SART1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.77041187
2DNA unwinding involved in DNA replication (GO:0006268)4.57947554
3viral transcription (GO:0019083)4.17754036
4translational termination (GO:0006415)4.00071223
5negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.97523486
6regulation of translational fidelity (GO:0006450)3.96253022
7heterochromatin organization (GO:0070828)3.96076451
8protein localization to kinetochore (GO:0034501)3.91980323
9pre-miRNA processing (GO:0031054)3.67990105
10nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.64694125
11translational elongation (GO:0006414)3.64617009
12dosage compensation (GO:0007549)3.62901801
13folic acid-containing compound biosynthetic process (GO:0009396)3.62754998
14negative regulation of RNA splicing (GO:0033119)3.61268713
15nuclear pore complex assembly (GO:0051292)3.50147748
16translational initiation (GO:0006413)3.48432517
17mRNA stabilization (GO:0048255)3.47846594
18RNA stabilization (GO:0043489)3.47846594
19nuclear pore organization (GO:0006999)3.46830130
20protein localization to endosome (GO:0036010)3.46021818
21regulation of posttranscriptional gene silencing (GO:0060147)3.45549028
22regulation of gene silencing by miRNA (GO:0060964)3.45549028
23regulation of gene silencing by RNA (GO:0060966)3.45549028
243-UTR-mediated mRNA stabilization (GO:0070935)3.42231908
25formation of translation preinitiation complex (GO:0001731)3.41848801
26protein localization to chromosome, centromeric region (GO:0071459)3.38108079
27DNA duplex unwinding (GO:0032508)3.36501066
28ribosomal small subunit assembly (GO:0000028)3.36043064
29negative regulation of mRNA processing (GO:0050686)3.34642377
30modulation by symbiont of host cellular process (GO:0044068)3.34550591
31response to peptidoglycan (GO:0032494)3.32517442
32response to muramyl dipeptide (GO:0032495)3.32155209
33DNA geometric change (GO:0032392)3.32048767
34mitotic nuclear envelope disassembly (GO:0007077)3.31388816
35DNA strand elongation involved in DNA replication (GO:0006271)3.27698480
36positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.26662578
37negative regulation of mRNA metabolic process (GO:1903312)3.25328142
38Golgi transport vesicle coating (GO:0048200)3.24104341
39COPI coating of Golgi vesicle (GO:0048205)3.24104341
40maturation of SSU-rRNA (GO:0030490)3.24014612
41NIK/NF-kappaB signaling (GO:0038061)3.23945585
42chromatin assembly (GO:0031497)3.21903684
43regulation of translational termination (GO:0006449)3.20268712
44ribosomal small subunit biogenesis (GO:0042274)3.19650458
45pentose-phosphate shunt (GO:0006098)3.19634385
46regulation of gamma-delta T cell differentiation (GO:0045586)3.18585425
47modulation by virus of host process (GO:0019054)3.18049996
48negative regulation of histone methylation (GO:0031061)3.16592598
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.15209894
50positive regulation by organism of defense response of other organism involved in symbiotic interact3.15209894
51modulation by symbiont of host immune response (GO:0052553)3.15209894
52positive regulation by symbiont of host defense response (GO:0052509)3.15209894
53modulation by symbiont of host defense response (GO:0052031)3.15209894
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.15209894
55mitotic G1 DNA damage checkpoint (GO:0031571)3.14682938
56viral life cycle (GO:0019058)3.12963832
57regulation of early endosome to late endosome transport (GO:2000641)3.11494711
58cellular protein complex disassembly (GO:0043624)3.10225271
59membrane disassembly (GO:0030397)3.09807190
60nuclear envelope disassembly (GO:0051081)3.09807190
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.09428472
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.09428472
63ncRNA 3-end processing (GO:0043628)3.07885608
64maternal placenta development (GO:0001893)3.07211740
65protein complex disassembly (GO:0043241)3.06927794
66peptidyl-lysine dimethylation (GO:0018027)3.06201823
67DNA strand elongation (GO:0022616)3.05971441
68pinocytosis (GO:0006907)3.05824932
69peptidyl-arginine omega-N-methylation (GO:0035247)3.05781298
70positive regulation of Cdc42 GTPase activity (GO:0043089)3.02709494
71mannose metabolic process (GO:0006013)3.02572272
72regulation of mammary gland epithelial cell proliferation (GO:0033599)2.99495688
73positive thymic T cell selection (GO:0045059)2.98695899
74mitotic sister chromatid segregation (GO:0000070)2.97781657
75IMP biosynthetic process (GO:0006188)2.96575493
76sister chromatid segregation (GO:0000819)2.96515946
77spliceosomal tri-snRNP complex assembly (GO:0000244)2.95428622
78regulation of RNA export from nucleus (GO:0046831)2.94857644
79alternative mRNA splicing, via spliceosome (GO:0000380)2.94333898
80regulation of type I interferon-mediated signaling pathway (GO:0060338)2.94134022
81trophectodermal cell differentiation (GO:0001829)2.94126368
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.93555411
83response to laminar fluid shear stress (GO:0034616)2.91875550
84positive regulation of histone deacetylation (GO:0031065)2.91447140
85intracellular estrogen receptor signaling pathway (GO:0030520)2.89978168
86negative regulation of cell size (GO:0045792)2.89969845
87barbed-end actin filament capping (GO:0051016)2.88447439
88DNA replication initiation (GO:0006270)2.87418319
89cellular response to virus (GO:0098586)2.86030526
90protein targeting to ER (GO:0045047)2.85606074
91activation of Rac GTPase activity (GO:0032863)2.83893699
92positive regulation of gamma-delta T cell activation (GO:0046645)2.83828886
93negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.83158667
94negative regulation of cell killing (GO:0031342)2.83158667
95regulation of histone H3-K9 methylation (GO:0051570)2.81755808
96macromolecular complex disassembly (GO:0032984)2.80921522
97cotranslational protein targeting to membrane (GO:0006613)2.78773728
98telomere maintenance via semi-conservative replication (GO:0032201)2.78701069
99nuclear-transcribed mRNA catabolic process (GO:0000956)2.76874139
100ribosomal large subunit biogenesis (GO:0042273)2.76736881
101thymic T cell selection (GO:0045061)2.75317195
102DNA replication-dependent nucleosome organization (GO:0034723)2.73749889
103DNA replication-dependent nucleosome assembly (GO:0006335)2.73749889
104establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73234427
105regulation of gamma-delta T cell activation (GO:0046643)2.72501970
106regulation of mRNA stability (GO:0043488)2.72410816
107regulation of histone H3-K27 methylation (GO:0061085)2.71827707
108antigen processing and presentation of endogenous antigen (GO:0019883)2.71399864
109mitotic G1/S transition checkpoint (GO:0044819)2.71137387
110negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.71044245
111negative regulation of gene expression, epigenetic (GO:0045814)2.70847972
112regulation of sister chromatid cohesion (GO:0007063)2.70736080
113mitotic chromosome condensation (GO:0007076)2.69829779
114cell-substrate adherens junction assembly (GO:0007045)2.69770829
115focal adhesion assembly (GO:0048041)2.69770829
116regulation of leukocyte degranulation (GO:0043300)2.69252358
117mitotic sister chromatid cohesion (GO:0007064)2.69075128
118RNA catabolic process (GO:0006401)2.69015485
119embryonic process involved in female pregnancy (GO:0060136)2.68673658
120nuclear envelope organization (GO:0006998)2.68100171
121regulation of superoxide anion generation (GO:0032928)2.68016312
122establishment of apical/basal cell polarity (GO:0035089)2.67607036
123apoptotic process involved in morphogenesis (GO:0060561)2.66744708
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66296492
125regulation of glucose import in response to insulin stimulus (GO:2001273)2.65125925
126* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.65080093
127* mRNA splicing, via spliceosome (GO:0000398)2.65080093
128glucose catabolic process (GO:0006007)2.65056100
129peptidyl-arginine N-methylation (GO:0035246)2.65021934
130peptidyl-arginine methylation (GO:0018216)2.65021934
131negative regulation of necroptotic process (GO:0060546)2.64673612
132nucleosome disassembly (GO:0006337)2.64586755
133protein-DNA complex disassembly (GO:0032986)2.64586755
134positive regulation of chromosome segregation (GO:0051984)2.64075871
135lipopolysaccharide-mediated signaling pathway (GO:0031663)2.64070455
136mRNA catabolic process (GO:0006402)2.64003827
137adherens junction assembly (GO:0034333)2.63556689
138* RNA splicing, via transesterification reactions (GO:0000375)2.62034324
139NADPH regeneration (GO:0006740)2.61859701
140histone H2A monoubiquitination (GO:0035518)2.61752183
141chromatin silencing (GO:0006342)2.61259939
142stress fiber assembly (GO:0043149)2.60658363
143DNA conformation change (GO:0071103)2.59954300
144G1 DNA damage checkpoint (GO:0044783)2.59690284
145ribonucleoprotein complex biogenesis (GO:0022613)2.59430542
146IMP metabolic process (GO:0046040)2.59258599
147leukocyte aggregation (GO:0070486)2.54858076
148activation of MAPKKK activity (GO:0000185)2.52742623
149retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.50575525
150regulation of necroptotic process (GO:0060544)2.49898507
151detection of bacterium (GO:0016045)2.48638449
152detection of other organism (GO:0098543)2.45011537
153regulation of myeloid leukocyte mediated immunity (GO:0002886)2.44125072
154regulation of nucleobase-containing compound transport (GO:0032239)2.42705547
155regulation of NFAT protein import into nucleus (GO:0051532)2.42344738
156regulation of defense response to virus by virus (GO:0050690)2.41169343
157negative regulation of viral release from host cell (GO:1902187)2.39767686
158regulation of mast cell degranulation (GO:0043304)2.39097866
159cellular hyperosmotic response (GO:0071474)2.39095182
160response to host (GO:0075136)2.37708007
161response to host defenses (GO:0052200)2.37708007
162response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.37708007
163negative regulation of phagocytosis (GO:0050765)2.35999284
164cellular response to interleukin-4 (GO:0071353)2.35560087
165germinal center formation (GO:0002467)2.35458863
166proline biosynthetic process (GO:0006561)2.33016094
167modulation by virus of host morphology or physiology (GO:0019048)2.32912531
168macrophage activation involved in immune response (GO:0002281)2.32663454
169positive regulation of blood vessel endothelial cell migration (GO:0043536)2.31558569
170maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.31071768
171protein retention in ER lumen (GO:0006621)2.30011798
172antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.27034888
173regulation of necrotic cell death (GO:0010939)2.26526344
174regulation of extracellular matrix disassembly (GO:0010715)2.25495251
175regulation of chromatin binding (GO:0035561)2.24963507
176positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.24828380
177activation of JUN kinase activity (GO:0007257)2.24030757
178glucose 6-phosphate metabolic process (GO:0051156)2.23732094
179cell-substrate junction assembly (GO:0007044)2.22802477
180positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.21984645
181activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.21645677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.71774273
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.92939888
3MYC_22102868_ChIP-Seq_BL_Human3.55139625
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23520625
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.03671146
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.86187724
7VDR_21846776_ChIP-Seq_THP-1_Human2.67410537
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.57507891
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35017231
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33216268
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25198074
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08695595
13* TCF7_22412390_ChIP-Seq_EML_Mouse1.98307218
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95226783
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90171442
16KDM2B_26808549_Chip-Seq_DND41_Human1.86374514
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83483517
18CIITA_25753668_ChIP-Seq_RAJI_Human1.77892871
19XRN2_22483619_ChIP-Seq_HELA_Human1.77591004
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76051826
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.73850710
22MAF_26560356_Chip-Seq_TH1_Human1.72096344
23* UTX_26944678_Chip-Seq_JUKART_Human1.71833090
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70575601
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64398546
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62782571
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62664777
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60996782
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60580468
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59105752
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55805611
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.54481479
33ZNF263_19887448_ChIP-Seq_K562_Human1.49398006
34* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48235719
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46589926
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45427577
37* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44398945
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43379900
39KDM2B_26808549_Chip-Seq_K562_Human1.43212809
40LXR_22292898_ChIP-Seq_THP-1_Human1.42507787
41KDM5A_27292631_Chip-Seq_BREAST_Human1.38753445
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.37506125
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36529297
44VDR_24763502_ChIP-Seq_THP-1_Human1.35061961
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33013214
46* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32226245
47AR_21909140_ChIP-Seq_LNCAP_Human1.31403555
48MAF_26560356_Chip-Seq_TH2_Human1.30989647
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30474389
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.29079004
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27498976
52CLOCK_20551151_ChIP-Seq_293T_Human1.27372558
53* ETS1_20019798_ChIP-Seq_JURKAT_Human1.27286872
54* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26035621
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25822365
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24011107
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23583895
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23181437
59MYB_26560356_Chip-Seq_TH1_Human1.22798382
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22448243
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22319485
62* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21231090
63ATF3_27146783_Chip-Seq_COLON_Human1.21072587
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20438867
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20210767
66* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20076154
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19555067
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19543893
69* NCOR1_26117541_ChIP-Seq_K562_Human1.19187911
70RACK7_27058665_Chip-Seq_MCF-7_Human1.18793320
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.18698789
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18533519
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18503483
74* RUNX1_22412390_ChIP-Seq_EML_Mouse1.17626367
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17616593
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17253783
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15765417
78MYB_26560356_Chip-Seq_TH2_Human1.15530473
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14955652
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.14786300
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.14631337
82* GABP_19822575_ChIP-Seq_HepG2_Human1.12899408
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12844010
84SMC4_20622854_ChIP-Seq_HELA_Human1.12707140
85TTF2_22483619_ChIP-Seq_HELA_Human1.12561558
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11751420
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.11682130
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.11506677
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11394771
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11052267
91SCL_19346495_ChIP-Seq_HPC-7_Human1.10701011
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10214126
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09785821
94SPI1_23127762_ChIP-Seq_K562_Human1.09687808
95BP1_19119308_ChIP-ChIP_Hs578T_Human1.09132326
96TFEB_21752829_ChIP-Seq_HELA_Human1.08609358
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08218744
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07833266
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07224593
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07029841
101CREB1_26743006_Chip-Seq_LNCaP_Human1.06929121
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06568907
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05996833
104FOXP3_21729870_ChIP-Seq_TREG_Human1.05848924
105* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05123336
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.04898664
107ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03237439
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03108671
109CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02639788
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02579631
111MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02409505
112BCOR_27268052_Chip-Seq_Bcells_Human1.02363234
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01474907
114* VDR_23849224_ChIP-Seq_CD4+_Human1.00143316
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99876215
116P68_20966046_ChIP-Seq_HELA_Human0.99848339
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99672198
118* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99254302
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99252299
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98179237
121SPI1_23547873_ChIP-Seq_NB4_Human0.97965416
122* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96327209
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.95484174
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93921849
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93539486
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93520686
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.92219956
128E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91815212
129DCP1A_22483619_ChIP-Seq_HELA_Human0.91522502
130FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91397395
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90897599
132CHD1_26751641_Chip-Seq_LNCaP_Human0.90537068
133CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89705732
134ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89254392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.31970328
2MP0010352_gastrointestinal_tract_polyps3.22895519
3MP0003693_abnormal_embryo_hatching3.16847662
4MP0003111_abnormal_nucleus_morphology2.97927308
5MP0004957_abnormal_blastocyst_morpholog2.90830875
6MP0005058_abnormal_lysosome_morphology2.90727546
7MP0003705_abnormal_hypodermis_morpholog2.83841803
8MP0005076_abnormal_cell_differentiation2.70033065
9MP0009278_abnormal_bone_marrow2.62615428
10MP0010094_abnormal_chromosome_stability2.60425566
11MP0003077_abnormal_cell_cycle2.55119622
12MP0002396_abnormal_hematopoietic_system2.42334886
13MP0008260_abnormal_autophagy2.35620338
14MP0003303_peritoneal_inflammation2.22684657
15MP0003300_gastrointestinal_ulcer2.12022388
16MP0008057_abnormal_DNA_replication2.05831390
17MP0001730_embryonic_growth_arrest2.05473052
18MP0003763_abnormal_thymus_physiology1.96949581
19MP0004808_abnormal_hematopoietic_stem1.93434748
20MP0003191_abnormal_cellular_cholesterol1.93322536
21MP0000350_abnormal_cell_proliferation1.92270720
22MP0010307_abnormal_tumor_latency1.85595064
23MP0003172_abnormal_lysosome_physiology1.83877304
24MP0000685_abnormal_immune_system1.77835547
25MP0003566_abnormal_cell_adhesion1.75572019
26MP0005397_hematopoietic_system_phenotyp1.74695137
27MP0001545_abnormal_hematopoietic_system1.74695137
28MP0008007_abnormal_cellular_replicative1.67927728
29MP0004858_abnormal_nervous_system1.67212168
30MP0000703_abnormal_thymus_morphology1.65664210
31MP0004197_abnormal_fetal_growth/weight/1.64541439
32MP0002398_abnormal_bone_marrow1.64113241
33MP0001672_abnormal_embryogenesis/_devel1.62662816
34MP0005380_embryogenesis_phenotype1.62662816
35MP0002419_abnormal_innate_immunity1.59279270
36MP0002086_abnormal_extraembryonic_tissu1.56902865
37MP0003984_embryonic_growth_retardation1.56375071
38MP0000490_abnormal_crypts_of1.55013271
39MP0002088_abnormal_embryonic_growth/wei1.54769315
40MP0005025_abnormal_response_to1.54533135
41MP0002084_abnormal_developmental_patter1.49733869
42MP0001697_abnormal_embryo_size1.48135591
43MP0002080_prenatal_lethality1.47771558
44MP0005464_abnormal_platelet_physiology1.43646871
45MP0002019_abnormal_tumor_incidence1.42974089
46MP0002085_abnormal_embryonic_tissue1.41978509
47MP0002722_abnormal_immune_system1.41767892
48MP0009333_abnormal_splenocyte_physiolog1.41259456
49MP0008438_abnormal_cutaneous_collagen1.38904365
50MP0002796_impaired_skin_barrier1.35986058
51MP0005023_abnormal_wound_healing1.34775260
52MP0000689_abnormal_spleen_morphology1.34320237
53MP0005666_abnormal_adipose_tissue1.33057052
54MP0002166_altered_tumor_susceptibility1.32534284
55MP0002877_abnormal_melanocyte_morpholog1.31716859
56MP0001800_abnormal_humoral_immune1.30830319
57MP0000733_abnormal_muscle_development1.29671705
58MP0003123_paternal_imprinting1.24750879
59MP0000313_abnormal_cell_death1.24088081
60MP0001849_ear_inflammation1.23108080
61MP0008961_abnormal_basal_metabolism1.23097580
62MP0004185_abnormal_adipocyte_glucose1.22903894
63MP0003436_decreased_susceptibility_to1.22614391
64MP0001853_heart_inflammation1.22373200
65MP0001348_abnormal_lacrimal_gland1.21083194
66MP0002429_abnormal_blood_cell1.19587090
67MP0000716_abnormal_immune_system1.18899715
68MP0008932_abnormal_embryonic_tissue1.18285780
69MP0001533_abnormal_skeleton_physiology1.17927911
70MP0010030_abnormal_orbit_morphology1.17452483
71MP0002148_abnormal_hypersensitivity_rea1.14659253
72MP0002405_respiratory_system_inflammati1.14436814
73MP0010155_abnormal_intestine_physiology1.14411219
74MP0002998_abnormal_bone_remodeling1.12557830
75MP0001915_intracranial_hemorrhage1.10931189
76MP0004233_abnormal_muscle_weight1.08791317
77MP0002420_abnormal_adaptive_immunity1.08221604
78MP0000858_altered_metastatic_potential1.07455767
79MP0005375_adipose_tissue_phenotype1.07308949
80MP0008058_abnormal_DNA_repair1.07161708
81MP0002452_abnormal_antigen_presenting1.06537810
82MP0001819_abnormal_immune_cell1.06031444
83MP0004381_abnormal_hair_follicle1.06014877
84MP0003567_abnormal_fetal_cardiomyocyte1.03347880
85MP0000678_abnormal_parathyroid_gland1.02787503
86MP0009053_abnormal_anal_canal1.02401894
87MP0003221_abnormal_cardiomyocyte_apopto1.01856366
88MP0003828_pulmonary_edema1.01579928
89MP0003786_premature_aging0.99876813
90MP0003075_altered_response_to0.99328828
91MP0002089_abnormal_postnatal_growth/wei0.99312542
92MP0003329_amyloid_beta_deposits0.99137060
93MP0001873_stomach_inflammation0.98735781
94MP0002060_abnormal_skin_morphology0.98664087
95MP0003866_abnormal_defecation0.98319520
96MP0002006_tumorigenesis0.95984583
97MP0004947_skin_inflammation0.95786594
98MP0003119_abnormal_digestive_system0.95785349
99MP0003115_abnormal_respiratory_system0.95290995
100MP0001790_abnormal_immune_system0.94988025
101MP0005387_immune_system_phenotype0.94988025
102MP0003724_increased_susceptibility_to0.94734970
103MP0002653_abnormal_ependyma_morphology0.94447602
104MP0002723_abnormal_immune_serum0.93861602
105MP0009785_altered_susceptibility_to0.92758425
106MP0005409_darkened_coat_color0.92107887
107MP0004510_myositis0.92005335
108MP0001835_abnormal_antigen_presentation0.91737852
109MP0000477_abnormal_intestine_morphology0.91601120
110MP0003279_aneurysm0.91116110
111MP0003453_abnormal_keratinocyte_physiol0.90735422
112MP0009672_abnormal_birth_weight0.90420082
113MP0010630_abnormal_cardiac_muscle0.89348735
114MP0009931_abnormal_skin_appearance0.88513017
115MP0008770_decreased_survivor_rate0.88326985
116MP0008877_abnormal_DNA_methylation0.88158834
117MP0005310_abnormal_salivary_gland0.87791712
118MP0000537_abnormal_urethra_morphology0.87763374
119MP0002925_abnormal_cardiovascular_devel0.87760707
120MP0003656_abnormal_erythrocyte_physiolo0.86790053
121MP0001851_eye_inflammation0.86563795
122MP0005257_abnormal_intraocular_pressure0.85073910
123MP0000604_amyloidosis0.84787099
124MP0001845_abnormal_inflammatory_respons0.84722678
125MP0010234_abnormal_vibrissa_follicle0.84544215
126MP0005671_abnormal_response_to0.84145936
127MP0002092_abnormal_eye_morphology0.83497782
128MP0005623_abnormal_meninges_morphology0.83468288
129MP0000428_abnormal_craniofacial_morphol0.83399830
130MP0000003_abnormal_adipose_tissue0.83261016
131MP0003091_abnormal_cell_migration0.82498482
132MP0000747_muscle_weakness0.82044455
133MP0003448_altered_tumor_morphology0.80884392
134MP0001216_abnormal_epidermal_layer0.80787876
135MP0004264_abnormal_extraembryonic_tissu0.80197178
136MP0005621_abnormal_cell_physiology0.79978291
137MP0009840_abnormal_foam_cell0.79551231
138MP0005501_abnormal_skin_physiology0.74585551
139MP0005000_abnormal_immune_tolerance0.73324366
140MP0000266_abnormal_heart_morphology0.72650306
141MP0001293_anophthalmia0.71418653
142MP0000750_abnormal_muscle_regeneration0.70358182

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.59626774
2Hyperacusis (HP:0010780)3.23071804
3Eczematoid dermatitis (HP:0000976)3.13025538
4Ependymoma (HP:0002888)2.97160236
5Basal cell carcinoma (HP:0002671)2.91614208
6Distal lower limb amyotrophy (HP:0008944)2.87633596
7Increased density of long bones (HP:0006392)2.85845668
8Broad face (HP:0000283)2.70123237
9Abnormality of the fingertips (HP:0001211)2.65894773
10Ulnar bowing (HP:0003031)2.60849072
11Reticulocytopenia (HP:0001896)2.60202883
12Vertebral compression fractures (HP:0002953)2.59300152
13Selective tooth agenesis (HP:0001592)2.58236215
14Abnormality of cells of the erythroid lineage (HP:0012130)2.56235487
15Thrombocytosis (HP:0001894)2.52057042
16Centrally nucleated skeletal muscle fibers (HP:0003687)2.49241938
17Multiple enchondromatosis (HP:0005701)2.48763449
18Distal lower limb muscle weakness (HP:0009053)2.42012159
19Increased IgE level (HP:0003212)2.41842195
20Recurrent abscess formation (HP:0002722)2.41046318
21Increased nuchal translucency (HP:0010880)2.36989368
22Abnormality of the Achilles tendon (HP:0005109)2.34814691
23Obstructive sleep apnea (HP:0002870)2.34557741
24Premature rupture of membranes (HP:0001788)2.32532818
25Abnormal number of erythroid precursors (HP:0012131)2.31072016
26Nasal polyposis (HP:0100582)2.28385395
27Abnormality of macrophages (HP:0004311)2.26827587
28Disproportionate tall stature (HP:0001519)2.24641744
29Short 4th metacarpal (HP:0010044)2.22481664
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22481664
31Shallow orbits (HP:0000586)2.20261569
32Astrocytoma (HP:0009592)2.19540625
33Abnormality of the astrocytes (HP:0100707)2.19540625
34Proximal placement of thumb (HP:0009623)2.19109128
35Upper limb amyotrophy (HP:0009129)2.18980763
36Distal upper limb amyotrophy (HP:0007149)2.18980763
37Polygenic inheritance (HP:0010982)2.18839068
38High pitched voice (HP:0001620)2.17785208
39Deviation of the thumb (HP:0009603)2.17317921
40Hand muscle atrophy (HP:0009130)2.16829503
41Cellulitis (HP:0100658)2.15916130
42Recurrent bacterial skin infections (HP:0005406)2.15669796
43Abnormality of the lower motor neuron (HP:0002366)2.15582312
44Difficulty climbing stairs (HP:0003551)2.15024054
45Long palpebral fissure (HP:0000637)2.13613774
46Obstructive lung disease (HP:0006536)2.11852883
47Chronic obstructive pulmonary disease (HP:0006510)2.11852883
48Medulloblastoma (HP:0002885)2.09589047
49Renal duplication (HP:0000075)2.08905639
50Recurrent viral infections (HP:0004429)2.07359713
51Recurrent bronchitis (HP:0002837)2.05013545
52Hypertensive crisis (HP:0100735)2.04600547
53Abnormality of the nasal mucosa (HP:0000433)2.03905299
54Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.03078483
55Abnormality of the thoracic spine (HP:0100711)2.03063426
56Protrusio acetabuli (HP:0003179)2.02717184
57T lymphocytopenia (HP:0005403)2.02629719
58Prominent nose (HP:0000448)2.02416843
59Axonal loss (HP:0003447)2.01509376
60Pustule (HP:0200039)2.01334476
61Abnormal gallbladder physiology (HP:0012438)1.98824053
62Cholecystitis (HP:0001082)1.98824053
63Genu recurvatum (HP:0002816)1.98386919
64Trismus (HP:0000211)1.98045889
65Abnormality of liposaccharide metabolism (HP:0010968)1.97178985
66Abnormality of glycosphingolipid metabolism (HP:0004343)1.97178985
67Abnormality of glycolipid metabolism (HP:0010969)1.97178985
68Rectal prolapse (HP:0002035)1.96878456
69Ankle contracture (HP:0006466)1.96009254
70Neoplasm of striated muscle (HP:0009728)1.94971323
71Gastrointestinal inflammation (HP:0004386)1.93439936
72Colon cancer (HP:0003003)1.91786190
73Insomnia (HP:0100785)1.91658202
74Gingivitis (HP:0000230)1.91460498
75Papilloma (HP:0012740)1.91028390
76Verrucae (HP:0200043)1.91028390
77Abnormality of skeletal muscle fiber size (HP:0012084)1.90650924
78Squamous cell carcinoma (HP:0002860)1.90591202
79Increased variability in muscle fiber diameter (HP:0003557)1.90444796
80Deep palmar crease (HP:0006191)1.90316972
81Increased cerebral lipofuscin (HP:0011813)1.90311893
82Cerebral inclusion bodies (HP:0100314)1.90258600
83Thin bony cortex (HP:0002753)1.90225376
84Interstitial pulmonary disease (HP:0006530)1.90021488
85Increased connective tissue (HP:0009025)1.89941977
86Thoracic kyphosis (HP:0002942)1.89883676
87Segmental peripheral demyelination/remyelination (HP:0003481)1.89868834
88Flat acetabular roof (HP:0003180)1.89484064
89Abnormality of T cells (HP:0002843)1.88327014
90Dysostosis multiplex (HP:0000943)1.87813416
91Lower limb amyotrophy (HP:0007210)1.87402804
92Mediastinal lymphadenopathy (HP:0100721)1.87173716
93Fragile skin (HP:0001030)1.87066172
94IgM deficiency (HP:0002850)1.86073246
95Pseudobulbar signs (HP:0002200)1.85950607
96Progressive muscle weakness (HP:0003323)1.84982017
97Achilles tendon contracture (HP:0001771)1.84494311
98Ragged-red muscle fibers (HP:0003200)1.84245671
99Cutaneous melanoma (HP:0012056)1.84230468
100Hemorrhage of the eye (HP:0011885)1.83912039
101Recurrent fungal infections (HP:0002841)1.83876110
102Bicuspid aortic valve (HP:0001647)1.83078752
103Skin tags (HP:0010609)1.82782153
104Poikiloderma (HP:0001029)1.81931576
105Biconcave vertebral bodies (HP:0004586)1.81592074
106Elfin facies (HP:0004428)1.81285440
107Angiofibromas (HP:0010615)1.80883200
108Adenoma sebaceum (HP:0009720)1.80883200
109Patellar aplasia (HP:0006443)1.80866008
110Panhypogammaglobulinemia (HP:0003139)1.80181848
111Rhabdomyosarcoma (HP:0002859)1.79510782
112Facial hemangioma (HP:0000329)1.79314221
113Loss of speech (HP:0002371)1.78880758
114Abnormality of reticulocytes (HP:0004312)1.78767408
115Missing ribs (HP:0000921)1.78745611
116Reticulocytosis (HP:0001923)1.78741026
117Abnormal number of incisors (HP:0011064)1.78606479
118Gastrointestinal carcinoma (HP:0002672)1.78309484
119Malignant gastrointestinal tract tumors (HP:0006749)1.78309484
120Slow saccadic eye movements (HP:0000514)1.77517456
121Abnormality of T cell number (HP:0011839)1.77400750
122Rib fusion (HP:0000902)1.77005923
123Volvulus (HP:0002580)1.76681456
124Combined immunodeficiency (HP:0005387)1.76515673
125Long eyelashes (HP:0000527)1.75998372
126Renovascular hypertension (HP:0100817)1.75493811
127Overlapping toe (HP:0001845)1.74752975
128Short nail (HP:0001799)1.73853800
129Aneurysm (HP:0002617)1.73827655
130Abnormal platelet volume (HP:0011876)1.73649903
131Colitis (HP:0002583)1.72836908
132Inflammation of the large intestine (HP:0002037)1.72313909
133Aplasia/Hypoplasia of the patella (HP:0006498)1.70840735
134Pallor (HP:0000980)1.70758874
135Gastrointestinal stroma tumor (HP:0100723)1.70512374
136Meningitis (HP:0001287)1.70337593
137Progressive external ophthalmoplegia (HP:0000590)1.70196013
138Absent thumb (HP:0009777)1.69487961
139Neoplasm of the oral cavity (HP:0100649)1.69469787
140Neuronal loss in central nervous system (HP:0002529)1.69295400
141Bowed forearm bones (HP:0003956)1.69285313
142Bowing of the arm (HP:0006488)1.69285313
143Fatigue (HP:0012378)1.68592963
144Mitral regurgitation (HP:0001653)1.68456752
145J-shaped sella turcica (HP:0002680)1.68363806
146Dilatation of the ascending aorta (HP:0005111)1.67969528
147Nuclear cataract (HP:0100018)1.67901506
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.67814935
149Osteolytic defects of the hand bones (HP:0009699)1.67814935
150Heterotopia (HP:0002282)1.67729502
151Trigonocephaly (HP:0000243)1.67690339
152Asymmetry of the thorax (HP:0001555)1.67565869
153Broad palm (HP:0001169)1.67295559
154Chronic otitis media (HP:0000389)1.66960588
155Abnormality of the 4th metacarpal (HP:0010012)1.65901504
156Increased serum ferritin (HP:0003281)1.65779028
157Abnormality of the calcaneus (HP:0008364)1.65708556
158Pointed chin (HP:0000307)1.65676994
159Abnormality of the peritoneum (HP:0002585)1.65404643
160Mitral valve prolapse (HP:0001634)1.65212842
161Emphysema (HP:0002097)1.64604126
162Premature skin wrinkling (HP:0100678)1.63758428
163Atresia of the external auditory canal (HP:0000413)1.63407039
164Ankyloglossia (HP:0010296)1.63231172
165Acute lymphatic leukemia (HP:0006721)1.62226016
166Preauricular skin tag (HP:0000384)1.61802287
167Cervical subluxation (HP:0003308)1.61765246
168Myopathic facies (HP:0002058)1.61535458
169Syringomyelia (HP:0003396)1.60854154
170Spinal cord lesions (HP:0100561)1.60854154
171Gastrointestinal dysmotility (HP:0002579)1.60511818
172Patellar dislocation (HP:0002999)1.60427176
173Back pain (HP:0003418)1.59463528
174Hyperparathyroidism (HP:0000843)1.59046413
175Blue sclerae (HP:0000592)1.58908712
176Purpura (HP:0000979)1.58852701
177Abnormality of the distal phalanges of the toes (HP:0010182)1.58601146
178Upper motor neuron abnormality (HP:0002127)1.58095928
179Generalized amyotrophy (HP:0003700)1.57400346
180Myositis (HP:0100614)1.56302542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.09994889
2TRIB33.82578562
3EEF2K3.81673891
4PRPF4B3.62096175
5SMG13.54685505
6PKN23.33463207
7CDK122.98877816
8MAP4K12.74997347
9IRAK32.67625751
10CDC72.57077146
11NEK22.42016236
12ERN11.94900377
13STK101.92283724
14ICK1.84025651
15RPS6KB21.73951636
16ALK1.73269662
17RIPK41.72363315
18CDK41.71562277
19TTN1.71264548
20TAOK21.65379463
21GRK61.58480376
22LRRK21.56383107
23MAP3K131.54616234
24IRAK41.43551115
25TESK21.43277291
26TLK11.38183331
27PTK61.37320762
28MAP3K141.26668487
29RPS6KA41.25729069
30ZAP701.25046956
31MAP3K31.22499932
32SIK21.21301348
33SCYL21.18800945
34MTOR1.15310950
35PIM11.15286671
36CDK71.13622982
37MAP3K11.13165298
38FLT31.12759853
39MAP3K81.12739215
40BMX1.12420611
41WEE11.12415450
42PDGFRA1.11118381
43MAP3K111.09267613
44CDK61.06482920
45PAK41.05554563
46MARK21.05356858
47BUB11.04690331
48TTK1.04611068
49ARAF1.02231261
50RIPK11.00205323
51TGFBR10.99702090
52BRD40.98386201
53NME20.96203743
54FGFR40.96080873
55ATR0.95318918
56IRAK20.95148387
57TSSK60.94563168
58CDC42BPA0.94399392
59BTK0.94159151
60JAK30.93011340
61CHEK10.91106543
62KSR20.90056210
63TAOK10.87972561
64TYRO30.87235032
65TYK20.85482599
66SIK30.82600297
67PAK20.80046450
68AURKB0.79805860
69TNK20.79665784
70MAP2K30.76239716
71PLK10.75995426
72PASK0.73492562
73CSF1R0.71904831
74MST1R0.71433667
75PDPK10.71361392
76NEK10.71359052
77* CDK20.71150198
78CSK0.70862749
79MAP2K20.70696923
80STK40.69562073
81MAP3K70.68020335
82MOS0.67772105
83MAPKAPK30.66985617
84BLK0.65541122
85SIK10.63723560
86DMPK0.62240763
87ITK0.61819490
88RPS6KA20.60499345
89TBK10.60336057
90PRKD20.59857098
91FES0.59702307
92HCK0.59575373
93PIM20.57155599
94ILK0.55983974
95EPHA20.55591108
96ATM0.55179917
97CHEK20.54261530
98RPS6KA10.54106399
99MAPK110.53587073
100CDK90.53229476
101CLK10.52095876
102SRPK10.52048150
103KDR0.51784269
104RPS6KC10.51733165
105RPS6KL10.51733165
106DDR20.51582622
107BRAF0.51289822
108LATS20.50335620
109FGR0.49604195
110CAMKK10.49126092
111RPS6KA60.48798471
112IKBKE0.48261233
113HIPK20.47457272
114PDGFRB0.46785371
115ACVR1B0.46765371
116CHUK0.46681660
117CAMK1D0.46612374
118RET0.46077142
119EPHB10.45693407
120TESK10.44539932
121PRKD30.43236853
122LCK0.42863333
123MAP3K60.42833666
124DYRK1B0.42108004
125DYRK30.41701559
126MAPK120.40170400
127PDK10.39529278
128KIT0.39136334
129SYK0.38316178
130JAK10.38304944
131MAPKAPK20.37864849
132PRKG20.37484130
133CDK80.37146071
134PTK20.36548764
135FGFR30.35889959
136IKBKB0.33307090

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.52482980
2Mismatch repair_Homo sapiens_hsa034302.65503923
3* Spliceosome_Homo sapiens_hsa030402.64644890
4Other glycan degradation_Homo sapiens_hsa005112.39661927
5Ribosome_Homo sapiens_hsa030102.38869547
6Base excision repair_Homo sapiens_hsa034102.38276379
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23605913
8RNA transport_Homo sapiens_hsa030132.20080872
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.03541178
10One carbon pool by folate_Homo sapiens_hsa006701.98374419
11Primary immunodeficiency_Homo sapiens_hsa053401.91657032
12Cell cycle_Homo sapiens_hsa041101.82381506
13mRNA surveillance pathway_Homo sapiens_hsa030151.81603459
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75817555
15Chronic myeloid leukemia_Homo sapiens_hsa052201.75053690
16Antigen processing and presentation_Homo sapiens_hsa046121.58801069
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56956753
18Acute myeloid leukemia_Homo sapiens_hsa052211.53953340
19Nucleotide excision repair_Homo sapiens_hsa034201.51899286
20B cell receptor signaling pathway_Homo sapiens_hsa046621.49679944
21Small cell lung cancer_Homo sapiens_hsa052221.47604061
22Homologous recombination_Homo sapiens_hsa034401.41633326
23Notch signaling pathway_Homo sapiens_hsa043301.40060244
24Prion diseases_Homo sapiens_hsa050201.38954954
25Herpes simplex infection_Homo sapiens_hsa051681.32517823
26p53 signaling pathway_Homo sapiens_hsa041151.30827290
27Renal cell carcinoma_Homo sapiens_hsa052111.30049250
28HTLV-I infection_Homo sapiens_hsa051661.29546705
29Viral carcinogenesis_Homo sapiens_hsa052031.29499788
30Lysine degradation_Homo sapiens_hsa003101.27143215
31mTOR signaling pathway_Homo sapiens_hsa041501.26853701
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23034485
33MicroRNAs in cancer_Homo sapiens_hsa052061.18636597
34VEGF signaling pathway_Homo sapiens_hsa043701.15465900
35Thyroid cancer_Homo sapiens_hsa052161.15451052
36Non-small cell lung cancer_Homo sapiens_hsa052231.14827173
37Bladder cancer_Homo sapiens_hsa052191.14690017
38Hepatitis C_Homo sapiens_hsa051601.14619894
39Fructose and mannose metabolism_Homo sapiens_hsa000511.13918360
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13637961
41Epstein-Barr virus infection_Homo sapiens_hsa051691.13231068
42Colorectal cancer_Homo sapiens_hsa052101.11699858
43Viral myocarditis_Homo sapiens_hsa054161.11432569
44Apoptosis_Homo sapiens_hsa042101.09739671
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.09057308
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08655635
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08098175
48T cell receptor signaling pathway_Homo sapiens_hsa046601.07633972
49Sulfur relay system_Homo sapiens_hsa041221.05570115
50Tuberculosis_Homo sapiens_hsa051521.05322024
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.05320566
52Salmonella infection_Homo sapiens_hsa051321.03428537
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03229221
54Non-homologous end-joining_Homo sapiens_hsa034500.99057138
55ErbB signaling pathway_Homo sapiens_hsa040120.98232755
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97688072
57Measles_Homo sapiens_hsa051620.97280795
58Pancreatic cancer_Homo sapiens_hsa052120.96890887
59Osteoclast differentiation_Homo sapiens_hsa043800.96343853
60Hepatitis B_Homo sapiens_hsa051610.96166129
61Leishmaniasis_Homo sapiens_hsa051400.96035009
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.93943194
63Adherens junction_Homo sapiens_hsa045200.92593970
64RNA degradation_Homo sapiens_hsa030180.91437113
65Shigellosis_Homo sapiens_hsa051310.91248332
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90607247
67Lysosome_Homo sapiens_hsa041420.89856306
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89824619
69Toxoplasmosis_Homo sapiens_hsa051450.89378049
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.86144499
71Proteoglycans in cancer_Homo sapiens_hsa052050.85951863
72Malaria_Homo sapiens_hsa051440.85304814
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84859803
74Endometrial cancer_Homo sapiens_hsa052130.84104150
75Galactose metabolism_Homo sapiens_hsa000520.82870926
76Endocytosis_Homo sapiens_hsa041440.81182996
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80938775
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.80194825
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.78306693
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.77872745
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77429064
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.76955993
83GnRH signaling pathway_Homo sapiens_hsa049120.76293661
84HIF-1 signaling pathway_Homo sapiens_hsa040660.75908575
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75553224
86Chemokine signaling pathway_Homo sapiens_hsa040620.74808166
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.74222019
88Inositol phosphate metabolism_Homo sapiens_hsa005620.73160993
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73119123
90Hippo signaling pathway_Homo sapiens_hsa043900.72222844
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70671949
92Biosynthesis of amino acids_Homo sapiens_hsa012300.69324111
93Focal adhesion_Homo sapiens_hsa045100.69201939
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68826090
95Legionellosis_Homo sapiens_hsa051340.68784040
96Pertussis_Homo sapiens_hsa051330.68054752
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.67655747
98Pyrimidine metabolism_Homo sapiens_hsa002400.67304993
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67201458
100Fanconi anemia pathway_Homo sapiens_hsa034600.66468478
101Platelet activation_Homo sapiens_hsa046110.65695700
102Influenza A_Homo sapiens_hsa051640.65607919
103Choline metabolism in cancer_Homo sapiens_hsa052310.65291052
104Estrogen signaling pathway_Homo sapiens_hsa049150.65168099
105Systemic lupus erythematosus_Homo sapiens_hsa053220.64665923
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63104893
107Pathways in cancer_Homo sapiens_hsa052000.62315727
108Staphylococcus aureus infection_Homo sapiens_hsa051500.61966471
109Basal cell carcinoma_Homo sapiens_hsa052170.61412814
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58712677
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58012236
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57835563
113Prolactin signaling pathway_Homo sapiens_hsa049170.57718220
114RNA polymerase_Homo sapiens_hsa030200.57147624
115Insulin resistance_Homo sapiens_hsa049310.57109375
116Allograft rejection_Homo sapiens_hsa053300.56054598
117Glioma_Homo sapiens_hsa052140.55842197
118Hematopoietic cell lineage_Homo sapiens_hsa046400.55393859
119Prostate cancer_Homo sapiens_hsa052150.54943090
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.53729164
121Oocyte meiosis_Homo sapiens_hsa041140.53082431
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51780427
123Insulin signaling pathway_Homo sapiens_hsa049100.51079802
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50017859
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49847682
126Amoebiasis_Homo sapiens_hsa051460.49311273
127TNF signaling pathway_Homo sapiens_hsa046680.49034141
128AMPK signaling pathway_Homo sapiens_hsa041520.48717617
129Pentose phosphate pathway_Homo sapiens_hsa000300.47492815
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47460359
131Selenocompound metabolism_Homo sapiens_hsa004500.47264201
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45264418

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