SAXO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)8.98605751
2cilium movement (GO:0003341)7.09632140
3axonemal dynein complex assembly (GO:0070286)7.05031054
4primary alcohol catabolic process (GO:0034310)6.98058912
5vitamin transmembrane transport (GO:0035461)6.56829225
6diterpenoid biosynthetic process (GO:0016102)5.99854074
7epithelial cilium movement (GO:0003351)5.83577816
8axoneme assembly (GO:0035082)5.80552791
9ethanol metabolic process (GO:0006067)5.80046844
10cilium or flagellum-dependent cell motility (GO:0001539)5.75794978
11neuron cell-cell adhesion (GO:0007158)5.09379142
12centriole assembly (GO:0098534)5.08515482
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.03800527
14response to xenobiotic stimulus (GO:0009410)5.02560150
15microtubule-based movement (GO:0007018)4.95212780
16pyrimidine-containing compound transmembrane transport (GO:0072531)4.91133528
17GTP biosynthetic process (GO:0006183)4.87308158
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.77119705
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.76438243
20one-carbon compound transport (GO:0019755)4.71010572
21cell projection assembly (GO:0030031)4.48282445
22regulation of interleukin-5 production (GO:0032674)4.44383009
23terpenoid biosynthetic process (GO:0016114)4.40215709
24ATP synthesis coupled proton transport (GO:0015986)4.38980502
25energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38980502
26lung epithelium development (GO:0060428)4.32682215
27protein localization to cilium (GO:0061512)4.31828201
28ethanol oxidation (GO:0006069)4.31531326
29tolerance induction (GO:0002507)4.30337726
30nucleoside diphosphate phosphorylation (GO:0006165)4.30206624
31presynaptic membrane assembly (GO:0097105)4.29353561
32intraciliary transport (GO:0042073)4.19193274
33retinoic acid metabolic process (GO:0042573)4.17311718
34negative regulation of T cell differentiation in thymus (GO:0033085)4.16667841
35axon ensheathment in central nervous system (GO:0032291)4.15072313
36central nervous system myelination (GO:0022010)4.15072313
37negative regulation of immunoglobulin mediated immune response (GO:0002890)4.12928942
38negative regulation of B cell mediated immunity (GO:0002713)4.12928942
39ventricular system development (GO:0021591)4.11792658
40motile cilium assembly (GO:0044458)4.11283594
41glomerular epithelial cell development (GO:0072310)4.10896993
42negative regulation of humoral immune response (GO:0002921)4.09733614
43lateral ventricle development (GO:0021670)4.04909976
44UTP biosynthetic process (GO:0006228)4.00163612
45establishment of apical/basal cell polarity (GO:0035089)3.99793391
46sperm capacitation (GO:0048240)3.98252919
47regulation of cilium movement (GO:0003352)3.95828796
48respiratory electron transport chain (GO:0022904)3.90394484
49electron transport chain (GO:0022900)3.87111699
50vocalization behavior (GO:0071625)3.86948278
51presynaptic membrane organization (GO:0097090)3.84236618
52regulation of interleukin-13 production (GO:0032656)3.78840965
53microtubule depolymerization (GO:0007019)3.75316418
54cytoplasmic microtubule organization (GO:0031122)3.75036936
55negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.72738200
56regulation of germinal center formation (GO:0002634)3.69058002
57establishment of monopolar cell polarity (GO:0061162)3.63686497
58establishment or maintenance of monopolar cell polarity (GO:0061339)3.63686497
59retinal rod cell development (GO:0046548)3.56815230
60synaptic vesicle exocytosis (GO:0016079)3.56476246
61microtubule polymerization or depolymerization (GO:0031109)3.55499988
62positive regulation of tolerance induction (GO:0002645)3.54448762
63UTP metabolic process (GO:0046051)3.53356498
64left/right axis specification (GO:0070986)3.52577002
65cilium organization (GO:0044782)3.52051750
66cilium assembly (GO:0042384)3.51926478
67exogenous drug catabolic process (GO:0042738)3.48281703
68sensory perception of smell (GO:0007608)3.40670992
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.36676915
70cilium morphogenesis (GO:0060271)3.36030397
71chaperone-mediated protein transport (GO:0072321)3.33210152
72negative regulation of inclusion body assembly (GO:0090084)3.32773905
73guanosine-containing compound biosynthetic process (GO:1901070)3.30915499
74glutathione derivative biosynthetic process (GO:1901687)3.29660188
75glutathione derivative metabolic process (GO:1901685)3.29660188
76retinol metabolic process (GO:0042572)3.28161411
77determination of left/right symmetry (GO:0007368)3.26691284
78primary alcohol metabolic process (GO:0034308)3.21327492
79neuron recognition (GO:0008038)3.20851918
80CTP biosynthetic process (GO:0006241)3.18848949
81CTP metabolic process (GO:0046036)3.18848949
82regulation of protein kinase A signaling (GO:0010738)3.17171986
83establishment of planar polarity (GO:0001736)3.15382282
84establishment of tissue polarity (GO:0007164)3.15382282
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.15271743
86determination of bilateral symmetry (GO:0009855)3.15159021
87detection of calcium ion (GO:0005513)3.13962161
88negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13057568
89gamma-aminobutyric acid signaling pathway (GO:0007214)3.12438134
90O-glycan processing (GO:0016266)3.10660078
91ATP hydrolysis coupled proton transport (GO:0015991)3.10231505
92energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.10231505
93protein localization to synapse (GO:0035418)3.07814896
94specification of symmetry (GO:0009799)3.07607292
95aldehyde catabolic process (GO:0046185)3.06404700
96transmission of nerve impulse (GO:0019226)3.05289306
97purine nucleoside triphosphate biosynthetic process (GO:0009145)3.05073752
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04944451
99protein neddylation (GO:0045116)3.03255166
100smoothened signaling pathway (GO:0007224)3.02743742
101positive regulation of smoothened signaling pathway (GO:0045880)3.02668813
102positive regulation of synapse assembly (GO:0051965)3.02150158
103centriole replication (GO:0007099)2.99424584
104postsynaptic membrane organization (GO:0001941)2.98214268
105nonmotile primary cilium assembly (GO:0035058)2.97874160
106regulation of short-term neuronal synaptic plasticity (GO:0048172)2.96304850
107photoreceptor cell maintenance (GO:0045494)2.94463778
108microtubule-based process (GO:0007017)2.94095336
109dopamine biosynthetic process (GO:0042416)2.92866649
110retinal cone cell development (GO:0046549)2.92859741
111carnitine metabolic process (GO:0009437)2.89864728
112cellular component assembly involved in morphogenesis (GO:0010927)2.89135548
113regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88702594
114lateral sprouting from an epithelium (GO:0060601)2.87707210
115protein complex biogenesis (GO:0070271)2.87527403
116response to histamine (GO:0034776)2.85168234
117neuronal action potential propagation (GO:0019227)2.84677831
118hydrogen ion transmembrane transport (GO:1902600)2.82319684
119negative regulation of neurotransmitter transport (GO:0051589)2.81091897
120organelle assembly (GO:0070925)2.79103153
121drug catabolic process (GO:0042737)2.78608336
122hydrogen peroxide biosynthetic process (GO:0050665)2.76988584
123microtubule bundle formation (GO:0001578)2.76901272
124regulation of microtubule depolymerization (GO:0031114)2.76597226
125female mating behavior (GO:0060180)2.76175822
126regulation of tolerance induction (GO:0002643)2.75549183
127axonal fasciculation (GO:0007413)2.73931715
128regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71739598
129NADH dehydrogenase complex assembly (GO:0010257)2.71669024
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71669024
131mitochondrial respiratory chain complex I assembly (GO:0032981)2.71669024
132ionotropic glutamate receptor signaling pathway (GO:0035235)2.71642541
133neuron-neuron synaptic transmission (GO:0007270)2.71541666
134dopamine transport (GO:0015872)2.70988609
135regulation of microtubule-based movement (GO:0060632)2.70272001
136substantia nigra development (GO:0021762)2.70208341
137regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69316599
138regulation of dopamine metabolic process (GO:0042053)2.68055783
139regulation of catecholamine metabolic process (GO:0042069)2.68055783
140fatty acid elongation (GO:0030497)2.67630115
141startle response (GO:0001964)2.66957408
142pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.66173562
143ribonucleoside triphosphate biosynthetic process (GO:0009201)2.66135006
144ATP biosynthetic process (GO:0006754)2.66118482
145glutamate receptor signaling pathway (GO:0007215)2.65167019
146regulation of glutamate secretion (GO:0014048)2.64170042
147sperm motility (GO:0030317)2.63995680
148regulation of autophagic vacuole assembly (GO:2000785)2.63070490
149protein polyglutamylation (GO:0018095)2.62933015
150regulation of glutamate receptor signaling pathway (GO:1900449)2.62768435
151regulation of vesicle fusion (GO:0031338)2.62165841
152positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.62029621
153long-chain fatty acid biosynthetic process (GO:0042759)2.61441923
154negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60059795
155proton transport (GO:0015992)2.59879032
156transferrin transport (GO:0033572)2.59072624
157long-term synaptic potentiation (GO:0060291)2.58365671
158photoreceptor cell differentiation (GO:0046530)2.58247585
159eye photoreceptor cell differentiation (GO:0001754)2.58247585
160positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.56992395
161hydrogen transport (GO:0006818)2.56736408
162excretion (GO:0007588)2.56574218
163mating behavior (GO:0007617)2.56532835
164apical protein localization (GO:0045176)2.55747329
165calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.50817853
166multicellular organismal water homeostasis (GO:0050891)2.49471197
167intra-S DNA damage checkpoint (GO:0031573)2.47827064
168carnitine transmembrane transport (GO:1902603)2.45987935
169reactive oxygen species biosynthetic process (GO:1903409)2.45494807
170phosphatidylcholine biosynthetic process (GO:0006656)2.43083613
171CDP-diacylglycerol biosynthetic process (GO:0016024)2.41583666
172heart looping (GO:0001947)2.41456039
173iron ion import (GO:0097286)2.38698393
174hydrogen peroxide catabolic process (GO:0042744)2.38421188
175regulation of collateral sprouting (GO:0048670)2.35719821
176regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.35545971
177protein O-linked glycosylation (GO:0006493)2.34746805
178regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.32141636
179phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.31612828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.00874529
2GBX2_23144817_ChIP-Seq_PC3_Human3.48271827
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.41834062
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.22504759
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86031971
6TAF15_26573619_Chip-Seq_HEK293_Human2.73285900
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.52760098
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41207725
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37129630
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27175951
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26460317
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24294638
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.21116564
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18694562
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15509416
16VDR_22108803_ChIP-Seq_LS180_Human2.15472359
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13301504
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.07156831
19AHR_22903824_ChIP-Seq_MCF-7_Human2.05332904
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04789045
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01438937
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.98995566
23P300_19829295_ChIP-Seq_ESCs_Human1.97068340
24FOXM1_26456572_ChIP-Seq_MCF-7_Human1.96650044
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93210882
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91834499
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91596055
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89144814
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.88508403
30FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.86263533
31FUS_26573619_Chip-Seq_HEK293_Human1.85223103
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84926455
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.83553828
34REST_21632747_ChIP-Seq_MESCs_Mouse1.82451941
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82419627
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82419627
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80850551
38SMAD4_21799915_ChIP-Seq_A2780_Human1.79379653
39RNF2_27304074_Chip-Seq_NSC_Mouse1.76559785
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75052654
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.72461887
42TP63_23658742_ChIP-Seq_EP156T_Human1.71143060
43AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.69912986
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.69599583
45ER_23166858_ChIP-Seq_MCF-7_Human1.68883274
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68124346
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62448058
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61715582
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.61209805
50AR_21572438_ChIP-Seq_LNCaP_Human1.58689501
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57857841
52ETV1_20927104_ChIP-Seq_GIST48_Human1.57736727
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57461673
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54493508
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.51808389
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.51265800
57PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.51013320
58STAT1_20625510_ChIP-Seq_HELA_Human1.50938815
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50105187
60FOXA1_25552417_ChIP-Seq_VCAP_Human1.49157576
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48945874
62PHF8_20622853_ChIP-Seq_HELA_Human1.46102896
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45638597
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.44179534
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43662077
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.43600952
67SMRT_27268052_Chip-Seq_Bcells_Human1.42044303
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41941312
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40116790
70IGF1R_20145208_ChIP-Seq_DFB_Human1.39759107
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39538350
72HNFA_21074721_ChIP-Seq_CACO-2_Human1.38025192
73CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.37532287
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.36851865
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36701423
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35053273
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34851136
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34730365
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33595544
80RBPJ_21746931_ChIP-Seq_IB4_Human1.31938021
81BCAT_22108803_ChIP-Seq_LS180_Human1.31614329
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29327387
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29035201
84RUNX1_27514584_Chip-Seq_MCF-7_Human1.28853430
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27710331
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.25891352
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24801218
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24463698
89NFYA_21822215_ChIP-Seq_K562_Human1.23412992
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23194377
91AR_25329375_ChIP-Seq_VCAP_Human1.23150150
92CBX2_22325352_ChIP-Seq_293T-Rex_Human1.23033748
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22720380
94RUNX2_22187159_ChIP-Seq_PCA_Human1.22677148
95TCF4_22108803_ChIP-Seq_LS180_Human1.22266312
96FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.21957320
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21705691
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21673514
99NFYB_21822215_ChIP-Seq_K562_Human1.21422130
100SOX2_20726797_ChIP-Seq_SW620_Human1.21322888
101KLF5_25053715_ChIP-Seq_YYC3_Human1.20898009
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20829577
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20735949
104DROSHA_22980978_ChIP-Seq_HELA_Human1.20627470
105P53_22387025_ChIP-Seq_ESCs_Mouse1.20615798
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.20039490
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.19825827
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.19454298
109JUN_21703547_ChIP-Seq_K562_Human1.19270516
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18769553
111TDRD3_21172665_ChIP-Seq_MCF-7_Human1.17705816
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.17174083
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17138509
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16773324
115TBL1_22424771_ChIP-Seq_293T_Human1.16754116
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16504322
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.16411001
118RAD21_21589869_ChIP-Seq_MESCs_Mouse1.15969141
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.15627116
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15548084
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15330371
122STAT3_23295773_ChIP-Seq_U87_Human1.14854145
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14778549
124FOXA1_25329375_ChIP-Seq_VCAP_Human1.14411316
125FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14411316
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14270849
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13535720
128SMC4_20622854_ChIP-Seq_HELA_Human1.13507048
129RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13305235
130GATA6_21074721_ChIP-Seq_CACO-2_Human1.12845736
131EWS_26573619_Chip-Seq_HEK293_Human1.12833916
132GATA4_25053715_ChIP-Seq_YYC3_Human1.12360018
133ZNF274_21170338_ChIP-Seq_K562_Hela1.11586710
134KDM2B_26808549_Chip-Seq_REH_Human1.11097189
135P300_18555785_Chip-Seq_ESCs_Mouse1.10781270
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09978786
137TCF4_23295773_ChIP-Seq_U87_Human1.09498145
138ARNT_22903824_ChIP-Seq_MCF-7_Human1.09467270
139SOX2_18555785_Chip-Seq_ESCs_Mouse1.08914552
140GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08172119
141EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08088251
142PRDM14_20953172_ChIP-Seq_ESCs_Human1.07583727
143TP53_18474530_ChIP-ChIP_U2OS_Human1.07449935
144STAT3_18555785_Chip-Seq_ESCs_Mouse1.07283820
145CDX2_20551321_ChIP-Seq_CACO-2_Human1.07130136
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06719899
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06719899
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06688652
149GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06216038
150SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06060822
151AR_20517297_ChIP-Seq_VCAP_Human1.06000847
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05110131
153CBP_20019798_ChIP-Seq_JUKART_Human1.05110131
154P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02966235
155FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02884734
156KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02680683
157TP63_22573176_ChIP-Seq_HFKS_Human1.02454125
158TP53_16413492_ChIP-PET_HCT116_Human1.01980743
159CEBPB_22108803_ChIP-Seq_LS180_Human1.01006838
160CDX2_22108803_ChIP-Seq_LS180_Human1.00947736
161TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00647819
162ESR2_21235772_ChIP-Seq_MCF-7_Human0.99684386
163GATA3_24758297_ChIP-Seq_MCF-7_Human0.97868236
164NCOR_22424771_ChIP-Seq_293T_Human0.96718724
165SMAD4_21741376_ChIP-Seq_HESCs_Human0.95485112
166SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95191335
167FOXO3_23340844_ChIP-Seq_DLD1_Human0.93929100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.96038651
2MP0002132_abnormal_respiratory_system5.13638765
3MP0003880_abnormal_central_pattern4.46113003
4MP0004043_abnormal_pH_regulation4.10673032
5MP0002277_abnormal_respiratory_mucosa3.90928760
6MP0001984_abnormal_olfaction3.60234583
7MP0001529_abnormal_vocalization3.23998161
8MP0006276_abnormal_autonomic_nervous2.82745323
9MP0009745_abnormal_behavioral_response2.72574465
10MP0001968_abnormal_touch/_nociception2.71821923
11MP0003635_abnormal_synaptic_transmissio2.71529410
12MP0002736_abnormal_nociception_after2.68871636
13MP0009046_muscle_twitch2.67473710
14MP0000383_abnormal_hair_follicle2.61758640
15MP0004859_abnormal_synaptic_plasticity2.60677883
16MP0002064_seizures2.60611053
17MP0003136_yellow_coat_color2.57846955
18MP0002272_abnormal_nervous_system2.45258111
19MP0002572_abnormal_emotion/affect_behav2.36027411
20MP0010678_abnormal_skin_adnexa2.29939847
21MP0002734_abnormal_mechanical_nocicepti2.26535220
22MP0002063_abnormal_learning/memory/cond2.26221669
23MP0005423_abnormal_somatic_nervous2.25037927
24MP0001905_abnormal_dopamine_level2.24952840
25MP0005410_abnormal_fertilization2.24916095
26MP0000566_synostosis2.20298684
27MP0005083_abnormal_biliary_tract2.19507638
28MP0001486_abnormal_startle_reflex2.19299762
29MP0001440_abnormal_grooming_behavior2.17945373
30MP0002282_abnormal_trachea_morphology2.13447596
31MP0004270_analgesia2.13160348
32MP0002735_abnormal_chemical_nociception2.09459985
33MP0004019_abnormal_vitamin_homeostasis2.06706717
34MP0000778_abnormal_nervous_system2.06255434
35MP0005645_abnormal_hypothalamus_physiol2.03708594
36MP0001501_abnormal_sleep_pattern1.98342909
37MP0002168_other_aberrant_phenotype1.89996272
38MP0004142_abnormal_muscle_tone1.87318361
39MP0003656_abnormal_erythrocyte_physiolo1.86667895
40MP0003122_maternal_imprinting1.85450069
41MP0002067_abnormal_sensory_capabilities1.83797349
42MP0005551_abnormal_eye_electrophysiolog1.80927170
43MP0005377_hearing/vestibular/ear_phenot1.77371867
44MP0003878_abnormal_ear_physiology1.77371867
45MP0001970_abnormal_pain_threshold1.70161885
46MP0001188_hyperpigmentation1.67512979
47MP0005386_behavior/neurological_phenoty1.65343781
48MP0004924_abnormal_behavior1.65343781
49MP0001765_abnormal_ion_homeostasis1.64698532
50MP0002184_abnormal_innervation1.64065008
51MP0004742_abnormal_vestibular_system1.63061664
52MP0005646_abnormal_pituitary_gland1.59468907
53MP0002733_abnormal_thermal_nociception1.58912838
54MP0002557_abnormal_social/conspecific_i1.56860206
55MP0002876_abnormal_thyroid_physiology1.56818723
56MP0005394_taste/olfaction_phenotype1.52673662
57MP0005499_abnormal_olfactory_system1.52673662
58MP0001346_abnormal_lacrimal_gland1.51339048
59MP0002822_catalepsy1.46901286
60MP0005171_absent_coat_pigmentation1.44324450
61MP0008789_abnormal_olfactory_epithelium1.42565337
62MP0005248_abnormal_Harderian_gland1.40879727
63MP0002837_dystrophic_cardiac_calcinosis1.39786668
64MP0001485_abnormal_pinna_reflex1.35721698
65MP0000678_abnormal_parathyroid_gland1.34213994
66MP0003634_abnormal_glial_cell1.34155274
67MP0002882_abnormal_neuron_morphology1.33672429
68MP0005395_other_phenotype1.33632159
69MP0000920_abnormal_myelination1.32666205
70MP0003329_amyloid_beta_deposits1.28843549
71MP0001502_abnormal_circadian_rhythm1.27936885
72MP0010234_abnormal_vibrissa_follicle1.25977723
73MP0005636_abnormal_mineral_homeostasis1.25648393
74MP0006072_abnormal_retinal_apoptosis1.24932230
75MP0001963_abnormal_hearing_physiology1.23113542
76MP0002752_abnormal_somatic_nervous1.19899764
77MP0002066_abnormal_motor_capabilities/c1.19048235
78MP0002229_neurodegeneration1.18182953
79MP0002233_abnormal_nose_morphology1.15842967
80MP0000955_abnormal_spinal_cord1.10430777
81MP0000026_abnormal_inner_ear1.09381688
82MP0005389_reproductive_system_phenotype1.07580918
83MP0005085_abnormal_gallbladder_physiolo1.06898061
84MP0002638_abnormal_pupillary_reflex1.04518834
85MP0010386_abnormal_urinary_bladder1.04349720
86MP0005408_hypopigmentation1.03960854
87MP0005379_endocrine/exocrine_gland_phen1.03617804
88MP0002249_abnormal_larynx_morphology1.01682313
89MP0002938_white_spotting1.01175407
90MP0000631_abnormal_neuroendocrine_gland1.01173066
91MP0002653_abnormal_ependyma_morphology0.99700391
92MP0002160_abnormal_reproductive_system0.99572904
93MP0001929_abnormal_gametogenesis0.98829527
94MP0005365_abnormal_bile_salt0.98254750
95MP0010030_abnormal_orbit_morphology0.97566187
96MP0005253_abnormal_eye_physiology0.97433596
97MP0002152_abnormal_brain_morphology0.96338540
98MP0005220_abnormal_exocrine_pancreas0.96193335
99MP0000372_irregular_coat_pigmentation0.91361074
100MP0003698_abnormal_male_reproductive0.91268409
101MP0005409_darkened_coat_color0.90393560
102MP0008569_lethality_at_weaning0.90003005
103MP0003633_abnormal_nervous_system0.89807574
104MP0004133_heterotaxia0.89580184
105MP0004811_abnormal_neuron_physiology0.89055960
106MP0005165_increased_susceptibility_to0.88647603
107MP0003195_calcinosis0.88045324
108MP0006292_abnormal_olfactory_placode0.86152441
109MP0001986_abnormal_taste_sensitivity0.85619755
110MP0003879_abnormal_hair_cell0.85069009
111MP0005195_abnormal_posterior_eye0.83743525
112MP0000465_gastrointestinal_hemorrhage0.83178930
113MP0003631_nervous_system_phenotype0.82168986
114MP0003787_abnormal_imprinting0.80979518
115MP0000681_abnormal_thyroid_gland0.80390230
116MP0001324_abnormal_eye_pigmentation0.80312770
117MP0002909_abnormal_adrenal_gland0.79148152
118MP0009643_abnormal_urine_homeostasis0.78037347
119MP0003890_abnormal_embryonic-extraembry0.76420632
120MP0008004_abnormal_stomach_pH0.76214908
121MP0005623_abnormal_meninges_morphology0.75815452
122MP0002928_abnormal_bile_duct0.75462771
123MP0004885_abnormal_endolymph0.75385464
124MP0002090_abnormal_vision0.74600191
125MP0009780_abnormal_chondrocyte_physiolo0.71878129
126MP0003690_abnormal_glial_cell0.70992079
127MP0001944_abnormal_pancreas_morphology0.70721115
128MP0010155_abnormal_intestine_physiology0.70266727
129MP0005310_abnormal_salivary_gland0.70217393
130MP0001943_abnormal_respiration0.69673705
131MP0001293_anophthalmia0.69182802
132MP0002136_abnormal_kidney_physiology0.69182547
133MP0002102_abnormal_ear_morphology0.68614506
134MP0004264_abnormal_extraembryonic_tissu0.67611614
135MP0001270_distended_abdomen0.67333902
136MP0008877_abnormal_DNA_methylation0.67242694
137MP0005164_abnormal_response_to0.65569873
138MP0001664_abnormal_digestion0.65429251
139MP0004134_abnormal_chest_morphology0.65241995
140MP0005391_vision/eye_phenotype0.64933551
141MP0003632_abnormal_nervous_system0.63633042
142MP0000751_myopathy0.63493114
143MP0000013_abnormal_adipose_tissue0.63462913
144MP0003121_genomic_imprinting0.63442887
145MP0003950_abnormal_plasma_membrane0.61000994
146MP0005535_abnormal_body_temperature0.60913763
147MP0008872_abnormal_physiological_respon0.60226101
148MP0002163_abnormal_gland_morphology0.59487453
149MP0009703_decreased_birth_body0.59161118
150MP0003937_abnormal_limbs/digits/tail_de0.57978169
151MP0004883_abnormal_blood_vessel0.57647318
152MP0003806_abnormal_nucleotide_metabolis0.57596825
153MP0001299_abnormal_eye_distance/0.55401069
154MP0006036_abnormal_mitochondrial_physio0.54367966
155MP0003718_maternal_effect0.53642893
156MP0009765_abnormal_xenobiotic_induced0.49911364
157MP0002116_abnormal_craniofacial_bone0.47661329
158MP0002098_abnormal_vibrissa_morphology0.46806622
159MP0002161_abnormal_fertility/fecundity0.46357491
160MP0008995_early_reproductive_senescence0.45632168
161MP0003943_abnormal_hepatobiliary_system0.41414904
162MP0002405_respiratory_system_inflammati0.41141763
163MP0002139_abnormal_hepatobiliary_system0.40970987
164MP0002135_abnormal_kidney_morphology0.40073456
165MP0000427_abnormal_hair_cycle0.39946928
166MP0005503_abnormal_tendon_morphology0.38861935
167MP0002084_abnormal_developmental_patter0.38089348

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.76123061
2Abnormal ciliary motility (HP:0012262)7.73525711
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.56756278
4Abnormal respiratory epithelium morphology (HP:0012253)6.61363177
5Abnormal respiratory motile cilium morphology (HP:0005938)6.61363177
6Rhinitis (HP:0012384)6.55777359
7Dynein arm defect of respiratory motile cilia (HP:0012255)5.80669031
8Absent/shortened dynein arms (HP:0200106)5.80669031
9Abnormality of the nasal mucosa (HP:0000433)5.32729035
10Bronchitis (HP:0012387)4.40240033
11Medial flaring of the eyebrow (HP:0010747)4.06542407
12Chronic bronchitis (HP:0004469)4.04933856
13Acute necrotizing encephalopathy (HP:0006965)3.97925187
14Gait imbalance (HP:0002141)3.92193626
15Recurrent otitis media (HP:0000403)3.81103443
16Congenital primary aphakia (HP:0007707)3.75682248
17Male infertility (HP:0003251)3.70903504
18Focal motor seizures (HP:0011153)3.52181970
19Abnormal mitochondria in muscle tissue (HP:0008316)3.50699411
20Progressive macrocephaly (HP:0004481)3.48350062
21Pancreatic fibrosis (HP:0100732)3.46167705
22Nephrogenic diabetes insipidus (HP:0009806)3.45413597
23Bronchiectasis (HP:0002110)3.44493511
24Atonic seizures (HP:0010819)3.33692011
25Genital tract atresia (HP:0001827)3.31667645
26Mitochondrial inheritance (HP:0001427)3.20101184
27True hermaphroditism (HP:0010459)3.16959214
28Vaginal atresia (HP:0000148)3.14761396
29Acute encephalopathy (HP:0006846)3.13224145
30Chronic otitis media (HP:0000389)3.00472640
31Abnormality of midbrain morphology (HP:0002418)2.96502473
32Molar tooth sign on MRI (HP:0002419)2.96502473
33Hyperactive renin-angiotensin system (HP:0000841)2.93451456
34Cystic liver disease (HP:0006706)2.91361160
35Retinal dysplasia (HP:0007973)2.89742754
36Nephronophthisis (HP:0000090)2.75697525
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.73459773
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.73459773
39Optic disc pallor (HP:0000543)2.69297433
40Myokymia (HP:0002411)2.67938632
41Limb dystonia (HP:0002451)2.64463294
42Poor coordination (HP:0002370)2.63555032
43Epileptic encephalopathy (HP:0200134)2.61622266
44Neurofibrillary tangles (HP:0002185)2.57722391
45Increased CSF lactate (HP:0002490)2.51723639
46Infertility (HP:0000789)2.41826374
47Absence seizures (HP:0002121)2.38713959
48Hyperventilation (HP:0002883)2.37625730
49Febrile seizures (HP:0002373)2.37028680
50Aplasia/Hypoplasia of the lens (HP:0008063)2.34508584
51Abnormal hair whorl (HP:0010721)2.30355462
52Hepatocellular necrosis (HP:0001404)2.27475348
53Tubulointerstitial nephritis (HP:0001970)2.25645637
54Cerebral inclusion bodies (HP:0100314)2.22476064
55Abnormality of macular pigmentation (HP:0008002)2.22302012
56Focal seizures (HP:0007359)2.21895748
57Leukodystrophy (HP:0002415)2.20589868
58Median cleft lip (HP:0000161)2.20116763
59Hypothermia (HP:0002045)2.18603337
60Pancreatic cysts (HP:0001737)2.16161236
61Occipital encephalocele (HP:0002085)2.11856829
62Progressive inability to walk (HP:0002505)2.11733405
63Chronic sinusitis (HP:0011109)2.11336714
64Dialeptic seizures (HP:0011146)2.10971766
65Progressive cerebellar ataxia (HP:0002073)2.09635749
66Abnormality of the renal medulla (HP:0100957)2.09245448
67Specific learning disability (HP:0001328)2.08600694
68Recurrent bronchitis (HP:0002837)2.06758962
69Abnormality of the corticospinal tract (HP:0002492)2.05163441
70Abnormality of dentin (HP:0010299)2.04662932
71Anencephaly (HP:0002323)2.04296638
72Visual hallucinations (HP:0002367)2.03671457
73Exercise intolerance (HP:0003546)2.03219289
74Postaxial hand polydactyly (HP:0001162)2.02437406
75Increased hepatocellular lipid droplets (HP:0006565)2.01209015
76Male pseudohermaphroditism (HP:0000037)1.96756397
77Bell-shaped thorax (HP:0001591)1.95873904
78Sensory axonal neuropathy (HP:0003390)1.94984651
79Decreased circulating renin level (HP:0003351)1.94615030
80Renal Fanconi syndrome (HP:0001994)1.94373965
81Parakeratosis (HP:0001036)1.93742212
82Postaxial foot polydactyly (HP:0001830)1.92726079
83Polyphagia (HP:0002591)1.91353079
84Cerebral edema (HP:0002181)1.90357837
85Pheochromocytoma (HP:0002666)1.89670922
86Aplasia/Hypoplasia of the tibia (HP:0005772)1.89066387
87Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.88599151
88Generalized tonic-clonic seizures (HP:0002069)1.85347993
89Short tibia (HP:0005736)1.84351427
90Broad-based gait (HP:0002136)1.82732435
91Tubular atrophy (HP:0000092)1.82025322
92Chronic hepatic failure (HP:0100626)1.81269185
933-Methylglutaconic aciduria (HP:0003535)1.80056166
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.80001647
95Amblyopia (HP:0000646)1.79984385
96Nasal polyposis (HP:0100582)1.77898604
97Furrowed tongue (HP:0000221)1.77442232
98Oculomotor apraxia (HP:0000657)1.76893609
99Scanning speech (HP:0002168)1.76377252
100Insidious onset (HP:0003587)1.76273747
101Termporal pattern (HP:0011008)1.76273747
102Asplenia (HP:0001746)1.76246953
103Renal salt wasting (HP:0000127)1.76084637
104Aplasia/Hypoplasia of the spleen (HP:0010451)1.76042237
105Metaphyseal dysplasia (HP:0100255)1.75491844
106Abnormality of glycolysis (HP:0004366)1.75095047
107Increased serum pyruvate (HP:0003542)1.75095047
108Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73358507
109Recurrent sinusitis (HP:0011108)1.72100231
110Sclerocornea (HP:0000647)1.71253191
111Absent frontal sinuses (HP:0002688)1.70722999
112Bifid tongue (HP:0010297)1.69741881
113Abnormality of renal resorption (HP:0011038)1.67303802
114Atelectasis (HP:0100750)1.66869586
115Lipid accumulation in hepatocytes (HP:0006561)1.66370823
116Neuroendocrine neoplasm (HP:0100634)1.65260766
117Nephropathy (HP:0000112)1.64850241
118Respiratory failure (HP:0002878)1.64590322
119Supernumerary spleens (HP:0009799)1.64187177
120Hyperkalemia (HP:0002153)1.64044944
121Asthma (HP:0002099)1.63837012
122Congenital hepatic fibrosis (HP:0002612)1.63437609
123Retinitis pigmentosa (HP:0000510)1.63237518
124Hyperaldosteronism (HP:0000859)1.54386955
125Abnormality of renin-angiotensin system (HP:0000847)1.42807961
126Preaxial hand polydactyly (HP:0001177)1.41746617
127Tubulointerstitial abnormality (HP:0001969)1.39748156
128Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.36613757
129Abnormality of chloride homeostasis (HP:0011422)1.33657377
130Cone-rod dystrophy (HP:0000548)1.30635451
131Abnormal rod and cone electroretinograms (HP:0008323)1.29163635
132Hypokalemic alkalosis (HP:0001949)1.27640151
133Short thorax (HP:0010306)1.25021470
134Decreased central vision (HP:0007663)1.24477717
135Abnormal drinking behavior (HP:0030082)1.21542282
136Polydipsia (HP:0001959)1.21542282
137Stage 5 chronic kidney disease (HP:0003774)1.20905250
138Abnormality of the renal cortex (HP:0011035)1.20260383
139Abnormality of the dental root (HP:0006486)1.18453798
140Taurodontia (HP:0000679)1.18453798
141Abnormality of permanent molar morphology (HP:0011071)1.18453798
142Glucose intolerance (HP:0000833)1.16808586
143Bifid scrotum (HP:0000048)1.16289623
144Hand muscle atrophy (HP:0009130)1.11456162
145Abnormal biliary tract physiology (HP:0012439)1.10121585
146Bile duct proliferation (HP:0001408)1.10121585
147Hyponatremia (HP:0002902)1.09828663
148Abnormality of the frontal sinuses (HP:0002687)1.08771035
149Abnormality of molar morphology (HP:0011070)1.08435834
150Abnormality of molar (HP:0011077)1.08435834
151Abnormality of the dental pulp (HP:0006479)1.07141165
152Fetal akinesia sequence (HP:0001989)1.05197259
153Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.04347044
154Absent speech (HP:0001344)1.04052552
155Spinal muscular atrophy (HP:0007269)0.99969586
156Tubulointerstitial fibrosis (HP:0005576)0.98952650
157Narrow forehead (HP:0000341)0.98460480
158Central scotoma (HP:0000603)0.98376047
159Prominent nasal bridge (HP:0000426)0.96883728
160Short nail (HP:0001799)0.96715856

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.20228537
2PNCK3.93894597
3CASK3.80093876
4NTRK32.94068976
5TNIK2.70251994
6MAPK152.62222434
7MAP3K122.60377132
8MST42.39755669
9ARAF2.31013552
10STK392.27440219
11OXSR12.13368819
12MAPKAPK32.02271545
13NME11.97850149
14MAPK131.93254505
15EPHA41.86819330
16BCR1.85686450
17TTK1.83403115
18MAP2K71.79528126
19GRK51.75809827
20MARK11.70406527
21MAP3K41.65393245
22PLK21.57226330
23NTRK21.51714281
24ADRBK21.49495170
25CAMK2B1.44538024
26BMPR1B1.41238232
27BMPR21.39507827
28STK161.38765941
29MAPKAPK51.33853241
30MINK11.31292831
31CDK191.30623232
32GRK71.29777581
33CAMK2A1.29576979
34EEF2K1.22482378
35WNK41.21994817
36DAPK21.21973492
37PRPF4B1.17542313
38AKT31.17518755
39RIPK41.16340516
40LIMK11.16053297
41MAP3K91.14449046
42PTK2B1.13107605
43CSNK1G31.11088989
44MAP3K31.10855596
45CAMK2D1.08540528
46CSK1.08171412
47PHKG11.07021778
48PHKG21.07021778
49GRK11.05712302
50MYLK1.05162962
51PRKCG1.04865445
52MUSK1.04760544
53BRAF1.04379087
54BRSK21.02036277
55EPHA31.00387983
56STK101.00361650
57SMG10.97344909
58EPHB10.97064412
59PRKCE0.95964744
60UHMK10.95784701
61TLK10.94617228
62CSNK1G20.93845100
63MAP3K70.93241260
64ROCK20.92610677
65FGR0.92081585
66CDK50.91070343
67MAP2K40.90437524
68CAMK2G0.89988283
69MST1R0.88887653
70PDK40.86917541
71PDK30.86917541
72MAP4K20.85850058
73ADRBK10.85129434
74ERBB30.84370846
75PRKCI0.84306434
76PKN10.83813660
77DYRK1A0.83762175
78STK38L0.83533022
79CSNK1A1L0.81724159
80LRRK20.81609654
81PAK30.78697167
82CSNK1G10.76509787
83CDK30.75573713
84PBK0.74984219
85NTRK10.74659099
86CDK140.73317998
87LATS10.72824048
88SGK2230.72255686
89SGK4940.72255686
90YES10.70620754
91STK380.69196975
92WNK30.68275909
93TESK10.67477835
94ERBB20.67334586
95CDK180.66562887
96FER0.64551594
97CDK150.61718684
98PRKD30.61377138
99NLK0.60373075
100INSRR0.59075639
101TSSK60.58034314
102PRKACA0.56987038
103WNK10.56079185
104MARK20.54858892
105CDK11A0.53888549
106VRK10.51222098
107PRKG10.50846230
108CAMKK10.50197218
109ACVR1B0.49423216
110STK240.49276034
111PDK20.49138199
112IRAK10.48414614
113DAPK10.48107574
114KSR10.46424978
115TBK10.45143560
116ERBB40.44588789
117PRKAA20.44338445
118GRK60.44187062
119NEK60.44123331
120SGK10.44042762
121PRKCQ0.43208649
122MAPK120.42694703
123TRIM280.41011666
124MAP3K20.40792500
125MOS0.40370311
126TRPM70.39895046
127FRK0.39445940
128DYRK20.38549584
129MAPK70.38234591
130FES0.38045396
131HIPK20.38024443
132SIK30.37375258
133PRKCD0.37285477
134CAMKK20.35694049
135RPS6KA20.33727034
136WEE10.33615465
137PRKCA0.32510636
138IRAK20.32244435
139MET0.32079004
140PLK10.31700323
141ROCK10.30248000
142AURKA0.29638001
143ABL10.27229266
144TAOK10.22164078
145PASK0.21740091
146STK30.20875612
147EGFR0.20571774
148RPS6KB20.19788435
149AKT20.19237986
150PRKDC0.18459313
151PDPK10.16482033
152DYRK1B0.15894209
153EIF2AK30.14924999
154CDC42BPA0.14511358

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.77747941
2Chemical carcinogenesis_Homo sapiens_hsa052044.49534575
3Phenylalanine metabolism_Homo sapiens_hsa003604.49384887
4Parkinsons disease_Homo sapiens_hsa050123.80154410
5Nicotine addiction_Homo sapiens_hsa050333.25020475
6Alzheimers disease_Homo sapiens_hsa050103.17246456
7beta-Alanine metabolism_Homo sapiens_hsa004103.14667656
8Huntingtons disease_Homo sapiens_hsa050163.02038248
9Collecting duct acid secretion_Homo sapiens_hsa049662.94460924
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.59699168
11Synaptic vesicle cycle_Homo sapiens_hsa047212.50737262
12Olfactory transduction_Homo sapiens_hsa047402.49520666
13Caffeine metabolism_Homo sapiens_hsa002322.45122372
14Retinol metabolism_Homo sapiens_hsa008302.44930551
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26282402
16GABAergic synapse_Homo sapiens_hsa047272.21888783
17Phototransduction_Homo sapiens_hsa047442.11443364
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04988309
19Cardiac muscle contraction_Homo sapiens_hsa042602.03151462
20Morphine addiction_Homo sapiens_hsa050321.98778928
21Vibrio cholerae infection_Homo sapiens_hsa051101.93589725
22Taste transduction_Homo sapiens_hsa047421.81459187
23ABC transporters_Homo sapiens_hsa020101.80481254
24Serotonergic synapse_Homo sapiens_hsa047261.74751065
25Glutamatergic synapse_Homo sapiens_hsa047241.74621330
26Amphetamine addiction_Homo sapiens_hsa050311.73021725
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.71187668
28Protein export_Homo sapiens_hsa030601.68567533
29Circadian entrainment_Homo sapiens_hsa047131.68157919
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.59133983
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58358334
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56460167
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48911799
34Dopaminergic synapse_Homo sapiens_hsa047281.47136826
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46595637
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46219624
37Peroxisome_Homo sapiens_hsa041461.43458940
38Fatty acid degradation_Homo sapiens_hsa000711.42434480
39Long-term potentiation_Homo sapiens_hsa047201.39821351
40Renin secretion_Homo sapiens_hsa049241.37264739
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32638320
42Tight junction_Homo sapiens_hsa045301.32010570
43Fatty acid elongation_Homo sapiens_hsa000621.31346144
44Circadian rhythm_Homo sapiens_hsa047101.30844596
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.29305877
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26872417
47Cocaine addiction_Homo sapiens_hsa050301.26089206
48Insulin secretion_Homo sapiens_hsa049111.23541299
49Sulfur metabolism_Homo sapiens_hsa009201.21665320
50Rheumatoid arthritis_Homo sapiens_hsa053231.19545423
51Salivary secretion_Homo sapiens_hsa049701.16815173
52Calcium signaling pathway_Homo sapiens_hsa040201.16573321
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10458727
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09028091
55Gastric acid secretion_Homo sapiens_hsa049711.04533790
56Cholinergic synapse_Homo sapiens_hsa047251.02545297
57Long-term depression_Homo sapiens_hsa047301.01086995
58Ether lipid metabolism_Homo sapiens_hsa005650.98419554
59Axon guidance_Homo sapiens_hsa043600.97675631
60Butanoate metabolism_Homo sapiens_hsa006500.94997047
61Starch and sucrose metabolism_Homo sapiens_hsa005000.91558204
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90135035
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89464734
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.86250381
65Vitamin B6 metabolism_Homo sapiens_hsa007500.85489613
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84875764
67Steroid biosynthesis_Homo sapiens_hsa001000.84357116
68Phagosome_Homo sapiens_hsa041450.84201748
69Pyruvate metabolism_Homo sapiens_hsa006200.82881082
70Sphingolipid metabolism_Homo sapiens_hsa006000.80306201
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79899540
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.78219700
73Oxytocin signaling pathway_Homo sapiens_hsa049210.75444696
74Proteasome_Homo sapiens_hsa030500.74755439
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71283415
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69602812
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68136718
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.66435730
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64520819
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.64410084
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63885681
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61505592
83Melanogenesis_Homo sapiens_hsa049160.60458880
84cAMP signaling pathway_Homo sapiens_hsa040240.60434837
85GnRH signaling pathway_Homo sapiens_hsa049120.59522093
86Tryptophan metabolism_Homo sapiens_hsa003800.56227356
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53975381
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53596037
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.52943060
90Regulation of autophagy_Homo sapiens_hsa041400.51538150
91Ovarian steroidogenesis_Homo sapiens_hsa049130.51110982
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50954568
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50391692
94Gap junction_Homo sapiens_hsa045400.50017931
95Metabolic pathways_Homo sapiens_hsa011000.46971193
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46197137
97Estrogen signaling pathway_Homo sapiens_hsa049150.45716260
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44420070
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43862355
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42727938
101Choline metabolism in cancer_Homo sapiens_hsa052310.42388202
102Alcoholism_Homo sapiens_hsa050340.41325965
103Thyroid hormone synthesis_Homo sapiens_hsa049180.40401679
104PPAR signaling pathway_Homo sapiens_hsa033200.39414107
105Nitrogen metabolism_Homo sapiens_hsa009100.39285652
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.38822264
107Arachidonic acid metabolism_Homo sapiens_hsa005900.37823664
108Hepatitis C_Homo sapiens_hsa051600.36949087
109Type I diabetes mellitus_Homo sapiens_hsa049400.35909481
110Purine metabolism_Homo sapiens_hsa002300.35164066
111Tyrosine metabolism_Homo sapiens_hsa003500.35068812
112Pancreatic secretion_Homo sapiens_hsa049720.34212580
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33890480
114Adherens junction_Homo sapiens_hsa045200.33557703
115Complement and coagulation cascades_Homo sapiens_hsa046100.32832328
116Hematopoietic cell lineage_Homo sapiens_hsa046400.31714283
117Histidine metabolism_Homo sapiens_hsa003400.31119301
118Autoimmune thyroid disease_Homo sapiens_hsa053200.30264127
119Hedgehog signaling pathway_Homo sapiens_hsa043400.29556456
120Wnt signaling pathway_Homo sapiens_hsa043100.29421202
121Dorso-ventral axis formation_Homo sapiens_hsa043200.28918686
122Arginine and proline metabolism_Homo sapiens_hsa003300.27683797
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27679059
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27604202
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27178176
126Vitamin digestion and absorption_Homo sapiens_hsa049770.26988779
127Propanoate metabolism_Homo sapiens_hsa006400.26944439
128Ras signaling pathway_Homo sapiens_hsa040140.26614963
129ErbB signaling pathway_Homo sapiens_hsa040120.26207069
130Basal cell carcinoma_Homo sapiens_hsa052170.25449787
131Dilated cardiomyopathy_Homo sapiens_hsa054140.25434121
132Linoleic acid metabolism_Homo sapiens_hsa005910.25129329
133Prion diseases_Homo sapiens_hsa050200.24859364
134Glycerolipid metabolism_Homo sapiens_hsa005610.24635009
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24547340
136Glutathione metabolism_Homo sapiens_hsa004800.22492764
137MAPK signaling pathway_Homo sapiens_hsa040100.22210952
138Basal transcription factors_Homo sapiens_hsa030220.22162575
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21467609
140African trypanosomiasis_Homo sapiens_hsa051430.20752045
141Oocyte meiosis_Homo sapiens_hsa041140.20594446
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20263175
143Mineral absorption_Homo sapiens_hsa049780.20090950
144Notch signaling pathway_Homo sapiens_hsa043300.18446295
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16504077
146Hippo signaling pathway_Homo sapiens_hsa043900.15829992
147Asthma_Homo sapiens_hsa053100.15435489
148Glycosaminoglycan degradation_Homo sapiens_hsa005310.14377736
149Lysosome_Homo sapiens_hsa041420.14245439
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13357639
151Fatty acid biosynthesis_Homo sapiens_hsa000610.12057921
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.10964554

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