0001325)3.83738092
28Abnormality of pyrimidine metabolism (HP:0004353)3.76911346
29Abnormality of complement system (HP:0005339)3.69401272
30Abnormality of the intrinsic pathway (HP:0010989)3.67380577
31Conjugated hyperbilirubinemia (HP:0002908)3.57116216
32Hypercholesterolemia (HP:0003124)3.50785917
33Abnormality of fatty-acid metabolism (HP:0004359)3.46250820
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35290933
35Hyperbilirubinemia (HP:0002904)3.27801838
36Nephritis (HP:0000123)3.27642052
37Delayed CNS myelination (HP:0002188)3.22060871
38Abnormality of nucleobase metabolism (HP:0010932)3.21894956
39Ketoacidosis (HP:0001993)3.21751261
40Abnormality of serum amino acid levels (HP:0003112)3.13724252
41Steatorrhea (HP:0002570)3.04818795
42Hepatocellular carcinoma (HP:0001402)3.01539527
43Gout (HP:0001997)2.95931705
44Abnormality of purine metabolism (HP:0004352)2.94386761
45Myocardial infarction (HP:0001658)2.91213929
46Metabolic acidosis (HP:0001942)2.84821177
47Hypochromic microcytic anemia (HP:0004840)2.79768450
48Spontaneous abortion (HP:0005268)2.79262915
49Skin nodule (HP:0200036)2.74075752
50Vascular calcification (HP:0004934)2.71566763
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69379948
52Dicarboxylic aciduria (HP:0003215)2.69379948
53Lethargy (HP:0001254)2.67542258
54Fair hair (HP:0002286)2.65833237
55Systemic lupus erythematosus (HP:0002725)2.61140499
56Spastic diplegia (HP:0001264)2.51636500
57Purpura (HP:0000979)2.48991361
58Acanthocytosis (HP:0001927)2.45727778
59Cardiovascular calcification (HP:0011915)2.43488670
60Cerebral edema (HP:0002181)2.42836246
61Hypoglycemic seizures (HP:0002173)2.40445989
62Mitral stenosis (HP:0001718)2.40280856
63Irritability (HP:0000737)2.39906002
64Neonatal onset (HP:0003623)2.38888478
65Abnormal gallbladder morphology (HP:0012437)2.38441985
66Osteomalacia (HP:0002749)2.35874980
67Glomerulonephritis (HP:0000099)2.35288746
68Cholelithiasis (HP:0001081)2.33372977
69Malnutrition (HP:0004395)2.32834326
70Bile duct proliferation (HP:0001408)2.32816948
71Abnormal biliary tract physiology (HP:0012439)2.32816948
72Arthropathy (HP:0003040)2.32262053
73Pulmonary embolism (HP:0002204)2.27073158
74Generalized aminoaciduria (HP:0002909)2.26332462
75Cholecystitis (HP:0001082)2.25967058
76Abnormal gallbladder physiology (HP:0012438)2.25967058
77Amyloidosis (HP:0011034)2.20840767
78Enlarged kidneys (HP:0000105)2.20681624
79Esophageal varix (HP:0002040)2.19778848
80Pancreatitis (HP:0001733)2.18839064
81Sensorimotor neuropathy (HP:0007141)2.16865850
82Vomiting (HP:0002013)2.16585556
83Late onset (HP:0003584)2.14594421
84Alkalosis (HP:0001948)2.12253951
85Brushfield spots (HP:0001088)2.09909405
86Recurrent gram-negative bacterial infections (HP:0005420)2.09441727
87Menorrhagia (HP:0000132)2.09346571
88Abnormality of proline metabolism (HP:0010907)2.09252728
89Hydroxyprolinuria (HP:0003080)2.09252728
90Rickets (HP:0002748)2.04774203
91Opisthotonus (HP:0002179)2.03219644
92Gingival bleeding (HP:0000225)2.01925949
93Thrombophlebitis (HP:0004418)2.01784056
94Hyperphosphaturia (HP:0003109)2.01617407
95Hyperuricemia (HP:0002149)2.01541530
96Increased purine levels (HP:0004368)2.01541530
97Proximal tubulopathy (HP:0000114)1.99672617
98Hemorrhage of the eye (HP:0011885)1.97828369
99Abnormality of the gallbladder (HP:0005264)1.95479331
100Abnormal cartilage morphology (HP:0002763)1.95162144
101Neonatal hypoglycemia (HP:0001998)1.95152207
102Hyperinsulinemic hypoglycemia (HP:0000825)1.93565472
103Abnormal enzyme/coenzyme activity (HP:0012379)1.90473043
104Poikilocytosis (HP:0004447)1.90220605
105Hypophosphatemic rickets (HP:0004912)1.89912017
106Reduced antithrombin III activity (HP:0001976)1.84508817
107Retinal atrophy (HP:0001105)1.82402712
108Abnormality of transition element cation homeostasis (HP:0011030)1.81486705
109Abnormality of urine glucose concentration (HP:0011016)1.80436600
110Glycosuria (HP:0003076)1.80436600
111Abnormality of iron homeostasis (HP:0011031)1.80085759
112Renal cortical cysts (HP:0000803)1.79951933
113Abnormality of alanine metabolism (HP:0010916)1.75960001
114Hyperalaninemia (HP:0003348)1.75960001
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75960001
116Hypothermia (HP:0002045)1.74197441
117Generalized hypopigmentation of hair (HP:0011358)1.70105026
118Abnormality of vitamin metabolism (HP:0100508)1.66789566
119Joint swelling (HP:0001386)1.64989479
120Neoplasm of the liver (HP:0002896)1.61927721
121Potter facies (HP:0002009)1.61900705
122Facial shape deformation (HP:0011334)1.61900705
123Abnormal urine phosphate concentration (HP:0012599)1.59477296
124Increased serum pyruvate (HP:0003542)1.56213687
125Bifid scrotum (HP:0000048)1.55041306
126Hyperglycemia (HP:0003074)1.54803761
127Increased serum ferritin (HP:0003281)1.54446843
128Epistaxis (HP:0000421)1.54257319
129Cerebral palsy (HP:0100021)1.53286722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.37804256
2SIK14.59539544
3FGFR44.43475555
4ERN14.37251287
5INSRR2.84228300
6TAOK32.71651877
7ERBB42.63091737
8PKN22.52664351
9NLK2.45998773
10MAP4K22.45234937
11MUSK2.29156690
12MST1R2.23285593
13TRIB32.20295112
14MAP2K42.17228239
15CAMKK22.01731937
16NUAK11.90573493
17FLT31.86480202
18MAPK111.80927575
19LATS11.76761429
20PIK3CA1.74300951
21MAPKAPK31.69219650
22PIK3CG1.66646930
23PTK61.51179379
24TYK21.49887730
25ABL21.41479950
26DAPK21.41342922
27FRK1.41140027
28FGFR21.35169238
29NEK91.33287535
30ZAK1.29626207
31ACVR1B1.29517473
32CAMKK11.25080393
33KDR1.24198081
34MAP3K41.21981037
35MAP3K71.21872174
36TXK1.19842457
37PINK11.18507734
38SIK21.17846087
39STK38L1.16570724
40JAK21.14237636
41PRKAA21.13632146
42BMPR1B1.12995947
43CASK1.08332743
44ADRBK21.05864402
45MAP2K31.05686457
46NTRK31.05375026
47GRK61.04612945
48TNK21.04477715
49TYRO31.02582337
50TLK11.00762553
51VRK10.97315295
52ERBB20.95194582
53MAP3K100.94887087
54MET0.94727361
55JAK10.93354200
56TBK10.91967057
57MAPK130.91610234
58PRKCZ0.90886297
59EPHB10.89107999
60MAPK40.88563982
61MAP3K30.86889153
62TIE10.85173795
63BRD40.84792991
64FGFR10.84263247
65MAPK120.80276487
66NTRK20.78994857
67CAMK1D0.78271036
68EEF2K0.77916324
69DYRK1B0.77697008
70PRKG10.77401608
71CDK80.76868797
72CSNK1D0.76596803
73STK160.76056579
74CDK60.75679924
75MAP3K140.75482956
76RIPK10.75055548
77BCR0.74793641
78CDK70.74243678
79GSK3A0.73388116
80DYRK20.72371688
81PRKACG0.72269461
82MAP3K110.71512653
83EPHA30.70615976
84SGK30.70481200
85PRKAA10.70452457
86PRKACA0.69957939
87MAPK150.68554220
88VRK20.68066969
89TGFBR20.67528500
90PTK20.65780809
91BRSK20.64642329
92TNIK0.64065773
93WNK40.63165314
94BRSK10.62962424
95CSK0.62786807
96PDK20.62775279
97CAMK2G0.60483801
98MAP2K60.60273906
99PDPK10.55425380
100FGFR30.55390087
101PDK40.53701406
102PDK30.53701406
103IRAK30.53631107
104SGK20.52635840
105ITK0.52119021
106MAPK70.51733517
107SGK2230.51413793
108SGK4940.51413793
109WNK30.49267105
110CSF1R0.48719416
111RET0.46599430
112MAP2K70.46274478
113LCK0.45673707
114MAP2K10.45489310
115CSNK1G10.44675055
116PRKCQ0.44073894
117CSNK2A10.43991461
118TAOK20.43315149
119IGF1R0.42916467
120MAP4K10.42131423
121MTOR0.41829318
122EPHA40.41437022
123SGK10.40990294
124PLK30.40775867
125PRKCB0.40635661
126CSNK2A20.39934020
127CSNK1A10.39721881
128PASK0.39093711
129ICK0.38782814
130IKBKE0.38450924
131CSNK1E0.37965217
132MAP3K50.37462180
133AKT30.37403128
134CDK40.37093954
135LIMK10.37002032
136LATS20.36846037
137PRKCE0.36135935
138HIPK20.36055871
139PRKCG0.35629668
140GRK10.34582887
141PDK10.33886934
142BMX0.33375231
143CAMK1G0.31222913
144PDGFRA0.30776048
145CAMK40.29408381
146MAP2K20.29164185
147IRAK20.29097743
148EGFR0.29097241
149MAP3K60.28301468
150OXSR10.27765172
151PKN10.27007486
152MAP3K130.26939369
153PAK30.26880146
154IRAK10.25771841
155PRKCA0.23919364

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.37255380
2Nitrogen metabolism_Homo sapiens_hsa009103.61267387
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.38829684
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35453341
5Arginine biosynthesis_Homo sapiens_hsa002203.05103996
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70016075
7Tryptophan metabolism_Homo sapiens_hsa003802.68523419
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66699636
9Complement and coagulation cascades_Homo sapiens_hsa046102.62535788
10Fatty acid degradation_Homo sapiens_hsa000712.53017236
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47920803
12* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47229545
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29467420
14Butanoate metabolism_Homo sapiens_hsa006502.23748746
15Peroxisome_Homo sapiens_hsa041462.09270999
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08067806
17Propanoate metabolism_Homo sapiens_hsa006402.03616685
18Chemical carcinogenesis_Homo sapiens_hsa052041.89233997
19Histidine metabolism_Homo sapiens_hsa003401.87260090
20PPAR signaling pathway_Homo sapiens_hsa033201.87147043
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86968684
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.86542431
23Fatty acid metabolism_Homo sapiens_hsa012121.84350407
24beta-Alanine metabolism_Homo sapiens_hsa004101.75284785
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75041873
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.71720543
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69590193
28Caffeine metabolism_Homo sapiens_hsa002321.66739616
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64791419
30Staphylococcus aureus infection_Homo sapiens_hsa051501.64567568
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64451517
32Retinol metabolism_Homo sapiens_hsa008301.63746461
33Selenocompound metabolism_Homo sapiens_hsa004501.57813818
34Phenylalanine metabolism_Homo sapiens_hsa003601.53800242
35Bile secretion_Homo sapiens_hsa049761.51316840
36Pyruvate metabolism_Homo sapiens_hsa006201.43275693
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42014428
38Tyrosine metabolism_Homo sapiens_hsa003501.39602489
39Sulfur metabolism_Homo sapiens_hsa009201.38566919
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.31302012
41Fatty acid elongation_Homo sapiens_hsa000621.29785175
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28987275
43Biosynthesis of amino acids_Homo sapiens_hsa012301.24078205
44Folate biosynthesis_Homo sapiens_hsa007901.22129842
45Steroid biosynthesis_Homo sapiens_hsa001001.18449228
46Carbon metabolism_Homo sapiens_hsa012001.17895299
47Fat digestion and absorption_Homo sapiens_hsa049751.16804426
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.15649857
49ABC transporters_Homo sapiens_hsa020101.14888304
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07013264
51Arginine and proline metabolism_Homo sapiens_hsa003301.01939585
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00544917
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.97582947
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94201926
55Sulfur relay system_Homo sapiens_hsa041220.93578175
56Vitamin digestion and absorption_Homo sapiens_hsa049770.93547738
57Vitamin B6 metabolism_Homo sapiens_hsa007500.92217462
58Lysine degradation_Homo sapiens_hsa003100.85037589
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82269650
60One carbon pool by folate_Homo sapiens_hsa006700.73958462
61Glycerolipid metabolism_Homo sapiens_hsa005610.73316658
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73145688
63Glutathione metabolism_Homo sapiens_hsa004800.68296492
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60990702
65Pentose phosphate pathway_Homo sapiens_hsa000300.57715671
66Fatty acid biosynthesis_Homo sapiens_hsa000610.54317547
67* Metabolic pathways_Homo sapiens_hsa011000.45961070
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31058892
69Prion diseases_Homo sapiens_hsa050200.29541867
70Fructose and mannose metabolism_Homo sapiens_hsa000510.27119071
71Galactose metabolism_Homo sapiens_hsa000520.25755641
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25063299
73Insulin resistance_Homo sapiens_hsa049310.24616292
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.23590641
75Other glycan degradation_Homo sapiens_hsa005110.21527388
76Pertussis_Homo sapiens_hsa051330.21348536
77Linoleic acid metabolism_Homo sapiens_hsa005910.19640466
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18473310
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15539552
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.14387309
81Glucagon signaling pathway_Homo sapiens_hsa049220.10005652
82Ether lipid metabolism_Homo sapiens_hsa005650.04794917
83AMPK signaling pathway_Homo sapiens_hsa041520.04152003
84Bladder cancer_Homo sapiens_hsa05219-0.2271939
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2217861
86Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2199704
87Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1952052
88Pyrimidine metabolism_Homo sapiens_hsa00240-0.1887507
89African trypanosomiasis_Homo sapiens_hsa05143-0.1861524
90Hepatitis C_Homo sapiens_hsa05160-0.1816495
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1783118
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.1768349
93Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.1739153
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1738768
95Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1731769
96Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1607379
97Protein digestion and absorption_Homo sapiens_hsa04974-0.1583610
98Regulation of autophagy_Homo sapiens_hsa04140-0.1489286
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1444794
100Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1394438
101Renin-angiotensin system_Homo sapiens_hsa04614-0.1216035
102Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1106102
103Circadian rhythm_Homo sapiens_hsa04710-0.1017597
104Protein export_Homo sapiens_hsa03060-0.0908290
105Insulin signaling pathway_Homo sapiens_hsa04910-0.0892314
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0840151
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0775908
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0739071
109Sphingolipid metabolism_Homo sapiens_hsa00600-0.0524362
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0428212
111Serotonergic synapse_Homo sapiens_hsa04726-0.0266051
112N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0253075
113Mineral absorption_Homo sapiens_hsa04978-0.0227878

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