SASS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a central component of centrioles and is necessary for their duplication and function. Centrioles adopt a cartwheel-shaped structure, with the encoded protein forming the hub and spokes inside a microtubule cylinder. Defects in this gene are a cause of autosomal recessive primary microcephaly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.60292004
2protein localization to chromosome, centromeric region (GO:0071459)5.16095035
3mitotic chromosome condensation (GO:0007076)5.03340790
4mitotic metaphase plate congression (GO:0007080)4.96233800
5nuclear pore complex assembly (GO:0051292)4.70223255
6proteasome assembly (GO:0043248)4.69159228
7kinetochore organization (GO:0051383)4.61587474
8mitotic sister chromatid segregation (GO:0000070)4.59621533
9nuclear pore organization (GO:0006999)4.55278433
10kinetochore assembly (GO:0051382)4.51674958
11sister chromatid segregation (GO:0000819)4.48086871
12metaphase plate congression (GO:0051310)4.39192278
13DNA replication-independent nucleosome organization (GO:0034724)4.36246281
14DNA replication-independent nucleosome assembly (GO:0006336)4.36246281
15replication fork processing (GO:0031297)4.35827813
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.20800275
17regulation of meiosis I (GO:0060631)4.10973294
18regulation of DNA methylation (GO:0044030)4.10380139
19positive regulation of chromosome segregation (GO:0051984)4.08413591
20facial nerve structural organization (GO:0021612)4.00042975
21establishment of chromosome localization (GO:0051303)3.99992784
22telomere maintenance via semi-conservative replication (GO:0032201)3.98083248
23positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.97991793
24positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.97991793
25positive regulation of mitotic sister chromatid separation (GO:1901970)3.97991793
26DNA replication-dependent nucleosome organization (GO:0034723)3.96948038
27DNA replication-dependent nucleosome assembly (GO:0006335)3.96948038
28positive regulation of histone H3-K4 methylation (GO:0051571)3.96089447
29mitotic sister chromatid cohesion (GO:0007064)3.92618194
30ribosomal small subunit assembly (GO:0000028)3.92297477
31attachment of spindle microtubules to kinetochore (GO:0008608)3.90369238
32DNA unwinding involved in DNA replication (GO:0006268)3.87581406
33mitotic G2/M transition checkpoint (GO:0044818)3.83814422
34DNA topological change (GO:0006265)3.82566302
35spindle checkpoint (GO:0031577)3.80776472
36regulation of mitotic metaphase/anaphase transition (GO:0030071)3.75345157
37regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.75345157
38protein localization to chromosome (GO:0034502)3.75283595
39regulation of histone H3-K9 methylation (GO:0051570)3.74823259
40regulation of chromosome segregation (GO:0051983)3.68167507
41DNA deamination (GO:0045006)3.67416840
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.67294362
43mitotic nuclear envelope disassembly (GO:0007077)3.67070611
44regulation of sister chromatid segregation (GO:0033045)3.65606958
45regulation of mitotic sister chromatid separation (GO:0010965)3.65606958
46regulation of mitotic sister chromatid segregation (GO:0033047)3.65606958
47* centriole replication (GO:0007099)3.65018612
48telomere maintenance via recombination (GO:0000722)3.64242535
49chromosome segregation (GO:0007059)3.62677368
50negative regulation of chromosome segregation (GO:0051985)3.61434669
51translesion synthesis (GO:0019985)3.61155873
52negative regulation of mitotic sister chromatid separation (GO:2000816)3.60302818
53negative regulation of sister chromatid segregation (GO:0033046)3.60302818
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.60302818
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.60302818
56negative regulation of mitotic sister chromatid segregation (GO:0033048)3.60302818
57mitotic spindle checkpoint (GO:0071174)3.57094394
58regulation of centriole replication (GO:0046599)3.55712623
59chromatin assembly or disassembly (GO:0006333)3.54673951
60resolution of meiotic recombination intermediates (GO:0000712)3.51231298
61DNA replication initiation (GO:0006270)3.51121120
62pore complex assembly (GO:0046931)3.50871045
63response to folic acid (GO:0051593)3.50030593
64DNA ligation (GO:0006266)3.47298055
65meiotic cell cycle (GO:0051321)3.46835983
66regulation of centrosome cycle (GO:0046605)3.45886683
67ribosomal small subunit biogenesis (GO:0042274)3.44686562
68chromosome organization involved in meiosis (GO:0070192)3.41969553
69mitotic spindle assembly checkpoint (GO:0007094)3.41012456
70spindle assembly checkpoint (GO:0071173)3.39563200
71membrane disassembly (GO:0030397)3.38462557
72nuclear envelope disassembly (GO:0051081)3.38462557
73regulation of spindle organization (GO:0090224)3.33120100
74DNA strand elongation involved in DNA replication (GO:0006271)3.32023802
75postreplication repair (GO:0006301)3.31984766
76mitotic recombination (GO:0006312)3.29823331
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27249178
78somatic hypermutation of immunoglobulin genes (GO:0016446)3.27249178
79protein heterotetramerization (GO:0051290)3.25595820
80lymphoid progenitor cell differentiation (GO:0002320)3.21241570
81DNA strand elongation (GO:0022616)3.21033919
82telomere maintenance via telomere lengthening (GO:0010833)3.20525536
83interkinetic nuclear migration (GO:0022027)3.18456309
84purine nucleobase biosynthetic process (GO:0009113)3.18438267
85negative regulation of DNA recombination (GO:0045910)3.17403709
86superoxide anion generation (GO:0042554)3.16011024
87viral transcription (GO:0019083)3.15735890
88chromosome condensation (GO:0030261)3.12464729
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.11597285
90regulation of mitotic spindle checkpoint (GO:1903504)3.11597285
91DNA methylation involved in gamete generation (GO:0043046)3.10325734
92meiotic chromosome segregation (GO:0045132)3.09240683
93DNA double-strand break processing (GO:0000729)3.08007445
94mitotic G2 DNA damage checkpoint (GO:0007095)3.07496826
95sister chromatid cohesion (GO:0007062)3.06408069
96ATP-dependent chromatin remodeling (GO:0043044)3.06398341
97translational termination (GO:0006415)3.02954278
98protein K6-linked ubiquitination (GO:0085020)3.02730124
99meiotic cell cycle process (GO:1903046)3.01864393
100regulation of helicase activity (GO:0051095)3.01397852
101double-strand break repair via nonhomologous end joining (GO:0006303)3.01111898
102non-recombinational repair (GO:0000726)3.01111898
103negative regulation of transcription by competitive promoter binding (GO:0010944)2.99311238
104negative regulation of mitosis (GO:0045839)2.98711260
105CENP-A containing nucleosome assembly (GO:0034080)2.98164046
106mature B cell differentiation (GO:0002335)2.97174985
107regulation of DNA endoreduplication (GO:0032875)2.90195604
108maturation of SSU-rRNA (GO:0030490)2.88389295
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87613897
110postsynaptic membrane organization (GO:0001941)2.86569691
111mature B cell differentiation involved in immune response (GO:0002313)2.86206579
112regulation of double-strand break repair via homologous recombination (GO:0010569)2.85721834
113chromatin remodeling at centromere (GO:0031055)2.85586014
114regulation of nuclear cell cycle DNA replication (GO:0033262)2.84588643
115intra-S DNA damage checkpoint (GO:0031573)2.78581641
116negative regulation of execution phase of apoptosis (GO:1900118)2.75999599
117eyelid development in camera-type eye (GO:0061029)2.72661910
118SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.71432375
119respiratory chain complex IV assembly (GO:0008535)2.71398430
120cranial nerve structural organization (GO:0021604)2.71006302
121cotranslational protein targeting to membrane (GO:0006613)2.67955398
122mannosylation (GO:0097502)2.65332995
123negative regulation of viral genome replication (GO:0045071)2.65139473
124protein targeting to ER (GO:0045047)2.64271324
125endothelium development (GO:0003158)2.62894253
126GPI anchor biosynthetic process (GO:0006506)2.61351465
127axon ensheathment in central nervous system (GO:0032291)2.59383911
128central nervous system myelination (GO:0022010)2.59383911
129maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.58656555
130immunoglobulin mediated immune response (GO:0016064)2.57810587
131ribosomal large subunit biogenesis (GO:0042273)2.52594878
132amino sugar catabolic process (GO:0046348)2.51338624
133synapsis (GO:0007129)2.50851424
134cranial nerve morphogenesis (GO:0021602)2.50089411
135presynaptic membrane assembly (GO:0097105)2.49633419
136protein localization to endoplasmic reticulum (GO:0070972)2.49195394
137establishment of protein localization to endoplasmic reticulum (GO:0072599)2.48412249
138axonemal dynein complex assembly (GO:0070286)2.48362477
139purine deoxyribonucleotide catabolic process (GO:0009155)2.45299791
140regulation of pigment cell differentiation (GO:0050932)2.42466021
141somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.41145184
142somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.41145184
143isotype switching (GO:0045190)2.41145184
144nucleotide-excision repair, DNA gap filling (GO:0006297)2.40517474
145regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.40022579
146telomere organization (GO:0032200)2.39957212
147defense response to protozoan (GO:0042832)2.39924674
148GMP metabolic process (GO:0046037)2.39819269
149telomere maintenance (GO:0000723)2.39618404
150* centriole assembly (GO:0098534)2.39361894
151cytochrome complex assembly (GO:0017004)2.37147653
152androgen biosynthetic process (GO:0006702)2.36057489
153transcription from mitochondrial promoter (GO:0006390)2.35900341
154positive regulation of cellular amine metabolic process (GO:0033240)2.35420071
155microtubule depolymerization (GO:0007019)2.35122019
156histone exchange (GO:0043486)2.34416248
157positive regulation of protein kinase C signaling (GO:0090037)2.33521876
158negative regulation of nitric oxide biosynthetic process (GO:0045019)2.33478303
159DNA damage response, signal transduction resulting in transcription (GO:0042772)2.33102622
160exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.31702481
161mesonephros development (GO:0001823)2.31268364
162pseudouridine synthesis (GO:0001522)2.30429004
163DNA replication checkpoint (GO:0000076)2.30300462
164DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.29879247
165response to peptidoglycan (GO:0032494)2.27487910
166deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.27404541
167righting reflex (GO:0060013)2.26673647
168nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.26480415
169mast cell activation (GO:0045576)2.26454794
170viral genome replication (GO:0019079)2.25406855
171viral life cycle (GO:0019058)2.23827993
172nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.23614421
173C-terminal protein lipidation (GO:0006501)2.23491026
174reciprocal DNA recombination (GO:0035825)2.22333853
175reciprocal meiotic recombination (GO:0007131)2.22333853
176platelet dense granule organization (GO:0060155)2.21638778
177translational elongation (GO:0006414)2.21359393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.51689789
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.19540132
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.20447159
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.14872630
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94440009
6EZH2_22144423_ChIP-Seq_EOC_Human2.92932667
7AR_21909140_ChIP-Seq_LNCAP_Human2.73119266
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.66612753
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.63852110
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.59766477
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.58126797
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57973435
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.51517004
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.48535340
15SCL_19346495_ChIP-Seq_HPC-7_Human2.35418422
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34056096
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29329729
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25550680
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21797247
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16781894
21IRF1_19129219_ChIP-ChIP_H3396_Human2.13941553
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.12605927
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08717263
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05197427
25* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04967299
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.98302638
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.95608652
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.91878063
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.90905068
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90651437
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89881157
32* ETS1_20019798_ChIP-Seq_JURKAT_Human1.89797340
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.89678440
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.87980396
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83589939
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82591769
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.81330581
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81309822
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78563921
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77083225
41* TTF2_22483619_ChIP-Seq_HELA_Human1.72695825
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72337621
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67820411
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64579905
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.63959333
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62227042
47DCP1A_22483619_ChIP-Seq_HELA_Human1.60334549
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60160398
49* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56465833
50* MYC_18555785_ChIP-Seq_MESCs_Mouse1.56002739
51* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55902927
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55214025
53IGF1R_20145208_ChIP-Seq_DFB_Human1.55032944
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50665237
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49255810
56* GABP_17652178_ChIP-ChIP_JURKAT_Human1.48707488
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.48488004
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48327226
59FUS_26573619_Chip-Seq_HEK293_Human1.48103832
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47620977
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46756413
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46051014
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45733101
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.45429637
65ELK1_19687146_ChIP-ChIP_HELA_Human1.44600137
66RNF2_27304074_Chip-Seq_NSC_Mouse1.44532820
67STAT3_18555785_Chip-Seq_ESCs_Mouse1.41687575
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40693249
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.40593868
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.40593868
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.40593868
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38992174
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38915446
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38714454
75RUNX1_27457419_Chip-Seq_LIVER_Mouse1.37842786
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37680249
77XRN2_22483619_ChIP-Seq_HELA_Human1.35863438
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34584419
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34493814
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34300524
81EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33536054
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32113630
83NMYC_18555785_Chip-Seq_ESCs_Mouse1.30766932
84* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30547694
85P300_18555785_Chip-Seq_ESCs_Mouse1.28369928
86GABP_19822575_ChIP-Seq_HepG2_Human1.27798289
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26506473
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25728535
89* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25168388
90OCT4_18555785_Chip-Seq_ESCs_Mouse1.24360496
91IRF8_27001747_Chip-Seq_BMDM_Mouse1.23647276
92MYC_18940864_ChIP-ChIP_HL60_Human1.23076445
93TAF15_26573619_Chip-Seq_HEK293_Human1.22697135
94P53_22387025_ChIP-Seq_ESCs_Mouse1.22144811
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.20310729
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20264962
97* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20133739
98EWS_26573619_Chip-Seq_HEK293_Human1.19647911
99ZFX_18555785_Chip-Seq_ESCs_Mouse1.19311686
100* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19219227
101VDR_23849224_ChIP-Seq_CD4+_Human1.19004759
102KLF4_18555785_Chip-Seq_ESCs_Mouse1.18692969
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.18281251
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18107048
105* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17381757
106* SPI1_23547873_ChIP-Seq_NB4_Human1.17110204
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.16062369
108ESRRB_18555785_Chip-Seq_ESCs_Mouse1.15980499
109KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15602767
110* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14776787
111SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13835280
112POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13437578
113FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12692697
114ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12341796
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.11541842
116ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11474883
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.10617512
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09639958
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.09418745
120CTCF_18555785_Chip-Seq_ESCs_Mouse1.09152712
121* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09077245
122KDM5A_27292631_Chip-Seq_BREAST_Human1.08885770
123PU1_27457419_Chip-Seq_LIVER_Mouse1.06732662
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06439400
125SRF_21415370_ChIP-Seq_HL-1_Mouse1.05692603
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03654085
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02855008
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01468032
129OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99582541
130* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99352176
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99302836
132TAL1_26923725_Chip-Seq_HPCs_Mouse0.98133260
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96689838
134SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94755238
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93813705
136NANOG_16153702_ChIP-ChIP_HESCs_Human0.90212604
137SOX2_16153702_ChIP-ChIP_HESCs_Human0.89218332
138ZNF274_21170338_ChIP-Seq_K562_Hela0.89174740
139VDR_22108803_ChIP-Seq_LS180_Human0.89094652
140SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85799530
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77651567
142RBPJ_22232070_ChIP-Seq_NCS_Mouse0.72630704
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71897554
144YY1_21170310_ChIP-Seq_MESCs_Mouse0.71530882
145PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.71379066
146P300_19829295_ChIP-Seq_ESCs_Human0.70375765
147HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69537648
148EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.69008983
149TFEB_21752829_ChIP-Seq_HELA_Human0.67888110
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.66417394
151SOX17_20123909_ChIP-Seq_XEN_Mouse0.66140182
152MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.65808453
153ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.65046630
154* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.64029105
155CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.63335831
156GATA1_26923725_Chip-Seq_HPCs_Mouse0.60810160
157CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.59714431

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.43429771
2MP0005409_darkened_coat_color4.50313112
3MP0001188_hyperpigmentation3.95284112
4MP0005174_abnormal_tail_pigmentation3.74040124
5MP0000015_abnormal_ear_pigmentation3.36794236
6MP0004381_abnormal_hair_follicle3.36198495
7MP0006292_abnormal_olfactory_placode3.33288780
8MP0009379_abnormal_foot_pigmentation3.08142122
9MP0003890_abnormal_embryonic-extraembry2.79278783
10MP0003724_increased_susceptibility_to2.61996001
11MP0008057_abnormal_DNA_replication2.60955973
12MP0008058_abnormal_DNA_repair2.33453358
13MP0008789_abnormal_olfactory_epithelium2.25009687
14MP0002102_abnormal_ear_morphology2.24782537
15MP0002095_abnormal_skin_pigmentation2.22997487
16MP0009697_abnormal_copulation2.18467250
17MP0010307_abnormal_tumor_latency2.11521505
18MP0005075_abnormal_melanosome_morpholog2.10169514
19MP0002396_abnormal_hematopoietic_system2.07331703
20MP0010094_abnormal_chromosome_stability2.06685808
21MP0008260_abnormal_autophagy2.01833752
22MP0001293_anophthalmia1.90589994
23MP0005394_taste/olfaction_phenotype1.83945986
24MP0005499_abnormal_olfactory_system1.83945986
25MP0001835_abnormal_antigen_presentation1.81800088
26MP0002234_abnormal_pharynx_morphology1.81477297
27MP0003315_abnormal_perineum_morphology1.78621357
28MP0003693_abnormal_embryo_hatching1.78439495
29MP0008995_early_reproductive_senescence1.76729911
30MP0001853_heart_inflammation1.72134580
31MP0003718_maternal_effect1.72036020
32MP0000350_abnormal_cell_proliferation1.70616498
33MP0001730_embryonic_growth_arrest1.68083522
34MP0009785_altered_susceptibility_to1.63872576
35MP0001986_abnormal_taste_sensitivity1.55092736
36MP0005671_abnormal_response_to1.54363246
37MP0000490_abnormal_crypts_of1.49845952
38MP0003121_genomic_imprinting1.49317148
39MP0001697_abnormal_embryo_size1.47167852
40MP0002160_abnormal_reproductive_system1.47099480
41MP0001672_abnormal_embryogenesis/_devel1.45793886
42MP0005380_embryogenesis_phenotype1.45793886
43MP0003786_premature_aging1.45300872
44MP0000372_irregular_coat_pigmentation1.41970430
45MP0010030_abnormal_orbit_morphology1.40684788
46MP0003111_abnormal_nucleus_morphology1.40061214
47MP0005025_abnormal_response_to1.39717653
48MP0002277_abnormal_respiratory_mucosa1.36607088
49MP0002148_abnormal_hypersensitivity_rea1.36240702
50MP0003077_abnormal_cell_cycle1.35116359
51MP0002177_abnormal_outer_ear1.33973769
52MP0005000_abnormal_immune_tolerance1.31018702
53MP0003436_decreased_susceptibility_to1.30455532
54MP0002084_abnormal_developmental_patter1.27615223
55MP0002876_abnormal_thyroid_physiology1.26605952
56MP0002233_abnormal_nose_morphology1.24695881
57MP0009333_abnormal_splenocyte_physiolog1.24658557
58MP0002085_abnormal_embryonic_tissue1.22958935
59MP0000566_synostosis1.21257235
60MP0005395_other_phenotype1.18853450
61MP0002723_abnormal_immune_serum1.18448909
62MP0003699_abnormal_female_reproductive1.16851700
63MP0003303_peritoneal_inflammation1.16733894
64MP0002419_abnormal_innate_immunity1.16235275
65MP0003984_embryonic_growth_retardation1.15508408
66MP0002088_abnormal_embryonic_growth/wei1.13433861
67MP0000313_abnormal_cell_death1.13330469
68MP0001800_abnormal_humoral_immune1.12540184
69MP0000049_abnormal_middle_ear1.11691101
70MP0003763_abnormal_thymus_physiology1.10059075
71MP0002452_abnormal_antigen_presenting1.09840066
72MP0001286_abnormal_eye_development1.08635364
73MP0002420_abnormal_adaptive_immunity1.08229214
74MP0004957_abnormal_blastocyst_morpholog1.08118577
75MP0001819_abnormal_immune_cell1.07623117
76MP0004147_increased_porphyrin_level1.07542690
77MP0002249_abnormal_larynx_morphology1.06863471
78MP0002080_prenatal_lethality1.06776708
79MP0002938_white_spotting1.06469460
80MP0000631_abnormal_neuroendocrine_gland1.04944685
81MP0005464_abnormal_platelet_physiology1.04068605
82MP0001119_abnormal_female_reproductive1.03305560
83MP0002398_abnormal_bone_marrow1.02282317
84MP0002210_abnormal_sex_determination1.01845798
85MP0002161_abnormal_fertility/fecundity1.00362110
86MP0000685_abnormal_immune_system1.00232795
87MP0003938_abnormal_ear_development0.98971748
88MP0003119_abnormal_digestive_system0.98853589
89MP0002132_abnormal_respiratory_system0.98710207
90MP0008007_abnormal_cellular_replicative0.96194864
91MP0002697_abnormal_eye_size0.95458900
92MP0004197_abnormal_fetal_growth/weight/0.95101675
93MP0003806_abnormal_nucleotide_metabolis0.92490199
94MP0000681_abnormal_thyroid_gland0.92464596
95MP0000716_abnormal_immune_system0.91690898
96MP0006072_abnormal_retinal_apoptosis0.89891289
97MP0000858_altered_metastatic_potential0.87920899
98MP0002638_abnormal_pupillary_reflex0.87559338
99MP0006036_abnormal_mitochondrial_physio0.87073536
100MP0003123_paternal_imprinting0.86126356
101MP0000689_abnormal_spleen_morphology0.85938801
102MP0000465_gastrointestinal_hemorrhage0.85885227
103MP0008932_abnormal_embryonic_tissue0.85628379
104MP0005389_reproductive_system_phenotype0.85290593
105MP0003828_pulmonary_edema0.84761162
106MP0002751_abnormal_autonomic_nervous0.84693388
107MP0005451_abnormal_body_composition0.83749194
108MP0001529_abnormal_vocalization0.82929717
109MP0006035_abnormal_mitochondrial_morpho0.81779856
110MP0002086_abnormal_extraembryonic_tissu0.79678454
111MP0009672_abnormal_birth_weight0.79388183
112MP0003941_abnormal_skin_development0.79377877
113MP0002722_abnormal_immune_system0.78688423
114MP0001186_pigmentation_phenotype0.78164591
115MP0002429_abnormal_blood_cell0.78093593
116MP0004742_abnormal_vestibular_system0.77919099
117MP0001790_abnormal_immune_system0.77753679
118MP0005387_immune_system_phenotype0.77753679
119MP0005410_abnormal_fertilization0.77083782
120MP0002405_respiratory_system_inflammati0.77037663
121MP0001929_abnormal_gametogenesis0.75835070
122MP0005647_abnormal_sex_gland0.75399833
123MP0005171_absent_coat_pigmentation0.75204928
124MP0003698_abnormal_male_reproductive0.75196406
125MP0002075_abnormal_coat/hair_pigmentati0.74855086
126MP0001145_abnormal_male_reproductive0.73512142
127MP0008877_abnormal_DNA_methylation0.73424333
128MP0002111_abnormal_tail_morphology0.72730883
129MP0003567_abnormal_fetal_cardiomyocyte0.72339185
130MP0000428_abnormal_craniofacial_morphol0.70867009
131MP0002092_abnormal_eye_morphology0.70774158
132MP0003950_abnormal_plasma_membrane0.70758494
133MP0004142_abnormal_muscle_tone0.70140350
134MP0000613_abnormal_salivary_gland0.69600800
135MP0010155_abnormal_intestine_physiology0.69133732
136MP0001346_abnormal_lacrimal_gland0.67787602
137MP0003787_abnormal_imprinting0.67693724
138MP0000427_abnormal_hair_cycle0.67654506
139MP0009764_decreased_sensitivity_to0.67557233
140MP0005391_vision/eye_phenotype0.67124223
141MP0005397_hematopoietic_system_phenotyp0.66211175
142MP0001545_abnormal_hematopoietic_system0.66211175
143MP0010352_gastrointestinal_tract_polyps0.66154456
144MP0003937_abnormal_limbs/digits/tail_de0.66019213
145MP0000569_abnormal_digit_pigmentation0.65219674
146MP0003755_abnormal_palate_morphology0.64880302
147MP0003861_abnormal_nervous_system0.64614733
148MP0002009_preneoplasia0.64099953
149MP0002019_abnormal_tumor_incidence0.63770088
150MP0000026_abnormal_inner_ear0.63743077
151MP0009250_abnormal_appendicular_skeleto0.63596636
152MP0004808_abnormal_hematopoietic_stem0.63095089
153MP0009703_decreased_birth_body0.61995534
154MP0000703_abnormal_thymus_morphology0.61359123
155MP0000358_abnormal_cell_content/0.60949004
156MP0000653_abnormal_sex_gland0.60530997
157MP0003935_abnormal_craniofacial_develop0.59616672
158MP0001324_abnormal_eye_pigmentation0.58086860
159MP0005646_abnormal_pituitary_gland0.53047957
160MP0000647_abnormal_sebaceous_gland0.52909657
161MP0005253_abnormal_eye_physiology0.52553961
162MP0000762_abnormal_tongue_morphology0.51504395
163MP0005384_cellular_phenotype0.49583962
164MP0003186_abnormal_redox_activity0.49492260

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.41391261
2Type I transferrin isoform profile (HP:0003642)4.33591882
3Chromsome breakage (HP:0040012)4.29084571
4Abnormal sex determination (HP:0012244)4.21498047
5Sex reversal (HP:0012245)4.21498047
6Abnormality of secondary sexual hair (HP:0009888)4.05183472
7Abnormality of the axillary hair (HP:0100134)4.05183472
8Abnormality of the labia minora (HP:0012880)3.56380521
9Reduced antithrombin III activity (HP:0001976)3.53461138
10Oligodactyly (hands) (HP:0001180)3.37807153
11Nonprogressive disorder (HP:0003680)3.35466266
12Volvulus (HP:0002580)3.29544593
13Facial hemangioma (HP:0000329)3.28627109
14Abnormality of cells of the erythroid lineage (HP:0012130)3.24556301
15Abnormal number of erythroid precursors (HP:0012131)3.21930239
16Abnormality of the duodenum (HP:0002246)3.08056058
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.95797024
18Reticulocytopenia (HP:0001896)2.88765259
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.82071930
20Abnormal protein N-linked glycosylation (HP:0012347)2.82071930
21Abnormal protein glycosylation (HP:0012346)2.82071930
22Abnormal glycosylation (HP:0012345)2.82071930
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.78759483
24Sloping forehead (HP:0000340)2.71910105
25Abnormality of the prostate (HP:0008775)2.67899382
26Meckel diverticulum (HP:0002245)2.59983391
27Abnormality of the carotid arteries (HP:0005344)2.59501615
28Type 2 muscle fiber atrophy (HP:0003554)2.58036531
29Abnormality of the preputium (HP:0100587)2.57493299
30Impulsivity (HP:0100710)2.53427588
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.53073666
32Abnormality of the ileum (HP:0001549)2.52707243
33Absent radius (HP:0003974)2.52655771
34Abnormality of chromosome stability (HP:0003220)2.52097718
35Thyroid-stimulating hormone excess (HP:0002925)2.47848525
36Abnormal respiratory motile cilium morphology (HP:0005938)2.44993187
37Abnormal respiratory epithelium morphology (HP:0012253)2.44993187
38Absent forearm bone (HP:0003953)2.43673156
39Aplasia involving forearm bones (HP:0009822)2.43673156
40Attenuation of retinal blood vessels (HP:0007843)2.41693804
41Abnormal biliary tract physiology (HP:0012439)2.41677056
42Bile duct proliferation (HP:0001408)2.41677056
43Obstructive lung disease (HP:0006536)2.40442889
44Chronic obstructive pulmonary disease (HP:0006510)2.40442889
45Meningitis (HP:0001287)2.39158649
46Prostate neoplasm (HP:0100787)2.39043097
47Ectopic kidney (HP:0000086)2.38168670
48Nephroblastoma (Wilms tumor) (HP:0002667)2.37907444
49Oligodactyly (HP:0012165)2.37632061
50Severe visual impairment (HP:0001141)2.35588528
51Clubbing of toes (HP:0100760)2.30814747
52Supernumerary spleens (HP:0009799)2.29911885
53Median cleft lip (HP:0000161)2.29305092
54Abnormality of cochlea (HP:0000375)2.27673081
55Increased nuchal translucency (HP:0010880)2.27591870
56Muscle fiber atrophy (HP:0100295)2.26539051
57Absent/shortened dynein arms (HP:0200106)2.24734084
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.24734084
59Optic neuritis (HP:0100653)2.23905397
60Retrobulbar optic neuritis (HP:0100654)2.23905397
61Recurrent abscess formation (HP:0002722)2.23683618
62Agammaglobulinemia (HP:0004432)2.23673365
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21122047
64Elevated erythrocyte sedimentation rate (HP:0003565)2.21000747
65Short thumb (HP:0009778)2.18952654
66Embryonal renal neoplasm (HP:0011794)2.17743970
67Parakeratosis (HP:0001036)2.16314518
68Capillary hemangiomas (HP:0005306)2.16302925
69Rhabdomyosarcoma (HP:0002859)2.15942313
70Duplicated collecting system (HP:0000081)2.15240446
71Colon cancer (HP:0003003)2.13782275
72Gonadotropin excess (HP:0000837)2.12996824
73Abnormal ciliary motility (HP:0012262)2.12508780
74Gonadal dysgenesis (HP:0000133)2.11838590
75Abdominal situs inversus (HP:0003363)2.11534138
76Abnormality of abdominal situs (HP:0011620)2.11534138
77Septo-optic dysplasia (HP:0100842)2.11355691
78Aplastic anemia (HP:0001915)2.10991212
79Mediastinal lymphadenopathy (HP:0100721)2.10934622
80Stomatitis (HP:0010280)2.10890957
81Absent thumb (HP:0009777)2.06498801
82Asplenia (HP:0001746)2.06168364
83True hermaphroditism (HP:0010459)2.05361449
84Abnormality of the renal collecting system (HP:0004742)2.05164186
85Optic nerve hypoplasia (HP:0000609)2.04842603
86Male pseudohermaphroditism (HP:0000037)2.04696551
87Aplasia/Hypoplasia of the tibia (HP:0005772)2.04510792
88Horseshoe kidney (HP:0000085)2.04433405
89Abnormal respiratory motile cilium physiology (HP:0012261)2.03859402
90Pallor (HP:0000980)2.03781234
91Absent septum pellucidum (HP:0001331)2.03096984
92Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.01559963
933-Methylglutaconic aciduria (HP:0003535)2.01511765
94Hypoplastic pelvis (HP:0008839)2.01242990
95Short tibia (HP:0005736)1.99875354
96Cafe-au-lait spot (HP:0000957)1.99793462
97Medulloblastoma (HP:0002885)1.99422811
98Abnormal lung lobation (HP:0002101)1.96418241
99Cortical dysplasia (HP:0002539)1.96173332
100Combined immunodeficiency (HP:0005387)1.96100269
101Abnormality of the heme biosynthetic pathway (HP:0010472)1.95647159
102Osteomalacia (HP:0002749)1.95430057
103Abnormality of the septum pellucidum (HP:0007375)1.95313426
104Split foot (HP:0001839)1.94107212
105Myositis (HP:0100614)1.94007316
106Aplasia/Hypoplasia of the sternum (HP:0006714)1.93450418
107Megaloblastic anemia (HP:0001889)1.90763981
108Arteriovenous malformation (HP:0100026)1.90324703
109Abnormality of chromosome segregation (HP:0002916)1.90096244
110Choanal atresia (HP:0000453)1.89603405
111Triphalangeal thumb (HP:0001199)1.88688345
112Microcytic anemia (HP:0001935)1.87927908
113Bifid tongue (HP:0010297)1.87910800
114Abnormal rod and cone electroretinograms (HP:0008323)1.87047694
115Bone marrow hypocellularity (HP:0005528)1.86762942
116Abnormality of male internal genitalia (HP:0000022)1.86509336
117Macrocytic anemia (HP:0001972)1.85633592
118Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.85553787
119Aplasia/Hypoplasia of the spleen (HP:0010451)1.84685957
120Premature ovarian failure (HP:0008209)1.83980017
121Small intestinal stenosis (HP:0012848)1.83707481
122Duodenal stenosis (HP:0100867)1.83707481
123Decreased central vision (HP:0007663)1.81224535
124Eczematoid dermatitis (HP:0000976)1.79318480
125Acute myeloid leukemia (HP:0004808)1.78858911
126Embryonal neoplasm (HP:0002898)1.78831937
127Orchitis (HP:0100796)1.78706132
128Chronic mucocutaneous candidiasis (HP:0002728)1.78213394
129Recurrent cutaneous fungal infections (HP:0011370)1.78213394
130Myelodysplasia (HP:0002863)1.77872836
131Increased hepatocellular lipid droplets (HP:0006565)1.77211863
132Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75865326
133Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.75172697
134Aplasia/Hypoplasia of the earlobes (HP:0009906)1.74985852
135Neoplasm of the oral cavity (HP:0100649)1.73971878
136Hypoplasia of the radius (HP:0002984)1.73882212
137Acute lymphatic leukemia (HP:0006721)1.73825058
138Short middle phalanx of the 5th finger (HP:0004220)1.73755629
139Abnormality of the columella (HP:0009929)1.73265968
140Hypothermia (HP:0002045)1.72936676
141Duplication of thumb phalanx (HP:0009942)1.72825601
142Papillary thyroid carcinoma (HP:0002895)1.72478931
143Neoplasm of the colon (HP:0100273)1.72273254
144Abnormality of DNA repair (HP:0003254)1.72039791
145Birth length less than 3rd percentile (HP:0003561)1.71797167
146Syringomyelia (HP:0003396)1.71331594
147Spinal cord lesions (HP:0100561)1.71331594
148Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.69686176
149Abnormality of methionine metabolism (HP:0010901)1.69456505
150Limb hypertonia (HP:0002509)1.67600964
151Patellar aplasia (HP:0006443)1.67378785
152Tracheoesophageal fistula (HP:0002575)1.66579342
153Acute necrotizing encephalopathy (HP:0006965)1.64527791
154Pancreatic islet-cell hyperplasia (HP:0004510)1.63958656
155Deep philtrum (HP:0002002)1.62730816
156Preaxial hand polydactyly (HP:0001177)1.62417650
157Abnormality of the phalanges of the 5th finger (HP:0004213)1.61921500
158Abnormality of the fovea (HP:0000493)1.60592830
159B lymphocytopenia (HP:0010976)1.60554185
160Pancytopenia (HP:0001876)1.59264910
161Lip pit (HP:0100267)1.57811331
162Abnormality of midbrain morphology (HP:0002418)1.56732867
163Molar tooth sign on MRI (HP:0002419)1.56732867
164Secondary amenorrhea (HP:0000869)1.56052134
165Clitoromegaly (HP:0000057)1.55624963
166Glioma (HP:0009733)1.55355880
167Missing ribs (HP:0000921)1.54648168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.01585939
2MUSK4.81244397
3MKNK23.82237153
4TNIK3.29572033
5STK163.14123331
6MKNK12.97535908
7EIF2AK32.62780679
8NEK12.62181599
9TRIM282.52178944
10SRPK12.35923308
11NME22.27398639
12NLK2.21128079
13PLK32.20795668
14IRAK42.00049755
15PNCK1.94378115
16CLK11.92015274
17EIF2AK21.91763011
18WEE11.73630744
19YES11.71933032
20FES1.68796959
21TSSK61.67686681
22TLK11.62053306
23NUAK11.53596148
24VRK11.52153014
25TXK1.51272785
26BRAF1.51156237
27BRSK11.39529952
28CDC71.36170861
29TEC1.35352550
30VRK21.33625858
31MAP3K141.32296639
32STK31.31824940
33ZAK1.28945509
34CHEK11.25080574
35BUB11.23114730
36IRAK31.22415781
37PDK21.22406563
38CCNB11.18880123
39PLK41.18448415
40ADRBK21.16325445
41IKBKB1.16106444
42PIK3CG1.16101483
43CDK71.13199776
44CDK81.12138737
45CDK91.10242341
46TAF11.08831284
47PBK1.07681248
48DYRK31.07640840
49KIT1.07464092
50GRK10.98618329
51BLK0.98450609
52BRD40.96356675
53ACVR1B0.95311281
54STK240.95001714
55CDK120.94516476
56WNK30.91279191
57IKBKE0.87100852
58CSNK1G10.83236153
59IRAK10.82381511
60RIPK40.82213623
61BRSK20.81554732
62MET0.81038911
63EIF2AK10.80370899
64TGFBR10.79723289
65CDK30.79553067
66CDK20.79433949
67CSK0.79104224
68PHKG20.78934043
69PHKG10.78934043
70RPS6KA50.78837027
71MAP3K90.77576142
72CDK10.77169924
73BTK0.77157058
74STK40.75628631
75MAP3K80.72943674
76DYRK20.70789557
77MST40.70619298
78PLK10.70168953
79MAP3K10.69600077
80CAMK1G0.67769189
81CHEK20.67641184
82TIE10.66632307
83PIM10.65884422
84PRKCI0.65670899
85LYN0.64778011
86PRKG20.64481971
87ARAF0.64267459
88CDK190.63995423
89STK390.63789406
90MARK30.63786958
91RAF10.62862579
92PIM20.62796644
93AURKB0.62577647
94CDK40.62016002
95MELK0.60951982
96ERBB30.60224526
97RPS6KA40.59876344
98CSNK1E0.57620788
99CAMKK20.57233035
100RPS6KB20.56281461
101ATR0.55945321
102PLK20.55736173
103CAMK2B0.54952998
104MAPKAPK50.54842006
105IRAK20.54816891
106MAP2K70.53367834
107NEK20.53266168
108TAOK30.53199154
109TTK0.53196874
110PASK0.52331010
111BMPR1B0.52326311
112LATS10.52295251
113MAP4K10.52280243
114PRKD20.50195225
115PAK10.50184910
116NME10.49598351
117LCK0.49266441
118NEK60.49037700
119CSNK2A10.48746686
120HIPK20.48739363
121PKN10.46409183
122MAP3K40.46208390
123SYK0.46161966
124STK38L0.45810022
125UHMK10.45637856
126CSNK1G30.43873050
127CSF1R0.42959880
128AKT30.42833533
129MATK0.42709368
130KSR10.42512578
131WNK40.41632473
132FGR0.41375545
133AURKA0.41073248
134CSNK2A20.40764132
135BMPR20.40259186
136MAPK150.38220225
137EPHB10.37929942
138GRK70.37216930
139PRKDC0.36347660
140MAP3K100.35489003
141CSNK1A1L0.34559209
142CAMK10.33790339
143HCK0.33428814
144MAPK40.32857545
145ATM0.32659600
146CSNK1D0.30742086
147PRKG10.29847653
148CAMK2D0.29776846
149MAP3K130.28273242
150OXSR10.27525917
151ALK0.27461087
152PRKACB0.27226631
153CAMK1D0.26187422
154ERBB40.25992096
155MAPK130.25849376
156WNK10.25299979
157GSK3B0.24015974

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.64893147
2Homologous recombination_Homo sapiens_hsa034403.48686785
3Ribosome_Homo sapiens_hsa030103.40826026
4Fanconi anemia pathway_Homo sapiens_hsa034603.27097180
5Mismatch repair_Homo sapiens_hsa034302.80690723
6Non-homologous end-joining_Homo sapiens_hsa034502.80378368
7Base excision repair_Homo sapiens_hsa034102.32313755
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21987510
9RNA polymerase_Homo sapiens_hsa030202.03560867
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.00876183
11Spliceosome_Homo sapiens_hsa030401.99828456
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85716354
13Nucleotide excision repair_Homo sapiens_hsa034201.81988248
14Pyrimidine metabolism_Homo sapiens_hsa002401.79487770
15Oocyte meiosis_Homo sapiens_hsa041141.78863496
16Basal transcription factors_Homo sapiens_hsa030221.73847601
17Protein export_Homo sapiens_hsa030601.70566395
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56671796
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.56034161
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.54844819
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53641324
22Proteasome_Homo sapiens_hsa030501.49399871
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48550065
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47077894
25Graft-versus-host disease_Homo sapiens_hsa053321.44914297
26Primary immunodeficiency_Homo sapiens_hsa053401.41901006
27Cell cycle_Homo sapiens_hsa041101.41241326
28Allograft rejection_Homo sapiens_hsa053301.38863192
29Arachidonic acid metabolism_Homo sapiens_hsa005901.36514836
30Ether lipid metabolism_Homo sapiens_hsa005651.33482885
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.31896301
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31441115
33Systemic lupus erythematosus_Homo sapiens_hsa053221.29750726
34Propanoate metabolism_Homo sapiens_hsa006401.29220135
35Hematopoietic cell lineage_Homo sapiens_hsa046401.28966093
36Purine metabolism_Homo sapiens_hsa002301.28411093
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24199597
38Phototransduction_Homo sapiens_hsa047441.23224314
39RNA degradation_Homo sapiens_hsa030181.22953857
40Asthma_Homo sapiens_hsa053101.21375580
41Malaria_Homo sapiens_hsa051441.18471370
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.18400642
43p53 signaling pathway_Homo sapiens_hsa041151.17673842
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.14698400
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14271662
46Sphingolipid metabolism_Homo sapiens_hsa006001.13339073
47RNA transport_Homo sapiens_hsa030131.13251217
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13062614
49Huntingtons disease_Homo sapiens_hsa050161.12765584
50Herpes simplex infection_Homo sapiens_hsa051681.12283432
51Parkinsons disease_Homo sapiens_hsa050121.10928970
52Oxidative phosphorylation_Homo sapiens_hsa001901.08389956
53Measles_Homo sapiens_hsa051621.07109301
54Autoimmune thyroid disease_Homo sapiens_hsa053201.05881641
55Pyruvate metabolism_Homo sapiens_hsa006201.03429473
56Other glycan degradation_Homo sapiens_hsa005111.02496902
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00643884
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99519781
59Linoleic acid metabolism_Homo sapiens_hsa005910.98799312
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92177191
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90162550
62Selenocompound metabolism_Homo sapiens_hsa004500.86193564
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85834177
64Vitamin digestion and absorption_Homo sapiens_hsa049770.85529761
65One carbon pool by folate_Homo sapiens_hsa006700.84468609
66Leishmaniasis_Homo sapiens_hsa051400.83712377
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80213506
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79285865
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.76303040
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71898492
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68437291
72Caffeine metabolism_Homo sapiens_hsa002320.67289955
73Biosynthesis of amino acids_Homo sapiens_hsa012300.64868411
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63703059
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62537413
76Olfactory transduction_Homo sapiens_hsa047400.61974285
77mRNA surveillance pathway_Homo sapiens_hsa030150.60626757
78Fatty acid elongation_Homo sapiens_hsa000620.59487098
79TGF-beta signaling pathway_Homo sapiens_hsa043500.59407220
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58862329
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55960110
82Epstein-Barr virus infection_Homo sapiens_hsa051690.54568564
83N-Glycan biosynthesis_Homo sapiens_hsa005100.53296680
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52188394
85Histidine metabolism_Homo sapiens_hsa003400.51642115
86Viral carcinogenesis_Homo sapiens_hsa052030.51424865
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51362756
88Folate biosynthesis_Homo sapiens_hsa007900.50268412
89B cell receptor signaling pathway_Homo sapiens_hsa046620.49200184
90Influenza A_Homo sapiens_hsa051640.48769076
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48282772
92Steroid biosynthesis_Homo sapiens_hsa001000.47382546
93Alcoholism_Homo sapiens_hsa050340.46867195
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46411995
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46364316
96Carbon metabolism_Homo sapiens_hsa012000.46102750
97Lysine degradation_Homo sapiens_hsa003100.45776092
98MicroRNAs in cancer_Homo sapiens_hsa052060.45352938
99Alzheimers disease_Homo sapiens_hsa050100.44696606
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44134962
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43970499
102Rheumatoid arthritis_Homo sapiens_hsa053230.43947213
103Acute myeloid leukemia_Homo sapiens_hsa052210.43630365
104African trypanosomiasis_Homo sapiens_hsa051430.42861676
105TNF signaling pathway_Homo sapiens_hsa046680.41637292
106Metabolic pathways_Homo sapiens_hsa011000.41446769
107Hepatitis B_Homo sapiens_hsa051610.41436469
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41319772
109Osteoclast differentiation_Homo sapiens_hsa043800.40368337
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.40223243
111Antigen processing and presentation_Homo sapiens_hsa046120.38583800
112Pertussis_Homo sapiens_hsa051330.37987244
113ABC transporters_Homo sapiens_hsa020100.37792949
114Vitamin B6 metabolism_Homo sapiens_hsa007500.37666703
115Hippo signaling pathway_Homo sapiens_hsa043900.37285913
116Wnt signaling pathway_Homo sapiens_hsa043100.37196554
117Hedgehog signaling pathway_Homo sapiens_hsa043400.36870782
118Glutathione metabolism_Homo sapiens_hsa004800.33784657
119Hepatitis C_Homo sapiens_hsa051600.33647856
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32757420
121Chemokine signaling pathway_Homo sapiens_hsa040620.32164903
122Apoptosis_Homo sapiens_hsa042100.31707858
123Regulation of autophagy_Homo sapiens_hsa041400.30983434
124Colorectal cancer_Homo sapiens_hsa052100.30748304
125Butanoate metabolism_Homo sapiens_hsa006500.30210400
126HTLV-I infection_Homo sapiens_hsa051660.29342693
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28957613
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.28361128
129T cell receptor signaling pathway_Homo sapiens_hsa046600.27968103
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.27260935
131Prostate cancer_Homo sapiens_hsa052150.26857782
132Thyroid cancer_Homo sapiens_hsa052160.26330870
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26229816
134Type I diabetes mellitus_Homo sapiens_hsa049400.25767663
135Pathways in cancer_Homo sapiens_hsa052000.25650302
136Basal cell carcinoma_Homo sapiens_hsa052170.25273881
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.25029369
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24803185
139Ovarian steroidogenesis_Homo sapiens_hsa049130.24413716
140Fatty acid metabolism_Homo sapiens_hsa012120.20564923
141Pentose phosphate pathway_Homo sapiens_hsa000300.17596543
142Small cell lung cancer_Homo sapiens_hsa052220.14538562
143Circadian rhythm_Homo sapiens_hsa047100.13447281
144Adherens junction_Homo sapiens_hsa045200.09442846
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08879529
146Nitrogen metabolism_Homo sapiens_hsa009100.05168292
147Peroxisome_Homo sapiens_hsa041460.04586219
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.03791027
149Taste transduction_Homo sapiens_hsa047420.03584925
150Cardiac muscle contraction_Homo sapiens_hsa042600.03150155

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »