SASH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a Src homology-3 (SH3) domain and a sterile alpha motif (SAM), both of which are found in proteins involved in cell signaling. This protein may function as a signaling adapter protein in lymphocytes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.94485405
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.15164991
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.15164991
4antigen processing and presentation of endogenous antigen (GO:0019883)5.77141458
5regulation of gamma-delta T cell differentiation (GO:0045586)5.61823049
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.49096560
7regulation of B cell receptor signaling pathway (GO:0050855)5.15616229
8regulation of gamma-delta T cell activation (GO:0046643)5.07161666
9negative T cell selection (GO:0043383)5.05228280
10interferon-gamma production (GO:0032609)5.02181674
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97752472
12negative thymic T cell selection (GO:0045060)4.89707130
13negative regulation of cell killing (GO:0031342)4.73378136
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.73378136
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.62568404
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.62568404
17modulation by symbiont of host immune response (GO:0052553)4.62568404
18positive regulation by symbiont of host defense response (GO:0052509)4.62568404
19modulation by symbiont of host defense response (GO:0052031)4.62568404
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.62568404
21regulation of B cell differentiation (GO:0045577)4.62130327
22positive thymic T cell selection (GO:0045059)4.57928723
23response to interleukin-15 (GO:0070672)4.50081070
24detection of other organism (GO:0098543)4.45248205
25detection of bacterium (GO:0016045)4.44329733
26neutrophil activation involved in immune response (GO:0002283)4.42869096
27B cell receptor signaling pathway (GO:0050853)4.37144317
28ribosomal small subunit assembly (GO:0000028)4.31450520
29positive regulation of B cell differentiation (GO:0045579)4.28526799
30cellular response to interleukin-15 (GO:0071350)4.23863546
31leukocyte aggregation (GO:0070486)4.19532902
32mast cell activation (GO:0045576)4.17705643
33thymic T cell selection (GO:0045061)4.06891076
34positive T cell selection (GO:0043368)4.02409416
35T cell selection (GO:0045058)3.95264153
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.91930112
37response to peptidoglycan (GO:0032494)3.91382411
38T cell migration (GO:0072678)3.91119045
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.90700945
40macrophage activation involved in immune response (GO:0002281)3.87000779
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.85416995
42T cell homeostasis (GO:0043029)3.74086017
43regulation of T cell tolerance induction (GO:0002664)3.73692191
44negative regulation of interleukin-12 production (GO:0032695)3.71979440
45antigen receptor-mediated signaling pathway (GO:0050851)3.69832452
46negative regulation of T cell mediated immunity (GO:0002710)3.63911692
47mast cell degranulation (GO:0043303)3.63248774
48mast cell activation involved in immune response (GO:0002279)3.63248774
49negative regulation of leukocyte mediated immunity (GO:0002704)3.62180911
50antigen processing and presentation via MHC class Ib (GO:0002475)3.62082383
51regulation of interferon-beta biosynthetic process (GO:0045357)3.62021317
52regulation of T cell receptor signaling pathway (GO:0050856)3.61529609
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.60185752
54negative regulation of phagocytosis (GO:0050765)3.58002494
55T cell receptor signaling pathway (GO:0050852)3.56539082
56respiratory burst (GO:0045730)3.55096161
57positive regulation of tolerance induction (GO:0002645)3.53804999
58neutrophil activation (GO:0042119)3.52708926
59detection of external biotic stimulus (GO:0098581)3.49666822
60response to muramyl dipeptide (GO:0032495)3.49508100
61myeloid cell activation involved in immune response (GO:0002275)3.45316248
62T cell costimulation (GO:0031295)3.45283657
63regulation of isotype switching to IgG isotypes (GO:0048302)3.42174167
64lymphocyte costimulation (GO:0031294)3.41685439
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.41099751
66response to host immune response (GO:0052572)3.41099751
67regulation of dendritic cell antigen processing and presentation (GO:0002604)3.37654909
68regulation of mast cell degranulation (GO:0043304)3.35871834
69regulation of antigen processing and presentation (GO:0002577)3.25914247
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.24697263
71granulocyte activation (GO:0036230)3.24670861
72Arp2/3 complex-mediated actin nucleation (GO:0034314)3.23688257
73regulation of T cell mediated cytotoxicity (GO:0001914)3.21472064
74regulation of tolerance induction (GO:0002643)3.21376128
75regulation of interleukin-12 biosynthetic process (GO:0045075)3.20051486
76immunoglobulin mediated immune response (GO:0016064)3.17586808
77viral transcription (GO:0019083)3.17559257
78positive regulation of antigen processing and presentation (GO:0002579)3.16904211
79myeloid dendritic cell activation (GO:0001773)3.15316419
80lymphocyte homeostasis (GO:0002260)3.14593983
81leukocyte degranulation (GO:0043299)3.14199766
82negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.13522436
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11940562
84response to host (GO:0075136)3.11940562
85response to host defenses (GO:0052200)3.11940562
86positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10818107
87megakaryocyte development (GO:0035855)3.09477949
88tolerance induction (GO:0002507)3.09149591
89regulation of alpha-beta T cell proliferation (GO:0046640)3.08442913
90negative regulation of innate immune response (GO:0045824)3.06387416
91cellular response to zinc ion (GO:0071294)3.05999447
92detection of biotic stimulus (GO:0009595)3.05909410
93regulation of mast cell activation involved in immune response (GO:0033006)3.05709219
94activated T cell proliferation (GO:0050798)3.04423647
95positive regulation of mast cell activation (GO:0033005)3.04365848
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03503609
97regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02332736
98translational termination (GO:0006415)3.01678837
99germinal center formation (GO:0002467)2.98545281
100positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97977051
101regulation of regulatory T cell differentiation (GO:0045589)2.96596097
102lymph node development (GO:0048535)2.96546799
103positive regulation of granulocyte differentiation (GO:0030854)2.96306953
104regulation of mast cell activation (GO:0033003)2.95727839
105positive regulation of isotype switching (GO:0045830)2.93139568
106B cell homeostasis (GO:0001782)2.92536868
107negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.92377948
108natural killer cell activation (GO:0030101)2.92056798
109mature B cell differentiation (GO:0002335)2.91413530
110leukocyte homeostasis (GO:0001776)2.88730384
111regulation of type I interferon-mediated signaling pathway (GO:0060338)2.88483157
112response to type I interferon (GO:0034340)2.87934581
113mature B cell differentiation involved in immune response (GO:0002313)2.86114232
114T cell differentiation (GO:0030217)2.85647500
115regulation of interleukin-2 biosynthetic process (GO:0045076)2.85546087
116cellular response to type I interferon (GO:0071357)2.85055022
117type I interferon signaling pathway (GO:0060337)2.85055022
118leukocyte cell-cell adhesion (GO:0007159)2.84654540
119positive regulation of alpha-beta T cell proliferation (GO:0046641)2.83521108
120regulation of response to interferon-gamma (GO:0060330)2.83432001
121negative regulation of T cell receptor signaling pathway (GO:0050860)2.83303173
122cellular extravasation (GO:0045123)2.82839345
123immune response-activating cell surface receptor signaling pathway (GO:0002429)2.81050889
124regulation of natural killer cell mediated immunity (GO:0002715)2.80162678
125regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.80162678
126B cell mediated immunity (GO:0019724)2.80013438
127NIK/NF-kappaB signaling (GO:0038061)2.78317184
128regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.77741372
129negative regulation of erythrocyte differentiation (GO:0045647)2.75520655
130response to protozoan (GO:0001562)2.73480742
131* positive regulation of interleukin-2 production (GO:0032743)2.72644045
132natural killer cell differentiation (GO:0001779)2.72467070
133positive regulation of lamellipodium assembly (GO:0010592)2.71147781
134myeloid dendritic cell differentiation (GO:0043011)2.68318906
135ribosomal small subunit biogenesis (GO:0042274)2.67923785
136defense response to protozoan (GO:0042832)2.67704983
137T cell proliferation (GO:0042098)2.67512017
138mucosal-associated lymphoid tissue development (GO:0048537)2.66980849
139Peyers patch development (GO:0048541)2.66980849
140interferon-gamma-mediated signaling pathway (GO:0060333)2.66913484
141T cell activation (GO:0042110)2.66430177
142positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.65450948
143positive regulation of natural killer cell mediated immunity (GO:0002717)2.65450948
144translational elongation (GO:0006414)2.64606598
145cellular response to interferon-beta (GO:0035458)2.64516213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.52120739
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.22108064
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.16704011
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.95052030
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.61206634
6MYC_22102868_ChIP-Seq_BL_Human3.36919972
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31553888
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.02219514
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.96102702
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.81206286
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.75215821
12SCL_19346495_ChIP-Seq_HPC-7_Human2.75090583
13MYB_26560356_Chip-Seq_TH2_Human2.59666382
14VDR_21846776_ChIP-Seq_THP-1_Human2.55842720
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.55243321
16* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.49366075
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.46808569
18RUNX_20019798_ChIP-Seq_JUKART_Human2.46044052
19* MAF_26560356_Chip-Seq_TH1_Human2.38987926
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.34224288
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31626737
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31575743
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30529204
24MYB_26560356_Chip-Seq_TH1_Human2.30173937
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27141018
26* SPI1_23547873_ChIP-Seq_NB4_Human2.25034074
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.22260220
28* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.22207161
29* UTX_26944678_Chip-Seq_JUKART_Human2.14861401
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12443806
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.05988364
32* IRF8_27001747_Chip-Seq_BMDM_Mouse2.04162103
33* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01225263
34* RUNX1_22412390_ChIP-Seq_EML_Mouse2.00159926
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99645801
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96536531
37* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94706525
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.89536536
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88010151
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84635175
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82211581
42VDR_24763502_ChIP-Seq_THP-1_Human1.81674924
43CIITA_25753668_ChIP-Seq_RAJI_Human1.77916465
44TCF7_22412390_ChIP-Seq_EML_Mouse1.76432373
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76011802
46* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72286685
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.69435850
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68149720
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64188569
50MAF_26560356_Chip-Seq_TH2_Human1.63522958
51VDR_23849224_ChIP-Seq_CD4+_Human1.58145822
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56314681
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.56308601
54FOXP3_21729870_ChIP-Seq_TREG_Human1.55956446
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53786110
56SPI1_23127762_ChIP-Seq_K562_Human1.50786314
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46560433
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46225549
59* GATA3_27048872_Chip-Seq_THYMUS_Human1.44881925
60* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43305049
61GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.42647559
62VDR_24787735_ChIP-Seq_THP-1_Human1.42547203
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38948833
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37850707
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.35977761
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.33845691
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30562379
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30085405
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26961317
70* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26208811
71LXR_22292898_ChIP-Seq_THP-1_Human1.25505799
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25402727
73* BCL6_27268052_Chip-Seq_Bcells_Human1.22966248
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21804456
75* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20662178
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15984684
77GATA1_22025678_ChIP-Seq_K562_Human1.13521245
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13133401
79KDM2B_26808549_Chip-Seq_DND41_Human1.12567527
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12480858
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12194259
82PU_27001747_Chip-Seq_BMDM_Mouse1.12173391
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10944985
84MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10351041
85* BCOR_27268052_Chip-Seq_Bcells_Human1.09435706
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08968429
87* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07768197
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06729841
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06229738
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06181163
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.05490060
92XRN2_22483619_ChIP-Seq_HELA_Human1.05458148
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05038041
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.04099096
95GATA1_19941826_ChIP-Seq_K562_Human1.03775731
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03008072
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02989867
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02852380
99MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02066952
100ETS1_20019798_ChIP-Seq_JURKAT_Human1.01197313
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00323761
102GATA3_26560356_Chip-Seq_TH2_Human0.98266524
103* ELF1_20517297_ChIP-Seq_JURKAT_Human0.97530732
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96152069
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95764223
106* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95307946
107* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92750368
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92460983
109* GATA1_19941827_ChIP-Seq_MEL_Mouse0.92431058
110ELK1_19687146_ChIP-ChIP_HELA_Human0.91724263
111SPI1_20517297_ChIP-Seq_HL60_Human0.91501372
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91404454
113KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91237832
114NCOR1_26117541_ChIP-Seq_K562_Human0.90049254
115GABP_19822575_ChIP-Seq_HepG2_Human0.89073060
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88498176
117STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86728860
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.86272423
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85854030
120E2F1_21310950_ChIP-Seq_MCF-7_Human0.85750261
121KDM5A_27292631_Chip-Seq_BREAST_Human0.85280074
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84809506
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84765161
124NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84473057
125HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83184630
126PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82008225
127P300_27268052_Chip-Seq_Bcells_Human0.82007406
128CREB1_15753290_ChIP-ChIP_HEK293T_Human0.81089557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.20680660
2MP0003763_abnormal_thymus_physiology3.96408868
3* MP0005671_abnormal_response_to3.74416798
4MP0000685_abnormal_immune_system3.42514806
5* MP0001800_abnormal_humoral_immune3.34725570
6MP0002396_abnormal_hematopoietic_system3.33459608
7MP0001790_abnormal_immune_system3.00227327
8MP0005387_immune_system_phenotype3.00227327
9MP0009785_altered_susceptibility_to2.91150675
10* MP0002398_abnormal_bone_marrow2.89350247
11MP0005000_abnormal_immune_tolerance2.88622582
12* MP0002420_abnormal_adaptive_immunity2.86585644
13* MP0001819_abnormal_immune_cell2.82298721
14* MP0002452_abnormal_antigen_presenting2.80944042
15* MP0002723_abnormal_immune_serum2.80592656
16MP0002166_altered_tumor_susceptibility2.71500593
17MP0003436_decreased_susceptibility_to2.66290894
18MP0005025_abnormal_response_to2.57560287
19* MP0000716_abnormal_immune_system2.51305114
20* MP0000689_abnormal_spleen_morphology2.38700168
21* MP0002722_abnormal_immune_system2.38214651
22MP0000703_abnormal_thymus_morphology2.30294218
23MP0002006_tumorigenesis2.29952543
24MP0002148_abnormal_hypersensitivity_rea2.27160104
25MP0004808_abnormal_hematopoietic_stem2.21264532
26MP0005464_abnormal_platelet_physiology2.21068305
27MP0009333_abnormal_splenocyte_physiolog2.18709259
28MP0002405_respiratory_system_inflammati2.18284799
29* MP0002429_abnormal_blood_cell2.16041113
30MP0002419_abnormal_innate_immunity2.15147984
31MP0001873_stomach_inflammation2.09709523
32MP0010155_abnormal_intestine_physiology2.00149625
33MP0006082_CNS_inflammation1.95995746
34MP0003303_peritoneal_inflammation1.83601627
35MP0005174_abnormal_tail_pigmentation1.78052938
36MP0003866_abnormal_defecation1.76145605
37MP0000465_gastrointestinal_hemorrhage1.72953446
38MP0001853_heart_inflammation1.69154834
39* MP0001845_abnormal_inflammatory_respons1.69016342
40MP0000490_abnormal_crypts_of1.66161090
41MP0004947_skin_inflammation1.63601837
42MP0005075_abnormal_melanosome_morpholog1.62955385
43MP0003724_increased_susceptibility_to1.61764951
44MP0001545_abnormal_hematopoietic_system1.57221503
45MP0005397_hematopoietic_system_phenotyp1.57221503
46MP0003300_gastrointestinal_ulcer1.52378393
47MP0005310_abnormal_salivary_gland1.44473584
48MP0002933_joint_inflammation1.38423961
49MP0010094_abnormal_chromosome_stability1.37835444
50MP0008057_abnormal_DNA_replication1.36152287
51MP0002019_abnormal_tumor_incidence1.31693486
52MP0008260_abnormal_autophagy1.24324668
53MP0003828_pulmonary_edema1.24193860
54MP0008469_abnormal_protein_level1.22748647
55MP0000858_altered_metastatic_potential1.20265839
56MP0003077_abnormal_cell_cycle1.20037052
57MP0009278_abnormal_bone_marrow1.18979889
58MP0005451_abnormal_body_composition1.14938728
59MP0004510_myositis1.14891456
60MP0002009_preneoplasia1.12414193
61MP0001533_abnormal_skeleton_physiology1.10204199
62MP0002138_abnormal_hepatobiliary_system1.10022845
63MP0002132_abnormal_respiratory_system1.09587767
64MP0003693_abnormal_embryo_hatching1.08722443
65MP0002095_abnormal_skin_pigmentation1.05703529
66MP0004957_abnormal_blastocyst_morpholog1.04739275
67MP0010352_gastrointestinal_tract_polyps1.02704207
68MP0003448_altered_tumor_morphology1.01917403
69MP0000015_abnormal_ear_pigmentation0.97084323
70MP0008058_abnormal_DNA_repair0.96930740
71MP0003075_altered_response_to0.96346317
72MP0008007_abnormal_cellular_replicative0.94695765
73MP0003183_abnormal_peptide_metabolism0.91532213
74MP0003172_abnormal_lysosome_physiology0.91189668
75MP0002277_abnormal_respiratory_mucosa0.90387300
76MP0006054_spinal_hemorrhage0.90196665
77MP0004883_abnormal_blood_vessel0.88670988
78MP0003111_abnormal_nucleus_morphology0.81799112
79MP0000313_abnormal_cell_death0.79159889
80MP0001851_eye_inflammation0.78044428
81MP0003045_fibrosis0.75501555
82MP0000604_amyloidosis0.75022184
83MP0003690_abnormal_glial_cell0.72236248
84MP0009763_increased_sensitivity_to0.71614811
85MP0000343_altered_response_to0.71426857
86MP0005390_skeleton_phenotype0.70306254
87MP0003191_abnormal_cellular_cholesterol0.68032147
88MP0009764_decreased_sensitivity_to0.67825174
89MP0004381_abnormal_hair_follicle0.64224615
90MP0002998_abnormal_bone_remodeling0.64112189
91MP0009840_abnormal_foam_cell0.63858322
92MP0000477_abnormal_intestine_morphology0.61282269
93MP0005058_abnormal_lysosome_morphology0.60528064
94MP0003943_abnormal_hepatobiliary_system0.60513315
95MP0001986_abnormal_taste_sensitivity0.59824150
96MP0003806_abnormal_nucleotide_metabolis0.59752923
97MP0005023_abnormal_wound_healing0.58557851
98MP0001663_abnormal_digestive_system0.58337592
99MP0008874_decreased_physiological_sensi0.57286373
100MP0010307_abnormal_tumor_latency0.56866120
101MP0005164_abnormal_response_to0.56847713
102MP0002693_abnormal_pancreas_physiology0.55624069
103MP0002136_abnormal_kidney_physiology0.55009177
104MP0000249_abnormal_blood_vessel0.54640060
105MP0008961_abnormal_basal_metabolism0.53710888
106MP0000371_diluted_coat_color0.53477619
107MP0000350_abnormal_cell_proliferation0.53257324
108MP0008004_abnormal_stomach_pH0.52954516
109MP0009765_abnormal_xenobiotic_induced0.52586884
110MP0008873_increased_physiological_sensi0.51987075
111MP0002075_abnormal_coat/hair_pigmentati0.48010569
112MP0003656_abnormal_erythrocyte_physiolo0.47492953
113MP0000598_abnormal_liver_morphology0.46792498
114MP0003795_abnormal_bone_structure0.46643227
115MP0003252_abnormal_bile_duct0.43317138
116MP0005319_abnormal_enzyme/_coenzyme0.42763346
117MP0000609_abnormal_liver_physiology0.42538835
118MP0005166_decreased_susceptibility_to0.42470032
119MP0002083_premature_death0.41239456
120MP0003091_abnormal_cell_migration0.40267563
121MP0005381_digestive/alimentary_phenotyp0.38645143
122MP0009642_abnormal_blood_homeostasis0.35720280

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.24599894
2Abnormality of T cell number (HP:0011839)5.00108018
3Recurrent bronchitis (HP:0002837)4.91923241
4Elevated erythrocyte sedimentation rate (HP:0003565)4.86763981
5IgM deficiency (HP:0002850)4.85219836
6Panhypogammaglobulinemia (HP:0003139)4.70262120
7Recurrent viral infections (HP:0004429)4.66073781
8Chronic otitis media (HP:0000389)4.54713895
9Myositis (HP:0100614)4.41238338
10Agammaglobulinemia (HP:0004432)4.38563593
11Abnormality of T cells (HP:0002843)4.36665987
12Recurrent fungal infections (HP:0002841)4.26816729
13Recurrent gram-negative bacterial infections (HP:0005420)4.03068268
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.00956848
15Recurrent abscess formation (HP:0002722)3.93748939
16Combined immunodeficiency (HP:0005387)3.86554597
17B lymphocytopenia (HP:0010976)3.82755594
18Abnormality of B cell number (HP:0010975)3.82755594
19Severe combined immunodeficiency (HP:0004430)3.82171566
20Thrombocytosis (HP:0001894)3.82103507
21IgG deficiency (HP:0004315)3.79990412
22Thyroiditis (HP:0100646)3.79914182
23Meningitis (HP:0001287)3.75707482
24Nasal polyposis (HP:0100582)3.72146540
25Recurrent cutaneous fungal infections (HP:0011370)3.68229283
26Chronic mucocutaneous candidiasis (HP:0002728)3.68229283
27Abnormality of T cell physiology (HP:0011840)3.53967019
28Gastrointestinal infarctions (HP:0005244)3.45878839
29Eczematoid dermatitis (HP:0000976)3.45519688
30Lymphopenia (HP:0001888)3.40947491
31Cellulitis (HP:0100658)3.39716273
32Recurrent bacterial skin infections (HP:0005406)3.36780820
33Petechiae (HP:0000967)3.29649825
34Increased IgM level (HP:0003496)3.29531446
35Abnormality of cells of the lymphoid lineage (HP:0012140)3.28648874
36Abnormality of the nasal mucosa (HP:0000433)3.27798340
37Gastrointestinal inflammation (HP:0004386)3.26457550
38Inflammation of the large intestine (HP:0002037)3.24501505
39Urticaria (HP:0001025)3.19653759
40Recurrent sinusitis (HP:0011108)3.10911560
41Hypoplasia of the thymus (HP:0000778)3.07942927
42Orchitis (HP:0100796)3.07813300
43Abnormality of eosinophils (HP:0001879)3.04549740
44Recurrent skin infections (HP:0001581)3.03424435
45Vasculitis (HP:0002633)3.03240086
46Eosinophilia (HP:0001880)3.00441697
47Retrobulbar optic neuritis (HP:0100654)2.99195816
48Optic neuritis (HP:0100653)2.99195816
49Prolonged bleeding time (HP:0003010)2.91529214
50Pustule (HP:0200039)2.89855009
51Colitis (HP:0002583)2.88038801
52Leukocytosis (HP:0001974)2.87882204
53Gastrointestinal stroma tumor (HP:0100723)2.87025898
54Gingivitis (HP:0000230)2.85634688
55Encephalitis (HP:0002383)2.85442326
56Mediastinal lymphadenopathy (HP:0100721)2.85342319
57Granulocytopenia (HP:0001913)2.82765668
58Lymphoma (HP:0002665)2.76636786
59Abnormal number of erythroid precursors (HP:0012131)2.76418233
60Abnormality of cells of the erythroid lineage (HP:0012130)2.76333231
61Bronchitis (HP:0012387)2.74924746
62Abnormality of the fingertips (HP:0001211)2.74001894
63Chronic diarrhea (HP:0002028)2.73503348
64Papilloma (HP:0012740)2.73415168
65Verrucae (HP:0200043)2.73415168
66Stomatitis (HP:0010280)2.73194374
67Chronic sinusitis (HP:0011109)2.70737118
68Obstructive lung disease (HP:0006536)2.66961630
69Chronic obstructive pulmonary disease (HP:0006510)2.66961630
70IgA deficiency (HP:0002720)2.65497806
71Spontaneous hematomas (HP:0007420)2.57633417
72Epistaxis (HP:0000421)2.52332571
73Autoimmune thrombocytopenia (HP:0001973)2.49171989
74Pulmonary embolism (HP:0002204)2.41365060
75Pulmonary infiltrates (HP:0002113)2.38825755
76Recurrent pneumonia (HP:0006532)2.37656781
77Aplastic anemia (HP:0001915)2.32475452
78Abnormality of the pleura (HP:0002103)2.30670860
79Hemoptysis (HP:0002105)2.25016850
80Abnormality of the prostate (HP:0008775)2.24516561
81Keratoconjunctivitis sicca (HP:0001097)2.22453360
82Anorexia (HP:0002039)2.21954200
83Autoimmune hemolytic anemia (HP:0001890)2.20721729
84Increased IgE level (HP:0003212)2.20593181
85Arterial thrombosis (HP:0004420)2.20523178
86Basal cell carcinoma (HP:0002671)2.19381384
87Viral hepatitis (HP:0006562)2.16127834
88Episodic fever (HP:0001954)2.14840665
89Purpura (HP:0000979)2.14550194
90Emphysema (HP:0002097)2.13173085
91Osteomyelitis (HP:0002754)2.13117872
92Chest pain (HP:0100749)2.11695159
93Gangrene (HP:0100758)2.09341943
94Hypochromic anemia (HP:0001931)2.08815734
95Aplasia/Hypoplasia of the thymus (HP:0010515)2.07792835
96Reticulocytopenia (HP:0001896)2.07342286
97Sepsis (HP:0100806)2.06443889
98Abnormality of liposaccharide metabolism (HP:0010968)2.05708507
99Abnormality of glycosphingolipid metabolism (HP:0004343)2.05708507
100Abnormality of glycolipid metabolism (HP:0010969)2.05708507
101Abnormality of macrophages (HP:0004311)2.04793205
102Amaurosis fugax (HP:0100576)2.04504040
103Hypochromic microcytic anemia (HP:0004840)2.04262099
104Gingival bleeding (HP:0000225)2.04182834
105Hypergammaglobulinemia (HP:0010702)2.03085399
106Interstitial pulmonary disease (HP:0006530)2.02698118
107Abnormal platelet function (HP:0011869)2.02243476
108Impaired platelet aggregation (HP:0003540)2.02243476
109Joint swelling (HP:0001386)2.01681694
110Poikiloderma (HP:0001029)2.00805364
111Microcytic anemia (HP:0001935)2.00634573
112Keratoconjunctivitis (HP:0001096)1.99690740
113Premature loss of primary teeth (HP:0006323)1.99618089
114Glomerulopathy (HP:0100820)1.99547628
115Increased cerebral lipofuscin (HP:0011813)1.98926077
116Recurrent otitis media (HP:0000403)1.98448554
117Hepatosplenomegaly (HP:0001433)1.96741691
118Skin ulcer (HP:0200042)1.95520048
119Recurrent lower respiratory tract infections (HP:0002783)1.94414170
120Acute hepatic failure (HP:0006554)1.94333191
121Periodontitis (HP:0000704)1.93781123
122Arthralgia (HP:0002829)1.93152995
123Skin rash (HP:0000988)1.91958109
124Restrictive lung disease (HP:0002091)1.90358602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.50758108
2TXK3.49288514
3GRK62.70934724
4ZAP702.68591175
5PRPF4B2.66480857
6STK102.54213715
7KIT2.45917804
8EEF2K2.43007705
9JAK32.41553960
10TGFBR22.34756318
11BTK2.26893227
12ITK2.20632072
13SYK2.08603621
14TYK22.08213030
15CSF1R2.05660796
16TEC1.98678004
17BLK1.94360807
18IKBKE1.77746209
19NME21.74158184
20MAP3K101.72532539
21IRAK41.67871934
22TBK11.63774987
23MAP2K31.61371962
24LCK1.60985876
25FLT31.58385772
26PKN21.51758917
27ERN11.45585916
28MAP3K111.41626923
29CSK1.39145751
30LRRK21.38504508
31JAK11.35882293
32HCK1.34909407
33NLK1.31125853
34KDR1.30641785
35FGFR41.29937156
36FGR1.26305440
37FES1.24070246
38CLK11.21174445
39MAP3K141.19453188
40LYN1.17873198
41IKBKB1.15472454
42FGFR31.12629622
43PIM11.11989229
44TESK21.06092454
45BMPR21.04577407
46MAP3K121.01298856
47TAOK11.00861587
48CDK121.00375034
49MAP3K10.99308399
50MAP3K30.97829089
51SMG10.94991336
52SIK20.92712824
53RPS6KB20.91184016
54TGFBR10.85874188
55MST40.85339553
56NEK90.85139075
57MARK30.81478638
58PRKCQ0.80955203
59ADRBK20.78327931
60CDC70.77204249
61TNK20.76421954
62HIPK20.75128110
63RIPK40.74860713
64KSR20.74292389
65MAP3K130.74263028
66CDK40.74173882
67RPS6KA40.73939426
68PASK0.68960520
69SIK30.68111823
70STK40.67960978
71MATK0.66874029
72TAOK20.66594788
73NEK20.66274812
74TRIB30.65798689
75CHUK0.64356093
76MAP2K60.62334644
77JAK20.61371272
78PRKCH0.58089020
79CDC42BPA0.57938414
80PRKD20.57555393
81MAP2K20.57219249
82ILK0.56494544
83PIM20.56192699
84MAP3K70.55920729
85CAMKK10.53916968
86EIF2AK30.53612040
87YES10.52780683
88MAPK40.50232856
89CDK190.49531779
90TAOK30.48888313
91TSSK60.48836178
92PDPK10.48825841
93NUAK10.48798134
94ATR0.48216790
95EPHB10.46750167
96ACVR1B0.46234060
97MAPK110.45800303
98CAMKK20.44493680
99IRAK10.43766770
100RPS6KL10.43091128
101RPS6KC10.43091128
102RAF10.41207953
103PTK60.40923547
104GRK70.40736003
105ALK0.40594505
106IRAK30.40136950
107CDK90.40042334
108PDK10.35236886
109MAPK70.34723579
110PIK3CG0.34088048
111MAPK120.33912126
112MAP3K80.33130634
113STK160.32879286
114BCKDK0.32559040
115MARK20.32258956
116CCNB10.31600515
117MAP3K50.31291882
118CDK60.31156488
119IRAK20.30570376
120VRK10.29717793
121PAK40.29632531
122MAPKAPK20.29275329
123PRKCD0.29227822
124FYN0.28837606
125DYRK30.28703334
126CDK70.28493776
127RPS6KA60.27962842
128ABL10.24020959
129EPHA30.23664656
130DYRK1B0.23653322
131MAPK30.22470421

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.21726367
2B cell receptor signaling pathway_Homo sapiens_hsa046622.66514906
3Antigen processing and presentation_Homo sapiens_hsa046122.65564067
4DNA replication_Homo sapiens_hsa030302.63313959
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.58686356
6T cell receptor signaling pathway_Homo sapiens_hsa046602.49785504
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.46232371
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.44447693
9Ribosome_Homo sapiens_hsa030102.33875065
10Measles_Homo sapiens_hsa051622.30956583
11Hematopoietic cell lineage_Homo sapiens_hsa046402.28763280
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.21520899
13Leishmaniasis_Homo sapiens_hsa051402.14535687
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98603050
15Mismatch repair_Homo sapiens_hsa034301.93426808
16Osteoclast differentiation_Homo sapiens_hsa043801.85819359
17Non-homologous end-joining_Homo sapiens_hsa034501.85135285
18Base excision repair_Homo sapiens_hsa034101.71204945
19Herpes simplex infection_Homo sapiens_hsa051681.67035755
20Graft-versus-host disease_Homo sapiens_hsa053321.64480729
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62433100
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62248759
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.55323784
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55291941
25Allograft rejection_Homo sapiens_hsa053301.52197919
26Acute myeloid leukemia_Homo sapiens_hsa052211.36371332
27Spliceosome_Homo sapiens_hsa030401.30701683
28Shigellosis_Homo sapiens_hsa051311.29122849
29Rheumatoid arthritis_Homo sapiens_hsa053231.28993802
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27355318
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.27246363
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22902540
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19844615
34Homologous recombination_Homo sapiens_hsa034401.18317367
35Chemokine signaling pathway_Homo sapiens_hsa040621.17829685
36Influenza A_Homo sapiens_hsa051641.14311474
37Platelet activation_Homo sapiens_hsa046111.13694948
38Viral myocarditis_Homo sapiens_hsa054161.11660184
39Other glycan degradation_Homo sapiens_hsa005111.10993008
40Hepatitis B_Homo sapiens_hsa051611.10301986
41Phagosome_Homo sapiens_hsa041451.09747560
42Nucleotide excision repair_Homo sapiens_hsa034201.09001202
43Toxoplasmosis_Homo sapiens_hsa051451.07863446
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03529107
45Apoptosis_Homo sapiens_hsa042101.03036049
46Epstein-Barr virus infection_Homo sapiens_hsa051691.02968336
47Chronic myeloid leukemia_Homo sapiens_hsa052201.01564170
48Legionellosis_Homo sapiens_hsa051340.99171133
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99083386
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96075050
51HTLV-I infection_Homo sapiens_hsa051660.94818625
52RNA degradation_Homo sapiens_hsa030180.92696136
53Pancreatic cancer_Homo sapiens_hsa052120.92513161
54Tuberculosis_Homo sapiens_hsa051520.91503523
55African trypanosomiasis_Homo sapiens_hsa051430.89108558
56Viral carcinogenesis_Homo sapiens_hsa052030.88040062
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84349634
58Colorectal cancer_Homo sapiens_hsa052100.84308710
59Cell cycle_Homo sapiens_hsa041100.82950922
60RNA polymerase_Homo sapiens_hsa030200.82502832
61Autoimmune thyroid disease_Homo sapiens_hsa053200.82320024
62Asthma_Homo sapiens_hsa053100.80627773
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80532653
64Pyrimidine metabolism_Homo sapiens_hsa002400.80436394
65Pertussis_Homo sapiens_hsa051330.79565613
66TNF signaling pathway_Homo sapiens_hsa046680.78900590
67Malaria_Homo sapiens_hsa051440.77971197
68p53 signaling pathway_Homo sapiens_hsa041150.76463976
69Non-small cell lung cancer_Homo sapiens_hsa052230.74643855
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73533054
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73211415
72Staphylococcus aureus infection_Homo sapiens_hsa051500.72695876
73Fanconi anemia pathway_Homo sapiens_hsa034600.67594932
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.66386211
75RNA transport_Homo sapiens_hsa030130.64969214
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63685553
77VEGF signaling pathway_Homo sapiens_hsa043700.63318692
78Hepatitis C_Homo sapiens_hsa051600.62404247
79Salmonella infection_Homo sapiens_hsa051320.60704979
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57623734
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56619783
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.52092045
83Proteasome_Homo sapiens_hsa030500.50788655
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49998266
85Prolactin signaling pathway_Homo sapiens_hsa049170.47826090
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47408557
87mRNA surveillance pathway_Homo sapiens_hsa030150.45815601
88Pentose phosphate pathway_Homo sapiens_hsa000300.42640221
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42611383
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.39586300
91Thyroid cancer_Homo sapiens_hsa052160.39391444
92Notch signaling pathway_Homo sapiens_hsa043300.38759910
93Renal cell carcinoma_Homo sapiens_hsa052110.38438255
94Small cell lung cancer_Homo sapiens_hsa052220.38303975
95Systemic lupus erythematosus_Homo sapiens_hsa053220.38194573
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38083399
97Inositol phosphate metabolism_Homo sapiens_hsa005620.36761814
98Choline metabolism in cancer_Homo sapiens_hsa052310.36416318
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.36280080
100N-Glycan biosynthesis_Homo sapiens_hsa005100.35643923
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35091034
102One carbon pool by folate_Homo sapiens_hsa006700.33560484
103Endocytosis_Homo sapiens_hsa041440.31706523
104Type I diabetes mellitus_Homo sapiens_hsa049400.31569217
105MAPK signaling pathway_Homo sapiens_hsa040100.30851622
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29803167
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29769511
108Endometrial cancer_Homo sapiens_hsa052130.29466629
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.29197249
110Lysosome_Homo sapiens_hsa041420.28742521
111mTOR signaling pathway_Homo sapiens_hsa041500.28448843
112Basal transcription factors_Homo sapiens_hsa030220.28025142
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27908728
114Caffeine metabolism_Homo sapiens_hsa002320.27310040
115GnRH signaling pathway_Homo sapiens_hsa049120.27278888
116FoxO signaling pathway_Homo sapiens_hsa040680.26854501
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26556129
118Insulin resistance_Homo sapiens_hsa049310.26169522
119HIF-1 signaling pathway_Homo sapiens_hsa040660.26163255
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.25785500
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25780171
122Prostate cancer_Homo sapiens_hsa052150.25156658
123Regulation of autophagy_Homo sapiens_hsa041400.23944906
124Dorso-ventral axis formation_Homo sapiens_hsa043200.22849405
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21998184
126Type II diabetes mellitus_Homo sapiens_hsa049300.15261017
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15032625
128Amoebiasis_Homo sapiens_hsa051460.14192932
129Rap1 signaling pathway_Homo sapiens_hsa040150.14066768

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