SARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.49828479
2ribosomal small subunit assembly (GO:0000028)4.68592183
3DNA replication initiation (GO:0006270)4.64524085
4DNA strand elongation involved in DNA replication (GO:0006271)4.64282321
5formation of translation preinitiation complex (GO:0001731)4.55954318
6telomere maintenance via semi-conservative replication (GO:0032201)4.41163189
7DNA strand elongation (GO:0022616)4.39360019
8DNA unwinding involved in DNA replication (GO:0006268)4.38990410
9peptidyl-arginine omega-N-methylation (GO:0035247)4.34428961
10nucleobase biosynthetic process (GO:0046112)4.31262707
11DNA replication checkpoint (GO:0000076)4.30946209
12ribosome biogenesis (GO:0042254)4.20762889
13maturation of SSU-rRNA (GO:0030490)4.18065446
14histone arginine methylation (GO:0034969)3.96895666
15L-serine metabolic process (GO:0006563)3.86436061
16purine nucleobase biosynthetic process (GO:0009113)3.84287342
17IMP biosynthetic process (GO:0006188)3.81547402
18regulation of mitochondrial translation (GO:0070129)3.81308521
19ribonucleoprotein complex biogenesis (GO:0022613)3.79330529
20telomere maintenance via recombination (GO:0000722)3.79125654
21pseudouridine synthesis (GO:0001522)3.76572641
22regulation of translational fidelity (GO:0006450)3.73023815
23pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.66392478
24pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.61815502
25mitotic recombination (GO:0006312)3.57287680
26proteasome assembly (GO:0043248)3.54887947
27heterochromatin organization (GO:0070828)3.52916047
28pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.52180502
29spliceosomal snRNP assembly (GO:0000387)3.50426267
30viral transcription (GO:0019083)3.49583983
31regulation of nuclear cell cycle DNA replication (GO:0033262)3.49499919
32peptidyl-arginine methylation (GO:0018216)3.48808713
33peptidyl-arginine N-methylation (GO:0035246)3.48808713
34telomere maintenance via telomere lengthening (GO:0010833)3.48434207
35viral mRNA export from host cell nucleus (GO:0046784)3.46326300
36nucleotide-excision repair, DNA gap filling (GO:0006297)3.45553513
37transcription-coupled nucleotide-excision repair (GO:0006283)3.45095367
38protein localization to chromosome, centromeric region (GO:0071459)3.41773229
39translational termination (GO:0006415)3.41240310
40ribosomal large subunit biogenesis (GO:0042273)3.40947297
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.40414312
42ribosomal small subunit biogenesis (GO:0042274)3.39397573
43pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.39279445
44termination of RNA polymerase III transcription (GO:0006386)3.37617044
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.37617044
46mitotic chromosome condensation (GO:0007076)3.36684485
47mitotic metaphase plate congression (GO:0007080)3.36289960
48folic acid-containing compound biosynthetic process (GO:0009396)3.35750604
49rRNA processing (GO:0006364)3.34616616
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.33134941
51CTP metabolic process (GO:0046036)3.31747572
52CTP biosynthetic process (GO:0006241)3.31747572
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29572315
54negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.28607447
55nucleosome disassembly (GO:0006337)3.28004136
56protein-DNA complex disassembly (GO:0032986)3.28004136
57kinetochore assembly (GO:0051382)3.27530036
58translational initiation (GO:0006413)3.25790442
597-methylguanosine mRNA capping (GO:0006370)3.23659813
60IMP metabolic process (GO:0046040)3.22632120
61transcription from RNA polymerase I promoter (GO:0006360)3.22522503
62rRNA metabolic process (GO:0016072)3.22384299
63regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21277592
64translational elongation (GO:0006414)3.20308893
65establishment of viral latency (GO:0019043)3.19258886
66chromatin remodeling at centromere (GO:0031055)3.19085354
67kinetochore organization (GO:0051383)3.18547711
68CENP-A containing nucleosome assembly (GO:0034080)3.18231747
69mitotic nuclear envelope disassembly (GO:0007077)3.17130964
70UTP biosynthetic process (GO:0006228)3.16966757
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16913183
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14966400
73RNA capping (GO:0036260)3.14192501
747-methylguanosine RNA capping (GO:0009452)3.14192501
75establishment of protein localization to mitochondrial membrane (GO:0090151)3.13904801
76chaperone-mediated protein transport (GO:0072321)3.12050755
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10875969
78ribosome assembly (GO:0042255)3.09819809
79protein complex disassembly (GO:0043241)3.09374735
80protein localization to kinetochore (GO:0034501)3.08987676
81cellular protein complex disassembly (GO:0043624)3.08823609
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07758588
83DNA damage response, detection of DNA damage (GO:0042769)3.07184874
84cellular component biogenesis (GO:0044085)3.05982911
85establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05906871
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05625789
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05625789
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05625789
89DNA replication-dependent nucleosome assembly (GO:0006335)3.05045001
90DNA replication-dependent nucleosome organization (GO:0034723)3.05045001
91viral life cycle (GO:0019058)3.04829199
92DNA replication-independent nucleosome organization (GO:0034724)3.04312440
93DNA replication-independent nucleosome assembly (GO:0006336)3.04312440
94intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04101738
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04101738
96regulation of double-strand break repair via homologous recombination (GO:0010569)3.02669645
97signal transduction involved in DNA damage checkpoint (GO:0072422)3.01945275
98signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01945275
99base-excision repair (GO:0006284)3.01872015
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01114995
101signal transduction involved in cell cycle checkpoint (GO:0072395)3.00980358
102establishment of integrated proviral latency (GO:0075713)3.00871715
103protein localization to endoplasmic reticulum (GO:0070972)3.00786960
104somatic hypermutation of immunoglobulin genes (GO:0016446)3.00583575
105somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00583575
106translation (GO:0006412)3.00088362
107mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99026202
108proline biosynthetic process (GO:0006561)2.99009308
109maturation of 5.8S rRNA (GO:0000460)2.98988900
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97981934
111negative regulation of ligase activity (GO:0051352)2.97981934
112sister chromatid segregation (GO:0000819)2.97887986
113DNA-templated transcription, termination (GO:0006353)2.97640779
114protein maturation by protein folding (GO:0022417)2.96950799
115termination of RNA polymerase II transcription (GO:0006369)2.96780148
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.96278204
117SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96250371
118rRNA transcription (GO:0009303)2.94847157
119protein targeting to mitochondrion (GO:0006626)2.94814022
120RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94401491
121mRNA splicing, via spliceosome (GO:0000398)2.94401491
122negative regulation of mRNA processing (GO:0050686)2.94172833
123RNA splicing, via transesterification reactions (GO:0000375)2.93867651
124termination of RNA polymerase I transcription (GO:0006363)2.93354812
125rRNA modification (GO:0000154)2.93074140
126chromatin assembly (GO:0031497)2.91499320
127ncRNA 3-end processing (GO:0043628)2.90787442
128DNA strand renaturation (GO:0000733)2.90695192
129macromolecular complex disassembly (GO:0032984)2.89974753
130spliceosomal complex assembly (GO:0000245)2.89645292
131pyrimidine nucleotide catabolic process (GO:0006244)2.89605620
132UTP metabolic process (GO:0046051)2.89585589
133energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89324295
134ATP synthesis coupled proton transport (GO:0015986)2.89324295
135guanosine-containing compound biosynthetic process (GO:1901070)2.89159958
136mitotic sister chromatid segregation (GO:0000070)2.88461369
137folic acid metabolic process (GO:0046655)2.87824602
138tRNA methylation (GO:0030488)2.87654165
139cotranslational protein targeting to membrane (GO:0006613)2.87453291
140G1/S transition of mitotic cell cycle (GO:0000082)2.87224023
141cell cycle G1/S phase transition (GO:0044843)2.87224023
142nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87143303
143negative regulation of RNA splicing (GO:0033119)2.86787414
144oxidative phosphorylation (GO:0006119)2.86233725
145exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84667806
146protein targeting to ER (GO:0045047)2.84585183
147metaphase plate congression (GO:0051310)2.84492988
148pentose metabolic process (GO:0019321)2.82049758
149tRNA modification (GO:0006400)2.81222811
150nuclear envelope disassembly (GO:0051081)2.80675669
151membrane disassembly (GO:0030397)2.80675669

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.36986286
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.18047812
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82136985
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20806720
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11782240
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09720460
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.98612809
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97314106
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95789966
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93710399
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.90774636
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.87560854
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.84653311
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83205114
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64326758
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63887812
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62471703
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45726505
19XRN2_22483619_ChIP-Seq_HELA_Human2.43908919
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33035153
21VDR_23849224_ChIP-Seq_CD4+_Human2.23753356
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22474723
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21166147
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19682219
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10744885
26* YY1_21170310_ChIP-Seq_MESCs_Mouse2.10487685
27FOXP3_21729870_ChIP-Seq_TREG_Human2.08660646
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05883914
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96964730
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94689631
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92623147
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89587363
33GABP_19822575_ChIP-Seq_HepG2_Human1.88489034
34DCP1A_22483619_ChIP-Seq_HELA_Human1.88004750
35CIITA_25753668_ChIP-Seq_RAJI_Human1.86432399
36MYC_22102868_ChIP-Seq_BL_Human1.82491706
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79314144
38* SRF_21415370_ChIP-Seq_HL-1_Mouse1.77697711
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76916066
40TTF2_22483619_ChIP-Seq_HELA_Human1.75624588
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75347353
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.67537846
43* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65608441
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65221738
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62776767
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61881262
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56664254
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56565656
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.55857786
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55696517
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55102992
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53966554
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51400424
54AR_21909140_ChIP-Seq_LNCAP_Human1.49538672
55KDM5A_27292631_Chip-Seq_BREAST_Human1.45585924
56* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44615527
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43276521
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.42969830
59ELK1_19687146_ChIP-ChIP_HELA_Human1.42326935
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42190924
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40982798
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39843914
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.36989455
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36942376
65LXR_22292898_ChIP-Seq_THP-1_Human1.36437772
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36343008
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35441331
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35154943
69* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33429193
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.33017773
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30537440
72ZNF263_19887448_ChIP-Seq_K562_Human1.26638401
73P68_20966046_ChIP-Seq_HELA_Human1.25223626
74FOXP1_21924763_ChIP-Seq_HESCs_Human1.24097305
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24003250
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21349106
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20655248
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20121488
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19369843
80TFEB_21752829_ChIP-Seq_HELA_Human1.19252278
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15742519
82VDR_21846776_ChIP-Seq_THP-1_Human1.15212025
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14793924
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11575682
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08009866
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07736703
87CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07360600
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06239319
89* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02380316
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02172098
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01783350
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00670320
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99596136
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99395203
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.99046219
96SPI1_23547873_ChIP-Seq_NB4_Human0.98823394
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97616108
98ELK3_25401928_ChIP-Seq_HUVEC_Human0.97239188
99RACK7_27058665_Chip-Seq_MCF-7_Human0.96739469
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96551151
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95725035
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95404881
103* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95400558
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.95016105
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94245864
106MYC_18940864_ChIP-ChIP_HL60_Human0.93723001
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92539450
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91898617
109RARA_24833708_ChIP-Seq_LIVER_Mouse0.91887866
110PHF8_20622854_ChIP-Seq_HELA_Human0.91731828
111OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90813676
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89885150
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89789728
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89147323
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88804330
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88620776
117* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87255011
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86388286
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84548526
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84406109
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81846694
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81294650
123* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81260445
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81134850
125RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80818879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.31663597
2MP0010094_abnormal_chromosome_stability4.44925409
3MP0003111_abnormal_nucleus_morphology4.31767729
4MP0004957_abnormal_blastocyst_morpholog4.15139560
5MP0008057_abnormal_DNA_replication3.84741214
6MP0003077_abnormal_cell_cycle3.75226549
7MP0008058_abnormal_DNA_repair3.32370060
8MP0003806_abnormal_nucleotide_metabolis3.21750013
9MP0008007_abnormal_cellular_replicative2.63648846
10MP0008932_abnormal_embryonic_tissue2.54313307
11MP0003786_premature_aging2.46151001
12MP0002396_abnormal_hematopoietic_system2.30533824
13MP0006292_abnormal_olfactory_placode2.28522788
14MP0005075_abnormal_melanosome_morpholog2.23250248
15MP0001730_embryonic_growth_arrest2.12112455
16MP0000350_abnormal_cell_proliferation1.96352920
17MP0008877_abnormal_DNA_methylation1.91492333
18MP0002653_abnormal_ependyma_morphology1.88499284
19MP0009379_abnormal_foot_pigmentation1.84112627
20MP0000678_abnormal_parathyroid_gland1.74679997
21MP0009672_abnormal_birth_weight1.73388883
22MP0009333_abnormal_splenocyte_physiolog1.70297486
23MP0000490_abnormal_crypts_of1.67121978
24MP0001835_abnormal_antigen_presentation1.66131572
25MP0010030_abnormal_orbit_morphology1.62988103
26MP0003718_maternal_effect1.61444394
27MP0003763_abnormal_thymus_physiology1.60886984
28MP0000313_abnormal_cell_death1.58420011
29MP0002249_abnormal_larynx_morphology1.56683321
30MP0008995_early_reproductive_senescence1.56625102
31MP0003123_paternal_imprinting1.56128870
32MP0003186_abnormal_redox_activity1.55695589
33MP0004185_abnormal_adipocyte_glucose1.54743620
34MP0002019_abnormal_tumor_incidence1.51111107
35MP0004133_heterotaxia1.44795213
36MP0005380_embryogenesis_phenotype1.43946583
37MP0001672_abnormal_embryogenesis/_devel1.43946583
38MP0002132_abnormal_respiratory_system1.41563610
39MP0002398_abnormal_bone_marrow1.37630111
40MP0002080_prenatal_lethality1.37231680
41MP0001697_abnormal_embryo_size1.36451021
42MP0005501_abnormal_skin_physiology1.36273989
43MP0004233_abnormal_muscle_weight1.35066971
44MP0002722_abnormal_immune_system1.32070703
45MP0010352_gastrointestinal_tract_polyps1.31265963
46MP0003984_embryonic_growth_retardation1.31206980
47MP0002163_abnormal_gland_morphology1.30059824
48MP0001545_abnormal_hematopoietic_system1.29975936
49MP0005397_hematopoietic_system_phenotyp1.29975936
50MP0003136_yellow_coat_color1.28709179
51MP0001661_extended_life_span1.27910617
52MP0000689_abnormal_spleen_morphology1.27562894
53MP0003890_abnormal_embryonic-extraembry1.25870202
54MP0002088_abnormal_embryonic_growth/wei1.25656789
55MP0003567_abnormal_fetal_cardiomyocyte1.25467091
56MP0000703_abnormal_thymus_morphology1.24078484
57MP0001293_anophthalmia1.23999665
58MP0002085_abnormal_embryonic_tissue1.23834948
59MP0003942_abnormal_urinary_system1.23059407
60MP0003122_maternal_imprinting1.14270707
61MP0002429_abnormal_blood_cell1.11885672
62MP0002210_abnormal_sex_determination1.10399358
63MP0002111_abnormal_tail_morphology1.10185109
64MP0008789_abnormal_olfactory_epithelium1.09487863
65MP0000537_abnormal_urethra_morphology1.08949649
66MP0009697_abnormal_copulation1.04348964
67MP0000716_abnormal_immune_system1.04125741
68MP0003861_abnormal_nervous_system1.02615406
69MP0000685_abnormal_immune_system1.02582244
70MP0001849_ear_inflammation1.02158796
71MP0002086_abnormal_extraembryonic_tissu1.02033085
72MP0005670_abnormal_white_adipose1.01788946
73MP0006036_abnormal_mitochondrial_physio0.99827539
74MP0000538_abnormal_urinary_bladder0.99078500
75MP0004197_abnormal_fetal_growth/weight/0.98771394
76MP0000747_muscle_weakness0.98287269
77MP0001800_abnormal_humoral_immune0.97910810
78MP0003937_abnormal_limbs/digits/tail_de0.94998262
79MP0002697_abnormal_eye_size0.94942548
80MP0002084_abnormal_developmental_patter0.94778656
81MP0003011_delayed_dark_adaptation0.94520578
82MP0001145_abnormal_male_reproductive0.94371680
83MP0002092_abnormal_eye_morphology0.93591760
84MP0000358_abnormal_cell_content/0.93162537
85MP0001853_heart_inflammation0.92437652
86MP0004808_abnormal_hematopoietic_stem0.91670438
87MP0002420_abnormal_adaptive_immunity0.90054577
88MP0001188_hyperpigmentation0.90049881
89MP0001819_abnormal_immune_cell0.89536906
90MP0001119_abnormal_female_reproductive0.89145798
91MP0002234_abnormal_pharynx_morphology0.88180154
92MP0003121_genomic_imprinting0.87822107
93MP0001346_abnormal_lacrimal_gland0.86760329
94MP0005266_abnormal_metabolism0.85171896
95MP0002796_impaired_skin_barrier0.84811393
96MP0008260_abnormal_autophagy0.84217540
97MP0002452_abnormal_antigen_presenting0.82440113
98MP0002160_abnormal_reproductive_system0.80722259
99MP0002938_white_spotting0.79907313
100MP0000371_diluted_coat_color0.79899779
101MP0000653_abnormal_sex_gland0.79495920
102MP0005076_abnormal_cell_differentiation0.78790676
103MP0002254_reproductive_system_inflammat0.78544430
104MP0005671_abnormal_response_to0.77130820
105MP0002723_abnormal_immune_serum0.76631038
106MP0005499_abnormal_olfactory_system0.76582782
107MP0005394_taste/olfaction_phenotype0.76582782
108MP0000579_abnormal_nail_morphology0.76127572
109MP0001915_intracranial_hemorrhage0.76016104
110MP0006035_abnormal_mitochondrial_morpho0.74603069
111MP0001929_abnormal_gametogenesis0.74400674
112MP0001790_abnormal_immune_system0.73870739
113MP0005387_immune_system_phenotype0.73870739
114MP0001764_abnormal_homeostasis0.72779952
115MP0005025_abnormal_response_to0.72685613
116MP0000751_myopathy0.72558146
117MP0003705_abnormal_hypodermis_morpholog0.71055224
118MP0002161_abnormal_fertility/fecundity0.69516540
119MP0009785_altered_susceptibility_to0.69403694
120MP0005451_abnormal_body_composition0.69213081
121MP0000534_abnormal_ureter_morphology0.69053577
122MP0001286_abnormal_eye_development0.68603058
123MP0002277_abnormal_respiratory_mucosa0.68104993
124MP0001348_abnormal_lacrimal_gland0.67985425
125MP0010307_abnormal_tumor_latency0.67943440
126MP0005408_hypopigmentation0.67399206
127MP0003119_abnormal_digestive_system0.67129561
128MP0005384_cellular_phenotype0.67099785
129MP0000566_synostosis0.66017167
130MP0000049_abnormal_middle_ear0.65680023
131MP0001873_stomach_inflammation0.65547065
132MP0003698_abnormal_male_reproductive0.65491726
133MP0002089_abnormal_postnatal_growth/wei0.65319568
134MP0003315_abnormal_perineum_morphology0.64817804
135MP0002233_abnormal_nose_morphology0.64663944
136MP0000750_abnormal_muscle_regeneration0.64607651
137MP0000858_altered_metastatic_potential0.64490358
138MP0005666_abnormal_adipose_tissue0.64382901
139MP0002405_respiratory_system_inflammati0.62897698
140MP0005389_reproductive_system_phenotype0.61535487
141MP0009278_abnormal_bone_marrow0.61228018

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.63938463
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.26726232
3Reticulocytopenia (HP:0001896)4.24327920
4Abnormality of cells of the erythroid lineage (HP:0012130)4.12076354
5Abnormal number of erythroid precursors (HP:0012131)4.11891793
6Chromsome breakage (HP:0040012)4.04474687
7Panhypogammaglobulinemia (HP:0003139)3.94286839
8Degeneration of anterior horn cells (HP:0002398)3.45492239
9Abnormality of the anterior horn cell (HP:0006802)3.45492239
10Abnormality of glycolysis (HP:0004366)3.34916063
11Oral leukoplakia (HP:0002745)3.33789867
12Carpal bone hypoplasia (HP:0001498)3.30653448
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.28391692
14Cerebral hypomyelination (HP:0006808)3.26841417
15Breast hypoplasia (HP:0003187)3.24738530
16Truncus arteriosus (HP:0001660)3.18492789
17Abnormality of pyrimidine metabolism (HP:0004353)3.18062548
18Selective tooth agenesis (HP:0001592)3.13034587
19Abnormality of the renal collecting system (HP:0004742)3.05606584
20Increased serum pyruvate (HP:0003542)3.04613314
21Aplastic anemia (HP:0001915)3.00347736
22Patellar aplasia (HP:0006443)2.95792871
23Absent thumb (HP:0009777)2.95716164
24Hepatocellular necrosis (HP:0001404)2.92758418
25Abnormality of the ileum (HP:0001549)2.91244292
26Absent radius (HP:0003974)2.88437089
27Meckel diverticulum (HP:0002245)2.87478508
28Abnormality of the preputium (HP:0100587)2.85895501
29Duplicated collecting system (HP:0000081)2.85615891
30Abnormal mitochondria in muscle tissue (HP:0008316)2.85320829
31Double outlet right ventricle (HP:0001719)2.83973488
32Congenital malformation of the right heart (HP:0011723)2.83973488
33Broad distal phalanx of finger (HP:0009836)2.76159815
34Recurrent viral infections (HP:0004429)2.75104752
35Aplasia/Hypoplasia of the patella (HP:0006498)2.73765803
36Hepatic necrosis (HP:0002605)2.68453225
37Macrocytic anemia (HP:0001972)2.68412337
38Pallor (HP:0000980)2.67502784
39Acute necrotizing encephalopathy (HP:0006965)2.66009035
40Poikiloderma (HP:0001029)2.65543386
41Aplasia involving forearm bones (HP:0009822)2.64917253
42Absent forearm bone (HP:0003953)2.64917253
43Acute encephalopathy (HP:0006846)2.62698245
44Abnormality of T cell physiology (HP:0011840)2.62627951
45Multiple enchondromatosis (HP:0005701)2.62052890
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.61379756
47Microretrognathia (HP:0000308)2.60577065
48Rough bone trabeculation (HP:0100670)2.58348501
49Abnormality of chromosome stability (HP:0003220)2.57990277
50Medulloblastoma (HP:0002885)2.52602771
51Increased CSF lactate (HP:0002490)2.51669893
52Abnormal number of incisors (HP:0011064)2.51278842
53Entropion (HP:0000621)2.49455904
54Impulsivity (HP:0100710)2.49361091
55Mitochondrial inheritance (HP:0001427)2.48337124
563-Methylglutaconic aciduria (HP:0003535)2.43522185
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.42720537
58Hyperacusis (HP:0010780)2.39062565
59Bone marrow hypocellularity (HP:0005528)2.38194971
60Type I transferrin isoform profile (HP:0003642)2.37977186
61Ragged-red muscle fibers (HP:0003200)2.37098170
62Myelodysplasia (HP:0002863)2.36808639
63Ependymoma (HP:0002888)2.36672315
64Villous atrophy (HP:0011473)2.36226825
65Abnormality of small intestinal villus morphology (HP:0011472)2.36226825
66Agnosia (HP:0010524)2.35335481
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34260451
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34260451
69Optic nerve coloboma (HP:0000588)2.34159417
70Agammaglobulinemia (HP:0004432)2.34143190
71Increased serum lactate (HP:0002151)2.31635242
72Cholecystitis (HP:0001082)2.31171486
73Abnormal gallbladder physiology (HP:0012438)2.31171486
74Recurrent cutaneous fungal infections (HP:0011370)2.30746689
75Chronic mucocutaneous candidiasis (HP:0002728)2.30746689
76Colitis (HP:0002583)2.30182391
77Atrophy/Degeneration involving motor neurons (HP:0007373)2.29757363
78Colon cancer (HP:0003003)2.29262576
79Lactic acidosis (HP:0003128)2.28183422
80Horseshoe kidney (HP:0000085)2.25572027
81Cellular immunodeficiency (HP:0005374)2.24935069
82Squamous cell carcinoma (HP:0002860)2.22985971
83Abnormality of the aortic arch (HP:0012303)2.22582381
84Premature graying of hair (HP:0002216)2.20551300
85Abnormality of DNA repair (HP:0003254)2.19624580
86Respiratory difficulties (HP:0002880)2.17084459
87Increased nuchal translucency (HP:0010880)2.16194397
88Rectovaginal fistula (HP:0000143)2.16170989
89Rectal fistula (HP:0100590)2.16170989
90Duodenal stenosis (HP:0100867)2.14328440
91Small intestinal stenosis (HP:0012848)2.14328440
92Hypoplasia of the capital femoral epiphysis (HP:0003090)2.14070968
93Cerebral edema (HP:0002181)2.12199141
94Abnormal lung lobation (HP:0002101)2.09081492
95Pancytopenia (HP:0001876)2.08969984
96Transposition of the great arteries (HP:0001669)2.08576382
97Abnormal connection of the cardiac segments (HP:0011545)2.08576382
98Abnormal ventriculo-arterial connection (HP:0011563)2.08576382
99Bell-shaped thorax (HP:0001591)2.07796362
100Occipital encephalocele (HP:0002085)2.06790058
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06505118
102Abnormality of T cells (HP:0002843)2.06010067
103Exercise intolerance (HP:0003546)2.05118629
104Poor suck (HP:0002033)2.04508104
105Triphalangeal thumb (HP:0001199)2.04399477
106Testicular atrophy (HP:0000029)2.04359307
107Sloping forehead (HP:0000340)2.03474799
108Tracheoesophageal fistula (HP:0002575)2.02924139
109Increased intramyocellular lipid droplets (HP:0012240)2.01699384
110Absent epiphyses (HP:0010577)2.00717830
111Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.00717830
112Abnormal pancreas size (HP:0012094)2.00217849
113Cortical dysplasia (HP:0002539)1.99761685
114Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98297868
115Abnormality of the umbilical cord (HP:0010881)1.95363255
116Encephalitis (HP:0002383)1.95298038
117Clubbing of toes (HP:0100760)1.95207444
118Intestinal fistula (HP:0100819)1.94426461
119Vaginal fistula (HP:0004320)1.91924911
120Abnormality of the heme biosynthetic pathway (HP:0010472)1.91453805
121Abnormality of reticulocytes (HP:0004312)1.90609962
122Abnormality of the duodenum (HP:0002246)1.89944938
123Microvesicular hepatic steatosis (HP:0001414)1.88219068
12411 pairs of ribs (HP:0000878)1.88154944
125Cerebellar hypoplasia (HP:0001321)1.87951842
126Thrombocytosis (HP:0001894)1.87641721
127Trismus (HP:0000211)1.87049741
128Long palpebral fissure (HP:0000637)1.86243996
129Retinal dysplasia (HP:0007973)1.86197803
130Ectopic kidney (HP:0000086)1.85878468
131Reduced antithrombin III activity (HP:0001976)1.85503816
132Secondary amenorrhea (HP:0000869)1.85204605
133Spastic diplegia (HP:0001264)1.84744218
134Premature ovarian failure (HP:0008209)1.84432683
135Increased muscle lipid content (HP:0009058)1.84196426
136Abnormality of abdominal situs (HP:0011620)1.83865239
137Abdominal situs inversus (HP:0003363)1.83865239
138Basal cell carcinoma (HP:0002671)1.83807012
139Hyperthyroidism (HP:0000836)1.83591640
140Abnormal trabecular bone morphology (HP:0100671)1.82167671
141Progressive muscle weakness (HP:0003323)1.81986234
142Lymphoma (HP:0002665)1.81689212
143Abnormality of the labia minora (HP:0012880)1.80859237
144Megaloblastic anemia (HP:0001889)1.80233500
145IgM deficiency (HP:0002850)1.79892477
146Insomnia (HP:0100785)1.79179397
147Cleft eyelid (HP:0000625)1.78928993
148Generalized hypotonia (HP:0001290)1.78456678
149Amaurosis fugax (HP:0100576)1.77647208
150Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77612530
151Hyperalaninemia (HP:0003348)1.77612530
152Tetralogy of Fallot (HP:0001636)1.76659551
153Myopathic facies (HP:0002058)1.76619638
154Overriding aorta (HP:0002623)1.74374336
155Increased hepatocellular lipid droplets (HP:0006565)1.73866854
156High anterior hairline (HP:0009890)1.73701410
157Anophthalmia (HP:0000528)1.73109434
158Hypoplasia of the pons (HP:0012110)1.72857142
159Abnormality of the fetal cardiovascular system (HP:0010948)1.69953770
160Abnormal umbilical cord blood vessels (HP:0011403)1.69953770
161Single umbilical artery (HP:0001195)1.69953770
162Cholelithiasis (HP:0001081)1.69046478
163Progressive external ophthalmoplegia (HP:0000590)1.68597960
164Proximal placement of thumb (HP:0009623)1.67195702
165Reticulocytosis (HP:0001923)1.66558199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.69262568
2VRK24.12606531
3SMG13.88962446
4TRIB33.59971068
5WEE13.41143054
6CDC73.21536486
7NME22.70254496
8TAOK22.57191183
9TSSK62.52199614
10STK162.37808471
11TESK22.35042212
12SRPK12.29303074
13EIF2AK12.26262693
14MKNK12.12236639
15ACVR1B1.94105872
16NEK21.93122047
17MKNK21.90648195
18BCKDK1.87836283
19MAP3K101.87679905
20PASK1.82338985
21SIK11.77092706
22ATR1.76162952
23NEK11.75006482
24CDK71.73672841
25TTK1.71714276
26TAF11.70831535
27VRK11.70752237
28MAP4K11.68944763
29PLK11.68879628
30PLK41.63189867
31TAOK31.55824506
32MST41.54321195
33SCYL21.51905035
34TLK11.51757625
35CDK81.48152141
36PIM21.47700090
37EIF2AK31.47226496
38DYRK31.42111177
39PBK1.36933467
40BRSK21.29489946
41CDC42BPA1.25907051
42CDK121.25842760
43PIM11.24210097
44ICK1.19256136
45RPS6KB21.19094728
46STK41.17159226
47AURKA1.17138170
48MAP3K81.16568889
49AURKB1.15631659
50ZAK1.13727819
51CHEK21.13170386
52RPS6KA41.11033556
53MAP3K111.10393323
54KDR1.10176941
55BRD41.07295205
56PLK31.06360447
57STK101.05264097
58EPHA21.01014595
59CHEK10.94703987
60CDK40.94319872
61BRSK10.91563586
62FLT30.90540593
63PAK40.88715326
64IRAK40.88123268
65PKN20.87564903
66ARAF0.83333271
67ZAP700.82355484
68YES10.81307416
69TGFBR10.77703145
70CDK90.77355480
71CSNK1G30.76654260
72KIT0.76386909
73CDK20.75858804
74IRAK30.75267884
75CCNB10.74397711
76IKBKB0.73623560
77CSNK2A20.73531180
78PRKD30.71314686
79ILK0.71054803
80BLK0.69869495
81NLK0.69762947
82DAPK10.69550000
83MAPK110.69052610
84ATM0.68258596
85CSNK2A10.67523207
86NUAK10.66152623
87CLK10.62795573
88SIK30.62125631
89MAP3K50.61822974
90CHUK0.60526887
91TESK10.60206885
92AKT20.60064826
93MST1R0.59702888
94MUSK0.58268280
95MAP2K60.55810555
96ABL20.55451929
97MAP2K30.55254422
98BTK0.55086706
99AKT30.54426299
100CAMK1D0.54393364
101CDK190.53459784
102CDK10.53333757
103CSNK1G20.52341066
104LRRK20.50773884
105MTOR0.49457569
106CSNK1G10.49083094
107PDK20.48354938
108EIF2AK20.48281815
109CDK11A0.48163568
110CSNK1A1L0.48149338
111GRK60.47836495
112JAK30.47324841
113MAP3K90.46959947
114CDK150.46030117
115PRPF4B0.45775096
116RPS6KA50.42323119
117PAK10.42299263
118CDK180.42214002
119PTK60.41142083
120PRKDC0.41075498
121CDK140.41031321
122MELK0.38724176
123NME10.38259109
124TEC0.38122554
125PRKCI0.38096322
126CSF1R0.37939094
127DYRK20.37455037
128MAP3K140.37327192
129RPS6KA60.37064983
130RPS6KA10.36801767
131ALK0.35446530
132EEF2K0.35069762
133BRAF0.34497972
134MAP2K20.34167425
135TYK20.33802281
136STK38L0.33313048
137MARK30.33160922
138IKBKE0.33122488
139RPS6KC10.32815749

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.75642129
2Mismatch repair_Homo sapiens_hsa034303.96253236
3RNA polymerase_Homo sapiens_hsa030203.78799350
4Proteasome_Homo sapiens_hsa030503.68174850
5Ribosome_Homo sapiens_hsa030103.63384779
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54929274
7Spliceosome_Homo sapiens_hsa030403.31440877
8Base excision repair_Homo sapiens_hsa034103.04968920
9Homologous recombination_Homo sapiens_hsa034402.84522699
10RNA transport_Homo sapiens_hsa030132.65545266
11Pyrimidine metabolism_Homo sapiens_hsa002402.64210253
12One carbon pool by folate_Homo sapiens_hsa006702.57763719
13Nucleotide excision repair_Homo sapiens_hsa034202.56993295
14* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43890618
15Fanconi anemia pathway_Homo sapiens_hsa034602.21485011
16Cell cycle_Homo sapiens_hsa041102.11872641
17RNA degradation_Homo sapiens_hsa030181.85430507
18Basal transcription factors_Homo sapiens_hsa030221.83900969
19Non-homologous end-joining_Homo sapiens_hsa034501.81461716
20Fatty acid elongation_Homo sapiens_hsa000621.63257035
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48723588
22Primary immunodeficiency_Homo sapiens_hsa053401.40835780
23mRNA surveillance pathway_Homo sapiens_hsa030151.38526775
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34862948
25Purine metabolism_Homo sapiens_hsa002301.31969539
26Antigen processing and presentation_Homo sapiens_hsa046121.27291194
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.25265862
28p53 signaling pathway_Homo sapiens_hsa041151.23311687
29Biosynthesis of amino acids_Homo sapiens_hsa012301.16165519
30Epstein-Barr virus infection_Homo sapiens_hsa051691.12891267
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07767721
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05080159
33Folate biosynthesis_Homo sapiens_hsa007901.04192014
34Selenocompound metabolism_Homo sapiens_hsa004501.01224967
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99976116
36Alzheimers disease_Homo sapiens_hsa050100.98210216
37Vitamin B6 metabolism_Homo sapiens_hsa007500.97041605
38Sulfur relay system_Homo sapiens_hsa041220.96802585
39Pentose phosphate pathway_Homo sapiens_hsa000300.95624889
40Fatty acid metabolism_Homo sapiens_hsa012120.93588655
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.93103989
42Steroid biosynthesis_Homo sapiens_hsa001000.92502142
43Herpes simplex infection_Homo sapiens_hsa051680.90874472
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.85401478
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.84955724
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84496704
47Huntingtons disease_Homo sapiens_hsa050160.83447734
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83244521
49Carbon metabolism_Homo sapiens_hsa012000.76783661
50Parkinsons disease_Homo sapiens_hsa050120.73355647
51Fructose and mannose metabolism_Homo sapiens_hsa000510.68538388
52Systemic lupus erythematosus_Homo sapiens_hsa053220.65713248
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64627905
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64111965
55Viral carcinogenesis_Homo sapiens_hsa052030.63367330
56Oxidative phosphorylation_Homo sapiens_hsa001900.62898451
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62275003
58Arginine and proline metabolism_Homo sapiens_hsa003300.55362959
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55324898
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54251888
61Cardiac muscle contraction_Homo sapiens_hsa042600.53849890
62Glutathione metabolism_Homo sapiens_hsa004800.53592629
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53419285
64Propanoate metabolism_Homo sapiens_hsa006400.52292320
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50361475
66Alcoholism_Homo sapiens_hsa050340.49173074
67Tryptophan metabolism_Homo sapiens_hsa003800.48910104
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48699867
69HTLV-I infection_Homo sapiens_hsa051660.48633162
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46632995
71Protein export_Homo sapiens_hsa030600.46169167
72Legionellosis_Homo sapiens_hsa051340.46067662
73Fatty acid degradation_Homo sapiens_hsa000710.45989483
74Metabolic pathways_Homo sapiens_hsa011000.45812015
75Arginine biosynthesis_Homo sapiens_hsa002200.44366661
76Fatty acid biosynthesis_Homo sapiens_hsa000610.41701072
77Thyroid cancer_Homo sapiens_hsa052160.40904060
78Galactose metabolism_Homo sapiens_hsa000520.40075305
79Bladder cancer_Homo sapiens_hsa052190.39844631
80Influenza A_Homo sapiens_hsa051640.37915572
81Measles_Homo sapiens_hsa051620.37108911
82Butanoate metabolism_Homo sapiens_hsa006500.36252947
83Notch signaling pathway_Homo sapiens_hsa043300.35827877
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35434286
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.35207572
86Vibrio cholerae infection_Homo sapiens_hsa051100.32976377
87Apoptosis_Homo sapiens_hsa042100.32486064
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31868932
89Phenylalanine metabolism_Homo sapiens_hsa003600.31067761
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30778530
91Peroxisome_Homo sapiens_hsa041460.29546551
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.29101695
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28962571
94Shigellosis_Homo sapiens_hsa051310.27858719
95Colorectal cancer_Homo sapiens_hsa052100.27292697
96Oocyte meiosis_Homo sapiens_hsa041140.26589232
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26068044
98Hippo signaling pathway_Homo sapiens_hsa043900.25625270
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23957072
100Sulfur metabolism_Homo sapiens_hsa009200.23218382
101Regulation of autophagy_Homo sapiens_hsa041400.22143570
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21584212
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21392795
104Chronic myeloid leukemia_Homo sapiens_hsa052200.21086730
105N-Glycan biosynthesis_Homo sapiens_hsa005100.20454937
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20172023
107Hematopoietic cell lineage_Homo sapiens_hsa046400.19411278
108Acute myeloid leukemia_Homo sapiens_hsa052210.19283935
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18496852
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18270714
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15872653
112Basal cell carcinoma_Homo sapiens_hsa052170.15707566
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15487076
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.14883876
115Hedgehog signaling pathway_Homo sapiens_hsa043400.14741140
116Insulin signaling pathway_Homo sapiens_hsa049100.13696766
117Pyruvate metabolism_Homo sapiens_hsa006200.13596821
118Non-small cell lung cancer_Homo sapiens_hsa052230.13357582
119Glucagon signaling pathway_Homo sapiens_hsa049220.13149782
120beta-Alanine metabolism_Homo sapiens_hsa004100.13060699
121Graft-versus-host disease_Homo sapiens_hsa053320.12699163
122Lysine degradation_Homo sapiens_hsa003100.11342488
123Small cell lung cancer_Homo sapiens_hsa052220.11087090
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09718866
125MicroRNAs in cancer_Homo sapiens_hsa052060.09082374
126Vitamin digestion and absorption_Homo sapiens_hsa049770.09013192
127Arachidonic acid metabolism_Homo sapiens_hsa005900.08969773

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