SBF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protein-tyrosine phosphatase family. However, the encoded protein does not appear to be a catalytically active phosphatase because it lacks several amino acids in the catalytic pocket. This protein contains a Guanine nucleotide exchange factor (GEF) domain which is necessary for its role in growth and differentiation. Mutations in this gene have been associated with Charcot-Marie-Tooth disease 4B3. Pseudogenes of this gene have been defined on chromosomes 1 and 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.55343152
2sodium ion export (GO:0071436)4.52019148
3negative regulation of erythrocyte differentiation (GO:0045647)4.49557203
4locomotory exploration behavior (GO:0035641)4.38824697
5regulation of ARF protein signal transduction (GO:0032012)4.05436320
6cytoskeletal anchoring at plasma membrane (GO:0007016)3.99883178
7regulation of ARF GTPase activity (GO:0032312)3.74397917
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.73278203
9layer formation in cerebral cortex (GO:0021819)3.71957620
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63632617
11negative regulation of cell killing (GO:0031342)3.63632617
12mannose metabolic process (GO:0006013)3.59393503
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.55032970
14cellular potassium ion homeostasis (GO:0030007)3.52137234
15protein localization to endosome (GO:0036010)3.47678234
16positive regulation of histone deacetylation (GO:0031065)3.33477595
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.32274696
18establishment of nucleus localization (GO:0040023)3.31393693
19activation of Rac GTPase activity (GO:0032863)3.21718881
20apoptotic process involved in morphogenesis (GO:0060561)3.20846853
21positive thymic T cell selection (GO:0045059)3.18058557
22regulation of gamma-delta T cell differentiation (GO:0045586)3.16838146
23positive regulation of Rap GTPase activity (GO:0032854)3.15585374
24signal complex assembly (GO:0007172)3.12548561
25negative thymic T cell selection (GO:0045060)3.12359201
26negative T cell selection (GO:0043383)3.10759508
27activation of protein kinase A activity (GO:0034199)3.09409418
28thymic T cell selection (GO:0045061)3.07196831
29regulation of early endosome to late endosome transport (GO:2000641)3.06659536
30negative regulation of cell size (GO:0045792)3.05534081
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.05322018
32glutamate secretion (GO:0014047)3.03020473
33peptidyl-lysine dimethylation (GO:0018027)3.02359427
34regulation of synapse structural plasticity (GO:0051823)3.01713246
35regulation of NFAT protein import into nucleus (GO:0051532)3.01259721
36positive regulation of gamma-delta T cell activation (GO:0046645)2.99797176
37semaphorin-plexin signaling pathway (GO:0071526)2.97648115
38regulation of Rap GTPase activity (GO:0032317)2.97078025
39negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96338431
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96104450
41positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.94815940
42positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.92497145
43stress fiber assembly (GO:0043149)2.86009513
44response to laminar fluid shear stress (GO:0034616)2.85343380
45cerebellar granule cell differentiation (GO:0021707)2.85340201
46cell-substrate junction assembly (GO:0007044)2.85322783
47nerve growth factor signaling pathway (GO:0038180)2.84345245
48negative regulation of myotube differentiation (GO:0010832)2.82369277
49cell communication by electrical coupling (GO:0010644)2.82042587
50cortical actin cytoskeleton organization (GO:0030866)2.82003444
51positive T cell selection (GO:0043368)2.81613515
52potassium ion import (GO:0010107)2.80605671
53neuromuscular process controlling balance (GO:0050885)2.79026889
54exploration behavior (GO:0035640)2.78910048
55regulation of glucose import in response to insulin stimulus (GO:2001273)2.77448722
56T cell selection (GO:0045058)2.77072337
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74395088
58activation of MAPKKK activity (GO:0000185)2.72386414
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.72378145
60planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71335365
61adherens junction assembly (GO:0034333)2.70323023
62regulation of gamma-delta T cell activation (GO:0046643)2.70271876
63positive regulation of synapse maturation (GO:0090129)2.69629064
64regulation of extracellular matrix disassembly (GO:0010715)2.68720877
65synaptic vesicle exocytosis (GO:0016079)2.68567947
66regulation of synaptic vesicle exocytosis (GO:2000300)2.66470242
67clathrin coat assembly (GO:0048268)2.65722056
68regulation of clathrin-mediated endocytosis (GO:2000369)2.65517437
69glycine transport (GO:0015816)2.64179532
70positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64143947
71regulation of glutamate receptor signaling pathway (GO:1900449)2.64122450
72vocalization behavior (GO:0071625)2.64059512
73dendrite morphogenesis (GO:0048813)2.63793762
74activation of JUN kinase activity (GO:0007257)2.63788847
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.63729939
76cerebellar Purkinje cell differentiation (GO:0021702)2.63038360
77regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62913656
78negative regulation of fatty acid transport (GO:2000192)2.62054328
79positive regulation of protein dephosphorylation (GO:0035307)2.61727391
80peptidyl-tyrosine autophosphorylation (GO:0038083)2.61162989
81cellular sodium ion homeostasis (GO:0006883)2.61146435
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.56261281
83response to muramyl dipeptide (GO:0032495)2.55989703
84retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.53958398
85positive regulation of fibroblast migration (GO:0010763)2.52709187
86dendritic spine morphogenesis (GO:0060997)2.52371102
87amino acid import (GO:0043090)2.52217792
88positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.52211940
89regulation of neuronal synaptic plasticity (GO:0048168)2.51519700
90peptidyl-threonine phosphorylation (GO:0018107)2.51117632
91plasma membrane repair (GO:0001778)2.48754402
92pre-miRNA processing (GO:0031054)2.48693297
93barbed-end actin filament capping (GO:0051016)2.48140040
94epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45807004
95regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45336643
96vesicle transport along microtubule (GO:0047496)2.44442857
97response to nerve growth factor (GO:1990089)2.44059034
98cellular response to nerve growth factor stimulus (GO:1990090)2.44059034
99positive regulation of receptor recycling (GO:0001921)2.43887405
100cell-substrate adherens junction assembly (GO:0007045)2.43368707
101focal adhesion assembly (GO:0048041)2.43368707
102protein retention in ER lumen (GO:0006621)2.42016199
103peptidyl-threonine modification (GO:0018210)2.41706091
104embryonic process involved in female pregnancy (GO:0060136)2.41561792
105prepulse inhibition (GO:0060134)2.40939031
106neurotransmitter secretion (GO:0007269)2.40712948
107cerebellar Purkinje cell layer development (GO:0021680)2.40705166
108antigen processing and presentation of endogenous antigen (GO:0019883)2.40223258
109cytoplasmic mRNA processing body assembly (GO:0033962)2.38774161
110maternal placenta development (GO:0001893)2.35431187
111positive regulation of myotube differentiation (GO:0010831)2.34363881
112modulation by symbiont of host cellular process (GO:0044068)2.33959156
113receptor catabolic process (GO:0032801)2.33028454
114intracellular estrogen receptor signaling pathway (GO:0030520)2.32928578
115cell-cell junction maintenance (GO:0045217)2.32540600
116membrane tubulation (GO:0097320)2.32157716
117negative regulation of organelle assembly (GO:1902116)2.31571168
118potassium ion homeostasis (GO:0055075)2.31566741
119NLS-bearing protein import into nucleus (GO:0006607)2.30888447
120long-term memory (GO:0007616)2.30138583
121insulin-like growth factor receptor signaling pathway (GO:0048009)2.29649460
122histone H3-K36 demethylation (GO:0070544)2.29396283
123regulation of dendritic spine morphogenesis (GO:0061001)2.29063736
124cellular response to epidermal growth factor stimulus (GO:0071364)2.29040957
125COPI coating of Golgi vesicle (GO:0048205)2.28259191
126Golgi transport vesicle coating (GO:0048200)2.28259191
127regulation of translational termination (GO:0006449)2.28082371
128histone H4 deacetylation (GO:0070933)2.27118132
129stress granule assembly (GO:0034063)2.26904858
130cortical cytoskeleton organization (GO:0030865)2.26756101
131regulation of long-term neuronal synaptic plasticity (GO:0048169)2.24827596
132cell migration in hindbrain (GO:0021535)2.23787235
133regulation of synaptic vesicle transport (GO:1902803)2.21575603
134modulation by virus of host process (GO:0019054)2.21527623
1353-UTR-mediated mRNA stabilization (GO:0070935)2.20796234
136negative regulation of nucleotide catabolic process (GO:0030812)2.20726149
137proline transport (GO:0015824)2.20654304
138regulation of cholesterol homeostasis (GO:2000188)2.19751889
139organelle transport along microtubule (GO:0072384)2.19495583
140negative regulation of Ras protein signal transduction (GO:0046580)2.18244399
141dopamine receptor signaling pathway (GO:0007212)2.17997038
142maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.16865157
143positive regulation of blood vessel endothelial cell migration (GO:0043536)2.16611551
144regulation of defense response to virus by virus (GO:0050690)2.16308377
145regulation of histone H3-K27 methylation (GO:0061085)2.16119459
146protein localization to synapse (GO:0035418)2.16080877
147positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.15923495
148protein targeting to plasma membrane (GO:0072661)2.15768594
149ionotropic glutamate receptor signaling pathway (GO:0035235)2.15737648
150positive regulation of Rac GTPase activity (GO:0032855)2.14577738
151glial cell proliferation (GO:0014009)2.13559618
152negative regulation of toll-like receptor signaling pathway (GO:0034122)2.13529920
153membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.12441748
154negative regulation of potassium ion transmembrane transport (GO:1901380)2.11272159
155L-amino acid import (GO:0043092)2.10463397
156synaptic vesicle endocytosis (GO:0048488)2.09085705

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.20368243
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14551873
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.01322166
4* KDM2B_26808549_Chip-Seq_DND41_Human2.91874537
5* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.88964671
6MYC_22102868_ChIP-Seq_BL_Human2.87496460
7KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.50343167
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44411641
9* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.43334854
10TCF7_22412390_ChIP-Seq_EML_Mouse2.41348692
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.34983569
12DROSHA_22980978_ChIP-Seq_HELA_Human2.34931271
13KDM2B_26808549_Chip-Seq_K562_Human2.24352355
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20710878
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20310177
16LXR_22292898_ChIP-Seq_THP-1_Human2.18930193
17KDM2B_26808549_Chip-Seq_JURKAT_Human2.13468219
18ZFP281_18757296_ChIP-ChIP_E14_Mouse2.12019311
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06500922
20EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.98112941
21ZFP281_27345836_Chip-Seq_ESCs_Mouse1.95685790
22* VDR_21846776_ChIP-Seq_THP-1_Human1.95345103
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94639136
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.90755870
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89013440
26GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.87755553
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.86434007
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.82996361
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82489601
30DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.77404887
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75044622
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.72385091
33EZH2_22144423_ChIP-Seq_EOC_Human1.72291813
34* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61586483
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61057861
36MAF_26560356_Chip-Seq_TH1_Human1.59757897
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58599567
38* UTX_26944678_Chip-Seq_JUKART_Human1.57597316
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57180490
40RUNX_20019798_ChIP-Seq_JUKART_Human1.54493942
41SPI1_23127762_ChIP-Seq_K562_Human1.48071977
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.47065525
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46356298
44RACK7_27058665_Chip-Seq_MCF-7_Human1.45370097
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43010635
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42962940
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41497496
48ZNF263_19887448_ChIP-Seq_K562_Human1.41097199
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39336260
50TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.37820369
51CREB1_26743006_Chip-Seq_LNCaP_Human1.37784946
52P68_20966046_ChIP-Seq_HELA_Human1.36695548
53SMC4_20622854_ChIP-Seq_HELA_Human1.34217466
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34115537
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33427659
56* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32909597
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31080873
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29505232
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29317219
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.27707248
61GATA1_19941826_ChIP-Seq_K562_Human1.27059645
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.26097861
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23541246
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19369237
65VDR_24763502_ChIP-Seq_THP-1_Human1.17444391
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17363123
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17198396
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15788296
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15524605
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.15438338
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13555713
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13325788
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12785559
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12504211
75REST_21632747_ChIP-Seq_MESCs_Mouse1.11449664
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10108596
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.09849590
78CLOCK_20551151_ChIP-Seq_293T_Human1.09288779
79MAF_26560356_Chip-Seq_TH2_Human1.09272954
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.09068058
81* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08256423
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08210013
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08068547
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07301043
85MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07191222
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06987166
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04665504
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04582570
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.04582004
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04508884
91CTCF_27219007_Chip-Seq_Bcells_Human1.03862439
92SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03192595
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02467563
94TP53_22127205_ChIP-Seq_IMR90_Human1.02064884
95NCOR1_26117541_ChIP-Seq_K562_Human1.01167435
96OCT4_19829295_ChIP-Seq_ESCs_Human1.01064144
97* TBX20_22328084_ChIP-Seq_HEART_Mouse1.00577243
98* TBX20_22080862_ChIP-Seq_HEART_Mouse1.00577243
99TET1_21490601_ChIP-Seq_MESCs_Mouse1.00306834
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00240906
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00108503
102EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00108503
103ERG_21242973_ChIP-ChIP_JURKAT_Human0.99475520
104* SA1_27219007_Chip-Seq_ERYTHROID_Human0.98559582
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98278071
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98107858
107GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97999174
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97500387
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95809585
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.95757544
111CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95446443
112* TP63_22573176_ChIP-Seq_HFKS_Human0.94927873
113ATF3_27146783_Chip-Seq_COLON_Human0.94434664
114FOXA2_19822575_ChIP-Seq_HepG2_Human0.94367659
115BCOR_27268052_Chip-Seq_Bcells_Human0.93826005
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93727576
117EZH2_27294783_Chip-Seq_ESCs_Mouse0.93603502
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93475698
119ETS1_21867929_ChIP-Seq_TH2_Mouse0.93127857
120KLF4_19829295_ChIP-Seq_ESCs_Human0.93024427
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92419689
122GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92094130
123BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91886269
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91362130
125TP53_23651856_ChIP-Seq_MEFs_Mouse0.90779357
126RNF2_27304074_Chip-Seq_ESCs_Mouse0.90761528
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90493126
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90204824
129SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89952658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.91055524
2MP0003705_abnormal_hypodermis_morpholog2.97846042
3MP0008961_abnormal_basal_metabolism2.81974767
4MP0005409_darkened_coat_color2.68423587
5MP0003635_abnormal_synaptic_transmissio2.62716122
6MP0003300_gastrointestinal_ulcer2.54314927
7MP0005451_abnormal_body_composition2.43507920
8MP0003303_peritoneal_inflammation2.38489757
9MP0000569_abnormal_digit_pigmentation2.32233599
10MP0008260_abnormal_autophagy2.32025057
11MP0003329_amyloid_beta_deposits2.26707078
12MP0010234_abnormal_vibrissa_follicle2.15565900
13MP0005058_abnormal_lysosome_morphology2.14475493
14MP0004858_abnormal_nervous_system2.14121561
15MP0005076_abnormal_cell_differentiation2.09434733
16MP0004270_analgesia2.07795069
17MP0003436_decreased_susceptibility_to2.03045502
18MP0004510_myositis2.00303646
19MP0002822_catalepsy1.99802933
20MP0008569_lethality_at_weaning1.98567027
21MP0000751_myopathy1.96558684
22MP0002063_abnormal_learning/memory/cond1.90673008
23MP0003453_abnormal_keratinocyte_physiol1.83000015
24MP0002064_seizures1.76375883
25MP0009780_abnormal_chondrocyte_physiolo1.73161640
26MP0002877_abnormal_melanocyte_morpholog1.71417701
27MP0004233_abnormal_muscle_weight1.68642150
28MP0009745_abnormal_behavioral_response1.65339475
29MP0004811_abnormal_neuron_physiology1.65012043
30MP0003091_abnormal_cell_migration1.64958288
31MP0002249_abnormal_larynx_morphology1.64051463
32MP0009278_abnormal_bone_marrow1.63889091
33MP0004130_abnormal_muscle_cell1.63361251
34MP0003045_fibrosis1.57614084
35MP0008438_abnormal_cutaneous_collagen1.56918489
36MP0005623_abnormal_meninges_morphology1.56332599
37MP0003172_abnormal_lysosome_physiology1.54526223
38MP0000747_muscle_weakness1.52196861
39MP0003279_aneurysm1.52167305
40MP0004381_abnormal_hair_follicle1.51874415
41MP0010352_gastrointestinal_tract_polyps1.51104720
42MP0000733_abnormal_muscle_development1.47499420
43MP0005423_abnormal_somatic_nervous1.45436165
44MP0002909_abnormal_adrenal_gland1.43122319
45MP0000604_amyloidosis1.42683155
46MP0001849_ear_inflammation1.40018468
47MP0009046_muscle_twitch1.38616129
48MP0003763_abnormal_thymus_physiology1.35992012
49MP0004185_abnormal_adipocyte_glucose1.32935665
50MP0004885_abnormal_endolymph1.32431877
51MP0004087_abnormal_muscle_fiber1.32274449
52MP0003283_abnormal_digestive_organ1.30488432
53MP0000003_abnormal_adipose_tissue1.27847527
54MP0003191_abnormal_cellular_cholesterol1.25263887
55MP0000920_abnormal_myelination1.23434107
56MP0000955_abnormal_spinal_cord1.23134758
57MP0009840_abnormal_foam_cell1.22944071
58MP0002089_abnormal_postnatal_growth/wei1.21594190
59MP0000678_abnormal_parathyroid_gland1.20311114
60MP0003633_abnormal_nervous_system1.18885111
61MP0000537_abnormal_urethra_morphology1.17403246
62MP0005375_adipose_tissue_phenotype1.17033362
63MP0001348_abnormal_lacrimal_gland1.16705297
64MP0003075_altered_response_to1.16453969
65MP0004947_skin_inflammation1.15471058
66MP0000858_altered_metastatic_potential1.15332619
67MP0003566_abnormal_cell_adhesion1.14567023
68MP0002572_abnormal_emotion/affect_behav1.13864038
69MP0002396_abnormal_hematopoietic_system1.09056027
70MP0000685_abnormal_immune_system1.07249912
71MP0002269_muscular_atrophy1.04924522
72MP0002272_abnormal_nervous_system1.04508176
73MP0008874_decreased_physiological_sensi1.04411070
74MP0003690_abnormal_glial_cell1.04290689
75MP0002998_abnormal_bone_remodeling1.03267334
76MP0008770_decreased_survivor_rate1.02717007
77MP0005666_abnormal_adipose_tissue1.01768138
78MP0000681_abnormal_thyroid_gland1.01159267
79MP0001486_abnormal_startle_reflex1.01085004
80MP0009333_abnormal_splenocyte_physiolog1.00611513
81MP0003634_abnormal_glial_cell0.99385736
82MP0002796_impaired_skin_barrier0.99312352
83MP0003787_abnormal_imprinting0.98435244
84MP0001873_stomach_inflammation0.98212755
85MP0005621_abnormal_cell_physiology0.98066543
86MP0000703_abnormal_thymus_morphology0.96724325
87MP0010630_abnormal_cardiac_muscle0.94593050
88MP0003123_paternal_imprinting0.94111175
89MP0004084_abnormal_cardiac_muscle0.93992113
90MP0003631_nervous_system_phenotype0.93637204
91MP0010307_abnormal_tumor_latency0.92373356
92MP0000759_abnormal_skeletal_muscle0.90792204
93MP0003880_abnormal_central_pattern0.90136624
94MP0002060_abnormal_skin_morphology0.89525668
95MP0001440_abnormal_grooming_behavior0.87388674
96MP0005670_abnormal_white_adipose0.86513786
97MP0003866_abnormal_defecation0.86432008
98MP0004808_abnormal_hematopoietic_stem0.86004152
99MP0001851_eye_inflammation0.85380506
100MP0002234_abnormal_pharynx_morphology0.85033721
101MP0000778_abnormal_nervous_system0.84230447
102MP0001968_abnormal_touch/_nociception0.83122136
103MP0001915_intracranial_hemorrhage0.82507155
104MP0005000_abnormal_immune_tolerance0.81898796
105MP0000579_abnormal_nail_morphology0.81651906
106MP0002066_abnormal_motor_capabilities/c0.81256788
107MP0002882_abnormal_neuron_morphology0.80374940
108MP0002152_abnormal_brain_morphology0.80195973
109MP0001958_emphysema0.79810853
110MP0005257_abnormal_intraocular_pressure0.78743590
111MP0002933_joint_inflammation0.77858499
112MP0000767_abnormal_smooth_muscle0.77654265
113MP0003115_abnormal_respiratory_system0.76526587
114MP0002734_abnormal_mechanical_nocicepti0.76418386
115MP0002398_abnormal_bone_marrow0.76312376
116MP0004924_abnormal_behavior0.75932561
117MP0005386_behavior/neurological_phenoty0.75932561
118MP0000013_abnormal_adipose_tissue0.75371185
119MP0005501_abnormal_skin_physiology0.74271981
120MP0009672_abnormal_birth_weight0.74091469
121MP0005025_abnormal_response_to0.73616501
122MP0002733_abnormal_thermal_nociception0.72721479
123MP0003632_abnormal_nervous_system0.72502725
124MP0001299_abnormal_eye_distance/0.71869821
125MP0000566_synostosis0.70547731
126MP0002420_abnormal_adaptive_immunity0.70357151
127MP0001970_abnormal_pain_threshold0.70125109
128MP0002184_abnormal_innervation0.68817824
129MP0010155_abnormal_intestine_physiology0.68710971
130MP0001533_abnormal_skeleton_physiology0.68706929
131MP0001819_abnormal_immune_cell0.68675450
132MP0002067_abnormal_sensory_capabilities0.68475247
133MP0004036_abnormal_muscle_relaxation0.68248884
134MP0002419_abnormal_innate_immunity0.67180499
135MP0002735_abnormal_chemical_nociception0.67023835
136MP0005023_abnormal_wound_healing0.66920344
137MP0005410_abnormal_fertilization0.66848211
138MP0001502_abnormal_circadian_rhythm0.66540143
139MP0005166_decreased_susceptibility_to0.66102663
140MP0005387_immune_system_phenotype0.65850471
141MP0001790_abnormal_immune_system0.65850471
142MP0003879_abnormal_hair_cell0.64931055
143MP0001800_abnormal_humoral_immune0.64410278
144MP0002106_abnormal_muscle_physiology0.63479883

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.11427556
2Hyperacusis (HP:0010780)3.77218784
3Abnormality of the lower motor neuron (HP:0002366)3.65385942
4Cerebral aneurysm (HP:0004944)3.22749834
5Insomnia (HP:0100785)3.12920862
6Myokymia (HP:0002411)3.12224022
7Broad face (HP:0000283)3.08373125
8Distal upper limb amyotrophy (HP:0007149)3.07868931
9Upper limb amyotrophy (HP:0009129)3.07868931
10Supranuclear gaze palsy (HP:0000605)3.02770308
11Dysmetric saccades (HP:0000641)2.84422420
12Pointed chin (HP:0000307)2.74648707
13Elfin facies (HP:0004428)2.67723832
14Macroorchidism (HP:0000053)2.64949754
15Urinary urgency (HP:0000012)2.63320816
16Difficulty running (HP:0009046)2.59892707
17Ankle clonus (HP:0011448)2.57746670
18Hand muscle atrophy (HP:0009130)2.51250306
19Hemiplegia (HP:0002301)2.46451168
20Overriding aorta (HP:0002623)2.46164451
21Lower limb amyotrophy (HP:0007210)2.45974616
22Renovascular hypertension (HP:0100817)2.45538867
23Shallow orbits (HP:0000586)2.45400354
24Heterotopia (HP:0002282)2.35995883
25Achilles tendon contracture (HP:0001771)2.35358088
26Eczematoid dermatitis (HP:0000976)2.32343139
27Thin bony cortex (HP:0002753)2.29689458
28Focal seizures (HP:0007359)2.28021573
29Frequent falls (HP:0002359)2.26005752
30Bowel diverticulosis (HP:0005222)2.24747918
31Disproportionate tall stature (HP:0001519)2.23671874
32Visual hallucinations (HP:0002367)2.22892768
33Action tremor (HP:0002345)2.22836843
34Cerebral inclusion bodies (HP:0100314)2.21420265
35Cellulitis (HP:0100658)2.21124793
36Postural instability (HP:0002172)2.19863568
37Spastic gait (HP:0002064)2.19039046
38Neoplasm of the heart (HP:0100544)2.17561384
39Mitral regurgitation (HP:0001653)2.15193878
40Abnormality of the Achilles tendon (HP:0005109)2.14419118
41Impaired vibration sensation in the lower limbs (HP:0002166)2.13323124
42Hyporeflexia of lower limbs (HP:0002600)2.13261200
43Urinary bladder sphincter dysfunction (HP:0002839)2.13223220
44Stridor (HP:0010307)2.12903307
45Abnormality of oral frenula (HP:0000190)2.12628756
46Termporal pattern (HP:0011008)2.11014208
47Insidious onset (HP:0003587)2.11014208
48Long palpebral fissure (HP:0000637)2.09385119
49Amyotrophic lateral sclerosis (HP:0007354)2.09207553
50Flat cornea (HP:0007720)2.07886588
51Broad metatarsal (HP:0001783)2.06730251
52Depression (HP:0000716)2.06601271
53Bundle branch block (HP:0011710)2.06077951
54Bladder diverticulum (HP:0000015)2.05431654
55Mitral valve prolapse (HP:0001634)2.02422486
56Colitis (HP:0002583)1.99351072
57Dilatation of the ascending aorta (HP:0005111)1.98631851
58Annular pancreas (HP:0001734)1.97011947
59Fragile skin (HP:0001030)1.96170079
60Ankyloglossia (HP:0010296)1.95885118
61Impaired social interactions (HP:0000735)1.95784620
62Abnormal social behavior (HP:0012433)1.95784620
63Dislocated radial head (HP:0003083)1.94795350
64Resting tremor (HP:0002322)1.94293430
65Dysmetria (HP:0001310)1.93112360
66Difficulty climbing stairs (HP:0003551)1.92365052
67Abnormality of the fingertips (HP:0001211)1.90790189
68Increased IgE level (HP:0003212)1.90433451
69Premature rupture of membranes (HP:0001788)1.89846607
70Intention tremor (HP:0002080)1.88734810
71Increased variability in muscle fiber diameter (HP:0003557)1.88427936
72Slow saccadic eye movements (HP:0000514)1.88136485
73Flat acetabular roof (HP:0003180)1.87891646
74Renal duplication (HP:0000075)1.87773967
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86734681
76Papilledema (HP:0001085)1.85777954
77Distal lower limb amyotrophy (HP:0008944)1.85033933
78Increased density of long bones (HP:0006392)1.84485729
79Rapidly progressive (HP:0003678)1.83731147
80Aortic aneurysm (HP:0004942)1.83498245
81Vertebral arch anomaly (HP:0008438)1.82989040
82Aneurysm (HP:0002617)1.82886121
83Bronchomalacia (HP:0002780)1.82449731
84Atrophic scars (HP:0001075)1.81088832
85Bowel incontinence (HP:0002607)1.80336828
86Impaired smooth pursuit (HP:0007772)1.79354950
87Abnormality of the radial head (HP:0003995)1.79310095
88Astrocytoma (HP:0009592)1.79205230
89Abnormality of the astrocytes (HP:0100707)1.79205230
90Vertebral compression fractures (HP:0002953)1.78975698
91Scapular winging (HP:0003691)1.76319533
92Mildly elevated creatine phosphokinase (HP:0008180)1.75537485
93Segmental peripheral demyelination/remyelination (HP:0003481)1.75004623
94Thin ribs (HP:0000883)1.74209115
95Abnormality of ocular smooth pursuit (HP:0000617)1.74099112
96Truncal ataxia (HP:0002078)1.74015128
97Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73936213
98Distal lower limb muscle weakness (HP:0009053)1.73800853
99Neuronal loss in central nervous system (HP:0002529)1.73729047
100Abnormality of the thoracic spine (HP:0100711)1.73521175
101Hemorrhage of the eye (HP:0011885)1.72547632
102Abnormality of the distal phalanx of the thumb (HP:0009617)1.72380521
103Centrally nucleated skeletal muscle fibers (HP:0003687)1.71296255
104Ulnar bowing (HP:0003031)1.71030500
105Striae distensae (HP:0001065)1.71027221
106Ventricular fibrillation (HP:0001663)1.70849597
107Obsessive-compulsive behavior (HP:0000722)1.70319506
108Germ cell neoplasia (HP:0100728)1.70064785
109Spinal canal stenosis (HP:0003416)1.70054028
110Papilloma (HP:0012740)1.69093887
111Verrucae (HP:0200043)1.69093887
112Genu recurvatum (HP:0002816)1.69033968
113Cervical subluxation (HP:0003308)1.68997351
114Narrow palate (HP:0000189)1.68975708
115Metaphyseal cupping (HP:0003021)1.68438214
116Hypercortisolism (HP:0001578)1.68178222
117Abnormality of skeletal muscle fiber size (HP:0012084)1.67064935
118Gastrointestinal inflammation (HP:0004386)1.66594879
119Polygenic inheritance (HP:0010982)1.66479719
120T lymphocytopenia (HP:0005403)1.66152993
121Emphysema (HP:0002097)1.66000443
122Peripheral hypomyelination (HP:0007182)1.65685232
123Neurofibrillary tangles (HP:0002185)1.65621804
124Premature skin wrinkling (HP:0100678)1.65310964
125Biconcave vertebral bodies (HP:0004586)1.64796962
126Hyperparathyroidism (HP:0000843)1.64729957
127Myopathic facies (HP:0002058)1.64002045
128Abnormal large intestine physiology (HP:0012700)1.63583216
129Long toe (HP:0010511)1.63310666
130Apathy (HP:0000741)1.62277227
131Poor eye contact (HP:0000817)1.61642361
132Lower limb muscle weakness (HP:0007340)1.61544094
133Protrusio acetabuli (HP:0003179)1.61420605
134Spinal cord lesions (HP:0100561)1.60879781
135Syringomyelia (HP:0003396)1.60879781
136Deep palmar crease (HP:0006191)1.60782561
137Exercise-induced myalgia (HP:0003738)1.60735600
138Short 4th metacarpal (HP:0010044)1.60716068
139Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.60716068
140Genetic anticipation (HP:0003743)1.60670566
141Dysdiadochokinesis (HP:0002075)1.60514861
142Nasal polyposis (HP:0100582)1.60131412
143Arnold-Chiari malformation (HP:0002308)1.60030961
144Turricephaly (HP:0000262)1.59957796
145Absent frontal sinuses (HP:0002688)1.58449390
146Increased connective tissue (HP:0009025)1.57917137
147Precocious puberty (HP:0000826)1.57881561
148Diplopia (HP:0000651)1.56210644
149Abnormality of binocular vision (HP:0011514)1.56210644
150Subacute progressive viral hepatitis (HP:0006572)1.56038271
151Interstitial pulmonary disease (HP:0006530)1.55381439
152Supernumerary nipples (HP:0002558)1.53694789
153Lower limb asymmetry (HP:0100559)1.53414945
154Wormian bones (HP:0002645)1.53200592
155Patellar dislocation (HP:0002999)1.53095097
156Foot dorsiflexor weakness (HP:0009027)1.52602438
157Easy fatigability (HP:0003388)1.52313979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.71517077
2EEF2K3.11029410
3SMG12.93528711
4PKN22.88892295
5MAP3K102.54126126
6MAP3K92.46441256
7PRKD32.37615528
8ICK2.16477746
9PAK62.13556125
10TYRO32.09550694
11RIPK11.99653664
12MAP4K11.99385267
13TTN1.97945734
14SIK21.95909539
15KSR21.83331554
16MAP3K71.70341170
17ALK1.61969369
18CAMKK11.59411229
19CDK121.59151413
20TAOK11.53701323
21IRAK31.51346105
22MAP3K131.48683099
23PRKCH1.48390758
24MAP2K31.43378431
25PTK61.39341363
26PDGFRA1.38985470
27NTRK21.37123769
28CAMK1G1.35175900
29RIPK41.34571071
30NTRK31.32729325
31EPHB11.25274417
32DAPK21.24860865
33SIK11.23525962
34STK381.23294298
35MARK21.22419825
36RET1.21266098
37FGFR41.17837915
38DMPK1.16058854
39BMX1.13142204
40FGFR21.08424950
41MARK11.08072567
42EPHA41.06310832
43MAP3K111.03470005
44NTRK11.01299188
45CAMK1D1.00972436
46MINK10.99945642
47PDK10.98467989
48FES0.96075464
49MAPK120.95561800
50MTOR0.95311200
51PDGFRB0.95172394
52ERN10.94797168
53GRK60.93919090
54JAK10.93083000
55SCYL20.93037650
56ARAF0.90567969
57MAP3K40.88192416
58TAOK20.85063416
59HCK0.83665336
60STK110.83485292
61LRRK20.83343424
62CDK50.82086615
63SGK30.80605090
64LMTK20.80103401
65IRAK20.79183035
66MAP3K30.77465722
67MAP3K60.76558692
68HIPK20.75989858
69PDPK10.75926723
70KSR10.75514352
71CDC42BPA0.75411723
72LATS20.75316093
73MAPK110.74606831
74ITK0.74099468
75PHKG20.73532912
76PHKG10.73532912
77FGFR30.73427362
78TNK20.72579503
79EPHA20.70783114
80PAK30.70652713
81WNK10.69106756
82MAP3K20.68680975
83PTK2B0.67480369
84RPS6KL10.67431565
85RPS6KC10.67431565
86DDR20.67420282
87PRKD20.66554072
88UHMK10.65837269
89MST1R0.65515589
90STK100.65193683
91PTK20.64838110
92PAK20.64606319
93BRD40.62099516
94PRKD10.61990817
95IRAK40.59140683
96CLK10.58997379
97FYN0.57388659
98FGFR10.55229458
99PRPF4B0.54812037
100ROCK20.54779416
101BRAF0.54035658
102JAK20.53839837
103CDK40.52890215
104DYRK1B0.52439314
105BLK0.51034916
106SIK30.50647538
107ZAP700.50387509
108CDK150.50222674
109JAK30.48247967
110CAMK10.48163180
111SGK2230.47972594
112SGK4940.47972594
113TBK10.47932612
114TESK10.47682950
115NEK20.47513381
116BTK0.46803610
117MAP3K10.45957175
118RPS6KA60.45877965
119PAK40.43729321
120CDK11A0.43350662
121CSK0.43159236
122CDK180.42863028
123MAPK70.42779510
124RPS6KA30.42012234
125TYK20.41364351
126MAP3K140.41320480
127NEK10.40933661
128MAP2K20.40365029
129MAPK100.40157405
130DAPK30.40142601
131MAPK80.39461231
132MOS0.39199269
133RPS6KA20.38975611
134CAMK40.38959183
135SRC0.38686162
136MAP3K80.36924666

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.13303059
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83739102
3Long-term potentiation_Homo sapiens_hsa047201.60250571
4Other glycan degradation_Homo sapiens_hsa005111.50782335
5mTOR signaling pathway_Homo sapiens_hsa041501.46965974
6Olfactory transduction_Homo sapiens_hsa047401.45193854
7Glioma_Homo sapiens_hsa052141.44856700
8Gastric acid secretion_Homo sapiens_hsa049711.44698932
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44114372
10Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43920798
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41862518
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41702256
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41122127
14Circadian entrainment_Homo sapiens_hsa047131.40972347
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40771854
16Type II diabetes mellitus_Homo sapiens_hsa049301.40491622
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39859992
18T cell receptor signaling pathway_Homo sapiens_hsa046601.36036886
19Salivary secretion_Homo sapiens_hsa049701.34485229
20Chronic myeloid leukemia_Homo sapiens_hsa052201.32296663
21B cell receptor signaling pathway_Homo sapiens_hsa046621.32238378
22VEGF signaling pathway_Homo sapiens_hsa043701.31327536
23Oxytocin signaling pathway_Homo sapiens_hsa049211.29070524
24Synaptic vesicle cycle_Homo sapiens_hsa047211.28381325
25Dorso-ventral axis formation_Homo sapiens_hsa043201.27712770
26Glutamatergic synapse_Homo sapiens_hsa047241.27015115
27Non-small cell lung cancer_Homo sapiens_hsa052231.26220734
28Estrogen signaling pathway_Homo sapiens_hsa049151.24384465
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.22767215
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22309947
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.19867900
32Cholinergic synapse_Homo sapiens_hsa047251.19653717
33Morphine addiction_Homo sapiens_hsa050321.19248835
34Prion diseases_Homo sapiens_hsa050201.18894844
35GABAergic synapse_Homo sapiens_hsa047271.17457192
36GnRH signaling pathway_Homo sapiens_hsa049121.15790787
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15499999
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15337906
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11789272
40Bladder cancer_Homo sapiens_hsa052191.10832813
41ErbB signaling pathway_Homo sapiens_hsa040121.10771702
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10722500
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09512802
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08102863
45Dopaminergic synapse_Homo sapiens_hsa047281.06073221
46Renal cell carcinoma_Homo sapiens_hsa052111.05010313
47Insulin secretion_Homo sapiens_hsa049111.03535268
48Endometrial cancer_Homo sapiens_hsa052131.03006573
49Dilated cardiomyopathy_Homo sapiens_hsa054141.02621436
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.02569970
51Renin secretion_Homo sapiens_hsa049241.01473467
52Gap junction_Homo sapiens_hsa045401.01033193
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00571523
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00397942
55Endocytosis_Homo sapiens_hsa041440.99961671
56Thyroid cancer_Homo sapiens_hsa052160.98455541
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98017730
58Amphetamine addiction_Homo sapiens_hsa050310.97054098
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96817972
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95859585
61Choline metabolism in cancer_Homo sapiens_hsa052310.92085543
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91116165
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90854584
64Acute myeloid leukemia_Homo sapiens_hsa052210.90720286
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90581801
66Insulin resistance_Homo sapiens_hsa049310.90463129
67Proteoglycans in cancer_Homo sapiens_hsa052050.89943533
68Axon guidance_Homo sapiens_hsa043600.89858023
69Platelet activation_Homo sapiens_hsa046110.89706733
70MAPK signaling pathway_Homo sapiens_hsa040100.88669537
71Primary immunodeficiency_Homo sapiens_hsa053400.88595625
72Pancreatic cancer_Homo sapiens_hsa052120.88421209
73Hepatitis B_Homo sapiens_hsa051610.87633824
74Insulin signaling pathway_Homo sapiens_hsa049100.87489178
75cAMP signaling pathway_Homo sapiens_hsa040240.87472449
76Chemokine signaling pathway_Homo sapiens_hsa040620.87397352
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87308818
78Colorectal cancer_Homo sapiens_hsa052100.86724858
79Lysine degradation_Homo sapiens_hsa003100.85241954
80Focal adhesion_Homo sapiens_hsa045100.84789737
81Osteoclast differentiation_Homo sapiens_hsa043800.83941091
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.82871738
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82628294
84Inositol phosphate metabolism_Homo sapiens_hsa005620.81175924
85Prostate cancer_Homo sapiens_hsa052150.81128739
86Glucagon signaling pathway_Homo sapiens_hsa049220.81016460
87Toxoplasmosis_Homo sapiens_hsa051450.80390667
88Rap1 signaling pathway_Homo sapiens_hsa040150.79995247
89Hepatitis C_Homo sapiens_hsa051600.79254124
90Cocaine addiction_Homo sapiens_hsa050300.78946724
91Long-term depression_Homo sapiens_hsa047300.78299311
92Small cell lung cancer_Homo sapiens_hsa052220.78240622
93Nicotine addiction_Homo sapiens_hsa050330.77743528
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77160069
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76818574
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76720417
97Amoebiasis_Homo sapiens_hsa051460.75923006
98Calcium signaling pathway_Homo sapiens_hsa040200.75768758
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75349131
100MicroRNAs in cancer_Homo sapiens_hsa052060.74357095
101TNF signaling pathway_Homo sapiens_hsa046680.74180407
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.72514267
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.72156110
104Bile secretion_Homo sapiens_hsa049760.71562313
105AMPK signaling pathway_Homo sapiens_hsa041520.71158604
106Apoptosis_Homo sapiens_hsa042100.70357554
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.69575627
108Viral myocarditis_Homo sapiens_hsa054160.68639202
109Leishmaniasis_Homo sapiens_hsa051400.68023335
110FoxO signaling pathway_Homo sapiens_hsa040680.65805036
111Prolactin signaling pathway_Homo sapiens_hsa049170.65782026
112Pancreatic secretion_Homo sapiens_hsa049720.65724920
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65649647
114Melanogenesis_Homo sapiens_hsa049160.65426688
115Viral carcinogenesis_Homo sapiens_hsa052030.64193391
116Adherens junction_Homo sapiens_hsa045200.64084959
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.63593078
118HTLV-I infection_Homo sapiens_hsa051660.63277397
119HIF-1 signaling pathway_Homo sapiens_hsa040660.62679807
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62513377
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.62405227
122Influenza A_Homo sapiens_hsa051640.61973947
123Notch signaling pathway_Homo sapiens_hsa043300.61248675
124Tuberculosis_Homo sapiens_hsa051520.58416381
125Thyroid hormone synthesis_Homo sapiens_hsa049180.58019026
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57276049
127Fructose and mannose metabolism_Homo sapiens_hsa000510.55698008

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