SART3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.18598920
2transcription from mitochondrial promoter (GO:0006390)7.18308546
3embryonic process involved in female pregnancy (GO:0060136)6.97801409
4nuclear pore complex assembly (GO:0051292)6.83472922
5replication fork processing (GO:0031297)6.75250319
6proline metabolic process (GO:0006560)6.73071514
7nuclear pore organization (GO:0006999)6.01807262
8establishment of apical/basal cell polarity (GO:0035089)5.99497049
9positive regulation of protein homooligomerization (GO:0032464)5.95192724
10DNA unwinding involved in DNA replication (GO:0006268)5.93008950
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.76113498
12regulation of integrin activation (GO:0033623)5.71997954
13DNA deamination (GO:0045006)5.67387546
14oxidative demethylation (GO:0070989)5.28915691
15somatic hypermutation of immunoglobulin genes (GO:0016446)5.27511918
16somatic diversification of immune receptors via somatic mutation (GO:0002566)5.27511918
17mitotic chromosome condensation (GO:0007076)5.20688632
18establishment or maintenance of monopolar cell polarity (GO:0061339)5.20082871
19establishment of monopolar cell polarity (GO:0061162)5.20082871
20regulation of protein homooligomerization (GO:0032462)5.08269957
21pore complex assembly (GO:0046931)5.07647759
22DNA strand renaturation (GO:0000733)5.07320575
23mitochondrial DNA metabolic process (GO:0032042)5.03493596
24mitotic G1 DNA damage checkpoint (GO:0031571)5.01194972
25mitotic sister chromatid cohesion (GO:0007064)4.89399097
26regulation of translational fidelity (GO:0006450)4.74322378
27poly(A)+ mRNA export from nucleus (GO:0016973)4.63188131
28viral mRNA export from host cell nucleus (GO:0046784)4.52690099
29negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.49907033
30mitotic G1/S transition checkpoint (GO:0044819)4.47883560
31establishment of integrated proviral latency (GO:0075713)4.47066191
32G1 DNA damage checkpoint (GO:0044783)4.42567953
33mRNA cleavage (GO:0006379)4.36998944
34embryonic placenta development (GO:0001892)4.28339548
35negative regulation of JAK-STAT cascade (GO:0046426)4.26493456
36DNA replication initiation (GO:0006270)4.25247597
37negative regulation of cell cycle arrest (GO:0071157)4.22002218
38formation of translation preinitiation complex (GO:0001731)4.21205460
39DNA duplex unwinding (GO:0032508)4.19354962
40base-excision repair (GO:0006284)4.16739167
41mitotic nuclear envelope disassembly (GO:0007077)4.16175190
42dosage compensation (GO:0007549)4.07333989
43regulation of sister chromatid cohesion (GO:0007063)4.02774974
44positive regulation of mitotic sister chromatid separation (GO:1901970)4.01939704
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.01939704
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.01939704
47protein localization to chromosome, centromeric region (GO:0071459)4.01208634
48telomere maintenance via semi-conservative replication (GO:0032201)3.99283602
49negative regulation of mRNA processing (GO:0050686)3.98896532
50DNA geometric change (GO:0032392)3.97095923
51membrane disassembly (GO:0030397)3.96683145
52nuclear envelope disassembly (GO:0051081)3.96683145
53regulation of RNA export from nucleus (GO:0046831)3.93453916
54heterochromatin organization (GO:0070828)3.89677432
55mitotic metaphase plate congression (GO:0007080)3.85381556
56protein localization to kinetochore (GO:0034501)3.85126049
57histone H4-K12 acetylation (GO:0043983)3.80067722
58DNA integration (GO:0015074)3.78968444
59negative regulation of histone methylation (GO:0031061)3.77234123
60meiotic chromosome segregation (GO:0045132)3.72592536
61positive regulation by host of viral transcription (GO:0043923)3.71280121
62DNA topological change (GO:0006265)3.71237956
63cellular response to ATP (GO:0071318)3.71173034
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.70603463
65double-strand break repair via nonhomologous end joining (GO:0006303)3.68108921
66non-recombinational repair (GO:0000726)3.68108921
67establishment of protein localization to mitochondrial membrane (GO:0090151)3.67704237
68regulation of posttranscriptional gene silencing (GO:0060147)3.67523026
69regulation of gene silencing by miRNA (GO:0060964)3.67523026
70regulation of gene silencing by RNA (GO:0060966)3.67523026
71* spliceosomal tri-snRNP complex assembly (GO:0000244)3.66171181
72negative regulation of Ras GTPase activity (GO:0034261)3.65445517
73mitotic recombination (GO:0006312)3.61963133
74nucleosome disassembly (GO:0006337)3.60375485
75protein-DNA complex disassembly (GO:0032986)3.60375485
76trophectodermal cell differentiation (GO:0001829)3.59631235
77positive regulation of protein oligomerization (GO:0032461)3.57924673
78termination of RNA polymerase II transcription (GO:0006369)3.57575989
79negative regulation of RNA splicing (GO:0033119)3.57228650
80protein complex localization (GO:0031503)3.56941630
81regulation of histone H3-K9 methylation (GO:0051570)3.56916864
82DNA conformation change (GO:0071103)3.56202223
83establishment of viral latency (GO:0019043)3.54674799
84embryonic camera-type eye development (GO:0031076)3.53805127
85negative regulation of protein oligomerization (GO:0032460)3.52927380
86regulation of double-strand break repair via homologous recombination (GO:0010569)3.50823360
87metaphase plate congression (GO:0051310)3.50799375
88convergent extension (GO:0060026)3.50070242
89apoptotic process involved in morphogenesis (GO:0060561)3.49516569
90glutamine family amino acid biosynthetic process (GO:0009084)3.46572012
91mitochondrial RNA metabolic process (GO:0000959)3.45213139
92cellular response to zinc ion (GO:0071294)3.43925034
93DNA strand elongation involved in DNA replication (GO:0006271)3.43658991
94negative regulation of fatty acid biosynthetic process (GO:0045717)3.43451990
95regulation of double-strand break repair (GO:2000779)3.42413230
96pre-miRNA processing (GO:0031054)3.42067444
97chromosome condensation (GO:0030261)3.41736994
98DNA double-strand break processing (GO:0000729)3.40638811
99mitotic sister chromatid segregation (GO:0000070)3.39006723
100face development (GO:0060324)3.37854469
101positive regulation of chromosome segregation (GO:0051984)3.37542285
102positive regulation of developmental pigmentation (GO:0048087)3.37310856
103maturation of 5.8S rRNA (GO:0000460)3.37059396
104regulation of protein oligomerization (GO:0032459)3.36454504
105base-excision repair, AP site formation (GO:0006285)3.36005647
106regulation of DNA damage checkpoint (GO:2000001)3.35498216
107ATP-dependent chromatin remodeling (GO:0043044)3.34760382
108ribosome assembly (GO:0042255)3.31092125
109negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.29041786
110DNA replication checkpoint (GO:0000076)3.29038561
111negative regulation of mRNA metabolic process (GO:1903312)3.27641997
112kinetochore assembly (GO:0051382)3.27053573
113IMP biosynthetic process (GO:0006188)3.25483834
114nodal signaling pathway (GO:0038092)3.25272106
115pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.24484526
116telomere maintenance via recombination (GO:0000722)3.23975801
117RNA stabilization (GO:0043489)3.23951034
118mRNA stabilization (GO:0048255)3.23951034
119DNA strand elongation (GO:0022616)3.22966955
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21475594
121nuclear envelope organization (GO:0006998)3.21371752
122L-serine metabolic process (GO:0006563)3.21100981
123chromatin assembly (GO:0031497)3.21084609
124regulation of hippo signaling (GO:0035330)3.16589445
125mRNA transport (GO:0051028)3.15370577
126negative regulation of chromosome segregation (GO:0051985)3.13489583
127regulation of chromosome segregation (GO:0051983)3.12403505
128DNA ligation (GO:0006266)3.12103650
129cellular protein complex localization (GO:0034629)3.11442755
130establishment of chromosome localization (GO:0051303)3.11280308
131labyrinthine layer development (GO:0060711)3.10165541
132regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10108550
133activation of Rac GTPase activity (GO:0032863)3.09865618
134anatomical structure regression (GO:0060033)3.09537982
135protein export from nucleus (GO:0006611)3.09522495
136glial cell migration (GO:0008347)3.08376413
137folic acid-containing compound biosynthetic process (GO:0009396)3.06915664
138regulation of nucleobase-containing compound transport (GO:0032239)3.05645055
139chromatin assembly or disassembly (GO:0006333)3.05103976
140determination of adult lifespan (GO:0008340)3.02283585
141positive regulation of DNA repair (GO:0045739)3.01381311
142DNA demethylation (GO:0080111)3.01234637
143negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00793057
144negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00793057
145negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00793057
146negative regulation of mitotic sister chromatid separation (GO:2000816)3.00793057
147negative regulation of sister chromatid segregation (GO:0033046)3.00793057
148DNA packaging (GO:0006323)3.00562503
149intracellular estrogen receptor signaling pathway (GO:0030520)3.00555632
150IMP metabolic process (GO:0046040)3.00235726
151peptidyl-arginine omega-N-methylation (GO:0035247)2.97399159
152regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96372119
153regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96372119
154regulation of sister chromatid segregation (GO:0033045)2.96007516
155regulation of mitotic sister chromatid separation (GO:0010965)2.96007516
156regulation of mitotic sister chromatid segregation (GO:0033047)2.96007516
157DNA synthesis involved in DNA repair (GO:0000731)2.95316615
158mRNA export from nucleus (GO:0006406)2.94336086
159regulation of centriole replication (GO:0046599)2.94073769
160sister chromatid segregation (GO:0000819)2.93852065
161regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.93834256
162ribosome biogenesis (GO:0042254)2.93411350
163kinetochore organization (GO:0051383)2.91850473
164V(D)J recombination (GO:0033151)2.89626501
165mitotic spindle checkpoint (GO:0071174)2.88609845
166chromosome segregation (GO:0007059)2.87798237
167mitotic spindle assembly checkpoint (GO:0007094)2.87629001
168DNA replication-dependent nucleosome organization (GO:0034723)2.87575614
169DNA replication-dependent nucleosome assembly (GO:0006335)2.87575614
170spindle checkpoint (GO:0031577)2.87527155
171purine nucleobase biosynthetic process (GO:0009113)2.87118549
172telomere maintenance via telomere lengthening (GO:0010833)2.86179609
173nucleic acid transport (GO:0050657)2.86108952
174RNA transport (GO:0050658)2.86108952
175establishment of RNA localization (GO:0051236)2.86108952

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.25045020
2SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.25400559
3ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.16510882
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.99837992
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.97728215
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.97728215
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.97728215
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.96851501
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.93920425
10VDR_21846776_ChIP-Seq_THP-1_Human2.55886960
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46973234
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.44925013
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42654178
14AR_21909140_ChIP-Seq_LNCAP_Human2.41789190
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37465336
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30100842
17MYC_22102868_ChIP-Seq_BL_Human2.24789278
18SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.24340278
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.16799063
20* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.16661497
21KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.11065744
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.07081250
23* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04757236
24* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04075402
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02384161
26POU5F1_16518401_ChIP-PET_MESCs_Mouse2.00931517
27CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.00563448
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96096578
29TCF3_18692474_ChIP-Seq_MESCs_Mouse1.92478130
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.92173515
31CIITA_25753668_ChIP-Seq_RAJI_Human1.88843686
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.87801814
33* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87148066
34* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85495619
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.80019484
36NANOG_21062744_ChIP-ChIP_HESCs_Human1.78233790
37LXR_22292898_ChIP-Seq_THP-1_Human1.77038497
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.74075699
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.72864502
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67675690
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.67475028
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64932293
43CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.62397744
44* EST1_17652178_ChIP-ChIP_JURKAT_Human1.60090735
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54877938
46* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54738073
47NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.53422615
48* FOXP3_21729870_ChIP-Seq_TREG_Human1.53195663
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52879211
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50001694
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49777532
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49595158
53PU.1_20513432_ChIP-Seq_Bcells_Mouse1.49398610
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49323035
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.47733075
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46876214
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44749562
58KDM2B_26808549_Chip-Seq_DND41_Human1.43720118
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43667790
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42765038
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42043117
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40326455
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39392905
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39337795
65* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39046069
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38969995
67ZNF263_19887448_ChIP-Seq_K562_Human1.38723483
68RACK7_27058665_Chip-Seq_MCF-7_Human1.37736818
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37678629
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36904733
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36158295
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36079506
73* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35677360
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34054413
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34037492
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33565755
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33294439
78* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31180930
79NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31018888
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30536464
81* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.29919883
82* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29437334
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26697424
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26624385
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.25469258
86* CHD1_26751641_Chip-Seq_LNCaP_Human1.25427317
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25029625
88* TET1_21451524_ChIP-Seq_MESCs_Mouse1.24843897
89* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24041676
90TFEB_21752829_ChIP-Seq_HELA_Human1.23442968
91SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22918363
92* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22181229
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.21341399
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.21037334
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.20285334
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.19889950
97* E2F1_21310950_ChIP-Seq_MCF-7_Human1.19568589
98XRN2_22483619_ChIP-Seq_HELA_Human1.19439437
99* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18434012
100* KDM5A_27292631_Chip-Seq_BREAST_Human1.18179358
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.17355167
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16639031
103NANOG_18692474_ChIP-Seq_MESCs_Mouse1.16484798
104* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15939521
105* GABP_19822575_ChIP-Seq_HepG2_Human1.15337113
106VDR_23849224_ChIP-Seq_CD4+_Human1.14564713
107SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12855880
108TCF7_22412390_ChIP-Seq_EML_Mouse1.11528977
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11296333
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10619623
111ELK1_19687146_ChIP-ChIP_HELA_Human1.09206972
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08904488
113* ETS1_20019798_ChIP-Seq_JURKAT_Human1.08297037
114TTF2_22483619_ChIP-Seq_HELA_Human1.08229495
115* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07917242
116ETS1_21867929_ChIP-Seq_TH2_Mouse1.07302880
117DCP1A_22483619_ChIP-Seq_HELA_Human1.06922467
118* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05281192
119PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04672095
120* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04651608
121SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04486936
122SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04183935
123CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03481469
124P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02987922
125* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02863737
126RARB_24833708_ChIP-Seq_LIVER_Mouse1.01592543
127CLOCK_20551151_ChIP-Seq_293T_Human1.01425121
128TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01339047
129RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01201028
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00422930
131* CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99624507
132HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98622110
133SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97628362
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97182791
135SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95074314
136NOTCH1_21737748_ChIP-Seq_TLL_Human0.94898987
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94782404
138SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91971369
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87931614
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87110186
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86565934
142NCOR1_26117541_ChIP-Seq_K562_Human0.82463236
143* SOX17_20123909_ChIP-Seq_XEN_Mouse0.80611512
144MAF_26560356_Chip-Seq_TH1_Human0.80497633
145KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79921533
146SOX2_16153702_ChIP-ChIP_HESCs_Human0.79901931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.95710914
2MP0009278_abnormal_bone_marrow4.21345182
3MP0010030_abnormal_orbit_morphology3.74714593
4MP0005171_absent_coat_pigmentation3.53318232
5MP0004233_abnormal_muscle_weight3.13799488
6MP0010094_abnormal_chromosome_stability2.99874025
7MP0003890_abnormal_embryonic-extraembry2.51547243
8MP0002009_preneoplasia2.51134211
9MP0004957_abnormal_blastocyst_morpholog2.51072503
10MP0003283_abnormal_digestive_organ2.47279796
11MP0003111_abnormal_nucleus_morphology2.38094887
12MP0008995_early_reproductive_senescence2.23918494
13MP0005076_abnormal_cell_differentiation2.19490419
14MP0005397_hematopoietic_system_phenotyp2.14340018
15MP0001545_abnormal_hematopoietic_system2.14340018
16MP0010234_abnormal_vibrissa_follicle2.14180887
17MP0010352_gastrointestinal_tract_polyps2.12083907
18MP0002653_abnormal_ependyma_morphology2.09498925
19MP0003119_abnormal_digestive_system2.05364563
20MP0004133_heterotaxia1.98695398
21MP0003786_premature_aging1.95446058
22MP0008058_abnormal_DNA_repair1.92552603
23MP0003077_abnormal_cell_cycle1.91926679
24MP0009672_abnormal_birth_weight1.91710502
25MP0002084_abnormal_developmental_patter1.90501949
26MP0008877_abnormal_DNA_methylation1.88439736
27MP0003693_abnormal_embryo_hatching1.85731552
28MP0002086_abnormal_extraembryonic_tissu1.84661021
29MP0005174_abnormal_tail_pigmentation1.79868771
30MP0002249_abnormal_larynx_morphology1.79688930
31MP0001697_abnormal_embryo_size1.79448583
32MP0004808_abnormal_hematopoietic_stem1.78490879
33MP0001293_anophthalmia1.74111659
34MP0002085_abnormal_embryonic_tissue1.73796309
35MP0004197_abnormal_fetal_growth/weight/1.73339131
36MP0006072_abnormal_retinal_apoptosis1.72969371
37MP0008932_abnormal_embryonic_tissue1.67491252
38MP0003453_abnormal_keratinocyte_physiol1.66280150
39MP0005380_embryogenesis_phenotype1.60145290
40MP0001672_abnormal_embryogenesis/_devel1.60145290
41MP0002282_abnormal_trachea_morphology1.56403694
42MP0000490_abnormal_crypts_of1.55111971
43MP0000350_abnormal_cell_proliferation1.55019271
44MP0001730_embryonic_growth_arrest1.53989356
45MP0004185_abnormal_adipocyte_glucose1.49592696
46MP0003567_abnormal_fetal_cardiomyocyte1.49150903
47MP0003763_abnormal_thymus_physiology1.37173862
48MP0002877_abnormal_melanocyte_morpholog1.36999015
49MP0005451_abnormal_body_composition1.35285615
50MP0009703_decreased_birth_body1.32216892
51MP0003984_embryonic_growth_retardation1.30626937
52MP0006292_abnormal_olfactory_placode1.30142083
53MP0000579_abnormal_nail_morphology1.27960588
54MP0000371_diluted_coat_color1.26212579
55MP0002088_abnormal_embryonic_growth/wei1.26206867
56MP0002080_prenatal_lethality1.24579425
57MP0010307_abnormal_tumor_latency1.23824934
58MP0003172_abnormal_lysosome_physiology1.23364566
59MP0002111_abnormal_tail_morphology1.21074164
60MP0009697_abnormal_copulation1.20017985
61MP0003221_abnormal_cardiomyocyte_apopto1.19522947
62MP0000537_abnormal_urethra_morphology1.16089648
63MP0004264_abnormal_extraembryonic_tissu1.15709797
64MP0000470_abnormal_stomach_morphology1.15496204
65MP0002269_muscular_atrophy1.14909919
66MP0000703_abnormal_thymus_morphology1.13150168
67MP0008260_abnormal_autophagy1.13094400
68MP0000462_abnormal_digestive_system1.11335289
69MP0001346_abnormal_lacrimal_gland1.10621287
70MP0000428_abnormal_craniofacial_morphol1.10327328
71MP0002019_abnormal_tumor_incidence1.10315919
72MP0005621_abnormal_cell_physiology1.08542034
73MP0000015_abnormal_ear_pigmentation1.06925307
74MP0009053_abnormal_anal_canal1.06544452
75MP0005075_abnormal_melanosome_morpholog1.05900964
76MP0003705_abnormal_hypodermis_morpholog1.05423947
77MP0002932_abnormal_joint_morphology1.05331814
78MP0003935_abnormal_craniofacial_develop1.02528831
79MP0001340_abnormal_eyelid_morphology1.01726857
80MP0002254_reproductive_system_inflammat1.01568850
81MP0005384_cellular_phenotype1.00561162
82MP0006035_abnormal_mitochondrial_morpho0.99182259
83MP0003755_abnormal_palate_morphology0.98180670
84MP0002796_impaired_skin_barrier0.96503583
85MP0003937_abnormal_limbs/digits/tail_de0.94369920
86MP0000313_abnormal_cell_death0.93288088
87MP0002114_abnormal_axial_skeleton0.91835741
88MP0002166_altered_tumor_susceptibility0.90961100
89MP0000358_abnormal_cell_content/0.90805809
90MP0001348_abnormal_lacrimal_gland0.90738331
91MP0001849_ear_inflammation0.90394776
92MP0002075_abnormal_coat/hair_pigmentati0.88202704
93MP0002006_tumorigenesis0.87576813
94MP0000639_abnormal_adrenal_gland0.86962214
95MP0000432_abnormal_head_morphology0.86619211
96MP0003828_pulmonary_edema0.85991760
97MP0000762_abnormal_tongue_morphology0.85299223
98MP0002116_abnormal_craniofacial_bone0.84649315
99MP0002398_abnormal_bone_marrow0.81919461
100MP0001286_abnormal_eye_development0.81628687
101MP0003718_maternal_effect0.79049149
102MP0005501_abnormal_skin_physiology0.77875574
103MP0002396_abnormal_hematopoietic_system0.75120552
104MP0002210_abnormal_sex_determination0.74448170
105MP0001145_abnormal_male_reproductive0.73829317
106MP0003115_abnormal_respiratory_system0.73718783
107MP0003566_abnormal_cell_adhesion0.73507707
108MP0002697_abnormal_eye_size0.73399658
109MP0010630_abnormal_cardiac_muscle0.72967019
110MP0002089_abnormal_postnatal_growth/wei0.72631386
111MP0005023_abnormal_wound_healing0.72024113
112MP0003385_abnormal_body_wall0.71831117
113MP0000467_abnormal_esophagus_morphology0.71623875
114MP0003045_fibrosis0.71611565
115MP0005058_abnormal_lysosome_morphology0.71591100
116MP0000685_abnormal_immune_system0.69761156
117MP0000477_abnormal_intestine_morphology0.69225717
118MP0009115_abnormal_fat_cell0.69161469
119MP0002060_abnormal_skin_morphology0.69135806
120MP0000377_abnormal_hair_follicle0.68832774
121MP0001186_pigmentation_phenotype0.68471671
122MP0008007_abnormal_cellular_replicative0.68428111
123MP0009333_abnormal_splenocyte_physiolog0.67652684
124MP0005266_abnormal_metabolism0.67165420
125MP0001784_abnormal_fluid_regulation0.66970022
126MP0005367_renal/urinary_system_phenotyp0.66267831
127MP0000516_abnormal_urinary_system0.66267831
128MP0002722_abnormal_immune_system0.65724324
129MP0001929_abnormal_gametogenesis0.65508984
130MP0003123_paternal_imprinting0.65448787
131MP0002092_abnormal_eye_morphology0.65320070
132MP0003941_abnormal_skin_development0.64879241
133MP0003699_abnormal_female_reproductive0.64806271
134MP0002925_abnormal_cardiovascular_devel0.64517179
135MP0003861_abnormal_nervous_system0.64124315
136MP0002233_abnormal_nose_morphology0.63979249
137MP0003121_genomic_imprinting0.63772869
138MP0001915_intracranial_hemorrhage0.63538783
139MP0002405_respiratory_system_inflammati0.62234405
140MP0003787_abnormal_imprinting0.61482417
141MP0001216_abnormal_epidermal_layer0.61063127
142MP0001727_abnormal_embryo_implantation0.60506091
143MP0000689_abnormal_spleen_morphology0.58201442
144MP0005394_taste/olfaction_phenotype0.56076254
145MP0005499_abnormal_olfactory_system0.56076254
146MP0002081_perinatal_lethality0.55925351
147MP0001188_hyperpigmentation0.55559890

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.55037771
2Facial hemangioma (HP:0000329)4.96961194
3Annular pancreas (HP:0001734)4.96171343
4Rectovaginal fistula (HP:0000143)4.58284454
5Rectal fistula (HP:0100590)4.58284454
6Concave nail (HP:0001598)4.53738014
7Pustule (HP:0200039)4.50395266
8Intestinal fistula (HP:0100819)4.34012772
9Ulnar bowing (HP:0003031)4.32923511
10Poikiloderma (HP:0001029)4.31025079
11Turricephaly (HP:0000262)4.19177699
12Chromosomal breakage induced by crosslinking agents (HP:0003221)4.14431070
13Vaginal fistula (HP:0004320)4.00627605
14Chromsome breakage (HP:0040012)3.99382953
15Increased IgM level (HP:0003496)3.91838443
16Hypochromic microcytic anemia (HP:0004840)3.85136011
17Short humerus (HP:0005792)3.82396197
18Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.80347571
19Alopecia of scalp (HP:0002293)3.75417637
20Aplasia/hypoplasia of the humerus (HP:0006507)3.69762418
21Multiple enchondromatosis (HP:0005701)3.58530403
22Tongue fasciculations (HP:0001308)3.53066004
23Coronal craniosynostosis (HP:0004440)3.50192788
24Orthostatic hypotension (HP:0001278)3.40759405
25Male infertility (HP:0003251)3.40682350
26Absent radius (HP:0003974)3.38460377
27Intestinal atresia (HP:0011100)3.35599260
28Increased nuchal translucency (HP:0010880)3.35501829
29Muscle fibrillation (HP:0010546)3.26172676
30Aplasia involving forearm bones (HP:0009822)3.17788238
31Absent forearm bone (HP:0003953)3.17788238
32Anteriorly placed anus (HP:0001545)3.16453698
33Basal cell carcinoma (HP:0002671)3.16084332
34Cortical dysplasia (HP:0002539)3.14649915
35Vertebral hypoplasia (HP:0008417)3.11155233
36Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.11155233
37Volvulus (HP:0002580)3.09827946
38Squamous cell carcinoma (HP:0002860)3.05840372
39High anterior hairline (HP:0009890)3.05089126
40Absent thumb (HP:0009777)3.01671581
41Abnormal hemoglobin (HP:0011902)3.01048845
42Congenital hip dislocation (HP:0001374)2.98124660
43Patellar aplasia (HP:0006443)2.96968827
44Selective tooth agenesis (HP:0001592)2.94729091
45Progressive external ophthalmoplegia (HP:0000590)2.94419341
46Medulloblastoma (HP:0002885)2.91421359
47Broad alveolar ridges (HP:0000187)2.89299695
48Hyperacusis (HP:0010780)2.88173548
49Nephroblastoma (Wilms tumor) (HP:0002667)2.88030288
50Short chin (HP:0000331)2.87077565
51Alacrima (HP:0000522)2.81938794
52Abnormality of the aortic arch (HP:0012303)2.80676228
53Abnormality of male internal genitalia (HP:0000022)2.78085909
54Abnormality of the fingertips (HP:0001211)2.74325095
55Aplasia/Hypoplasia of the patella (HP:0006498)2.72488320
56Astrocytoma (HP:0009592)2.68855712
57Abnormality of the astrocytes (HP:0100707)2.68855712
58Cerebral aneurysm (HP:0004944)2.68015948
59Abnormality of the labia minora (HP:0012880)2.67104221
60Embryonal renal neoplasm (HP:0011794)2.64278599
61Rhabdomyosarcoma (HP:0002859)2.60508414
62Albinism (HP:0001022)2.58814420
63Abnormality of chromosome stability (HP:0003220)2.57525945
64Dysautonomia (HP:0002459)2.55987747
65Spastic diplegia (HP:0001264)2.55672364
66Premature skin wrinkling (HP:0100678)2.55117268
67Deep philtrum (HP:0002002)2.52448187
68Hamartoma (HP:0010566)2.51704448
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48667286
70Long palpebral fissure (HP:0000637)2.47442773
71Bowing of the arm (HP:0006488)2.46434429
72Bowed forearm bones (HP:0003956)2.46434429
73Pancreatic islet-cell hyperplasia (HP:0004510)2.46134377
74Large for gestational age (HP:0001520)2.46045827
75Colon cancer (HP:0003003)2.45325529
76Premature graying of hair (HP:0002216)2.44754920
77Microvesicular hepatic steatosis (HP:0001414)2.44206646
78Hypotelorism (HP:0000601)2.44186340
79Acute lymphatic leukemia (HP:0006721)2.44073275
80Insomnia (HP:0100785)2.43401825
81Vertebral fusion (HP:0002948)2.41900456
82Hypochromic anemia (HP:0001931)2.41744873
83Deep palmar crease (HP:0006191)2.41293907
84Missing ribs (HP:0000921)2.40542380
85Choanal stenosis (HP:0000452)2.37681718
86Reticulocytopenia (HP:0001896)2.37574540
87Gastrointestinal carcinoma (HP:0002672)2.37157427
88Malignant gastrointestinal tract tumors (HP:0006749)2.37157427
89Hypotrichosis (HP:0001006)2.35709886
90Urinary glycosaminoglycan excretion (HP:0003541)2.35115781
91Mucopolysacchariduria (HP:0008155)2.35115781
92Progressive muscle weakness (HP:0003323)2.35105558
93Cafe-au-lait spot (HP:0000957)2.34822975
94Overriding aorta (HP:0002623)2.33156939
95Birth length less than 3rd percentile (HP:0003561)2.32592637
96Abnormality of the preputium (HP:0100587)2.32493687
97Diaphragmatic weakness (HP:0009113)2.31570386
98Abnormal number of incisors (HP:0011064)2.31350837
99Neoplasm of the oral cavity (HP:0100649)2.30906975
100Overlapping toe (HP:0001845)2.28273284
101Abnormality of the salivary glands (HP:0010286)2.26772337
102Myelodysplasia (HP:0002863)2.26085456
103Meckel diverticulum (HP:0002245)2.25666368
104Bifid uvula (HP:0000193)2.25228411
105Premature ovarian failure (HP:0008209)2.24016268
106Ependymoma (HP:0002888)2.23505222
107Proximal placement of thumb (HP:0009623)2.22516421
108Gastrointestinal atresia (HP:0002589)2.21815353
109Capillary hemangiomas (HP:0005306)2.21136050
110Joint stiffness (HP:0001387)2.21004497
111Split hand (HP:0001171)2.20994724
112Deviation of the thumb (HP:0009603)2.20956830
113Increased number of teeth (HP:0011069)2.19371261
114IgA deficiency (HP:0002720)2.18424893
115Prominent nose (HP:0000448)2.17488551
116Decreased lacrimation (HP:0000633)2.17078792
117Urethral obstruction (HP:0000796)2.16959037
118Obsessive-compulsive behavior (HP:0000722)2.15951556
119Dysmetric saccades (HP:0000641)2.13669522
120Short 5th finger (HP:0009237)2.12470013
121Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11161100
122Abnormality of polysaccharide metabolism (HP:0011012)2.11161100
123Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11161100
124Elfin facies (HP:0004428)2.09579797
125Skull defect (HP:0001362)2.09442445
126Uterine leiomyosarcoma (HP:0002891)2.06581174
127Leiomyosarcoma (HP:0100243)2.06581174
128Glossoptosis (HP:0000162)2.04624709
129Spinal muscular atrophy (HP:0007269)2.04228790
130Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.02711478
131Narrow nasal bridge (HP:0000446)2.02255245
132Polycythemia (HP:0001901)2.00537253
133Growth hormone excess (HP:0000845)1.99625922
134Glioma (HP:0009733)1.99543420
135Hypoplasia of the radius (HP:0002984)1.99254417
136Heterotopia (HP:0002282)1.96277738
137Abnormality of the lower motor neuron (HP:0002366)1.95995608
138Dysostosis multiplex (HP:0000943)1.95286352
139Aplasia of the musculature (HP:0100854)1.94707631
140Long eyelashes (HP:0000527)1.91235700
141Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.90550233
142Carpal bone hypoplasia (HP:0001498)1.89732331
143Clumsiness (HP:0002312)1.89574149
144Asymmetry of the thorax (HP:0001555)1.88850478
145Broad thumb (HP:0011304)1.88563472
146Impulsivity (HP:0100710)1.87078131
147Pseudobulbar signs (HP:0002200)1.86847152
148Short thumb (HP:0009778)1.86770054
149Embryonal neoplasm (HP:0002898)1.86427024
150Abnormality of the carotid arteries (HP:0005344)1.85588544
151Neuroblastic tumors (HP:0004376)1.85300727
152Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.85300727
153Neuroblastoma (HP:0003006)1.85300727
154Primitive neuroectodermal tumor (HP:0030065)1.85300727
155Breast hypoplasia (HP:0003187)1.84659771
15611 pairs of ribs (HP:0000878)1.83417067
157Horseshoe kidney (HP:0000085)1.83290008
158Vertebral arch anomaly (HP:0008438)1.82990580
159Aplasia/Hypoplasia of the uvula (HP:0010293)1.82641178
160Hypoplasia of the ulna (HP:0003022)1.81790070
161Hemivertebrae (HP:0002937)1.81776487
162Transitional cell carcinoma of the bladder (HP:0006740)1.81470595
163Abnormality of the ileum (HP:0001549)1.80136569
164High pitched voice (HP:0001620)1.79908737
165Shawl scrotum (HP:0000049)1.79859001
166Pointed chin (HP:0000307)1.79514900
167Ectopic kidney (HP:0000086)1.79486691
168Renal duplication (HP:0000075)1.79227606
169Hepatoblastoma (HP:0002884)1.77439926
170Anal stenosis (HP:0002025)1.77160678
171Sandal gap (HP:0001852)1.76281722
172Hypokinesia (HP:0002375)1.75796783
173Neoplasm of striated muscle (HP:0009728)1.74986936
174Secondary amenorrhea (HP:0000869)1.74788369
175Small intestinal stenosis (HP:0012848)1.74522756
176Duodenal stenosis (HP:0100867)1.74522756
177Atresia of the external auditory canal (HP:0000413)1.74278209
178Facial cleft (HP:0002006)1.73738962
179Trigonocephaly (HP:0000243)1.73710196
180Pelvic girdle muscle weakness (HP:0003749)1.73581702
181Renovascular hypertension (HP:0100817)1.73554901
182Neoplasm of the adrenal cortex (HP:0100641)1.72238059
183IgM deficiency (HP:0002850)1.71908453
184Abnormality of chromosome segregation (HP:0002916)1.70879239
185Popliteal pterygium (HP:0009756)1.69255488

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.92415220
2DDR24.72688548
3MAPK154.52986204
4MAP3K64.31205273
5SMG13.48190846
6MAP3K113.13221600
7SRPK13.07552484
8TYRO33.03155270
9MATK2.73325517
10FGR2.73017395
11TSSK62.67307924
12PINK12.63927741
13BRD42.60325464
14DAPK12.33901725
15BMX2.27493944
16UHMK12.18642810
17PDGFRA2.12501911
18PRKD22.12245959
19CSK2.00857078
20TAF11.97782982
21CDK71.94836734
22DYRK1B1.90820416
23YES11.80103257
24PIM21.77520744
25MKNK11.67929878
26LATS21.65554732
27PASK1.61446133
28CDK121.60784935
29MAP3K101.56660749
30PLK41.50546763
31CDK61.50319588
32VRK21.47761751
33PIM11.44790853
34TRPM71.43002460
35AKT31.35267879
36FGFR41.33314582
37CHEK21.28297762
38CAMK1D1.20862405
39PLK31.20533815
40RPS6KC11.18781576
41RPS6KL11.18781576
42CDC71.18653192
43PBK1.17692003
44MKNK21.15305249
45CAMK1G1.14066793
46CDC42BPA1.12831899
47BRSK21.10396533
48PLK11.07219802
49STK41.07165796
50NEK21.07005944
51NME21.06213902
52SCYL21.04424330
53MAPK111.03311633
54RPS6KA61.03074791
55DYRK30.98995190
56MTOR0.98270860
57GSK3A0.97846178
58RPS6KB20.97468069
59EIF2AK10.96189429
60NME10.94392541
61BRSK10.92303665
62TRIB30.90213494
63ZAK0.87231179
64PNCK0.86007195
65BRAF0.85960070
66ATR0.83651793
67MELK0.82324212
68MST40.79284396
69PHKG20.78927168
70PHKG10.78927168
71RPS6KA10.73301813
72HIPK20.72911934
73PKN20.71469753
74WEE10.70196095
75CDK90.69785725
76EPHA20.69299641
77CDK20.69030303
78LATS10.66468079
79CLK10.64824915
80ALK0.64152715
81TAOK20.64099159
82PRKAA10.63912620
83VRK10.63179776
84CHEK10.62501831
85EIF2AK30.61877239
86PRPF4B0.60675687
87EEF2K0.59280376
88RIPK10.59159647
89CDK40.58212165
90MAP3K140.57388852
91RAF10.55726977
92TTK0.53255147
93STK30.52364488
94BUB10.52214394
95NEK10.50602827
96KSR20.50233446
97AURKA0.49879720
98ATM0.49826825
99IRAK30.48796266
100AURKB0.47943805
101PDGFRB0.45121440
102STK100.44794761
103KSR10.44442683
104MAP3K90.43253996
105MAPK10.43096950
106EGFR0.42269168
107RPS6KB10.41787900
108TAOK10.41421240
109CSNK2A10.41326256
110ARAF0.41203170
111ERBB30.39851071
112MAPK140.39450062
113CDK10.39407793
114DMPK0.39187338
115PAK20.38037128
116EIF2AK20.37921439
117SIK10.36954221
118ERBB40.35685173
119LRRK20.35301382
120CSNK2A20.34889442
121MAPK100.34547409
122MAPK30.34382837
123PRKCI0.34092013
124RPS6KA40.33741005
125LYN0.33188011
126MAP3K80.32776334
127NEK60.32068095
128CDK11A0.31500285
129WNK10.31260498
130SIK20.30014211
131MAP4K10.29736581
132MAPKAPK30.28046615
133PAK40.28001893
134CSNK1G10.27722554
135FGFR10.26004923
136PTK20.24419789
137AKT10.24229811
138MAPKAPK20.23971954
139TNK20.23872058
140GSK3B0.23440365
141INSR0.23387124
142PRKAA20.22416223
143PRKDC0.21937408
144AKT20.21728487
145CSNK1E0.21166354
146PAK10.20913564
147DYRK20.20700033

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.96619123
2Base excision repair_Homo sapiens_hsa034104.56156999
3Fatty acid biosynthesis_Homo sapiens_hsa000614.38371061
4DNA replication_Homo sapiens_hsa030304.10211687
5Spliceosome_Homo sapiens_hsa030402.55193370
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52513675
7RNA transport_Homo sapiens_hsa030132.43483696
8Nucleotide excision repair_Homo sapiens_hsa034202.39192589
9mRNA surveillance pathway_Homo sapiens_hsa030152.32168981
10Notch signaling pathway_Homo sapiens_hsa043302.10364110
11mTOR signaling pathway_Homo sapiens_hsa041502.07743828
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.05842912
13Homologous recombination_Homo sapiens_hsa034402.00024853
14Hippo signaling pathway_Homo sapiens_hsa043901.93310013
15Hedgehog signaling pathway_Homo sapiens_hsa043401.90597276
16Cell cycle_Homo sapiens_hsa041101.88830005
17Fanconi anemia pathway_Homo sapiens_hsa034601.87378954
18p53 signaling pathway_Homo sapiens_hsa041151.73506749
19Adherens junction_Homo sapiens_hsa045201.67715994
20Circadian rhythm_Homo sapiens_hsa047101.64024556
21Biosynthesis of amino acids_Homo sapiens_hsa012301.43236921
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.40845989
23Basal cell carcinoma_Homo sapiens_hsa052171.38792700
24Arginine and proline metabolism_Homo sapiens_hsa003301.36735258
25Bladder cancer_Homo sapiens_hsa052191.35908195
26TGF-beta signaling pathway_Homo sapiens_hsa043501.34841568
27Lysine degradation_Homo sapiens_hsa003101.32153343
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.26322185
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23790008
30Wnt signaling pathway_Homo sapiens_hsa043101.21617268
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17248549
32Oocyte meiosis_Homo sapiens_hsa041141.16555516
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16189001
34Sulfur relay system_Homo sapiens_hsa041221.15927111
35One carbon pool by folate_Homo sapiens_hsa006701.13905533
36Selenocompound metabolism_Homo sapiens_hsa004501.13356699
37MicroRNAs in cancer_Homo sapiens_hsa052061.09048038
38Colorectal cancer_Homo sapiens_hsa052101.07777503
39Shigellosis_Homo sapiens_hsa051311.07591541
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06158209
41VEGF signaling pathway_Homo sapiens_hsa043701.01982552
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00203136
43Carbon metabolism_Homo sapiens_hsa012000.96655934
44Systemic lupus erythematosus_Homo sapiens_hsa053220.95341518
45Pentose phosphate pathway_Homo sapiens_hsa000300.95254210
46Chronic myeloid leukemia_Homo sapiens_hsa052200.93993498
47Proteasome_Homo sapiens_hsa030500.92374737
48Primary immunodeficiency_Homo sapiens_hsa053400.92363113
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89049581
50Ribosome_Homo sapiens_hsa030100.88758944
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87610251
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.83736414
53Viral carcinogenesis_Homo sapiens_hsa052030.83483931
54Small cell lung cancer_Homo sapiens_hsa052220.80876096
55Fructose and mannose metabolism_Homo sapiens_hsa000510.80601628
56Folate biosynthesis_Homo sapiens_hsa007900.78693566
57RNA degradation_Homo sapiens_hsa030180.77840158
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75078578
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74836433
60Renal cell carcinoma_Homo sapiens_hsa052110.74205772
61Thyroid cancer_Homo sapiens_hsa052160.73799992
62Acute myeloid leukemia_Homo sapiens_hsa052210.72385673
63Alcoholism_Homo sapiens_hsa050340.72362403
64Tight junction_Homo sapiens_hsa045300.72272423
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71917574
66Viral myocarditis_Homo sapiens_hsa054160.71426645
67Dorso-ventral axis formation_Homo sapiens_hsa043200.70650574
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70580210
69Measles_Homo sapiens_hsa051620.67064313
70Fatty acid metabolism_Homo sapiens_hsa012120.66131773
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63975875
72Purine metabolism_Homo sapiens_hsa002300.63601014
73Inositol phosphate metabolism_Homo sapiens_hsa005620.61455079
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.60779879
75ErbB signaling pathway_Homo sapiens_hsa040120.60409038
76HTLV-I infection_Homo sapiens_hsa051660.59631734
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59630140
78Glioma_Homo sapiens_hsa052140.58691032
79Herpes simplex infection_Homo sapiens_hsa051680.55727812
80AMPK signaling pathway_Homo sapiens_hsa041520.55677933
81Epstein-Barr virus infection_Homo sapiens_hsa051690.55605325
82Choline metabolism in cancer_Homo sapiens_hsa052310.55317885
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54898557
84Proteoglycans in cancer_Homo sapiens_hsa052050.53716833
85Gap junction_Homo sapiens_hsa045400.53444152
86Endometrial cancer_Homo sapiens_hsa052130.53221748
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50887957
88Legionellosis_Homo sapiens_hsa051340.50659145
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50612214
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.50380243
91T cell receptor signaling pathway_Homo sapiens_hsa046600.49954632
92Insulin signaling pathway_Homo sapiens_hsa049100.49513071
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48857821
94Basal transcription factors_Homo sapiens_hsa030220.46998209
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.45533627
96Influenza A_Homo sapiens_hsa051640.45489379
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.44250349
98Steroid biosynthesis_Homo sapiens_hsa001000.43235021
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.41796888
100RNA polymerase_Homo sapiens_hsa030200.41460101
101Hepatitis C_Homo sapiens_hsa051600.40396219
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40361583
103FoxO signaling pathway_Homo sapiens_hsa040680.40305562
104Galactose metabolism_Homo sapiens_hsa000520.40287228
105Pathways in cancer_Homo sapiens_hsa052000.40260848
106Hepatitis B_Homo sapiens_hsa051610.39092258
107N-Glycan biosynthesis_Homo sapiens_hsa005100.39033698
108Arginine biosynthesis_Homo sapiens_hsa002200.38186136
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37789525
110MAPK signaling pathway_Homo sapiens_hsa040100.36422057
111Pancreatic cancer_Homo sapiens_hsa052120.36361459
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35489373
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35064269
114Prostate cancer_Homo sapiens_hsa052150.34813678
115Pyrimidine metabolism_Homo sapiens_hsa002400.34472822
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34192557
117B cell receptor signaling pathway_Homo sapiens_hsa046620.33865594
118Non-homologous end-joining_Homo sapiens_hsa034500.32930541
119HIF-1 signaling pathway_Homo sapiens_hsa040660.32751518
120Focal adhesion_Homo sapiens_hsa045100.32176422
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32058676
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30139771
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24075991
124Non-small cell lung cancer_Homo sapiens_hsa052230.23054801
125Estrogen signaling pathway_Homo sapiens_hsa049150.22829556
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20340913
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.19389867
128Apoptosis_Homo sapiens_hsa042100.18875795

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