SARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)5.25538936
2L-serine metabolic process (GO:0006563)4.99070336
3peptidyl-arginine omega-N-methylation (GO:0035247)4.26622292
4protoporphyrinogen IX metabolic process (GO:0046501)4.21643162
5regulation of translational fidelity (GO:0006450)4.09576399
6peptidyl-arginine methylation (GO:0018216)3.95390530
7peptidyl-arginine N-methylation (GO:0035246)3.95390530
8ATP hydrolysis coupled proton transport (GO:0015991)3.93009698
9energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.93009698
10transferrin transport (GO:0033572)3.69267623
11negative regulation of microtubule polymerization (GO:0031115)3.69127447
12cerebellar Purkinje cell layer development (GO:0021680)3.63821301
13formation of translation preinitiation complex (GO:0001731)3.57815363
14histone arginine methylation (GO:0034969)3.57039653
15proteasome assembly (GO:0043248)3.56272226
16ribosome assembly (GO:0042255)3.50510215
17serine family amino acid biosynthetic process (GO:0009070)3.49080611
18protein neddylation (GO:0045116)3.45873535
19cell migration in hindbrain (GO:0021535)3.43974051
20ferric iron transport (GO:0015682)3.43637460
21trivalent inorganic cation transport (GO:0072512)3.43637460
22* tRNA aminoacylation for protein translation (GO:0006418)3.42577143
23Golgi transport vesicle coating (GO:0048200)3.40469088
24COPI coating of Golgi vesicle (GO:0048205)3.40469088
25synaptic vesicle exocytosis (GO:0016079)3.39674577
26retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.39352458
27regulation of short-term neuronal synaptic plasticity (GO:0048172)3.35271920
28neuron cell-cell adhesion (GO:0007158)3.35027667
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.34481024
30COPII vesicle coating (GO:0048208)3.31261255
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.30988564
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30875487
33* tRNA aminoacylation (GO:0043039)3.27868649
34* amino acid activation (GO:0043038)3.27868649
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24881039
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18931123
37sequestering of extracellular ligand from receptor (GO:0035581)3.17500795
38regulation of cellular amino acid metabolic process (GO:0006521)3.17426481
39establishment of integrated proviral latency (GO:0075713)3.15307281
40negative regulation of ligase activity (GO:0051352)3.13170564
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13170564
42ribosomal large subunit biogenesis (GO:0042273)3.12158133
43positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08984468
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08456984
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07097056
46vesicle coating (GO:0006901)3.06451414
47ribosome biogenesis (GO:0042254)3.04750827
48regulation of synaptic vesicle exocytosis (GO:2000300)3.04473032
49signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04291917
50intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04291917
51mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.01536352
52protein-cofactor linkage (GO:0018065)3.01479069
53signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00753891
54signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00753891
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00753891
56signal transduction involved in cell cycle checkpoint (GO:0072395)2.97863860
57signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96787620
58signal transduction involved in DNA damage checkpoint (GO:0072422)2.96787620
59cullin deneddylation (GO:0010388)2.93958687
60energy coupled proton transport, down electrochemical gradient (GO:0015985)2.91380598
61ATP synthesis coupled proton transport (GO:0015986)2.91380598
62positive regulation of ligase activity (GO:0051351)2.90842270
63establishment of viral latency (GO:0019043)2.87938356
64spliceosomal tri-snRNP complex assembly (GO:0000244)2.84823753
65regulation of ubiquitin-protein transferase activity (GO:0051438)2.83979003
66ribosomal small subunit biogenesis (GO:0042274)2.83179030
67protein maturation by protein folding (GO:0022417)2.79956519
68tetrahydrofolate metabolic process (GO:0046653)2.79760056
69positive regulation of synapse maturation (GO:0090129)2.79503162
70aspartate family amino acid biosynthetic process (GO:0009067)2.78805675
71folic acid-containing compound biosynthetic process (GO:0009396)2.78195179
72ribonucleoprotein complex disassembly (GO:0032988)2.78139801
73pteridine-containing compound biosynthetic process (GO:0042559)2.78092472
74regulation of mitochondrial translation (GO:0070129)2.77737724
75protein targeting to mitochondrion (GO:0006626)2.77436571
76proline transport (GO:0015824)2.76978053
77nucleobase-containing small molecule interconversion (GO:0015949)2.76235401
78neuron recognition (GO:0008038)2.75043904
79* tRNA metabolic process (GO:0006399)2.74674958
80ribonucleoprotein complex biogenesis (GO:0022613)2.74535753
81glutamate secretion (GO:0014047)2.72067015
82neuronal action potential propagation (GO:0019227)2.71970648
83NADH metabolic process (GO:0006734)2.71638131
84ER overload response (GO:0006983)2.70604945
85regulation of ligase activity (GO:0051340)2.69718137
86vocalization behavior (GO:0071625)2.65708120
87maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.65156015
88negative regulation of protein oligomerization (GO:0032460)2.64338682
89negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.64282975
90negative regulation of cell killing (GO:0031342)2.64282975
91axonal fasciculation (GO:0007413)2.64163469
92neurotransmitter secretion (GO:0007269)2.64088505
93regulation of translational elongation (GO:0006448)2.63897427
94glutamine metabolic process (GO:0006541)2.62194118
95nuclear envelope reassembly (GO:0031468)2.60144646
96mitotic nuclear envelope reassembly (GO:0007084)2.60144646
97establishment of protein localization to mitochondrion (GO:0072655)2.59953211
98organelle transport along microtubule (GO:0072384)2.58649719
99regulation of translational termination (GO:0006449)2.58202027
100protein localization to mitochondrion (GO:0070585)2.58184994
101L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57866406
102positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.57349582
1037-methylguanosine mRNA capping (GO:0006370)2.56544586
104negative regulation of appetite (GO:0032099)2.55650786
105negative regulation of response to food (GO:0032096)2.55650786
106activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.54302000
107establishment of protein localization to mitochondrial membrane (GO:0090151)2.53134905
108oxaloacetate metabolic process (GO:0006107)2.53081986
109regulation of mitotic spindle organization (GO:0060236)2.52589122
110layer formation in cerebral cortex (GO:0021819)2.52156685
111de novo protein folding (GO:0006458)2.49716266
112regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.48524779
113intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.48292417
114de novo posttranslational protein folding (GO:0051084)2.48096956
115ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.47655474
1167-methylguanosine RNA capping (GO:0009452)2.46841706
117RNA capping (GO:0036260)2.46841706
118positive regulation of nuclease activity (GO:0032075)2.46401897
119tricarboxylic acid cycle (GO:0006099)2.46366875
120mitotic sister chromatid segregation (GO:0000070)2.45773970
121cellular component biogenesis (GO:0044085)2.44270769
122gamma-aminobutyric acid signaling pathway (GO:0007214)2.44014708
123L-serine transport (GO:0015825)2.43643870
124negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.42379966
125GDP-mannose metabolic process (GO:0019673)2.41752639
126mitochondrial DNA metabolic process (GO:0032042)2.40710662
127peptidyl-proline hydroxylation (GO:0019511)2.40530721
128cellular protein complex disassembly (GO:0043624)2.40432570
129spliceosomal snRNP assembly (GO:0000387)2.39864896
130positive regulation of synapse assembly (GO:0051965)2.39540482
131homocysteine metabolic process (GO:0050667)2.39116920
132* translation (GO:0006412)2.38496054
133synaptic vesicle maturation (GO:0016188)2.38301031
134ER to Golgi vesicle-mediated transport (GO:0006888)2.37103868
135proline biosynthetic process (GO:0006561)2.36737677
136maturation of SSU-rRNA (GO:0030490)2.36129595
137respiratory electron transport chain (GO:0022904)2.35778960
138establishment of mitochondrion localization (GO:0051654)2.35355776
139neuron-neuron synaptic transmission (GO:0007270)2.35154819
140regulation of translational initiation (GO:0006446)2.34869531
141gluconeogenesis (GO:0006094)2.34782390
142peptidyl-arginine modification (GO:0018195)2.33506635
143protein K6-linked ubiquitination (GO:0085020)2.33060576
144pteridine-containing compound metabolic process (GO:0042558)2.33048131
145negative regulation of heart rate (GO:0010459)2.32616728
146protein deneddylation (GO:0000338)2.31831784
147establishment of melanosome localization (GO:0032401)2.30335549
148cellular response to glucose starvation (GO:0042149)2.30172184
149regulation of synaptic vesicle transport (GO:1902803)2.29577379
150sister chromatid segregation (GO:0000819)2.28968349
151regulation of nuclease activity (GO:0032069)2.28553877
152presynaptic membrane organization (GO:0097090)2.28210118
153regulation of tight junction assembly (GO:2000810)2.26902414
154regulation of glutamate receptor signaling pathway (GO:1900449)2.24781385
155heme biosynthetic process (GO:0006783)2.24723464
156endoplasmic reticulum unfolded protein response (GO:0030968)2.22140135
157negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.19613620
158melanosome transport (GO:0032402)2.19135132
159viral transcription (GO:0019083)2.17728939
160regulation of gene silencing by RNA (GO:0060966)2.17180428
161regulation of posttranscriptional gene silencing (GO:0060147)2.17180428
162regulation of gene silencing by miRNA (GO:0060964)2.17180428
163regulation of oxidative stress-induced neuron death (GO:1903203)2.17060772
164translational termination (GO:0006415)2.16861544
165protein complex disassembly (GO:0043241)2.16835523
166negative regulation of neurotransmitter transport (GO:0051589)2.16743920
167neurotransmitter transport (GO:0006836)2.15576584
168mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.15563738
169presynaptic membrane assembly (GO:0097105)2.15538481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.79149911
2EZH2_22144423_ChIP-Seq_EOC_Human3.26829784
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.12917442
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85888725
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83459660
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78023235
7THAP11_20581084_ChIP-Seq_MESCs_Mouse2.63904272
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.56635864
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43550335
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43435605
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38223062
12* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31675462
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.29141153
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.22264904
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21243112
16* XRN2_22483619_ChIP-Seq_HELA_Human2.10335987
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07790589
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.07742208
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98140552
20* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95068664
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.91405372
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.91017840
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90540130
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90538920
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87843895
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87300417
27* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86655540
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83378652
29CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.81646076
30ZNF263_19887448_ChIP-Seq_K562_Human1.80587739
31* SRF_21415370_ChIP-Seq_HL-1_Mouse1.79824610
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78493270
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77369180
34CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.75977363
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75869659
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74673448
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73461196
38* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72325907
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71399166
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68040263
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67656113
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64721824
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.61765695
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59650826
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59443410
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59202066
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57793498
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57212748
49TTF2_22483619_ChIP-Seq_HELA_Human1.53643464
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.50469814
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48558777
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.47990763
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45559188
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.45459992
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45157031
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44443992
57DCP1A_22483619_ChIP-Seq_HELA_Human1.44299262
58TFEB_21752829_ChIP-Seq_HELA_Human1.43453646
59GBX2_23144817_ChIP-Seq_PC3_Human1.43125766
60ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.41030470
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37905756
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33976655
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33788640
64E2F7_22180533_ChIP-Seq_HELA_Human1.33295802
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32160688
66* GABP_19822575_ChIP-Seq_HepG2_Human1.32082067
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31987763
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31187028
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29279878
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29089398
71REST_21632747_ChIP-Seq_MESCs_Mouse1.28965333
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28443415
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26181280
74* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25754061
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24210454
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.22076803
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21755137
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21589616
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21448911
80AR_21909140_ChIP-Seq_LNCAP_Human1.19985916
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.19437981
82VDR_23849224_ChIP-Seq_CD4+_Human1.18782473
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14997258
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.14806797
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14660730
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14346930
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14180547
88* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14140998
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12457819
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12098965
91ELK1_22589737_ChIP-Seq_MCF10A_Human1.10592879
92* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09433860
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09043201
94ELK1_19687146_ChIP-ChIP_HELA_Human1.07878422
95MYC_18940864_ChIP-ChIP_HL60_Human1.07331472
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06257242
97EZH2_27304074_Chip-Seq_ESCs_Mouse1.06226609
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04872683
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.04576983
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04407506
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03194653
102FOXP3_21729870_ChIP-Seq_TREG_Human1.02695132
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02268754
104NANOG_21062744_ChIP-ChIP_HESCs_Human1.00576167
105* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99800319
106* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99768468
107SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99167663
108* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98900248
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98582128
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97740793
111ZNF274_21170338_ChIP-Seq_K562_Hela0.97608216
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97529120
113SOX17_20123909_ChIP-Seq_XEN_Mouse0.96218622
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96080464
115KDM5A_27292631_Chip-Seq_BREAST_Human0.95872804
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.94040596
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93921945
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93876163
119CIITA_25753668_ChIP-Seq_RAJI_Human0.91846162
120* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91696824
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91660044
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91306029
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91284821
124CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91122046
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90565526
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90195294
127* ATF3_27146783_Chip-Seq_COLON_Human0.88812945
128BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88694192
129TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88624391
130CLOCK_20551151_ChIP-Seq_293T_Human0.87557743
131ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87098090
132PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85962244
133TP63_17297297_ChIP-ChIP_HaCaT_Human0.84700010
134* CHD1_26751641_Chip-Seq_LNCaP_Human0.79563263
135STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79544246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity2.74113941
2MP0004270_analgesia2.59670240
3MP0008058_abnormal_DNA_repair2.51684064
4MP0003283_abnormal_digestive_organ2.51582512
5MP0003880_abnormal_central_pattern2.43389289
6MP0003122_maternal_imprinting2.41648784
7MP0009046_muscle_twitch2.37659797
8MP0002064_seizures2.36993448
9MP0005623_abnormal_meninges_morphology2.34558709
10MP0003635_abnormal_synaptic_transmissio2.33565622
11MP0000013_abnormal_adipose_tissue2.14792192
12MP0002734_abnormal_mechanical_nocicepti2.06244827
13MP0008007_abnormal_cellular_replicative2.01233388
14MP0009745_abnormal_behavioral_response1.99183615
15MP0003786_premature_aging1.91876174
16MP0003111_abnormal_nucleus_morphology1.88341916
17MP0002063_abnormal_learning/memory/cond1.86945805
18MP0009780_abnormal_chondrocyte_physiolo1.80914280
19MP0003123_paternal_imprinting1.80746252
20MP0004133_heterotaxia1.78554165
21MP0002272_abnormal_nervous_system1.78064770
22MP0003787_abnormal_imprinting1.76545746
23MP0008438_abnormal_cutaneous_collagen1.73496689
24MP0001968_abnormal_touch/_nociception1.70977823
25MP0002736_abnormal_nociception_after1.69417322
26MP0003186_abnormal_redox_activity1.69011389
27MP0003077_abnormal_cell_cycle1.65893222
28MP0002572_abnormal_emotion/affect_behav1.65624076
29MP0003941_abnormal_skin_development1.65551090
30MP0002733_abnormal_thermal_nociception1.64156880
31MP0000566_synostosis1.62294236
32MP0010094_abnormal_chromosome_stability1.61037437
33MP0004858_abnormal_nervous_system1.60948680
34MP0001529_abnormal_vocalization1.54557289
35MP0001970_abnormal_pain_threshold1.53686980
36MP0004233_abnormal_muscle_weight1.50264807
37MP0002184_abnormal_innervation1.49419387
38MP0002234_abnormal_pharynx_morphology1.49108481
39MP0005171_absent_coat_pigmentation1.47164645
40MP0002102_abnormal_ear_morphology1.45998266
41MP0003121_genomic_imprinting1.44628154
42MP0004885_abnormal_endolymph1.43994115
43MP0000955_abnormal_spinal_cord1.43248470
44MP0004811_abnormal_neuron_physiology1.42106161
45MP0004957_abnormal_blastocyst_morpholog1.41048753
46MP0009379_abnormal_foot_pigmentation1.41019821
47MP0002909_abnormal_adrenal_gland1.39942372
48MP0006276_abnormal_autonomic_nervous1.38291309
49MP0002877_abnormal_melanocyte_morpholog1.38173816
50MP0001299_abnormal_eye_distance/1.37855474
51MP0006035_abnormal_mitochondrial_morpho1.37046605
52MP0001440_abnormal_grooming_behavior1.35865588
53MP0002067_abnormal_sensory_capabilities1.31807862
54MP0002735_abnormal_chemical_nociception1.30595440
55MP0005257_abnormal_intraocular_pressure1.29055561
56MP0002938_white_spotting1.27173416
57MP0000358_abnormal_cell_content/1.27067626
58MP0002822_catalepsy1.25811144
59MP0000778_abnormal_nervous_system1.25713700
60MP0003119_abnormal_digestive_system1.24519529
61MP0002837_dystrophic_cardiac_calcinosis1.20514602
62MP0000537_abnormal_urethra_morphology1.19868403
63MP0002882_abnormal_neuron_morphology1.19017919
64MP0004142_abnormal_muscle_tone1.18580098
65MP0000647_abnormal_sebaceous_gland1.18229050
66MP0005408_hypopigmentation1.18156745
67MP0002751_abnormal_autonomic_nervous1.15865553
68MP0008932_abnormal_embryonic_tissue1.14314610
69MP0002066_abnormal_motor_capabilities/c1.11879618
70MP0003329_amyloid_beta_deposits1.11356783
71MP0005499_abnormal_olfactory_system1.10473396
72MP0005394_taste/olfaction_phenotype1.10473396
73MP0002557_abnormal_social/conspecific_i1.09536778
74MP0005501_abnormal_skin_physiology1.09106839
75MP0002653_abnormal_ependyma_morphology1.09074349
76MP0010386_abnormal_urinary_bladder1.09039231
77MP0001905_abnormal_dopamine_level1.08365435
78MP0000003_abnormal_adipose_tissue1.05801605
79MP0002152_abnormal_brain_morphology1.04623090
80MP0003942_abnormal_urinary_system1.03680330
81MP0000750_abnormal_muscle_regeneration1.02896076
82MP0003693_abnormal_embryo_hatching1.01486402
83MP0000751_myopathy1.00403670
84MP0001486_abnormal_startle_reflex1.00261526
85MP0006072_abnormal_retinal_apoptosis0.99434394
86MP0001485_abnormal_pinna_reflex0.98625109
87MP0000350_abnormal_cell_proliferation0.97783787
88MP0001697_abnormal_embryo_size0.96984351
89MP0003385_abnormal_body_wall0.96363285
90MP0004043_abnormal_pH_regulation0.96311460
91MP0001661_extended_life_span0.95868858
92MP0003806_abnormal_nucleotide_metabolis0.95541069
93MP0001348_abnormal_lacrimal_gland0.94581005
94MP0002080_prenatal_lethality0.94498886
95MP0005275_abnormal_skin_tensile0.94434979
96MP0004924_abnormal_behavior0.93584357
97MP0005386_behavior/neurological_phenoty0.93584357
98MP0004134_abnormal_chest_morphology0.93385648
99MP0001243_abnormal_dermal_layer0.92102615
100MP0002295_abnormal_pulmonary_circulatio0.92045618
101MP0005423_abnormal_somatic_nervous0.91756935
102MP0010030_abnormal_orbit_morphology0.91711209
103MP0003718_maternal_effect0.91617295
104MP0003861_abnormal_nervous_system0.90692492
105MP0010234_abnormal_vibrissa_follicle0.90325870
106MP0002177_abnormal_outer_ear0.89554154
107MP0000579_abnormal_nail_morphology0.88782418
108MP0002060_abnormal_skin_morphology0.88322846
109MP0002090_abnormal_vision0.88051852
110MP0008789_abnormal_olfactory_epithelium0.86628980
111MP0003634_abnormal_glial_cell0.86597182
112MP0003221_abnormal_cardiomyocyte_apopto0.85954395
113MP0002085_abnormal_embryonic_tissue0.85559673
114MP0001730_embryonic_growth_arrest0.84651368
115MP0005645_abnormal_hypothalamus_physiol0.83632306
116MP0008995_early_reproductive_senescence0.83540719
117MP0000678_abnormal_parathyroid_gland0.83235025
118MP0003755_abnormal_palate_morphology0.82847089
119MP0001984_abnormal_olfaction0.80544101
120MP0001542_abnormal_bone_strength0.80480854
121MP0004272_abnormal_basement_membrane0.80447830
122MP0002697_abnormal_eye_size0.79613226
123MP0002638_abnormal_pupillary_reflex0.78588062
124MP0003632_abnormal_nervous_system0.78553993
125MP0005187_abnormal_penis_morphology0.78060240
126MP0006036_abnormal_mitochondrial_physio0.77386354
127MP0000749_muscle_degeneration0.77091078
128MP0008877_abnormal_DNA_methylation0.76994886
129MP0000747_muscle_weakness0.76303355
130MP0000377_abnormal_hair_follicle0.75933853
131MP0002229_neurodegeneration0.75436490
132MP0002269_muscular_atrophy0.75432802
133MP0003937_abnormal_limbs/digits/tail_de0.75336098
134MP0000372_irregular_coat_pigmentation0.75166148
135MP0005380_embryogenesis_phenotype0.75071459
136MP0001672_abnormal_embryogenesis/_devel0.75071459
137MP0000534_abnormal_ureter_morphology0.74878962
138MP0005503_abnormal_tendon_morphology0.74861285
139MP0000516_abnormal_urinary_system0.74754379
140MP0005367_renal/urinary_system_phenotyp0.74754379
141MP0002084_abnormal_developmental_patter0.74675545
142MP0004197_abnormal_fetal_growth/weight/0.73997644
143MP0001986_abnormal_taste_sensitivity0.73771058
144MP0008569_lethality_at_weaning0.73397235
145MP0001664_abnormal_digestion0.73088951
146MP0000428_abnormal_craniofacial_morphol0.71307309
147MP0001188_hyperpigmentation0.70749181
148MP0002069_abnormal_eating/drinking_beha0.70305469
149MP0002896_abnormal_bone_mineralization0.70230181
150MP0003705_abnormal_hypodermis_morpholog0.69771468
151MP0001943_abnormal_respiration0.69255772

Predicted human phenotypes

RankGene SetZ-score
1Atonic seizures (HP:0010819)3.33492486
2Limb dystonia (HP:0002451)3.32588581
3Morphological abnormality of the middle ear (HP:0008609)3.32106442
4Hand muscle atrophy (HP:0009130)3.25863844
5Abnormality of the lower motor neuron (HP:0002366)3.25816447
6Long foot (HP:0001833)3.25167113
7Focal motor seizures (HP:0011153)3.11812733
8Abnormality of the labia minora (HP:0012880)3.11564510
9Broad face (HP:0000283)3.08564823
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.06393344
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.06393344
12Abnormality of the heme biosynthetic pathway (HP:0010472)3.02164317
13Upper limb amyotrophy (HP:0009129)2.95404718
14Distal upper limb amyotrophy (HP:0007149)2.95404718
15Resting tremor (HP:0002322)2.89792832
16Generalized hypotonia (HP:0001290)2.87364104
17Acute encephalopathy (HP:0006846)2.81601791
18Supranuclear gaze palsy (HP:0000605)2.72446838
19Hypoventilation (HP:0002791)2.69356060
20Hyperacusis (HP:0010780)2.68500877
21Abnormality of pain sensation (HP:0010832)2.67904766
22Impaired pain sensation (HP:0007328)2.67904766
23Paralysis (HP:0003470)2.66936740
24Failure to thrive in infancy (HP:0001531)2.63073656
25Cerebral hypomyelination (HP:0006808)2.61377823
26Abnormality of glycolysis (HP:0004366)2.53000047
27Increased serum pyruvate (HP:0003542)2.53000047
28Increased CSF lactate (HP:0002490)2.47330709
29Hepatic necrosis (HP:0002605)2.46765085
30Pheochromocytoma (HP:0002666)2.46500386
31Visual hallucinations (HP:0002367)2.44058864
32Cerebral palsy (HP:0100021)2.43454906
33Microvesicular hepatic steatosis (HP:0001414)2.33417038
34Abnormal mitochondria in muscle tissue (HP:0008316)2.32850153
35Entropion (HP:0000621)2.32486910
36Acute necrotizing encephalopathy (HP:0006965)2.32288337
37Focal seizures (HP:0007359)2.30881013
38Insidious onset (HP:0003587)2.29835934
39Termporal pattern (HP:0011008)2.29835934
40Hypsarrhythmia (HP:0002521)2.28444551
41Epileptiform EEG discharges (HP:0011182)2.27802723
42Epileptic encephalopathy (HP:0200134)2.27408955
43EEG with generalized epileptiform discharges (HP:0011198)2.27099506
44Neuroendocrine neoplasm (HP:0100634)2.18777928
45Tented upper lip vermilion (HP:0010804)2.18482790
46Premature rupture of membranes (HP:0001788)2.18187415
47Hypokinesia (HP:0002375)2.17644157
48Overlapping toe (HP:0001845)2.16463057
49Emotional lability (HP:0000712)2.14827932
50Degeneration of anterior horn cells (HP:0002398)2.13081333
51Abnormality of the anterior horn cell (HP:0006802)2.13081333
52Cerebral edema (HP:0002181)2.13060523
53Astrocytoma (HP:0009592)2.11968285
54Abnormality of the astrocytes (HP:0100707)2.11968285
55Abnormal gallbladder morphology (HP:0012437)2.10428762
56Absence seizures (HP:0002121)2.10242163
57Cholelithiasis (HP:0001081)2.09656844
58Progressive macrocephaly (HP:0004481)2.09333442
59Hypoplasia of the pons (HP:0012110)2.05925368
60Hypoglycemic coma (HP:0001325)2.04407284
61Delayed gross motor development (HP:0002194)2.02843099
62Increased serum lactate (HP:0002151)2.01308748
63Truncal ataxia (HP:0002078)1.99291893
64Upper limb muscle weakness (HP:0003484)1.97411399
65Postnatal microcephaly (HP:0005484)1.96312561
66Increased hepatocellular lipid droplets (HP:0006565)1.96099719
67Abnormality of the metopic suture (HP:0005556)1.94170506
68Myokymia (HP:0002411)1.93256792
69Insomnia (HP:0100785)1.93252901
70Autoamputation (HP:0001218)1.91927904
71Abnormality of the pons (HP:0007361)1.91666833
72Sparse eyelashes (HP:0000653)1.90813997
73Ankle clonus (HP:0011448)1.90558325
74Shoulder girdle muscle weakness (HP:0003547)1.89511023
75Athetosis (HP:0002305)1.88808328
76Neoplasm of the peripheral nervous system (HP:0100007)1.88223305
77Hepatocellular necrosis (HP:0001404)1.87105467
78Follicular hyperkeratosis (HP:0007502)1.86828802
79Unilateral renal agenesis (HP:0000122)1.86543117
80Ependymoma (HP:0002888)1.86130443
81Prominent metopic ridge (HP:0005487)1.85625401
82Cerebral inclusion bodies (HP:0100314)1.85519098
83Dialeptic seizures (HP:0011146)1.85175324
84Cortical dysplasia (HP:0002539)1.84606678
85Postural tremor (HP:0002174)1.84469599
86Hyperinsulinemic hypoglycemia (HP:0000825)1.83868568
87Lactic acidosis (HP:0003128)1.83516928
88Hypoplastic pelvis (HP:0008839)1.83326484
89Large hands (HP:0001176)1.81169868
90Urinary urgency (HP:0000012)1.79718308
91Lissencephaly (HP:0001339)1.79627279
92Mitochondrial inheritance (HP:0001427)1.79107360
93Exercise intolerance (HP:0003546)1.78642334
94Degeneration of the lateral corticospinal tracts (HP:0002314)1.78016811
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78016811
96Hyperthyroidism (HP:0000836)1.76784880
97Cutaneous melanoma (HP:0012056)1.76197011
98Leukodystrophy (HP:0002415)1.76004169
99Large eyes (HP:0001090)1.74338288
100Buphthalmos (HP:0000557)1.73663952
101CNS hypomyelination (HP:0003429)1.73440786
102Delayed myelination (HP:0012448)1.73215460
103Muscular hypotonia of the trunk (HP:0008936)1.73185920
104Secondary amenorrhea (HP:0000869)1.72747457
105Depression (HP:0000716)1.72702237
106Delayed closure of the anterior fontanelle (HP:0001476)1.71534047
107Impaired vibration sensation in the lower limbs (HP:0002166)1.70628752
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70600056
109Abnormal protein N-linked glycosylation (HP:0012347)1.70600056
110Abnormal protein glycosylation (HP:0012346)1.70600056
111Abnormal glycosylation (HP:0012345)1.70600056
112Hypoplasia of the brainstem (HP:0002365)1.70082894
113Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70082894
114Protrusio acetabuli (HP:0003179)1.69658874
115Redundant skin (HP:0001582)1.68986834
116Ankle contracture (HP:0006466)1.68376456
117Adrenal hypoplasia (HP:0000835)1.67717380
118Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67386104
119Reticulocytopenia (HP:0001896)1.66953214
120Type I transferrin isoform profile (HP:0003642)1.66925606
121Abnormality of dentin (HP:0010299)1.66685122
122Spastic gait (HP:0002064)1.66096823
123Tongue fasciculations (HP:0001308)1.64956078
124Apathy (HP:0000741)1.64917484
125Hammertoe (HP:0001765)1.64683739
126Cholecystitis (HP:0001082)1.64594244
127Abnormal gallbladder physiology (HP:0012438)1.64594244
128Rapidly progressive (HP:0003678)1.64367722
129Abnormality of the vocal cords (HP:0008777)1.64359674
130Sensory axonal neuropathy (HP:0003390)1.64219897
1313-Methylglutaconic aciduria (HP:0003535)1.63291672
132Poor suck (HP:0002033)1.61786611
133Lipid accumulation in hepatocytes (HP:0006561)1.60341603
134Respiratory failure (HP:0002878)1.60151535
135Angiofibromas (HP:0010615)1.59683191
136Adenoma sebaceum (HP:0009720)1.59683191
137Broad alveolar ridges (HP:0000187)1.59492037
138Specific learning disability (HP:0001328)1.59020553
139Open mouth (HP:0000194)1.58843923
140Abnormalities of placenta or umbilical cord (HP:0001194)1.58750447
141Narrow nasal bridge (HP:0000446)1.57846682
142Abnormality of reticulocytes (HP:0004312)1.56861340
143Febrile seizures (HP:0002373)1.56720514
144Delusions (HP:0000746)1.56017355
145Amblyopia (HP:0000646)1.55900495
146Shallow orbits (HP:0000586)1.54813149
147Spastic tetraplegia (HP:0002510)1.53885292
148Amniotic constriction ring (HP:0009775)1.53188072
149Abnormality of placental membranes (HP:0011409)1.53188072
150Pterygium (HP:0001059)1.52914067
151Abnormality of the gallbladder (HP:0005264)1.52632862
152Reticulocytosis (HP:0001923)1.52080979
153Increased intramyocellular lipid droplets (HP:0012240)1.51941800
154Retinal dysplasia (HP:0007973)1.51422564
155Deformed tarsal bones (HP:0008119)1.50906944
156Atrophy/Degeneration involving motor neurons (HP:0007373)1.49624226
157Cortical visual impairment (HP:0100704)1.49125761
158Diminished movement (HP:0002374)1.47692787
159Distal sensory impairment (HP:0002936)1.47205840
160Calcaneovalgus deformity (HP:0001848)1.46117396
161Unsteady gait (HP:0002317)1.44787551
162Squamous cell carcinoma (HP:0002860)1.44587623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.35073420
2TSSK63.56363458
3MAP3K43.47728858
4CASK2.93009300
5MAP2K72.92717560
6STK162.88647010
7TRIM282.73035134
8MAP3K22.57825428
9LIMK12.57052381
10PBK2.39582850
11NTRK32.38371276
12BUB12.28296747
13NEK12.21001965
14SCYL22.20322019
15PIM22.07268954
16PASK1.97952125
17EPHA21.96343807
18VRK21.82343253
19EEF2K1.79804345
20CDK191.76168279
21AKT31.68410482
22MARK11.67585626
23PLK31.50328782
24NTRK11.50081190
25PKN21.44140821
26MINK11.43631659
27SRPK11.39336143
28NME21.39266422
29PLK21.34832429
30LRRK21.33684020
31PNCK1.33520739
32DDR21.29803855
33UHMK11.28249502
34BRSK11.28170793
35MAP2K41.27824147
36MAP4K21.26644785
37PRPF4B1.24250855
38NME11.23105115
39TLK11.22857828
40DAPK31.19008127
41LATS21.17629127
42SIK31.14899537
43SIK21.14072426
44MAP3K121.11518890
45LMTK21.11034189
46CDK181.08375831
47CDK141.08091410
48CDK151.07145745
49AURKA1.06072065
50TESK11.04773845
51MAP3K91.03550222
52MET1.02574181
53TTN1.01650555
54ERBB41.01218395
55ROCK21.00017706
56PDK30.99683096
57PDK40.99683096
58ERBB30.99254390
59TTK0.98871946
60PAK60.98863332
61CLK10.95859491
62PHKG10.95645479
63PHKG20.95645479
64CSNK1A1L0.94507630
65FER0.94292876
66CDK11A0.93639440
67TESK20.92550664
68DAPK20.88733313
69CSNK1G10.87698581
70CDC70.87604984
71BCR0.87522424
72ALK0.86588809
73OXSR10.84594040
74DAPK10.83851373
75SGK2230.83691837
76SGK4940.83691837
77RET0.83044860
78EPHA40.82794143
79BRAF0.82282561
80CDK50.80131942
81GRK50.79080646
82MYLK0.77250105
83PRKCG0.77189885
84PTK20.77089811
85INSRR0.75485840
86KSR20.74875425
87TRIB30.73397246
88CAMK2B0.72657403
89RPS6KB20.72325943
90CSNK1E0.72224830
91MST1R0.71727597
92PINK10.71339344
93PAK40.70341517
94CCNB10.68602302
95CHEK10.65024645
96CSNK1G30.63373344
97PKN10.63131663
98PDGFRA0.63095072
99ICK0.62098623
100ATR0.61894865
101VRK10.61541220
102EPHB20.61171875
103FLT30.60801135
104PRKD30.59590017
105AURKB0.58517439
106PAK10.58270803
107ILK0.57983934
108WNK40.57773198
109PAK30.57591323
110FGFR10.56685721
111ADRBK10.56082444
112PRKCI0.55865497
113ARAF0.55589111
114BMX0.53470598
115CSNK2A20.52258168
116CAMK2G0.52239928
117ATM0.51963465
118FGR0.51429831
119PLK10.50855396
120STK390.50596522
121CSNK1G20.49108799
122MUSK0.47976963
123MARK20.47611484
124WEE10.47408870
125CHEK20.46075175
126CDK80.45385758
127NEK60.44622971
128KSR10.44581146
129MAP3K100.44461481
130PAK20.44353588
131MAPKAPK30.44265130
132TYRO30.43722734
133MAP3K80.43704433
134PRKCE0.43613038
135DYRK20.42925463
136MST40.42891443
137PRKD20.42822050
138IRAK30.42643018
139PDK20.42045706
140CSNK2A10.41846495
141EIF2AK30.41424992
142CAMK2A0.41127042
143RAF10.40110209
144MAP2K10.40024774
145BRSK20.38797305
146EIF2AK20.38550928

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.43659433
2Collecting duct acid secretion_Homo sapiens_hsa049663.32324722
3* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.95363245
4Vibrio cholerae infection_Homo sapiens_hsa051102.85589526
5Oxidative phosphorylation_Homo sapiens_hsa001902.66110126
6Vitamin B6 metabolism_Homo sapiens_hsa007502.42471487
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09162601
8Proteasome_Homo sapiens_hsa030502.08331377
9Parkinsons disease_Homo sapiens_hsa050122.01630951
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.95293708
11Nicotine addiction_Homo sapiens_hsa050331.82712890
12Selenocompound metabolism_Homo sapiens_hsa004501.66014768
13Alzheimers disease_Homo sapiens_hsa050101.62411570
14Ribosome_Homo sapiens_hsa030101.60195197
15GABAergic synapse_Homo sapiens_hsa047271.57501490
16Dopaminergic synapse_Homo sapiens_hsa047281.54066667
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46157311
18Basal transcription factors_Homo sapiens_hsa030221.45725274
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45263315
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44387537
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42564445
22Fatty acid elongation_Homo sapiens_hsa000621.41153077
23Long-term potentiation_Homo sapiens_hsa047201.40862419
24DNA replication_Homo sapiens_hsa030301.39511594
25Amphetamine addiction_Homo sapiens_hsa050311.36808792
26Steroid biosynthesis_Homo sapiens_hsa001001.35723955
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34619134
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32667203
29Huntingtons disease_Homo sapiens_hsa050161.30894981
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.29856821
31Cocaine addiction_Homo sapiens_hsa050301.24951520
32Spliceosome_Homo sapiens_hsa030401.23178757
33Alcoholism_Homo sapiens_hsa050341.23069941
34RNA transport_Homo sapiens_hsa030131.21316695
35Non-homologous end-joining_Homo sapiens_hsa034501.20061647
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18537028
37Insulin secretion_Homo sapiens_hsa049111.18027067
38Gap junction_Homo sapiens_hsa045401.16760498
39Oocyte meiosis_Homo sapiens_hsa041141.15882866
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15880077
41Protein export_Homo sapiens_hsa030601.14751202
42Folate biosynthesis_Homo sapiens_hsa007901.14039336
43One carbon pool by folate_Homo sapiens_hsa006701.14019505
44Pyrimidine metabolism_Homo sapiens_hsa002401.13949087
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11904240
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.08953931
47N-Glycan biosynthesis_Homo sapiens_hsa005101.08444388
48Phagosome_Homo sapiens_hsa041451.08384117
49Bladder cancer_Homo sapiens_hsa052191.07380603
50Type I diabetes mellitus_Homo sapiens_hsa049401.06574438
51Pentose phosphate pathway_Homo sapiens_hsa000301.04247874
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03497726
53Morphine addiction_Homo sapiens_hsa050321.03345588
54RNA degradation_Homo sapiens_hsa030181.00112728
55Cholinergic synapse_Homo sapiens_hsa047250.99403035
56Long-term depression_Homo sapiens_hsa047300.95630810
57Circadian entrainment_Homo sapiens_hsa047130.94445953
58Glioma_Homo sapiens_hsa052140.94269079
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93952436
60Biosynthesis of amino acids_Homo sapiens_hsa012300.93864586
61Propanoate metabolism_Homo sapiens_hsa006400.93698953
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93359021
63Serotonergic synapse_Homo sapiens_hsa047260.92743045
64Base excision repair_Homo sapiens_hsa034100.91953843
65Glutamatergic synapse_Homo sapiens_hsa047240.90128610
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90018244
67Estrogen signaling pathway_Homo sapiens_hsa049150.85901858
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.85544445
69Sulfur relay system_Homo sapiens_hsa041220.83281623
70Melanoma_Homo sapiens_hsa052180.81197303
71Axon guidance_Homo sapiens_hsa043600.81140421
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80874498
73Pyruvate metabolism_Homo sapiens_hsa006200.79816370
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79278926
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79175140
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78826685
77ErbB signaling pathway_Homo sapiens_hsa040120.78412052
78mRNA surveillance pathway_Homo sapiens_hsa030150.76688329
79Butanoate metabolism_Homo sapiens_hsa006500.76365441
80Renal cell carcinoma_Homo sapiens_hsa052110.75877268
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.74909067
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73973808
83Taste transduction_Homo sapiens_hsa047420.73843006
84Arginine biosynthesis_Homo sapiens_hsa002200.72791299
85Homologous recombination_Homo sapiens_hsa034400.72273054
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71511593
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71212975
88Rheumatoid arthritis_Homo sapiens_hsa053230.70840285
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70651893
90Purine metabolism_Homo sapiens_hsa002300.69705723
91Tight junction_Homo sapiens_hsa045300.69254473
92GnRH signaling pathway_Homo sapiens_hsa049120.69244665
93Olfactory transduction_Homo sapiens_hsa047400.68886922
94Cardiac muscle contraction_Homo sapiens_hsa042600.68529976
95Arginine and proline metabolism_Homo sapiens_hsa003300.67443058
96Metabolic pathways_Homo sapiens_hsa011000.65822417
97Type II diabetes mellitus_Homo sapiens_hsa049300.63670691
98Fanconi anemia pathway_Homo sapiens_hsa034600.63578247
99Colorectal cancer_Homo sapiens_hsa052100.63496119
100Hedgehog signaling pathway_Homo sapiens_hsa043400.63486629
101Carbon metabolism_Homo sapiens_hsa012000.63106637
102Melanogenesis_Homo sapiens_hsa049160.61743859
103Oxytocin signaling pathway_Homo sapiens_hsa049210.61410321
104Viral carcinogenesis_Homo sapiens_hsa052030.61362647
105p53 signaling pathway_Homo sapiens_hsa041150.61276237
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61049283
107Gastric acid secretion_Homo sapiens_hsa049710.61022011
108Regulation of autophagy_Homo sapiens_hsa041400.60995840
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58925769
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56702192
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56443947
112mTOR signaling pathway_Homo sapiens_hsa041500.56317919
113Glutathione metabolism_Homo sapiens_hsa004800.56145651
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55843711
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.55796805
116Cell cycle_Homo sapiens_hsa041100.54944722
117Nucleotide excision repair_Homo sapiens_hsa034200.52875853
118Renin secretion_Homo sapiens_hsa049240.52471056
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52309476
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.51415054
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50690562
122Sulfur metabolism_Homo sapiens_hsa009200.50161619
123Endocytosis_Homo sapiens_hsa041440.49898196
124Galactose metabolism_Homo sapiens_hsa000520.49013734
125Fatty acid metabolism_Homo sapiens_hsa012120.48189893
126Hippo signaling pathway_Homo sapiens_hsa043900.47332706
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46829403
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46795937
129HIF-1 signaling pathway_Homo sapiens_hsa040660.46533133
130Salivary secretion_Homo sapiens_hsa049700.46380353
131Mismatch repair_Homo sapiens_hsa034300.45811679
132Pancreatic secretion_Homo sapiens_hsa049720.45718774
133RNA polymerase_Homo sapiens_hsa030200.44877208
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41023729
135Endometrial cancer_Homo sapiens_hsa052130.40291655
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38454592
137Fructose and mannose metabolism_Homo sapiens_hsa000510.38212033
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37483904
139MAPK signaling pathway_Homo sapiens_hsa040100.37363711
140Circadian rhythm_Homo sapiens_hsa047100.35321793
141AMPK signaling pathway_Homo sapiens_hsa041520.28987820
142Prion diseases_Homo sapiens_hsa050200.25861502
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.25675125
144Peroxisome_Homo sapiens_hsa041460.22048417

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