

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 6.15896541 |
| 2 | ribosome assembly (GO:0042255) | 6.02250244 |
| 3 | ribosomal large subunit biogenesis (GO:0042273) | 4.71422089 |
| 4 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.48191378 |
| 5 | cullin deneddylation (GO:0010388) | 4.48150811 |
| 6 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.47371448 |
| 7 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.41519144 |
| 8 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.26845860 |
| 9 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.24765393 |
| 10 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.15904398 |
| 11 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.15904398 |
| 12 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.15904398 |
| 13 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.14694724 |
| 14 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.14694724 |
| 15 | negative regulation of ligase activity (GO:0051352) | 4.13145245 |
| 16 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.13145245 |
| 17 | protein deneddylation (GO:0000338) | 4.12540182 |
| 18 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.05210191 |
| 19 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.03619570 |
| 20 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 4.01327788 |
| 21 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 4.01327788 |
| 22 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.99708017 |
| 23 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.92819885 |
| 24 | positive regulation of ligase activity (GO:0051351) | 3.84220637 |
| 25 | organelle disassembly (GO:1903008) | 3.77207714 |
| 26 | DNA deamination (GO:0045006) | 3.68666013 |
| 27 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.67888376 |
| 28 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.64149431 |
| 29 | 7-methylguanosine mRNA capping (GO:0006370) | 3.60685083 |
| 30 | ATP synthesis coupled proton transport (GO:0015986) | 3.58036293 |
| 31 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.58036293 |
| 32 | protein complex biogenesis (GO:0070271) | 3.56500633 |
| 33 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.54718941 |
| 34 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.51917883 |
| 35 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.51646212 |
| 36 | 7-methylguanosine RNA capping (GO:0009452) | 3.50824486 |
| 37 | RNA capping (GO:0036260) | 3.50824486 |
| 38 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.48648112 |
| 39 | ribonucleoprotein complex disassembly (GO:0032988) | 3.47983811 |
| 40 | regulation of mitochondrial translation (GO:0070129) | 3.46540010 |
| 41 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.45999075 |
| 42 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.43549554 |
| 43 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.43549554 |
| 44 | peptidyl-histidine modification (GO:0018202) | 3.41698456 |
| 45 | inner mitochondrial membrane organization (GO:0007007) | 3.40849963 |
| 46 | regulation of ligase activity (GO:0051340) | 3.35337328 |
| 47 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.31622582 |
| 48 | termination of RNA polymerase III transcription (GO:0006386) | 3.31239237 |
| 49 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.31239237 |
| 50 | protein K11-linked ubiquitination (GO:0070979) | 3.30981869 |
| 51 | spliceosomal snRNP assembly (GO:0000387) | 3.30970796 |
| 52 | amino acid salvage (GO:0043102) | 3.28301500 |
| 53 | L-methionine salvage (GO:0071267) | 3.28301500 |
| 54 | L-methionine biosynthetic process (GO:0071265) | 3.28301500 |
| 55 | regulation of mitotic spindle organization (GO:0060236) | 3.27183411 |
| 56 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.25632910 |
| 57 | maturation of 5.8S rRNA (GO:0000460) | 3.25045552 |
| 58 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.23365266 |
| 59 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.23365266 |
| 60 | NADH dehydrogenase complex assembly (GO:0010257) | 3.23365266 |
| 61 | rRNA modification (GO:0000154) | 3.20568358 |
| 62 | negative regulation of protein ubiquitination (GO:0031397) | 3.18405615 |
| 63 | positive regulation of cell cycle arrest (GO:0071158) | 3.17291767 |
| 64 | termination of RNA polymerase I transcription (GO:0006363) | 3.17004880 |
| 65 | protein-cofactor linkage (GO:0018065) | 3.16719482 |
| 66 | respiratory electron transport chain (GO:0022904) | 3.12982282 |
| 67 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.12372074 |
| 68 | mitochondrial RNA metabolic process (GO:0000959) | 3.12330889 |
| 69 | electron transport chain (GO:0022900) | 3.11682452 |
| 70 | mannosylation (GO:0097502) | 3.08082324 |
| 71 | respiratory chain complex IV assembly (GO:0008535) | 3.07001754 |
| 72 | tRNA processing (GO:0008033) | 3.00161068 |
| 73 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.97994827 |
| 74 | regulation of spindle organization (GO:0090224) | 2.94200322 |
| 75 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.93971433 |
| 76 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.92969382 |
| 77 | rRNA processing (GO:0006364) | 2.90491948 |
| 78 | transcription from RNA polymerase I promoter (GO:0006360) | 2.84652707 |
| 79 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.84269426 |
| 80 | pseudouridine synthesis (GO:0001522) | 2.83245344 |
| 81 | rRNA metabolic process (GO:0016072) | 2.83010293 |
| 82 | DNA double-strand break processing (GO:0000729) | 2.80502905 |
| 83 | protein targeting to mitochondrion (GO:0006626) | 2.80129077 |
| 84 | regulation of cell cycle arrest (GO:0071156) | 2.79228340 |
| 85 | negative regulation of cell cycle G1/S phase transition (GO:1902807) | 2.79131215 |
| 86 | negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) | 2.79131215 |
| 87 | positive regulation of protein ubiquitination (GO:0031398) | 2.77600965 |
| 88 | cytochrome complex assembly (GO:0017004) | 2.75453382 |
| 89 | tRNA metabolic process (GO:0006399) | 2.75191252 |
| 90 | rRNA methylation (GO:0031167) | 2.74979257 |
| 91 | protein K6-linked ubiquitination (GO:0085020) | 2.74848309 |
| 92 | intracellular protein transmembrane import (GO:0044743) | 2.73237898 |
| 93 | platelet dense granule organization (GO:0060155) | 2.72941668 |
| 94 | protein localization to mitochondrion (GO:0070585) | 2.72455066 |
| 95 | ubiquinone biosynthetic process (GO:0006744) | 2.72115815 |
| 96 | metallo-sulfur cluster assembly (GO:0031163) | 2.70595886 |
| 97 | iron-sulfur cluster assembly (GO:0016226) | 2.70595886 |
| 98 | regulation of cellular amine metabolic process (GO:0033238) | 2.70407640 |
| 99 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.69902626 |
| 100 | methionine biosynthetic process (GO:0009086) | 2.69572495 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 5.10002829 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.94033163 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.17137546 |
| 4 | ELK1_19687146_ChIP-ChIP_HELA_Human | 3.60094764 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.47672204 |
| 6 | * VDR_23849224_ChIP-Seq_CD4+_Human | 3.33762897 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.14614668 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.14105797 |
| 9 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.13656054 |
| 10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.04898672 |
| 11 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.91543073 |
| 12 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.70074676 |
| 13 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.58099703 |
| 14 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.52313962 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.50483170 |
| 16 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.50205886 |
| 17 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.49918365 |
| 18 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.43523281 |
| 19 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.38411049 |
| 20 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.34379933 |
| 21 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.21247637 |
| 22 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.18948000 |
| 23 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.18451819 |
| 24 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.10319376 |
| 25 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.89183660 |
| 26 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.85729382 |
| 27 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.83679549 |
| 28 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.83392799 |
| 29 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.79556899 |
| 30 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.79086717 |
| 31 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.78501212 |
| 32 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.77213927 |
| 33 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.75188806 |
| 34 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.73709473 |
| 35 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.61294911 |
| 36 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.60125696 |
| 37 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.59207523 |
| 38 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.57793723 |
| 39 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.50106436 |
| 40 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.49729456 |
| 41 | VDR_22108803_ChIP-Seq_LS180_Human | 1.46612290 |
| 42 | EWS_26573619_Chip-Seq_HEK293_Human | 1.46075315 |
| 43 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.44756024 |
| 44 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.36594862 |
| 45 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.35943394 |
| 46 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.35883697 |
| 47 | FUS_26573619_Chip-Seq_HEK293_Human | 1.35406945 |
| 48 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.34191682 |
| 49 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.33605960 |
| 50 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.30823739 |
| 51 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.29738439 |
| 52 | * ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.28904466 |
| 53 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.28185902 |
| 54 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.27222728 |
| 55 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.26406522 |
| 56 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.23353827 |
| 57 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.23005985 |
| 58 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.22742462 |
| 59 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.19590450 |
| 60 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.18520192 |
| 61 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.17981864 |
| 62 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.17914380 |
| 63 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.16501848 |
| 64 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.11166563 |
| 65 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.10522125 |
| 66 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.09392035 |
| 67 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.07697614 |
| 68 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.04665820 |
| 69 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.02124464 |
| 70 | GATA3_26560356_Chip-Seq_TH2_Human | 0.99907431 |
| 71 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.99318925 |
| 72 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.98038417 |
| 73 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.95950054 |
| 74 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.94124350 |
| 75 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.93694536 |
| 76 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.92864662 |
| 77 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.92573296 |
| 78 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.92375875 |
| 79 | P300_19829295_ChIP-Seq_ESCs_Human | 0.90418369 |
| 80 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.89822368 |
| 81 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.88800463 |
| 82 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.88312613 |
| 83 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.88275261 |
| 84 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87480778 |
| 85 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.86162180 |
| 86 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.85561734 |
| 87 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.85267612 |
| 88 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84552543 |
| 89 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84313978 |
| 90 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.83545457 |
| 91 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.82938489 |
| 92 | AR_20517297_ChIP-Seq_VCAP_Human | 0.82892181 |
| 93 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.82210243 |
| 94 | BRD4_25478319_ChIP-Seq_HGPS_Human | 0.81970567 |
| 95 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.80840247 |
| 96 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.78097554 |
| 97 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.77935446 |
| 98 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.77641554 |
| 99 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.77638380 |
| 100 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.77376174 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003950_abnormal_plasma_membrane | 4.15526952 |
| 2 | MP0008058_abnormal_DNA_repair | 3.60059485 |
| 3 | MP0003786_premature_aging | 3.17236460 |
| 4 | MP0002102_abnormal_ear_morphology | 2.98611189 |
| 5 | MP0006072_abnormal_retinal_apoptosis | 2.92746161 |
| 6 | MP0000372_irregular_coat_pigmentation | 2.87963006 |
| 7 | MP0003806_abnormal_nucleotide_metabolis | 2.42470346 |
| 8 | MP0003693_abnormal_embryo_hatching | 2.39238807 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.32452302 |
| 10 | MP0003011_delayed_dark_adaptation | 2.25384934 |
| 11 | MP0003186_abnormal_redox_activity | 2.13471661 |
| 12 | MP0010094_abnormal_chromosome_stability | 2.09960578 |
| 13 | MP0000569_abnormal_digit_pigmentation | 2.08742470 |
| 14 | MP0000013_abnormal_adipose_tissue | 2.06531709 |
| 15 | MP0008057_abnormal_DNA_replication | 1.93604715 |
| 16 | MP0008995_early_reproductive_senescence | 1.89809631 |
| 17 | MP0009697_abnormal_copulation | 1.88889708 |
| 18 | MP0008877_abnormal_DNA_methylation | 1.86263061 |
| 19 | MP0001529_abnormal_vocalization | 1.82690390 |
| 20 | MP0003077_abnormal_cell_cycle | 1.79984070 |
| 21 | MP0006036_abnormal_mitochondrial_physio | 1.75183665 |
| 22 | MP0005075_abnormal_melanosome_morpholog | 1.70324095 |
| 23 | MP0005084_abnormal_gallbladder_morpholo | 1.64888415 |
| 24 | MP0006035_abnormal_mitochondrial_morpho | 1.56956832 |
| 25 | MP0001542_abnormal_bone_strength | 1.51497557 |
| 26 | MP0009780_abnormal_chondrocyte_physiolo | 1.48858170 |
| 27 | MP0005253_abnormal_eye_physiology | 1.43629993 |
| 28 | MP0002736_abnormal_nociception_after | 1.43344999 |
| 29 | MP0003763_abnormal_thymus_physiology | 1.40847756 |
| 30 | MP0010386_abnormal_urinary_bladder | 1.38127985 |
| 31 | MP0004957_abnormal_blastocyst_morpholog | 1.37157877 |
| 32 | MP0002282_abnormal_trachea_morphology | 1.35089284 |
| 33 | MP0000749_muscle_degeneration | 1.32746401 |
| 34 | MP0001986_abnormal_taste_sensitivity | 1.32736897 |
| 35 | MP0008932_abnormal_embryonic_tissue | 1.31025309 |
| 36 | MP0001243_abnormal_dermal_layer | 1.31018815 |
| 37 | MP0005360_urolithiasis | 1.28047379 |
| 38 | MP0003656_abnormal_erythrocyte_physiolo | 1.27048617 |
| 39 | MP0004147_increased_porphyrin_level | 1.26385474 |
| 40 | MP0005187_abnormal_penis_morphology | 1.25375105 |
| 41 | MP0000358_abnormal_cell_content/ | 1.25235620 |
| 42 | MP0005551_abnormal_eye_electrophysiolog | 1.24235742 |
| 43 | MP0002095_abnormal_skin_pigmentation | 1.22717670 |
| 44 | MP0001502_abnormal_circadian_rhythm | 1.20862280 |
| 45 | MP0001929_abnormal_gametogenesis | 1.17979196 |
| 46 | MP0003718_maternal_effect | 1.16578557 |
| 47 | MP0001853_heart_inflammation | 1.12352993 |
| 48 | MP0001764_abnormal_homeostasis | 1.12329260 |
| 49 | MP0005266_abnormal_metabolism | 1.12247574 |
| 50 | MP0004215_abnormal_myocardial_fiber | 1.11281785 |
| 51 | MP0003111_abnormal_nucleus_morphology | 1.10732250 |
| 52 | MP0001879_abnormal_lymphatic_vessel | 1.10416376 |
| 53 | MP0003252_abnormal_bile_duct | 1.10267231 |
| 54 | MP0000647_abnormal_sebaceous_gland | 1.06812584 |
| 55 | MP0004142_abnormal_muscle_tone | 1.06648490 |
| 56 | MP0005410_abnormal_fertilization | 1.06123578 |
| 57 | MP0002638_abnormal_pupillary_reflex | 1.02991227 |
| 58 | MP0005389_reproductive_system_phenotype | 1.00649915 |
| 59 | MP0006054_spinal_hemorrhage | 0.99980629 |
| 60 | MP0002210_abnormal_sex_determination | 0.97643810 |
| 61 | MP0006276_abnormal_autonomic_nervous | 0.97613208 |
| 62 | MP0003959_abnormal_lean_body | 0.96468324 |
| 63 | MP0002234_abnormal_pharynx_morphology | 0.92439329 |
| 64 | MP0008438_abnormal_cutaneous_collagen | 0.91324899 |
| 65 | MP0000653_abnormal_sex_gland | 0.90730675 |
| 66 | MP0005171_absent_coat_pigmentation | 0.89870781 |
| 67 | MP0000015_abnormal_ear_pigmentation | 0.89248671 |
| 68 | MP0002295_abnormal_pulmonary_circulatio | 0.88816637 |
| 69 | MP0001984_abnormal_olfaction | 0.84120012 |
| 70 | MP0009384_cardiac_valve_regurgitation | 0.83800156 |
| 71 | MP0000538_abnormal_urinary_bladder | 0.82415153 |
| 72 | MP0002938_white_spotting | 0.82068168 |
| 73 | MP0001919_abnormal_reproductive_system | 0.81041049 |
| 74 | MP0000427_abnormal_hair_cycle | 0.80610144 |
| 75 | MP0005646_abnormal_pituitary_gland | 0.79523461 |
| 76 | MP0001119_abnormal_female_reproductive | 0.79426422 |
| 77 | MP0002332_abnormal_exercise_endurance | 0.77068639 |
| 78 | MP0005623_abnormal_meninges_morphology | 0.75604050 |
| 79 | MP0001905_abnormal_dopamine_level | 0.75125203 |
| 80 | MP0005645_abnormal_hypothalamus_physiol | 0.74823508 |
| 81 | MP0002163_abnormal_gland_morphology | 0.74289861 |
| 82 | MP0000613_abnormal_salivary_gland | 0.73669900 |
| 83 | MP0005379_endocrine/exocrine_gland_phen | 0.73128828 |
| 84 | MP0008961_abnormal_basal_metabolism | 0.71900576 |
| 85 | MP0005376_homeostasis/metabolism_phenot | 0.71831122 |
| 86 | MP0003279_aneurysm | 0.71775764 |
| 87 | MP0001145_abnormal_male_reproductive | 0.70666017 |
| 88 | MP0008872_abnormal_physiological_respon | 0.70154969 |
| 89 | MP0002837_dystrophic_cardiac_calcinosis | 0.69968133 |
| 90 | MP0003137_abnormal_impulse_conducting | 0.69355143 |
| 91 | MP0010368_abnormal_lymphatic_system | 0.68744807 |
| 92 | MP0000689_abnormal_spleen_morphology | 0.66455437 |
| 93 | MP0005164_abnormal_response_to | 0.66142154 |
| 94 | MP0000383_abnormal_hair_follicle | 0.65599264 |
| 95 | MP0002751_abnormal_autonomic_nervous | 0.64876184 |
| 96 | MP0000350_abnormal_cell_proliferation | 0.64807232 |
| 97 | MP0001727_abnormal_embryo_implantation | 0.64766793 |
| 98 | MP0001968_abnormal_touch/_nociception | 0.64015549 |
| 99 | MP0004883_abnormal_blood_vessel | 0.62785343 |
| 100 | MP0004134_abnormal_chest_morphology | 0.62280532 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.14627778 |
| 2 | Mitochondrial inheritance (HP:0001427) | 3.94248457 |
| 3 | Metaphyseal dysplasia (HP:0100255) | 3.87071295 |
| 4 | Hepatic necrosis (HP:0002605) | 3.85342273 |
| 5 | Increased CSF lactate (HP:0002490) | 3.84395125 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.78349473 |
| 7 | Hepatocellular necrosis (HP:0001404) | 3.71084969 |
| 8 | Acute encephalopathy (HP:0006846) | 3.62773336 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.62407728 |
| 10 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.47312754 |
| 11 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.47312754 |
| 12 | Neonatal respiratory distress (HP:0002643) | 3.38884113 |
| 13 | Increased hepatocellular lipid droplets (HP:0006565) | 3.37271470 |
| 14 | Congenital, generalized hypertrichosis (HP:0004540) | 3.25737065 |
| 15 | Renal cortical cysts (HP:0000803) | 3.19638548 |
| 16 | 3-Methylglutaconic aciduria (HP:0003535) | 3.13682570 |
| 17 | Type I transferrin isoform profile (HP:0003642) | 3.12507880 |
| 18 | Lipid accumulation in hepatocytes (HP:0006561) | 3.01161478 |
| 19 | Increased serum lactate (HP:0002151) | 2.98177631 |
| 20 | Dyschromatopsia (HP:0007641) | 2.91254375 |
| 21 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.88147124 |
| 22 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.88147124 |
| 23 | Abnormal protein glycosylation (HP:0012346) | 2.88147124 |
| 24 | Abnormal glycosylation (HP:0012345) | 2.88147124 |
| 25 | Fibular aplasia (HP:0002990) | 2.85904971 |
| 26 | Type 2 muscle fiber atrophy (HP:0003554) | 2.84556055 |
| 27 | Increased intramyocellular lipid droplets (HP:0012240) | 2.70851680 |
| 28 | Pancreatic cysts (HP:0001737) | 2.70644090 |
| 29 | Generalized aminoaciduria (HP:0002909) | 2.66982163 |
| 30 | Cerebral edema (HP:0002181) | 2.63732607 |
| 31 | Lactic acidosis (HP:0003128) | 2.59931163 |
| 32 | Short tibia (HP:0005736) | 2.48554756 |
| 33 | Abnormality of alanine metabolism (HP:0010916) | 2.48364320 |
| 34 | Hyperalaninemia (HP:0003348) | 2.48364320 |
| 35 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.48364320 |
| 36 | Muscle fiber atrophy (HP:0100295) | 2.46806623 |
| 37 | Oral leukoplakia (HP:0002745) | 2.40064356 |
| 38 | Large for gestational age (HP:0001520) | 2.39728447 |
| 39 | Pancytopenia (HP:0001876) | 2.37057772 |
| 40 | Renal Fanconi syndrome (HP:0001994) | 2.34136772 |
| 41 | Abnormality of midbrain morphology (HP:0002418) | 2.34059121 |
| 42 | Molar tooth sign on MRI (HP:0002419) | 2.34059121 |
| 43 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.33437846 |
| 44 | IgG deficiency (HP:0004315) | 2.30891204 |
| 45 | Abnormality of the renal cortex (HP:0011035) | 2.30245735 |
| 46 | Reduced antithrombin III activity (HP:0001976) | 2.26319534 |
| 47 | Optic disc pallor (HP:0000543) | 2.24812508 |
| 48 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.24588110 |
| 49 | Palpitations (HP:0001962) | 2.22192138 |
| 50 | Methylmalonic acidemia (HP:0002912) | 2.20004010 |
| 51 | Pancreatic fibrosis (HP:0100732) | 2.18976812 |
| 52 | Medial flaring of the eyebrow (HP:0010747) | 2.15284698 |
| 53 | Abnormality of the costochondral junction (HP:0000919) | 2.14485879 |
| 54 | Abnormality of the anterior horn cell (HP:0006802) | 2.14024213 |
| 55 | Degeneration of anterior horn cells (HP:0002398) | 2.14024213 |
| 56 | Concave nail (HP:0001598) | 2.11994534 |
| 57 | Hypoproteinemia (HP:0003075) | 2.09839916 |
| 58 | Increased muscle lipid content (HP:0009058) | 2.08709950 |
| 59 | Posterior subcapsular cataract (HP:0007787) | 2.08196945 |
| 60 | Sensory axonal neuropathy (HP:0003390) | 2.07948034 |
| 61 | Hypothermia (HP:0002045) | 2.06139723 |
| 62 | Severe combined immunodeficiency (HP:0004430) | 2.06032992 |
| 63 | Aplastic anemia (HP:0001915) | 2.05703200 |
| 64 | Abnormal number of erythroid precursors (HP:0012131) | 2.05678653 |
| 65 | Exertional dyspnea (HP:0002875) | 2.05656520 |
| 66 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.04969668 |
| 67 | Exercise intolerance (HP:0003546) | 2.03647244 |
| 68 | Respiratory failure (HP:0002878) | 2.02213385 |
| 69 | Delayed gross motor development (HP:0002194) | 2.00254595 |
| 70 | Abnormality of macular pigmentation (HP:0008002) | 1.99533079 |
| 71 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.99464385 |
| 72 | Abnormality of placental membranes (HP:0011409) | 1.98785522 |
| 73 | Amniotic constriction ring (HP:0009775) | 1.98785522 |
| 74 | Testicular atrophy (HP:0000029) | 1.97242605 |
| 75 | True hermaphroditism (HP:0010459) | 1.96886665 |
| 76 | Sparse eyelashes (HP:0000653) | 1.96326086 |
| 77 | Tongue fasciculations (HP:0001308) | 1.94160180 |
| 78 | Nemaline bodies (HP:0003798) | 1.93949098 |
| 79 | Abnormality of the pons (HP:0007361) | 1.92994141 |
| 80 | Type I diabetes mellitus (HP:0100651) | 1.88765052 |
| 81 | Steatorrhea (HP:0002570) | 1.86666787 |
| 82 | Nephronophthisis (HP:0000090) | 1.86626122 |
| 83 | CNS demyelination (HP:0007305) | 1.85228653 |
| 84 | Abnormal hemoglobin (HP:0011902) | 1.85021633 |
| 85 | Lethargy (HP:0001254) | 1.83393175 |
| 86 | Neutropenia (HP:0001875) | 1.83206735 |
| 87 | Facial diplegia (HP:0001349) | 1.82470057 |
| 88 | Delayed CNS myelination (HP:0002188) | 1.81352910 |
| 89 | Leukodystrophy (HP:0002415) | 1.79996756 |
| 90 | Methylmalonic aciduria (HP:0012120) | 1.79539009 |
| 91 | Hypoglycemic coma (HP:0001325) | 1.78463770 |
| 92 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.77199531 |
| 93 | Congenital primary aphakia (HP:0007707) | 1.75182922 |
| 94 | Poor suck (HP:0002033) | 1.75114560 |
| 95 | Median cleft lip (HP:0000161) | 1.75004593 |
| 96 | Cerebral hypomyelination (HP:0006808) | 1.74969554 |
| 97 | Dry hair (HP:0011359) | 1.74042504 |
| 98 | Macrocytic anemia (HP:0001972) | 1.72968734 |
| 99 | Constricted visual fields (HP:0001133) | 1.72179616 |
| 100 | Thyroiditis (HP:0100646) | 1.72074580 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EIF2AK3 | 3.85304346 |
| 2 | TAOK3 | 3.11627463 |
| 3 | EIF2AK1 | 2.94490678 |
| 4 | BUB1 | 2.91395422 |
| 5 | MAP3K12 | 2.85076843 |
| 6 | VRK2 | 2.71965888 |
| 7 | MAP4K2 | 2.67324056 |
| 8 | SRPK1 | 2.44209771 |
| 9 | MST4 | 2.39564308 |
| 10 | BMPR1B | 2.38911216 |
| 11 | TXK | 2.36265397 |
| 12 | ZAK | 2.28894307 |
| 13 | VRK1 | 2.23573534 |
| 14 | TSSK6 | 2.11016684 |
| 15 | CDK8 | 2.09153395 |
| 16 | TRIM28 | 2.00308565 |
| 17 | STK16 | 1.76947736 |
| 18 | ERBB3 | 1.76394051 |
| 19 | NUAK1 | 1.76310129 |
| 20 | LIMK1 | 1.61475650 |
| 21 | SIK3 | 1.58684389 |
| 22 | PLK3 | 1.48756041 |
| 23 | MUSK | 1.47456649 |
| 24 | MYLK | 1.46249327 |
| 25 | GRK7 | 1.43503424 |
| 26 | BMPR2 | 1.41350518 |
| 27 | BRSK2 | 1.33512771 |
| 28 | PBK | 1.33491322 |
| 29 | SCYL2 | 1.30564520 |
| 30 | PDK2 | 1.28547901 |
| 31 | NEK1 | 1.28131626 |
| 32 | CCNB1 | 1.26520265 |
| 33 | PLK2 | 1.20247632 |
| 34 | MAPKAPK3 | 1.19482392 |
| 35 | WEE1 | 1.16325577 |
| 36 | EIF2AK2 | 1.12757345 |
| 37 | PNCK | 1.07862972 |
| 38 | CDC7 | 1.05200024 |
| 39 | ADRBK2 | 0.99469117 |
| 40 | INSRR | 0.98786878 |
| 41 | CSNK1G3 | 0.98764883 |
| 42 | FRK | 0.92823637 |
| 43 | TEC | 0.91702749 |
| 44 | CSNK1A1L | 0.91503677 |
| 45 | WNK3 | 0.91294333 |
| 46 | PASK | 0.90955464 |
| 47 | GRK1 | 0.87660539 |
| 48 | BCR | 0.87540328 |
| 49 | CSNK1G1 | 0.83746605 |
| 50 | STK39 | 0.83133465 |
| 51 | PIK3CG | 0.79739725 |
| 52 | ABL2 | 0.77812842 |
| 53 | PLK1 | 0.77363563 |
| 54 | TLK1 | 0.70695565 |
| 55 | PLK4 | 0.67632483 |
| 56 | CSNK1G2 | 0.66963305 |
| 57 | CLK1 | 0.65690866 |
| 58 | RPS6KA4 | 0.65265967 |
| 59 | IKBKB | 0.64414002 |
| 60 | PIM2 | 0.64143598 |
| 61 | TGFBR1 | 0.63998399 |
| 62 | BRSK1 | 0.60669859 |
| 63 | ILK | 0.60441922 |
| 64 | RPS6KA5 | 0.59857260 |
| 65 | TESK1 | 0.58167862 |
| 66 | ADRBK1 | 0.57571401 |
| 67 | BCKDK | 0.57408274 |
| 68 | ERBB4 | 0.56113421 |
| 69 | STK38L | 0.55402105 |
| 70 | AURKB | 0.52874146 |
| 71 | MKNK2 | 0.52132088 |
| 72 | ACVR1B | 0.51101113 |
| 73 | NEK6 | 0.50816167 |
| 74 | TRPM7 | 0.49958616 |
| 75 | PRKCE | 0.49690212 |
| 76 | ATR | 0.49201717 |
| 77 | TAF1 | 0.49130560 |
| 78 | CSNK2A1 | 0.48009933 |
| 79 | NME2 | 0.47143929 |
| 80 | PIM1 | 0.45117960 |
| 81 | TTK | 0.44469610 |
| 82 | PRKCI | 0.44274642 |
| 83 | CDK9 | 0.43721521 |
| 84 | CAMKK2 | 0.43332629 |
| 85 | GRK5 | 0.42833828 |
| 86 | CHEK2 | 0.42733646 |
| 87 | ABL1 | 0.41003799 |
| 88 | NME1 | 0.40737667 |
| 89 | PAK2 | 0.39340113 |
| 90 | IRAK3 | 0.38266854 |
| 91 | CSNK2A2 | 0.38078741 |
| 92 | PINK1 | 0.37094587 |
| 93 | IGF1R | 0.36423187 |
| 94 | ITK | 0.35291457 |
| 95 | MAPK13 | 0.35267845 |
| 96 | ATM | 0.34994037 |
| 97 | FLT3 | 0.32745675 |
| 98 | IKBKE | 0.32468761 |
| 99 | STK10 | 0.31683340 |
| 100 | PAK3 | 0.31440887 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.37038033 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.70549743 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.52905358 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.29440223 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.21806468 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.69534158 |
| 7 | Basal transcription factors_Homo sapiens_hsa03022 | 2.68310826 |
| 8 | Ribosome_Homo sapiens_hsa03010 | 2.30371970 |
| 9 | Spliceosome_Homo sapiens_hsa03040 | 2.16534904 |
| 10 | RNA degradation_Homo sapiens_hsa03018 | 2.05313928 |
| 11 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.01636472 |
| 12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.98951643 |
| 13 | Mismatch repair_Homo sapiens_hsa03430 | 1.97439018 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.92910558 |
| 15 | RNA transport_Homo sapiens_hsa03013 | 1.86245235 |
| 16 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.86093342 |
| 17 | Huntingtons disease_Homo sapiens_hsa05016 | 1.82462662 |
| 18 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.77114720 |
| 19 | Homologous recombination_Homo sapiens_hsa03440 | 1.76252314 |
| 20 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.73134927 |
| 21 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.70717859 |
| 22 | Alzheimers disease_Homo sapiens_hsa05010 | 1.65552571 |
| 23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.64482828 |
| 24 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.63732864 |
| 25 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.62237972 |
| 26 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.56299697 |
| 27 | DNA replication_Homo sapiens_hsa03030 | 1.51868318 |
| 28 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.50754545 |
| 29 | Circadian rhythm_Homo sapiens_hsa04710 | 1.40036106 |
| 30 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.37058607 |
| 31 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.36476491 |
| 32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.33688463 |
| 33 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.32421875 |
| 34 | Base excision repair_Homo sapiens_hsa03410 | 1.28689988 |
| 35 | Purine metabolism_Homo sapiens_hsa00230 | 1.28583602 |
| 36 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.27433983 |
| 37 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.26659643 |
| 38 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.22864254 |
| 39 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.21610689 |
| 40 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.21351227 |
| 41 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.21069582 |
| 42 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.17257756 |
| 43 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.03018717 |
| 44 | Cell cycle_Homo sapiens_hsa04110 | 1.02956272 |
| 45 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.99981487 |
| 46 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.97739193 |
| 47 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.96926395 |
| 48 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.94359399 |
| 49 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.93754627 |
| 50 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.89027518 |
| 51 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.84712061 |
| 52 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.83550270 |
| 53 | Phototransduction_Homo sapiens_hsa04744 | 0.81723612 |
| 54 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.79737113 |
| 55 | Peroxisome_Homo sapiens_hsa04146 | 0.78740070 |
| 56 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.77061905 |
| 57 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.72031051 |
| 58 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.71882183 |
| 59 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.68640049 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.64202133 |
| 61 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.63909057 |
| 62 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.60459463 |
| 63 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.60159578 |
| 64 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.59326362 |
| 65 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.59039925 |
| 66 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.52263735 |
| 67 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.51825854 |
| 68 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.51337638 |
| 69 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.45654592 |
| 70 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.45070870 |
| 71 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.44573448 |
| 72 | Legionellosis_Homo sapiens_hsa05134 | 0.43150985 |
| 73 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.42598724 |
| 74 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.41225105 |
| 75 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.38713382 |
| 76 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.38239518 |
| 77 | Shigellosis_Homo sapiens_hsa05131 | 0.35389740 |
| 78 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.34997248 |
| 79 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.34352299 |
| 80 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.34301668 |
| 81 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.32744522 |
| 82 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.29513306 |
| 83 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.25941431 |
| 84 | Sulfur relay system_Homo sapiens_hsa04122 | 0.23129075 |
| 85 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.22814049 |
| 86 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.20842657 |
| 87 | Carbon metabolism_Homo sapiens_hsa01200 | 0.17707317 |
| 88 | Olfactory transduction_Homo sapiens_hsa04740 | 0.16917849 |
| 89 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.16039520 |
| 90 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.15523860 |
| 91 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.14545386 |
| 92 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.14064484 |
| 93 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.13235995 |
| 94 | Measles_Homo sapiens_hsa05162 | 0.13007849 |
| 95 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.12895458 |
| 96 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.11225783 |
| 97 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.10954431 |
| 98 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.10750969 |
| 99 | HTLV-I infection_Homo sapiens_hsa05166 | 0.09349612 |
| 100 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.07752205 |

