SAYSD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule metabolic process (GO:0044036)6.51657050
2cell wall macromolecule catabolic process (GO:0016998)6.51657050
3sperm motility (GO:0030317)6.29434738
4DNA deamination (GO:0045006)5.92830678
5fusion of sperm to egg plasma membrane (GO:0007342)5.90546542
6sperm-egg recognition (GO:0035036)5.65387244
7acrosome reaction (GO:0007340)5.61640000
8axonemal dynein complex assembly (GO:0070286)5.48677326
9epithelial cilium movement (GO:0003351)5.46565653
10multicellular organism reproduction (GO:0032504)5.22698536
11motile cilium assembly (GO:0044458)5.15463472
12binding of sperm to zona pellucida (GO:0007339)5.13533577
13regulation of cilium movement (GO:0003352)5.02663051
14cell-cell recognition (GO:0009988)5.01761117
15ubiquinone biosynthetic process (GO:0006744)4.91003358
16GTP biosynthetic process (GO:0006183)4.78105871
17acrosome assembly (GO:0001675)4.62018845
18cilium or flagellum-dependent cell motility (GO:0001539)4.59200670
19ubiquinone metabolic process (GO:0006743)4.58784199
20spermatid development (GO:0007286)4.56973398
21cilium movement (GO:0003341)4.46739294
22plasma membrane fusion (GO:0045026)4.35452316
23pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.34367969
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.31109269
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.27744780
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.27744780
27energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21980660
28ATP synthesis coupled proton transport (GO:0015986)4.21980660
29reproduction (GO:0000003)4.15851321
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.10512360
31mannosylation (GO:0097502)4.07051556
32UTP biosynthetic process (GO:0006228)3.98129867
33quinone biosynthetic process (GO:1901663)3.97182644
34ribosomal small subunit assembly (GO:0000028)3.93100445
35guanosine-containing compound biosynthetic process (GO:1901070)3.87447787
36sequestering of actin monomers (GO:0042989)3.84856198
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.81784896
38termination of RNA polymerase III transcription (GO:0006386)3.81784896
39kinetochore assembly (GO:0051382)3.81087497
40protein complex biogenesis (GO:0070271)3.76300052
41single fertilization (GO:0007338)3.67692038
42oxidative phosphorylation (GO:0006119)3.67087286
43water-soluble vitamin biosynthetic process (GO:0042364)3.64981971
44C-terminal protein lipidation (GO:0006501)3.64051157
45signal peptide processing (GO:0006465)3.63098884
46respiratory electron transport chain (GO:0022904)3.59995502
47proteasome assembly (GO:0043248)3.58967852
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.58333098
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.58333098
50NADH dehydrogenase complex assembly (GO:0010257)3.58333098
51electron transport chain (GO:0022900)3.57442268
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.55586454
53pyrimidine nucleotide catabolic process (GO:0006244)3.55379113
54microtubule depolymerization (GO:0007019)3.51608850
55mitochondrial respiratory chain complex assembly (GO:0033108)3.49918225
56sperm capacitation (GO:0048240)3.48540206
57CTP biosynthetic process (GO:0006241)3.46236532
58CTP metabolic process (GO:0046036)3.46236532
59UTP metabolic process (GO:0046051)3.42451732
60C-terminal protein amino acid modification (GO:0018410)3.38119644
61single strand break repair (GO:0000012)3.36587847
62ribosomal small subunit biogenesis (GO:0042274)3.34364740
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33227731
64pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.31290124
65respiratory chain complex IV assembly (GO:0008535)3.30342715
66preassembly of GPI anchor in ER membrane (GO:0016254)3.29526434
67nucleoside diphosphate phosphorylation (GO:0006165)3.28639019
68protein targeting to mitochondrion (GO:0006626)3.27337843
69piRNA metabolic process (GO:0034587)3.24448522
70rRNA modification (GO:0000154)3.22239477
71negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21995095
72pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.18943004
73intraciliary transport (GO:0042073)3.18404657
74negative regulation of cAMP-mediated signaling (GO:0043951)3.18146067
75dopamine transport (GO:0015872)3.17119593
76regulation of helicase activity (GO:0051095)3.16650357
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16649786
78GPI anchor metabolic process (GO:0006505)3.16470513
79centriole assembly (GO:0098534)3.11536457
80cytochrome complex assembly (GO:0017004)3.10217882
81establishment of protein localization to mitochondrion (GO:0072655)3.07609354
82rRNA methylation (GO:0031167)3.05196848
83regulation of meiosis I (GO:0060631)3.04207817
84male meiosis (GO:0007140)3.02876082
85spermatid nucleus differentiation (GO:0007289)3.02597836
86nucleotide transmembrane transport (GO:1901679)3.01742112
87deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.01725146
88glycerol ether metabolic process (GO:0006662)3.01472279
89kinetochore organization (GO:0051383)3.01327349
90spermatogenesis (GO:0007283)3.00546066
91male gamete generation (GO:0048232)3.00340623
92organic cation transport (GO:0015695)2.99796313
93L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99687838
94protein localization to mitochondrion (GO:0070585)2.98430729
95positive regulation of mitochondrial fission (GO:0090141)2.98253178
96regulation of mitochondrial translation (GO:0070129)2.96440343
97pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.96378751
98base-excision repair, AP site formation (GO:0006285)2.94666108
99SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94638957
100pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.94420086
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93738732
102negative regulation of ligase activity (GO:0051352)2.93738732
103protein targeting to ER (GO:0045047)2.91496624
104cotranslational protein targeting to membrane (GO:0006613)2.91268154
105autophagic vacuole fusion (GO:0000046)2.90902279
106nucleoside diphosphate catabolic process (GO:0009134)2.90442080
107cullin deneddylation (GO:0010388)2.89766465
108ether metabolic process (GO:0018904)2.89689309
109anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88787484
110telomere maintenance via semi-conservative replication (GO:0032201)2.87386587
111fertilization (GO:0009566)2.85778504
112transcription from mitochondrial promoter (GO:0006390)2.85273622
113replication fork processing (GO:0031297)2.84416904
114protein localization to endoplasmic reticulum (GO:0070972)2.83612623
115dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.83074405
116centriole replication (GO:0007099)2.81297772
117ribosomal large subunit biogenesis (GO:0042273)2.81126042
118signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80917061
119intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80917061
120DNA damage response, detection of DNA damage (GO:0042769)2.79174771
121DNA catabolic process, exonucleolytic (GO:0000738)2.78258442
122gamete generation (GO:0007276)2.78060113
123synaptonemal complex organization (GO:0070193)2.77667503
124deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.77386316
125peptidyl-histidine modification (GO:0018202)2.76767367
126iron-sulfur cluster assembly (GO:0016226)2.76286925
127metallo-sulfur cluster assembly (GO:0031163)2.76286925
128short-chain fatty acid metabolic process (GO:0046459)2.76182288
129reciprocal meiotic recombination (GO:0007131)2.75974311
130reciprocal DNA recombination (GO:0035825)2.75974311
131chaperone-mediated protein transport (GO:0072321)2.75627664
132mitochondrion morphogenesis (GO:0070584)2.75022023
133branched-chain amino acid catabolic process (GO:0009083)2.74911612
134mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.74530768
135maturation of 5.8S rRNA (GO:0000460)2.74147553
136signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73186203
137signal transduction involved in DNA damage checkpoint (GO:0072422)2.73186203
1387-methylguanosine RNA capping (GO:0009452)2.72593799
139RNA capping (GO:0036260)2.72593799
140signal transduction involved in cell cycle checkpoint (GO:0072395)2.72445091
1417-methylguanosine mRNA capping (GO:0006370)2.72418296
142antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72081134
143exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72057628
144positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.71782697
145establishment of protein localization to endoplasmic reticulum (GO:0072599)2.71185141
146nucleoside diphosphate metabolic process (GO:0009132)2.70910250
147organelle disassembly (GO:1903008)2.70618657
148heme biosynthetic process (GO:0006783)2.70563320
149amyloid precursor protein catabolic process (GO:0042987)2.70256087
150protein deneddylation (GO:0000338)2.70218559
151purine nucleoside triphosphate biosynthetic process (GO:0009145)2.69805767
152positive regulation of ligase activity (GO:0051351)2.69061797
153regulation of cellular amino acid metabolic process (GO:0006521)2.68548439
154DNA methylation involved in gamete generation (GO:0043046)2.68259455
155GPI anchor biosynthetic process (GO:0006506)2.67840304
156deoxyribonucleotide catabolic process (GO:0009264)2.67779739
157nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67077855
158anterograde synaptic vesicle transport (GO:0048490)2.66968285
159purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.66768441
160quinone metabolic process (GO:1901661)2.65644005
161protein-cofactor linkage (GO:0018065)2.65304408
162telomere maintenance via recombination (GO:0000722)2.65177942
163signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.64981409
164signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.64981409
165signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.64981409
166ATP biosynthetic process (GO:0006754)2.64694221
167viral transcription (GO:0019083)2.64190046
168DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63866956
169kynurenine metabolic process (GO:0070189)2.63759909
170deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.63339351
171resolution of meiotic recombination intermediates (GO:0000712)2.62860074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.78729867
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.02142487
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.97152435
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.76039614
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.29587371
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.25486658
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04254522
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.98455496
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.85485684
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74122670
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45253252
12SRF_21415370_ChIP-Seq_HL-1_Mouse2.44518443
13VDR_22108803_ChIP-Seq_LS180_Human2.34508287
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.27651995
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21886210
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.17297612
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04692644
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04097402
19VDR_23849224_ChIP-Seq_CD4+_Human2.01429040
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98812651
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.95577910
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93032607
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.91808691
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89930336
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.88718732
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88375773
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87760061
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84922723
29ZNF274_21170338_ChIP-Seq_K562_Hela1.81998052
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78489974
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67217175
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.65931950
33FOXP3_21729870_ChIP-Seq_TREG_Human1.65840578
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64786640
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64444060
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63144654
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56518138
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56346322
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54167708
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53311219
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49723525
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48630366
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46887528
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46208917
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.43349514
46DCP1A_22483619_ChIP-Seq_HELA_Human1.42674253
47IRF1_19129219_ChIP-ChIP_H3396_Human1.42332641
48IGF1R_20145208_ChIP-Seq_DFB_Human1.41533442
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.40782095
50ELK1_19687146_ChIP-ChIP_HELA_Human1.40560704
51TP53_22573176_ChIP-Seq_HFKS_Human1.40358213
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.38661488
53EWS_26573619_Chip-Seq_HEK293_Human1.36910859
54KDM5A_27292631_Chip-Seq_BREAST_Human1.34516353
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33891149
56E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33658713
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32004266
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27707721
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27423338
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26128916
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.26128916
62TTF2_22483619_ChIP-Seq_HELA_Human1.26021918
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25849698
64GABP_19822575_ChIP-Seq_HepG2_Human1.25836835
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22395799
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22163329
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22004231
68TFEB_21752829_ChIP-Seq_HELA_Human1.17992817
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16274059
70XRN2_22483619_ChIP-Seq_HELA_Human1.14486683
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14354270
72CIITA_25753668_ChIP-Seq_RAJI_Human1.14252385
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12938267
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12833919
75GATA3_21867929_ChIP-Seq_CD8_Mouse1.12610657
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12439118
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12341841
78SOX2_22085726_ChIP-Seq_NPCs_Mouse1.12271458
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10978944
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10397367
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09697351
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09525893
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.08624485
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07834373
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07257575
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07091119
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06998775
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06739004
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05419273
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05044868
91AR_20517297_ChIP-Seq_VCAP_Human1.04699871
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03404195
93E2F7_22180533_ChIP-Seq_HELA_Human1.03001058
94CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02176678
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.01958469
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.00211274
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.99703445
98MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98931711
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.98555844
100STAT1_17558387_ChIP-Seq_HELA_Human0.97277098
101ERG_20517297_ChIP-Seq_VCAP_Human0.97165752
102STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96853102
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96654300
104ELK1_22589737_ChIP-Seq_MCF10A_Human0.96240783
105FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96120981
106GATA3_21867929_ChIP-Seq_TH1_Mouse0.95311662
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95152418
108ER_23166858_ChIP-Seq_MCF-7_Human0.94430918
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94214937
110IRF8_21731497_ChIP-ChIP_J774_Mouse0.93971074
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93889608
112ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93757462
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93490531
114P53_22387025_ChIP-Seq_ESCs_Mouse0.93389623
115SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93164356
116NANOG_20526341_ChIP-Seq_ESCs_Human0.92724790
117STAT1_20625510_ChIP-Seq_HELA_Human0.92450932
118OCT4_18555785_Chip-Seq_ESCs_Mouse0.92349361
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92288477
120P300_18555785_Chip-Seq_ESCs_Mouse0.91759123
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91454258
122MYC_18940864_ChIP-ChIP_HL60_Human0.91036531
123NMYC_18555785_Chip-Seq_ESCs_Mouse0.91004622
124ZFX_18555785_Chip-Seq_ESCs_Mouse0.90899244
125MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90642421
126GATA3_26560356_Chip-Seq_TH1_Human0.90497432
127E2F1_21310950_ChIP-Seq_MCF-7_Human0.90476428
128KLF4_18555785_Chip-Seq_ESCs_Mouse0.89966249
129RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89800756
130HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89796412
131LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89422397
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88662529
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88571655
134E2F4_17652178_ChIP-ChIP_JURKAT_Human0.88361759
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87932747
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87427091
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83757461
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82010597
139NCOR_22424771_ChIP-Seq_293T_Human0.79829891
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79172379
141NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78875452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.50912976
2MP0001986_abnormal_taste_sensitivity2.88385986
3MP0009379_abnormal_foot_pigmentation2.83945877
4MP0003698_abnormal_male_reproductive2.76373610
5MP0003806_abnormal_nucleotide_metabolis2.75312624
6MP0001929_abnormal_gametogenesis2.74837503
7MP0008877_abnormal_DNA_methylation2.66606803
8MP0002132_abnormal_respiratory_system2.63003471
9MP0008058_abnormal_DNA_repair2.63000649
10MP0006292_abnormal_olfactory_placode2.45504792
11MP0006035_abnormal_mitochondrial_morpho2.42114707
12MP0002837_dystrophic_cardiac_calcinosis2.20970209
13MP0003136_yellow_coat_color2.06757924
14MP0005075_abnormal_melanosome_morpholog2.04709158
15MP0001835_abnormal_antigen_presentation1.95108917
16MP0002210_abnormal_sex_determination1.91525302
17MP0002163_abnormal_gland_morphology1.83735408
18MP0002234_abnormal_pharynx_morphology1.82962788
19MP0003111_abnormal_nucleus_morphology1.82898447
20MP0005379_endocrine/exocrine_gland_phen1.78698094
21MP0001764_abnormal_homeostasis1.77105381
22MP0002148_abnormal_hypersensitivity_rea1.75462920
23MP0003724_increased_susceptibility_to1.73264920
24MP0001188_hyperpigmentation1.71252424
25MP0003763_abnormal_thymus_physiology1.71148458
26MP0002277_abnormal_respiratory_mucosa1.70494383
27MP0009697_abnormal_copulation1.69071745
28MP0003186_abnormal_redox_activity1.67934246
29MP0003693_abnormal_embryo_hatching1.66929846
30MP0002909_abnormal_adrenal_gland1.65535142
31MP0003880_abnormal_central_pattern1.64377051
32MP0008057_abnormal_DNA_replication1.62464921
33MP0005671_abnormal_response_to1.62108589
34MP0001145_abnormal_male_reproductive1.59517834
35MP0009785_altered_susceptibility_to1.58575931
36MP0010386_abnormal_urinary_bladder1.58234071
37MP0002160_abnormal_reproductive_system1.57542591
38MP0004381_abnormal_hair_follicle1.55876574
39MP0002736_abnormal_nociception_after1.53580894
40MP0002822_catalepsy1.53485543
41MP0000566_synostosis1.51815772
42MP0001919_abnormal_reproductive_system1.49089360
43MP0003283_abnormal_digestive_organ1.49015686
44MP0000427_abnormal_hair_cycle1.47773075
45MP0003786_premature_aging1.45881173
46MP0000358_abnormal_cell_content/1.42772460
47MP0000653_abnormal_sex_gland1.42768956
48MP0000372_irregular_coat_pigmentation1.42420580
49MP0002161_abnormal_fertility/fecundity1.41215415
50MP0000015_abnormal_ear_pigmentation1.37805345
51MP0009046_muscle_twitch1.37387480
52MP0000569_abnormal_digit_pigmentation1.36901266
53MP0003123_paternal_imprinting1.36739681
54MP0000678_abnormal_parathyroid_gland1.35569533
55MP0003195_calcinosis1.33714885
56MP0004142_abnormal_muscle_tone1.33290743
57MP0010094_abnormal_chromosome_stability1.32007250
58MP0003172_abnormal_lysosome_physiology1.30540108
59MP0002102_abnormal_ear_morphology1.29007331
60MP0002938_white_spotting1.28305867
61MP0005670_abnormal_white_adipose1.27761238
62MP0005084_abnormal_gallbladder_morpholo1.23808648
63MP0003183_abnormal_peptide_metabolism1.23370808
64MP0005646_abnormal_pituitary_gland1.20336665
65MP0003718_maternal_effect1.18787474
66MP0008007_abnormal_cellular_replicative1.18603830
67MP0005000_abnormal_immune_tolerance1.16466660
68MP0006072_abnormal_retinal_apoptosis1.16302627
69MP0005025_abnormal_response_to1.16278029
70MP0004742_abnormal_vestibular_system1.15381213
71MP0002876_abnormal_thyroid_physiology1.14720952
72MP0003315_abnormal_perineum_morphology1.14322018
73MP0005636_abnormal_mineral_homeostasis1.14307521
74MP0003787_abnormal_imprinting1.13216777
75MP0005319_abnormal_enzyme/_coenzyme1.10944960
76MP0002723_abnormal_immune_serum1.09497870
77MP0005332_abnormal_amino_acid1.09052854
78MP0005058_abnormal_lysosome_morphology1.08836804
79MP0005389_reproductive_system_phenotype1.06099807
80MP0004782_abnormal_surfactant_physiolog1.04410638
81MP0001800_abnormal_humoral_immune1.03740285
82MP0005266_abnormal_metabolism1.03684663
83MP0006036_abnormal_mitochondrial_physio1.02190923
84MP0002405_respiratory_system_inflammati1.01584119
85MP0001905_abnormal_dopamine_level1.00511834
86MP0005551_abnormal_eye_electrophysiolog1.00495707
87MP0002638_abnormal_pupillary_reflex0.99618454
88MP0005174_abnormal_tail_pigmentation0.99321912
89MP0000685_abnormal_immune_system0.98426095
90MP0002420_abnormal_adaptive_immunity0.98004695
91MP0005387_immune_system_phenotype0.97825744
92MP0001790_abnormal_immune_system0.97825744
93MP0001542_abnormal_bone_strength0.97258366
94MP0002452_abnormal_antigen_presenting0.96716748
95MP0000049_abnormal_middle_ear0.96508420
96MP0001819_abnormal_immune_cell0.96079012
97MP0000613_abnormal_salivary_gland0.95765075
98MP0000538_abnormal_urinary_bladder0.94091897
99MP0000681_abnormal_thyroid_gland0.94019513
100MP0003656_abnormal_erythrocyte_physiolo0.93085780
101MP0001853_heart_inflammation0.92654434
102MP0000490_abnormal_crypts_of0.91990658
103MP0005409_darkened_coat_color0.90839146
104MP0002419_abnormal_innate_immunity0.90644879
105MP0003011_delayed_dark_adaptation0.90069448
106MP0004147_increased_porphyrin_level0.89897046
107MP0002095_abnormal_skin_pigmentation0.89393133
108MP0001944_abnormal_pancreas_morphology0.88873661
109MP0001968_abnormal_touch/_nociception0.88306136
110MP0003436_decreased_susceptibility_to0.87259175
111MP0005171_absent_coat_pigmentation0.85781217
112MP0009780_abnormal_chondrocyte_physiolo0.84960898
113MP0001873_stomach_inflammation0.83257898
114MP0002396_abnormal_hematopoietic_system0.82863732
115MP0003077_abnormal_cell_cycle0.82780178
116MP0008932_abnormal_embryonic_tissue0.81312778
117MP0004133_heterotaxia0.80354102
118MP0004957_abnormal_blastocyst_morpholog0.79415417
119MP0000647_abnormal_sebaceous_gland0.79382920
120MP0008260_abnormal_autophagy0.79040099
121MP0009333_abnormal_splenocyte_physiolog0.78975774
122MP0000716_abnormal_immune_system0.78882025
123MP0000689_abnormal_spleen_morphology0.78762100
124MP0001984_abnormal_olfaction0.78695837
125MP0002693_abnormal_pancreas_physiology0.78238058
126MP0002933_joint_inflammation0.78226771
127MP0005499_abnormal_olfactory_system0.77361027
128MP0005394_taste/olfaction_phenotype0.77361027
129MP0002398_abnormal_bone_marrow0.77155583
130MP0004233_abnormal_muscle_weight0.76397143
131MP0002653_abnormal_ependyma_morphology0.76131242
132MP0002067_abnormal_sensory_capabilities0.76021509
133MP0003890_abnormal_embryonic-extraembry0.75751374
134MP0006276_abnormal_autonomic_nervous0.75348528
135MP0005395_other_phenotype0.75259910
136MP0001119_abnormal_female_reproductive0.74968089
137MP0008789_abnormal_olfactory_epithelium0.74858570
138MP0005408_hypopigmentation0.74835023
139MP0002229_neurodegeneration0.74729262
140MP0005645_abnormal_hypothalamus_physiol0.74457431
141MP0006082_CNS_inflammation0.74381179
142MP0008995_early_reproductive_senescence0.74372205
143MP0004134_abnormal_chest_morphology0.73501070
144MP0003567_abnormal_fetal_cardiomyocyte0.72585908
145MP0004924_abnormal_behavior0.71767337
146MP0005386_behavior/neurological_phenoty0.71767337
147MP0009764_decreased_sensitivity_to0.71001124
148MP0005365_abnormal_bile_salt0.70544709
149MP0005253_abnormal_eye_physiology0.69264780
150MP0002078_abnormal_glucose_homeostasis0.69220482
151MP0005647_abnormal_sex_gland0.67846779
152MP0000703_abnormal_thymus_morphology0.66277695

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)6.26812071
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.26812071
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.96987324
4Abnormal respiratory epithelium morphology (HP:0012253)5.24511801
5Abnormal respiratory motile cilium morphology (HP:0005938)5.24511801
6Abnormal respiratory motile cilium physiology (HP:0012261)4.82563141
7Abnormal ciliary motility (HP:0012262)4.23482925
8Chronic bronchitis (HP:0004469)3.75572642
93-Methylglutaconic aciduria (HP:0003535)3.69945975
10Rhinitis (HP:0012384)3.67348345
11Microretrognathia (HP:0000308)3.49584806
12Acute necrotizing encephalopathy (HP:0006965)3.26876790
13Mitochondrial inheritance (HP:0001427)3.22129011
14Ketoacidosis (HP:0001993)3.05028010
15Methylmalonic acidemia (HP:0002912)2.97963874
16Type I transferrin isoform profile (HP:0003642)2.96601066
17Renal Fanconi syndrome (HP:0001994)2.89517050
18Increased hepatocellular lipid droplets (HP:0006565)2.88861038
19Hepatocellular necrosis (HP:0001404)2.88690470
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.86549692
21Bronchiectasis (HP:0002110)2.85756897
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.84492525
23Medial flaring of the eyebrow (HP:0010747)2.83884826
24Abnormal mitochondria in muscle tissue (HP:0008316)2.83343225
25Methylmalonic aciduria (HP:0012120)2.80977325
26Infertility (HP:0000789)2.79720848
27Secondary amenorrhea (HP:0000869)2.79715041
28Increased CSF lactate (HP:0002490)2.75093854
29Ketosis (HP:0001946)2.71145556
30Abnormal spermatogenesis (HP:0008669)2.70148032
31Abnormality of renal resorption (HP:0011038)2.69895599
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69741497
33Abnormality of alanine metabolism (HP:0010916)2.69741497
34Hyperalaninemia (HP:0003348)2.69741497
35Bronchitis (HP:0012387)2.69582251
36Hepatic necrosis (HP:0002605)2.67388000
37Aplastic anemia (HP:0001915)2.65965786
38Microvesicular hepatic steatosis (HP:0001414)2.63446804
39Acute encephalopathy (HP:0006846)2.62695357
40Adrenal hypoplasia (HP:0000835)2.62564428
41Lipid accumulation in hepatocytes (HP:0006561)2.61707627
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56331543
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56331543
44Premature ovarian failure (HP:0008209)2.54910823
45Progressive macrocephaly (HP:0004481)2.53541402
46True hermaphroditism (HP:0010459)2.51928604
47Reticulocytopenia (HP:0001896)2.50594825
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50496278
49Exertional dyspnea (HP:0002875)2.48583759
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43505408
51Dicarboxylic aciduria (HP:0003215)2.43505408
52Abnormal number of erythroid precursors (HP:0012131)2.37999417
53Nasal polyposis (HP:0100582)2.37811772
54Nephronophthisis (HP:0000090)2.35744297
55Cerebral edema (HP:0002181)2.35408582
56Delusions (HP:0000746)2.34593485
57Lethargy (HP:0001254)2.34210970
58Type 2 muscle fiber atrophy (HP:0003554)2.33292028
59Flat capital femoral epiphysis (HP:0003370)2.31382397
60Increased serum lactate (HP:0002151)2.30857926
61Respiratory failure (HP:0002878)2.29594795
62Abnormality of cells of the erythroid lineage (HP:0012130)2.26384506
63Progressive microcephaly (HP:0000253)2.24344195
64Hypothermia (HP:0002045)2.24228805
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23141233
66Abnormal protein N-linked glycosylation (HP:0012347)2.23141233
67Abnormal protein glycosylation (HP:0012346)2.23141233
68Abnormal glycosylation (HP:0012345)2.23141233
69Cerebral hypomyelination (HP:0006808)2.22691997
70CNS demyelination (HP:0007305)2.22122501
71Pancreatic fibrosis (HP:0100732)2.20463266
72Tubulointerstitial nephritis (HP:0001970)2.18060305
73Exercise intolerance (HP:0003546)2.15927059
74Cleft eyelid (HP:0000625)2.14826390
75Chromsome breakage (HP:0040012)2.13787490
76Irregular epiphyses (HP:0010582)2.13128566
77Abnormality of lateral ventricle (HP:0030047)2.12142032
78Recurrent sinusitis (HP:0011108)2.12006708
79Increased muscle lipid content (HP:0009058)2.11482912
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09154516
81Pancreatic cysts (HP:0001737)2.08741057
82Muscle fiber atrophy (HP:0100295)2.05872984
83Optic disc pallor (HP:0000543)2.05522327
84Hypoglycemic coma (HP:0001325)2.04435271
85Pancytopenia (HP:0001876)2.04252726
86Abnormality of the parathyroid morphology (HP:0011766)2.04040692
87Bile duct proliferation (HP:0001408)2.02755872
88Abnormal biliary tract physiology (HP:0012439)2.02755872
89Reduced antithrombin III activity (HP:0001976)2.00725066
90Recurrent bronchitis (HP:0002837)1.98921991
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.98073691
92Aplasia/hypoplasia of the uterus (HP:0008684)1.97796124
93Molar tooth sign on MRI (HP:0002419)1.97435889
94Abnormality of midbrain morphology (HP:0002418)1.97435889
95Hyperinsulinemic hypoglycemia (HP:0000825)1.96513500
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95658866
97Azoospermia (HP:0000027)1.94670121
98Congenital primary aphakia (HP:0007707)1.93642164
99Lactic acidosis (HP:0003128)1.92812653
10011 pairs of ribs (HP:0000878)1.92436778
101Renal cortical cysts (HP:0000803)1.91703759
102Progressive inability to walk (HP:0002505)1.90309856
103Insulin-resistant diabetes mellitus (HP:0000831)1.89240175
104Abnormal rod and cone electroretinograms (HP:0008323)1.88502917
105Nephrogenic diabetes insipidus (HP:0009806)1.87872385
106Redundant skin (HP:0001582)1.86443650
107Attenuation of retinal blood vessels (HP:0007843)1.85776009
108Respiratory difficulties (HP:0002880)1.85753080
109Abnormality of the nasal mucosa (HP:0000433)1.85424652
110Poor speech (HP:0002465)1.85110810
111Abnormality of urine glucose concentration (HP:0011016)1.83446205
112Glycosuria (HP:0003076)1.83446205
113Abnormality of secondary sexual hair (HP:0009888)1.82881651
114Abnormality of the axillary hair (HP:0100134)1.82881651
115Sclerocornea (HP:0000647)1.82266665
116Broad distal phalanx of finger (HP:0009836)1.82170665
117Severe combined immunodeficiency (HP:0004430)1.81659176
118Gonadotropin excess (HP:0000837)1.80762945
119Abnormality of the renal medulla (HP:0100957)1.80503683
120Increased IgM level (HP:0003496)1.80206340
121Gait imbalance (HP:0002141)1.80190441
122Abnormality of glycine metabolism (HP:0010895)1.79958180
123Abnormality of serine family amino acid metabolism (HP:0010894)1.79958180
124Abnormality of chromosome stability (HP:0003220)1.79508436
125Prolonged neonatal jaundice (HP:0006579)1.78854451
126Vacuolated lymphocytes (HP:0001922)1.78645247
127Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.78522920
128Dry hair (HP:0011359)1.77951561
129Facial cleft (HP:0002006)1.76573411
130Generalized aminoaciduria (HP:0002909)1.76387349
131Abnormality of the renal collecting system (HP:0004742)1.76012726
132Increased intramyocellular lipid droplets (HP:0012240)1.75714684
133Disproportionate short-trunk short stature (HP:0003521)1.75388396
134Oculomotor apraxia (HP:0000657)1.75136527
135Double outlet right ventricle (HP:0001719)1.73537640
136Congenital malformation of the right heart (HP:0011723)1.73537640
137Supernumerary spleens (HP:0009799)1.72447537
138Hyperglycinuria (HP:0003108)1.71276063
139Agitation (HP:0000713)1.70789957
140Congenital sensorineural hearing impairment (HP:0008527)1.70528781
141Rough bone trabeculation (HP:0100670)1.70394927
142Abnormality of the vitamin B12 metabolism (HP:0004341)1.70296734
143Abnormality of the renal cortex (HP:0011035)1.69874016
144Metabolic acidosis (HP:0001942)1.69637980
145Constricted visual fields (HP:0001133)1.68515205
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.68139886
147Congenital, generalized hypertrichosis (HP:0004540)1.67072133
148Abnormality of the preputium (HP:0100587)1.66808917
149Abnormality of the metopic suture (HP:0005556)1.66382437
150Hypergonadotropic hypogonadism (HP:0000815)1.66307203
151Aplasia/Hypoplasia of the lens (HP:0008063)1.65536271
152Macrocytic anemia (HP:0001972)1.65022479
153Pallor (HP:0000980)1.64680359
154Duplicated collecting system (HP:0000081)1.64674273
155Decreased central vision (HP:0007663)1.64093997
156Patchy hypopigmentation of hair (HP:0011365)1.62503650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.85314999
2STK163.85227099
3FRK3.30686127
4SCYL23.19286663
5TAF13.06723623
6TESK12.73273050
7IRAK32.71864358
8CSNK1G32.62176527
9PLK42.55601689
10PDK42.34042128
11PDK32.34042128
12CSNK1G22.27190125
13TAOK32.22618873
14CSNK1G12.11940284
15EIF2AK12.09542057
16PDK22.03033342
17ZAK2.01675945
18IRAK41.98170776
19PIM21.91738437
20BUB11.91538423
21TXK1.91147068
22TLK11.83810612
23MAP4K21.82064822
24NME21.76186430
25IRAK11.73557816
26CSNK1A1L1.73013938
27MAPK151.70557633
28TNIK1.66163453
29NEK11.54897808
30CCNB11.52746187
31WEE11.50963231
32NME11.47041765
33VRK11.43234955
34DYRK31.42534332
35CASK1.40404236
36BLK1.37760539
37PBK1.36760063
38BMPR1B1.34144357
39MKNK21.29560447
40MAP2K71.27784586
41IRAK21.27523423
42PRKD31.24431238
43TEC1.24342312
44MUSK1.23717325
45BMPR21.23643418
46SRPK11.23115113
47ADRBK21.21465472
48BRSK21.21188501
49EIF2AK31.21181376
50MST41.11602045
51BRAF1.07371364
52CDK191.07168150
53YES11.06961625
54PASK1.04367093
55MAP3K141.00925311
56ACVR1B1.00405864
57INSRR0.98289675
58MAP3K40.95887364
59BCKDK0.94983690
60MKNK10.90040865
61STK40.89867599
62STK380.88854286
63STK390.88406118
64MAP2K60.85248635
65TRIM280.84509085
66ZAP700.83071132
67GRK70.81096014
68WNK40.79083556
69NLK0.78233988
70AKT30.77890594
71NEK60.77544761
72DYRK20.77538505
73PAK30.75801317
74TIE10.74651772
75RPS6KA40.72410791
76LIMK10.72272158
77MAP4K10.71854415
78GRK10.71825873
79GRK50.71541135
80BTK0.70934116
81DAPK10.70841268
82WNK30.70271202
83IKBKE0.69282542
84IKBKB0.67451334
85KIT0.67072864
86PLK30.66478761
87ARAF0.63929644
88KDR0.63909869
89EIF2AK20.61318401
90MYLK0.61291871
91ATR0.60738494
92CSNK2A10.58689653
93PINK10.58624822
94PLK10.57883228
95CDK80.57601944
96LYN0.55761287
97AURKA0.55463109
98BRSK10.54654272
99SMG10.53965568
100STK38L0.53901939
101TNK20.52605267
102ERBB30.52229202
103CDK30.52001636
104CHEK20.51769003
105CSNK1A10.49915133
106CLK10.49805422
107RPS6KA50.48788157
108SIK30.48421717
109MAPKAPK30.47781453
110NUAK10.46883156
111CDK70.46774877
112ABL20.46663156
113MAP3K120.46444498
114PIK3CG0.45726215
115CAMKK20.45685428
116PRKG20.45681159
117RAF10.45625101
118MAPKAPK50.45174091
119BCR0.43628724
120PIM10.42283227
121ICK0.40258440
122TTK0.40196009
123CSNK1D0.40060027
124MAPK110.39220369
125DYRK1B0.38074822
126STK240.37608964
127CSNK2A20.35945159
128PRKCI0.35758227
129TESK20.35378177
130LCK0.35145440
131MAP2K20.33174149
132MAP3K30.33165156
133CAMK1D0.32513884
134MAP3K110.30456285
135PRKCG0.27819362
136MAP2K40.26958549
137PRKCQ0.26596589
138ATM0.25400646

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.87218431
2Ribosome_Homo sapiens_hsa030103.55742302
3Proteasome_Homo sapiens_hsa030503.43171261
4RNA polymerase_Homo sapiens_hsa030203.28194391
5Oxidative phosphorylation_Homo sapiens_hsa001902.93678601
6DNA replication_Homo sapiens_hsa030302.72174053
7Pyrimidine metabolism_Homo sapiens_hsa002402.51150647
8Homologous recombination_Homo sapiens_hsa034402.49051815
9Parkinsons disease_Homo sapiens_hsa050122.43927788
10Mismatch repair_Homo sapiens_hsa034302.38601019
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26334475
12Basal transcription factors_Homo sapiens_hsa030222.24679118
13Huntingtons disease_Homo sapiens_hsa050162.15009376
14Fanconi anemia pathway_Homo sapiens_hsa034602.02830686
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.79257521
16Nucleotide excision repair_Homo sapiens_hsa034201.78316822
17Base excision repair_Homo sapiens_hsa034101.77934747
18Non-homologous end-joining_Homo sapiens_hsa034501.77462604
19Alzheimers disease_Homo sapiens_hsa050101.71236013
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68490766
21Purine metabolism_Homo sapiens_hsa002301.68332295
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59192017
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57591386
24Spliceosome_Homo sapiens_hsa030401.50842234
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.49109208
26Other glycan degradation_Homo sapiens_hsa005111.46913698
27Butanoate metabolism_Homo sapiens_hsa006501.44844971
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43524294
29Arachidonic acid metabolism_Homo sapiens_hsa005901.40659812
30RNA degradation_Homo sapiens_hsa030181.39033482
31Linoleic acid metabolism_Homo sapiens_hsa005911.33772413
32Propanoate metabolism_Homo sapiens_hsa006401.31645996
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.29131252
34Folate biosynthesis_Homo sapiens_hsa007901.21084167
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13769801
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10539596
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08187224
38Sulfur metabolism_Homo sapiens_hsa009201.06408545
39Glutathione metabolism_Homo sapiens_hsa004801.06311599
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02839467
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00460074
42Fatty acid metabolism_Homo sapiens_hsa012121.00295877
43Primary immunodeficiency_Homo sapiens_hsa053400.99047084
44RNA transport_Homo sapiens_hsa030130.97775264
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92593134
46Sphingolipid metabolism_Homo sapiens_hsa006000.87059589
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87023136
48Caffeine metabolism_Homo sapiens_hsa002320.86783580
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.86283659
50Nitrogen metabolism_Homo sapiens_hsa009100.85310944
51Antigen processing and presentation_Homo sapiens_hsa046120.84886052
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84532686
53Metabolic pathways_Homo sapiens_hsa011000.83567714
54Allograft rejection_Homo sapiens_hsa053300.82513198
55Vitamin B6 metabolism_Homo sapiens_hsa007500.81816533
56Tryptophan metabolism_Homo sapiens_hsa003800.81733934
57Chemical carcinogenesis_Homo sapiens_hsa052040.81029825
58Ether lipid metabolism_Homo sapiens_hsa005650.77103964
59One carbon pool by folate_Homo sapiens_hsa006700.76013672
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.75299907
61Fatty acid elongation_Homo sapiens_hsa000620.74653245
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71341138
63Cardiac muscle contraction_Homo sapiens_hsa042600.69945453
64Autoimmune thyroid disease_Homo sapiens_hsa053200.69628105
65Peroxisome_Homo sapiens_hsa041460.69075004
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68178427
67Herpes simplex infection_Homo sapiens_hsa051680.67283339
68Graft-versus-host disease_Homo sapiens_hsa053320.67227611
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66836978
70Epstein-Barr virus infection_Homo sapiens_hsa051690.66167281
71N-Glycan biosynthesis_Homo sapiens_hsa005100.64336750
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.64111807
73Legionellosis_Homo sapiens_hsa051340.63712354
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63016959
75Pyruvate metabolism_Homo sapiens_hsa006200.62826097
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.62585027
77Measles_Homo sapiens_hsa051620.62477777
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.61491150
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59632808
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59295914
81Cell cycle_Homo sapiens_hsa041100.59097027
82Pentose phosphate pathway_Homo sapiens_hsa000300.58913235
83Circadian rhythm_Homo sapiens_hsa047100.58097065
84Retinol metabolism_Homo sapiens_hsa008300.57670202
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57311770
86Hematopoietic cell lineage_Homo sapiens_hsa046400.56358901
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55059658
88Asthma_Homo sapiens_hsa053100.54891824
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54842975
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54129263
91Rheumatoid arthritis_Homo sapiens_hsa053230.53374290
92Collecting duct acid secretion_Homo sapiens_hsa049660.52570526
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50999510
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.50819251
95Steroid biosynthesis_Homo sapiens_hsa001000.49207394
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.48998281
97Sulfur relay system_Homo sapiens_hsa041220.48153973
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47652606
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47027872
100Fructose and mannose metabolism_Homo sapiens_hsa000510.46251887
101Regulation of autophagy_Homo sapiens_hsa041400.45966588
102Vibrio cholerae infection_Homo sapiens_hsa051100.45916561
103Systemic lupus erythematosus_Homo sapiens_hsa053220.44006716
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43536224
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.42848342
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42250873
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40641106
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40351332
109p53 signaling pathway_Homo sapiens_hsa041150.39821621
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38916316
111Selenocompound metabolism_Homo sapiens_hsa004500.36026478
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35647218
113beta-Alanine metabolism_Homo sapiens_hsa004100.34365781
114Vitamin digestion and absorption_Homo sapiens_hsa049770.33656590
115Phototransduction_Homo sapiens_hsa047440.33449317
116Galactose metabolism_Homo sapiens_hsa000520.33135267
117Lysosome_Homo sapiens_hsa041420.32234436
118Type I diabetes mellitus_Homo sapiens_hsa049400.31511496
119mRNA surveillance pathway_Homo sapiens_hsa030150.30795695
120Histidine metabolism_Homo sapiens_hsa003400.27989371
121Fatty acid degradation_Homo sapiens_hsa000710.27343605
122Shigellosis_Homo sapiens_hsa051310.26003978
123Fatty acid biosynthesis_Homo sapiens_hsa000610.25578732
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23040701
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18456400
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18419402
127Starch and sucrose metabolism_Homo sapiens_hsa005000.18256024
128Mineral absorption_Homo sapiens_hsa049780.15346824

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